40 results about "Trabecular meshwork" patented technology

The invention discloses an application of a sophora flavescens ethyl acetate part and an active component thereof in resisting glaucoma trabecular meshwork fibrosis, relates to the field of biological medicines, and innovatively discovers the effect of the sophora flavescens ethyl acetate part and the active component thereof in resisting glaucoma trabecular meshwork fibrosis. The compound can be applied to preparation of drugs for resisting trabecular meshwork cell fibrosis and preventing and treating trabecular meshwork cell fibrosis related diseases such as glaucoma.

A system includes a light source configured to emit treatment light and an optical coherence tomography (OCT) device. The system further includes a surgical instrument including a distal portion configured to be inserted into an eye of a patient. An optical fiber is coupled to the light source and to the OCT device and (a) conducts the treatment light along the distal portion to be emitted from a tip of the distal portion and (b) conducts detection light from the OCT device along the distal portion to be emitted from the tip of the distal portion and conduct a reflected portion of the detection light to the OCT device. A controller obtains image data from the OCT device and operates the light source per the image data, e.g., selects a number of pulses for the treatment light based on a thickness of a trabecular meshwork apparent in the image data.

The present disclosure describes an optical probe for applying a laser light to at least the flat portion of the ciliary body and optionally other areas, such as the trabecular mesh, the ciliary crown and / or the ciliary sulcus of the eye, the present invention relates to methods, such as for treating glaucoma, reducing intraocular pressure (IOP), improving the outflow of aqueous humor from the eye, and / or reducing the accumulation of aqueous humor within the eye. The optical probe may be adapted for simultaneous treatment of a plurality of different regions, tissues, or eye bodies of the eye, or for sequential treatment of a plurality of different regions, tissues, or eye bodies of the eye.

The present disclosure pertains to the field of animal disease models, specifically to a method for constructing an animal model of open-angle glaucoma. In this model, the pathogenesis of open-angle glaucoma is mimicked by inducing necroptosis in trabecular meshwork cells through the injection of IFN-γ into the anterior chamber. This process leads to the inhibition of trabecular meshwork activity and functional impairment, resulting in elevated intraocular pressure and subsequent optic nerve changes indicative of glaucoma. The pathophysiological alterations observed in the animal model closely resemble those seen in human open-angle glaucoma, including chamber angle opening, trabecular meshwork dysfunction, increased intraocular pressure, and loss of RGCs.

The invention discloses application of an umbilical cord blood exosome in preparation of a medicine for treating ophthalmic diseases caused by aging. It is found that the umbilical cord blood exosome can improve the biological characteristics of senescent trabecular meshwork cells, relieve the senescence characteristics of the trabecular meshwork cells, improve the DNA damage repair capacity of the cells, promote proliferation of the trabecular meshwork cells and effectively maintain the stability of cell nucleuses, and then growth and division of the cells are supported. The umbilical cord blood exosome shows a remarkable anti-aging effect in treatment of ophthalmic diseases caused by aging, can effectively improve the biological function of trabecular meshwork cells, slow down the aging process and promote cell proliferation and repair, and has wide application potential.

Provided is an ophthalmic surgery instrument that allows an instrument suitable for excising a trabecular meshwork to be configured and allows a grip portion to be used for both first ophthalmic surgery such as trabeculectomy and second ophthalmic surgery. A first passage and a second passage for performing suction or supply of a perfusate are formed in a grip portion of an ophthalmic surgery instrument. An internal thread portion is formed at a tip end of the grip portion. A tip end member for first ophthalmic surgery has a single passage therein, and has a bent-shaped blade portion and an opening of the passage at a tip end thereof. The tip end member for first ophthalmic surgery and a tip end member for second ophthalmic surgery are selectively screwable to the internal thread portion.

This invention relates to a biopsy needle for trabecular meshwork tissue of the eye, belonging to the field of medical device technology. It solves the problem of large incisions caused by the large surgical incisions in traditional trabeculectomy procedures, where a scalpel is used to cut a block of ocular tissue containing the trabeculae and deep cornea and sclera. The invention includes a needle, a scraper unit, and a handle. The needle is connected to the handle, the scraper unit is disposed within the needle, and the handle is for the user to hold. The needle is inserted into the patient's eyeball, and the scraper unit is used to cut the trabecular meshwork and Schlemm's canal wall tissue. The scraper unit of this invention is a bendable scraper unit. The first, second, and third sections can form grooved hooks for hooking the trabecular meshwork and Schlemm's canal wall tissue. The grooved hooks of this invention are specifically designed to hook the trabecular meshwork and Schlemm's canal wall tissue, resulting in minimal trauma to the ocular incision.

The present invention discloses an intraocular implant delivery device, which includes a housing, a main control pull rod assembly, a slider assembly, a striking assembly, a needle retracting turntable and a needle pushing assembly. The main control pull rod assembly, the slider assembly, the striking assembly and the needle retracting turntable are all arranged inside the housing. A through hole is provided at the distal end of the housing, and the needle of the needle pushing assembly passes through the through hole and extends to the outside of the housing. Energy sources capable of selectively releasing energy are arranged on the main control pull rod assembly, the slider assembly and the striking assembly; the main control pull rod assembly is actuated by an operator through a button arranged on the housing, so that a spring drives the main control pull rod assembly to move axially; for the intraocular implant delivery device of the present invention, only one puncture is required to repeatedly deliver implants to the trabecular meshwork of a patient for multiple times, improving the efficiency of the implant surgery and enabling higher implant accuracy of the implants; the present invention can effectively overcome the problems of empty firing of implants or firing two implants at a time caused by low grasping accuracy of the needle pushing.

The invention relates to a pathological biopsy needle for eye trabecular meshwork tissue, belongs to the technical field of medical instruments, and solves the problem that in the traditional trabectomy in the prior art, an eye tissue block containing trabecula and deep sclera is cut by a surgical blade, and the trauma of an eye incision is large. The device comprises a needle head, a scraper unit and a handle, the needle head is connected with the handle, the scraper unit is arranged in the needle head, the handle is used for being held by a user, the needle head is used for being inserted into an eyeball of a patient, and the scraper unit is used for cutting trabecular mesh and Schlemm tube wall tissue. The scraper unit is a bendable scraper unit, the first section, the second section and the third section can form a hook part with a groove, and the hook part with the groove is used for hooking trabecular meshes and Schlemm pipe wall tissues. The hook part with the groove is specially aligned to trabecular meshes and Schlemm tube wall tissues for hooking, and the trauma of an eye incision is small.

The invention relates to application of a reagent for inhibiting STAT3 gene expression in treatment of oxidative damage of trabecular meshwork cells. According to the invention, a signal channel STAT3 to EIF4E to TGF-beta-SMAD < 2 / 3 > for regulating and controlling the oxidative damage of the trabecular meshwork cells is innovatively found, and the STAT3 activates the TGF-beta-SMAD < 2 / 3 > channel by combining with EIF4E3, so that the apoptosis, oxidative stress and fibrosis of the trabecular meshwork cells caused by the oxidative damage are promoted. After the expression of the STAT3 gene in trabecular meshwork cells is inhibited, the EIF4E3 level can be reduced, and the apoptosis, oxidative stress and fibrosis of the trabecular meshwork cells induced by EIF4E3 are improved. Therefore, a reagent for inhibiting STAT3 gene expression can be used for treating trabecular meshwork cell oxidative damage and eye diseases related to the trabecular meshwork cell oxidative damage, including glaucoma and the like.

An ab externo automated laser treatment system for treating an eye in a subject, includes a non-contact laser source configured to generate a laser beam having at least one wavelength to treat the eye by directing the laser beam from a location spaced from the eye, wherein the at least one wavelength is a near-infrared wavelength in the range of about 0.5-2.2 μm, a laser scanner optically coupled to the non-contact laser source to receive the laser beam from the non-contact laser source and to scan the laser beam relative to the eye, and a processor, and memory including stored computer-readable instructions that, responsive to execution by the processor, cause the laser treatment system to direct the laser beam to a plurality of trans-scleral treatment locations to be irradiated in a predetermined treatment pattern on an external surface of the eye, wherein the trans-scleral treatment locations are 0-4 mm posterior to the corneolimbal junction, and wherein the laser beam is repetitively directed to the same irradiated trans-scleral treatment locations on the surface of the eye, and the trans-scleral treatment locations are irradiated at intervals sufficient to induce protective thermal preconditioning and therapeutic bio-stimulation of one or more of the trabecular meshwork and / or ciliary body without photocoagulation of the tissue of the eye. Trans-pupillary systems, patient interfaces, and methods are also disclosed.

This invention belongs to the field of biomedical technology, specifically relating to an engineered exosome and its applications. This invention is the first to discover that PCDH12 is specifically highly expressed in the trabecular meshwork tissue of glaucoma patients. Based on this target, engineered exosomes loaded with PCDH12 antibodies were successfully developed. These engineered exosomes can achieve non-invasive and precise targeted delivery to the trabecular meshwork tissue. In glaucoma model mouse experiments, they not only significantly reduced intraocular pressure but also effectively protected the optic nerve. The non-invasive and precise delivery strategy proposed in this invention combines potent intraocular pressure reduction with direct neuroprotection, providing a candidate solution with direct clinical translational potential for integrated "pressure reduction-neuroprotection" treatment of glaucoma.

To provide apparatus and methods for treating glaucoma in a patient's eye (25).SOLUTION: A treatment laser beam is directed at the trabecular meshwork of the patient's eye to initiate reactions that promote improved drainage of aqueous humor fluid.SELECTED DRAWING: Figure 3a

The present invention belongs to the field of biotechnology, and discloses a capsid protein mutant that improves the infectivity of AAV to eye tissues and its application. By inserting AAVRFDGTERAA and RQYSDAVRAE at amino acid positions 587 and 588 corresponding to the wild-type AAV2 virus capsid protein, the capsid protein mutants AAV2-NE01 and AAV2-NE02 are obtained. The virus yields of AAV2-NE01 and AAV2-NE02 are 1.96 times and 1.20 times that of AAV2-WT. After intravitreal injection, they can preferably infect various layers of cells from the ganglion cell layer (GCL), inner nuclear layer (INL) to outer nuclear layer (ONL) of the NHP retina and the trabecular meshwork region, with a high infection positive rate, strong fluorescence intensity, strong retinal penetration ability, and can infect the nuclear part and inner segment of the optic nerve. It has good application prospects and is expected to be developed into an AAV vector for treating eye diseases.

The present invention relates to an ophthalmic knife that uses minimally invasive surgical techniques to treat various conditions including eye diseases, such as glaucoma. The present invention relates to a multi-blade device for cutting tissue within the eye, such as the trabecular meshwork (TM).

The invention belongs to the technical field of biological medicine, and particularly relates to a soluble microneedle patch for in-situ drug delivery of trabecular meshwork tissue and a preparation method and application of the soluble microneedle patch. The soluble microneedle patch comprises a fan-ring-shaped backing and a microneedle array arranged on the fan-ring-shaped backing; the micro-needle and the fan-ring-shaped backing are both prepared from polyvinyl alcohol (PVA), the PVA concentration for preparing the micro-needle and the fan-ring-shaped backing is 5%-25%, and the PVA concentration is obtained by weighing 0.5 g-2. 5 g of PVA powder and dissolving the PVA powder in 10 mL of pure water or PBS. The microneedle patch is suitable for delivery of various types of drugs, is expected to be used for treatment of various eye diseases including glaucoma, ocular hypertension, cataract, uveitis, conjunctivitis, xerophthalmia and the like, and has important clinical application value and commercial value.

The invention discloses an application of 6-CEPN in preparation of a product for preventing and improving osteoporosis. According to the invention, ovariectomized mice are fed with two doses of 6-CEPN, which discovers that the 6-CEPN can obviously inhibit abnormal weight increase of the mice caused by estrogen decrease and can also improve bone microstructure of the ovariectomized mice; the bone trabecula network structure is adjusted by increasing the bone trabecula connection density, the bone trabecula number and the bone trabecula thickness and reducing the separation degree of the bone trabecula, meanwhile, 6-CEPN can further increase the bone density and the bone volume fraction of ovariectomized mice, increase the rigidity and deflection of bones and improve the bone strength, the effect of high-dose 6-CEPN is larger than that of low-dose 6-CEPN, and the effect of high-dose 6-CEPN is better than that of low-dose 6-CEPN. Therefore, the composition has a dose-dependent effect.

The application discloses a kind of drugs for treating glucocorticoid glaucoma.The application finds by experiment, Rho kinase inhibitor can inhibit RhoA-ROCK signal pathway, destroy glucocorticoid-induced cytoskeleton remodeling and reduce extracellular matrix deposition.At the same time, 10 μM or less concentration, no toxic side effects to cell growth, while significantly inhibiting RhoA-ROCK signal pathway.The experimental results suggest that RKI1447 can change the morphology of trabecular meshwork cells and inhibit cell migration, thereby regulating aqueous humor drainage, reducing intraocular pressure, and thereby treating glucocorticoid glaucoma.The application provides the application of Rho kinase inhibitor RKI1447 in the preparation of glucocorticoid glaucoma drugs.

The present invention relates to therapies for ocular diseases or disorders in an individual. Provided herein are methods of delivering nucleic acid vectors to ocular cells (e.g., corneal endothelium, trabecular meshwork, etc.) in an anterior segment of an eye involving methods of administering nucleic acid vectors to an individual and methods of electrotransferring nucleic acid vectors to express a therapeutic transgene. Nucleic acid vectors for use in ocular diseases, such as Fukes dystrophy, are also provided.

The invention relates to the technical field of medicines, in particular to application of flos lonicerae and an extract thereof in preparation of a medicine for treating glaucoma. According to the application, the effects of the lonicera confusa extract and the active ingredients thereof on resisting trabecular meshwork cells and trabecular meshwork fibrosis are found, and the lonicera confusa extract and the active ingredients thereof can be applied to preparation of drugs for resisting trabecular meshwork fibrosis and preventing and treating trabecular meshwork fibrosis related diseases such as glaucoma. The invention relates to applications of lonicera confusa extract, chlorogenic acid, isochlorogenic acid A, dipsacus asper saponin B and macranthoidin B in preparation of drugs for resisting trabecular meshwork cell and animal fibrosis, and also can be used for preparing drugs for inhibiting up-regulation of FN, alpha-SMA and COL-1 protein levels and drugs for inhibiting up-regulation of transcription levels of FN1, ACTA2, COL1A1 and COL4A1, and particularly relates to applications of the lonicera confusa extract, chlorogenic acid, isochlorogenic acid A, dipsacus asper saponin B and macranthoidin B in preparation of drugs for resisting trabecular meshwork cell and animal fibrosis. Good patent medicine potential and wide development, transformation and clinical application values and prospects are realized.

The invention provides a personalized eyeball model establishment method suitable for finite element simulation, and relates to the technical field of finite element simulation, and the method specifically comprises the steps: importing an eye OCT image into three-dimensional modeling software, and obtaining structural information; an ellipse is drawn based on the information, the long axis is the length of the equatorial part of the eyeball, and the short axis is twice the distance from the equatorial part to the posterior pole; a quarter of the upper right portion of the cut ellipse is reserved, and the cut ellipse is offset outwards by 1 mm to form an equatorial posterior sclera outline; drawing an eye axis straight line and a cornea thickness straight line, zooming and moving the OCT image to enable the OCT image to coincide with the cornea thickness straight line; drawing a cornea contour and a trabecular mesh contour according to the OCT image, and forming sclera vein sinus after biasing; and symmetrically drawing to obtain a complete section, and rotating by 360 degrees to generate a three-dimensional eyeball model. The method is based on common ophthalmic examination data, is easy to obtain, has high accuracy, can significantly improve the authenticity and precision of the model, and improves the prediction accuracy of ophthalmic diagnosis and treatment.

The application discloses application of tsRNA00527 in preparation of a product for treating glaucoma, and the application can block a TWEAK / NF-kappa B signal path, regulate ECM remodeling, improve AH outflow, and significantly reduce IOP, and has a significant curative effect on glaucoma. In addition, the application also provides a nanoparticle loaded with the tsRNA00527, the nanoparticle can be effectively taken up by immortalized human trabecular meshwork cells, and has good targeting, biocompatibility and treatment effect on glaucoma.

The present application relates to the technical field of biological medicine, and in particular to a reagent for regulating an ALKBH5-ABCA1 axis and application of the reagent in preparation of a drug for treating glaucoma, wherein the reagent at least includes any one of a reagent for promoting expression of ALKBH5, a reagent for promoting expression of ABCA1, a reagent for inhibiting expression of METTL3, and a DNA methyltransferase inhibitor for a promoter region of ALKBH5 gene.The present application provides a reagent for targeting activation of ABCA1 or a reagent for specifically targeting delivery of ALKBH5 mRNA to a trabecular meshwork, and the reagents can effectively reverse lipid metabolism defects and significantly reduce intraocular pressure.The present application not only provides a novel treatment target based on epigenetics and metabolism for glaucoma, but also realizes a proof of concept of LNP-mRNA intraocular pressure reduction technology for the first time, and has a very high clinical conversion value.

A method of treating an ophthalmic patient includes determining that the patient is at risk of developing glaucoma during a preoperative analysis of the patient. The method further includes treating the patient with an excimer laser to prophylactically treat glaucoma based on a preoperative analysis that the patient has a risk of developing glaucoma. The systems and methods also involve treating a patient with closed-angle glaucoma or narrow-angle glaucoma using an excimer laser unit. Systems and methods also relate to a combined excimer laser and phacoemulsification unit for treating the eye. The systems and methods also involve applying excimer laser energy in lateral placement with respect to the scleral venous sinus in the eye.

The present invention provides the application of menRNA in screening and / or preparing drugs for treating the damage of trabecular meshwork tissue remodeling, and the sequence of the menRNA is shown as SEQ ID NO.1. Through comparison, it is first discovered in the present invention that the expression level of menRNA in iPSC-TM cells is significantly higher than that in pTM cells. Further experiments confirm that overexpression of menRNA has the function of promoting the assembly of paraspeckles, and plays a role in promoting cell proliferation and cell reprogramming, laying a foundation for subsequent research on the diagnosis and treatment methods of primary open-angle glaucoma and exploring the pathogenesis of primary open-angle glaucoma.

The present application relates to the technical field of trabecular meshwork fenestration surgery, and discloses a method and device for predicting intraocular pressure parameters after trabecular meshwork fenestration surgery, which is based on a phase optical coherence imaging method to obtain the trabecular meshwork elasticity parameters of different sections in the patient's eye and the three-dimensional reconstructed intravenous image of the trabecular meshwork; the fluid collection tube features are extracted from the three-dimensional reconstructed intravenous image of the trabecular meshwork; the trabecular meshwork elasticity parameters and the fluid collection tube features are input into a trabecular meshwork tissue constitutive model to determine the target fenestration position of the trabecular meshwork, so as to simulate the trabecular meshwork fenestration surgery operation; based on the simulation result of the trabecular meshwork fenestration surgery operation, the intraocular pressure parameters after the trabecular meshwork fenestration surgery corresponding to the target fenestration position of the trabecular meshwork are predicted, and therefore, the success rate of the trabecular meshwork fenestration surgery can be finally improved.

The utility model discloses a chamber corner separating and cutting integrated knife, which comprises a handle, a knife handle, a knife handle and a knife handle, a cutter body is formed at the tail end of the cutter bar; the cutter body comprises a connecting section, a flat blade section and a cutter tip; one end of the connecting section is connected with the cutter bar, and the other end forms the flat blade section; the flat blade section is formed by combining two blades parallel to each other in the length direction, and the tail ends of the blades incline upwards and intersect to form a blade tip. The cutting edges are formed on the connecting section and connected in a circular arc transition mode. The anterior chamber angle cutting device is simple in structure and convenient to operate, chamber angle separation can be completed through the flat blade section in an anterior chamber under an anterior chamber angle mirror or an endoscope, then the knife point on the front portion of the flat blade section penetrates into a trabecular mesh and the inner wall of a Schlemm tube, and the chamber angle is cut in the moving direction of the Schlemm tube. The anterior chamber is only required to enter and exit once during operation, surgical instruments do not need to be replaced, the treatment effect is good, and the cost performance is higher.

The invention discloses an application of a proliferation-related 1-like 1 protein (SIPA1L1) as a drug target in preparation of a drug for preventing and / or treating glaucoma, and relates to the technical field of medical treatment. The present invention proposes that SIPA1L1 is elevated in human trabecular meshwork (TM) cells treated by aqueous humor and transforming growth factor-beta2 (TGF-beta2) in patients with primary open-angle glaucoma, which SIPA1L1 not only promotes the production of extracellular matrix (ECM) proteins in these cells, but also inhibits the degradation of ECM proteins by inhibiting phagocytosis. The SIPA1L1 disclosed by the invention is an important factor for regulating HTM cell biological functions, which has important significance on the pathogenesis of glaucoma and the treatment of glaucoma, in addition, the proliferation-related 1-like 1 protein (SIPA1L1) disclosed by the invention can be used as a drug target for preventing and / or treating other eye diseases. The method has a wide application prospect.

The invention discloses an eye implantation drainage device and a conveying system thereof. The eye implantation drainage device comprises a head end, a connecting tube and a base which are connected in sequence, the eye implantation drainage device is provided with a drainage channel which is sequentially communicated with the head end, the connecting pipe and the base. A plurality of first connecting holes are formed in the side wall of the head end, and each first connecting hole is communicated with the drainage channel; a plurality of second connecting holes are formed in the side wall of the base, and each second connecting hole is communicated with the drainage channel; the head end is gradually thinned in the direction away from the base, and the head end is used for being inserted into a trabecular net through the anterior chamber of the eyes; the base is then at least partially residing in the anterior chamber of the eye. By the adoption of the eye implantation drainage device, the blocking probability of the eye implantation drainage device can be reduced, and then the use reliability of the eye implantation drainage device is improved.

The utility model discloses a device capable of forming an opening in the trabecular meshwork of the eye, comprising a handle, a cutting element, a sheath tube and a pushing element, the cutting element comprises an elongated rod and two cutting blades, the tail of the elongated rod is fixedly connected with the head of the handle, and the head of the elongated rod is connected with the two cutting blades; the two cutting blades are symmetrically arranged with a predetermined opening, and the head of each cutting blade has a cutting part capable of penetrating into the trabecular meshwork and cutting the trabecular meshwork; the sheath tube is sleeved on the elongated rod and can slide along the elongated rod; the pushing element is connected with the handle and can drive the sheath tube to move towards the direction of the two cutting blades, so that the two cutting blades are closed to each other under the extrusion of the sheath tube to cut the trabecular meshwork, the cut tissue is easy to be peeled off from the trabecular meshwork, the cut part of the trabecular meshwork can form a trabecular meshwork opening, and the aqueous humor in the anterior chamber is promoted to flow out of the trabecular meshwork opening to reduce the intraocular pressure; and the size of the trabecular meshwork opening can be controlled during the cutting process.