330results about "Particle separator tubes" patented technology

Methods and systems are disclosed for predictive classification of a raw mass spectrum of a sample, the spectrum resulting from mass spectrometry analysis. The predictive classification is performed by a trained large-scale spectral model, including a self-supervised large-scale base spectral model trained with unidentified sample spectra from a plurality of sources and fine-tuned with a task-specific model trained with identified spectra.

A method of performing liquid chromatography (LC) with an LC system including an LC column and an analyzer includes delivering a transport liquid to an open port interface (OPI) of a sample receiving circuit, wherein the sample receiving circuit includes a sample transfer chamber. A sample is ejected from a sample holder into the OPI with a non-contact ejector. The transport liquid and the sample are received in the sample transfer chamber. The sample transfer chamber is decoupled from the sample receiving circuit. A solvent is delivered to the analysis circuit. The sample is pushed from the sample transfer chamber with the solvent. The sample and the solvent is passed through the LC column to produce an eluent. The eluent is analyzed with the analyzer.

An example method performed via a computing device for providing support for a mass spectrometry (MS) system includes obtaining from a mass spectrometry library (i) a ranked hit list of reference spectra corresponding to a set of fragmented spectra of an analyte acquired with the MS system; and (ii) a first set of metadata corresponding to the list of sorted hit items for the reference spectrum. The method also includes obtaining, from the MS system, a second set of metadata corresponding to the set of fragmented spectra. The method further includes evaluating an order of entries in the ranked hit item list with a machine learning model based on the first set of metadata and the second set of metadata.

A method for collaborative source apportionment of volatile organic compounds (VOCs), a product, a medium, and a device are provided. The method includes: establishing a single particle classification model; training and optimizing the single particle classification model with a local pollution library, and analyzing pollution sources of single particle mass spectrometric data to be apportioned to obtain a time series of the pollution sources contributing to the particulate matter (PM); obtaining VOCs factors of the pollution sources and a time series thereof; performing correlation calculation on the time series of the pollution sources contributing to the PM and the time series of the VOCs factors to obtain a correlation coefficient; and attributing the PM and the VOCs factor having the correlation coefficient higher than a set threshold to a same pollution source, and identifying a common pollution source of the PM and the VOCs.

A method of determining a confidence measure of precursor inference in mass spectrum data. The method includes evaluating the response profile using response profile metrics and reporting the confidence measure of the precursor inference using the response profile and the evaluating of the response profile. Also a method of detecting conflicting relationships between precursors including filtering an intensity at at least one position across the scanning ion transmission window dimension. Another method a method of detecting conflicting relationships between precursors includes generating, based on an encoding, a trace of the scanning ion transmission window dimension wherein each sum is substituted with a binary metric for presence of the at least one unique product ion in each window. Further a method of identifying a precursor m / z including determining an intercept between the rising linear function and the falling linear function, and identifying the precursor m / z using the intercept.

Aspects of the present disclosure relate generally to systems and methods for use in the implementation and / or operation of quantum information processing (QIP) systems, and more particularly, to a technique for the fabrication of laser-ablation targets used in atomic sources for QIP systems that are based on atomic-based qubits.

Systems and methods are provided for predicting the mass spectrum of an unknown compound. An experimental mass spectrum of a known compound is obtained. One or more mass peaks of the experimental mass spectrum corresponding to a substructure of the known compound are annotated with at least one modification an unknown compound is predicted to include. An in-silico mass spectrum is created for the unknown compound from the experimental mass spectrum and the annotated one or more mass peaks. The unknown compound is then identified from a sample by mass analyzing the sample, producing an unknown experimental mass spectrum, and comparing the unknown experimental mass spectrum to the in-silico mass spectrum.

This invention relates to a method for detecting the activity of a toxin produced by bacteria of the families Peptostreptococcaceae or Clostridiaceae using mass spectrometry, which comprises the following steps: a) providing a planar surface suitable for mass spectrometry measurement, with attached affinity molecules; b) incubating the planar surface from step a) with the substrate of the toxin to be detected, to bind the substrate to the affinity molecules; c) subsequently incubating the planar surface from step b) with a sample in which the active toxin is to be detected, in the presence of a modification compound, and incubating it for a time sufficient for the substrate to react with the modification compound in the presence of the active toxin, if present in the sample, to form a modified substrate if the active toxin is present in the sample; d) removing the remnants of the sample; e) subjecting the (modified) substrate on the planar surface to matrix-assisted laser desorption / ionization, ionizing it and subsequently measuring the mass spectrum of the (modified) substrate; f) analyzing the measured mass spectrum, such that if the measured mass spectrum corresponds to the non-modified substrate, the active toxin is not present, and if the measured mass spectrum corresponds to the modified substrate or a mixture of the modified and non-modified substrate, then the active toxin is present in the sample. The invention further relates to a device for the soft landing of affinity molecule ions onto a planar surface suitable for mass spectrometry for carrying out step a) of the above method.

The utility model relates to the technical field of waste gas emission devices, and discloses a waste gas emission device which comprises a waste gas emission assembly. According to the waste gas emission device and the liquid chromatography tandem mass spectrometer, a plurality of gas inlet pipes and an exhaust main pipe are integrated through the treatment box, multi-channel waste gas centralized treatment is achieved, the servo motor drives the reciprocating lead screw to drive the cleaning brush to reciprocate along the guide rod, a filter screen made of a stainless steel sintered mesh material is automatically cleaned, blockage is avoided, and the working efficiency is improved. The fan assembly accelerates waste gas flowing through a gas collecting hood, a rotating shaft of the fan assembly is in linkage with a first chain wheel, a second chain wheel and a chain through a first bevel gear, a transmission rod and a second bevel gear, the cleaning system can drive the auxiliary exhaust function to work, extra energy consumption is not needed, and the device is more practical; a waste gas pipe on the liquid chromatogram tandem mass spectrometer body is communicated with a gas inlet pipe on one side of the treatment box through a second one-way valve and a second electromagnetic valve, so that directional conveying of waste gas is ensured, and the scheme realizes a self-cleaning effect through mechanical linkage.

A method for assessing a molecular or isotopic composition of a fluid includes analyzing a proportion of the fluid derived from a source to determine the source of the fluid, quantifying the proportion of the fluid derived from one or more sources, and assessing the relationships of chemical species within the fluid to validate the source of the fluid. This assessment can be accomplished through the direct measurement of molecular composition of fluid mixtures or the isotopic composition of specific fluids in that mixture, and / or a combination of statistical, thermodynamics, or kinetic modelling of these chemical reactions. The results of these measurements and models can be used to verify the source and conditions of various forms of hydrogen or other resources.

The application discloses a kind of artificial cells for single-cell mass spectrometry and preparation method thereof, wherein artificial cell includes internal water phase, intermediate oil phase and external water phase;Internal water phase includes polyethylene glycol and polyvinyl alcohol aqueous solution, intermediate oil phase includes L-alpha-phosphatidylcholine chloroform and hexane mixture;External water phase includes PVA and F-68 aqueous solution.Compared with natural cell sample, the novel artificial single cell based on microfluidic self-assembly developed in the application has better uniformity, stability and controllability, effectively avoids significant measurement difference between single-cell individual samples, and effectively solves the problem of difficult stable preservation of biological samples.The proposed artificial cell preparation method will largely solve the problem of lack of standard reference material in the field of single-cell mass spectrometry, making the results of single-cell mass spectrometry method more accurate, reliable and mutually recognized.

A method for analyzing a sample using an electron microscope includes: generating ions, molecules, or other particles, such as droplets, from a target sample; introducing the ions, molecules, or other particles into a vacuum cavity of a transmission electron microscope (TEM) in a direction intersecting the path of a pulsed electron beam; recording an electron diffraction pattern associated with the ions through which the pulse passes at each pulse of the electron beam; and calculating the three-dimensional (3D) structure of the ion species based on the recorded electron diffraction pattern.

The method for non-targeted mass spectrometric identification of tobacco carbonyl components includes the steps of: (1) preparing a tobacco sample extract; (2) derivatizing the extract with 2,4-dinitrophenylhydrazine (DNPH) to obtain a first tobacco sample; (3) derivatizing the extract with DNPH-d3 instead of DNPH to obtain a second tobacco sample; (4) preparing a mixed tobacco sample; (5) preparing a blank sample; (6) performing UPLC-Orbitrap-HRMS analysis on each of the first tobacco sample, the second tobacco sample, the mixed tobacco sample, and the blank sample to obtain LC-MS raw data; (7) processing the LC-MS raw data to obtain raw mass spectrometry characteristic data; (8) performing multistage filtering on the raw mass spectrometry characteristic data; and (9) performing structural annotation or identification on the finally retained chromatographic peaks to obtain tobacco carbonyl components. By performing multi-stage filtering on the mass spectrometry profile data, the chromatographic-mass spectrometry information of noise or interference components in the raw data set can be rapidly removed to obtain compositional information of aldehyde and ketone chemical components in cigarettes.

Disclosed are methods and systems that can detect, monitor, adjust, and optimize fluid dynamic conditions within a sampling system comprising a transport capillary (e.g., an open port interface). The methods and systems detect an acoustic signal within the sampling system and, based on characteristics of the detected acoustic signal, adjust flow rate conditions of the liquid and / or airflow in the sampling system. Also provided are automated control and feedback systems (e.g., automated feedback adjustments made to an inlet pump flow rate, nebulizer gas flow rate, or both) that adjust, tune, and maintain flow conditions within a transport line based on a detected acoustic signal.

An ion repulsive surface, comprises: a first plurality of elongated electrodes distributed along an axis, configured to receive a first RF voltage with an asymmetric waveform; and a second plurality o

An abnormal site identification method according to the present disclosure is an abnormal site identification method for a triple quadrupole mass spectrometer comprising a first quadrupole and a second quadrupole on opposite sides of a collision cell. The abnormal site identification method includes: a step (S20) of acquiring comparison data; a step (S30) of acquiring reference data; a step (S50) of identifying an abnormal site in the triple quadrupole mass spectrometer on the basis of the reference data and the comparison data; and a step (S60) of reporting the abnormal site.

Systems and methods for analyzing fluid samples containing nanoparticles for the determination of nanoparticle count and nanoparticle elemental composition are described. In an aspect, a system embodiment includes, but is not limited to, a remote sampling system configured to receive a fluid sample containing nanoparticles, the remote sampling system including a particle counter configured to determine a number of nanoparticles present in the fluid sample via light scattering detection; a sample analysis system configured to receive the fluid sample from the remote sampling system, the sample analysis system including a mass spectrometer configured to determine an elemental composition of the nanoparticles present in the fluid sample; and a system controller communicatively configured to provide a distribution of the nanoparticles in the fluid sample by specific element type based on an output from each of the mass spectrometer and the particle counter.

A method of analysing a structure of a composition of matter in a sample comprising obtaining a data set comprising a plurality of spectra from the composition, from a first method of analysis dividing each of the spectra into a plurality of bins determining a control parameter or parameters indicative of synchronised fluctuations in signal intensity across some or all channels, resulting in universal correlation between said bins determining a partial covariance of different bins across the plurality of spectra using the control parameter to correct the correlation of intensity fluctuations between said bins.

Provided is a sample pretreatment device that enables efficient dispensing of a sample solution when multiple sample solutions are used. One embodiment of the present invention includes: a container storage section that can store multiple containers including a first well plate and a second well plate, the first well plate being formed by forming wells in an N row by M column matrix, and the second well plate being formed with N elongated wells having a length corresponding to the M wells in one row of the first well plate, or being formed with M elongated wells having a length corresponding to the N wells in one column of the first well plate; a dispensing section including a worktable on which the containers can be placed, a pipette section including M aligned pipette tips corresponding to the M wells in one row of the first well plate or N aligned pipette tips corresponding to the N wells in one column of the first well plate, and a pump section that aspirates and ejects a liquid in the container placed on the worktable via the pipette section; a conveyance section that conveys the containers between the container storage section and the worktable; and a control section that controls the operation of the dispensing section and the conveyance section.

Disclosed are a battery (100), an electronic device and a polarity leading-out method. The battery (100) comprises a casing (10) and an electrode assembly (20) accommodated in the casing (10), the inner surface of the casing (10) being provided with a first welding area (132), and the first welding area (132) being used for being welded and connected to the electrode assembly (20). The first welding area (132) comprises a negative ion organic peak 118, the ion count ratio of the negative ion organic peak 118 being A1%, and A1≤0.5. The casing (10) can be welded to the electrode assembly (20) by means of the first welding area (132), so as to lead out a positive electrode or a negative electrode of the electrode assembly (20). The degree of impurities contained in the first welding area (132) can be defined by the content of an antirust agent component. The first welding area (132) is obtained by performing cleaning on the casing (10), and, during cleaning, the main component obtained after thermal cracking of the antirust agent is triethanolamine, which is corresponding to the organic peak 118. Since the ion count ratio of the negative ion organic peak 118 of the first welding area (132) is A1%, and A1≤0.5, the impurity content is significantly reduced; when the casing (10) and the electrode assembly (20) are welded, explosion point formation can be effectively reduced, thereby reducing the risk of liquid leakage of the battery (100), and improving the safety performance of the battery (100).

A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

The present disclosure provides a tube and an analysis system that are capable of analyzing an analysis target gas discharged from a thermal analysis device or the like with accuracy. A tube (transfer tube 23) according to the present disclosure is a tube for supplying an analysis target gas discharged from a thermal analysis device 10, a heating furnace, or a heating furnace-type pyrolyzer to a gas analysis unit 80, and the tube includes an outer cylinder portion 23a formed of metal and an inner cylinder portion 23b formed of fluororesin, the inner cylinder portion 23b being arranged inside the outer cylinder portion 23a in the radial direction.

An electron capture dissociation apparatus. The apparatus comprises a linear ion trap (3) consisting of an even number of strip electrodes (3.1), wherein an in-phase radio frequency voltage and an anti-phase radio frequency voltage are alternately applied to the strip electrodes (3.1) of the linear ion trap (3) in sequence, such that there is a saddle point potential at the central axis of an ion trapping space; and electrons emitted by an electron emission source (1) are accelerated by means of an accelerating electrode (2.1), are then focused by means of a focusing lens (2.2), and then enter the ion trapping space (3.2) through an electron introduction slot (3.3). The potential of the electron emission source (1) is set to change relative to the saddle point potential within a radio frequency cycle according to a predefined pattern, such that electrons enter the linear ion trap (3) through the electron introduction slot (3.3) when the radio frequency voltages on the strip electrodes (3.1) where the electron introduction slot (3.3) is located are in a positive half-cycle, and decelerate, before reaching the central axis of the ion trapping space (3.2), to an energy range where electron capture dissociation may occur, thereby improving the time window and dissociation efficiency of electron capture dissociation.

Aspects of the present disclosure relate generally to systems and methods for use in the implementation and / or operation of quantum information processing (QIP) systems, and more particularly, to a technique for the fabrication of laser-ablation targets used in atomic sources for QIP systems that are based on atomic-based qubits.

Aspects of the present disclosure relate generally to systems and methods for use in the implementation and / or operation of quantum information processing (QIP) systems, and more particularly, to a technique for the fabrication of laser-ablation targets used in atomic sources for QIP systems that are based on atomic-based qubits.

Embodiments disclosed herein include a processing tool for measuring neutral radical concentrations. In an embodiment, the processing tool comprises a processing chamber, and a neutral radical mass spectrometry (NRMS) analyzer fluidically coupled to the processing chamber. In an embodiment, the NRMS analyzer comprises a first chamber fluidically coupled to the processing chamber, where the first chamber comprises a modulator, and a second chamber fluidically coupled to the first chamber, where the second chamber is a residual gas analyzer or a mass spectrometer. In an embodiment, an unobstructed line of sight passes from the processing chamber to the second chamber.