6 results about "Hepcidin" patented technology

The application relates to a hepcidin chemiluminescence immunoassay kit and a non-diagnostic method for detecting hepcidin, the kit comprising a calibrator, a quality control, an integrated bifunctional antibody reagent, a magnetic particle reagent, a cleaning solution and a chemiluminescence substrate solution; the integrated bifunctional antibody reagent is a buffer containing HEP-specific antibodies covalently connected with fluorescein isothiocyanate and alkaline phosphatase through pH-sensitive connecting bonds; the magnetic particle reagent is a magnetic microsphere suspension coated with a goat anti-fluorescein isothiocyanate antibody; the cleaning solution is a buffer containing a surfactant composition, and the surfactant composition comprises nonionic surfactants, zwitterionic surfactants and high-molecular nonionic surfactants. The hepcidin chemiluminescence immunoassay kit has the effects of ultra-low background noise, ultra-high sensitivity, ultra-wide linear range and simplified operation of end users by means of the integrated bifunctional antibody reagent and the surfactant composition cleaning solution.

Aspects of the application provide siRNAs that target and reduce the expression of hemochromatosis type 2 (HFE2), compositions and methods of using the same to reduce serum hepcidin concentration and treat anemias of inflammation, iron-restricted anemias and / or conditions associated with anemia.

The disclosure provides compositions and methods for the treatment and / or prevention of sickle cell disease.

Aspects of the application provide hepcidin antagonists and methods of using the same in treating myelofibrosis and / or conditions associated with myelofibrosis.

This application discloses a functional composition, a conditioning agent, and its application in the preparation of a supplement for improving sub-health conditions. The functional composition comprises a first active ingredient and a second active ingredient. The first active ingredient includes red raspberry and carrot, and the second active ingredient includes one or more of artichoke extract and Fusarium oxysporin. The mass ratio of the first active ingredient to the second active ingredient is (1-10000):(1-10000). This application, through the formulation of active ingredients, promotes the body's absorption of iron through mechanisms such as intestinal iron absorption and / or regulation of hepcidin, thereby supplementing iron and significantly improving iron deficiency. Therefore, the functional composition provided by this application can be used to improve symptoms such as anemia caused by functional iron deficiency. Simultaneously, the functional composition also has beneficial effects such as regulating constitution, replenishing qi and blood, and improving sub-health conditions.