2107results about "Carboxylic compound separation/purification" patented technology

A method for separating amoxicillin and phenylacetic acid from reaction solution in one-step enzymatic synthesis of amoxicillin is provided. The method employs immobilized penicillin acylase mutant to catalyze the one-step synthesis of amoxicillin from penicillin potassium, and develops a separation process for the resulting reaction mixture. The technical scheme mainly comprises: Firstly separating the immobilized penicillin acylase mutant from the reaction solution through filtration; subsequently isolating amoxicillin via crystallization; followed by separating and recovering phenylacetic acid through toluene extraction and back extraction. This separation method enables rapid and efficient isolation of amoxicillin with high production yield, achieving an average crystallization rate of 93.22%. Concurrently, it demonstrates effective separation and recovery of phenylacetic acid while allowing recyclable use of the toluene extractant.

The invention belongs to the technical field of separation of products for synthesizing antibiotics by an enzymic method, and particularly relates to a method for separating and recycling an amoxicillin product synthesized by a one-step method based on catalysis of kluyveromyces citricacidophilus beta subunit G385 mutant penicillin acylase. An immobilized penicillin acylase mutant is used for catalyzing penicillin potassium to synthesize amoxicillin in one step, a set of method for separating amoxicillin and phenylacetic acid is developed for an obtained reaction mixture, and the technical scheme mainly comprises the following steps: firstly, separating the immobilized penicillin acylase mutant from a reaction solution through filtration; then, amoxicillin is separated out through crystallization; and then crystallizing, separating and recovering phenylacetic acid through toluene extraction, back extraction and the like. According to the separation method, the amoxicillin can be rapidly and efficiently separated, the yield of the amoxicillin is relatively high, and the average crystallization rate reaches 93.22%; meanwhile, the separation and recovery effects of phenylacetic acid are good; and the extraction agent toluene can be recycled.

Various aspects of this disclosure relate to methods to lower the activation energy of the cannabinoid decarboxylation reaction by performing the decarboxylation reaction in the gas phase.

The invention provides a method for producing long-chain dicarboxylic acid and a long-chain dicarboxylic acid product. The method comprises the following steps: inoculating a seed solution of a fermentation strain into a fermentation tank, wherein a fermentation substrate comprises any one or more of fatty acid and derivatives thereof, and alkane; according to the method, green raw materials such as fatty acid and derivatives thereof, plant-based alkane and the like are adopted as substrates to partially or completely replace fossil energy such as petroleum alkane and the like, the product is green long-chain binary acid, and the bio-based content can be regulated and controlled. And the fermentation method provided by the invention can still maintain relatively high yield and conversion rate.

The invention discloses a preparation method and application of a composite catalyst for preparing carbon dioxide-based polycarbonate, and belongs to the technical field of catalysts, and the composite catalyst is a binary catalytic system obtained by combining double metal cyanide and activated zinc carboxylate according to a certain proportion. After zinc carboxylate is activated by water or ethanol, the catalytic activity is greatly improved. The activity of the composite catalyst for catalyzing ring-opening copolymerization of carbon dioxide and epoxypropane is greater than 1500g polymer / g catalyst, the number-average molecular weight of the obtained product polycarbonate is greater than 150,000, and the selectivity is greater than 98%. Compared with single use of double metal cyanide or zinc carboxylate, the composite catalyst has remarkable advantages, and is simple in synthesis process, relatively low in cost and very suitable for industrial production of carbon dioxide-based polycarbonate.

The invention discloses a method for preparing high-purity nickel acetate from crude nickel carbonate in the technical field of nickel compound purification, which comprises the following steps: mixing the crude nickel carbonate with deionized water to obtain a suspension, and adding glacial acetic acid to react to obtain a nickel acetate solution; then a specially-made hierarchical-pore titanium silicalite molecular sieve loaded bimetallic nanocluster material is added for purification treatment, the material is obtained through precise preparation, the method comprises the steps of carrier modification, bimetallic loading, hydrophobic modification, activation balance and the like, and the material has excellent impurity adsorption capacity and chemical stability; carrying out concentration crystallization and solid-liquid separation on the purified solution to obtain wet nickel acetate crystals; the mother liquor is subjected to adsorption treatment again, crystals in the mother liquor are recycled, and finally all the crystals are combined and dried to obtain a high-purity nickel acetate product. The process is simple and efficient, the purity of the prepared nickel acetate exceeds 98.5%, the content of each impurity is superior to the industrial standard, and the mother liquor can be recycled, is environment-friendly and is suitable for industrial production.

The present application belongs to the field of medicines, and particularly relates to a pharmaceutical cocrystal of finerenone and maleic acid, and a preparation method therefor. The pharmaceutical cocrystal of finerenone and maleic acid prepared in the present application has the advantages of high purity, suitable solubility, good stability, etc. and is suitable for new drug development and industrial production. The method for preparing the pharmaceutical cocrystal of finerenone and maleic acid provided in the present application has the advantages of simple process route and low cost, and is suitable for industrial production.

The invention belongs to the technical field of lithium ion batteries, and particularly discloses a nanoscale Li2C2O4 positive electrode lithium supplement agent and a preparation method and application thereof. The preparation method comprises the following steps: mixing Li2C2O4 with a solvent, and uniformly stirring to obtain a mixed solution A; adding a conductive skeleton into the mixed solution A, and uniformly stirring to obtain a mixed solution B; adding a dispersing agent into the mixed solution B, and uniformly stirring to obtain a mixed solution C; and transferring the mixed solution C into a hydrothermal reaction kettle, heating to a certain temperature, preserving heat for 2 hours, cooling to room temperature, carrying out suction filtration, and drying to obtain the nanoscale Li2C2O4 positive electrode lithium supplement agent. The invention discloses a nanoscale Li2C2O4 positive electrode lithium supplement agent and a preparation method and application thereof.The nanoscale Li2C2O4 positive electrode lithium supplement agent is low in decomposition voltage platform, high in capacity release rate, good in air stability and capable of providing sufficient reaction sites in the electrochemical reaction process and shortening the ion transmission path, and the method is simple in technological process, low in cost and suitable for industrial production. And the method has remarkable industrial benefits.

The invention discloses a preparation method of superfine calcium citrate suitable for liquid calcium, which comprises the following steps: S1, taking citric acid, citrate and calcium carbonate to react in water to obtain calcium citrate; the reaction temperature ranges from 80 DEG C to 90 DEG C, and the reaction time ranges from 10 min to 20 min; s2, performing vacuum freeze drying and primary crushing on the calcium citrate to obtain coarse powder; s3, absolute ethyl alcohol is added into the coarse powder and mixed evenly, low-temperature superfine grinding is carried out, the adding amount of the absolute ethyl alcohol is 8%-10% of the mass of the coarse powder, and the low-temperature superfine grinding temperature is 0-5 DEG C. On the basis of a normal calcium citrate preparation method, the calcium citrate is crushed and dispersed at a low temperature by using vacuum freeze drying, stabilizer adding and ice crystallization superfine grinding technologies, so that the structural stability of the calcium citrate is improved, and the problems of layering, thickening, solidification and the like are avoided when the calcium citrate is applied to liquid calcium.

The invention relates to a preparation method of magnesium threonate, which comprises the following steps: taking magnesium hydroxide, vitamin C and hydrogen peroxide which are cheap and easy to obtain as raw materials, reacting in ethanol to obtain a target product, and recrystallizing through an ethanol and water system to obtain pure magnesium threonate.

The invention relates to gluconic acid pentazocine benzoate as shown in a formula (I), and a preparation method, a pharmaceutical preparation and medical application thereof. The invention provides application of the compound in preparation of medicines for treating moderate and severe acute and chronic pains, and the compound has the effects of high efficacy and low side effect. # imgabs0 #

Extraction media for removal, concentration, and recovery of PEAS from contaminated materials in fluorous biphasic and / or multiphasic systems and related methods. The systems may include a fluorous functionalized solid support and a fluorous fractionation reactor permitting PFAS separation for targeted recovery. Extraction mediums comprise a polyelectrolyte with carbon dioxide / supercritical carbon dioxide (CO2 / SCCO2) with additional possible reagent modifiers that permit miscibility switches and compatibility with NSF / ANSI certifications. The extraction medium may include modifiers to enhance targeted recovery, such as F -solvents and / or organic carrier solvents. The disclosed systems and methods permit advantages such as 1 ) reduced sensitivity to PFAS-impacted phase co-contam inants such as competing anionic species and / or organic contaminants, 2) simple contact reactor retrofits, 3) enhanced removal of ultra- and / or short chain PFAS, 4) enhanced uniformity of matrix chemistry for downstream waste / wastewater management processes, and 5) the ability to recover valuable PFAS from waste / wastewater for processes that are dependent on their chemistry.

The invention relates to the technical field of polymer dye synthesis, in particular to a polymer coloring agent based on a binary acid chromophoric monomer, a color master batch, a fiber and a preparation method of the polymer coloring agent. The structural formula of the diacid chromophoric monomer is as follows: # imgabs0. The chromophoric monomer has extremely high thermal stability, and can maintain the chemical structural integrity and chromophoric performance in a high-temperature environment (250 DEG C). The heat-resistant characteristic is mainly derived from a highly stable aromatic skeleton formed by a parent nucleus through an expanded conjugated system and a rigid plane structure, and heat vibration energy is effectively dispersed; in addition, a thermal stable group (an all-carbon skeleton) is introduced through side chain modification to form a steric hindrance effect, and molecular movement at high temperature is inhibited. Due to the unique heat resistance of the monomer, the monomer can be completely matched with a high-temperature processing window (240-300 DEG C) of a polyester melt polymerization process, and a polymer-dye composite system with a stable structure is constructed through covalent bonding in ester exchange and polycondensation processes.

The invention provides a method for separating EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) through supercritical fluid chromatography, and relates to the technical field of separation and purification. The invention provides a method for separating EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) by supercritical fluid chromatography, which comprises the following steps: by taking supercritical carbon dioxide and an organic reagent as mobile phases, and by utilizing the specific mobile phase property of supercritical CO2 after being mixed with the organic reagent (saturated aliphatic hydrocarbon) and matching with a normal-phase chromatographic column, separating the EPA from the DHA by supercritical fluid chromatography. A specific stationary phase (one or more of a silica gel surface bonded propylurea stationary phase, a silica gel surface bonded phenyl stationary phase and a silica gel surface bonded imidazolyl stationary phase) is adopted, effective separation and preparation of the EPA and the DHA in the fish oil can be achieved, the EPA and the DHA in the fish oil can be effectively separated within 50 min, the separation speed is high, the separation effect is good, and the method is suitable for industrial production. The purity of the obtained EPA and DHA is 98% or above, the purity of the EPA and the DHA is high, and the EPA and the DHA have good application prospects in the fields of medicine production and food and health care products.

The present invention addresses the problem of how to effectively and efficiently extract, separate, and recover high-concentration PFAS contained in water regardless of the type of PFAS. An organic fluorine compound is converted to a chemical species having a negative charge on the basis of ionization by acid dissociation of the organic fluorine compound, molecularization of protonation-type hydrophobic cations, or both of these items, the distribution of the organic fluorine compound to an aqueous phase is promoted, and the organic fluorine compound is recovered.

The invention discloses a hydrofining method for optimizing the chromatic value of a bio-based terephthalic acid product, and belongs to the technical field of terephthalic acid hydrofining. The special refining process suitable for the bio-based CTA is formed by optimizing the whole process of pretreatment, hydrogenation reaction and post-treatment. The process not only solves the problem that the bio-based raw material has many impurities, but also realizes the balance of environmental protection and economy through the green solvent (water), the efficient catalyst (Pd / C) and controllable parameter design, provides a feasible path for the industrial production of bio-based PTA, and promotes the transformation of the polyester industry to sustainable development. The method provided by the invention is high in impurity removal rate, can efficiently purify the bio-based CTA to obtain a product meeting the PTA standard, is mild in reaction condition, realizes low-energy-consumption and high-stability operation under efficient catalysis, is small in process pollution, and reduces the environmental load.

The invention provides a betaine succinate eutectic crystal as well as a preparation method and application thereof, and belongs to the technical field of eutectic crystal manufacturing. The structural formula of the succinic acid betaine eutectic crystal is shown as a formula I, the molecular formula of the succinic acid betaine eutectic crystal is C28H56N4O16, in the succinic acid betaine eutectic crystal, the molar ratio of succinic acid to betaine is 1: 2, and the succinic acid betaine eutectic crystal has low irritation and excellent effects.

The invention discloses a method and a system for efficiently producing short-chain fatty acid by utilizing waste molasses in the sugar industry and municipal sludge through synergistic anaerobic fermentation, and belongs to the technical field of organic solid waste recycling. Waste molasses and municipal sludge are mixed according to a specific ratio, the carbon-nitrogen ratio is optimized to 20-30: 1, trace metal catalysts (Fe < 2 + >, Co < 2 + > and Ni < 2 + >) are added, and two-stage pH regulation (the initial pH is 6.0-7.0, and the later pH is 5.5-6.0) and a medium-temperature (35-37 DEG C) anaerobic fermentation process are combined, so that the yield of short-chain fatty acid is remarkably increased to 5.2-6.8 g COD / L and is increased by 200-300% compared with that of traditional sludge single-substrate fermentation. The method realizes recycling and high-value conversion of the organic solid waste, and has the characteristics of low cost, high acid production efficiency and environmental friendliness.

The invention discloses a preparation method of a nylon 66 salt crystal, which is characterized in that in the method, a nylon 66 salt aqueous solution is subjected to secondary crystallization and a rotary pressure filter process to prepare the nylon 66 salt crystal. According to the technology, the problems of low single-stage yield and large sewage discharge amount are solved by adopting secondary crystallization and evaporation condensate recycling, and the processes of centrifugation, drying, cyclone separation and the like are reduced by replacing a centrifugal machine with a rotary pressure filter, so that the energy consumption per ton of products is reduced.

The invention provides a method for extracting and purifying long-chain dicarboxylic acid from fermentation liquor, which comprises the following steps: (1) controlling the pH value of the fermentation liquor to be less than or equal to 5 and the density to be 0.9-1.16 g / cm < 3 > to obtain a first solid-liquid mixture; (2) centrifuging the first solid-liquid mixture to obtain a second solid-liquid mixture of which the content of long-chain dibasic acid is greater than that of other solid substances and a third solid-liquid mixture of which the content of long-chain dibasic acid is smaller than that of long-chain dibasic acid in the second solid-liquid mixture; and (3) separating the second solid-liquid mixture to obtain the long-chain dicarboxylic acid. The method is simple to operate, low in equipment requirement and investment and high in treatment efficiency. And most thalli and impurities in the fermentation liquor are removed through centrifugal separation. And the obtained product has high purity and high product yield.

The invention belongs to the technical field of impurity separation, and particularly discloses a method for separating and purifying impurities in a process for preparing glyoxylic acid through oxalic acid electrolysis, a crystallization kettle is included, an isolation device is arranged in the crystallization kettle, and the isolation device comprises a conical top cover, a conveying pipe, an annular filter screen, a directional conveying assembly and a sealing assembly; the conical top cover is arranged at the axis of the crystallization kettle, an opening of the conical top cover faces downwards, and a plurality of fixing rods are fixedly connected between the top of the conical top cover and the inner wall of the side face of the crystallization kettle. According to the method, glyoxylic acid product solutions with different concentration specifications and the high-purity glyoxylic acid crystal can be obtained after the electrolyte is sequentially subjected to pre-evaporation, electrodialysis, secondary evaporation, cooling crystallization, solid-liquid separation, washing and drying and other procedures, so that the prepared high-purity glyoxylic acid crystal can be popularized and applied in the field of high-end medicine.

The invention belongs to the technical field of preparation of electronic-grade tartaric acid, and particularly relates to a preparation method of an electronic-grade tartaric acid solution, which comprises the following steps: (1) dissolving tartaric acid to prepare a tartaric acid solution, cooling the solution to 20 DEG C, crystallizing, separating out, filtering and drying to prepare recrystallized tartaric acid; (2) preparing the recrystallized tartaric acid into a tartaric acid solution, dropwise adding the tartaric acid solution into the calcium hydroxide suspension, reacting for 2 hours to obtain a calcium tartrate solid, washing the calcium tartrate solid at 60-80 DEG C for 3 times, filtering and drying to obtain calcium tartrate; (3) preparing a 50% calcium tartrate suspension from the calcium tartrate prepared in the step (2), dropwise adding an electronic-grade concentrated sulfuric acid solution into the calcium tartrate suspension, and reacting to prepare a tartaric acid solution; and (4) performing ion exchange on the tartaric acid solution prepared in the step (3) through secondary resin to obtain the electronic-grade tartaric acid solution. The method is low in cost and easy to operate, and the maximum removal rate of metal ions reaches 99.99%.

The invention discloses equipment and a method for preparing an electronic-grade salicylic acid solution. The equipment comprises an acidification tank, an alkali tank, a micron filter, an anion filter, a cation adsorption column and a nano filter. The acidification tank is used for loading a salicylic acid solution and an acidic substance, and the alkali tank is used for loading an eluent. The method comprises the following steps: firstly, removing large impurities from a salicylic acid solution and acidic substances through a micron filter, then conveying the salicylic acid solution and acidic substances to an anion filter, adsorbing salicylic acid through anion adsorption resin to obtain phenol, removing the phenol, then introducing an eluent, washing off the salicylic acid solution, conveying the salicylic acid solution to a cation adsorption column to remove metal ions, and finally conveying the salicylic acid solution and the acidic substances to a nano filter to obtain the purified salicylic acid. And reducing the granularity of the salicylic acid solution to obtain the electronic-grade salicylic acid solution. The electronic-grade salicylic acid solution has the advantage of strong selective complexing ability to metals, and has a good wet etching effect in the integrated circuit manufacturing process.

The invention belongs to the technical field of separation of drug intermediates, and particularly relates to a control method for a process impurity 2-ethyl valeric acid (EP-B) in preparation of valproic acid or sodium valproate by a diethyl malonate method. According to the method disclosed by the invention, the content of 2-ethyl-2-propylmalonic acid process impurities in dipropylmalonic acid is controlled, so that the content of 2-ethylvaleric acid (EP-B) which is a process impurity in valproic acid or sodium valproate is accurately controlled; adding a polar solvent into the dipropylmalonic acid crude product, heating, pulping for a certain time, cooling, filtering and drying to obtain a high-purity dipropylmalonic acid refined product; high-purity valproic acid (RRT is equal to 1.00) is prepared through decarboxylation of the dipropyl malonic acid fine product, and the purity is 99.779%; 0.020% of 2-ethyl valeric acid (RRT is equal to 0.90); and valeric acid (RRT = 0.77), 0.039%. The valproic acid product quality meets the requirements of European Pharmacopoeia. According to the method, the problems of quality control and process evaluation of valproic acid or sodium valproate prepared by a diethyl malonate method are solved.

The invention discloses a preparation method of ferrous oxalate, and belongs to the field of cyanidation tailing resource utilization, and the method comprises the following steps: preparing ferrous oxalate by using ferric oxalate prepared from a cyanidation tailing leachate as a raw material; wherein the cyanidation tailing leaching solution is a leaching solution generated in a cyanidation tailing iron removal process; according to the method, the ferric oxalate prepared from the cyanidation tailing leachate is used as a raw material to prepare the ferrous oxalate, the ferric oxalate plays a role in providing a Fe < 3 + > source and C2O4 < 2-> precipitation ions in the preparation process of the ferrous oxalate, and an inorganic iron source and a precipitator oxalic acid or oxalate do not need to be purchased in the preparation process, so that the preparation cost of the ferrous oxalate is relatively low; the preparation process is simple, high-salinity wastewater is not generated, and the method is a clean technology for preparing ferrous oxalate; secondly, the prepared ferrous oxalate does not contain Cl <-> or SO4 < 2->, and the product quality is high; according to the method, ferric oxalate prepared from the cyanidation tailing leachate is used as a raw material to prepare oxalic acid, and diversified utilization of iron in the cyanidation tailings is achieved.

The invention discloses a method and a system for producing high-purity medium-chain fatty acid (MCFA) based on waste molasses two-stage regulation fermentation. Comprising the following steps: (1) diluting waste molasses, then adding a compound enzyme agent of pectinase, beta-glucanase and cellulase, and coupling microwave to assist treatment; (2) inoculating the pretreated waste molasses with a composite flora containing a clostridium kluyveri mutant strain and a Megasphaera elsdeni engineering bacterium, and carrying out a fermentation treatment on the waste molasses, wherein the composite flora contains the clostridium kluyveri mutant strain and the Megasphaera elsdeni engineering bacterium; (3) sequentially performing two-stage dynamic regulation and control fermentation on the waste molasses inoculated with the composite flora through a pH-stat control strategy to realize efficient conversion from butyric acid to hexanoic acid / octanoic acid; and (4) a hydrophobic hollow fiber membrane module is adopted to realize on-line removal of the product, and the inhibition effect of the product is relieved. According to the technology, the yield of the MCFA produced from the waste molasses reaches 0.45 g / g COD, the cost is reduced by 68% compared with that of a traditional substrate, and a new way is provided for recycling of sugar manufacturing waste.

The invention belongs to the field of medicines, and particularly relates to a pharmaceutical co-crystal of fenerenone and maleic acid and a preparation method of the pharmaceutical co-crystal. The pharmaceutical co-crystal of the fenerenone and the maleic acid prepared by the invention has the advantages of high purity, proper solubility, good stability and the like, and is suitable for new drug development and industrial production. The preparation method of the pharmaceutical co-crystal of the fenerenone and the maleic acid, provided by the invention, is simple in process route, low in cost and suitable for industrial production.

The invention provides a preparation method of nanotube-shaped BiO (CH3COO). The preparation method comprises the following steps: dispersing Bi (NO3) 3.5 H2O in a PVP (Polyvinyl Pyrrolidone) aqueous solution; adding NaAc powder into the solution, and reacting at room temperature; and after the reaction is finished, centrifuging, washing and drying to obtain the nano-tube-shaped BiO (CH3COO). The invention also provides an application of the nanotube BiO (CH3COO) as a catalyst in photocatalytic energy conversion and environment purification. The method disclosed by the invention is simple to operate, and highly crystallized nanotube-shaped BiO (CH3COO) can be obtained at room temperature only by adding a small amount of PVP (Polyvinyl Pyrrolidone); the nanotube BiO (CH3COO) shows remarkable oxidation-reduction performance on CO2 reduction coupling TC oxygenolysis under ultraviolet excitation, and is expected to have potential application prospects in the fields of energy crisis relief and industrial wastewater treatment.

This disclosure provides an optimized, energy-efficient, and sustainable solution for continuous in situ bio-based chemical recovery by integrating high pressure reverse osmosis with extraction processes. These systems achieve higher recovery efficiency while reducing production costs and environmental impact.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of butynedioic acid. The preparation method of the butynedioic acid comprises the following steps that butynediol is oxidized into the butynedioic acid through pypocholoride and a catalyst, and the catalyst comprises carbon black and a metal compound loaded on the carbon black. According to the invention, butynediol is used as a raw material, and butynediol is oxidized by using pypocholoride and a catalyst to prepare butynedioic acid. Wherein butynediol is easy to obtain, and the raw material cost is low. In addition, the catalyst uses carbon black to immobilize a metal compound, conversion of pypocholoride into a large number of reactive oxygen free radicals can be accelerated, butynediol can be efficiently oxidized under the action of pypocholoride and the catalyst, and the whole synthesis route is safe and green, simple and feasible in process, low in equipment requirement, low in operation cost, free of secondary pollution and low in production cost.