198results about "Particle separator tubes" patented technology

Methods and systems are disclosed for predictive classification of a raw mass spectrum of a sample, the spectrum resulting from mass spectrometry analysis. The predictive classification is performed by a trained large-scale spectral model, including a self-supervised large-scale base spectral model trained with unidentified sample spectra from a plurality of sources and fine-tuned with a task-specific model trained with identified spectra.

A method of performing liquid chromatography (LC) with an LC system including an LC column and an analyzer includes delivering a transport liquid to an open port interface (OPI) of a sample receiving circuit, wherein the sample receiving circuit includes a sample transfer chamber. A sample is ejected from a sample holder into the OPI with a non-contact ejector. The transport liquid and the sample are received in the sample transfer chamber. The sample transfer chamber is decoupled from the sample receiving circuit. A solvent is delivered to the analysis circuit. The sample is pushed from the sample transfer chamber with the solvent. The sample and the solvent is passed through the LC column to produce an eluent. The eluent is analyzed with the analyzer.

An example method performed via a computing device for providing support for a mass spectrometry (MS) system includes obtaining from a mass spectrometry library (i) a ranked hit list of reference spectra corresponding to a set of fragmented spectra of an analyte acquired with the MS system; and (ii) a first set of metadata corresponding to the list of sorted hit items for the reference spectrum. The method also includes obtaining, from the MS system, a second set of metadata corresponding to the set of fragmented spectra. The method further includes evaluating an order of entries in the ranked hit item list with a machine learning model based on the first set of metadata and the second set of metadata.

A method of determining a confidence measure of precursor inference in mass spectrum data. The method includes evaluating the response profile using response profile metrics and reporting the confidence measure of the precursor inference using the response profile and the evaluating of the response profile. Also a method of detecting conflicting relationships between precursors including filtering an intensity at at least one position across the scanning ion transmission window dimension. Another method a method of detecting conflicting relationships between precursors includes generating, based on an encoding, a trace of the scanning ion transmission window dimension wherein each sum is substituted with a binary metric for presence of the at least one unique product ion in each window. Further a method of identifying a precursor m / z including determining an intercept between the rising linear function and the falling linear function, and identifying the precursor m / z using the intercept.

Systems and methods are provided for predicting the mass spectrum of an unknown compound. An experimental mass spectrum of a known compound is obtained. One or more mass peaks of the experimental mass spectrum corresponding to a substructure of the known compound are annotated with at least one modification an unknown compound is predicted to include. An in-silico mass spectrum is created for the unknown compound from the experimental mass spectrum and the annotated one or more mass peaks. The unknown compound is then identified from a sample by mass analyzing the sample, producing an unknown experimental mass spectrum, and comparing the unknown experimental mass spectrum to the in-silico mass spectrum.

The utility model relates to the technical field of waste gas emission devices, and discloses a waste gas emission device which comprises a waste gas emission assembly. According to the waste gas emission device and the liquid chromatography tandem mass spectrometer, a plurality of gas inlet pipes and an exhaust main pipe are integrated through the treatment box, multi-channel waste gas centralized treatment is achieved, the servo motor drives the reciprocating lead screw to drive the cleaning brush to reciprocate along the guide rod, a filter screen made of a stainless steel sintered mesh material is automatically cleaned, blockage is avoided, and the working efficiency is improved. The fan assembly accelerates waste gas flowing through a gas collecting hood, a rotating shaft of the fan assembly is in linkage with a first chain wheel, a second chain wheel and a chain through a first bevel gear, a transmission rod and a second bevel gear, the cleaning system can drive the auxiliary exhaust function to work, extra energy consumption is not needed, and the device is more practical; a waste gas pipe on the liquid chromatogram tandem mass spectrometer body is communicated with a gas inlet pipe on one side of the treatment box through a second one-way valve and a second electromagnetic valve, so that directional conveying of waste gas is ensured, and the scheme realizes a self-cleaning effect through mechanical linkage.

A method for assessing a molecular or isotopic composition of a fluid includes analyzing a proportion of the fluid derived from a source to determine the source of the fluid, quantifying the proportion of the fluid derived from one or more sources, and assessing the relationships of chemical species within the fluid to validate the source of the fluid. This assessment can be accomplished through the direct measurement of molecular composition of fluid mixtures or the isotopic composition of specific fluids in that mixture, and / or a combination of statistical, thermodynamics, or kinetic modelling of these chemical reactions. The results of these measurements and models can be used to verify the source and conditions of various forms of hydrogen or other resources.

The application discloses a kind of artificial cells for single-cell mass spectrometry and preparation method thereof, wherein artificial cell includes internal water phase, intermediate oil phase and external water phase;Internal water phase includes polyethylene glycol and polyvinyl alcohol aqueous solution, intermediate oil phase includes L-alpha-phosphatidylcholine chloroform and hexane mixture;External water phase includes PVA and F-68 aqueous solution.Compared with natural cell sample, the novel artificial single cell based on microfluidic self-assembly developed in the application has better uniformity, stability and controllability, effectively avoids significant measurement difference between single-cell individual samples, and effectively solves the problem of difficult stable preservation of biological samples.The proposed artificial cell preparation method will largely solve the problem of lack of standard reference material in the field of single-cell mass spectrometry, making the results of single-cell mass spectrometry method more accurate, reliable and mutually recognized.

A method for analyzing a sample using an electron microscope includes: generating ions, molecules, or other particles, such as droplets, from a target sample; introducing the ions, molecules, or other particles into a vacuum cavity of a transmission electron microscope (TEM) in a direction intersecting the path of a pulsed electron beam; recording an electron diffraction pattern associated with the ions through which the pulse passes at each pulse of the electron beam; and calculating the three-dimensional (3D) structure of the ion species based on the recorded electron diffraction pattern.

Disclosed are methods and systems that can detect, monitor, adjust, and optimize fluid dynamic conditions within a sampling system comprising a transport capillary (e.g., an open port interface). The methods and systems detect an acoustic signal within the sampling system and, based on characteristics of the detected acoustic signal, adjust flow rate conditions of the liquid and / or airflow in the sampling system. Also provided are automated control and feedback systems (e.g., automated feedback adjustments made to an inlet pump flow rate, nebulizer gas flow rate, or both) that adjust, tune, and maintain flow conditions within a transport line based on a detected acoustic signal.

An ion repulsive surface, comprises: a first plurality of elongated electrodes distributed along an axis, configured to receive a first RF voltage with an asymmetric waveform; and a second plurality o

Systems and methods for analyzing fluid samples containing nanoparticles for the determination of nanoparticle count and nanoparticle elemental composition are described. In an aspect, a system embodiment includes, but is not limited to, a remote sampling system configured to receive a fluid sample containing nanoparticles, the remote sampling system including a particle counter configured to determine a number of nanoparticles present in the fluid sample via light scattering detection; a sample analysis system configured to receive the fluid sample from the remote sampling system, the sample analysis system including a mass spectrometer configured to determine an elemental composition of the nanoparticles present in the fluid sample; and a system controller communicatively configured to provide a distribution of the nanoparticles in the fluid sample by specific element type based on an output from each of the mass spectrometer and the particle counter.

A method of analysing a structure of a composition of matter in a sample comprising obtaining a data set comprising a plurality of spectra from the composition, from a first method of analysis dividing each of the spectra into a plurality of bins determining a control parameter or parameters indicative of synchronised fluctuations in signal intensity across some or all channels, resulting in universal correlation between said bins determining a partial covariance of different bins across the plurality of spectra using the control parameter to correct the correlation of intensity fluctuations between said bins.

Disclosed are a battery (100), an electronic device and a polarity leading-out method. The battery (100) comprises a casing (10) and an electrode assembly (20) accommodated in the casing (10), the inner surface of the casing (10) being provided with a first welding area (132), and the first welding area (132) being used for being welded and connected to the electrode assembly (20). The first welding area (132) comprises a negative ion organic peak 118, the ion count ratio of the negative ion organic peak 118 being A1%, and A1≤0.5. The casing (10) can be welded to the electrode assembly (20) by means of the first welding area (132), so as to lead out a positive electrode or a negative electrode of the electrode assembly (20). The degree of impurities contained in the first welding area (132) can be defined by the content of an antirust agent component. The first welding area (132) is obtained by performing cleaning on the casing (10), and, during cleaning, the main component obtained after thermal cracking of the antirust agent is triethanolamine, which is corresponding to the organic peak 118. Since the ion count ratio of the negative ion organic peak 118 of the first welding area (132) is A1%, and A1≤0.5, the impurity content is significantly reduced; when the casing (10) and the electrode assembly (20) are welded, explosion point formation can be effectively reduced, thereby reducing the risk of liquid leakage of the battery (100), and improving the safety performance of the battery (100).

A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

Aspects of the present disclosure relate generally to systems and methods for use in the implementation and / or operation of quantum information processing (QIP) systems, and more particularly, to a technique for the fabrication of laser-ablation targets used in atomic sources for QIP systems that are based on atomic-based qubits.

This disclosure provides methods, systems, and compositions of matter for studying solvent accessibility and three-dimensional structure of biological molecules. A plasma can be used to generate marker radicals, which can interact with a biological molecule and mark the solvent-accessible portions of the biological molecule.

The application teaches a method for forming shaped capillary emitters. The method comprises directing a laser to a capillary through a beam restrictor device. The method comprises rastering the laser along a direction parallel to a flow direction in the capillary to heat the capillary. The method comprises applying tensile force at a first end and a second end of the capillary to cause the capillary to break and form two shaped capillary emitter tips.

To provide a chamber and system for decomposing and scanning a surface of a semiconductor wafer.SOLUTION: Systems and methods are disclosed for integrated decomposition and scanning of a semiconductor wafer. A single chamber is utilized to decompose and scan a target wafer.SELECTED DRAWING: Figure 1A

An example method performed via a computing device for providing support to a mass spectrometry (MS) system includes obtaining from a mass spectral library (i) an ordered hitlist of reference spectra corresponding to a set of fragmentation spectra of an analyte acquired with the MS system; and (ii) a first set of metadata corresponding to the ordered hitlist of reference spectra. The method also includes obtaining from the MS system a second set of metadata corresponding to the set of fragmentation spectra. The method also includes evaluating an order of entries in the ordered hitlist with a machine learning model based on the first set of metadata and the second set of metadata.

A nucleic acid structural analysis method includes: an HAD-MSn analysis step (101) of introducing a hydrogen radical into a space in which an ion derived from a test nucleic acid is present to perform dissociation of the ion, and performing mass spectrometry on a plurality of fragment ions generated by the dissociation to collect m / z information on the plurality of fragment ions; and a structure estimation step (103) of estimating a structure of the test nucleic acid on a basis of the m / z information on the plurality of fragment ions obtained in the HAD-MSn analysis step. This makes it possible to deal with precursor ions having various charges, and makes it easier to perform the structure estimation of the nucleic acid based on the mass spectrum.

Methods and compositions for detecting isoaspartate residues in polypeptides using mass spectrometry, and for distinguishing isoaspartate residues from aspartate and / or asparagine residues in a polypeptide using MS analysis. Polypeptides containing one or more isoaspartate residues, or suspected of containing one or more isoaspartate residues, are treated with L-isoaspartyl methyltransferase (PIMT), which is able to selectively modify isoaspartate and impart a mass change to the amino acid residue. The polypeptide is then analysed using mass spectrometry, where a mass change caused by the PIMT reaction is detected and characterized. Preferably, these methods are able to be performed without the use of liquid chromatography or other similar separation techniques prior to mass spectrometry analysis.

A first trend chart (170) and a second trend chart (172) are displayed along with a chromatogram (168). The first trend chart (170) is generated based on a plurality of first representative value arrays obtained from a plurality of mass spectra. The second trend chart (172) is generated based on a plurality of second representative value arrays obtained from the plurality of mass spectra. A mass spectrum stable period is determined based on the first trend chart (170) and the second trend chart (172).

A method of small molecule biochemical profiling of an individual subject for diagnosis of a disease or disorder, a method for facilitating diagnosis of a disease or disorder, and / or a method for identifying an increased risk of developing a disease or disorder in an individual subject.SOLUTION: An aberrant level of a small molecule present in a sample from the individual subject is identified, and diagnostic information associated with the individual subject is obtained based on the identified aberrant level. The obtained diagnostic information includes one or more of an identification of at least one biochemical pathway associated with the identified subset of small molecules having abnormal levels, an identification of at least one disease or disorder associated with the identified subset of small molecules having abnormal levels, and an identification of at least one recommended follow-up test associated with the identified subset of small molecules having abnormal levels.SELECTED DRAWING: None