2876results about "Carboxylic compound separation/purification" patented technology

The invention relates to a pharmaceutically acceptable salt of a fused ring compound, and a crystal form and application thereof. Specifically, the present disclosure provides a pharmaceutically acceptable salt of 3-chloro-5-((5S, 5aS, 6S, 9R)-1-fluoro-12-((1-((4-(fluoromethylsubunit) piperidine-1-yl) methyl) cyclopropyl) methoxy)-5-methyl-5a, 6, 7, 8, 9, 10-hexahydro-5H-4-oxa-3, 10a, 11, 13, 14-pentaaza-6, 9-methylbridged naphtho [1, 8-ab] heptan-2-yl)-4-(trifluoromethyl) aniline, a crystal form, and a preparation method thereof, and a preparation method thereof. Corresponding salts have good stability and can be better used for clinical treatment. # imgabs0 #

The invention relates to a pharmaceutically acceptable salt of a fused ring compound, and a crystal form and application thereof. Specifically, the present disclosure provides a pharmaceutically acceptable salt of 3-chloro-5-((5S, 5aS, 6S, 9R)-1-fluoro-12-((1-((4-(fluoromethylsubunit) piperidine-1-yl) methyl) cyclopropyl) methoxy)-5-methyl-5a, 6, 7, 8, 9, 10-hexahydro-5H-4-oxa-3, 10a, 11, 13, 14-pentaaza-6, 9-methylbridged naphtho [1, 8-ab] heptan-2-yl)-4-(trifluoromethyl) aniline, a crystal form, and a preparation method thereof, and a preparation method thereof. Corresponding salts have good stability and can be better used for clinical treatment. # imgabs0 #

The invention relates to a pharmaceutically acceptable salt of a fused ring compound, and a crystal form and application thereof. Specifically, the present disclosure provides a pharmaceutically acceptable salt of 3-chloro-5-((5S, 5aS, 6S, 9R)-1-fluoro-12-((1-((4-(fluoromethylsubunit) piperidine-1-yl) methyl) cyclopropyl) methoxy)-5-methyl-5a, 6, 7, 8, 9, 10-hexahydro-5H-4-oxa-3, 10a, 11, 13, 14-pentaaza-6, 9-methylbridged naphtho [1, 8-ab] heptan-2-yl)-4-(trifluoromethyl) aniline, a crystal form, and a preparation method thereof, and a preparation method thereof. Corresponding salts have good stability and can be better used for clinical treatment. # imgabs0 #

The invention provides a baricitinib phthalate crystal form, and relates to the technical field of crystal form drug molecules. The crystal form is radiated by Cu-K alpha, and an X-ray diffraction pattern represented by 2 theta has characteristic peaks at 6.20 + / -0.2 degrees, 6.53 + / -0.2 degrees, 14.53 + / -0.2 degrees, 18.29 + / -0.2 degrees, 18.53 + / -0.2 degrees, 18.70 + / -0.2 degrees, 19.44 + / -0.2 degrees and 26.95 + / -0.2 degrees; the crystallographic measurement parameters are as follows: an orthorhombic system is adopted, and the space group is Pbcn; the cell parameters are as follows: # imgabs 0 # alpha = 90 degrees, beta = 90 degrees, gamma = 90 degrees, and the cell volume # imgabs 1 #. The invention also provides a related preparation method and application. The baricitinib phthalate crystal form disclosed by the invention is good in stability and relatively high in solubility and permeability.

The invention provides a production process of cobalt salt high-purity MO source electronic chemicals, relates to the technical field of chemical production processes, and realizes automation and intelligence of the production process by optimizing links such as pretreatment, dissolution and chemical reaction, intelligent crystallization separation, drying and vacuum sublimation of raw materials. The core technology comprises an improved long short-term memory (LSTM) algorithm used for adjusting dissolution conditions in real time, a Bayesian optimization algorithm used for optimizing the crystallization process, a self-adaptive dynamic programming algorithm used for optimizing energy consumption, and a support vector machine used for intelligent anomaly detection. The digital twin technology simulates and optimizes the production process, ensures the high purity and stability of the product, optimizes the reaction conditions, crystallization process, drying and vacuum sublimation steps in each process link, and ensures the high purity of the cobalt salt product.

A method for separating amoxicillin and phenylacetic acid from reaction solution in one-step enzymatic synthesis of amoxicillin is provided. The method employs immobilized penicillin acylase mutant to catalyze the one-step synthesis of amoxicillin from penicillin potassium, and develops a separation process for the resulting reaction mixture. The technical scheme mainly comprises: Firstly separating the immobilized penicillin acylase mutant from the reaction solution through filtration; subsequently isolating amoxicillin via crystallization; followed by separating and recovering phenylacetic acid through toluene extraction and back extraction. This separation method enables rapid and efficient isolation of amoxicillin with high production yield, achieving an average crystallization rate of 93.22%. Concurrently, it demonstrates effective separation and recovery of phenylacetic acid while allowing recyclable use of the toluene extractant.

The invention provides an adenosine dihydroxysuccinate eutectic crystal and a preparation method and application thereof.In the adenosine dihydroxysuccinate eutectic crystal, the molar ratio of a dihydroxysuccinic acid molecule to an adenosine molecule is 1: (1-4), on the premise that the structure of adenosine is not changed, dihydroxysuccinic acid and adenosine are combined, the water solubility of adenosine is improved, and therefore the adenosine dihydroxysuccinate eutectic crystal is obtained. According to the preparation method, the adenosine which is difficult to dissolve in water is prepared into the water-soluble adenosine dihydroxysuccinate eutectic crystal, so that the water solubility of the adenosine dihydroxysuccinate eutectic crystal can reach 4%, the effects of the adenosine dihydroxysuccinate and the adenosine monomer are not damaged, and the adenosine dihydroxysuccinate and the adenosine monomer have a better synergistic effect; compared with a monomer and a simple mixture, the composition has better effects in the aspects of antibiosis, antioxidation, anti-aging, hair care, hair loss prevention and the like, and has a good application prospect in skin and hair care products.

The invention belongs to the technical field of separation of products for synthesizing antibiotics by an enzymic method, and particularly relates to a method for separating and recycling an amoxicillin product synthesized by a one-step method based on catalysis of kluyveromyces citricacidophilus beta subunit G385 mutant penicillin acylase. An immobilized penicillin acylase mutant is used for catalyzing penicillin potassium to synthesize amoxicillin in one step, a set of method for separating amoxicillin and phenylacetic acid is developed for an obtained reaction mixture, and the technical scheme mainly comprises the following steps: firstly, separating the immobilized penicillin acylase mutant from a reaction solution through filtration; then, amoxicillin is separated out through crystallization; and then crystallizing, separating and recovering phenylacetic acid through toluene extraction, back extraction and the like. According to the separation method, the amoxicillin can be rapidly and efficiently separated, the yield of the amoxicillin is relatively high, and the average crystallization rate reaches 93.22%; meanwhile, the separation and recovery effects of phenylacetic acid are good; and the extraction agent toluene can be recycled.

Various aspects of this disclosure relate to methods to lower the activation energy of the cannabinoid decarboxylation reaction by performing the decarboxylation reaction in the gas phase.

A system for preparing acrylic acid by utilizing carbon dioxide through electro-biological coupling is characterized by comprising an electro-catalysis methanol production unit, a biological fermentation 3-hydracrylic acid production unit, a 3-hydracrylic acid purification unit and an acrylic acid production unit which are connected in sequence, the electro-catalysis methanol production unit is used for carrying out electro-catalysis on hydrogen produced by water through solar electrolysis and carbon dioxide directly captured by air under the action of a ZnO-ZrO2 catalyst to obtain methanol; the unit for producing the 3-hydracrylic acid through biological fermentation takes the methanol obtained by the electrocatalysis unit as a substrate to carry out biological fermentation, and a fermentation product is subjected to gas-liquid separation to obtain fermentation liquor containing the 3-hydracrylic acid; the 3-hydracrylic acid purification unit is used for carrying out solid-liquid separation on the obtained fermentation liquor of the 3-hydracrylic acid and extracting to obtain the 3-hydracrylic acid; the acrylic acid production unit is used for carrying out dehydration reaction on the purified 3-hydracrylic acid to obtain acrylic acid; carbon dioxide is fixed through an electrocatalysis and biological fermentation coupling technology, and the problem that existing fossil-based raw materials are high in dependency degree is solved.

The invention provides a method for producing long-chain dicarboxylic acid and a long-chain dicarboxylic acid product. The method comprises the following steps: inoculating a seed solution of a fermentation strain into a fermentation tank, wherein a fermentation substrate comprises any one or more of fatty acid and derivatives thereof, and alkane; according to the method, green raw materials such as fatty acid and derivatives thereof, plant-based alkane and the like are adopted as substrates to partially or completely replace fossil energy such as petroleum alkane and the like, the product is green long-chain binary acid, and the bio-based content can be regulated and controlled. And the fermentation method provided by the invention can still maintain relatively high yield and conversion rate.

The invention provides a method for recovering waste etching liquid containing phosphoric acid, acetic acid and nitric acid, which comprises the following steps: carrying out reduced pressure distillation on the waste etching liquid under a reduced pressure condition, distilling and condensing light components of nitric acid and acetic acid to obtain mixed acid liquor of acetic acid and nitric acid, and detecting the content of nitric acid, acetic acid and water in the mixed acid liquor; adding sodium hydroxide or potassium hydroxide and the like into mixed acid liquor of acetic acid and nitric acid, so that all nitric acid in the mixed acid liquor generates nitrate; and adding acetic anhydride into the acetic acid-containing mixed solution, fully reacting, filtering the separated salt, adding an extracting agent into the filtrate, and collecting the high-purity acetic acid. According to the method, phosphoric acid, acetic acid and nitrate in the waste etching liquid are recycled, the recycled acetic acid is high in purity, high in recycling rate and high in operability, large-scale production can be met, resource recycling is achieved to the maximum extent, direct emission of non-phosphorus resources of the waste etching liquid is avoided, and resource waste and environmental pollution are avoided.

The invention provides a hydrated compound and a preparation method thereof, and relates to the technical field of compound preparation. The hydrated compound is rupatinifen fumarate monohydrate and has a crystal structure. The preparation method of the hydrated compound comprises the following steps: adding rupatinifen fumarate into a reaction solvent at least containing a first organic solvent, heating, stirring and refluxing until the rupatinifen fumarate is completely dissolved, the concentration of the rupatinifen fumarate in a reaction system is not lower than 70% of the concentration of a saturated solution of the rupatinifen fumarate in the reaction system, and carrying out solid-liquid separation to obtain the hydrated compound. And continuously refluxing for 1 min to 24 h, cooling to the temperature not exceeding 8 DEG C, crystallizing, collecting crystals, washing and drying to obtain the product.

The present invention discloses a polyketide compound and its application in the preparation of a drug for treating pulmonary fibrosis. The polyketide compound or its pharmaceutically acceptable salt, ester, or solvate provided by the present invention can effectively inhibit fibrosis of tissues and organs in the respiratory system; the marine natural product has good application prospects in drugs for treating fibrosis of respiratory organs, especially drugs for treating pulmonary fibrosis, providing new means and new ideas for treating fibrotic diseases.

The invention discloses a preparation method and application of a composite catalyst for preparing carbon dioxide-based polycarbonate, and belongs to the technical field of catalysts, and the composite catalyst is a binary catalytic system obtained by combining double metal cyanide and activated zinc carboxylate according to a certain proportion. After zinc carboxylate is activated by water or ethanol, the catalytic activity is greatly improved. The activity of the composite catalyst for catalyzing ring-opening copolymerization of carbon dioxide and epoxypropane is greater than 1500g polymer / g catalyst, the number-average molecular weight of the obtained product polycarbonate is greater than 150,000, and the selectivity is greater than 98%. Compared with single use of double metal cyanide or zinc carboxylate, the composite catalyst has remarkable advantages, and is simple in synthesis process, relatively low in cost and very suitable for industrial production of carbon dioxide-based polycarbonate.

The invention discloses a method for preparing high-purity nickel acetate from crude nickel carbonate in the technical field of nickel compound purification, which comprises the following steps: mixing the crude nickel carbonate with deionized water to obtain a suspension, and adding glacial acetic acid to react to obtain a nickel acetate solution; then a specially-made hierarchical-pore titanium silicalite molecular sieve loaded bimetallic nanocluster material is added for purification treatment, the material is obtained through precise preparation, the method comprises the steps of carrier modification, bimetallic loading, hydrophobic modification, activation balance and the like, and the material has excellent impurity adsorption capacity and chemical stability; carrying out concentration crystallization and solid-liquid separation on the purified solution to obtain wet nickel acetate crystals; the mother liquor is subjected to adsorption treatment again, crystals in the mother liquor are recycled, and finally all the crystals are combined and dried to obtain a high-purity nickel acetate product. The process is simple and efficient, the purity of the prepared nickel acetate exceeds 98.5%, the content of each impurity is superior to the industrial standard, and the mother liquor can be recycled, is environment-friendly and is suitable for industrial production.

The invention belongs to the technical field of medicines, and particularly relates to a pirfenidone eutectic crystal and a preparation method, a pharmaceutical composition and application thereof. The pirfenidone eutectic provided by the invention is prepared from pirfenidone and a eutectic ligand, and the eutectic ligand is selected from one of pimelic acid, cinnamic acid and saccharin. The pirfenidone eutectic crystal provided by the invention not only can improve the acute pancreatitis relieving effect of pirfenidone, but also can improve the safety of pirfenidone.

The present application belongs to the field of medicines, and particularly relates to a pharmaceutical cocrystal of finerenone and maleic acid, and a preparation method therefor. The pharmaceutical cocrystal of finerenone and maleic acid prepared in the present application has the advantages of high purity, suitable solubility, good stability, etc. and is suitable for new drug development and industrial production. The method for preparing the pharmaceutical cocrystal of finerenone and maleic acid provided in the present application has the advantages of simple process route and low cost, and is suitable for industrial production.

The present application discloses a method for preparing calcium gluconate, which comprises enzymatic hydrolysis of starch into glucose, and then oxidation reaction of glucose and calcium carbonate under the action of polyether defoaming agent, catalase and glucose oxidase. The liquid surface in the oxidation tank is in contact with the gas phase in the tank and the replacement is fast, which accelerates the oxidation of glucose and improves the oxidation reaction process. The reaction process can be made close to theoretical expectations in a shorter time, and the generation of side reaction products is reduced, thereby improving the product yield and purity.

The invention provides a method for treating wastewater in the production process of o-chlorobenzonitrile by an ammonia oxidation process, comprising: high-temperature reaction gas from a reactor enters two mixed capture devices in sequence, a circulating spray pump of the mixed capture device is turned on, a medium in the reaction gas is captured and absorbed to the bottom of the collector by two mixed capture modes of dry condensation and spray flushing of a collector condensation chamber and a capture absorption chamber partition, and is sent to a downstream separation circulation tank through a discharge pipe at the bottom of the collector for natural sedimentation; wastewater settled in the separation circulation tank is passed into an oxidation reactor, an active oxidant is arranged in the oxidation reactor, the oxidant is generated immediately with the passing of the wastewater, and o-chlorobenzaldehyde in the wastewater is oxidized to o-chlorobenzoic acid; the wastewater solution after the reaction in the oxidation reactor enters a sedimentation kettle for sedimentation, the upper clear liquid after sedimentation is circulated into the two mixed capture devices for capture and absorption, and the lower precipitate enters a dryer for drying to obtain an o-chlorobenzoic acid product.

The invention belongs to the technical field of lithium ion batteries, and particularly discloses a nanoscale Li2C2O4 positive electrode lithium supplement agent and a preparation method and application thereof. The preparation method comprises the following steps: mixing Li2C2O4 with a solvent, and uniformly stirring to obtain a mixed solution A; adding a conductive skeleton into the mixed solution A, and uniformly stirring to obtain a mixed solution B; adding a dispersing agent into the mixed solution B, and uniformly stirring to obtain a mixed solution C; and transferring the mixed solution C into a hydrothermal reaction kettle, heating to a certain temperature, preserving heat for 2 hours, cooling to room temperature, carrying out suction filtration, and drying to obtain the nanoscale Li2C2O4 positive electrode lithium supplement agent. The invention discloses a nanoscale Li2C2O4 positive electrode lithium supplement agent and a preparation method and application thereof.The nanoscale Li2C2O4 positive electrode lithium supplement agent is low in decomposition voltage platform, high in capacity release rate, good in air stability and capable of providing sufficient reaction sites in the electrochemical reaction process and shortening the ion transmission path, and the method is simple in technological process, low in cost and suitable for industrial production. And the method has remarkable industrial benefits.

The invention discloses a method for recovering valuable metals in a retired ternary lithium battery based on cascade separation of a deep eutectic solvent and oxalic acid. The method comprises the following steps: 1) stirring and leaching the deep eutectic solvent and black powder at 110-130 DEG C for 3-4 hours according to a liquid-solid ratio of (5-50): 1 (ml: g) to obtain a leaching solution; (2) measuring the contents of lithium, cobalt, nickel and manganese in the leachate according to ICP (Inductively Coupled Plasma), adding oxalic acid exceeding the required amount according to the contents of lithium, cobalt, nickel and manganese, stirring, standing, and centrifuging to obtain a precipitate mixture of nickel oxalate precipitate, cobalt oxalate precipitate and manganese oxalate precipitate and lithium filtrate; and (3) repeating the steps (1)-(2) for at least three times by taking the lithium filtrate obtained at each time as the eutectic solvent, performing rotary evaporation on the obtained final lithium filtrate, adding sodium carbonate, and centrifuging to obtain lithium carbonate precipitate. The purity of the ternary lithium precursor prepared from cobalt, nickel and manganese obtained through the method can reach 99% or above, the purity of obtained lithium carbonate reaches 95% or above, and closed-loop recycling is achieved.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a crystal form of triphenylacetic acid rafenasin and a preparation method thereof. The crystal form has good chemical stability and crystal form purity, is easy for large-scale preparation, can be better suitable for preparation of pharmaceutical preparations and large-scale production, and has a wide application prospect.

The invention discloses a comprehensive utilization method of high-salinity wastewater produced by hydrometallurgical treatment of bastnaesite, which comprises the following steps: A, mixing alkaline wastewater and acidic wastewater, neutralizing and clarifying to obtain calcium fluoride and sodium chloride wastewater; b, mixing the sodium chloride wastewater with the precipitation wastewater, adding lime water in an aeration manner to adjust the pH value, hydrolyzing heavy metal ions in the wastewater, and performing solid-liquid separation to obtain filter residues and filtrate which is sodium chloride high-salinity wastewater; and C, adding oxalic acid into the sodium chloride high-salinity wastewater, stirring, standing, carrying out solid-liquid separation, pressurizing, concentrating, recovering hydrochloric acid, and crystallizing to obtain a crystal substance, namely a sodium chloride product. According to the method, fluorine in the wastewater is removed firstly, then the wastewater is recovered into wastewater containing sodium chloride, oxalate is dissolved into the high-salinity wastewater to separate out sodium oxalate and recover hydrochloric acid, so that the content of sodium chloride in the system is greatly reduced, and the recovery efficiency of sodium ions in the wastewater is improved.

The invention discloses a preparation method of superfine calcium citrate suitable for liquid calcium, which comprises the following steps: S1, taking citric acid, citrate and calcium carbonate to react in water to obtain calcium citrate; the reaction temperature ranges from 80 DEG C to 90 DEG C, and the reaction time ranges from 10 min to 20 min; s2, performing vacuum freeze drying and primary crushing on the calcium citrate to obtain coarse powder; s3, absolute ethyl alcohol is added into the coarse powder and mixed evenly, low-temperature superfine grinding is carried out, the adding amount of the absolute ethyl alcohol is 8%-10% of the mass of the coarse powder, and the low-temperature superfine grinding temperature is 0-5 DEG C. On the basis of a normal calcium citrate preparation method, the calcium citrate is crushed and dispersed at a low temperature by using vacuum freeze drying, stabilizer adding and ice crystallization superfine grinding technologies, so that the structural stability of the calcium citrate is improved, and the problems of layering, thickening, solidification and the like are avoided when the calcium citrate is applied to liquid calcium.

The invention belongs to the technical field of waste PET (Polyethylene Terephthalate) recovery, and particularly relates to a continuous production system and process for efficiently recovering and refining PTA (Purified Terephthalic Acid) from waste PET and application. According to the continuous production system and process for efficiently recovering and refining the PTA from the waste PET, through mutual cooperation of the enzymolysis unit, the first solid-liquid separation unit, the filter cake dissolving and decolorizing unit, the electrolysis unit, the second solid-liquid separation unit and the recrystallization unit, continuous production of'obtaining the refined PTA by taking the waste PET as a raw material 'is realized; besides, by adjusting the runner structure in the electrolysis assembly of the electrolysis unit, the situation of electrolysis interruption caused by the fact that TA generated by electrolysis is prone to being deposited on the surface of the anode plate is avoided, guarantee is provided for continuous proceeding of the whole degradation and recovery process, and the system and the process have important significance on efficient degradation and recovery of waste PET.

Provided is a method for producing azelaic acid particles, the method being characterized by comprising: a solution preparation step for preparing an azelaic acid solution in which azelaic acid is dissolved in a good solvent; a crystallization step for mixing the azelaic acid solution prepared in the solution preparation step with purified water serving as a poor solvent to precipitate crystals; and a drying step for drying the product obtained in the crystallization step in a stand-still state.

The invention relates to a preparation method of magnesium threonate, which comprises the following steps: taking magnesium hydroxide, vitamin C and hydrogen peroxide which are cheap and easy to obtain as raw materials, reacting in ethanol to obtain a target product, and recrystallizing through an ethanol and water system to obtain pure magnesium threonate.

The invention provides a method for extracting and refining long-chain dicarboxylic acid and a product, and the method comprises the following steps: (1) carrying out heating treatment on fermentation liquor of long-chain dicarboxylic acid to reduce the content of insoluble substances in the fermentation liquor so as to obtain mixed feed liquor in which the dry weight ratio of the insoluble substances is less than 4wt%; (2) filtering the mixed material liquid to obtain filtrate, carrying out acidification crystallization treatment and solid-liquid separation treatment on the filtrate through or without decoloration treatment to obtain a first solid; and (3) refining the first solid. The extraction and refining method provided by the invention can improve the purity and quality of the long-chain dicarboxylic acid product, and the product has large particle size, is simple and easy to operate, and is beneficial to large-scale industrial production.

The invention relates to gluconic acid pentazocine benzoate as shown in a formula (I), and a preparation method, a pharmaceutical preparation and medical application thereof. The invention provides application of the compound in preparation of medicines for treating moderate and severe acute and chronic pains, and the compound has the effects of high efficacy and low side effect. # imgabs0 #