82 results about "Binding effect" patented technology

The invention provides a binder, a negative pole piece and a battery, the binder comprises a polyimide binding material, the polyimide binding material comprises a first structural unit from an amino sulfonic acid monomer, a second structural unit from an amino monomer, and a third structural unit from an anhydride monomer; the mass percentage content of sulfonate radicals in the polyimide binding material is 15-35 wt%. The binder provided by the invention has a good binding effect, and is beneficial to improving the stability of the battery.

The utility model relates to a binding structure, a battery monomer, a battery and an electric device. The binding structure is arranged in the battery monomer, so that the binding structure is used as a part of the internal structure of the battery monomer, and therefore, during formation exhaust, the binding structure extrudes the surface of the electrode assembly under the binding of the inner wall of the shell, the internal pressure of the electrode assembly is increased, and gas generated in the electrode assembly can be discharged. By means of the design, no external clamp or other equipment is needed, and the formation exhaust cost is reduced. Meanwhile, the binding structure applies pressure to the electrode assembly in the battery monomer, so that an internal self-pressurization exhaust mode is realized, the pressure applying and binding effects are better, the exhaust effect is better, and the film forming quality is favorably improved.

Provided in the present invention is a high-efficiency and low-toxicity DNA and RNA lipid delivery carrier. In order to enrich the types of nucleic acid drug delivery carriers, improve the in-vivo delivery and expression effects of the nucleic acid drug and reduce the toxicity and side effects, a new ionizable lipid compound having a special structure is provided in the present invention. The compound has a good binding effect with a negatively-charged nucleic acid, which effectively prevents the premature degradation of the nucleic acid by a nuclease in a cell and facilitates the passage of a liposome loaded with the nucleic acid through a cell membrane. Effective degradation and rapid removal can be achieved, the toxicity and side effects of the nucleic acid drug are reduced, and a nucleic acid drug delivery carrier truly having a high transfection efficiency, a high expression level and a low toxicity can be formed.

The utility model relates to the technical field of full-automatic bookbinding machines, in particular to a full-automatic bookbinding machine which comprises a bookbinding table, the inner wall of the bookbinding table is rotationally connected with two belt pulleys, a conveying belt is in transmission connection between the surfaces of the two belt pulleys, the two sides of the inner wall of the bookbinding table are fixedly connected with electric push rods, and the electric push rods are fixedly connected with the conveying belt. The telescopic end of one electric push rod is fixedly connected with a drill bit, and the telescopic end of the other electric push rod is fixedly connected with a hot riveting head. According to the device, a threaded rod, a supporting frame and a limiting wheel are used for achieving abutting limiting of printing paper, it is guaranteed that the printing paper does not deviate when the automatic binding machine binds the printing paper, then the binding effect on the printing paper is guaranteed, a baffle, a transparent plate and a first spring are used for achieving primary limiting of the printing paper, and the binding efficiency of the printing paper is improved. And the phenomenon that the conveying belt deviates in the printing paper conveying process is avoided.

The utility model provides a combined type automatic binding belt, which relates to the technical field of material packaging and comprises a binding belt, a magnetic suction head component is arranged on the binding belt, and a magnetic suction cover component is arranged on one side, close to the magnetic suction head component, of the binding belt. By means of the design of a spring pin installation base, a spring pin shaft and a spring pin spring in the magnetic attraction base, the binding belt can be automatically aligned and fixed in the use process, the operation convenience is improved, meanwhile, by means of the arrangement of a compression spring and a strong magnetic block on the supporting pad, it is ensured that the magnetic attraction force is strong enough, and the binding effect is good. According to the binding device, the metal cover can be firmly attracted to the metal cover, falling caused by vibration or external force is prevented, in addition, due to the design of the guide threaded bearing and the demagnetizing lifting pin on the metal cover, binding and unbinding operation is further facilitated, and therefore the technical problem of a safe and efficient binding mode is solved.

The present invention relates to a novel metal-organic framework (MOF) and a preparation method thereof, and specifically to a surface-modified novel metal-organic framework which, compared to a metal-organic framework which has not been surface-modified, has an increased specific surface area and a large pore diameter. In addition, the surface-modified metal-organic framework prepared by the preparation method for a novel metal-organic framework according to the present invention has an excellent binding effect with nucleic acids, and thus can be used as a carrier for nucleic acids.

This utility model discloses a 3D-printed outdoor shoe, belonging to the field of shoe technology. The shoe includes an upper and a sole. The sole includes a midsole and an outsole. The upper is fixedly connected to the midsole, and the midsole is fixedly connected to the outsole on the opposite side of the upper. Several loops are provided on both sides of the upper, passing through the upper and fixedly connected to the midsole. Shoelaces are threaded through the loops, alternately passing through the loops on both sides. The two ends of the shoelaces emerge from the loops near the shoe opening. The shoelaces are equipped with fastening elements for tightening. This utility model shifts the main stress point of the shoelaces from the upper to the midsole. The combination of the loops and shoelaces creates a binding effect on the foot, thus fixing the foot inside the shoe. This method reduces deformation of the upper and the need for elasticity, allowing for better adaptation to the 3D-printed upper.

An antibody-conjugated liposome, particularly a nanoparticle. The surface of the nanoparticle contains antibodies. The number of the antibodies is 5-60, preferably 5-50, and more preferably 5-40. The nanoparticle, for example, a liposome, can more effectively exert a therapeutic effect on tumor and improve multidrug resistance of tumor, thereby overcoming the technical prejudice that it is commonly considered that the more antibodies on a surface of a liposome, the better the target cell binding effect, and laying a foundation for further clinical development.An antibody-conjugated liposome, particularly a nanoparticle, the surface of which contains antibodies, and the number of the antibodies is 5-60, preferably 5-50, and more preferably 5-40. The nanoparticle, such as a liposome, can more effectively exert a therapeutic effect on tumors and reduce the multidrug resistance of tumors. This overcomes the generally accepted technical bias that more antibodies on the surface of a liposome lead to better binding with target cells, thereby laying the foundation for further clinical development.

The utility model provides an abdominal organ debirth binding protection device. The abdominal organ debirth binding protection device comprises a bowl body, a fixing band and dressing. The bowl body comprises a first bowl cylinder, a second bowl cylinder and a bowl bottom cover, one end of the first bowl cylinder is a bowl opening, the bowl opening covers the dressing, the other end of the first bowl cylinder is connected with one end of the second bowl cylinder through a thread structure, and the bowl bottom cover is detachably installed at the other end of the second bowl cylinder; a storage space is formed between the bowl bottom cover and the dressing, and a wetting liquid bag used for storing wetting liquid is stored in the storage space. The fixing band comprises a first band body and a second band body, one end of the first band body is connected with one side of the end where the bowl opening of the first bowl barrel is located, and the other end of the first band body is detachably connected with the other side of the end where the bowl opening of the first bowl barrel is located or detachably connected with the other side of the end where the bowl opening of the first bowl barrel is located through the second band body. The protection device can well bind abdominal cavity organ debirth, the binding effect is good, the protection device is provided with wetting liquid, and the protection device is convenient to carry and use when people go out.

The zipper tape coiling machine comprises a machine cabinet, a feeding mechanism, a first tape binding mechanism, a discharging mechanism and a second tape binding mechanism, and a machine head mechanism comprises a rotating plate, a first driving part for driving the rotating plate to rotate, a plurality of tape coiling discs, a second driving part for driving the tape coiling discs to rotate, a limiting disc and a third driving part for driving the limiting disc to linearly move; the first binding mechanism is used for binding the single side of the zipper roll, and the unloading mechanism is used for pushing the zipper roll to the next station from the material plate; the whole zipper roll is bundled by the second bundling mechanism; according to the zipper taping machine, the functions of automatic tape winding and automatic tape tying can be achieved, and the production efficiency is high; and when the automatic binding function is achieved, single-side binding and whole-roll binding can be conducted on the zipper roll, the binding effect is good, and loosening is not prone to occurring.

The application discloses a micro-bubble generating method and device. The micro-bubble generating method and device utilize high-speed liquid jet impact on gas and the binding effect of a rotary body structure on bubbles, so that the bubbles are frequently sheared and broken by the liquid jet to generate a large amount of micro-bubbles. Meanwhile, the wall jet formed by the high-speed liquid jet impact on a flat plate promotes the uniform dispersion of the micro-bubbles. The micro-bubble generating method and device have the advantages of simple structure, good micro-bubble generating effect, large gas processing capacity, low energy consumption and good bubble dispersion and mixing effect.

The present invention relates to a polypeptide forming one part of a two-part linker wherein the polypeptide (protein) spontaneously forms an isopeptide bond with a peptide tag, i.e. The other part of the two-part linker. The invention also relates to a method for producing a polypeptide of the invention and to the use of said polypeptide. According to the present invention, the reaction rate of the Sdy-Catcher variant obtained through mutation is significantly improved compared to the reaction rate of Sdy-Tag, such that the ideal direction is provided for the searching of polypeptides with characteristics of high binding rate and good binding effect in the field.

The invention discloses a binding device and method for thickened archive documents, the binding device comprises an outer cylinder shell (2) used for supporting the inner side face of the thickened archive documents, a pressing seat (4) arranged in the outer cylinder shell (2), and an inner cylinder shell (5) arranged between the pressing seat (4) and the outer cylinder shell (2), one side face of the thickened archive documents is supported through the outer cylinder shell (2), and the inner cylinder shell (5) is arranged between the pressing seat (4) and the outer cylinder shell (2). By means of an inner barrel shell (5), the binding operation space of a penetrating needle and a binding line on the thickened archive document is set, the thickened archive document in the binding state is placed in an arc-shaped gap, and the binding efficiency is improved. The technical problem that due to the fact that a penetrating needle is used, the area of a clamping point of the thickened archive document is limited by a clamp, and the thickened archive document can be misplaced under the action of crossing acting force of the penetrating needle is solved, and therefore the binding effect of the thickened archive document is improved.

The invention provides a spiro compound which is shown in a formula I and has a binding effect with E3 ligase protein CRBN, and application of the spiro compound in preparation of a medicine for treating cell abnormal proliferation diseases. # imgabs0 #

The application relates to the technical field of batteries, and discloses an electrode assembly and a manufacturing tool thereof. The electrode assembly comprises an electrode assembly body, and a binding belt is sleeved on the surface of the electrode assembly body. The width of the binding belt is smaller than the height of the electrode assembly body, and the binding belt is located between the two end surfaces of the electrode assembly body. Based on the above-mentioned electrode assembly, the binding belt has a binding effect on the electrode assembly body by being sleeved on the surface of the electrode assembly body, so that the electrode assembly can be prevented from being wrinkled due to the influence of tension, and the electrode assembly can also be prevented from being wrinkled due to deformation in the process of soaking, so that the quality of the electrode assembly is ensured. Meanwhile, since the width of the binding belt is smaller than the height of the electrode assembly body, and the binding belt is located between the two end surfaces of the electrode assembly body, the binding belt can be prevented from affecting lug welding and subsequent electrode assembly soaking, so that the binding belt does not affect the normal function of the electrode assembly.

The utility model discloses a book sewing machine binding positioning device which comprises a book sewing machine body and a binding plate, the binding plate is arranged on the inner side of the book sewing machine body, positioning plates are arranged on the left side and the right side of the top of the binding plate, and moving holes are formed in the tops of the positioning plates. Limiting columns used in cooperation with the positioning plate are arranged on the front side and the rear side of an inner cavity of the moving hole correspondingly, a control device is arranged at the bottom of the binding plate, and supporting blocks used in cooperation with the control device are arranged on the left side and the right side of the bottom of the binding plate correspondingly. Through the cooperative use of the positioning plate, the control device and the fixing device, the problems that when an existing book sewing machine is used, a machined object is mostly placed on a binding plate and is positioned through a check block on the left side of the binding plate, but the two sides of the machined object cannot be positioned according to the sizes of different machined objects, and the working efficiency is high are solved. Therefore, the problem that the paper binding effect is affected due to the fact that the processed objects are likely to move in the binding process is solved.

The present invention relates to the field of cosmetics, and in particular to a supramolecular eutectic gel that efficiently targets MC1R, and its preparation and application. The supramolecular eutectic gel that efficiently targets MC1R according to the present invention comprises the following components in parts by weight: 1-5 parts of glabridin, 1-6.5 parts of glycyrrhetinic acid, 3-23 parts of C3-C4 alcohol, and 0.001-0.1 parts of a targeting active substance. The present invention compounds glabridin and glycyrrhetinic acid, with glycyrrhetinic acid serving as a hydrogen bond acceptor and glabridin serving as a hydrogen bond donor. In a small amount of C3-C4 alcohol, supramolecular eutectics can be formed through π-π stacking and hydrogen bonding, thereby improving the stability and skin permeability of glabridin. The targeting active substance has a significant binding effect with MC1R, achieving the effect of synergistically promoting efficient whitening. The present invention combines supramolecular eutectic and nanoliposome technology to obtain whitening liposomes, which have excellent whitening efficacy, clear targets, efficient penetration, high utilization rate, and are easy to mass produce.

The invention relates to the technical field of biological detection, in particular to a plasma cfDNA extraction kit and an extraction method. According to the plasma cfDNA extraction kit, on one hand, the lysis solution can ensure sufficient lysis, on the other hand, the influence on subsequent binding and the like can be reduced, the binding solution can better bind cfDNA and ensure a good binding effect, and the washing solution adopts dynamic pH washing, so that salt ions, hydrophobic impurities, proteins and the like can be more thoroughly removed; and the extracted DNA has high purity and high cfDNA content.

The utility model relates to the technical field of electronic wire harnesses, in particular to an electronic wire harness with a self-binding property, and compared with the prior art, the electronic wire harness with the self-binding property effectively solves the problems that a wire body is protected and isolated through a fixing assembly by placing a wire into a combined groove, and the wire body is not easy to store due to too many wire harnesses of a product. The problems that wires are fixed through fixing blocks, combined grooves and fixing assemblies are used for storing and classifying the wires and protecting the interior of the wire body are solved, and the problem that when an existing electronic wire harness is used, due to the fact that the wire harness has a multi-wire structural form, the wire harness is convenient to store or classify, and the wire harness is not convenient to store or classify is effectively solved. The problems that in an existing wire harness, too many wires are bound together through a binding belt, the internal structure of the wire harness is affected after long-time binding, a binding assembly is oxidized, and the binding effect is affected are solved, and therefore the service life of the wires is prolonged.

The invention relates to a conductive reinforced flame-retardant PBT (Polybutylene Terephthalate) material. The conductive reinforced flame-retardant PBT material is prepared from the following components in parts by mass: 50 to 70 parts of PBT resin, 15 to 30 parts of modified compatilizer, 10 to 20 parts of halogen-free flame retardant and 0.1 to 2 parts of additive, wherein the modified compatilizer is a ternary random copolymer obtained by melting PE (Polyethylene), glycidyl methacrylate and carbon nanotube grafted acrylate at high temperature. The modified compatilizer is compounded with the PBT resin, the flame retardant and other components, the compatibilization effect is good, the combination effect among multiple components is improved, the mechanical property of the composite material is guaranteed, meanwhile, the product is endowed with better conductivity and flame retardance, and the defects existing in existing products are overcome.

The invention discloses a binding method and system for a distribution network wire and an insulator. The binding connection position between the distribution network wire and the insulator is defined based on a binding space; binding of the distribution network wire and the insulator is triggered based on the response of the binding connection position, and intelligent management and control of the binding space and the binding connection position are achieved. Defining a binding type according to the model of the distribution network wire, the model of the insulator and a preset binding force, wherein the binding type is matched with the binding track; after binding of the distribution network wire and the insulator is completed, a working scene of the distribution network wire and the insulator is defined according to the multiple environmental parameters, detection time is defined according to the influence parameters corresponding to the working scene and the binding coefficient of the binding type, and the distribution network wire and the insulator are bound again based on the detection time. The overall consideration of first binding of the distribution network wire and the insulator and secondary binding of the distribution network wire and the insulator is compatible, and the binding effect of the distribution network wire and the insulator is improved.

The utility model relates to the technical field of packaging bags, in particular to a packaging bag with an opening binding function, which comprises a packaging bag main body, an elastic band opening and an opening binding rope, the elastic band opening is arranged above the packaging bag main body, the opening binding rope penetrates through the inside of the elastic band opening, and the elastic band opening is tightened through the opening binding rope. A control rope is fixed to the right end of the opening binding rope, the opening binding rope is controlled through the control rope, an auxiliary block is arranged on the outer side of the control rope, the auxiliary block is arranged on the outer side of the elastic band opening, and a winding shaft is arranged in the auxiliary block. According to the packaging bag with the opening binding function, the opening binding rope can be tensioned through the control rope to tighten the opening of the elastic band, the opening binding effect is achieved, the redundant control rope after opening binding can be collected in the auxiliary block, the rope body is prevented from being scattered and wound, and the risk that the rope body is hung and makes contact with an external object is also reduced.

Disclosed are pyridine derivatives and their application in medicine. The pyridine derivatives have good binding effect with LANCL2 protein and have significant medicinal effects on ulcerative colitis.

The utility model discloses an automatic bookbinding machine, which belongs to the technical field of bookbinding, and comprises a bookbinding device, a positioning device and a clamping and pushing device, the positioning device used for positioning a product before bookbinding and the clamping and pushing device used for pushing the product into a bookbinding station are arranged on the bookbinding device; the clamping and pushing device comprises a pushing assembly used for pushing the products, a follow-up clamping assembly used for limiting and clamping the products and an adjusting assembly assisting in adjusting the follow-up clamping assembly, the pushing assembly and the adjusting assembly are installed on the binding device, and the follow-up clamping assembly is connected with the pushing assembly and the adjusting assembly. By means of the mode, by arranging the positioning device, products are aligned in all directions during binding, the binding effect is good, by arranging the pushing assembly and the follow-up clamping assembly, the products can be clamped and fixed while being pushed to the binding station, and the situation that the binding effect is poor due to displacement in the pushing process is avoided.

A preparation method of an extracellular vesicle drug delivery system belongs to the field of extracellular vesicles, and comprises the following steps: firstly, representing extracellular vesicles through a transmission electron microscope and a dynamic light scattering method, constructing a multi-dimensional feature matrix and calculating a stability coefficient; mixing the screened qualified vesicles with polyethylene glycol, and regulating and controlling the mixing process by adopting an online monitoring system; then adding chitosan and adjusting the pH value, and controlling process parameters through an intelligent automatic titration system; a targeting ligand is added for modification, and a high-throughput analysis system is adopted to evaluate the binding effect; after precise filtration sterilization and ultrafiltration centrifugal separation, a trehalose protective agent is added, finally, drying treatment is conducted through an intelligent freeze drying system, and a final product is obtained. The technical problem of unstable preparation quality caused by insufficient stability control in the preparation process of an extracellular vesicle drug delivery system in the prior art is solved.

The utility model relates to the technical field of binding shoes, in particular to a binding shoe with an anti-falling structure, which comprises a shoe body, a binding rope is wound on the outer edge of the shoe body, a positioning frame is fixedly connected to the outer side of the binding rope, a rotating ring is rotatably connected to the inner wall of the positioning frame, and one end of an inserting rod is fixedly connected to the outer edge of the rotating ring. The sides, away from the positioning frames, of the binding ropes are inserted into the inner walls of the positioning frames, then the inserting rods are inserted into the inner walls of the inserting holes, the shoe bodies can be firmly located on the outer sides of the shanks of a user, the binding effect on the legs of the user is achieved, and falling is prevented; the problems that a dysphoria patient in the psychiatry department cannot control own behaviors due to fuzzy consciousness, the feet of the patient are greatly hurt due to the fact that the shoes fall off when intense reaction occurs, and safety is insufficient are solved, the inserting rods can be inserted into the inserting holes in different positions, the binding tightness is adjusted, and the comfort of a user is improved.

The present invention discloses a cable product binding device, including a wire binding mechanism, a wire sleeve fixing mechanism, a wire tightening mechanism, and a wire holding mechanism arranged on a fixed plate. The wire binding mechanism is arranged on the right side of the fixed plate and is used for rotating the wire binding. The wire sleeve fixing mechanism is arranged on the right side of the wire binding mechanism and is used for fixing the binding wire sleeve. The wire tightening mechanism and the wire holding mechanism are both arranged on the left side of the fixed plate. The wire holding mechanism is used for fixing the cable harness. The wire tightening mechanism is used for fixing the binding wire end and performing the wire tightening operation after the wire binding is completed. The present invention is applicable to the technical field of cable products. By arranging the wire binding mechanism, the wire sleeve fixing mechanism, the wire tightening mechanism, and the wire holding mechanism, the cable product harness can be quickly bound. During the binding process, it is ensured that each circle of wire is evenly stressed when wrapped around the cable harness, and the binding effect is good. At the same time, the possibility of worker injury is reduced, and the device is safe and efficient.

The utility model provides a bandaging auxiliary tool, belongs to the technical field of medical instruments, and aims to solve the problems that the workload of medical staff is increased, and the bandaging efficiency of legs of a patient is affected due to the fact that bandages are inconvenient to wind due to shielding of arc-shaped supports on the two sides. The angle control frame is arranged above the positioning support, and the front end of the angle control frame is hinged to the positioning support; the angle control mechanism is arranged between the positioning support and the angle control frame; the two annular supports are fixedly connected to the front side and the rear side of the top end face of the angle control frame correspondingly. The binding auxiliary mechanism is arranged on the front side of the rear-end annular bracket; by means of the device, the bandage can be automatically wound on the legs of the patient, the workload of medical staff is relieved, meanwhile, the tightness and uniformity of the bandage wound on the legs of the patient are improved when the patient is bound, and the binding efficiency and the binding effect on the patient are improved.

The utility model discloses a feeding tool for target material binding. The feeding tool comprises a tool body and a plurality of positioning pieces. A feeding hole is formed in the tool body in a penetrating mode, the tool body is used for being detachably connected to the target material cylinder, a feeding gap is formed between the inner wall of the feeding hole and the back pipe, and the feeding gap communicates with a gap between the target material cylinder and the back pipe; the multiple positioning pieces are connected to the tool body and distributed in the circumferential direction of the feeding hole at intervals, the position of each positioning piece can be adjusted in the radial direction of the feeding hole so as to pass through multiple positioning positions, the positioning positions of all the positioning pieces are in one-to-one correspondence in the circumferential direction of the feeding hole, and all the positioning pieces can abut against the outer side wall of the target material cylinder at the same time. Therefore, the feeding gaps formed between the inner wall of the feeding hole and the back pipe are evenly distributed, the situation of uneven distribution during brazing filler metal filling is avoided, the problem of poor binding such as eccentricity is further avoided, and the binding effect is improved. The utility model also discloses a binding device.