62 results about "Binding effect" patented technology

The utility model provides a combined type automatic binding belt, which relates to the technical field of material packaging and comprises a binding belt, a magnetic suction head component is arranged on the binding belt, and a magnetic suction cover component is arranged on one side, close to the magnetic suction head component, of the binding belt. By means of the design of a spring pin installation base, a spring pin shaft and a spring pin spring in the magnetic attraction base, the binding belt can be automatically aligned and fixed in the use process, the operation convenience is improved, meanwhile, by means of the arrangement of a compression spring and a strong magnetic block on the supporting pad, it is ensured that the magnetic attraction force is strong enough, and the binding effect is good. According to the binding device, the metal cover can be firmly attracted to the metal cover, falling caused by vibration or external force is prevented, in addition, due to the design of the guide threaded bearing and the demagnetizing lifting pin on the metal cover, binding and unbinding operation is further facilitated, and therefore the technical problem of a safe and efficient binding mode is solved.

The present invention relates to a novel metal-organic framework (MOF) and a preparation method thereof, and specifically to a surface-modified novel metal-organic framework which, compared to a metal-organic framework which has not been surface-modified, has an increased specific surface area and a large pore diameter. In addition, the surface-modified metal-organic framework prepared by the preparation method for a novel metal-organic framework according to the present invention has an excellent binding effect with nucleic acids, and thus can be used as a carrier for nucleic acids.

This utility model discloses a 3D-printed outdoor shoe, belonging to the field of shoe technology. The shoe includes an upper and a sole. The sole includes a midsole and an outsole. The upper is fixedly connected to the midsole, and the midsole is fixedly connected to the outsole on the opposite side of the upper. Several loops are provided on both sides of the upper, passing through the upper and fixedly connected to the midsole. Shoelaces are threaded through the loops, alternately passing through the loops on both sides. The two ends of the shoelaces emerge from the loops near the shoe opening. The shoelaces are equipped with fastening elements for tightening. This utility model shifts the main stress point of the shoelaces from the upper to the midsole. The combination of the loops and shoelaces creates a binding effect on the foot, thus fixing the foot inside the shoe. This method reduces deformation of the upper and the need for elasticity, allowing for better adaptation to the 3D-printed upper.

An antibody-conjugated liposome, particularly a nanoparticle. The surface of the nanoparticle contains antibodies. The number of the antibodies is 5-60, preferably 5-50, and more preferably 5-40. The nanoparticle, for example, a liposome, can more effectively exert a therapeutic effect on tumor and improve multidrug resistance of tumor, thereby overcoming the technical prejudice that it is commonly considered that the more antibodies on a surface of a liposome, the better the target cell binding effect, and laying a foundation for further clinical development.An antibody-conjugated liposome, particularly a nanoparticle, the surface of which contains antibodies, and the number of the antibodies is 5-60, preferably 5-50, and more preferably 5-40. The nanoparticle, such as a liposome, can more effectively exert a therapeutic effect on tumors and reduce the multidrug resistance of tumors. This overcomes the generally accepted technical bias that more antibodies on the surface of a liposome lead to better binding with target cells, thereby laying the foundation for further clinical development.

The utility model provides an abdominal organ debirth binding protection device. The abdominal organ debirth binding protection device comprises a bowl body, a fixing band and dressing. The bowl body comprises a first bowl cylinder, a second bowl cylinder and a bowl bottom cover, one end of the first bowl cylinder is a bowl opening, the bowl opening covers the dressing, the other end of the first bowl cylinder is connected with one end of the second bowl cylinder through a thread structure, and the bowl bottom cover is detachably installed at the other end of the second bowl cylinder; a storage space is formed between the bowl bottom cover and the dressing, and a wetting liquid bag used for storing wetting liquid is stored in the storage space. The fixing band comprises a first band body and a second band body, one end of the first band body is connected with one side of the end where the bowl opening of the first bowl barrel is located, and the other end of the first band body is detachably connected with the other side of the end where the bowl opening of the first bowl barrel is located or detachably connected with the other side of the end where the bowl opening of the first bowl barrel is located through the second band body. The protection device can well bind abdominal cavity organ debirth, the binding effect is good, the protection device is provided with wetting liquid, and the protection device is convenient to carry and use when people go out.

The zipper tape coiling machine comprises a machine cabinet, a feeding mechanism, a first tape binding mechanism, a discharging mechanism and a second tape binding mechanism, and a machine head mechanism comprises a rotating plate, a first driving part for driving the rotating plate to rotate, a plurality of tape coiling discs, a second driving part for driving the tape coiling discs to rotate, a limiting disc and a third driving part for driving the limiting disc to linearly move; the first binding mechanism is used for binding the single side of the zipper roll, and the unloading mechanism is used for pushing the zipper roll to the next station from the material plate; the whole zipper roll is bundled by the second bundling mechanism; according to the zipper taping machine, the functions of automatic tape winding and automatic tape tying can be achieved, and the production efficiency is high; and when the automatic binding function is achieved, single-side binding and whole-roll binding can be conducted on the zipper roll, the binding effect is good, and loosening is not prone to occurring.

The application discloses a micro-bubble generating method and device. The micro-bubble generating method and device utilize high-speed liquid jet impact on gas and the binding effect of a rotary body structure on bubbles, so that the bubbles are frequently sheared and broken by the liquid jet to generate a large amount of micro-bubbles. Meanwhile, the wall jet formed by the high-speed liquid jet impact on a flat plate promotes the uniform dispersion of the micro-bubbles. The micro-bubble generating method and device have the advantages of simple structure, good micro-bubble generating effect, large gas processing capacity, low energy consumption and good bubble dispersion and mixing effect.

The present invention relates to a polypeptide forming one part of a two-part linker wherein the polypeptide (protein) spontaneously forms an isopeptide bond with a peptide tag, i.e. The other part of the two-part linker. The invention also relates to a method for producing a polypeptide of the invention and to the use of said polypeptide. According to the present invention, the reaction rate of the Sdy-Catcher variant obtained through mutation is significantly improved compared to the reaction rate of Sdy-Tag, such that the ideal direction is provided for the searching of polypeptides with characteristics of high binding rate and good binding effect in the field.

The invention discloses a binding device and method for thickened archive documents, the binding device comprises an outer cylinder shell (2) used for supporting the inner side face of the thickened archive documents, a pressing seat (4) arranged in the outer cylinder shell (2), and an inner cylinder shell (5) arranged between the pressing seat (4) and the outer cylinder shell (2), one side face of the thickened archive documents is supported through the outer cylinder shell (2), and the inner cylinder shell (5) is arranged between the pressing seat (4) and the outer cylinder shell (2). By means of an inner barrel shell (5), the binding operation space of a penetrating needle and a binding line on the thickened archive document is set, the thickened archive document in the binding state is placed in an arc-shaped gap, and the binding efficiency is improved. The technical problem that due to the fact that a penetrating needle is used, the area of a clamping point of the thickened archive document is limited by a clamp, and the thickened archive document can be misplaced under the action of crossing acting force of the penetrating needle is solved, and therefore the binding effect of the thickened archive document is improved.

The invention provides a spiro compound which is shown in a formula I and has a binding effect with E3 ligase protein CRBN, and application of the spiro compound in preparation of a medicine for treating cell abnormal proliferation diseases. # imgabs0 #

The application relates to the technical field of batteries, and discloses an electrode assembly and a manufacturing tool thereof. The electrode assembly comprises an electrode assembly body, and a binding belt is sleeved on the surface of the electrode assembly body. The width of the binding belt is smaller than the height of the electrode assembly body, and the binding belt is located between the two end surfaces of the electrode assembly body. Based on the above-mentioned electrode assembly, the binding belt has a binding effect on the electrode assembly body by being sleeved on the surface of the electrode assembly body, so that the electrode assembly can be prevented from being wrinkled due to the influence of tension, and the electrode assembly can also be prevented from being wrinkled due to deformation in the process of soaking, so that the quality of the electrode assembly is ensured. Meanwhile, since the width of the binding belt is smaller than the height of the electrode assembly body, and the binding belt is located between the two end surfaces of the electrode assembly body, the binding belt can be prevented from affecting lug welding and subsequent electrode assembly soaking, so that the binding belt does not affect the normal function of the electrode assembly.

The utility model discloses a book sewing machine binding positioning device which comprises a book sewing machine body and a binding plate, the binding plate is arranged on the inner side of the book sewing machine body, positioning plates are arranged on the left side and the right side of the top of the binding plate, and moving holes are formed in the tops of the positioning plates. Limiting columns used in cooperation with the positioning plate are arranged on the front side and the rear side of an inner cavity of the moving hole correspondingly, a control device is arranged at the bottom of the binding plate, and supporting blocks used in cooperation with the control device are arranged on the left side and the right side of the bottom of the binding plate correspondingly. Through the cooperative use of the positioning plate, the control device and the fixing device, the problems that when an existing book sewing machine is used, a machined object is mostly placed on a binding plate and is positioned through a check block on the left side of the binding plate, but the two sides of the machined object cannot be positioned according to the sizes of different machined objects, and the working efficiency is high are solved. Therefore, the problem that the paper binding effect is affected due to the fact that the processed objects are likely to move in the binding process is solved.

The present invention relates to the field of cosmetics, and in particular to a supramolecular eutectic gel that efficiently targets MC1R, and its preparation and application. The supramolecular eutectic gel that efficiently targets MC1R according to the present invention comprises the following components in parts by weight: 1-5 parts of glabridin, 1-6.5 parts of glycyrrhetinic acid, 3-23 parts of C3-C4 alcohol, and 0.001-0.1 parts of a targeting active substance. The present invention compounds glabridin and glycyrrhetinic acid, with glycyrrhetinic acid serving as a hydrogen bond acceptor and glabridin serving as a hydrogen bond donor. In a small amount of C3-C4 alcohol, supramolecular eutectics can be formed through π-π stacking and hydrogen bonding, thereby improving the stability and skin permeability of glabridin. The targeting active substance has a significant binding effect with MC1R, achieving the effect of synergistically promoting efficient whitening. The present invention combines supramolecular eutectic and nanoliposome technology to obtain whitening liposomes, which have excellent whitening efficacy, clear targets, efficient penetration, high utilization rate, and are easy to mass produce.

The invention relates to the technical field of biological detection, in particular to a plasma cfDNA extraction kit and an extraction method. According to the plasma cfDNA extraction kit, on one hand, the lysis solution can ensure sufficient lysis, on the other hand, the influence on subsequent binding and the like can be reduced, the binding solution can better bind cfDNA and ensure a good binding effect, and the washing solution adopts dynamic pH washing, so that salt ions, hydrophobic impurities, proteins and the like can be more thoroughly removed; and the extracted DNA has high purity and high cfDNA content.

Disclosed are pyridine derivatives and their application in medicine. The pyridine derivatives have good binding effect with LANCL2 protein and have significant medicinal effects on ulcerative colitis.

The utility model discloses an automatic bookbinding machine, which belongs to the technical field of bookbinding, and comprises a bookbinding device, a positioning device and a clamping and pushing device, the positioning device used for positioning a product before bookbinding and the clamping and pushing device used for pushing the product into a bookbinding station are arranged on the bookbinding device; the clamping and pushing device comprises a pushing assembly used for pushing the products, a follow-up clamping assembly used for limiting and clamping the products and an adjusting assembly assisting in adjusting the follow-up clamping assembly, the pushing assembly and the adjusting assembly are installed on the binding device, and the follow-up clamping assembly is connected with the pushing assembly and the adjusting assembly. By means of the mode, by arranging the positioning device, products are aligned in all directions during binding, the binding effect is good, by arranging the pushing assembly and the follow-up clamping assembly, the products can be clamped and fixed while being pushed to the binding station, and the situation that the binding effect is poor due to displacement in the pushing process is avoided.

A preparation method of an extracellular vesicle drug delivery system belongs to the field of extracellular vesicles, and comprises the following steps: firstly, representing extracellular vesicles through a transmission electron microscope and a dynamic light scattering method, constructing a multi-dimensional feature matrix and calculating a stability coefficient; mixing the screened qualified vesicles with polyethylene glycol, and regulating and controlling the mixing process by adopting an online monitoring system; then adding chitosan and adjusting the pH value, and controlling process parameters through an intelligent automatic titration system; a targeting ligand is added for modification, and a high-throughput analysis system is adopted to evaluate the binding effect; after precise filtration sterilization and ultrafiltration centrifugal separation, a trehalose protective agent is added, finally, drying treatment is conducted through an intelligent freeze drying system, and a final product is obtained. The technical problem of unstable preparation quality caused by insufficient stability control in the preparation process of an extracellular vesicle drug delivery system in the prior art is solved.

The present invention discloses a cable product binding device, including a wire binding mechanism, a wire sleeve fixing mechanism, a wire tightening mechanism, and a wire holding mechanism arranged on a fixed plate. The wire binding mechanism is arranged on the right side of the fixed plate and is used for rotating the wire binding. The wire sleeve fixing mechanism is arranged on the right side of the wire binding mechanism and is used for fixing the binding wire sleeve. The wire tightening mechanism and the wire holding mechanism are both arranged on the left side of the fixed plate. The wire holding mechanism is used for fixing the cable harness. The wire tightening mechanism is used for fixing the binding wire end and performing the wire tightening operation after the wire binding is completed. The present invention is applicable to the technical field of cable products. By arranging the wire binding mechanism, the wire sleeve fixing mechanism, the wire tightening mechanism, and the wire holding mechanism, the cable product harness can be quickly bound. During the binding process, it is ensured that each circle of wire is evenly stressed when wrapped around the cable harness, and the binding effect is good. At the same time, the possibility of worker injury is reduced, and the device is safe and efficient.

The invention discloses a rapid hemostasis bandaging device for emergency treatment wounds, relates to the technical field of hemostasis bandaging instruments, and provides the following scheme that the rapid hemostasis bandaging device comprises a first-aid backpack, the front side of the first-aid backpack is connected with a bandaging disinfection mechanism, and the bottom surface of the bandaging disinfection mechanism is fixedly connected with a bandaging forceps mechanism. According to the scheme, the binding forceps mechanism and the binding and disinfecting mechanism are cooperatively matched, flexible opening and closing and stable fixing of the semi-annular grooves are achieved through hinging of forceps handles and the design of the torsional spring, and limb placement and operation are facilitated. The arrangement of the electromagnet is ingenious, the semi-annular strips are tightly connected when the semi-annular grooves are closed, the stability of the device in the binding process is ensured, and the binding effect is improved. The servo motor drives the semi-ring-shaped strip to do circular motion and is matched with the hemostatic bandage which is adhered to the limb in advance, so that the wound can be quickly and uniformly bound, and the time is saved. Atomizing nozzles are distributed in an annular array mode, wounds can be completely covered, and disinfectant is effectively sprayed for disinfection.

The invention relates to the technical field of biology, in particular to application of multi-ligand glycan-4 to regulation and control of intercellular function of macrophages and renal fibrosis. According to the application, the inhibitor for inhibiting the binding effect of the binding areas between the multi-ligand glycan-4 and the phagocytosis and cell movement protein 1 is used for preparing the accelerant for promoting the interburial function of the macrophages. The application is based on earlier-stage research finds that the platelet reaction protein 1 is combined with a multi-ligand glycan-4 receptor on the surface of macrophages, meanwhile, the platelet reaction protein 1 can promote combination between the multi-ligand glycan-4 and phagocytosis and cell movement protein 1, and the interburial function of the macrophages is inhibited. And an animal model of knocking down the multi-ligand glycan-4 can delay the progress of renal fibrosis. Therefore, the multi-ligand glycan-4 can regulate and control the cellular burial function of the macrophages and delay the process of renal fibrosis at the same time, and the blank that the cellular burial function of the targeted macrophages is applied to renal fibrosis treatment in the prior art is filled.

The invention discloses a buckle-free hairy crab binding machine, and relates to the technical field of binding machines. Comprising a machine body, an arc-shaped cover is fixedly installed on the machine body, a containing block is arranged in the arc-shaped cover, and a rope winding groove is formed in the containing block; an L-shaped frame plate is fixedly installed on the arc-shaped cover, an adjusting assembly is arranged on the L-shaped frame plate, a connecting transverse rod is arranged on the adjusting assembly, and a U-shaped frame plate is fixedly installed at the end of the connecting transverse rod. According to the crab binding machine, through effective cooperation of the adjusting assembly and the overturning assembly, it is ensured that crabs can be stably fixed in the containing block, potential safety hazards caused by manual pressing of workers are avoided, meanwhile, the crabs are prevented from being injured, the crabs can be automatically taken out of the containing block through the design of the lifting assembly, taking and placing work of operators is greatly facilitated, and the working efficiency is improved. And meanwhile, the position-adjustable wire feeding pipe is utilized to ensure that the tightness of the binding rope is moderate, so that the binding effect is improved, and the use effect of the binding machine is effectively improved.

This application discloses an immunoassay kit, its preparation method, and its application. The immunoassay kit includes a small peptide-coated solid-phase carrier, a bispecific antibody, and a labeled detection antibody. The bispecific antibody includes an anti-small peptide antibody and a linked capture antibody. The anti-small peptide antibody specifically binds to the small peptide, and both the capture antibody and the labeled detection antibody specifically bind to the target analyte and have different antigen recognition epitopes. The highly specific binding of the small peptide to the anti-small peptide antibody achieves efficient immobilization of the bispecific antibody, significantly improving antibody immobilization density and activity retention compared to traditional detection methods. The targeted binding effect of the bispecific antibody amplifies the detection signal while avoiding competitive interference from endogenous biotin, achieving highly sensitive and interference-resistant immunoassay.

The application discloses a well site pipe cable binding device and a binding control method. It relates to the technical field of in-situ leaching uranium well site cable and pipe material binding technology, and comprises a pipe cable embracing mechanism and a binding piece conveying mechanism connected with the end of the pipe cable embracing mechanism. The pipe cable is arranged in the pipe cable embracing mechanism. A driving mechanism is arranged on the pipe cable embracing mechanism. The binding piece conveying mechanism is used for driving the binding piece to move around the pipe cable in the circumferential direction under the driving of the driving mechanism, so that the pipe cable is fixed and bound. The application can improve the pipe cable binding efficiency and ensure the pipe cable binding effect.

The utility model relates to the technical field of carton nailing machines, and provides a semi-automatic carton nailing machine which comprises a base, a stand column fixed to one side of the top wall of the base, a top beam fixed to the top end of the stand column, a nailing head arranged at one end of the top beam and a supporting beam fixed to the side wall of the stand column. A motor used for driving the screw to rotate is fixed to the side wall of the stand column, a sliding block is screwed to the screw, and a top plate is fixed to the top end of the sliding block through a connecting mechanism. By means of the technical scheme, the problems that in the using process of an existing carton stapler, a carton is directly placed on a supporting beam, in the stapling process, the carton slides along the supporting beam, abrasion is likely to be caused, the service life of the carton is affected, and the service life of the carton is affected are solved. And meanwhile, the problem that the binding effect is affected due to the fact that the two ends of a carton are attached to each other manually in an existing carton stapler, and deviation is prone to occurring in the manual operation process is solved.

The application provides a display panel, a preparation method of the display panel and a display device. The display panel is used for binding connection with a driving chip. The display panel comprises a binding area. The display panel comprises a substrate, an organic layer and a plurality of conductive parts which are stacked on the substrate in the binding area. The plurality of conductive parts are arranged at a side of the organic layer away from the substrate. The organic layer has a avoiding opening. The orthographic projection of the conductive part on the organic layer coincides with at least part of the avoiding opening. The organic layer in the avoiding opening is removed, so that the organic layer under the conductive part is reduced, thereby reducing the deformation degree of the organic layer in the binding process. Therefore, the display panel, the preparation method of the display panel and the display device provided by the application can improve the binding effect of the display panel and the driving chip, thereby ensuring the display effect of the display panel and the display device.

This utility model discloses a feeder for a perfect binding machine. It relates to the field of perfect binding machine technology and includes a fixed assembly. The fixed assembly contains a moving assembly, which includes a moving base. The moving base has a fixed groove. Moving side plate assemblies and fixed side plate assemblies are respectively located on both sides of the fixed groove. The fixed side plate assembly includes a fixed clamping plate and a second telescopic rod. The fixed clamping plate is fixedly connected to one side of the fixed groove. A second limiting groove is provided on one side of the fixed clamping plate. A second lifting bar is slidably connected inside the second limiting groove. A second guide plate is fixedly installed on the top of the second lifting bar. A lifting block is fixedly installed at the output end of the second telescopic rod. This utility model allows for adjustment of the height of the moving side plate assembly and the fixed side plate assembly, enabling the device to clamp and fix pages of different widths, improving the perfect binding effect and possessing high practical value.

The application discloses a DNA nano antisense drug targeting microRNA, a preparation method and application thereof. The DNA nano antisense drug comprises a DNA nanostructure as a carrier, antisense peptide nucleic acid and selected aptamer, the DNA nanostructure wraps the antisense peptide nucleic acid, and exposes the selected aptamer, the antisense peptide nucleic acid is connected to the 3' end of a staple chain constituting the DNA nanostructure, and the selected aptamer is modified to the 5' end extended from another staple chain constituting the DNA nanostructure, and the antisense peptide nucleic acid can specifically recognize target microRNA in tumor cells. The DNA nano antisense drug has the advantages of simple preparation process, low price and harmless metabolic products, has strong specific binding effect on target microRNA and can promote cell apoptosis, and has great application value in the field of anticancer drug preparation.

The utility model relates to a handcart for battery transportation, include: support, at least one mounting piece and bandage, be provided with support piece on the support, and mounting piece is slidably arranged on the support piece, in use, the bandage is installed between the mounting plate and the mounting ring, and the mounting plate and the mounting ring can cooperate with each other to limit the position of the bandage, after placing the goods needing transportation on the support piece, according to the type and the size of the goods, the position of the mounting plate is slid, the position of the bandage can be adjusted flexibly, and then the bandage can be pulled to tighten the goods. Through the above setting, the position of the binding can be flexibly selected to realize the best binding effect, and then the stability during transportation is improved.

The present invention discloses a thin-walled antistatic flame-retardant light-diffusing PC material, which comprises the following components in percentage by weight: 95%-98% of PC resin, 1%-3% of antistatic agent, 0.1%-0.3% of flame retardant, 0.1%-0.3% of light diffusing agent, 0.1%-0.5% of antioxidant, and 0.1%-0.5% of lubricant. Among them, the antistatic agent is a n-butylphosphonium bis(trifluoromethanesulfonyl)imide salt ionic liquid type antistatic agent. This ionic antistatic agent has a better binding effect with the PC substrate. One end of it is firmly "buried" in the PC substrate, and the other end is close to the substrate surface, enabling the substrate to have a good permanent antistatic effect. At the same time, the ionic liquid antistatic agent of the present invention exhibits antistatic effect through ionic conductivity, and it can be not affected by the use environment. Even in a dry environment, it can exhibit excellent antistatic property; and this ionic liquid antistatic agent has a relatively high decomposition temperature, which can meet the requirements of co-extrusion and injection molding, making the preparation process of the PC material simpler and the cost lower.