23 results about "Binding effect" patented technology

This utility model discloses a 3D-printed outdoor shoe, belonging to the field of shoe technology. The shoe includes an upper and a sole. The sole includes a midsole and an outsole. The upper is fixedly connected to the midsole, and the midsole is fixedly connected to the outsole on the opposite side of the upper. Several loops are provided on both sides of the upper, passing through the upper and fixedly connected to the midsole. Shoelaces are threaded through the loops, alternately passing through the loops on both sides. The two ends of the shoelaces emerge from the loops near the shoe opening. The shoelaces are equipped with fastening elements for tightening. This utility model shifts the main stress point of the shoelaces from the upper to the midsole. The combination of the loops and shoelaces creates a binding effect on the foot, thus fixing the foot inside the shoe. This method reduces deformation of the upper and the need for elasticity, allowing for better adaptation to the 3D-printed upper.

An antibody-conjugated liposome, particularly a nanoparticle. The surface of the nanoparticle contains antibodies. The number of the antibodies is 5-60, preferably 5-50, and more preferably 5-40. The nanoparticle, for example, a liposome, can more effectively exert a therapeutic effect on tumor and improve multidrug resistance of tumor, thereby overcoming the technical prejudice that it is commonly considered that the more antibodies on a surface of a liposome, the better the target cell binding effect, and laying a foundation for further clinical development.An antibody-conjugated liposome, particularly a nanoparticle, the surface of which contains antibodies, and the number of the antibodies is 5-60, preferably 5-50, and more preferably 5-40. The nanoparticle, such as a liposome, can more effectively exert a therapeutic effect on tumors and reduce the multidrug resistance of tumors. This overcomes the generally accepted technical bias that more antibodies on the surface of a liposome lead to better binding with target cells, thereby laying the foundation for further clinical development.

The application discloses a micro-bubble generating method and device. The micro-bubble generating method and device utilize high-speed liquid jet impact on gas and the binding effect of a rotary body structure on bubbles, so that the bubbles are frequently sheared and broken by the liquid jet to generate a large amount of micro-bubbles. Meanwhile, the wall jet formed by the high-speed liquid jet impact on a flat plate promotes the uniform dispersion of the micro-bubbles. The micro-bubble generating method and device have the advantages of simple structure, good micro-bubble generating effect, large gas processing capacity, low energy consumption and good bubble dispersion and mixing effect.

The invention discloses a binding device and method for thickened archive documents, the binding device comprises an outer cylinder shell (2) used for supporting the inner side face of the thickened archive documents, a pressing seat (4) arranged in the outer cylinder shell (2), and an inner cylinder shell (5) arranged between the pressing seat (4) and the outer cylinder shell (2), one side face of the thickened archive documents is supported through the outer cylinder shell (2), and the inner cylinder shell (5) is arranged between the pressing seat (4) and the outer cylinder shell (2). By means of an inner barrel shell (5), the binding operation space of a penetrating needle and a binding line on the thickened archive document is set, the thickened archive document in the binding state is placed in an arc-shaped gap, and the binding efficiency is improved. The technical problem that due to the fact that a penetrating needle is used, the area of a clamping point of the thickened archive document is limited by a clamp, and the thickened archive document can be misplaced under the action of crossing acting force of the penetrating needle is solved, and therefore the binding effect of the thickened archive document is improved.

The application relates to the technical field of batteries, and discloses an electrode assembly and a manufacturing tool thereof. The electrode assembly comprises an electrode assembly body, and a binding belt is sleeved on the surface of the electrode assembly body. The width of the binding belt is smaller than the height of the electrode assembly body, and the binding belt is located between the two end surfaces of the electrode assembly body. Based on the above-mentioned electrode assembly, the binding belt has a binding effect on the electrode assembly body by being sleeved on the surface of the electrode assembly body, so that the electrode assembly can be prevented from being wrinkled due to the influence of tension, and the electrode assembly can also be prevented from being wrinkled due to deformation in the process of soaking, so that the quality of the electrode assembly is ensured. Meanwhile, since the width of the binding belt is smaller than the height of the electrode assembly body, and the binding belt is located between the two end surfaces of the electrode assembly body, the binding belt can be prevented from affecting lug welding and subsequent electrode assembly soaking, so that the binding belt does not affect the normal function of the electrode assembly.

The utility model discloses an automatic bookbinding machine, which belongs to the technical field of bookbinding, and comprises a bookbinding device, a positioning device and a clamping and pushing device, the positioning device used for positioning a product before bookbinding and the clamping and pushing device used for pushing the product into a bookbinding station are arranged on the bookbinding device; the clamping and pushing device comprises a pushing assembly used for pushing the products, a follow-up clamping assembly used for limiting and clamping the products and an adjusting assembly assisting in adjusting the follow-up clamping assembly, the pushing assembly and the adjusting assembly are installed on the binding device, and the follow-up clamping assembly is connected with the pushing assembly and the adjusting assembly. By means of the mode, by arranging the positioning device, products are aligned in all directions during binding, the binding effect is good, by arranging the pushing assembly and the follow-up clamping assembly, the products can be clamped and fixed while being pushed to the binding station, and the situation that the binding effect is poor due to displacement in the pushing process is avoided.

The invention discloses a rapid hemostasis bandaging device for emergency treatment wounds, relates to the technical field of hemostasis bandaging instruments, and provides the following scheme that the rapid hemostasis bandaging device comprises a first-aid backpack, the front side of the first-aid backpack is connected with a bandaging disinfection mechanism, and the bottom surface of the bandaging disinfection mechanism is fixedly connected with a bandaging forceps mechanism. According to the scheme, the binding forceps mechanism and the binding and disinfecting mechanism are cooperatively matched, flexible opening and closing and stable fixing of the semi-annular grooves are achieved through hinging of forceps handles and the design of the torsional spring, and limb placement and operation are facilitated. The arrangement of the electromagnet is ingenious, the semi-annular strips are tightly connected when the semi-annular grooves are closed, the stability of the device in the binding process is ensured, and the binding effect is improved. The servo motor drives the semi-ring-shaped strip to do circular motion and is matched with the hemostatic bandage which is adhered to the limb in advance, so that the wound can be quickly and uniformly bound, and the time is saved. Atomizing nozzles are distributed in an annular array mode, wounds can be completely covered, and disinfectant is effectively sprayed for disinfection.

The invention relates to the technical field of biology, in particular to application of multi-ligand glycan-4 to regulation and control of intercellular function of macrophages and renal fibrosis. According to the application, the inhibitor for inhibiting the binding effect of the binding areas between the multi-ligand glycan-4 and the phagocytosis and cell movement protein 1 is used for preparing the accelerant for promoting the interburial function of the macrophages. The application is based on earlier-stage research finds that the platelet reaction protein 1 is combined with a multi-ligand glycan-4 receptor on the surface of macrophages, meanwhile, the platelet reaction protein 1 can promote combination between the multi-ligand glycan-4 and phagocytosis and cell movement protein 1, and the interburial function of the macrophages is inhibited. And an animal model of knocking down the multi-ligand glycan-4 can delay the progress of renal fibrosis. Therefore, the multi-ligand glycan-4 can regulate and control the cellular burial function of the macrophages and delay the process of renal fibrosis at the same time, and the blank that the cellular burial function of the targeted macrophages is applied to renal fibrosis treatment in the prior art is filled.

The invention discloses a buckle-free hairy crab binding machine, and relates to the technical field of binding machines. Comprising a machine body, an arc-shaped cover is fixedly installed on the machine body, a containing block is arranged in the arc-shaped cover, and a rope winding groove is formed in the containing block; an L-shaped frame plate is fixedly installed on the arc-shaped cover, an adjusting assembly is arranged on the L-shaped frame plate, a connecting transverse rod is arranged on the adjusting assembly, and a U-shaped frame plate is fixedly installed at the end of the connecting transverse rod. According to the crab binding machine, through effective cooperation of the adjusting assembly and the overturning assembly, it is ensured that crabs can be stably fixed in the containing block, potential safety hazards caused by manual pressing of workers are avoided, meanwhile, the crabs are prevented from being injured, the crabs can be automatically taken out of the containing block through the design of the lifting assembly, taking and placing work of operators is greatly facilitated, and the working efficiency is improved. And meanwhile, the position-adjustable wire feeding pipe is utilized to ensure that the tightness of the binding rope is moderate, so that the binding effect is improved, and the use effect of the binding machine is effectively improved.

This application discloses an immunoassay kit, its preparation method, and its application. The immunoassay kit includes a small peptide-coated solid-phase carrier, a bispecific antibody, and a labeled detection antibody. The bispecific antibody includes an anti-small peptide antibody and a linked capture antibody. The anti-small peptide antibody specifically binds to the small peptide, and both the capture antibody and the labeled detection antibody specifically bind to the target analyte and have different antigen recognition epitopes. The highly specific binding of the small peptide to the anti-small peptide antibody achieves efficient immobilization of the bispecific antibody, significantly improving antibody immobilization density and activity retention compared to traditional detection methods. The targeted binding effect of the bispecific antibody amplifies the detection signal while avoiding competitive interference from endogenous biotin, achieving highly sensitive and interference-resistant immunoassay.

The application discloses a well site pipe cable binding device and a binding control method. It relates to the technical field of in-situ leaching uranium well site cable and pipe material binding technology, and comprises a pipe cable embracing mechanism and a binding piece conveying mechanism connected with the end of the pipe cable embracing mechanism. The pipe cable is arranged in the pipe cable embracing mechanism. A driving mechanism is arranged on the pipe cable embracing mechanism. The binding piece conveying mechanism is used for driving the binding piece to move around the pipe cable in the circumferential direction under the driving of the driving mechanism, so that the pipe cable is fixed and bound. The application can improve the pipe cable binding efficiency and ensure the pipe cable binding effect.

This utility model discloses a feeder for a perfect binding machine. It relates to the field of perfect binding machine technology and includes a fixed assembly. The fixed assembly contains a moving assembly, which includes a moving base. The moving base has a fixed groove. Moving side plate assemblies and fixed side plate assemblies are respectively located on both sides of the fixed groove. The fixed side plate assembly includes a fixed clamping plate and a second telescopic rod. The fixed clamping plate is fixedly connected to one side of the fixed groove. A second limiting groove is provided on one side of the fixed clamping plate. A second lifting bar is slidably connected inside the second limiting groove. A second guide plate is fixedly installed on the top of the second lifting bar. A lifting block is fixedly installed at the output end of the second telescopic rod. This utility model allows for adjustment of the height of the moving side plate assembly and the fixed side plate assembly, enabling the device to clamp and fix pages of different widths, improving the perfect binding effect and possessing high practical value.

The application discloses a DNA nano antisense drug targeting microRNA, a preparation method and application thereof. The DNA nano antisense drug comprises a DNA nanostructure as a carrier, antisense peptide nucleic acid and selected aptamer, the DNA nanostructure wraps the antisense peptide nucleic acid, and exposes the selected aptamer, the antisense peptide nucleic acid is connected to the 3' end of a staple chain constituting the DNA nanostructure, and the selected aptamer is modified to the 5' end extended from another staple chain constituting the DNA nanostructure, and the antisense peptide nucleic acid can specifically recognize target microRNA in tumor cells. The DNA nano antisense drug has the advantages of simple preparation process, low price and harmless metabolic products, has strong specific binding effect on target microRNA and can promote cell apoptosis, and has great application value in the field of anticancer drug preparation.

The utility model relates to a handcart for battery transportation, include: support, at least one mounting piece and bandage, be provided with support piece on the support, and mounting piece is slidably arranged on the support piece, in use, the bandage is installed between the mounting plate and the mounting ring, and the mounting plate and the mounting ring can cooperate with each other to limit the position of the bandage, after placing the goods needing transportation on the support piece, according to the type and the size of the goods, the position of the mounting plate is slid, the position of the bandage can be adjusted flexibly, and then the bandage can be pulled to tighten the goods. Through the above setting, the position of the binding can be flexibly selected to realize the best binding effect, and then the stability during transportation is improved.

This invention belongs to the field of microbial fertilizer and bioengineering technology, and discloses a modified graphene-immobilized functional strain and its applications. It includes optimizing the selection and preparation of the culture medium, strain activation and modified graphene immobilization, and identification of the binding effect. This invention achieves dual cost reduction, is suitable for industrial production, synergistically improves immobilization efficiency and strain stability, dually enhances strain activity and metabolic function, is environmentally friendly, and expands application scenarios.

The invention relates to the technical field of medical equipment, in particular to an intelligent binding device for a dysphoria child patient in the department of pediatrics, which comprises a placement frame, and a first equipment shell and a second equipment shell are respectively arranged on two sides of the placement frame; a first chest and abdomen binding belt and a second chest and abdomen binding belt are arranged on the first equipment shell and the second equipment shell correspondingly, binding range adjusting assemblies are arranged on the first equipment shell and the second equipment shell correspondingly, an air bag adjusting assembly is arranged on the inner side of the first chest and abdomen binding belt, and a tension collecting assembly is arranged on the second chest and abdomen binding belt; according to the device, dysphoria tension data of a child patient is collected in real time, self-adaptive adjustment of binding tightness is achieved based on the tension data, meanwhile, the two chest and abdomen binding belts are adopted to be interwoven, the binding pressure of the child patient is dispersed through an annular wrapping type structure, and the binding effect of the child patient is improved. The defect that an existing restraining device is difficult to adapt to dysphoria fluctuation of a child patient is overcome.

The invention relates to a composite material for adsorbing heavy metal thallium and a preparation method thereof, which are applied to the technical field of environmental functional materials. The composite material comprises a porous carrier, an organic ligand which is grafted on the porous carrier and has a specific binding effect on Tl < + >, and loaded metal sulfide nanoparticles. The preparation method is characterized in that the surface of the carrier is modified with a bifunctional coupling agent, a first functional group of the coupling agent is covalently bonded with an organic ligand, and a second functional group of the coupling agent is an active group capable of being coordinated with metal ions; the metal sulfide nanoparticles are generated in situ under the guidance of coordination of active groups. The preparation method comprises the steps of carrier coupling, capture unit grafting, metal ion coordination and enrichment, sulfur source introduction, selective in-situ vulcanization and the like. According to the method, high-selectivity adsorption and deep in-situ mineralization solidification of trace thallium ions in water are achieved, the synergistic effect is remarkable, secondary pollution can be effectively eradicated, the condition is mild, and the method is suitable for treatment of various types of thallium-containing wastewater.

This application relates to the technical field of batteries and specifically proposes a battery module and a battery pack. The battery module includes a solid-state battery pack and a binding strap. The solid-state battery pack includes multiple solid-state batteries arranged side by side along a first direction. The binding strap surrounds the outside of the solid-state battery pack and exerts a binding force on the multiple solid-state batteries to bring them closer together. In this application, the binding strap provides external force to constrain the multiple solid-state batteries, making the electrode plates and solid electrolyte in the solid-state batteries tightly bonded, improving the active ion transport speed, and ensuring battery performance. Moreover, the binding force provided by the binding strap on the solid-state batteries can also prevent them from bulging, allowing the gas generated inside the solid-state batteries to be discharged from the exhaust valve in a timely manner. In addition, the binding strap is arranged around the solid-state battery pack to apply an inward force to the entire solid-state battery pack, resulting in a good binding effect, making the solid-state batteries uniformly stressed, and avoiding damage to the solid-state batteries due to uneven stress.

The utility model provides a bundling device for bundling wires, and belongs to the technical field of wire processing equipment. Comprising a support, a first short shaft fixed to the support, a second short shaft rotationally connected to the support, a crankshaft fixed to the inner end of the second short shaft and two symmetrically-arranged material wheels, one material wheel is fixedly connected with the first short shaft, the other material wheel is fixedly connected with the second short shaft, the crankshaft is rotationally connected with the first short shaft, and a long-strip-shaped material groove is formed in each material wheel. The bottoms of the material grooves are semicircular, and when the crankshaft is vertically downward, the bottoms of the two material grooves are overlapped; and an opening of the trough faces upwards. The wire binding device has the advantages of being good in wire binding effect and the like.

This invention discloses a biomimetic nanobamboo based on centrally rigid tandem assembly (CRSA) technology and its application in the isolation of circulating tumor cells (CTCs). This biomimetic nanobamboo uses rigid triangular structural units with a Y-shaped framework as lateral partitions, and is longitudinally tandemly linked by rolling circle amplification products (sRCAp), cross-linked with linker molecules to form a super-large, highly rigid nanobamboo structure. Surface modification with targeted aptamers acts as "branches," and biotin modification is used for magnetic separation. This invention achieves highly efficient assembly of the nanobamboo using CRSA technology, with an assembly efficiency of 90%. Its structural rigidity is 33 times higher than that of traditional DNA nanotubes, and its resistance to nuclease degradation is enhanced by 30 times. Utilizing the multivalent aptamer binding effect and magnetic separation technology, this biomimetic nanobamboo can efficiently separate rare CTCs from whole blood samples, achieving a separation efficiency of 68.2 times and a purity of 75.6%, while maintaining good activity of the separated CTCs. This invention provides a novel tool for the precise isolation of CTCs and has significant application prospects in tumor metastasis early warning and precision medicine.

The application discloses a microfluidic chip design method and device based on a viscoelastic fluid binding effect, and the method comprises the following steps: selecting a microfluidic channel capable of effectively utilizing viscoelastic fluid instability to bind droplets; designing the size of the selected microfluidic channel; configuring a displacement fluid according to the size of the known microfluidic channel; constructing a viscoelastic fluid dynamics model according to the known microfluidic channel; determining critical conditions of droplet oscillation binding based on the viscoelastic fluid dynamics model and experimental results; and establishing a microfluidic design criterion based on viscoelastic fluid instability to bind droplets according to the critical conditions of droplet oscillation binding. The application can precisely and controllably realize oscillation binding of droplets based on the instability characteristics and unique microfluidic channel design of the viscoelastic fluid, so that the microfluidic chip with the oscillation binding function has a wider application scenario.

The invention provides a display panel, a manufacturing method thereof and a display device. The display panel comprises a display area and a non-display area surrounding the display area, the non-display area comprises binding areas arranged at intervals, each binding area is used for being bound with one integrated circuit chip, the display panel further comprises heat blocking structures arranged between the adjacent binding areas, and each heat blocking structure comprises a heat blocking opening penetrating through the display panel. According to the display panel disclosed by the embodiment of the invention, the heat-resistant openings penetrating through the display panel are formed between the adjacent binding areas, so that heat is prevented from being diffused to the periphery by using the heat-resistant openings when a current integrated circuit chip is bound, the binding effect of a subsequent chip is prevented from being influenced, and the binding reliability is improved.

The invention discloses a probe system for detecting Ox-LDL and application of the probe system, and belongs to the technical field of Ox-LDL detection. The probe system for detecting the Ox-LDL comprises a targeting molecule and a marker, the targeting molecule is bound to a target site Ox-LDL through a specific binding effect; the marker comprises A-X-Y, and A is a substituted or unsubstituted tetrazine group; the X can be default; x can be a linker, and the linker comprises at least one of an amido bond type linker, an ether bond type linker, a thioether bond type linker and a PEG type linker; y comprises at least one of radionuclide and a fluorescent element. According to the probe system, targeting specificity and a signal amplification effect are combined, high-sensitivity and high-specificity in-vivo visualization of an important disease biomarker Ox-LDL is achieved, and the probe system has scientific research value and clinical transformation potential.