36 results about "Binding effect" patented technology

This utility model discloses a 3D-printed outdoor shoe, belonging to the field of shoe technology. The shoe includes an upper and a sole. The sole includes a midsole and an outsole. The upper is fixedly connected to the midsole, and the midsole is fixedly connected to the outsole on the opposite side of the upper. Several loops are provided on both sides of the upper, passing through the upper and fixedly connected to the midsole. Shoelaces are threaded through the loops, alternately passing through the loops on both sides. The two ends of the shoelaces emerge from the loops near the shoe opening. The shoelaces are equipped with fastening elements for tightening. This utility model shifts the main stress point of the shoelaces from the upper to the midsole. The combination of the loops and shoelaces creates a binding effect on the foot, thus fixing the foot inside the shoe. This method reduces deformation of the upper and the need for elasticity, allowing for better adaptation to the 3D-printed upper.

An antibody-conjugated liposome, particularly a nanoparticle. The surface of the nanoparticle contains antibodies. The number of the antibodies is 5-60, preferably 5-50, and more preferably 5-40. The nanoparticle, for example, a liposome, can more effectively exert a therapeutic effect on tumor and improve multidrug resistance of tumor, thereby overcoming the technical prejudice that it is commonly considered that the more antibodies on a surface of a liposome, the better the target cell binding effect, and laying a foundation for further clinical development.An antibody-conjugated liposome, particularly a nanoparticle, the surface of which contains antibodies, and the number of the antibodies is 5-60, preferably 5-50, and more preferably 5-40. The nanoparticle, such as a liposome, can more effectively exert a therapeutic effect on tumors and reduce the multidrug resistance of tumors. This overcomes the generally accepted technical bias that more antibodies on the surface of a liposome lead to better binding with target cells, thereby laying the foundation for further clinical development.

The utility model provides an abdominal organ debirth binding protection device. The abdominal organ debirth binding protection device comprises a bowl body, a fixing band and dressing. The bowl body comprises a first bowl cylinder, a second bowl cylinder and a bowl bottom cover, one end of the first bowl cylinder is a bowl opening, the bowl opening covers the dressing, the other end of the first bowl cylinder is connected with one end of the second bowl cylinder through a thread structure, and the bowl bottom cover is detachably installed at the other end of the second bowl cylinder; a storage space is formed between the bowl bottom cover and the dressing, and a wetting liquid bag used for storing wetting liquid is stored in the storage space. The fixing band comprises a first band body and a second band body, one end of the first band body is connected with one side of the end where the bowl opening of the first bowl barrel is located, and the other end of the first band body is detachably connected with the other side of the end where the bowl opening of the first bowl barrel is located or detachably connected with the other side of the end where the bowl opening of the first bowl barrel is located through the second band body. The protection device can well bind abdominal cavity organ debirth, the binding effect is good, the protection device is provided with wetting liquid, and the protection device is convenient to carry and use when people go out.

The zipper tape coiling machine comprises a machine cabinet, a feeding mechanism, a first tape binding mechanism, a discharging mechanism and a second tape binding mechanism, and a machine head mechanism comprises a rotating plate, a first driving part for driving the rotating plate to rotate, a plurality of tape coiling discs, a second driving part for driving the tape coiling discs to rotate, a limiting disc and a third driving part for driving the limiting disc to linearly move; the first binding mechanism is used for binding the single side of the zipper roll, and the unloading mechanism is used for pushing the zipper roll to the next station from the material plate; the whole zipper roll is bundled by the second bundling mechanism; according to the zipper taping machine, the functions of automatic tape winding and automatic tape tying can be achieved, and the production efficiency is high; and when the automatic binding function is achieved, single-side binding and whole-roll binding can be conducted on the zipper roll, the binding effect is good, and loosening is not prone to occurring.

The application discloses a micro-bubble generating method and device. The micro-bubble generating method and device utilize high-speed liquid jet impact on gas and the binding effect of a rotary body structure on bubbles, so that the bubbles are frequently sheared and broken by the liquid jet to generate a large amount of micro-bubbles. Meanwhile, the wall jet formed by the high-speed liquid jet impact on a flat plate promotes the uniform dispersion of the micro-bubbles. The micro-bubble generating method and device have the advantages of simple structure, good micro-bubble generating effect, large gas processing capacity, low energy consumption and good bubble dispersion and mixing effect.

The present invention relates to a polypeptide forming one part of a two-part linker wherein the polypeptide (protein) spontaneously forms an isopeptide bond with a peptide tag, i.e. The other part of the two-part linker. The invention also relates to a method for producing a polypeptide of the invention and to the use of said polypeptide. According to the present invention, the reaction rate of the Sdy-Catcher variant obtained through mutation is significantly improved compared to the reaction rate of Sdy-Tag, such that the ideal direction is provided for the searching of polypeptides with characteristics of high binding rate and good binding effect in the field.

The invention discloses a binding device and method for thickened archive documents, the binding device comprises an outer cylinder shell (2) used for supporting the inner side face of the thickened archive documents, a pressing seat (4) arranged in the outer cylinder shell (2), and an inner cylinder shell (5) arranged between the pressing seat (4) and the outer cylinder shell (2), one side face of the thickened archive documents is supported through the outer cylinder shell (2), and the inner cylinder shell (5) is arranged between the pressing seat (4) and the outer cylinder shell (2). By means of an inner barrel shell (5), the binding operation space of a penetrating needle and a binding line on the thickened archive document is set, the thickened archive document in the binding state is placed in an arc-shaped gap, and the binding efficiency is improved. The technical problem that due to the fact that a penetrating needle is used, the area of a clamping point of the thickened archive document is limited by a clamp, and the thickened archive document can be misplaced under the action of crossing acting force of the penetrating needle is solved, and therefore the binding effect of the thickened archive document is improved.

The application relates to the technical field of batteries, and discloses an electrode assembly and a manufacturing tool thereof. The electrode assembly comprises an electrode assembly body, and a binding belt is sleeved on the surface of the electrode assembly body. The width of the binding belt is smaller than the height of the electrode assembly body, and the binding belt is located between the two end surfaces of the electrode assembly body. Based on the above-mentioned electrode assembly, the binding belt has a binding effect on the electrode assembly body by being sleeved on the surface of the electrode assembly body, so that the electrode assembly can be prevented from being wrinkled due to the influence of tension, and the electrode assembly can also be prevented from being wrinkled due to deformation in the process of soaking, so that the quality of the electrode assembly is ensured. Meanwhile, since the width of the binding belt is smaller than the height of the electrode assembly body, and the binding belt is located between the two end surfaces of the electrode assembly body, the binding belt can be prevented from affecting lug welding and subsequent electrode assembly soaking, so that the binding belt does not affect the normal function of the electrode assembly.

The utility model discloses a book sewing machine binding positioning device which comprises a book sewing machine body and a binding plate, the binding plate is arranged on the inner side of the book sewing machine body, positioning plates are arranged on the left side and the right side of the top of the binding plate, and moving holes are formed in the tops of the positioning plates. Limiting columns used in cooperation with the positioning plate are arranged on the front side and the rear side of an inner cavity of the moving hole correspondingly, a control device is arranged at the bottom of the binding plate, and supporting blocks used in cooperation with the control device are arranged on the left side and the right side of the bottom of the binding plate correspondingly. Through the cooperative use of the positioning plate, the control device and the fixing device, the problems that when an existing book sewing machine is used, a machined object is mostly placed on a binding plate and is positioned through a check block on the left side of the binding plate, but the two sides of the machined object cannot be positioned according to the sizes of different machined objects, and the working efficiency is high are solved. Therefore, the problem that the paper binding effect is affected due to the fact that the processed objects are likely to move in the binding process is solved.

The invention relates to the technical field of biological detection, in particular to a plasma cfDNA extraction kit and an extraction method. According to the plasma cfDNA extraction kit, on one hand, the lysis solution can ensure sufficient lysis, on the other hand, the influence on subsequent binding and the like can be reduced, the binding solution can better bind cfDNA and ensure a good binding effect, and the washing solution adopts dynamic pH washing, so that salt ions, hydrophobic impurities, proteins and the like can be more thoroughly removed; and the extracted DNA has high purity and high cfDNA content.

The utility model discloses an automatic bookbinding machine, which belongs to the technical field of bookbinding, and comprises a bookbinding device, a positioning device and a clamping and pushing device, the positioning device used for positioning a product before bookbinding and the clamping and pushing device used for pushing the product into a bookbinding station are arranged on the bookbinding device; the clamping and pushing device comprises a pushing assembly used for pushing the products, a follow-up clamping assembly used for limiting and clamping the products and an adjusting assembly assisting in adjusting the follow-up clamping assembly, the pushing assembly and the adjusting assembly are installed on the binding device, and the follow-up clamping assembly is connected with the pushing assembly and the adjusting assembly. By means of the mode, by arranging the positioning device, products are aligned in all directions during binding, the binding effect is good, by arranging the pushing assembly and the follow-up clamping assembly, the products can be clamped and fixed while being pushed to the binding station, and the situation that the binding effect is poor due to displacement in the pushing process is avoided.

The invention discloses a rapid hemostasis bandaging device for emergency treatment wounds, relates to the technical field of hemostasis bandaging instruments, and provides the following scheme that the rapid hemostasis bandaging device comprises a first-aid backpack, the front side of the first-aid backpack is connected with a bandaging disinfection mechanism, and the bottom surface of the bandaging disinfection mechanism is fixedly connected with a bandaging forceps mechanism. According to the scheme, the binding forceps mechanism and the binding and disinfecting mechanism are cooperatively matched, flexible opening and closing and stable fixing of the semi-annular grooves are achieved through hinging of forceps handles and the design of the torsional spring, and limb placement and operation are facilitated. The arrangement of the electromagnet is ingenious, the semi-annular strips are tightly connected when the semi-annular grooves are closed, the stability of the device in the binding process is ensured, and the binding effect is improved. The servo motor drives the semi-ring-shaped strip to do circular motion and is matched with the hemostatic bandage which is adhered to the limb in advance, so that the wound can be quickly and uniformly bound, and the time is saved. Atomizing nozzles are distributed in an annular array mode, wounds can be completely covered, and disinfectant is effectively sprayed for disinfection.

The invention relates to the technical field of biology, in particular to application of multi-ligand glycan-4 to regulation and control of intercellular function of macrophages and renal fibrosis. According to the application, the inhibitor for inhibiting the binding effect of the binding areas between the multi-ligand glycan-4 and the phagocytosis and cell movement protein 1 is used for preparing the accelerant for promoting the interburial function of the macrophages. The application is based on earlier-stage research finds that the platelet reaction protein 1 is combined with a multi-ligand glycan-4 receptor on the surface of macrophages, meanwhile, the platelet reaction protein 1 can promote combination between the multi-ligand glycan-4 and phagocytosis and cell movement protein 1, and the interburial function of the macrophages is inhibited. And an animal model of knocking down the multi-ligand glycan-4 can delay the progress of renal fibrosis. Therefore, the multi-ligand glycan-4 can regulate and control the cellular burial function of the macrophages and delay the process of renal fibrosis at the same time, and the blank that the cellular burial function of the targeted macrophages is applied to renal fibrosis treatment in the prior art is filled.

The invention discloses a buckle-free hairy crab binding machine, and relates to the technical field of binding machines. Comprising a machine body, an arc-shaped cover is fixedly installed on the machine body, a containing block is arranged in the arc-shaped cover, and a rope winding groove is formed in the containing block; an L-shaped frame plate is fixedly installed on the arc-shaped cover, an adjusting assembly is arranged on the L-shaped frame plate, a connecting transverse rod is arranged on the adjusting assembly, and a U-shaped frame plate is fixedly installed at the end of the connecting transverse rod. According to the crab binding machine, through effective cooperation of the adjusting assembly and the overturning assembly, it is ensured that crabs can be stably fixed in the containing block, potential safety hazards caused by manual pressing of workers are avoided, meanwhile, the crabs are prevented from being injured, the crabs can be automatically taken out of the containing block through the design of the lifting assembly, taking and placing work of operators is greatly facilitated, and the working efficiency is improved. And meanwhile, the position-adjustable wire feeding pipe is utilized to ensure that the tightness of the binding rope is moderate, so that the binding effect is improved, and the use effect of the binding machine is effectively improved.

This application discloses an immunoassay kit, its preparation method, and its application. The immunoassay kit includes a small peptide-coated solid-phase carrier, a bispecific antibody, and a labeled detection antibody. The bispecific antibody includes an anti-small peptide antibody and a linked capture antibody. The anti-small peptide antibody specifically binds to the small peptide, and both the capture antibody and the labeled detection antibody specifically bind to the target analyte and have different antigen recognition epitopes. The highly specific binding of the small peptide to the anti-small peptide antibody achieves efficient immobilization of the bispecific antibody, significantly improving antibody immobilization density and activity retention compared to traditional detection methods. The targeted binding effect of the bispecific antibody amplifies the detection signal while avoiding competitive interference from endogenous biotin, achieving highly sensitive and interference-resistant immunoassay.

The application discloses a well site pipe cable binding device and a binding control method. It relates to the technical field of in-situ leaching uranium well site cable and pipe material binding technology, and comprises a pipe cable embracing mechanism and a binding piece conveying mechanism connected with the end of the pipe cable embracing mechanism. The pipe cable is arranged in the pipe cable embracing mechanism. A driving mechanism is arranged on the pipe cable embracing mechanism. The binding piece conveying mechanism is used for driving the binding piece to move around the pipe cable in the circumferential direction under the driving of the driving mechanism, so that the pipe cable is fixed and bound. The application can improve the pipe cable binding efficiency and ensure the pipe cable binding effect.

The application provides a display panel, a preparation method of the display panel and a display device. The display panel is used for binding connection with a driving chip. The display panel comprises a binding area. The display panel comprises a substrate, an organic layer and a plurality of conductive parts which are stacked on the substrate in the binding area. The plurality of conductive parts are arranged at a side of the organic layer away from the substrate. The organic layer has a avoiding opening. The orthographic projection of the conductive part on the organic layer coincides with at least part of the avoiding opening. The organic layer in the avoiding opening is removed, so that the organic layer under the conductive part is reduced, thereby reducing the deformation degree of the organic layer in the binding process. Therefore, the display panel, the preparation method of the display panel and the display device provided by the application can improve the binding effect of the display panel and the driving chip, thereby ensuring the display effect of the display panel and the display device.

This utility model discloses a feeder for a perfect binding machine. It relates to the field of perfect binding machine technology and includes a fixed assembly. The fixed assembly contains a moving assembly, which includes a moving base. The moving base has a fixed groove. Moving side plate assemblies and fixed side plate assemblies are respectively located on both sides of the fixed groove. The fixed side plate assembly includes a fixed clamping plate and a second telescopic rod. The fixed clamping plate is fixedly connected to one side of the fixed groove. A second limiting groove is provided on one side of the fixed clamping plate. A second lifting bar is slidably connected inside the second limiting groove. A second guide plate is fixedly installed on the top of the second lifting bar. A lifting block is fixedly installed at the output end of the second telescopic rod. This utility model allows for adjustment of the height of the moving side plate assembly and the fixed side plate assembly, enabling the device to clamp and fix pages of different widths, improving the perfect binding effect and possessing high practical value.

The application discloses a DNA nano antisense drug targeting microRNA, a preparation method and application thereof. The DNA nano antisense drug comprises a DNA nanostructure as a carrier, antisense peptide nucleic acid and selected aptamer, the DNA nanostructure wraps the antisense peptide nucleic acid, and exposes the selected aptamer, the antisense peptide nucleic acid is connected to the 3' end of a staple chain constituting the DNA nanostructure, and the selected aptamer is modified to the 5' end extended from another staple chain constituting the DNA nanostructure, and the antisense peptide nucleic acid can specifically recognize target microRNA in tumor cells. The DNA nano antisense drug has the advantages of simple preparation process, low price and harmless metabolic products, has strong specific binding effect on target microRNA and can promote cell apoptosis, and has great application value in the field of anticancer drug preparation.

The utility model relates to a handcart for battery transportation, include: support, at least one mounting piece and bandage, be provided with support piece on the support, and mounting piece is slidably arranged on the support piece, in use, the bandage is installed between the mounting plate and the mounting ring, and the mounting plate and the mounting ring can cooperate with each other to limit the position of the bandage, after placing the goods needing transportation on the support piece, according to the type and the size of the goods, the position of the mounting plate is slid, the position of the bandage can be adjusted flexibly, and then the bandage can be pulled to tighten the goods. Through the above setting, the position of the binding can be flexibly selected to realize the best binding effect, and then the stability during transportation is improved.

This invention belongs to the field of microbial fertilizer and bioengineering technology, and discloses a modified graphene-immobilized functional strain and its applications. It includes optimizing the selection and preparation of the culture medium, strain activation and modified graphene immobilization, and identification of the binding effect. This invention achieves dual cost reduction, is suitable for industrial production, synergistically improves immobilization efficiency and strain stability, dually enhances strain activity and metabolic function, is environmentally friendly, and expands application scenarios.

The invention relates to the technical field of medical equipment, in particular to an intelligent binding device for a dysphoria child patient in the department of pediatrics, which comprises a placement frame, and a first equipment shell and a second equipment shell are respectively arranged on two sides of the placement frame; a first chest and abdomen binding belt and a second chest and abdomen binding belt are arranged on the first equipment shell and the second equipment shell correspondingly, binding range adjusting assemblies are arranged on the first equipment shell and the second equipment shell correspondingly, an air bag adjusting assembly is arranged on the inner side of the first chest and abdomen binding belt, and a tension collecting assembly is arranged on the second chest and abdomen binding belt; according to the device, dysphoria tension data of a child patient is collected in real time, self-adaptive adjustment of binding tightness is achieved based on the tension data, meanwhile, the two chest and abdomen binding belts are adopted to be interwoven, the binding pressure of the child patient is dispersed through an annular wrapping type structure, and the binding effect of the child patient is improved. The defect that an existing restraining device is difficult to adapt to dysphoria fluctuation of a child patient is overcome.

The invention relates to the field of steel strands, in particular to an automatic steel strand bundling manipulator. A steel strand automatic bundling mechanical arm comprises a mechanical clamp, a material pushing system is installed on the mechanical clamp, and the mechanical clamp is provided with a plurality of clamping blocks; the storage system is mounted on the mechanical clamp; and the bundling system is installed on the mechanical clamp, and the bundling system is located below the material storage system. Manual work is replaced by the device to achieve automatic bundling, meanwhile, the number of rotation turns of a second horizontal gear and the descending distance of a hydraulic lifter are controlled to enable the bundling torsion strength of each time to be basically consistent, the bundling compactness is guaranteed, and meanwhile the situation that steel strands are damaged due to too tight bundling or U-shaped bundling wires are broken in the subsequent transportation process due to deformation and strain is avoided; therefore, the bundling effect and the subsequent bundling stability are ensured.

Provided herein are reversibly activatable polypeptides comprising a dual-binding detection domain that facilitates reversible, cue-dependent activation and inactivation of an effector domain, such as IL-2 or IL-15. The dual-binding detection domain can be capable of binding the effector domain and an inducing moiety (such as LAG-3), but configured to only bind either the effector domain or the inducing moiety at one time, facilitating reversible activation and inactivation of the effector domain. This reversible, competitive binding can provide effector activity (for example, IL-2 or IL-15 receptor signaling) that is dependent on or is enhanced by the presence of the inducing moiety. Accordingly, reversibly activatable polypeptides disclosed herein can exhibit reduced background effector activity in the absence of or at a low concentration of inducing moiety, for example, lower IL-2 receptor signaling in the absence of LAG-3, reducing systemic IL-2 signaling and toxicity, while providing therapeutic benefits of targeted IL-2 signaling in the presence of LAG-3.

The invention discloses a display panel and a display device, which are characterized in that a block-up part is arranged in a binding area of a driving chip, and the block-up part can compensate the segment difference of different positions of a binding bonding pad; for example, the thickness of the display panel corresponding to the overlapping area of the binding bonding pad and the fan-out line is the same as the thickness of the display panel corresponding to the non-overlapping area of the binding bonding pad and the fan-out line, so that the height of each position of the binding bonding pad has no segment difference; and all positions of the binding pad are uniformly stressed, so that the binding effect is improved, and the product yield of the display panel is improved.

The invention relates to a composite material for adsorbing heavy metal thallium and a preparation method thereof, which are applied to the technical field of environmental functional materials. The composite material comprises a porous carrier, an organic ligand which is grafted on the porous carrier and has a specific binding effect on Tl < + >, and loaded metal sulfide nanoparticles. The preparation method is characterized in that the surface of the carrier is modified with a bifunctional coupling agent, a first functional group of the coupling agent is covalently bonded with an organic ligand, and a second functional group of the coupling agent is an active group capable of being coordinated with metal ions; the metal sulfide nanoparticles are generated in situ under the guidance of coordination of active groups. The preparation method comprises the steps of carrier coupling, capture unit grafting, metal ion coordination and enrichment, sulfur source introduction, selective in-situ vulcanization and the like. According to the method, high-selectivity adsorption and deep in-situ mineralization solidification of trace thallium ions in water are achieved, the synergistic effect is remarkable, secondary pollution can be effectively eradicated, the condition is mild, and the method is suitable for treatment of various types of thallium-containing wastewater.

This application relates to the technical field of batteries and specifically proposes a battery module and a battery pack. The battery module includes a solid-state battery pack and a binding strap. The solid-state battery pack includes multiple solid-state batteries arranged side by side along a first direction. The binding strap surrounds the outside of the solid-state battery pack and exerts a binding force on the multiple solid-state batteries to bring them closer together. In this application, the binding strap provides external force to constrain the multiple solid-state batteries, making the electrode plates and solid electrolyte in the solid-state batteries tightly bonded, improving the active ion transport speed, and ensuring battery performance. Moreover, the binding force provided by the binding strap on the solid-state batteries can also prevent them from bulging, allowing the gas generated inside the solid-state batteries to be discharged from the exhaust valve in a timely manner. In addition, the binding strap is arranged around the solid-state battery pack to apply an inward force to the entire solid-state battery pack, resulting in a good binding effect, making the solid-state batteries uniformly stressed, and avoiding damage to the solid-state batteries due to uneven stress.

The utility model discloses an FPC structure convenient for detection after binding of multiple ICs, comprising an FPC body, the FPC body is provided with two binding areas, the two binding areas are respectively provided with a first binding end and a second binding end, and the FPC body is bound and connected with TFT glass through the first binding end and the second binding end. According to the FPC structure convenient for detection after binding of multiple ICs provided by the utility model, the first binding end and the second binding end can be connected and conducted through the first conduction structure, and the first driving IC end and the second driving IC end can be connected and conducted through the second conduction structure, so that after the FPC body and TFT glass are bound, the FPC body and the TFT glass can be connected and conducted through the first conduction structure and the second conduction structure. The first binding end, the first driving IC end, the second binding end and the second driving IC end can be conducted in sequence, then a universal meter is connected to golden fingers on the outermost sides of the first binding end and the second binding end for testing, if the universal meter displays a short circuit, it is indicated that the binding effect is good, and if the universal meter displays a short circuit, rebinding is needed.

The utility model provides a bundling device for bundling wires, and belongs to the technical field of wire processing equipment. Comprising a support, a first short shaft fixed to the support, a second short shaft rotationally connected to the support, a crankshaft fixed to the inner end of the second short shaft and two symmetrically-arranged material wheels, one material wheel is fixedly connected with the first short shaft, the other material wheel is fixedly connected with the second short shaft, the crankshaft is rotationally connected with the first short shaft, and a long-strip-shaped material groove is formed in each material wheel. The bottoms of the material grooves are semicircular, and when the crankshaft is vertically downward, the bottoms of the two material grooves are overlapped; and an opening of the trough faces upwards. The wire binding device has the advantages of being good in wire binding effect and the like.

This invention discloses a biomimetic nanobamboo based on centrally rigid tandem assembly (CRSA) technology and its application in the isolation of circulating tumor cells (CTCs). This biomimetic nanobamboo uses rigid triangular structural units with a Y-shaped framework as lateral partitions, and is longitudinally tandemly linked by rolling circle amplification products (sRCAp), cross-linked with linker molecules to form a super-large, highly rigid nanobamboo structure. Surface modification with targeted aptamers acts as "branches," and biotin modification is used for magnetic separation. This invention achieves highly efficient assembly of the nanobamboo using CRSA technology, with an assembly efficiency of 90%. Its structural rigidity is 33 times higher than that of traditional DNA nanotubes, and its resistance to nuclease degradation is enhanced by 30 times. Utilizing the multivalent aptamer binding effect and magnetic separation technology, this biomimetic nanobamboo can efficiently separate rare CTCs from whole blood samples, achieving a separation efficiency of 68.2 times and a purity of 75.6%, while maintaining good activity of the separated CTCs. This invention provides a novel tool for the precise isolation of CTCs and has significant application prospects in tumor metastasis early warning and precision medicine.