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296 results about "Linear range" patented technology

The linear range is that range of input or output values for which an electronic amplifier produces an output signal that is a direct, linear function of the input signal. When operating in the linear range, no clipping occurs. If an amplifier were perfectly linear, no distortion (harmonic distortion or intermodulation distortion) would occur (although random noise may still be introduced).

Integrated electrochemical biosensor capable of detecting double miRNAs with high sensitivity

The invention provides an integrated electrochemical biosensor capable of detecting double miRNA with high sensitivity, and the integrated electrochemical biosensor can simultaneously detect double miRNA markers with high sensitivity through self-assembly of a Y-shaped capture probe, preparation of an Au / TiO2-FTO array electrode, catalytic hairpin amplification (CHA) and construction of a micro-droplet chip electrochemical biosensor. The advantages of equalization of double-target miRNA capture probe sites, excellent electrode performance, reliable signal amplification, low sample consumption and the like are integrated, the linear range of miRNA21 and miRNA155 detection is 10 fM to 100 nM, and the detection limits are 5.00 fM and 5.17 fM respectively. By detecting the miRNA21 and miRNA155 double markers, the accuracy of breast cancer diagnosis is up to 98%, and the recognition sequences at the two ends of the Y stent probe are modified, so that the sensor can be used for diagnosing other miRNA marker related diseases. The integrated micro-droplet chip electrochemical biosensor constructed by the invention has a remarkable clinical diagnosis value and a prominent practical application prospect.
Owner:WUHAN UNIV OF SCI & TECH

Monolithic integrated multi-frequency CMUTs for wide-range pressure measurement

ActiveCN119573923AResonant frequencies do not overlapImprove pressure sensitivityTelevision system detailsImpedence networksCapacitive micromachined ultrasonic transducersMicromachinery
The invention relates to the field of pressure (0-200 kPa) detection, in particular to an MEMS integrated pressure sensing device or a monolithic integrated multi-frequency capacitive micromachined ultrasonic transducer (CMUTs) for wide-range pressure measurement. According to the monolithic integrated multi-frequency CMUTs, a first CMUTs, a second CMUTs and a third CMUTs are integrated on a chip; by adjusting the diaphragm thickness, cavity height and diaphragm radius of the first, second and third CMUT units and the pressure value in the cavity of the second CMUT unit, the first and second CMUT units work in a linear range of small deflection deformation, and the third CMUT unit works in a linear range of large deflection deformation. And the working ranges of the first CMUT unit, the second CMUT unit and the third CMUT unit form a continuous and complete measurement interval, and the resonant frequencies are not overlapped, so that the integrated pressure sensing device which can be used for 0-200 kPa full-pressure range measurement is realized.
Owner:ZHONGBEI UNIV

Fumonisins B1 fluorescent single particle intelligent detection method based on truncated aptamer-mediated nucleic acid cascade amplification

The invention discloses a fumonisins B1 fluorescent single particle intelligent detection method based on truncated aptamer mediated nucleic acid cascade amplification, and belongs to the field of biosensing detection. The invention successfully constructs a deep learning assisted fluorescent single-particle aptamer sensing detection method by taking a truncated aptamer with high affinity as a recognition element and AIE dye fluorescence coded microspheres with excellent luminescence property and good dispersibility as a signal marker, and can be used for high-sensitivity detection of FB1 in food. Compared with an existing reported FB1 detection method, the method has the advantages of being wide in linear range, high in sensitivity, low in sample consumption and the like, automatic, rapid and high-throughput recognition and counting detection of red particles in a fluorescence image can be achieved, and the analysis efficiency is greatly improved.
Owner:JIANGNAN UNIV

Device for expanding linear range of mass spectrum measurement

PendingCN121577728AMaterial analysis by electric/magnetic meansMass spectrometry measurementMass analyzer
The invention relates to the technical field of vacuum measurement, in particular to a device for expanding the linear range of mass spectrometry measurement, which comprises a gas transmission pipeline, an electromagnetic valve, a small hole and a mass spectrometer, and is characterized in that the front end of the gas transmission pipeline is used for allowing a sample to be measured to enter, and the rear end of the gas transmission pipeline is connected with the mass spectrometer; the middle part of the gas transmission pipeline is divided into three channels, namely a first gas transmission pipeline, a second gas transmission pipeline and a third gas transmission pipeline; the first electromagnetic valve and the first small hole are sequentially arranged on the first gas transmission pipeline, the second electromagnetic valve and the second small hole are sequentially arranged on the second gas transmission pipeline, and the third electromagnetic valve and the third small hole are sequentially arranged on the third gas transmission pipeline. According to the method, manual dilution or segmented sample injection is not needed, a wide concentration range can be covered by single analysis, more than 60% of time cost is saved, and measurement in a dynamic range of 106 is realized.
Owner:LANZHOU INST OF PHYSICS CHINESE ACADEMY OF SPACE TECH

Flexible piezoresistive sensor and preparation method and application thereof

The invention discloses a flexible piezoresistive sensor and a preparation method and application thereof, the flexible piezoresistive sensor comprises an upper layer flexible conductive member, the upper layer flexible conductive member comprises an upper layer flexible substrate and an upper layer conductive layer, one surface of the upper layer flexible substrate is provided with a microstructure formed by sand paper reverse molding, and the upper layer conductive layer is embedded in the surface of the microstructure; the lower-layer flexible conductive member comprises a lower-layer flexible substrate, a lower-layer conductive layer and an elastic conductive layer; the lower-layer flexible substrate is provided with an arc-shaped stripe array microstructure; the elastic conductive layer includes a polymer matrix and a conductive filler dispersed therein. Through the double-gradient design of the gradient conductivity and the gradient structure, the core contradiction that a traditional flexible piezoresistive sensor is difficult to consider high sensitivity and wide linear range at the same time is successfully solved by utilizing the deep coupling and synergistic effect of the conductivity gradient and the structure gradient, and synchronous improvement of the sensitivity and the linear range is realized.
Owner:HUNAN NORMAL UNIVERSITY

A trace hydrogen concentration sensing system based on TDLAS absorption spectroscopy

The present invention relates to the technical field of hydrogen concentration detection, and specifically discloses a trace hydrogen concentration sensing system based on TDLAS absorption spectroscopy, which is used to solve the problems of low detection sensitivity, narrow linear range, large system drift and dependence on external calibration in TDLAS hydrogen detection. The system comprises a laser emission module and a photoelectric detection module, wherein the laser emission module and the photoelectric detection module are connected via a dual-light path absorption module, the photoelectric detection module is connected to a harmonic extraction module, the harmonic extraction module is connected to a normalization processing module, and the normalization processing module is connected to a concentration inversion module. The present invention realizes high linearity, high sensitivity, and calibration-free concentration detection of hydrogen within 0.01% to 100% by constructing a symmetrical dual-light path structure, adopting a harmonic signal normalization and differential compensation algorithm, and combining a high-pressure reference gas cell with a segmented fitting model, thereby improving the trace hydrogen identification capability.
Owner:Hefei Institute of Technology

Label-free magnetic self-assembly nano-probe, construction method thereof and application of label-free magnetic self-assembly nano-probe in detection of PrPC protein

The invention provides a label-free magnetic self-assembly nanoprobe, a construction method thereof and application of the label-free magnetic self-assembly nanoprobe in detection of PrPC protein. The label-free magnetic self-assembly nanoprobe disclosed by the invention comprises a magnetic Fe3O4 / Fe2O3 (at) Au heteroplasmon nanorod array and a sulfhydrylation aptamer nucleic acid chain which is combined with the magnetic Fe3O4 / Fe2O3 (at) Au heteroplasmon nanorod array through an Au-S bond; a biosensor prepared from the label-free magnetic self-assembly nanoprobe is good in reproducibility and stability; the RSD value of multiple times of detection (intraday / day) is 1.55%; the storage time of multiple groups of sensors is 0-15 days, and the change of response signal values does not exceed 4%; the biosensor has a relatively low detection limit (1pg / mL), a relatively wide linear range (1 * 10 < pg / mL >-1 * 10 < 5 > pg / mL) and relatively good sensitivity, has very good application in detection of PrPC, and has very good practicability.
Owner:JIANGSU UNIV

Colorimetric-fluorescent bimodal nanoprobe for detecting cMyBP-C and micro-fluidic chip

The invention discloses a colorimetric-fluorescent bimodal nanoprobe for detecting cMyBP-C and a micro-fluidic chip, and belongs to the technical field of biomedical detection and in-vitro diagnosis. The colorimetric-fluorescent bimodal nanoprobe which takes UCNPs as a core and MOF as a shell and is loaded with horse radish peroxidase and a labeled antibody is prepared by providing a layer-by-layer self-assembly technology; the micro-fluidic chip is prepared according to the probe, the micro-fluidic chip can realize cMyBP-C colorimetric and fluorescence signal bimodal detection, and the technical problems of limited sensitivity, susceptibility to background interference, limited linear range, photobleaching phenomenon, signal instability and the like in single signal detection are solved.
Owner:SHANGHAI XINMIAO BIOLOGICAL TECHNOLOGY CO LTD

Flexible three-dimensional force touch sensor and preparation method thereof

The invention discloses a flexible three-dimensional force tactile sensor and a preparation method thereof, and belongs to the technical field of flexible tactile sensors. The flexible three-dimensional force tactile sensor solves the problem that when an existing flexible three-dimensional force tactile sensor senses tangential force, the wide linear range and the high sensitivity contradict each other, and the requirements that the sensitivity and the linear range can be flexibly adjusted and customized are met. According to the invention, the sensitive layer with transverse gradient change of modulus is constructed in a manner of sleeving and splicing materials with different moduli, so that the sensitivity of the sensitive layer is changed transversely, and the sensitive layer is used for regulating and controlling the change of the sensitivity and the linear range when the sensor detects tangential force; the non-uniformity of the surface stress distribution of the sensitive layer under the action of the tangential load is utilized by utilizing the sensitivity of the non-uniform transverse distribution of the sensitive layer, so that the tangential force sensing performance of the device is further improved, the method is also effective under the normal load, and the three-dimensional force sensor prepared by the method has high sensitivity and wide linear range, and can be applied to the field of sensor devices. The method is widely applied to the aspects of three-dimensional force measurement, direction control and the like.
Owner:CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES

Trace hydrogen concentration sensing system based on TDLAS absorption spectrum

The invention relates to the technical field of hydrogen concentration detection, and particularly discloses a TDLAS (tunable diode laser absorption spectroscopy) absorption spectrum-based trace hydrogen concentration sensing system, which is used for solving the problems of low detection sensitivity, narrow linear range, large system drift and dependence on external calibration in TDLAS hydrogen detection, and comprises a laser emission module and a photoelectric detection module, the laser emission module and the photoelectric detection module are connected through the dual-optical-path absorption module, the photoelectric detection module is connected with a harmonic extraction module, the harmonic extraction module is connected with a normalization processing module, and the normalization processing module is connected with a concentration inversion module; according to the device and the method, a symmetrical double-light-path structure is constructed, a harmonic signal normalization and differential compensation algorithm is adopted, and a high-pressure reference gas pool and a segmented fitting model are combined, so that high-linearity, high-sensitivity and calibration-free concentration detection of hydrogen within 0.01-100% is realized, and the hydrogen trace recognition capability is improved.
Owner:Hefei Institute of Technology

Miniature optical fiber end face integrated chimney-shaped structure reflection type surface plasma resonance biosensor for ultra-sensitive alpha fetoprotein detection

The invention provides a detection method of an end face integrated reflection type SPR optical fiber biosensor manufactured based on a 2PP technology. An experiment system mainly comprises a single-mode optical fiber, an optical fiber coupler, an SPR probe, a tungsten lamp light source, a sample pool, a spectrum analyzer and a computer. The method is characterized in that a volcanic three-dimensional microstructure is directly constructed on the end face of a single-mode fiber through a 2PP technology, a metal film with the thickness of about 50nm is deposited on the inner wall of the volcanic three-dimensional microstructure, and a stable and efficient SPR excitation structure is formed; the structural parameters are subjected to FDTD simulation optimization design, and have the characteristics of high quality factor and high sensitivity. The sensor can be used for AFP detection, the sensitivity reaches 0.684 nm / (ng / mL) within the linear range of 0-10 ng / mL, the normal and risk early warning concentration interval of human serum AFP is covered, and the sensor has good biological suitability and early hepatocellular carcinoma screening capacity; in addition, the probe structure is small in size, detection can be completed only by a few microliters of liquid to be detected, and the probe is suitable for a microfluidic platform with an extremely low sample size or a clinical sampling scene. Compared with the prior art, the device has the advantages of high structural integration, high sensitivity, low sample consumption, convenience in manufacturing, stability, reliability and the like.
Owner:NORTHEASTERN UNIV AT QINHUANGDAO

Functional polypeptide modified nano-composite magnetic bead, method for detecting beta-secretase by using same and application of functional polypeptide modified nano-composite magnetic bead

The invention belongs to the technical field of preparation, analysis and detection of nano composite materials, and particularly relates to a functional polypeptide modified nano composite magnetic bead, a method for detecting beta-secretase by using the functional polypeptide modified nano composite magnetic bead and application of the functional polypeptide modified nano composite magnetic bead to the detection of beta-secretase. The surface of a shell layer is connected with an ethylenediamine tetraacetic acid modification layer, metal ions Co < 2 + > or Ni < 2 + > are chelated on the modification layer, functional polypeptide marked by fluorescein Cy5 and the metal ions Co < 2 + > or Ni < 2 + > are coupled and loaded on the surface of a nano composite magnetic bead, and the nano composite magnetic bead is used for detecting beta-secretase. The kit has the advantages of high sensitivity, strong anti-interference capability, small background signal and capability of being magnetically separated and repeatedly used, the detection linear range is 2.5 ng / mL-800ng / mL, the detection limit is 0.62 ng / mL, and the kit has important application potential in AD early diagnosis and treatment and drug research and development.
Owner:INST OF SENSOR TECH GANSU ACAD OF SCI

Photometric device, sample analyzer and sample detection method

The invention provides a photometric device, a sample analyzer and a sample detection method. The sample analyzer comprises a loading device, a reaction device; a detection device; the controller obtains the photon counting result of each detection assembly and obtains a target counting result according to the photon counting results of the at least two detection assemblies, the linear ranges of the at least two detection assemblies are at least partially not overlapped, the photoelectric detectors of the at least two detection assemblies receive optical signals emitted by the reaction liquid in the same sample container, and the target counting result is obtained according to the optical signals. The photon counting result obtained by final detection can be prevented from being influenced by the pulse accumulation effect, so that the upper limit of the linear photometric range of the chemical reaction is improved, and the detection accuracy and the detection efficiency of a relatively strong light section of the chemical reaction are improved.
Owner:SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD

Preparation method of near-infrared PET fluorescent probe for AFP detection

PendingCN121227343AMaterial nanotechnologyNanoopticsPhotoinduced electron transferCarboxyl radical
The invention provides a method for specifically detecting AFP based on a photoinduced electron transfer effect between blood orange RCDots and an AFP-aptamer, and the preparation and AFP detection principles of a near-infrared PET fluorescent probe for AFP detection are as follows: the RCDots with rich carboxyl groups on the surface can strongly adsorb ssDNA to the surface of the RCDots through pi-pi stacking interaction; and a formed RCDots / AFP-aptamer compound is subjected to a photo-induced electron transfer effect, so that the fluorescence of the RCDots is remarkably quenched. However, the affinity between the AFP and the AFP-aptamer is stronger than pi-pi stacking interaction, so that ssDNA is separated from the surface of the RCDots, the light-induced electron transfer effect disappears, the fluorescence of the RCDots is recovered, and the fluorescence intensity is changed along with the change of the concentration of the AFP, so that the concentration of the AFP is detected with one kind of specificity. The detection method is simple, has the characteristics of wide detection linear range, low detection limit, good specificity and the like, and can be widely applied to clinical detection of liver cancer markers.
Owner:HEZHOU UNIV

Piezoelectric-piezoresistive collaborative mechanism-based sensor array and preparation method and application thereof

The invention relates to a piezoelectric-piezoresistive collaborative mechanism-based sensor array and a preparation method and application thereof. The sensor array comprises a flexible packaging substrate layer, a piezoelectric layer, a piezoelectric layer and a piezoelectric layer which are sequentially integrated from bottom to top, the bottom electrode layer is composed of a stretchable silver electrode array subjected to silk-screen printing and serves as a lower electrode of the piezoelectric sensor; the piezoelectric functional layer is composed of a lead zirconate titanate-glass fiber composite film, and the piezoelectric functional layer is subjected to corona polarization treatment; the piezoresistive sensing layer is formed by spraying a polyvinylpyrrolidone modified carbon material dispersion liquid, the piezoresistive sensing layer is used as an upper electrode of the piezoelectric sensor, the piezoresistive sensing layer is directly deposited on the surface of the piezoelectric functional layer, and the piezoresistive sensing layer and the piezoelectric functional layer pass through a common electrode; and packaging a protection layer on the top layer. Compared with the prior art, the method has the advantages of high sensitivity, wide linear range and multi-parameter synchronous detection capability, high-resolution real-time deformation identification can be realized, and key technical support is provided for high-precision sensing application such as profile inversion.
Owner:SHANGHAI JIAOTONG UNIV

Photoelectrochemical sensor based on wide-spectrum double photoelectrodes and preparation method and application of photoelectrochemical sensor

The invention provides a wide-spectrum dual-photoelectrode-based photoelectrochemical sensor and a preparation method and application thereof, and belongs to the technical field of photoelectrochemical sensors. According to the photoelectrochemical sensor provided by the invention, a BCN / ITO electrode is used as a photoanode, a CuInS2 / ITO electrode is used as a photocathode, BCN is Bi2S3 / C3N4, and ITO is indium tin oxide. The sensor is used for detecting enrofloxacin and ciprofloxacin pollution. According to the present invention, the surface is modified with the aptamer having the specific recognition function, the specific binding effect of the aptamer with the enrofloxacin and the ciprofloxacin is utilized to form the complex of the aptamer and the target object, and the influence of the caused steric hindrance effect on the photoelectric signal and the dual-channel strategy are utilized to achieve the simultaneous detection of the residual marker; the linear ranges for detecting enrofloxacin and ciprofloxacin are 0.1 nM to 1 mu M and 50 pM to 0.5 mu M respectively, the detection limits are 24 pM and 15.5 pM respectively, and the method is successfully applied to simultaneous detection of residual markers in water. The method has the advantages of greenness, environmental protection, wide detection range, high sensitivity, good selectivity and high stability.
Owner:JIANGSU UNIV

Dual-signal-amplification lanthanide oxide electrochemiluminescence aptamer sensor for detecting acetamiprid, and preparation method and application of dual-signal-amplification lanthanide oxide electrochemiluminescence aptamer sensor

The invention relates to a lanthanide oxide electrochemiluminescence aptamer sensor with dual signal amplification for detecting acetamiprid as well as a preparation method and application of the lanthanide oxide electrochemiluminescence aptamer sensor. According to the sensor, terbium-doped europium oxide (Eu2O3: Tb < 3 + >) modified by gold nanoparticles (Au NPs) is used as a luminous body, and the electrochemical luminescence performance can be remarkably improved through multiple mechanisms: on one hand, the Au NPs can effectively promote generation of more sulfate free radicals; on the other hand, the surface defect passivation effect and the efficient synergistic effect of energy transfer jointly achieve effective amplification of signals. In addition, the wool ball-shaped Ag NPs is used as a plasma resonance signal amplification source, so that the ECL intensity of the sensor is further enhanced. The prepared electrochemical luminescence sensor with the dual signal amplification effect is used for detecting acetamiprid (ACE), has a wide linear range and a low detection limit, and has a wide application prospect in detection of acetamiprid residues in a water environment.
Owner:CHANGZHOU NUOJUN ELECTRONIC TECHNOLOGY CO LTD

Superconducting quantum interference device based on Josephson junction and preparation method thereof

According to the superconducting quantum interference device based on the Josephson junction and the preparation method of the superconducting quantum interference device based on the Josephson junction, the manufacturing process of the Josephson junction is improved, and an organic cleaning process is added in the photoresist stripping process, so that the side wall formed by continuous stacking can be removed, the quality of a subsequently deposited film is improved, and the performance of the superconducting quantum interference device is improved. The SQUID output curve is not easy to generate resonance, and the yield of the SQUID batch preparation process is improved; on the basis of a traditional SQUID, each Josephson junction is additionally connected in series or in parallel with one Josephson junction to form the SQUID with four Josephson junctions, so that a larger output voltage modulation depth is obtained, the SQUID has higher sensitivity, lower noise and a larger linear range, a circuit is not prone to losing lock, and the SQUID has the advantages of being simple in structure, low in cost and high in reliability. A lengthy offset line does not need to be added, the problems of magnetic flux crosstalk, poor magnetic flux coherence and the like do not need to be worried about, and the layout structure design is simpler and more convenient.
Owner:SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI

Photoelectrochemical-colorimetric dual-mode biosensor and application thereof in miRNA detection

The invention belongs to the technical field of biological analysis and detection, and particularly relates to a photoelectrochemical-colorimetric dual-mode biosensor and application thereof in miRNA detection. According to the biosensor prepared by the invention, the bifunctional CuO-Cu2O nanoflower and the three-dimensional network g-C3N4 / AuNPs electrode are integrated, and an enzyme-assisted strand displacement signal amplification mechanism is combined, so that dual-mode collaborative detection of a target miRNA-21 is realized: in a photoelectrochemical mode, the detection limit reaches 0.35 fM (the linear range is 1 fM to 10 fM), and response is performed based on photocurrent polarity reversal; the colorimetric mode is as follows: the detection limit is 3.9 fM (the linear range is 10 fM to 10 nM), and TMB (Tetramethylbenzidine) color development visualization analysis is carried out. Single-mode interference is effectively eliminated through double-signal independent output and cross validation, and the method is suitable for high-reliability detection of trace miRNA (such as a breast cancer marker miRNA-21) in complex samples such as serum. According to the invention, the defects of insufficient sensitivity (pM level), poor anti-interference performance and high platform complexity in the prior art are overcome, and an efficient tool is provided for early diagnosis of cancers.
Owner:WEIFANG UNIVERSITY

Ag + (at) Eu MOF / HOF-based resonance energy transfer electrochemical luminescence aptamer sensor and application thereof in acetamiprid detection

The invention belongs to an electrochemiluminescence aptamer sensor, and relates to a resonance energy transfer electrochemiluminescence aptamer sensor based on Ag < + > (at) Eu MOF / HOF and application thereof in acetamiprid detection. A rod-like hydrogen bond organic framework is used as a precursor, and lanthanide Eu < 3 + > is doped. The electrochemical luminescence aptamer sensor for resonance energy transfer is prepared by taking Ag < + > as a co-reactant accelerant, synthesizing Ag < + > (at) Eu MOF / HOF as an energy donor of a resonance energy transfer system and taking leaf-shaped CdS (at) Au-cDNA as an energy receptor. The sensor is used for ACE detection, and has a wide linear range and a low detection limit. The prepared novel Ag < + >-coated Eu MOF / HOF electrochemical luminescence material is applied to electrochemical luminescence detection for the first time and used for detecting acetamiprid residues in water, and an effective and convenient strategy is developed for analysis and detection of pollutants in a water environment.
Owner:CHANGZHOU UNIV

Satellite platform-based strabismus mode ground interference source positioning method and system, storage medium and electronic equipment

The invention discloses a strabismus mode ground interference source positioning method and system based on a satellite platform, a storage medium and electronic equipment, and the method comprises the following steps: firstly, carrying out the range pulse compression of a received interference signal according to the related parameters estimated by the prior information of an orbit and the time-frequency relation; constructing a matched filter, realizing linear range migration correction, and eliminating a first-order component of range migration in a range frequency domain-azimuth time domain; a CTF search algorithm is used, and under different search distances, distance direction search is achieved through a cooperation mechanism of global search and step length constraint local optimization; constructing matched filters at different distances to realize quadratic term range migration correction, and eliminating a range migration quadratic term in a two-dimensional frequency domain; azimuth distance compression is carried out at different distances, so that signals are focused; and obtaining a two-dimensional positioning position opposite to the interference source through coordinate transformation. According to the invention, the problem of signal defocusing caused by the distance-orientation strong coupling effect is solved in the squint mode, and the interference source positioning precision is significantly improved.
Owner:HENAN UNIVERSITY

Anti-fouling electrochemical sensor based on double network hydrogel and its preparation and application

The present invention provides an anti-pollution electrochemical sensor based on a double network hydrogel and its preparation and application, belonging to the technical field of chemical sensors. The present invention first prepares a micron-sized chitosan hydrogel, then adds an aptamer chain and a DNA chain, adds a nano-sized DNA hydrogel structure to the micron-sized chitosan hydrogel, and finally constructs an anti-pollution electrochemical sensor based on a double network hydrogel with an ultra-large specific surface area. The experimental results show that the anti-pollution electrochemical sensor based on the double network hydrogel constructed by the present invention has a wide linear range, a low detection limit and good selectivity for ATP detection, and especially has excellent accuracy, which can ensure that the electrochemical sensor is not interfered in a complex serum environment.
Owner:QINGDAO UNIV OF SCI & TECH

Construction method of aptamer modified photonic crystal sensor for visual detection of oxytetracycline

The invention discloses a construction method of an aptamer modified photonic crystal sensor for visually detecting oxytetracycline, and belongs to the technical field of sensing. In the invention, a photonic crystal array obtained by a vertical evaporation self-assembly method is combined with polyacrylamide hydrogel to form the photonic crystal hydrogel membrane material. Gold nanoparticles serve as a bridge, one side of each gold nanoparticle is connected with an amide framework of the hydrogel through chelation, the other side of each gold nanoparticle is connected with the oxytetracycline aptamer through covalent bonding, and the aptamer modified photonic crystal sensor is constructed. The oxytetracycline aptamer and oxytetracycline are highly selectively combined through pi-pi stacking and hydrogen bonds, so that the hydrogel swells, the lattice spacing of the photonic crystal is increased, a reflected signal and a structural color are subjected to red shift, and high-selectivity detection of the oxytetracycline is realized. The rapid detection requirements in the fields of food safety, environment monitoring, biological medicine and the like are met. The linear range of oxytetracycline detection is 0.1 mu g / mL-80 mu g / mL, and the lowest detection limit is 0.033 mu g / mL.
Owner:QINGDAO UNIV OF SCI & TECH

Magnetoresistive element, angle sensor and electronic equipment

The invention relates to the technical field of angle measurement, and discloses a magnetoresistive element, an angle sensor and electronic equipment. The magnetoresistive element comprises a plurality of magnetoresistive sub-elements, and the magnetoresistive sub-elements are used for inducing in-plane magnetic field components acting on the magnetoresistive sub-elements in a magnetic field generated by the magnetic field source and outputting a linearly changing first signal in response to the in-plane magnetic field components within a preset magnetic field range; the magnetoresistive sub-element comprises a plurality of magnetic tunnel junctions, and sensing layers in the magnetic tunnel junctions are provided with closed vortex magnetization patterns; and the plurality of magnetic orbital transfer elements are positioned around the magnetic resistance sub-elements and are used for adjusting the magnetic field distribution of the magnetic field generated by the magnetic field source around the magnetic resistance sub-elements, so that the first signal is related to the rotation angle of the magnetic field source. The magnetoresistive element can measure the angle information of the magnetic field source in a linear interval, avoids the problem that a strong magnetic field generated by the magnetic field source causes fine offset of the reference layer and further affects the angle measurement precision, and has the advantages of being simple in structure and easy to implement.
Owner:ZHUHAI MULTI-INNOVATION TECHNOLOGY CO LTD

Construction and application of biosensor based on efficient antifouling interface and dual signal amplification

The invention discloses construction and application of a biosensor based on an efficient antifouling interface and dual signal amplification, and belongs to the technical fields of optical / electric analytical chemistry, biosensing and material science. According to the invention, the electrode interface is modified with polyaniline doped with polytannic acid as an antifouling film, so that non-specific adsorption of interfering biomolecules in a complex medium is resisted; euTb-MOF is prepared as an efficient luminous body, Tb < 3 + > can transfer energy of Tb < 3 + > and ligand to Eu < 3 + >, and effective signal self-enhancement is realized; according to the EuTb-MOF, the reduction of S2O8 < 2-> is promoted by utilizing the reversible conversion of valence states of Co < 2 + > / Co < 3 + > and Fe < 2 + > / Fe < 3 + > and the synergistic catalysis of Ag NPs, so that the electrochemical luminescence signal of the EuTb-MOF is further improved. Based on the above strategy, the constructed biosensor has high detection sensitivity and precision and long service life, the linear range is 10 fM to 100 nM, and the detection limit is as low as 3.62 fM.
Owner:QINGDAO UNIV OF SCI & TECH

Underwater CSK-OFDM modulation and detection method based on LED linear constraint

The invention discloses an underwater CSK-OFDM modulation and detection method based on LED linear constraint, and the method comprises the steps: enabling a transmitter to map a data bit stream of a constellation diagram into a complex symbol stream, converting the complex symbol stream into a real number time domain sequence through an ACO-OFDM module, carrying out the LED amplitude limiting of the time domain sequence, and obtaining a time domain clipping sequence; transmitting the time domain clipping sequence in a UOWC channel through a corresponding LED, introducing symbol timing deviation and amplitude limiting noise into a frequency domain by a receiver, and processing the time domain clipping sequence by using an ACO-OFDM module again to obtain a received signal; under the maximum expectation framework, the probability from each alternative constellation diagram is calculated, symbol timing deviation and additive white Gaussian noise variance are estimated, a globally optimal solution is obtained, and a constellation diagram recognition result is output through maximum likelihood demodulation. According to the method, the linear range constraint of the LED and the complex environment under the UOWC scene are comprehensively considered.
Owner:SUN YAT SEN UNIV

Molecularly imprinted electrochemical-photoelectrochemical dual-mode sensor for detecting tetracycline as well as preparation method and application of molecularly imprinted electrochemical-photoelectrochemical dual-mode sensor

The invention provides a molecularly imprinted electrochemical-photoelectrochemical dual-mode sensor for detecting tetracycline as well as a preparation method and application of the molecularly imprinted electrochemical-photoelectrochemical dual-mode sensor, and relates to the technical field of detection. According to the molecularly imprinted electrochemical-photoelectrochemical dual-mode sensor for detecting tetracycline, provided by the invention, the tetracycline is accurately detected by utilizing a quenching effect of a steric hindrance effect caused by specific binding of tetracycline and an imprinted cavity on electrochemical and photoelectric signals, and the molecularly imprinted electrochemical-photoelectrochemical dual-mode sensor has the advantages of wide detection range, high sensitivity and high accuracy. Wherein the electrochemical detection linear range is 5.010 <-14 > to 1.010 <-9 > mol / L, and the detection limit is 2.110 to 14 mol / L; the linear range of photoelectrochemical detection is 5.010 <-12 >-5.010 <-6 > mol / L, the detection limit is 2.710 <-13 > mol / L, and the method is successfully used for detecting the content of tetracycline in water around livestock and poultry farms and has good analysis performance.
Owner:JIANGSU UNIV

Three-dimensional magnetic sensor based on abnormal Hall effect

PendingCN120475892AHeterojunctionRemanence
The invention discloses a three-dimensional magnetic sensor based on an abnormal Hall effect, and belongs to the technical field of spin electron sensors. The three-dimensional magnetic sensor comprises a substrate, an AHE thin film material layer with PMA, a rare earth material layer, a protective layer and a metal electrode layer which are sequentially arranged from bottom to top, the AHE thin film material layer with PMA is of a Pt / Co / Pt multi-layer thin film heterostructure, and the rare earth material layer is Dy. According to the three-dimensional magnetic sensor based on the abnormal Hall effect provided by the invention, a rare earth material Dy layer with a proper thickness grows on a Pt / Co / Pt structure, Co and Dy form antiferromagnetic coupling based on RKKY interaction, residual magnetism adjustment driving current and power consumption are reduced, so that magnetic hysteresis is reduced, and the driving current and power consumption are correspondingly reduced; and the existence of RKKY interaction does not change the multilayer film PMA, so that the linear range is kept unchanged.
Owner:UNIV OF ELECTRONICS SCI & TECH OF CHINA

Protective circuit for a device or power circuit breaker and method for this

The invention relates to a protective circuit (1) for a device or power circuit breaker comprising, • an active controllable component (B1) which can be controlled in a linear range, • at least one measuring device (S P , S U , S i , S Uin , S Uout ) to determine a power output that is implemented in the actively controllable component (B1), • a processing unit (uC), • where an energy equivalent can be determined based on the specified power and a time between two measurements, • where time-separated energy equivalents are combined by the processing unit (uC), • where at least two time-related limit values ​​(G t1 , G t2 , ... G tn ) are planned, • where, upon reaching and / or exceeding a limit value (G t1 , G t2 , ... G tn) by an energy equivalent or the combined energy equivalents in a limit value (G t1 , G t2 , ... G tn ) assigned time the active controllable component (B1) is controlled by the processing unit (uC) in such a way that the current flow through. Furthermore, the invention relates to a method.
Owner:PHOENIX CONTACT GMBH & CO KG

Perchlorate selective electrode based on electron / ion dual-channel material and preparation method of perchlorate selective electrode

The invention discloses a perchlorate selective electrode based on an electron / ion dual-channel material and a preparation method of the perchlorate selective electrode. The electron / ion dual-channel material is synthesized by polymerizing part of polypyrrole on the surface of Mxene and introducing long-chain alkyl substituted quaternary ammonium salt, and the material combines the dual-channel characteristics of ion enrichment and conductivity, and can significantly improve the perchlorate detection capability. Experimental results show that a perchlorate selective electrode made of the dual-channel material shows extremely high selectivity and ultra-low detection limit recognition on perchlorate, the lowest detection limit can reach 12.4 mu g / L, meanwhile, the response time is extremely short (-4s), and therefore sensitive and rapid detection on the perchlorate under the complex water body condition can be achieved. The perchlorate selective electrode provided by the invention has the characteristics of wide detection linear range, low detection limit, strong anti-interference capability, simplicity in operation, high efficiency, rapidness, low cost and the like when being used for detecting perchlorate. Therefore, the method has a wide application prospect.
Owner:HUNAN UNIV +1