278 results about "Mass spectrometry" patented technology

The invention provides a nuclear magnetic resonance spectrogram analysis method and system, and relates to the technical field of mass spectrometry, and the method comprises the following steps: carrying out Fourier transform on an original FID signal of a to-be-detected solution to obtain a corresponding frequency domain signal; after carrying out phase correction processing on the frequency domain signal, determining positions of a plurality of candidate peaks from the frequency domain signal according to a second derivative; grouping the candidate peaks based on the distance parameter between the adjacent candidate peaks to obtain a plurality of first candidate peak groups; if the difference value between the maximum peak height and the minimum peak height of the candidate peaks is greater than a first preset threshold value, filtering partial candidate peaks in the first candidate peak group; if the difference value between the maximum peak value of the abnormal candidate peak group and the maximum peak value of the first candidate peak groups on the two sides is greater than a second preset threshold value, filtering the abnormal candidate peak group to obtain a target candidate peak group; and performing parameter fitting on the candidate peaks in the target candidate peak group by using a least square method, and determining the solvent peak position and the water peak position.

The invention relates to the technical field of Chinese patent medicine analysis, in particular to a chemical component systematic characterization method, a quality marker, a detection method and application of ginseng root strengthening oral liquid. According to the chemical component systematic characterization method provided by the invention, the chemical components in the ginseng root-consolidating oral liquid are detected by combining offline two-dimensional liquid chromatography and quadrupole rod high-resolution mass spectrometry, and the chemical component systematic characterization method not only can be used for systematic characterization of each component, but also can be used for further screening mass markers, so that the quality control of the ginseng root-consolidating oral liquid is favorably realized. The quality marker provided by the invention covers eight traditional Chinese medicines and eight structural types of compounds of the ginseng root-consolidating oral liquid, and can be used for overall quality control of the ginseng root-consolidating oral liquid. The detection method provided by the invention can be used for simply, quickly and quantitatively detecting the quality markers of the ginseng root strengthening oral liquid, and has very strong operability and practicability.

The invention discloses a CARS-LA-ICP-MS combined multimode analysis system. The CARS-LA-ICP-MS combined multimode analysis system comprises a fusion light path module, a mass spectrometry gas path module, a three-dimensional mobile station, a CARS signal acquisition system and a computer control system, the fusion light path module comprises a laser source, an optical parameter amplifier, a light pulse time delay system, three dichroscopes, a light beam adjusting system, a galvanometer, a movable objective lens and a camera; the mass spectrometry gas circuit module comprises a carrier gas supply device, a multimode analysis sample cell and a mass spectrometry device; the multimode analysis sample cell comprises an upper cover, a lower cover and a side wall shell. On the other hand, the invention discloses an analysis method which comprises initialization setting, CARS analysis, mass spectrum analysis task parameter setting, laser ablation mass spectrum analysis and data synthesis. Through coaxial optical path design and an intelligent algorithm, deep fusion of chemical imaging and elemental analysis is realized, and a brand new research tool is provided for the fields of life science, material science and the like.

A method for collaborative source apportionment of volatile organic compounds (VOCs), a product, a medium, and a device are provided. The method includes: establishing a single particle classification model; training and optimizing the single particle classification model with a local pollution library, and analyzing pollution sources of single particle mass spectrometric data to be apportioned to obtain a time series of the pollution sources contributing to the particulate matter (PM); obtaining VOCs factors of the pollution sources and a time series thereof; performing correlation calculation on the time series of the pollution sources contributing to the PM and the time series of the VOCs factors to obtain a correlation coefficient; and attributing the PM and the VOCs factor having the correlation coefficient higher than a set threshold to a same pollution source, and identifying a common pollution source of the PM and the VOCs.

The invention discloses a leak detector leak rate prediction method based on function fitting and correlation analysis, and relates to the technical field of helium mass spectrometer leak detector detection.The leak detector leak rate prediction method comprises the steps that a leak rate and time associated sequence corresponding to a leak hole is collected, function fitting processing is conducted on the leak rate and time associated sequence, and a leak rate attenuation feature model is obtained; then a real-time data fitting model corresponding to the leak hole is collected, correlation analysis is carried out on the real-time data fitting model and the corresponding leak rate attenuation feature model, and a correlation analysis result is determined; and finally, on the basis of the correlation analysis result, the leak rate of the leak hole is predicted, a leak rate prediction result is determined, the judgment time can be greatly shortened in any leak rate range, and the leak detection efficiency is greatly improved.

The invention relates to the technical field of solid fuel cells, and discloses a solid fuel cell tail gas heat energy cascade recycling system which comprises a tail gas component analysis module, a heat exchange topology construction module, a phase change heat storage control module, a residual pressure power generation adaptation module, a cascade scheduling decision module and a recycling efficiency monitoring module. The tail gas component analysis module generates a component concentration distribution map through mass spectrometry detection; the heat exchange topology construction module establishes a multi-stage heat exchanger network according to the atlas and optimizes parameters; the phase change heat storage control module deploys a phase change material array, divides a temperature control area and generates heat storage data; the excess pressure power generation adaptation module collects pressure signals and fits turbine characteristics to generate power generation parameters; the cascade scheduling decision module constructs a model through a dynamic programming algorithm and generates a scheduling instruction; and the reuse efficiency monitoring module tracks the state in real time and corrects parameters. The system realizes stepped recovery of tail gas heat energy, pressure energy and combustible components, improves energy efficiency and stability, and is suitable for solid fuel cell tail gas treatment.

The invention relates to the technical field of vacuum detection, in particular to a system for quickly judging whether a complex vacuum chamber has vacuum leakage or not. Aiming at the problem of vacuum leak detection, the invention provides the following technical scheme: the judgment system consists of a test vacuum chamber, a background vacuum chamber, a quadrupole mass spectrometer, a vacuum gauge tube and a vacuum unit; the test vacuum chamber is connected with the background vacuum chamber through a corrugated pipe; the vacuum gauge tube and the background vacuum chamber are connected through a CF35 knife edge sealing flange, and the quadrupole mass spectrometer and the background vacuum chamber are connected through a CF35 knife edge sealing flange. According to the invention, the leakage detection requirements of non-standard complex vacuum systems and various high-requirement vacuum systems in the nuclear fusion field at the present stage are met, and non-intrusive, rapid and high-reliability leakage judgment is realized through multi-interface adaptation, high-vacuum stable maintenance, dual precise monitoring and low-leakage-rate sealing design; the method is suitable for batch detection and on-line monitoring of fusion subsystems or engineering occasions with strict requirements for leak detection efficiency and accuracy.

The invention discloses a method for determining anthracene and phenanthrene oxides and polycyclic aromatic hydrocarbon pollutants in tea leaves, and belongs to the technical field of tea leaf component determination, by using the method, whether a tea leaf sample contains anthraquinone, phenanthrenequinone, multiple polycyclic aromatic hydrocarbons and other pollutants can be accurately determined at the same time, and quantitative analysis can be performed. The method has the characteristics of high detection efficiency, accurate analysis result and good repeatability; comprising the following steps: S1, respectively taking reference substances to prepare reference substance stock solutions with different numbers, taking a blank tea reference substance, and carrying out extraction, magnetic separation, extraction and elution to obtain a blank matrix extracting solution; s2, taking each reference substance stock solution, respectively preparing reference substance solutions with different numbers by using a blank matrix extracting solution, and sequentially putting the reference substance solutions into a gas chromatograph-tandem time-of-flight mass spectrometer for determination to obtain spectrum information of each reference substance; and S3, collecting data information of each reference substance from the map information of each reference substance, and then establishing a comparison database.

The application discloses a kind of artificial cells for single-cell mass spectrometry and preparation method thereof, wherein artificial cell includes internal water phase, intermediate oil phase and external water phase;Internal water phase includes polyethylene glycol and polyvinyl alcohol aqueous solution, intermediate oil phase includes L-alpha-phosphatidylcholine chloroform and hexane mixture;External water phase includes PVA and F-68 aqueous solution.Compared with natural cell sample, the novel artificial single cell based on microfluidic self-assembly developed in the application has better uniformity, stability and controllability, effectively avoids significant measurement difference between single-cell individual samples, and effectively solves the problem of difficult stable preservation of biological samples.The proposed artificial cell preparation method will largely solve the problem of lack of standard reference material in the field of single-cell mass spectrometry, making the results of single-cell mass spectrometry method more accurate, reliable and mutually recognized.

According to the salivation promoting beverage for treating diabetes and the preparation method and chemical and pharmacokinetic application of the salivation promoting beverage, eight medicinal and edible medicinal materials such as folium mori and radix rehmanniae are scientifically matched, and a material basis is laid for the blood glucose reducing effect of a compound through the design of a multi-component and multi-target synergistic effect. The absorption, distribution, metabolism and excretion processes of active ingredients in traditional Chinese medicinal materials in a living body can be systematically illuminated through pharmacokinetic research, meanwhile, strict methodology verification is carried out, a UHPLC-Q-TOF-MS high-resolution mass spectrometry technology and a modern pharmacokinetic application method are creatively integrated, and a set of systematic traditional Chinese medicine compound application strategy is constructed. Not only is the hypoglycemic action mechanism of the compound clarified, but also an innovative technical path and a reliable application normal form are provided for modern application of the traditional Chinese medicine compound, and organic combination of chemical characterization and efficacy evaluation is realized.

The application discloses a seminal plasma metabolic biomarker combination for male infertility spermatogenesis obstacle typing diagnosis, and relates to the field of biological science and technology.The application records the metabolic fingerprints of 475 seminal plasma samples by means of nanoparticle-enhanced laser desorption / ionization mass spectrometry, and constructs a seminal plasma metabolic fingerprint database related to spermatogenesis obstacle (SPGF). Then, through machine learning and statistical analysis, six metabolic biomarkers for SPGF typing diagnosis are screened and identified in the seminal plasma, and the six metabolic biomarkers can realize accurate typing of SPGF (AUC=0.814). The application has the advantages of simple sample pretreatment, fast analysis speed and low cost by means of recording the metabolic fingerprints of seminal plasma by means of nanoparticle-enhanced laser desorption / ionization mass spectrometry. Through the synthesized iron oxide nanoparticles as a matrix, small molecule metabolites in the seminal plasma can be efficiently captured and ionized, and complex pretreatment steps such as deproteinization and chromatographic separation are not needed, so that super-fast analysis, super-high sensitivity, extremely low sample consumption and excellent repeatability detection are realized.

The invention relates to the technical field of heat exchanger sealing performance detection, in particular to a heat exchanger sealing performance detection device, which is matched with a helium mass spectrometer leak detector to detect the tube pass sealing performance of a tube type heat exchanger, and comprises a rectangular frame and positioning wheels arranged at four corners of the rectangular frame, two detection mechanisms which are distributed up and down are arranged on the rectangular frame, each detection mechanism comprises a transverse sliding rail, a longitudinal sliding rail and a detection assembly, each detection assembly comprises a first suction gun which swings in a reciprocating mode and a second suction gun which moves along with the first suction gun, the tail end of each first suction gun points to the outer surface of the end of the tube bundle, and each second suction gun elastically moves front and back and extends into the tube bundle. The two suction guns are used for capturing helium in the annular welding position of the heat transfer tube and the tube plate and the interior of the heat transfer tube, so that leakage detection is carried out, detection errors caused by detection distance changes due to the fact that the suction guns are manually held by hands are reduced, and the efficiency of carrying out sealing performance detection on the large tubular heat exchanger is improved.

The invention relates to a separation qualitative and quantitative detection method for L-lactide, D-lactide and Meso-lactide, and belongs to the field of lactide optical purity detection.The separation qualitative and quantitative detection method comprises the following steps that firstly, various lactide standard curves of different configurations are established respectively, the concentration range of the standard curves is 10-1000 mg / L, and the concentration range of the standard curves is 10-1000 mg / L; the plurality of lactides with different configurations comprise one or more of L-lactide, D-lactide and Meso-lactide; and the lactide with different configurations comprises one or more of the L-lactide, the D-lactide and the Meso-lactide. 2, detecting by using a gas chromatograph-mass spectrometer, and quantitatively calculating a lactide substance to be detected, wherein the concentration range of the lactide substance to be detected is 200-1000mg / L; according to the invention, separation and quantitative detection of three lactide optical isomers are realized by using an analysis method; the influence of impurities in the to-be-detected substance of lactide on the accuracy of the quantitative result of lactide is reduced; qualitative and semi-quantitative information of the impurities in the to-be-detected substance is provided.

The invention relates to the technical field of vehicle-mounted liquid hydrogen cylinder detection, and discloses a vehicle-mounted liquid hydrogen cylinder vibration test method, which comprises the following steps: filling a gas cylinder with hollow glass beads of which the density is close to that of liquid hydrogen; the helium is cooled through a helium refrigerating device, and the helium is continuously introduced into the gas storage bottle, so that the temperature of the hollow glass beads is consistent with the temperature of the liquid hydrogen; sleeving a helium cover on the gas storage bottle, and vacuumizing the inside of the helium cover; formulating a vibration loading scheme according to the actual driving condition of the vehicle; in the vibration loading process, the concentration of helium in the helium cover is monitored in real time through a helium mass spectrometer leak detector, and if helium leakage is detected, the test is stopped; after vibration loading is finished, a helium mass spectrometer leak detector is used for detecting whether leakage occurs at the joints of the valve, the pipeline joint, the inner container and the shell of the gas storage cylinder or not; the heat insulation performance of the gas storage cylinder is judged; the structural integrity of the gas storage cylinder is detected through visual inspection and an ultrasonic detector; according to the method, liquid hydrogen working conditions are accurately simulated, test safety is guaranteed, and test efficiency is improved.

The method comprising obtaining a chromatogram of the sample, obtaining associated mass spectral data for each chromatogram peak of the plurality of chromatogram peaks, predicting fragments of each candidate chemical structure of a first plurality of candidate chemical structures, identifying a m / z ratio of at least one unique fragment of each candidate chemical structure of the first plurality of candidate chemical structures and, for one or more of the candidate chemical structure(s) of the first plurality of candidate chemical structures, assigning the candidate chemical structure to a chromatogram peak of the plurality of chromatogram peaks based on identifying one or more m / z peak(s) in the associated mass spectral data of the chromatogram peak at m / z ratio(s) corresponding to the m / z ratio(s) of the at least one unique fragment(s) of the candidate chemical structure. At least two of the candidate chemical structures of the first plurality of candidate chemical structures are candidate isomers. At least one of the assigned candidate chemical structure(s) is one of the candidate isomers.

The invention discloses a molten salt check valve helium leak detection device and method, and belongs to the technical field of molten salt check valves. The problems that in the prior art, leakage rate detection is inaccurate, and the leakage position is difficult to find are solved. According to the technical scheme, a helium source is sequentially connected with a first pressure gauge and a spray gun, the left side of a fused salt check valve is connected with a helium mass spectrometer leak detector and an auxiliary vacuum pump, and the right side of the fused salt check valve is sequentially connected with a second pressure gauge, a second electric stop valve, a second quick cut-off valve and a second release valve; and a calibration leak hole is formed in the fused salt check valve. According to different use conditions, a proper detection method can be selected to determine the leakage amount of a leakage point, and if a vacuum leakage detection test exceeds the standard, the method is continued to find out the position of the leakage point, so that repair is facilitated; detection cost is low, and equipment is simple; detection results are visual, and leakage positions are easy to judge.

This invention provides an application of ion emitters based on covalent organic framework materials in thermal ionization mass spectrometry (TIEMS), specifically for improving the ionization efficiency of uranium during TIEMS measurements. Compared to conventional dual-band source modes in TIEMS, and ionization enhancement techniques such as graphite methods, benzene vapor carburizing methods, and graphene oxide methods, this invention significantly improves uranium ionization efficiency, facilitating the accurate measurement of ultra-trace and low-abundance uranium isotopes.

The present application relates to the technical field of gas adsorption, and particularly provides a two-component gas competitive adsorption isotherm splitting method, aiming to solve the problem of high cost caused by mass flow meter + mass spectrometer or chromatography in the existing two-component gas competitive adsorption isotherm splitting. To this end, the two-component gas competitive adsorption isotherm splitting method comprises: controlling a weighing device to obtain the weight change of a sample after adsorption and the weight change of a sinker; obtaining the mass density of the mixed gas after adsorption based on the weight change; then obtaining the amount of substance of each of the mixed gas after adsorption; obtaining the residual amount of substance of each of the mixed gas after adsorption based on the amount of substance of the mixed gas after adsorption and the proportion of the amount of substance of each of the two-component gas after adsorption; further obtaining the proportion of the amount of adsorbed substance of each; and finally obtaining the adsorption mass of each based on the proportion of the amount of adsorbed substance of each of the two-component gas and the weight change Δm0 of the sample before and after adsorption.

The present application relates to a kind of detection systems for detecting the leak of the inner tube of vacuum insulated pipeline of test station, including the vacuum insulated pipeline for transmitting the low-temperature liquid generated by cryogenic refrigerator to distribution valve box, the vacuum insulated pipeline is connected with at least one helium mass spectrometer leak detector;Wherein, the vacuum insulated pipeline is welded by several prefabricated sections through corresponding transition section, each prefabricated section includes internal pipeline, external pipeline and vacuum interlayer between internal pipeline and external pipeline, vacuum safety plug is arranged on the external pipeline of each prefabricated section, and at least one prefabricated section is connected with an auxiliary evacuation system.The present application also relates to a kind of detection method for detecting the leak of the inner tube of vacuum insulated pipeline of test station.The present application realizes the detection of the inner tube of vacuum insulated pipeline section by section, can accurately and quickly determine the inner tube with leak, and quickly and accurately locate the leak range, improve detection efficiency and detection accuracy.

One embodiment of a fluororesin analysis device according to the present invention is a device that analyzes a fluororesin contained in a sample, and comprises: a measurement unit (1) that is a Py-CG / MS device; a chromatogram creation unit (222) that creates, from data collected using measurements performed on a target sample by the measurement unit, an EIC for fluorocarbon-derived fragment ions that are generated from thermal decomposition and has a specific m / z value; and an assessment unit (223, 224) that assesses whether a fluororesin is present by determining whether peak emergence has periodicity with respect to the retention time in the EIC. As a result, it can be assessed whether a sample contains a fluororesin even if there is no database for identifying the fluororesin.

The present application relates to a kind of method for simultaneously identifying 78 components in traditional Chinese medicine aloe barbadensis miller, using HPLC-DAD-ESI-IT-TOF-MS n The present application detects traditional Chinese medicine aloe barbadensis miller through specific mass spectrometry conditions and specific gradient elution program, so that the present application can simultaneously identify 78 components. In addition, in addition to the index components such as aloe-emodin, aloin D and aloin A, the present application can also simultaneously identify 14 compounds with pharmacological activity, which can more comprehensively and completely reflect the quality of traditional Chinese medicine aloe barbadensis miller, and is of great significance for the quality control of traditional Chinese medicine aloe barbadensis miller. Especially nowadays, the quality of traditional Chinese medicine aloe barbadensis miller on the market is uneven, and simultaneously identifying multiple index components with pharmacological activity is more important for quality evaluation. At the same time, the method of the present application has good repeatability and stability.

An IROA Matrix of metabolite compounds is disclosed. Each of whose compounds has a molecular weight of 2000 AMU or less, and is present as first and second isotopomers that are equally present at two predetermined isotopomeric balances, and contain 2 to 10% of a first isotope, and 90 to 98% of a second isotope, respectively. A reagent pair for transforming a natural abundance mass spectral analysis metabolite sample into an IROA sample is also disclosed and comprises two reactively identical reagents that constitute first and second isotopomers containing 2 to 10% of a first isotope, and 90 to 98% of a second isotope, respectively. Each of the reagent pair contains the same reactive group that reacts with and bonds to a functional group of one or more compounds present in a composition of biologically-produced metabolite compounds. Methods of making and using the above and related materials are also disclosed.

The application relates to the technical field of vacuum measurement, in particular to a water and methane mixed gas preparation device and method for a moon exploration mass spectrometer, which comprises a water gas preparation chamber, a water gas bottle, a pressure stabilizing chamber, a moon exploration mass spectrometer, a methane gas bottle and a gas extraction system, wherein: a metal container is arranged in the water gas preparation chamber; the water gas bottle is connected with the pressure stabilizing chamber through a first valve and connected with the water gas preparation chamber through a seventh valve; the methane gas bottle is connected with the pressure stabilizing chamber through a second valve; the pressure stabilizing chamber is connected with the moon exploration mass spectrometer through a fifth valve and a small hole; and the gas extraction system comprises a first gas extraction system, a second gas extraction system and a third gas extraction system. The standard water gas is prepared through a liquid nitrogen freezing and air extraction method, and the mixed gas configuration of methane and water gas is completed, so that the problems of water gas preparation and water and methane mixing under the water strong adsorption are solved.

The invention provides a connector flange leak rate rapid detection device and method. The connector flange leak rate rapid detection device comprises a helium tank, a pressure reducing valve, a spray gun, a passive standard leak hole, a stop valve, a connector, a connector flange, a flange overall leak detection tool, a vacuum corrugated pipe and a helium mass spectrometer leak detector. A cavity is formed in the flange integral leakage detection tool, and a flange interface is formed on the edge of the top of the upward opening; a connector flange to be detected is placed above a flange interface of the flange integral leak detection tool and is in sealed connection with the flange interface, and a connector is inserted into the connector flange to be detected. The helium mass spectrometer leak detector is connected to the interior of the flange integral leak detection tool through a vacuum corrugated pipe; the passive standard leak hole is connected to the interior of the flange integral leak detection tool through a stop valve. The spray gun is connected to the helium tank through the pressure reducing valve, and a nozzle of the spray gun faces the connector. According to the invention, the overall leakage rate of the connector flange can be rapidly detected, the leakage point of the connector flange can be rapidly positioned, and the workload of the leakage rate detection of the connector flange can be reduced.

The application relates to a high-throughput identification method of lncRNA coding peptides and application thereof, and belongs to the technical field of biology. The method combines a translationomics technology and a protein mass spectrometry technology, takes ribosome footprint sequencing data as a starting point, determines an open reading frame located on an lncRNA gene according to a three-base periodicity rule of a sequencing fragment, further constructs a proteogenomics index after systematic filtration, uses a computational proteomics method to detect an lncRNA translation event, and systematically identifies lncRNA coding peptides on the basis. The method has the characteristics of modularity and strong expandability, can be widely used for various types of proteome data, and can high-throughput identify and quantitatively detect lncRNA coding peptides. The application provides a prediction of molecular typing and prognosis of cancer patients based on an lncRNA coding peptide network model, and provides an important reference basis for precise medication of clinical patients.

The application discloses a battery box for immersion direct cooling, and belongs to the technical field of battery thermal management. The battery box comprises a box body and a cover plate, and forms a closed chamber. The bottom plate of the box body is provided with a module support frame, so that the battery module is kept at a gap of 0.5-2.5 cm with the bottom plate and a gap of 1-5 cm with the side wall. At least one wall of the box body is provided with an arc-shaped flow uniforming plate, the included angle between the tangent of the edge of the flow uniforming plate and the reference plane is 5-37 degrees, and the height of the flow uniforming plate is 1 / 3-1 times the height of the battery cell. The angle of the flow uniforming plate is adjustable, the 0-90-degree adjustment is realized through a hinged mechanism with an arc-shaped sliding groove, the bottom spring device makes the inclination angle change automatically with the flow rate, and the angle of the base can be automatically adjusted according to the preset judgment rule based on the temperature rise rate and the temperature difference of the thermocouple transmission. The box body is provided with a safety pressure relief valve. The liquid inlet is provided on the opposite wall of the box body to form liquid hedging, the liquid outlet is provided on the cover plate, and the connecting direction of the liquid inlet is the same as the thickness direction of the battery cell. The box body is subjected to 1.5 times working pressure hydrostatic pressure test and helium mass spectrometry leak detection verification, and the leakage rate is less than or equal to 1*10-3 Pa*m3 / s. The application can significantly improve the battery temperature consistency, reduce the temperature rise, prolong the battery life and improve the system safety under the condition of low pump consumption.

The invention discloses an emblic leafflower fruit milk processing technology optimization method based on a single factor and pharmacodynamic experiment, and belongs to the technical field of traditional Chinese medicine processing, and the method comprises the following steps: screening out optimal technological parameters through the single factor experiment: mixing emblic leafflower fruit and raw milk according to a material-liquid ratio of 1: 15, soaking at 45 + / -5 DEG C for 12 hours, cleaning milk stains, naturally air-drying for 2 hours, and drying at 50 DEG C for 24-48 hours until the water content is less than 6%. A liquid chromatography-tandem high-resolution mass spectrometry technology is adopted for analysis and displaying that the content of gallic acid, ellagic acid and corilagin in a processed product is remarkably reduced. Pharmacodynamic experiments prove that the toxicity of the processed product to WRL68 hepatocytes and 293T renal cells is weakened, the survival rate of the hepatocytes and the renal cells is increased along with reduction of the concentration of the components, and the toxicity reduction effect is achieved. The technological parameters are clear, the quality is stable, and a scientific basis is provided for standardized production and clinical safe medication of emblic leafflower fruit milk processing.

The invention discloses an MOF-derived heterojunction, a preparation method thereof and application of the MOF-derived heterojunction in metabolism detection, and relates to the technical field of heterojunction material preparation. The preparation method comprises the following steps: performing first-stage heat treatment on an MOF precursor to prepare a metal oxide, and reacting the metal oxide with a titanium source to obtain a product; or directly reacting the MOF precursor with a titanium source to obtain a product; and carrying out second-stage heat treatment on the product in an inert atmosphere or air to obtain the MOF-derived heterojunction. The invention relates to application of MOF-derived heterojunction as a matrix in detection of serum metabolic fingerprints by laser desorption / ionization mass spectrometry and application in construction of a disease diagnosis model. The heterojunction material prepared by the invention has the advantages of high ionization efficiency, good photothermal effect and strong biological matrix interference resistance, and can be used as an LDI MS nano matrix to be applied to respiratory disease serum metabolism fingerprint diagnosis and disease diagnosis models so as to distinguish respiratory diseases.

The invention discloses an air tightness detection device for a corrugated pipe compensator. The air tightness detection device comprises a first blind flange, a second blind flange, a fastening assembly, a sealing assembly, an air exhaust connecting pipe, vacuumizing equipment, a vacuum gauge, a vacuum baffle valve, a helium mass spectrometer leak detector and an external helium spray gun. The invention also discloses a bellows compensator air tightness detection method. The method comprises the following steps: S1, assembling and sealing; s2, performing initial inspection; s3, vacuumizing is carried out; s4, maintaining pressure and observing; and S5, judging a result. The technical scheme of combining negative pressure vacuum and helium mass spectrum leak detection is adopted, the characteristics that helium molecules are small in diameter, low in background content and high in response speed are utilized, the leak detection sensitivity is extremely high and is far superior to a traditional bubble method, a negative pressure maintaining method and an SFsniffing method, high-precision detection can be stably achieved, and the leak detection accuracy is greatly improved. The device can meet the requirements of extra-high-voltage GIL pipelines, chemical high-risk medium pipelines and other scenes with extremely high requirements for sealing performance, and the reliability and accuracy of detection results are greatly improved.

This utility model relates to the field of leak detection technology for ceramic orifice plate heater assemblies, and discloses a tooling for leak detection of ceramic orifice plate heater assemblies, including a leak detection tooling base and a leak detection tooling cover. The upper end of the leak detection tooling base is provided with an annular sealing structure that seals with the bottom of the ceramic orifice plate heater assembly, and the lower end is provided with an interface adapted to a helium mass spectrometer leak detector. The leak detection tooling cover is provided with a conical sealing structure that matches the shape of the outer wall of the metal gas cone of the ceramic orifice plate heater assembly, and the top of the leak detection tooling cover is provided with a narrow-hole sealing structure. The annular sealing structure is a first annular groove, and the conical sealing structure is a second annular groove. The upper end of the leak detection tooling base is also provided with two symmetrically distributed positioning holes, the center distance of which is the same as the mounting hole distance of the metal rivets at the bottom of the ceramic orifice plate heater assembly. This utility model has a simple structure, good sealing performance, and can effectively detect the airtightness of ceramic orifice plate heater assemblies.