91 results about "Dosimetry" patented technology

A dose feedback system provides real-time or near real-time intra-operative radiation dose feedback system to improve and / or ensure that a proper amount of radiation is delivered to a patient by, for example, carriers (e.g., tile carriers). The dose feedback system can be implemented during medical surgeries, operations, procedures, etc. The dose feedback system may allow a medical professional (e.g., surgeon) to more accurately achieve a prescribed radiation of a dosimetric intent or a more detailed dosimetric plan through adjustments to position, dose, quantity, etc. of carriers prior to terminating the medical procedure (e.g., cavity of tumor bed is closed and / or patient is brought out from under anesthesia) at which point adjusting the radiation dose may be difficult or impossible.

Carriers for embodying radioactive seeds, as well as a device for loading and customizing brachytherapy carriers based on the principles of optimizing a more precise and predictable dosimetry, and adaptable to the geometric challenges of a tumor bed in a real-time setting. The present disclosure relates to a specialized loading device designed to enable a medical team to create a radionuclide carrier for each patient and tumor reliably, reproducibly and efficiently.

Device for personalized radiotherapy using AI-controlled dosimetry, comprising: - a patient data acquisition unit configured to receive real-time data on patient-specific health information, including medical imaging data from the patient's CT, MRI and PET scans, biometric data from wearable or hospital-grade monitoring devices, electronic health records (EHRs) and previous treatment history; - The medical image processing unit, which analyzes and processes the captured image data, performs various functions, from tumor segmentation and identification of organs at risk to the spatial alignment of multimodal images for radiotherapy planning; - a CPU is configured to preprocess other collected data by (a) normalizing imaging and physiological data, (b) aggregating imaging and physiological data, (c) encoding imaging and physiological data for subsequent analysis, and (d) ensuring the compatibility and consistency of data from different sources; - an artificial intelligence (AI) controlled dosimetry machine that is communicatively connected to the central processing unit, wherein the AI-controlled dosimetry machine is configured to use machine learning algorithms to evaluate patient-specific parameters, optimize the distribution of a radiation dose and predict responses to treatment; - a visualization and treatment planning interface coupled with the AI-driven dosimetry machine, the visualization interface being configured to provide radiation dose distributions, patient-specific treatment recommendations, and comparative dose plans that enable data-driven adjustments by clinicians; and - a visualization interface with a feedback mechanism that allows real-time input from practicing clinicians and continuous automatic recording of patient response, which is used for iterative improvement of both the dosimetry model and the treatment plan.

The present disclosure relates to a radiopharmaceutical compositions, methods, and kits comprising 177Lu-PSMA I&T. The compositions, methods, and kits may have a molar ratio of the PSMA I&T to 177Lu from greater than 8.0:1.0 to 11.0:1.0. The composition may be formulated as a solution for injection and the solution is suitable for administration at least 72 hours after formulation. The composition(s) have a radiochemical purity (RCP) of 95% or greater, 95.5% or greater, 96% or greater, 96.5% or greater, 97% or greater, 97.5% or greater, 98.0% or greater, 98.5% or greater, 99% or greater, or 99.5% or greater at administration.

The present invention provides a phantom assembly for placement of implant structures (e.g., solid tumor and normal organ surrogates) and / or optional imaging fluids (e.g., liquid or gel) for diagnosis and treatment planning. The present invention provides a capsule receiving cavity inserts allowing for the placement of implant structures, radiation detectors / measurement devices, imaging fluids, and the like within the capsule for image quality evaluation, target localization, treatment planning, and dosimetry measurements. The present invention may incorporate motion components to enable motion-resolved experimentation in imaging and radiation therapies.

The invention relates to the technical field of tumor radiotherapy, and discloses a radiotherapy parameter intelligent recommendation method based on disease species, target area volume and dose characteristics, and the method comprises the steps: firstly obtaining historical helical tomography radiotherapy data containing different disease species and dose schemes, and carrying out the standardization; then, non-iterative forward dose calculation based on full-factor experimental design is executed, and treatment simulation plans are generated in batches; then, dosimetry and efficiency indexes are extracted, and an optimization rule base containing a response surface model and a Pareto optimal solution set is constructed; and finally, processing new case features by using a decision tree model, and outputting a recommended collimator mode, a screw pitch, a modulation factor value and an expected index range. According to the method, data, a model and a decision closed loop are constructed, so that the defects that the traditional plan design depends on artificial experience, the trial and error cost is high and multiple targets are difficult to balance are overcome, and the efficiency and the quality consistency of the radiotherapy plan design are remarkably improved.

A plate for fixating bone, the plate comprising: a plurality of ribs defining a plurality of openings, wherein a first portion of the plurality of ribs define a lattice structure and a second portion of the plurality of ribs define at least four mounting holes. Another aspect of the present disclosure relates to a method for tailoring a plate for fixating bone. The method can include determining an initial design of the plate. The method can include analyzing radiation through the initial design. The method can include determining, based on analyzed radiation, if dosimetric characteristics are desirable. The method can include analyzing structural strength of the initial design. The method can include determining, based on the analyzed structural strength, if structural strength is sufficient.

Various devices, systems, and methods for performing personalized dosimetry of a patient receiving a radiopharmaceutical are described. In an example method, anatomic data is generated by performing a computed tomography (CT) scan on the patient when they are lying down and wearing a garment. Based on the anatomic data, locations of organs of the patient are determined with respect to one or more fiducial markers integrated with the garment. Detectors for detecting photons from a radiopharmaceutical are placed on the garment based on locations of the organs. Subsequently, the patient may be administered a dose of the radiopharmaceutical. When the patient wears the garment, the detectors may detect photons released from the decaying radiopharmaceutical that is distributed in the organs. The radiation dosage to the organs may be determined based on the detected photons.

Methods and computing apparatus for implementing a radiation dosimetry process. An example process may include exposing a first radiation sensitive film to a series of known doses of radiation, measuring a first set of radiation data with a measurement device, and determining a calibration curve. The calibration curve may be determined by selecting Raman spectral ranges based on the first set of radiation data, determining a plurality of band area ratios, and generating the calibration curve based on plotting the band areas and ratios compared to known dose. The radiation dosimetry process then exposes a second radiation sensitive film to an unknown dose of radiation, measures a second set of radiation data for the second radiation sensitive film with the measurement device, and determines a dose exposure level for the second radiation sensitive film by comparing the second set of radiation data with the calibration curve.

A method and an apparatus for determining information regarding the location of energy deposition of an ion beam, in particular a proton beam, in an absorptive medium, such as in the tissue of a patient undergoing radiation therapy.

The invention discloses a stereotactic radiotherapy plan evaluation method, device and equipment and a storage medium, and relates to the technical field of radiotherapy plan evaluation, and the method comprises the steps: obtaining the file data of a stereotactic radiotherapy plan; according to the file data, determining the division times and the division dose of the stereotactic radiotherapy plan; calculating according to the segmented dose to obtain dose basic parameters, target region parameters and organ-at-risk parameters of each time of division; and determining an evaluation result of the stereotactic radiotherapy plan according to the dose basic parameters, the target region parameters and the organ-at-risk parameters. Through full-automatic auxiliary structure generation, data extraction and dosimetry index calculation, evaluation of key parameters such as target area coverage and organ-endangering protection can be rapidly completed, manual intervention and personal errors are greatly reduced, and evaluation efficiency is remarkably improved.

The present embodiments relate generally to enabling an end user - e.g. medical physicists - to monitor radiation therapy and, with integration to the LINAC, adaptive radiotherapy. Embodiments record signals already released during radiotherapy, requiring no new irradiation of the patient for in vivo, in line, dose monitoring. Furthermore, as the transducers will be coupled to the patient with ultrasound gel, the present embodiments are not invasive to patients and will not introduce new discomfort during therapeutic procedures. The addition of the RiAD system provides the end user with additional information during the treatment of the patient, allowing for real-time beam tracking and dosimetry, enabling the end user to practice adaptive radiotherapy. The RiAD system enables the end user to ensure that proper dose delivery is occurring with each new beamlet and dose deposition, empowering them to adapt the medical treatment as it is performed and increase its precision in conventional electron beam radiotherapy, electron FLASH radiotherapy, and intraoperative electron beam radiotherapy.

An apparatus, system, and method for real-time dosimetry. An electron beam irradiation system includes one or more detectors. The detectors have coils that, when an electron travels by a sensor pad in the detector, the electron induces a current into the coils. The current is detected and the electron is counted. The number of electrons counted at the one or more detectors is compared to the number of electrons leaving an electron gun, giving a dosage of the workpiece being irradiated.

The invention relates to a radiotherapy oral mucosa reaction early warning and nursing system and a use method thereof, and belongs to the technical field of oral nursing. The system comprises a data acquisition module, a risk assessment module, an early warning prompt module and a nursing scheme generation module; the data acquisition module acquires electronic medical record data, radiotherapy plan data and radiomics characteristic data of a patient; the risk assessment module is based on data acquired by the data acquisition module. In the invention, by integrating electronic medical records, radiotherapy plan parameters and dose-specific radiomics characteristics, a multi-source data fusion prediction model is established, so that the limitation that a traditional method only depends on doctor experience and simple dosimetry parameters is overcome, and particularly, dose-specific mucous membrane subregions are generated through spatial Boolean operation; radiomics features capable of reflecting tissue heterogeneity of different dose regions are extracted, the accuracy and biological significance of a prediction model are remarkably improved, and early recognition of high-risk patients is achieved.

The invention discloses a quality control motif for heavy ion therapy and a testing method thereof, the quality control motif is a cube, and at least one edge of the cube is cut off; a rectangular inclined surface is arranged on the quality control die body at the position where the edge is cut off, and one short edge and the other opposite short edge of the rectangular inclined surface are respectively positioned on two opposite side surfaces of the quality control die body; and the distance from the rectangular inclined plane to the die body original point of the quality control die body is equal to the distance from the surface of the quality control die body, which takes the long side of the rectangular inclined plane as the common side, to the die body original point. According to the invention, dosimetry data of measurement beams of the quality control die body at 0 degree, 90 degrees and preset angles can be obtained only by placing the quality control die body once, so that a tester does not need to enter a test machine room for multiple times to replace the quality control die body in a test process, the number of times of exposing the quality control tester under induced radiation is reduced, and the exposure risk is reduced.

The present invention concerns dosimetry-related uses and methods that rely on a metastable technetium-99 (99mTc) radionuclide-comprising (dosimetric) radioimmunoconjugate (RIC) to evaluate or establish therapeutic doses of yttrium-90 (90Y) radionuclide-comprising (therapeutic) radioimmunoconjugates, both RICs targeting the same molecular target. More specifically, radioimmunoconjugates that comprise a CD66-binding component are used. Another aspect of the invention relates to Single Time Point dosimetry procedures replacing the need for traditionally used Multiple Time Point dosimetry procedures for yttrium-90 (90Y) radionuclide-comprising radioimmunoconjugates.

In some examples, a laser-based ophthalmological surgical system (hereinafter “system”) includes a therapeutic radiation source configured to emit therapeutic radiation with a first wavelength. The system may also include a probe radiation source configured to emit probe radiation with a second wavelength different than the first wavelength. The system may also include one or more optical elements configured to direct the therapeutic radiation and the probe radiation into an eye of a patient and to collect reflected probe radiation from the eye of the patient. The reflected probe radiation may be indicative of an amount of therapeutic radiation exposure of the eye of the patient. The system may also include a photodetector configured to receive the reflected probe radiation from the one or more optical elements and to generate a photocurrent indicative of the amount of therapeutic radiation exposure of the eye of the patient.

The invention discloses an in-vitro tissue thermal dose threshold determination method and system based on a thermochromic film, and belongs to the technical field of biomedicine ultrasonic dosimetry. The method comprises the following steps: preparing a thermochromic film with multiple color-changing temperature points, and calibrating a quantitative relationship between the hue and the temperature of the thermochromic film; constructing a sample formed by overlapping an in-vitro tissue, the thin film and a transparent phantom, and placing the sample in a focal region of a high-intensity focused ultrasound system; synchronously carrying out ultrasonic irradiation and film color-changing video acquisition; hue distribution of video frames is converted into temperature distribution through image processing, dynamic accumulation is carried out based on a thermal dose model, and a two-dimensional thermal dose distribution field is reconstructed; and finally, registering the thermal damage area after tissue irradiation with a thermal dose field, and extracting a thermal dose value on the outer side of the damage boundary to calculate a threshold value. The system comprises corresponding ultrasonic generation, sample bearing, image acquisition and control processing units. According to the invention, non-contact, real-time and two-dimensional visual measurement of the heat dose is realized, the system cost is low, and the heat dose threshold can be determined more objectively and accurately.

An apparatus, system, and method for real-time dosimetry. An electron beam irradiation system includes one or more detectors. The detectors have coils that, when an electron travels by a sensor pad in the detector, the electron induces a current into the coils. The current is detected, and the electron is counted. The number of electrons counted at the one or more detectors is compared to the number of electrons leaving an electron gun, giving a dosage of the workpiece being irradiated.

A system and method for determining accumulated radiation dose is presented. In some embodiments, the system and method include use of one or more RADFETs to measure and accumulated radiation dose over a desired period of time from an area of interest in a patient. In some embodiments, the one or more RADFETs may be arranged on a test strip, and electrical circuitry provided to selectively couple certain terminals of the RADFETS together to facilitate improved measurement of accumulated dose. A reader may also be utilized wherein the reader may receive a test strip, decouple the electrical connections between select terminals, inject a current into the RADFET and / or measure a voltage from the RADFET corresponding to an accumulated radiation dose.

This invention provides a hybrid manufacturing assembly of anatomical and workflow procedure in fabricating radiologically accurate animal phantoms. A method in which by utilizing additive manufacturing and molding technologies to fabricate the soft tissue, lungs, and hard tissue phantom of animal of interest and a way to assemble the organs such a radiologically heterogeneous phantom and structure is created and with the option to add provisions for radiological dosimetry devices is provided. The specified workflow is intended to address the need for low to medium volume production of small animal phantoms.

The invention provides a sample irradiation damage testing device and system under a hard XFEL condition, and relates to an intense light source experiment technology and radiation dosimetry. The device comprises a vacuum cavity, a posture adjusting mechanism, a dose testing mechanism, a sample table and a sample testing mechanism are arranged in an inner cavity of the vacuum cavity, the posture adjusting mechanism is used for clamping an attenuation slice, and the sample table is used for placing a sample; when an irradiation damage test is carried out, an XFEL light path is formed in the inner cavity of the vacuum cavity; and the attenuation sheet, the dose testing mechanism, the sample and the sample testing mechanism are sequentially located in a light path of the XFEL along the propagation direction of the XFEL. According to the invention, the irradiation dose of XFEL can be continuously, rapidly and accurately adjusted in a vacuum environment, and the tolerance limit of a sample can be given in real time.

The application discloses a matching method for realizing beam dosimetry equivalence between multiple treatment room units and related equipment, and belongs to the technical field of proton heavy ion radiotherapy. The method comprises the following steps: obtaining beam physical characteristic parameters of each treatment room unit under multiple mono-energetic beam conditions covering a clinical treatment energy region; defining a reference benchmark, taking the beam physical characteristic parameters of the reference benchmark as a target, and determining a matching parameter set for a to-be-matched treatment unit, so that the beam characteristics of the to-be-matched treatment unit are equivalent to the reference benchmark as a whole in a multi-dimensional characteristic space after adjustment; and the matching parameter set comprises physical additional module parameters and dose correction parameters. Through the hierarchical method of one-by-one matching of mono-energetic beams, multi-energy comprehensive iterative optimization, and unified matching parameter output, the method realizes dosimetry equivalent treatment between multiple treatment room units without the need of formulating a treatment plan again, improves the cross-device universality, treatment efficiency and safety of a multi-source multi-room proton radiotherapy system, and makes proton treatment available everywhere.

This article is a radiochromic film for an in-vivo dosimetry system used for radiotherapy and the like. The radiation dose is verified by scanning this article irradiated with radiation using a dedicated device.

The present invention relates to a real-time dosimetry device for neutron capture treatments. The device comprises a first module (1) to absorb a flow of dispersed neutrons in a patient which impinge on the device. The first module (1) is made of a lightweight material such as high-density polyethylene, graphite, or a molecular compound, with lithium content. A second module comprises a first segmented gamma radiation detector (2) that is sensitive to radiation interaction positions therein, and a second segmented gamma radiation detector (3), which is also sensitive to the positions, the second gamma radiation detector (3) being detachably coupled to the first gamma radiation detector (2). The device is particularly suitable for real-time dosage monitoring in patients during boron neutron capture treatments (BNCT).

A method for varying the radiation dosage in vivo during brachytherapy treatment is provided. The method includes infinitely varying the volume of radiation exposed to the patient. This volume variation feature is utilized as clinically indicated and can further reduce the risk of slippage of the device in situ.

Various devices, systems, and methods for performing personalized dosimetry of a patient receiving a radiopharmaceutical are described. In an example method, anatomic data is generated by performing a computed tomography (CT) scan on the patient when they are lying down and wearing a garment. Based on the anatomic data, locations of organs of the patient are determined with respect to one or more fiducial markers integrated with the garment. Detectors for detecting photons from a radiopharmaceutical are placed on the garment based on locations of the organs. Subsequently, the patient may be administered a dose of the radiopharmaceutical. When the patient wears the garment, the detectors may detect photons released from the decaying radiopharmaceutical that is distributed in the organs. The radiation dosage to the organs may be determined based on the detected photons.

The invention relates to a detector (1) for characterizing a dosimetry of radiation, comprising: an ionization detector (1IC) configured for characterizing a dosimetry of a radiation beam (5) propagating along a Z-axis, the ionization detector (1IC) comprising a matrix of ionization chambers (ICi) distributed over a plane (X, Y) perpendicular to the Z-axis, where the ionization detector (1IC) is located in the plane (X, Y); the ionization detector (1IC) has a first spatial resolution above the plane (X, Y), an additional detector (1A) distinct from the ionization detector (1IC) and whose second spatial resolution above the plane (X, Y) is higher than the first spatial resolution above the plane (X, Y) and is positioned in series with respect to the ionization detector (1IC) along the Z-axis, and a smart device (10), the smart device is configured to calculate a distribution of the calculated dose (Dij) from the dose (DICi) measured by the ionization detector (1IC) and the dose (DAij, DA0j) measured by the additional detector (1A).

This article is a radiochromic film for an in-vivo dosimetry system used for radiotherapy and the like. The radiation dose is verified by scanning this article irradiated with radiation using a dedicated device.

A computer-implemented method for radiotherapy contouring, the method comprising: receiving a dosimetric constraint for a physiological structure of a patient; determining a contour delineating and cl