136 results about "Skin permeability" patented technology

The invention provides a sustained-release microneedle for treating ill-conditioned pregnancy and a preparation method and application thereof, and relates to the technical field of biological medicines.The sustained-release microneedle for treating ill-conditioned pregnancy comprises a base and a needle tip on the base, the needle tip part of the gel microneedle is made of heparin medicine, and the needle tip part of the gel microneedle is made of gelatin. The heparin medicine comprises heparin, heparin sodium, low-molecular heparin, low-molecular heparin sodium or low-molecular heparin calcium; the needle point part comprises a heparin photo-crosslinking monomer, and the base comprises a biocompatible polymer matrix. The sustained-release microneedle for treating pathological pregnancy provided by the embodiment of the invention has good mechanical strength, skin permeability and anticoagulant activity, can reduce skin bruises caused by subcutaneous injection of heparin, improves abortion caused by infection and inflammation and abortion caused by APS (anti-phospholipid antibody syndrome), can realize sustained release of drugs and increase of drug loading capacity, and has good application prospects. Sustainable drug delivery is achieved, and frequent injection is avoided.

The invention relates to the technical field of pharmaceutical preparations, and provides a minoxidil film coating agent as well as a preparation method and application thereof. The minoxidil film coating agent provided by the invention comprises 40-60% of propylene glycol, 3-7% of polyvinyl alcohol, 20-30% of ethanol, 1-7% of minoxidil and the balance of water. According to the invention, propylene glycol is taken as a solvent, a plasticizer and a transdermal absorption enhancer, polyvinyl alcohol is taken as a film-forming material, and ethanol is taken as a volatile agent, after administration, ethanol is volatilized to promote film formation of polyvinyl alcohol, and propylene glycol enhances the plasticity of the formed film, so that the effect of reducing liquid medicine loss is achieved, the local medicine concentration is increased, and the bioavailability is improved. The minoxidil liniment disclosed by the invention has excellent skin permeability, can effectively convey a medicine to a required part, and can ensure that the medicine is released at a fixed position of the skin and is accurately administered in a medicine release process, so that the stimulation of liquid medicine flow to other parts is reduced, and a good treatment effect is achieved.

The invention discloses a compound fluralana external preparation for dogs, a preparation method and application, belongs to the technical field of veterinary drugs, and solves the problems that an existing preparation is poor in skin surface permeability, a solvent is easy to volatilize, and use experience and drug effect exertion are influenced. The preparation is prepared from the following raw materials: fluralana, moxidectin, ethyl butylacetamidopropionate and N, N-dimethylformamide. The preparation method comprises the following steps: adding N, N-dimethylacetamide, acetone, an auxiliary adjuvant, a transdermal penetration enhancer, an antioxidant and a surface film-forming agent; according to the invention, the combination of the fluralab and the moxidectin can play a synergistic effect and expand an anti-parasitic spectrum so as to achieve an internal and external driving effect; both the fluralab and the moxidectin belong to high-fat-soluble substances, parasites can be quickly repelled and killed by adding novel adjuvant natural parasite expelling ingredients, and meanwhile, the skin permeability can be improved by adding the efficient transdermal penetration enhancer, and the risk that medicine residues are licked by pets is reduced.

The invention belongs to the field of skin care and skin disease treatment, and provides a skin care composition and application thereof, and the skin care composition is in a liquid form and comprises recombinant collagen and glycolic acid. The specific low-concentration glycolic acid in the skin care composition disclosed by the invention ensures the mild keratin metabolism capability; the recombinant collagen with high transdermal property can quickly permeate into the deep layer of the skin, and can immediately provide a repairing raw material for the skin while the glycolic acid acts, so that discomforts such as redness and stabbing pain are remarkably relieved, and synchronous skin care and repairing is realized.

The invention belongs to the technical field of biological medicine, and particularly relates to hyaluronic acid nano-microspheres as well as a preparation method and application thereof. According to the preparation method of the hyaluronic acid nano-microspheres, the hyaluronic acid nano-microspheres are prepared through interaction of nucleic acid, basic amino acid and hyaluronate in a specific proportion, the preparation process is optimized, and the prepared hyaluronic acid nano-microspheres are high in hyaluronic acid adding amount, high in skin permeability and good in skin care effect. The stability is good, and the application requirements in transdermal drug delivery drugs, skin care products and other products are met. Meanwhile, a non-covalent binding mode is adopted for preparing the nano-microspheres, the preparation operation is simple, the gelling property of the hyaluronate is effectively improved, the sticky feeling under high content is improved, and the application scene of hyaluronic acid in the field of skin care products is widened.

The invention discloses a preparation method of anti-aging whitening skin cream based on traditional Chinese medicine exosome extraction, and relates to the technical field of cosmetics. Comprising the following steps: (1) raw material compatibility and pretreatment: taking 1-8 parts by mass of abelmoschus manihot exosome, 1-8 parts by mass of bighead atractylodes rhizome exosome, 1-8 parts by mass of bletilla striata exosome, 1-8 parts by mass of radix angelicae exosome, 1-8 parts by mass of white poria cocos exosome, 1-8 parts by mass of radix paeoniae alba exosome, 1-8 parts by mass of lily exosome, 1-8 parts by mass of silkworm larva exosome, 1-8 parts by mass of white asarum exosome and 1-8 parts by mass of cordyceps sinensis exosome; according to the skin care product disclosed by the invention, the exosome system of twelve traditional Chinese medicinal materials is applied to the field of skin care products for the first time; a complete traditional Chinese medicine exosome extraction, identification and preparation technology system is established; the exosome is used as a natural nano-carrier, so that the skin permeability of active ingredients is remarkably improved; based on the theory of complementing color with color in traditional Chinese medicine, traditional Chinese medicinal materials with white character heads are carefully selected; the exosomes of the medicinal materials have a synergistic effect, so that multi-target skin metabolism regulation is realized.

The invention belongs to the technical field of biological medicines, and particularly relates to application of a marine small molecule peptide and an active variant thereof in preparation of a medicine for treating skin diseases, the marine small molecule peptide and the active variant thereof can effectively inhibit keratinocyte pan apoptosis induced by TNF-alpha and IFN-gamma, the formation of a PANoptosome complex is blocked through a multi-target synergistic effect, and the effect of treating the skin diseases is achieved. The oxidative stress is reduced, and mitochondria is stabilized, so that a skin inflammatory cell death network is inhibited from the source. The variant has the same high sequence as the peptide, retains the activity of inhibiting cell pan-apoptosis, and has enhanced stability, skin permeability, in vivo half-life or efficacy. Based on the action mechanism, the peptide and the variant thereof can be used for preparing medicines for preventing and treating intractable skin diseases such as epidermis necrolysis, psoriasis, atopic dermatitis, skin lupus erythematosus and lichen planus. The invention also provides a composition containing the peptide or the variant thereof, and dosage forms comprise an external preparation and an injection.

The invention relates to a ginsenoside nano-micelle based on intermolecular self-assembly as well as a preparation method and application thereof, and belongs to the technical field of nano-micelles. The preparation process of the ginsenoside nano-micelle comprises the following steps: converting raw materials of panaxadiol saponin by using a compound enzyme, removing impurities by passing through a column, carrying out intermolecular self-assembly under ultrasonic, and purifying; the ginsenoside nano-micelle is prepared from ginsenoside Rg5, ginsenoside CK and ginsenoside Rg3, and the ginsenoside Rg5, the ginsenoside CK and the ginsenoside Rg3 are used as auxiliary materials. The ginsenoside nano-micelle is prepared in an intermolecular self-assembly mode, the water solubility and stability of ginsenoside are remarkably improved, the ginsenoside can be uniformly dispersed in a water solution and is not prone to precipitation and degradation, meanwhile, the skin permeability of the ginsenoside can be effectively improved through the nanoscale micelle structure, and the skin permeability of the ginsenoside can be effectively improved. Therefore, the skin care effect of the ginsenoside is fully exerted, and the ginsenoside is very suitable for being applied to skin care products.

The invention discloses a portable hot compress medicine carrying device for treating temporomandibular arthropathy, which comprises a main body part provided with a placing cavity; the medicine carrying assembly is arranged in the placing cavity; the ear hook is connected to the side of the main body part so as to be hung on the ear, so that the medicine carrying assembly faces the temporomandibular joint; the medicine carrying assembly comprises a medicine box, a sponge layer and a graphene heating layer, the sponge layer is arranged between the medicine box and the graphene heating layer, and liquid medicine in the medicine box is conveyed to the graphene heating layer arranged towards the temporomandibular joint through the sponge layer; the graphene heating layer is electrified to emit far infrared waves, so that blood circulation of the temporomandibular joint area is promoted through heat radiation, and percutaneous release of liquid medicine is enhanced. According to the medicine carrying device, through heat radiation of the graphene heating layer, local blood circulation of the temporomandibular joint is improved, skin permeability is improved, and medicine penetrates through the skin to enter subcutaneous tissue or muscular tissue.

The invention relates to a brightening composition for improving skin transparency and glossiness and application of the brightening composition, and belongs to the technical field of cosmetics. The brightening composition comprises oxyresveratrol, a loquat leaf extract, a burdock seed extract and a verbascos extract, the composition can effectively resist oxidation and inflammation through the oxyresveratrol so as to relieve skin darkness, and the loquat leaf extract can promote cell autophagy so as to remove metabolic waste and improve skin permeability. The burdock seed extract improves the epidermis structure so as to enhance the skin light transmission, and the verbascos extract plays a role in instant brightening through a quantum transition effect. According to the composition, through the synergistic effect of all the components, the skin transparency and glossiness are remarkably improved, and the composition is mild, free of irritation and suitable for being used by people with sensitive skin.

This invention provides a Panax notoginseng-Paris polyphylla supramolecular complex, its preparation method, cosmetic products, and applications. The Panax notoginseng-Paris polyphylla supramolecular complex is a complex formed by non-covalent bonding of Panax notoginseng extract (as the host molecule) and Paris polyphylla extract (as the guest molecule), with the host molecule encapsulating the guest molecule structure. The Panax notoginseng-Paris polyphylla supramolecular complex of this invention not only improves the water solubility of Paris polyphylla extract but also increases its skin permeability and reduces its cytotoxicity. The preparation method of this invention utilizes the synergistic effect of the active ingredients, resulting in strong compatibility and synergistic efficacy. It also slows down the release time of the active ingredients, extends their shelf life, and features a simple and easy-to-control process, stable granulation effect, and low production cost.

An iontophoresis device capable of reducing skin irritability due to an applied current while enhancing skin permeability of a drug is provided. The iontophoresis device includes a power supply, an electrode electrically connected to the power supply, a drug disposed between skin and the electrode, and a control unit configured to control a current applied to the skin via the electrode. The control unit controls the current so that a pulse current having a pulse frequency of 0.5 Hz or more and 50 Hz or less is applied to the skin.

The invention discloses an anti-wrinkle firming oil composition containing water-soluble polypeptide as well as a preparation method and application of the anti-wrinkle firming oil composition, and belongs to the technical field of cosmetics. The composition comprises the following components: vegetable fat, synthetic fat, skin feeling adjusting fat, an oil-soluble active component, an oil-soluble color mixing component, a surfactant, essence, a solvent and a water-soluble polypeptide active matter. Adding the water-soluble polypeptide active matter into a solvent, and dissolving to obtain an active matter solution; and mixing the vegetable fat, the synthetic fat, the oil-soluble active component and the skin feeling adjusting fat, adding the oil-soluble color adjusting component and the essence, stirring, adding the surfactant while stirring, and finally adding the active matter solution to obtain the anti-wrinkle firming composition. According to the invention, after the water-soluble active matter is wrapped by using a reverse micelle wrapping technology, the water-soluble active matter can be added into a pure oil system, and a pure oil product with good stability, skin permeability and anti-wrinkle and tightening effects is prepared.

The application relates to a film-forming composition containing an ionic liquid and a preparation method thereof, the film-forming composition is formed by a drug (API) with an active ingredient and a counter ion corresponding thereto or an API-ILs novel drug delivery system formed by two different API, can realize liquidization of a solid drug, improve the solubility, skin permeability and bioavailability of a poorly soluble drug, prevent the drug from being precipitated due to drug supersaturation after the film-forming composition is formed into a film on the surface of the skin, meanwhile, the composition has a good plasticizing effect on a film-forming polymer without adding a plasticizer, and the use of the traditional plasticizer can be avoided, and safety hidden dangers and toxicity caused by the use of the traditional plasticizer can be avoided.

The invention belongs to the technical field of recombinant collagen sequence analysis, and discloses a recombinant collagen sequence analysis method based on AI deep learning. Comprising the following steps: extracting a natural III-type collagen sequence; applying the natural III-type collagen sequence to the trained model to generate a thermodynamic diagram; generating an optimized natural III type collagen sequence based on the thermodynamic diagram; performing fine tuning on the AlphaFold2 model by using the fine tuning data set, and obtaining an integrated structure model by introducing spiral torsion constraint and hydroxyproline simulation parameters; loading the optimized natural III-type collagen sequence, and predicting the stability of the triple helix structure of the sequence through the structure model; and extracting a natural III-type collagen sequence which passes the stability detection, and outputting a report file by using a skin permeability prediction model to realize recombinant collagen sequence analysis based on AI deep learning.

The present invention relates to a composition comprising an anti-aging peptide and, more specifically, to an anti-aging cosmetic, food, and pharmaceutical composition comprising the anti-aging peptide. The anti-aging peptide according to the present invention not only exhibits excellent skin permeability, but also demonstrates remarkable antioxidant activity, wrinkle reduction, skin elasticity enhancement, collagenase inhibition, or hyaluronidase inhibition effects, as confirmed experimentally. These findings indicate that the anti-aging peptide of the present invention possesses excellent anti-aging activity and thus can be variously used as a functional material in pharmaceutical, medicinal, cosmetic, and food fields.

The application provides an adenosine co-crystal and a preparation method and application thereof, and belongs to the technical field of biological medicines.The adenosine co-crystal is formed by adenosine and ikar or nicotinamide according to a molar ratio of 1:0.2-16.9, and overcomes the problem of poor bioavailability of adenosine in the prior art.The adenosine co-crystal provided by the application has a significantly higher solubility compared with adenosine, can improve the blood drug concentration in vivo as a medicine to further play a more effective therapeutic role, can avoid the influence of the hydrophobicity of the stratum corneum to further improve the skin permeability of the product as a skin care product or a cosmetic product, and can improve the solubility of the effective component in the product to better play a hair growth effect as a hair growth product, and has wide application potential.The preparation method of the co-crystal has simple steps, high efficiency, low cost, and the advantages of being suitable for large-scale production.

The invention relates to the technical field of cosmetics or skin external preparations, in particular to a glucosylrutin-vitriol composition containing a supramolecular solvent and preparation and application thereof.The composition is prepared from, by mass, 25%-40% of the supramolecular solvent, 8%-10% of vitriol, 0.01%-0.5% of glucosylrutin, 0.1%-5% of an auxiliary additive, 0.01%-0.05% of an antioxidant, 0.4%-2% of 1, 2-pentanediol, 0.1%-0.5% of 1, 2-pentanediol, 0.1%-0.5% of a stabilizer and the balance water. 0.4-2% of 1, 2-hexanediol and the balance of deionized water; the supramolecular solvent comprises a hydrogen bond donor, a hydrogen bond acceptor and a functional cosolvent, the functional cosolvent comprises a deep eutectic solvent and a bio-based solvent, and the total addition amount of the functional cosolvent is 10-15% of the total mass of the hydrogen bond donor and the hydrogen bond acceptor. By optimizing component selection and matching process design, the composition has the advantages that the skin permeability is obviously improved, and the anti-wrinkle, firming and skin repairing effects are realized.

The application relates to a preparation method and application of royal jelly acid double-wrapped bodies, and belongs to the technical field of cosmetics. The royal jelly acid double-wrapped body prepared by the application is obtained by co-wrapping royal jelly acid by phospholipid lipids and hydroxypropyl-beta-cyclodextrin, and the double-wrapping system of the hydroxypropyl-beta-cyclodextrin and the liposome improves the loading capacity of the royal jelly acid, has good stability, can significantly improve the solubility of the royal jelly acid, and is convenient for application in cosmetics; compared with pure royal jelly acid, the royal jelly acid double-wrapped body prepared by the application has more excellent skin permeability and more excellent effect of improving the content of type IV collagen of skin, and can provide mechanical support for skin and maintain the young state of skin.

The invention discloses a composition containing an exosome loaded with hydroxyl pinacolone 9-cis-retinoate and application of the composition, and belongs to the technical field of cosmetic raw materials. The core components of the composition are the agilawood exosome loaded with hydroxyl pinacolone 9-cis-retinoate and the fibroin, and the composition forms a synergistic effect through the efficient delivery characteristic of the agilawood exosome and the film-forming moisturizing effect of the fibroin, so that the problems that the traditional retinol component is unstable, the skin permeability is poor and the irritation is strong are solved, and the composition has a good application prospect. The defects that in an existing exosome delivery technology, the compatibility of active ingredients is poor, and the exosome is prone to inactivation and difficult to reside on the skin surface are overcome, the deep permeation, slow release and targeting effects of hydroxypinacolone 9-cis-retinoate can be achieved, the tightening, anti-wrinkle, whitening and spot fading effects are remarkably improved, and skin irritation is reduced. Experiments prove that the tightening and anti-wrinkle essence prepared on the basis of the composition has an excellent skin improving effect.

The invention relates to a platinum compound-containing transdermal absorption type composition for delaying skin aging as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The invention provides a transdermal absorption type composition containing a platinum compound, which can obviously improve the skin permeability of the olive leaf extract, so that active substances can more easily penetrate through the cuticle and the corium layer to play a role, and the active ingredients are ensured to be absorbed and utilized by the skin to the maximum extent. Furthermore, the active ingredients in the transdermal absorption type composition are scientifically proportioned, the skin resistance is improved through antioxidation and anti-inflammation, a regeneration environment is created through moisturizing and barrier repair, and finally, structural rejuvenation is realized through collagen stimulation, so that a defense-repair-regeneration multi-dimensional synergistic network is formed, and the skin regeneration effect is improved. The effects of promoting permeation of functional components, moisturizing, repairing, tightening, resisting aging and delaying skin aging are doubly improved.

It relates to a composition, the use of the composition for preparing a topical external formulation or a cosmetic, and a method for preparing the composition. The composition comprises a linear saturated dicarboxylic acid and a polyaspartic acid or derivatives thereof, wherein the content of the polyaspartic acid or derivatives thereof is greater than or equal to 0.01% based on the total weight of the composition. The solubility of the linear saturated dicarboxylic acid (e.g., azelaic acid) in aqueous solutions can be increased by using the linear saturated dicarboxylic acid (e.g., azelaic acid) in combination with the polyaspartic acid or derivatives thereof. It can thus have improved skin permeability, for example when used in a cosmetic, thereby exerting its efficacy to a greater extent.

The invention provides low-irritation nicotine gel as well as a preparation method and application thereof. The nicotine gel comprises a gel matrix and an exosome compound embedded in the gel matrix, the gel matrix is prepared from the following components: pullulan and water; the exosome compound comprises a pomegranate exosome and nicotine loaded in the pomegranate exosome. According to the pomegranate exosome, the nicotine is coated in the pomegranate exosome, so that the stability of the nicotine can be effectively improved, the skin permeability of the nicotine is enhanced, and the abstinence symptom occurring during smoking cessation is relieved; pulullan is used as a medium, the skin absorption effect of nicotine is further regulated and controlled, and the situation that the smoking cessation effect is affected by too fast or too slow absorption is avoided.

The invention discloses a compound nysfungin ointment, which comprises an active component, a preservative, a humectant, a thickening agent, a grease matrix and an antibacterial agent, the active component is selected from one or more of self-made mycotoxin, neomycin sulfate, permethrin and triamcinolone acetonide, the preservative is selected from benzalkonium chloride, the humectant is selected from glycerol, the thickening agent is selected from glycerol, and the grease matrix is selected from a grease matrix. The humectant is selected from humectant, the thickening agent is selected from carbomer, the grease matrix is selected from liquid paraffin and / or wool fat, the antibacterial agent is selected from thymol, and the ratio of the humectant to the thickening agent is (2-7): (0.5-3) in parts by mass. By accurately controlling the proportion of the humectant to the thickener, the texture of the ointment can be optimized, so that the skin permeability is improved, the medicine absorption is promoted, the treatment effect is improved, in addition, the form of the ointment can be kept, the active ingredients are prevented from being degraded, and the shelf life of the preparation is prolonged.

The application relates to the technical field of pharmaceutical preparations, and provides an ivermectin external pharmaceutical composition, a preparation method and application.The ivermectin external pharmaceutical composition is mainly composed of ivermectin, a permeation enhancer combination, oil ingredients, an emulsifier, a viscosity regulator and a carrier; the ivermectin content is 0.60%-1.00% w / w; the permeation enhancer combination is a combination of diethylene glycol monoethyl ether, decyl umbelliferrone polyoxyethylene ether 8 and farnesol, and the content is 10%-15% w / w.The application overcomes the defects of the prior art, the composition not only has improved skin permeability and retention, but also is stable and non-greasy, and meanwhile, the production process has scalability, and can ensure uniform dispersion of active ingredients and auxiliary materials.

The invention relates to the technical field of cosmetic raw material / product efficacy evaluation, in particular to a skin brightening efficacy evaluation system and application thereof. The invention provides a skin brightening effect evaluation system, which comprises a skin permeability effect evaluation module, a skin orderliness effect evaluation module and a human body brightening effect evaluation module, can systematically, scientifically, objectively and accurately evaluate the brightening effect of cosmetic effect raw materials / products, and can further form a cosmetic industry brightening effect evaluation standard. In addition, cosmetic raw materials / products with the skin brightening effect can be scientifically, objectively, conveniently and accurately screened out according to the skin brightening effect evaluation system. The skin brightening effect evaluation system can also be applied to a cosmetic composition / formula design method, and a development thought and a reference standard can be provided for cosmetic composition / formula design.

The invention discloses a multi-target synergistic anti-wrinkle firming beauty makeup composition as well as a preparation method and application of the multi-target synergistic anti-wrinkle firming beauty makeup composition. The technical defects that an existing polypeptide product is single in effect, low in permeability and poor in stability are effectively overcome. The composition takes acetyl hexapeptide-8, palmitoyl tripeptide-1 and decapeptide-4 as core active components, is compounded with auxiliary materials such as a humectant, a penetration enhancer, a stabilizer and a preservative, and is prepared by compounding according to a specific mass percent. The action mechanisms of'inhibiting dynamic wrinkles, promoting collagen synthesis and protecting a collagen structure 'of the three polypeptides are complementary, so that multi-target synergistic anti-wrinkle is realized; the skin permeability is improved by means of plant-derived ceramide NP, and the polypeptide stability is enhanced through dithiothreitol and pH regulation. The invention can be widely applied to beauty makeup products such as essence, face cream, eye cream and the like.

The invention provides a transdermal absorption composition containing six active peptides and application of the transdermal absorption composition. The transdermal absorption composition is prepared from 0.5 to 5 parts of acetyl hexapeptide-8, 0.5 to 5 parts of decapeptide-4, 0.5 to 5 parts of oligopeptide-1, 1 to 10 parts of glycoprotein, 1 to 8 parts of serum protein, 5 to 20 parts of soluble collagen, 3 to 12 parts of mannitol, 2 to 10 parts of trehalose, 1 to 5 parts of caprylyl glycol and 5 to 25 parts of butanediol. The composition is used for preparing transdermal absorption products for improving ovarian functions and delaying ovarian aging. Through a penetration enhancer combination and raw material modification process, the technical problems that polypeptide is difficult to transdermal and easy to inactivate are effectively solved, and the skin permeability and stability of active ingredients are improved, so that the ovarian function is improved through synergistic interaction.

The present application relates to the technical field of medical and cosmetic compounds, and particularly relates to a double supramolecular VC nicotinamide@AA2G package and a preparation method and application thereof, the preparation method of the double supramolecular VC nicotinamide@AA2G package uses vitamin C and nicotinamide as precursors, synthesizes a supramolecular VC nicotinamide co-crystal through a supramolecular modification reaction, and uses hydroxypropyl-beta-cyclodextrin to wrap the supramolecular VC nicotinamide co-crystal and ascorbic acid glucoside, so as to obtain the double supramolecular VC nicotinamide@AA2G package. The double supramolecular package prepared by the method can improve the stability of vitamin C, improve the skin permeability, ensure the original whitening effect of vitamin C and nicotinamide, and fully play the role of inhibiting melanin. Meanwhile, the double supramolecular package has good antioxidant property, greatly improves the bioavailability, and enhances the stability and application effect.