33 results about "Dosimetry" patented technology

The invention relates to the technical field of tumor radiotherapy, and discloses a radiotherapy parameter intelligent recommendation method based on disease species, target area volume and dose characteristics, and the method comprises the steps: firstly obtaining historical helical tomography radiotherapy data containing different disease species and dose schemes, and carrying out the standardization; then, non-iterative forward dose calculation based on full-factor experimental design is executed, and treatment simulation plans are generated in batches; then, dosimetry and efficiency indexes are extracted, and an optimization rule base containing a response surface model and a Pareto optimal solution set is constructed; and finally, processing new case features by using a decision tree model, and outputting a recommended collimator mode, a screw pitch, a modulation factor value and an expected index range. According to the method, data, a model and a decision closed loop are constructed, so that the defects that the traditional plan design depends on artificial experience, the trial and error cost is high and multiple targets are difficult to balance are overcome, and the efficiency and the quality consistency of the radiotherapy plan design are remarkably improved.

Methods and computing apparatus for implementing a radiation dosimetry process. An example process may include exposing a first radiation sensitive film to a series of known doses of radiation, measuring a first set of radiation data with a measurement device, and determining a calibration curve. The calibration curve may be determined by selecting Raman spectral ranges based on the first set of radiation data, determining a plurality of band area ratios, and generating the calibration curve based on plotting the band areas and ratios compared to known dose. The radiation dosimetry process then exposes a second radiation sensitive film to an unknown dose of radiation, measures a second set of radiation data for the second radiation sensitive film with the measurement device, and determines a dose exposure level for the second radiation sensitive film by comparing the second set of radiation data with the calibration curve.

The invention relates to a radiotherapy oral mucosa reaction early warning and nursing system and a use method thereof, and belongs to the technical field of oral nursing. The system comprises a data acquisition module, a risk assessment module, an early warning prompt module and a nursing scheme generation module; the data acquisition module acquires electronic medical record data, radiotherapy plan data and radiomics characteristic data of a patient; the risk assessment module is based on data acquired by the data acquisition module. In the invention, by integrating electronic medical records, radiotherapy plan parameters and dose-specific radiomics characteristics, a multi-source data fusion prediction model is established, so that the limitation that a traditional method only depends on doctor experience and simple dosimetry parameters is overcome, and particularly, dose-specific mucous membrane subregions are generated through spatial Boolean operation; radiomics features capable of reflecting tissue heterogeneity of different dose regions are extracted, the accuracy and biological significance of a prediction model are remarkably improved, and early recognition of high-risk patients is achieved.

The present invention concerns dosimetry-related uses and methods that rely on a metastable technetium-99 (99mTc) radionuclide-comprising (dosimetric) radioimmunoconjugate (RIC) to evaluate or establish therapeutic doses of yttrium-90 (90Y) radionuclide-comprising (therapeutic) radioimmunoconjugates, both RICs targeting the same molecular target. More specifically, radioimmunoconjugates that comprise a CD66-binding component are used. Another aspect of the invention relates to Single Time Point dosimetry procedures replacing the need for traditionally used Multiple Time Point dosimetry procedures for yttrium-90 (90Y) radionuclide-comprising radioimmunoconjugates.

The invention discloses an in-vitro tissue thermal dose threshold determination method and system based on a thermochromic film, and belongs to the technical field of biomedicine ultrasonic dosimetry. The method comprises the following steps: preparing a thermochromic film with multiple color-changing temperature points, and calibrating a quantitative relationship between the hue and the temperature of the thermochromic film; constructing a sample formed by overlapping an in-vitro tissue, the thin film and a transparent phantom, and placing the sample in a focal region of a high-intensity focused ultrasound system; synchronously carrying out ultrasonic irradiation and film color-changing video acquisition; hue distribution of video frames is converted into temperature distribution through image processing, dynamic accumulation is carried out based on a thermal dose model, and a two-dimensional thermal dose distribution field is reconstructed; and finally, registering the thermal damage area after tissue irradiation with a thermal dose field, and extracting a thermal dose value on the outer side of the damage boundary to calculate a threshold value. The system comprises corresponding ultrasonic generation, sample bearing, image acquisition and control processing units. According to the invention, non-contact, real-time and two-dimensional visual measurement of the heat dose is realized, the system cost is low, and the heat dose threshold can be determined more objectively and accurately.

A system and method for determining accumulated radiation dose is presented. In some embodiments, the system and method include use of one or more RADFETs to measure and accumulated radiation dose over a desired period of time from an area of interest in a patient. In some embodiments, the one or more RADFETs may be arranged on a test strip, and electrical circuitry provided to selectively couple certain terminals of the RADFETS together to facilitate improved measurement of accumulated dose. A reader may also be utilized wherein the reader may receive a test strip, decouple the electrical connections between select terminals, inject a current into the RADFET and / or measure a voltage from the RADFET corresponding to an accumulated radiation dose.

This invention provides a hybrid manufacturing assembly of anatomical and workflow procedure in fabricating radiologically accurate animal phantoms. A method in which by utilizing additive manufacturing and molding technologies to fabricate the soft tissue, lungs, and hard tissue phantom of animal of interest and a way to assemble the organs such a radiologically heterogeneous phantom and structure is created and with the option to add provisions for radiological dosimetry devices is provided. The specified workflow is intended to address the need for low to medium volume production of small animal phantoms.

The application discloses a matching method for realizing beam dosimetry equivalence between multiple treatment room units and related equipment, and belongs to the technical field of proton heavy ion radiotherapy. The method comprises the following steps: obtaining beam physical characteristic parameters of each treatment room unit under multiple mono-energetic beam conditions covering a clinical treatment energy region; defining a reference benchmark, taking the beam physical characteristic parameters of the reference benchmark as a target, and determining a matching parameter set for a to-be-matched treatment unit, so that the beam characteristics of the to-be-matched treatment unit are equivalent to the reference benchmark as a whole in a multi-dimensional characteristic space after adjustment; and the matching parameter set comprises physical additional module parameters and dose correction parameters. Through the hierarchical method of one-by-one matching of mono-energetic beams, multi-energy comprehensive iterative optimization, and unified matching parameter output, the method realizes dosimetry equivalent treatment between multiple treatment room units without the need of formulating a treatment plan again, improves the cross-device universality, treatment efficiency and safety of a multi-source multi-room proton radiotherapy system, and makes proton treatment available everywhere.

A method for varying the radiation dosage in vivo during brachytherapy treatment is provided. The method includes infinitely varying the volume of radiation exposed to the patient. This volume variation feature is utilized as clinically indicated and can further reduce the risk of slippage of the device in situ.

Systems and methods for relative optimized linearization (ROL) for radiochromic film (RCF) dosimetry may eliminate the need for dose-response curve measurements while incorporating non-uniformity corrections. The ROL method may include, for each of multiple color channels, determining linearization parameters that minimize a cost function that evaluates an error between expected and calculated doses. The ROL method may use the linearization parameters to generate a variation map including dose-independent variation values and use the variation map to determine a corrected net optical density of the RCF. The ROL method may use the linearization parameters and the corrected net optical density to produce a dose image including corrected doses.

This invention discloses a matching method and related equipment for achieving beam dosimetric equivalence between multiple treatment chamber units, belonging to the field of proton and heavy ion radiotherapy technology. The method includes: acquiring beam physical characteristic parameters of each treatment chamber unit under multiple single-energy beam conditions covering the clinical treatment energy range; defining a reference benchmark; and determining a matching parameter set for the treatment unit to be matched, using the beam physical characteristic parameters of the reference benchmark as the target, so that its beam characteristics are adjusted to be overall equivalent to the reference benchmark in the multi-dimensional characteristic space; the matching parameter set includes physical additional module parameters and dose correction parameters. Through a hierarchical method of matching single-energy beams one by one, multi-energy comprehensive iterative optimization, and unified matching parameter output, dosimetrically equivalent treatment can be performed between multiple treatment chamber units without re-planning the treatment. This improves the cross-device versatility, treatment efficiency, and safety of multi-source multi-chamber proton radiotherapy systems, making proton therapy readily accessible.

The invention relates to a hybridization probe mixed solution for radiation biological dose detection as well as a preparation method and a product thereof, and belongs to the field of molecular cell genetics. The technical problem to be solved is to provide a hybridization probe mixed solution with significantly improved chromosome distortion recognition accuracy and sensitivity, higher detection efficiency and better repeatability. According to the key point of the technical scheme, the hybridization probe mixed solution is composed of a probe and a hybridization buffer solution, the volume ratio of the probe to the hybridization buffer solution is 1: (50-1000); the hybridization buffer solution is a 40%-70% formamide solution containing 10 to 20 mM of Tris-HCl or PBS (Phosphate Buffer Solution). When the hybridization probe mixed solution is used for radiation biological dose detection, the distortion identification accuracy and sensitivity are high, the radiation dose estimation precision is high, and the operation is convenient.

This present disclosure provides a multilayer dosimetry system, comprising: (a) a mounting layer, wherein the mounting layer is an optically clear polymer film having two sides coated with an optically clear first adhesive; (b) at least two active layers, wherein the mounting layer is sandwiched between active layers by affixing to the optically clear first adhesive; and (c) (i) an optically clear top base layer affixed to upper side of the sandwiched structure of (b), and (ii) a bottom base layer affixed to bottom side of the sandwiched structure of (b). The present disclosure also provides a point dose measurement device comprising a multilayer dosimetry system. The present disclosure further provides an integrated system to measure point dose radiation and a process for measuring point dose radiation.

A phantom system is disclosed that includes a phantom and at least one removable phantom attachment configured to be attached to the phantom so that the phantom system may have an orientation, location and / or anthropomorphic feature identifiable to an imaging device.

In a method to determine a patient (radiation) dose distribution (13), it is provided to calculate, from a measured signal (7) of a detector (6) placed behind a region of interest, a dose distribution (11) for a patient-shaped water equivalent phantom (12) and to compute from this a patient dose distribution (13) that takes into account inhomogeneities of a matter distribution of the patient (4).

A device and method is provided for measuring an electromagnetic dosimetric quantity received by an object illuminated by an electromagnetic field emitted by an electromagnetic source. The device including: a screen having a plurality unit cells and a top surface faced to the electromagnetic source and a bottom surface, the screen being adapted to absorb at least a portion of the electromagnetic field emitted by the electromagnetic source; a thermal sensor arranged relative to the bottom surface to measure a physical quantity relative to the heat distribution along a surface of the screen induced due to the absorption of the electromagnetic field in the screen medium; and a processing unit linked to the thermal sensor and configured to calculate the electromagnetic dosimetric quantities from the measured heat distribution, the information relative to the electromagnetic field emitted by the electromagnetic source, and the predetermined electromagnetic and thermal properties of the screen.

The invention discloses a three-dimensional scintillator dose measurement system based on a radiotherapy bed and a radiotherapy machine mounted camera, and the system comprises a cylindrical scintillator which is used as a die body and a detection medium, and is used for converting the three-dimensional dose distribution formed by a radiotherapy beam into three-dimensional scintillation light distribution; the radiotherapy bed is used for bearing the cylindrical scintillator; the bed end camera is used for acquiring an image of the scintillation light emitted from the bottom of the cylindrical scintillator; the rack camera group is mounted on a rack or a C-shaped arm of the radiotherapy machine and comprises a first side camera and a second side camera which are arranged opposite to each other; the processing unit is used for preprocessing the collected scintillation light image, executing three-dimensional reconstruction to obtain three-dimensional light intensity distribution, and converting the three-dimensional light intensity distribution into three-dimensional dose distribution based on a light intensity-dose calibration relation; and the comparison and evaluation unit is used for comparing the three-dimensional dose distribution with expected dose distribution of a treatment planning system (TPS) and outputting an evaluation index.

Disclosed is a computer-implemented method for providing a radiation treatment planning tool comprising providing input data comprising patient anatomy and / or geometry data and prescription data as input for an acceptability model; and providing, making use of the acceptability model, at least one of: a proposed radiation treatment plan, a predicted acceptability for a candidate radiation treatment plan and / or the proposed radiation treatment plan, a predicted probability that a radiation treatment plan meeting a predetermined acceptability threshold exists for the input data. The acceptability is yielded by the acceptability model and the output parameters of the radiation treatment plan comprise one or more dosimetric parameters and / or one or more treatment parameters.

The present embodiments relate generally to increasing the precision of radiotherapy by measuring the absolute dose delivered to the tumor and surrounding normal tissue during the treatment. More particularly, some embodiments relate to an imaging reconstruction system for X-ray-induced acoustic computed tomography (XACT) using a model-based reconstruction method. Instead of reconstructing relative dose information for radiation beam localization, the system is capable of reconstructing absolute in vivo dose information. The XACT absolute in vivo dosimetry tool holds great potential for personalized cancer treatment and better outcomes. In some embodiments, thermal parameters, such as Gruneisen parameters, are used to convert reconstructed pressure information to dose. In addition, to avoid problems caused by electrical system gain, calibration tools, such as ion chambers, can be used to calibrate the system.

The present disclosure is for a dosimetry device which produces immediate readings of radiation levels that are easily discernible, do not require electronic components (e.g., digital readouts, batteries, etc.), and are not subjective. Instead of requiring such components or deciphering a change in color, the dosimetry device of the present disclosure identifies radiation exposure through an identifier that changes from an apparently colorless (i.e., clear, blank, non-existent) visual identifier to a visibly present identifier (as compared to a change in color) or via a change relative to a masking substrate or background.

The invention discloses a matching method and related equipment for realizing beam dosimetry equivalence among multiple treatment room units, and belongs to the technical field of proton heavy ion radiotherapy, and the method comprises the steps: obtaining beam physical characteristic parameters of each treatment room unit under a plurality of single-energy beam conditions covering a clinical treatment energy region; defining a reference datum, and determining a matching parameter set for a to-be-matched treatment unit by taking beam physical characteristic parameters of the reference datum as targets, so that the beam characteristics of the to-be-matched treatment unit are integrally equivalent to the reference datum in the multi-dimensional characteristic space after being adjusted; the matching parameter set includes a physical additional module parameter and a dose correction parameter. Through a layering method of single-energy beam one-by-one matching, multi-energy comprehensive iterative optimization and unified matching parameter output, dosimetry equivalent treatment is carried out among a plurality of treatment room units without reformulating a treatment plan, the cross-device universality, treatment efficiency and safety of the multi-source multi-room proton radiotherapy system are improved, and the system is suitable for popularization and application. And the proton treatment is accessible.

The application relates to the technical field of radiation measurement, in particular to an ionizing radiation dose measurement method and system based on a pulse signal. The method comprises the following steps: acquiring a pulse signal precision performance parameter of an ionizing radiation dose measurement parameter; acquiring a parameter control influence degree of the ionizing radiation dose measurement parameter according to the pulse signal precision performance parameter; acquiring metrological accuracy of a radiation dose measurement result according to the parameter control influence degree; and performing different processing on the radiation dose measurement result according to the metrological accuracy. According to the application, the pulse signal precision performance parameter of the ionizing radiation dose measurement parameter and the parameter control influence degree of the radiation dose measurement parameter are analyzed, the metrological accuracy of the radiation dose measurement result is obtained, and different processing is performed on the radiation dose measurement result according to the metrological accuracy, so that the accuracy of the ionizing radiation measurement result based on the pulse signal is improved.

This invention provides a method, apparatus, and electronic device for determining radiotherapy plans based on nanodosimetry, relating to the field of radiation technology. The method for determining radiotherapy plans based on nanodosimetry includes: obtaining time-varying distribution data of nanodosimetry within a mixed heavy ion beam radiation field using a simulation platform; wherein the mixed heavy ion beam radiation field corresponds to a candidate radiotherapy plan at an ultra-high dose rate for the target patient; the ultra-high dose rate is a dose rate greater than a target threshold; based on the time-varying distribution data of nanodosimetry, obtaining a dose correction factor corresponding to the candidate radiotherapy plan using a cell survival fraction model; and adjusting the candidate radiotherapy plan according to the dose correction factor to obtain the target radiotherapy plan for the target patient. This invention can establish an accurate and reliable biophysical model of a heavy ion ultra-high dose rate radiation field, enabling the determination of precise radiotherapy plans based on this biophysical model.

In an approach to real time monitoring of exposure atmosphere in an aerosol exposure system, a system includes one or more aerosol inputs; a mixing bulb; a dilution manifold with a plurality of dosimetry positions; a multiport valve; and a real-time aerosol monitor (RAM). The system is configured to: receive aerosol samples from the one or more aerosol inputs; mix the aerosol samples with humidified air using the mixing bulb; input the humidified aerosol samples into the dilution manifold; for each dosimetry position of the plurality of dosimetry positions: measure an exposure concentration for the humidified aerosol sample from the dosimetry position of the dilution manifold using the RAM; and select a next dosimetry position of the dilution manifold.

The utility model relates to stereotactic radiotherapy equipment for realizing dose tracking, which belongs to the technical field of radiotherapy equipment, and comprises a connecting piece, a dose detection assembly, an accelerator assembly and a folding telescopic mechanism, the interference caused by oblique incidence of the beam and the influence of inaccurate dosage are avoided; the dose detection assembly can follow a beam to carry out full spherical irradiation in real time through the semi-annular structure, in addition, when the dose detection assembly does not need to work or a quality control test is carried out, the dose detection assembly is automatically retracted to an initial position through the folding telescopic mechanism, on one hand, the effect of protecting the dose detection assembly is achieved, and on the other hand, the space is saved; the arrangement of the treatment bed is facilitated, the quality control test is not influenced, and the technical problem that the stereotactic radiotherapy equipment connected with the mechanical arm structure cannot acquire the dosimetry information in the radiotherapy process in real time is solved.

This invention discloses a method and system for optimizing the dosimetric performance of an intelligent adaptive collimator, belonging to the field of tumor radiotherapy technology. The method includes: generating multiple collimator end-face schemes, each represented by a set of blade positions; conducting dosimetric experiments on each scheme to obtain measured penumbra values, forming a training dataset; training an artificial intelligence network model using the training dataset to obtain a dosimetric intelligent prediction network model; inputting the target collimator end-face scheme into the prediction model to obtain predicted penumbra values; and using an optimization algorithm to iteratively optimize the target collimator end-face scheme based on the predicted penumbra values ​​to generate an optimized collimator end-face scheme. This invention significantly shortens the collimator end-face optimization cycle, reduces optimization costs, and improves optimization efficiency by combining flexible collimator structure shaping with a combination of measured data, artificial intelligence prediction, and optimization algorithms.