12010results about How to "Promote recovery" patented technology

Systems for bone and spinal stabilization, fixation and repair include intramedullar nails, intervertebral cages and prostheses, remotely activatable prostheses, tissue extraction devices, and electrocautery probes. The intramedullar nails, intervertebral cages and prostheses, are designed for expansion from a small diameter for insertion into place to a larger diameter which stabilizes, fixates or repairs the bone, and further can be inserted percutaneously. Remotely activatable prostheses can be activated from an external unit to expand and treat prosthesis loosening. Tissue extraction devices, and electrocautery probes are used to remove tissue from desired areas.

Disclosed are methods and compositions for producing heterologous disulfide bond containing polypeptides in bacterial cells. In preferred embodiments the methods involve co-expression of a prokaryotic disulfide isomerase, such as DsbC or DsbG and a gene encoding a recombinant eukaryotic polypeptide. Exemplary polypeptides disclosed include tissue plasminogen activator.

A knee prosthesis, methods of implanting the prosthesis, method of treating arthritis of the knee, and a kit therefore are provided. The prosthesis answers many of the limitations of current knee prosthetic devices by providing a two-component (or alternatively, an optional three-component) device, as either a single structure, or as separate pieces. One of the components is constructed of low friction material, while the second is composed of a weight-dissipating cushioning material; the optional third component is constructed of low friction material. The prosthesis is initially attached to surrounding soft tissue in the knee by biodegradable sutures; it is held permanently in place by fibrous ingrowth into a porous collagen rim in the cushioning component. Major improvements provided by the present invention over currently available prostheses include minimal incisions, minimal or no bone cuts, minimal overall dissection (these improvements lead to shorter hospital stays and rapid rehabilitation and fewer potential for side effects), less prosthetic wear, greater longevity, fewer activity restrictions, able to be used on young, large, active patients, ease of revision, ease of conversion into a total knee arthroplasty if needed.

Devices and methods are provided for the treatment of glaucoma. An ocular implant is adapted such that aqueous humor flows controllably from the anterior chamber of the eye to Schlemm's canal, bypassing the trabecular meshwork. The implant may utilize one or more bioactive agents effective in treating glaucoma or other pathology.

The invention relates generally to medical devices and methods for reducing the intraocular pressure in an animal eye and, more particularly, to stent type devices for permitting aqueous outflow from the eye's anterior chamber and associated methods thereof for the treatment of glaucoma. Some aspects provide a self-trephining glaucoma stent and methods thereof which advantageously allow for a “one-step” procedure in which the incision and placement of the stent are accomplished by a single device and operation. This desirably allows for a faster, safer, and less expensive surgical procedure.

Methods, apparatus and computer programs have been provided for mitigating a problem of non-optimal recovery from storage device failures. A method involves determining a required write performance for rebuilding data of a failed device, based at least partly on the potential read performance of storage devices in a data rebuild; and allocating a virtual storage area within available storage, which allocation of virtual storage is based at least partly on the required write performance. Data is rebuilt by writing to the allocated virtual storage area, and data recovery is completed by migrating this rebuilt data to at least one data storage device such as a spare physical storage device within the array.

This invention describes methods of using anti-B cell antibodies, preferably anti-CD20 antibodies, and most preferably Rituximab, to treat B cell lymphomas of the brain, especially primary central nervous system lymphomas (PCNSLs), and to prevent meningeal relapse. The antibodies can be administered intrathecally alone, or in combination with other chemotherapeutics, such as methotrexate, or other anti-B cell antibodies to treat PCNSL in both immunocompromised and non-immunocompromised patients. These antibodies can also be used to diagnose patients with CNS lymphoma, especially in immunocompromised patients.

The present invention provides an improved alkali metal catalyzed steam gasification process that utilizes a CO₂ trap material and/or a mineral binder material within the gasifier. The process optimally achieves over 90% carbon conversion with over 80% yield of methane. The raw gas product can be used directly as fuel. The catalyst can be recovered from the solid purge and recycled to the gasifier and/or the CO₂ trap can be regenerated and recycled to the gasifier.

The invention relates to methods and compositions for the differentiation of stromal cells from adipose tissue into hematopoietic supporting stromal cells and myocytes of both the skeletal and smooth muscle type. The cells produced by the methods are useful in providing a source of fully differentiated and functional cells for research, transplantation and development of tissue engineering products for the treatment of human diseases and traumatic tissue injury repair.

The present invention provides for a method, system, and computer program for the application of data deduplication according to a policy-based strategy of tiered data. The method operates by defining a plurality of data storage policies for data in a deduplication system, policies which may be arranged in tiers. Data objects are classified according to a selected data storage policy and are split into data chunks. If the selected data storage policy for the data object does not allow deduplication, the data chunks are stored in a deduplication pool. If the selected data storage policy for the data object allows deduplication, deduplication is performed. The data storage policy may specify a maximum number of references to data chunks, facilitating storage of new copies of the data chunks when the maximum number of references is met.

A switching apparatus is disclosed that employs a relatively simple and inexpensive switching matrix, but which avoids interruption of existing connections when connections are added or removed. The switching matrix switches errorlessly by controlling the point in time at which switching occurs. Using such a technique, switching can be performed without disturbing the connections already configured in the switching matrix, and so is referred to herein as being non-blocking. Optionally, the incoming data can be rearranged to provide a larger window of time in which the switching matrix can be switched. In the case of a switch using an optical backplane, this also allows more time for various components of the system (e.g., clock/data recovery units) to re-acquire lock. The switching apparatus includes a switching matrix and control circuitry. The switching matrix has a matrix input, a control input and a number of matrix outputs, and is configured to receive an information stream at the matrix input. The information stream includes a number of portions, while the control circuitry has a control output coupled to the control input. The control circuitry is configured to initially configure the switching matrix to output the information stream at a one of the matrix outputs and to subsequently configure the switching matrix to output the information stream at another of the matrix outputs during a period of time during which the one of the portions is transiting the switching matrix.

A storage management device records write requests that are directed to a data store. In one embodiment, the storage management device records a plurality of write request entries, each one of which includes information relating to a write request, in at least one first database table, and maintains, for each first database table, at least one record in a second database table. The one or more records in the second database table include data representing the effects of the write requests on a state of at least one portion of the data store. In one such embodiment, each time that one write request entry is recorded in one first database table, the storage management device updates at least one record in the second database table.

Disclosed are methods for the isolation and purification of high-titer recombinant adeno-associated virus (rAAV) compositions. Also disclosed are methods for reducing or eliminating the concentration of helper adenovirus in rAAV samples. Methods are disclosed that provide highly-purified rAAV stocks having titers up to about 10<13 >particles/ml at particle-to-infectivity ratios of less than 100 in processes that are accomplished about 24 hours or less.

An apparatus including a first device at a vehicle or premises and capable of controlling one or more of a plurality of a system, equipment system, component, device, equipment, and/or appliance. The first device generates and/or transmits a first signal for controlling the system, equipment system, component, device, equipment, and/or appliance. The first device generates and/or transmits the first signal in response to a second signal generated by and/or transmitted from a second device located remote from the vehicle or premises. The second device generates and/or transmits the second signal in response to a third signal generated by and/or transmitted from a third device located remote from the vehicle or premises and the second device. The third signal is transmitted on or over the Internet and/or the World Wide Web.

A bone resection tool for resecting an end of a bone along a surface having a curvature comprises a guide, a cutting tool and a track follower. The guide is configured to be removably attached in a fixed position to the end of the bone. The guide is configured to include a track exhibiting a curvature generally corresponding to the curvature of the surface to be resected in the bone. The cutting tool includes a cutting face. The track follower is configured to couple to the cutting tool and cooperate with the track to facilitate reciprocation of the cutting tool relative to the guide to induce the cutting face to resect the bone along the surface having the curvature. A method for cutting a bone along a curved surface conforming to the curvature of a curved surface of the underside of a prosthetic component comprises the steps of incising the tissue surrounding the surface of the bone, positioning a guide alongside the surface of a bone to be cut, affixing the guide to the bone, interconnecting a cutter having a cutting face with the guide, maintaining the cutting face generally parallel to the tangent of the curved surface and traversing the cutting face along the bone while guiding the cutter along the track. The tissue incision incises the tissue surrounding the surface of the bone to be cut in a minimally invasive fashion. The positioned guide includes a track configured to assimilate the curvature of the curved surface of the underside of the prosthetic component.

Methods and apparatus are provided for valve repair or replacement. In one embodiment, the apparatus is a valve delivery device comprising a first apparatus and a second apparatus. The first apparatus includes a heart valve support having a proximal portion and a distal portion and a heart valve excisor slidably mounted on said first apparatus. The second apparatus includes a fastener assembly having a plurality of penetrating members mounted to extend outward when the assembly assumes an expanded configuration; and a heart valve prosthesis being releasably coupled to said second apparatus. The first apparatus and second apparatus are sized and configured for delivery to the heart through an opening formed in a femoral blood vessel. The heart valve prosthesis support is movable along a longitudinal axis of the device to engage tissue disposed between the anvil and the valve prosthesis. The system may include a tent and/or an embolic screen to capture debris from valve removal.

A method of increasing the growth of stem cells by mixing the stem cells with a growth medium that has been conditioned by an incubation with placental tissue. The method increases the expansion of the stem cell population.