174 results about "Mass spectrometry" patented technology

The invention discloses a CARS-LA-ICP-MS combined multimode analysis system. The CARS-LA-ICP-MS combined multimode analysis system comprises a fusion light path module, a mass spectrometry gas path module, a three-dimensional mobile station, a CARS signal acquisition system and a computer control system, the fusion light path module comprises a laser source, an optical parameter amplifier, a light pulse time delay system, three dichroscopes, a light beam adjusting system, a galvanometer, a movable objective lens and a camera; the mass spectrometry gas circuit module comprises a carrier gas supply device, a multimode analysis sample cell and a mass spectrometry device; the multimode analysis sample cell comprises an upper cover, a lower cover and a side wall shell. On the other hand, the invention discloses an analysis method which comprises initialization setting, CARS analysis, mass spectrum analysis task parameter setting, laser ablation mass spectrum analysis and data synthesis. Through coaxial optical path design and an intelligent algorithm, deep fusion of chemical imaging and elemental analysis is realized, and a brand new research tool is provided for the fields of life science, material science and the like.

The invention discloses a leak detector leak rate prediction method based on function fitting and correlation analysis, and relates to the technical field of helium mass spectrometer leak detector detection.The leak detector leak rate prediction method comprises the steps that a leak rate and time associated sequence corresponding to a leak hole is collected, function fitting processing is conducted on the leak rate and time associated sequence, and a leak rate attenuation feature model is obtained; then a real-time data fitting model corresponding to the leak hole is collected, correlation analysis is carried out on the real-time data fitting model and the corresponding leak rate attenuation feature model, and a correlation analysis result is determined; and finally, on the basis of the correlation analysis result, the leak rate of the leak hole is predicted, a leak rate prediction result is determined, the judgment time can be greatly shortened in any leak rate range, and the leak detection efficiency is greatly improved.

The invention discloses a method for determining anthracene and phenanthrene oxides and polycyclic aromatic hydrocarbon pollutants in tea leaves, and belongs to the technical field of tea leaf component determination, by using the method, whether a tea leaf sample contains anthraquinone, phenanthrenequinone, multiple polycyclic aromatic hydrocarbons and other pollutants can be accurately determined at the same time, and quantitative analysis can be performed. The method has the characteristics of high detection efficiency, accurate analysis result and good repeatability; comprising the following steps: S1, respectively taking reference substances to prepare reference substance stock solutions with different numbers, taking a blank tea reference substance, and carrying out extraction, magnetic separation, extraction and elution to obtain a blank matrix extracting solution; s2, taking each reference substance stock solution, respectively preparing reference substance solutions with different numbers by using a blank matrix extracting solution, and sequentially putting the reference substance solutions into a gas chromatograph-tandem time-of-flight mass spectrometer for determination to obtain spectrum information of each reference substance; and S3, collecting data information of each reference substance from the map information of each reference substance, and then establishing a comparison database.

The application discloses a kind of artificial cells for single-cell mass spectrometry and preparation method thereof, wherein artificial cell includes internal water phase, intermediate oil phase and external water phase;Internal water phase includes polyethylene glycol and polyvinyl alcohol aqueous solution, intermediate oil phase includes L-alpha-phosphatidylcholine chloroform and hexane mixture;External water phase includes PVA and F-68 aqueous solution.Compared with natural cell sample, the novel artificial single cell based on microfluidic self-assembly developed in the application has better uniformity, stability and controllability, effectively avoids significant measurement difference between single-cell individual samples, and effectively solves the problem of difficult stable preservation of biological samples.The proposed artificial cell preparation method will largely solve the problem of lack of standard reference material in the field of single-cell mass spectrometry, making the results of single-cell mass spectrometry method more accurate, reliable and mutually recognized.

According to the salivation promoting beverage for treating diabetes and the preparation method and chemical and pharmacokinetic application of the salivation promoting beverage, eight medicinal and edible medicinal materials such as folium mori and radix rehmanniae are scientifically matched, and a material basis is laid for the blood glucose reducing effect of a compound through the design of a multi-component and multi-target synergistic effect. The absorption, distribution, metabolism and excretion processes of active ingredients in traditional Chinese medicinal materials in a living body can be systematically illuminated through pharmacokinetic research, meanwhile, strict methodology verification is carried out, a UHPLC-Q-TOF-MS high-resolution mass spectrometry technology and a modern pharmacokinetic application method are creatively integrated, and a set of systematic traditional Chinese medicine compound application strategy is constructed. Not only is the hypoglycemic action mechanism of the compound clarified, but also an innovative technical path and a reliable application normal form are provided for modern application of the traditional Chinese medicine compound, and organic combination of chemical characterization and efficacy evaluation is realized.

The application discloses a seminal plasma metabolic biomarker combination for male infertility spermatogenesis obstacle typing diagnosis, and relates to the field of biological science and technology.The application records the metabolic fingerprints of 475 seminal plasma samples by means of nanoparticle-enhanced laser desorption / ionization mass spectrometry, and constructs a seminal plasma metabolic fingerprint database related to spermatogenesis obstacle (SPGF). Then, through machine learning and statistical analysis, six metabolic biomarkers for SPGF typing diagnosis are screened and identified in the seminal plasma, and the six metabolic biomarkers can realize accurate typing of SPGF (AUC=0.814). The application has the advantages of simple sample pretreatment, fast analysis speed and low cost by means of recording the metabolic fingerprints of seminal plasma by means of nanoparticle-enhanced laser desorption / ionization mass spectrometry. Through the synthesized iron oxide nanoparticles as a matrix, small molecule metabolites in the seminal plasma can be efficiently captured and ionized, and complex pretreatment steps such as deproteinization and chromatographic separation are not needed, so that super-fast analysis, super-high sensitivity, extremely low sample consumption and excellent repeatability detection are realized.

The invention relates to the technical field of heat exchanger sealing performance detection, in particular to a heat exchanger sealing performance detection device, which is matched with a helium mass spectrometer leak detector to detect the tube pass sealing performance of a tube type heat exchanger, and comprises a rectangular frame and positioning wheels arranged at four corners of the rectangular frame, two detection mechanisms which are distributed up and down are arranged on the rectangular frame, each detection mechanism comprises a transverse sliding rail, a longitudinal sliding rail and a detection assembly, each detection assembly comprises a first suction gun which swings in a reciprocating mode and a second suction gun which moves along with the first suction gun, the tail end of each first suction gun points to the outer surface of the end of the tube bundle, and each second suction gun elastically moves front and back and extends into the tube bundle. The two suction guns are used for capturing helium in the annular welding position of the heat transfer tube and the tube plate and the interior of the heat transfer tube, so that leakage detection is carried out, detection errors caused by detection distance changes due to the fact that the suction guns are manually held by hands are reduced, and the efficiency of carrying out sealing performance detection on the large tubular heat exchanger is improved.

The invention relates to a separation qualitative and quantitative detection method for L-lactide, D-lactide and Meso-lactide, and belongs to the field of lactide optical purity detection.The separation qualitative and quantitative detection method comprises the following steps that firstly, various lactide standard curves of different configurations are established respectively, the concentration range of the standard curves is 10-1000 mg / L, and the concentration range of the standard curves is 10-1000 mg / L; the plurality of lactides with different configurations comprise one or more of L-lactide, D-lactide and Meso-lactide; and the lactide with different configurations comprises one or more of the L-lactide, the D-lactide and the Meso-lactide. 2, detecting by using a gas chromatograph-mass spectrometer, and quantitatively calculating a lactide substance to be detected, wherein the concentration range of the lactide substance to be detected is 200-1000mg / L; according to the invention, separation and quantitative detection of three lactide optical isomers are realized by using an analysis method; the influence of impurities in the to-be-detected substance of lactide on the accuracy of the quantitative result of lactide is reduced; qualitative and semi-quantitative information of the impurities in the to-be-detected substance is provided.

The invention relates to the technical field of vehicle-mounted liquid hydrogen cylinder detection, and discloses a vehicle-mounted liquid hydrogen cylinder vibration test method, which comprises the following steps: filling a gas cylinder with hollow glass beads of which the density is close to that of liquid hydrogen; the helium is cooled through a helium refrigerating device, and the helium is continuously introduced into the gas storage bottle, so that the temperature of the hollow glass beads is consistent with the temperature of the liquid hydrogen; sleeving a helium cover on the gas storage bottle, and vacuumizing the inside of the helium cover; formulating a vibration loading scheme according to the actual driving condition of the vehicle; in the vibration loading process, the concentration of helium in the helium cover is monitored in real time through a helium mass spectrometer leak detector, and if helium leakage is detected, the test is stopped; after vibration loading is finished, a helium mass spectrometer leak detector is used for detecting whether leakage occurs at the joints of the valve, the pipeline joint, the inner container and the shell of the gas storage cylinder or not; the heat insulation performance of the gas storage cylinder is judged; the structural integrity of the gas storage cylinder is detected through visual inspection and an ultrasonic detector; according to the method, liquid hydrogen working conditions are accurately simulated, test safety is guaranteed, and test efficiency is improved.

The invention discloses a molten salt check valve helium leak detection device and method, and belongs to the technical field of molten salt check valves. The problems that in the prior art, leakage rate detection is inaccurate, and the leakage position is difficult to find are solved. According to the technical scheme, a helium source is sequentially connected with a first pressure gauge and a spray gun, the left side of a fused salt check valve is connected with a helium mass spectrometer leak detector and an auxiliary vacuum pump, and the right side of the fused salt check valve is sequentially connected with a second pressure gauge, a second electric stop valve, a second quick cut-off valve and a second release valve; and a calibration leak hole is formed in the fused salt check valve. According to different use conditions, a proper detection method can be selected to determine the leakage amount of a leakage point, and if a vacuum leakage detection test exceeds the standard, the method is continued to find out the position of the leakage point, so that repair is facilitated; detection cost is low, and equipment is simple; detection results are visual, and leakage positions are easy to judge.

This invention provides an application of ion emitters based on covalent organic framework materials in thermal ionization mass spectrometry (TIEMS), specifically for improving the ionization efficiency of uranium during TIEMS measurements. Compared to conventional dual-band source modes in TIEMS, and ionization enhancement techniques such as graphite methods, benzene vapor carburizing methods, and graphene oxide methods, this invention significantly improves uranium ionization efficiency, facilitating the accurate measurement of ultra-trace and low-abundance uranium isotopes.

The present application relates to the technical field of gas adsorption, and particularly provides a two-component gas competitive adsorption isotherm splitting method, aiming to solve the problem of high cost caused by mass flow meter + mass spectrometer or chromatography in the existing two-component gas competitive adsorption isotherm splitting. To this end, the two-component gas competitive adsorption isotherm splitting method comprises: controlling a weighing device to obtain the weight change of a sample after adsorption and the weight change of a sinker; obtaining the mass density of the mixed gas after adsorption based on the weight change; then obtaining the amount of substance of each of the mixed gas after adsorption; obtaining the residual amount of substance of each of the mixed gas after adsorption based on the amount of substance of the mixed gas after adsorption and the proportion of the amount of substance of each of the two-component gas after adsorption; further obtaining the proportion of the amount of adsorbed substance of each; and finally obtaining the adsorption mass of each based on the proportion of the amount of adsorbed substance of each of the two-component gas and the weight change Δm0 of the sample before and after adsorption.

The present application relates to a kind of detection systems for detecting the leak of the inner tube of vacuum insulated pipeline of test station, including the vacuum insulated pipeline for transmitting the low-temperature liquid generated by cryogenic refrigerator to distribution valve box, the vacuum insulated pipeline is connected with at least one helium mass spectrometer leak detector;Wherein, the vacuum insulated pipeline is welded by several prefabricated sections through corresponding transition section, each prefabricated section includes internal pipeline, external pipeline and vacuum interlayer between internal pipeline and external pipeline, vacuum safety plug is arranged on the external pipeline of each prefabricated section, and at least one prefabricated section is connected with an auxiliary evacuation system.The present application also relates to a kind of detection method for detecting the leak of the inner tube of vacuum insulated pipeline of test station.The present application realizes the detection of the inner tube of vacuum insulated pipeline section by section, can accurately and quickly determine the inner tube with leak, and quickly and accurately locate the leak range, improve detection efficiency and detection accuracy.

One embodiment of a fluororesin analysis device according to the present invention is a device that analyzes a fluororesin contained in a sample, and comprises: a measurement unit (1) that is a Py-CG / MS device; a chromatogram creation unit (222) that creates, from data collected using measurements performed on a target sample by the measurement unit, an EIC for fluorocarbon-derived fragment ions that are generated from thermal decomposition and has a specific m / z value; and an assessment unit (223, 224) that assesses whether a fluororesin is present by determining whether peak emergence has periodicity with respect to the retention time in the EIC. As a result, it can be assessed whether a sample contains a fluororesin even if there is no database for identifying the fluororesin.

The present application relates to a kind of method for simultaneously identifying 78 components in traditional Chinese medicine aloe barbadensis miller, using HPLC-DAD-ESI-IT-TOF-MS n The present application detects traditional Chinese medicine aloe barbadensis miller through specific mass spectrometry conditions and specific gradient elution program, so that the present application can simultaneously identify 78 components. In addition, in addition to the index components such as aloe-emodin, aloin D and aloin A, the present application can also simultaneously identify 14 compounds with pharmacological activity, which can more comprehensively and completely reflect the quality of traditional Chinese medicine aloe barbadensis miller, and is of great significance for the quality control of traditional Chinese medicine aloe barbadensis miller. Especially nowadays, the quality of traditional Chinese medicine aloe barbadensis miller on the market is uneven, and simultaneously identifying multiple index components with pharmacological activity is more important for quality evaluation. At the same time, the method of the present application has good repeatability and stability.

An IROA Matrix of metabolite compounds is disclosed. Each of whose compounds has a molecular weight of 2000 AMU or less, and is present as first and second isotopomers that are equally present at two predetermined isotopomeric balances, and contain 2 to 10% of a first isotope, and 90 to 98% of a second isotope, respectively. A reagent pair for transforming a natural abundance mass spectral analysis metabolite sample into an IROA sample is also disclosed and comprises two reactively identical reagents that constitute first and second isotopomers containing 2 to 10% of a first isotope, and 90 to 98% of a second isotope, respectively. Each of the reagent pair contains the same reactive group that reacts with and bonds to a functional group of one or more compounds present in a composition of biologically-produced metabolite compounds. Methods of making and using the above and related materials are also disclosed.

The invention provides a connector flange leak rate rapid detection device and method. The connector flange leak rate rapid detection device comprises a helium tank, a pressure reducing valve, a spray gun, a passive standard leak hole, a stop valve, a connector, a connector flange, a flange overall leak detection tool, a vacuum corrugated pipe and a helium mass spectrometer leak detector. A cavity is formed in the flange integral leakage detection tool, and a flange interface is formed on the edge of the top of the upward opening; a connector flange to be detected is placed above a flange interface of the flange integral leak detection tool and is in sealed connection with the flange interface, and a connector is inserted into the connector flange to be detected. The helium mass spectrometer leak detector is connected to the interior of the flange integral leak detection tool through a vacuum corrugated pipe; the passive standard leak hole is connected to the interior of the flange integral leak detection tool through a stop valve. The spray gun is connected to the helium tank through the pressure reducing valve, and a nozzle of the spray gun faces the connector. According to the invention, the overall leakage rate of the connector flange can be rapidly detected, the leakage point of the connector flange can be rapidly positioned, and the workload of the leakage rate detection of the connector flange can be reduced.

The application relates to a high-throughput identification method of lncRNA coding peptides and application thereof, and belongs to the technical field of biology. The method combines a translationomics technology and a protein mass spectrometry technology, takes ribosome footprint sequencing data as a starting point, determines an open reading frame located on an lncRNA gene according to a three-base periodicity rule of a sequencing fragment, further constructs a proteogenomics index after systematic filtration, uses a computational proteomics method to detect an lncRNA translation event, and systematically identifies lncRNA coding peptides on the basis. The method has the characteristics of modularity and strong expandability, can be widely used for various types of proteome data, and can high-throughput identify and quantitatively detect lncRNA coding peptides. The application provides a prediction of molecular typing and prognosis of cancer patients based on an lncRNA coding peptide network model, and provides an important reference basis for precise medication of clinical patients.

The application discloses a battery box for immersion direct cooling, and belongs to the technical field of battery thermal management. The battery box comprises a box body and a cover plate, and forms a closed chamber. The bottom plate of the box body is provided with a module support frame, so that the battery module is kept at a gap of 0.5-2.5 cm with the bottom plate and a gap of 1-5 cm with the side wall. At least one wall of the box body is provided with an arc-shaped flow uniforming plate, the included angle between the tangent of the edge of the flow uniforming plate and the reference plane is 5-37 degrees, and the height of the flow uniforming plate is 1 / 3-1 times the height of the battery cell. The angle of the flow uniforming plate is adjustable, the 0-90-degree adjustment is realized through a hinged mechanism with an arc-shaped sliding groove, the bottom spring device makes the inclination angle change automatically with the flow rate, and the angle of the base can be automatically adjusted according to the preset judgment rule based on the temperature rise rate and the temperature difference of the thermocouple transmission. The box body is provided with a safety pressure relief valve. The liquid inlet is provided on the opposite wall of the box body to form liquid hedging, the liquid outlet is provided on the cover plate, and the connecting direction of the liquid inlet is the same as the thickness direction of the battery cell. The box body is subjected to 1.5 times working pressure hydrostatic pressure test and helium mass spectrometry leak detection verification, and the leakage rate is less than or equal to 1*10-3 Pa*m3 / s. The application can significantly improve the battery temperature consistency, reduce the temperature rise, prolong the battery life and improve the system safety under the condition of low pump consumption.

The invention discloses an MOF-derived heterojunction, a preparation method thereof and application of the MOF-derived heterojunction in metabolism detection, and relates to the technical field of heterojunction material preparation. The preparation method comprises the following steps: performing first-stage heat treatment on an MOF precursor to prepare a metal oxide, and reacting the metal oxide with a titanium source to obtain a product; or directly reacting the MOF precursor with a titanium source to obtain a product; and carrying out second-stage heat treatment on the product in an inert atmosphere or air to obtain the MOF-derived heterojunction. The invention relates to application of MOF-derived heterojunction as a matrix in detection of serum metabolic fingerprints by laser desorption / ionization mass spectrometry and application in construction of a disease diagnosis model. The heterojunction material prepared by the invention has the advantages of high ionization efficiency, good photothermal effect and strong biological matrix interference resistance, and can be used as an LDI MS nano matrix to be applied to respiratory disease serum metabolism fingerprint diagnosis and disease diagnosis models so as to distinguish respiratory diseases.

The invention discloses an air tightness detection device for a corrugated pipe compensator. The air tightness detection device comprises a first blind flange, a second blind flange, a fastening assembly, a sealing assembly, an air exhaust connecting pipe, vacuumizing equipment, a vacuum gauge, a vacuum baffle valve, a helium mass spectrometer leak detector and an external helium spray gun. The invention also discloses a bellows compensator air tightness detection method. The method comprises the following steps: S1, assembling and sealing; s2, performing initial inspection; s3, vacuumizing is carried out; s4, maintaining pressure and observing; and S5, judging a result. The technical scheme of combining negative pressure vacuum and helium mass spectrum leak detection is adopted, the characteristics that helium molecules are small in diameter, low in background content and high in response speed are utilized, the leak detection sensitivity is extremely high and is far superior to a traditional bubble method, a negative pressure maintaining method and an SFsniffing method, high-precision detection can be stably achieved, and the leak detection accuracy is greatly improved. The device can meet the requirements of extra-high-voltage GIL pipelines, chemical high-risk medium pipelines and other scenes with extremely high requirements for sealing performance, and the reliability and accuracy of detection results are greatly improved.

This utility model relates to the field of leak detection technology for ceramic orifice plate heater assemblies, and discloses a tooling for leak detection of ceramic orifice plate heater assemblies, including a leak detection tooling base and a leak detection tooling cover. The upper end of the leak detection tooling base is provided with an annular sealing structure that seals with the bottom of the ceramic orifice plate heater assembly, and the lower end is provided with an interface adapted to a helium mass spectrometer leak detector. The leak detection tooling cover is provided with a conical sealing structure that matches the shape of the outer wall of the metal gas cone of the ceramic orifice plate heater assembly, and the top of the leak detection tooling cover is provided with a narrow-hole sealing structure. The annular sealing structure is a first annular groove, and the conical sealing structure is a second annular groove. The upper end of the leak detection tooling base is also provided with two symmetrically distributed positioning holes, the center distance of which is the same as the mounting hole distance of the metal rivets at the bottom of the ceramic orifice plate heater assembly. This utility model has a simple structure, good sealing performance, and can effectively detect the airtightness of ceramic orifice plate heater assemblies.

The invention relates to the technical field of pesticide residue detection, in particular to a pesticide residue detection method which comprises the following steps: (1) freezing and crushing a sample, and performing microwave extraction to obtain extract liquor; (2) detecting and analyzing the extract by adopting a gas chromatograph-mass spectrometer, and determining the content of pesticide residues in the sample; the gas chromatography conditions of the gas chromatograph-mass spectrometer are as follows: a chromatographic column heating procedure is as follows: the temperature is kept for 1-2 minutes at the temperature of 100-110 DEG C, the temperature is raised to 220-230 DEG C at the heating rate of 10-15 DEG C / min, then the temperature is raised to 320-330 DEG C at the heating rate of 20-25 DEG C / min, and the temperature is kept for 3-3.5 minutes. Pretreatment and detection conditions in the method are optimized, rapid and accurate detection of the pesticide residues in the fruit and vegetable food is achieved, the method is simple, and monitoring of the pesticide residues is easy to promote.

The invention discloses a double-backing-pump helium mass spectrometer leak detector with switchable gas extraction modes, and belongs to the field of helium mass spectrometer leak detectors, the double-backing-pump helium mass spectrometer leak detector comprises a detection box, the top surface end of the detection box is provided with a leak detection port, the detection box is internally provided with a gas extraction system, and the gas extraction system comprises a first backing pump and a second backing pump which are arranged in the detection box. A first pipeline is connected to an extraction opening of the first backing pump, the end, away from the first backing pump, of the first pipeline is inserted and fixed to the bottom end of the leakage detection opening, a second pipeline is connected to an extraction opening of the second backing pump, the end, away from the second backing pump, of the second pipeline is fixed to the peripheral face of the first pipeline, and a third pipeline is connected to an air outlet of the first backing pump. The end, away from the first backing pump, of the third pipeline is fixed to the peripheral face of the second pipeline, a first electromagnetic valve is arranged on the third pipeline, a second electromagnetic valve is arranged on the second pipeline, an exhaust pipe is fixed to the peripheral face of the third pipeline, and a third electromagnetic valve is arranged on the exhaust pipe. The helium mass spectrometer leak detector has the effects of reducing the pollution of the cavity of the helium mass spectrometer leak detector and improving the vacuum degree and the sensitivity of the mass spectrometer detection chamber.

This invention discloses a calorimetric and infrared (IR) coupled device and method capable of simultaneously detecting the strength and state of solid-gas (liquid) interactions. The device, combined with a calorimeter having a measuring channel and an infrared measurement module, can simultaneously measure the strength and state of solid-gas (liquid) interactions. This invention also discloses a method for studying and detecting the strength and state of solid-gas (liquid) interactions. The amount of gas or liquid involved in the interaction is obtained by subtracting the amount of gas or liquid after the interaction from the initial mass of the gas or liquid, and the amount of substance is quantitatively obtained through a mass spectrometer connected to the device. The calorimetric and infrared coupled device and method disclosed in this invention can simultaneously obtain the strength and state of solid-gas (liquid) interactions in a single experiment.

1. The name of the design product: helium mass spectrometer leak detector. 2. The use of the design product: for sealed objects, leak point positioning and quantitative detection instrument. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective drawing.

The application provides a sealing detection method of an ultrahigh vacuum exhaust device, relates to the technical field of sealing detection, and comprises the following steps: performing leakage risk feature mining on the ultrahigh vacuum exhaust device, and constructing a detection point distribution; performing vacuum pumping smooth detection on the ultrahigh vacuum exhaust device, and generating a sealing detection starting signal according to a smooth detection result; performing sealing detection on the ultrahigh vacuum exhaust device according to the detection point distribution and a helium mass spectrometer leak detector, and obtaining a first device sealing detection result; and performing detection background interference correction, helium injection cross-influence compensation and material helium adsorption correction on the first device sealing detection result, and generating a fourth device sealing detection result. The application solves the technical problem that, due to the existence of various interference factors, misjudgment and omission are prone to occur, and the sealing detection precision is insufficient, the detection is performed after vacuum smoothing, the detection result is corrected, and the sealing detection effect of the ultrahigh vacuum exhaust device is improved.

This invention discloses a helium leak detection system and method for supercapacitors. The system includes a sealed leak detection chamber, a vacuum pumping unit, a helium supply and recovery unit, and a helium mass spectrometer leak detector. The hollow sealed leak detection chamber is used to hold the capacitor to be tested. The sealed leak detection chamber is connected to the vacuum pumping unit, the helium supply and recovery unit, and the helium mass spectrometer leak detector. The vacuum pumping unit is used to perform a vacuum pumping operation inside the sealed leak detection chamber. The helium supply and recovery unit is used to fill the sealed leak detection chamber with a mixture of helium and nitrogen gas, and to recover and store the helium in the mixture. The helium mass spectrometer leak detector is used to detect the change in helium concentration in the sealed leak detection chamber in real time and convert the detected helium concentration signal into leak rate data. This invention is scientifically designed, has high detection accuracy, and can accurately detect the sealing performance of capacitors, determine whether there is a leakage problem, improve detection efficiency, and reduce detection costs.

The application relates to the technical field of plant chemistry and active ingredient heterocyclic compounds of traditional Chinese medicine, and discloses a C17 sesquiterpene alkaloid, a preparation method and application, wherein the C17 sesquiterpene alkaloid and a pharmaceutically acceptable salt thereof are shown as formula I; the C17 sesquiterpene alkaloid of formula I is separated from an ethanol extract n-butanol extraction phase of Dendrobium huoshanense stems through three-step operations of silica gel column chromatography, acid solution and base precipitation and recrystallization; the structure of the compound is determined through nuclear magnetic resonance, high-resolution mass spectrometry and single crystal diffraction analysis; experiments show that the C17 sesquiterpene alkaloid can effectively inhibit the survival and proliferation of A549 lung cancer cells, has good anti-lung cancer activity, and can be used for preparing anti-lung cancer drugs.

The invention discloses a method for tracing organophosphorus pollution of a water body, which comprises the following steps of: investigating and surveying the water body, collecting a sample, analyzing mass spectrum, determining an enzymolysis rate coefficient, constructing an APCS-MLR model, and fundamentally correcting the model by utilizing the enzymolysis rate coefficient. The water body organophosphorus pollution traceability technology changes from molecular abundance analysis to ecological risk quantification, the goodness of fit between a model result and an on-site pollution source investigation result is greatly improved, and the problem of treatment resource mismatching caused by neglect of bio-availability difference in a traditional method is thoroughly solved. According to the method, the enzymolysis rate coefficient alpha is introduced, the ecological risk contribution proportion of organic phosphorus input by different pollution sources is accurately quantified, and the problem of source analysis distortion caused by neglecting of DOP degradation characteristics in a traditional method is solved.