The refers to a mass production method of isobutyl acetate which uses hydric sulphate as accelerant by reaction fractional distillation, using ethyl acetate and butyl alcohol as raw material, concentrated sulfuric acid as accelerant, continue producing isobutyl acetate by reaction fractional distillation, the whole production system contains three towers, reaction fractionating tower, azeotropy tower and eater fractionating tower, the reaction fractionating tower, azeotropy tower are setted side by side. The ethyl acetate, butyl alcohol and concentrated sulfuric acid are drived into feeder column plate of reaction fractionating tower after esterification prereaction, the gas phase of prereactor going into feeding phase of reaction fractionating tower, the gas phase on top of reaction fractionating tower going into column plate of cellar of azeotropy towder, the liquid phase of towder bottom going into mesomere of eater fractionating tower, the butyl product is continue discharged from side tower. This invention combines the technique which using sulfuric as accelerant by mean improvement of reaction fractional distillation technique, not only ustilizing the advanced technology of reaction fractional distillation, but also making the liquid accelerant's characters of convenience to operate, easy to enlarge production scale getted adequate use.