202 results about "Skin permeability" patented technology

The invention provides a sustained-release microneedle for treating ill-conditioned pregnancy and a preparation method and application thereof, and relates to the technical field of biological medicines.The sustained-release microneedle for treating ill-conditioned pregnancy comprises a base and a needle tip on the base, the needle tip part of the gel microneedle is made of heparin medicine, and the needle tip part of the gel microneedle is made of gelatin. The heparin medicine comprises heparin, heparin sodium, low-molecular heparin, low-molecular heparin sodium or low-molecular heparin calcium; the needle point part comprises a heparin photo-crosslinking monomer, and the base comprises a biocompatible polymer matrix. The sustained-release microneedle for treating pathological pregnancy provided by the embodiment of the invention has good mechanical strength, skin permeability and anticoagulant activity, can reduce skin bruises caused by subcutaneous injection of heparin, improves abortion caused by infection and inflammation and abortion caused by APS (anti-phospholipid antibody syndrome), can realize sustained release of drugs and increase of drug loading capacity, and has good application prospects. Sustainable drug delivery is achieved, and frequent injection is avoided.

The invention relates to the technical field of pharmaceutical preparations, and provides a minoxidil film coating agent as well as a preparation method and application thereof. The minoxidil film coating agent provided by the invention comprises 40-60% of propylene glycol, 3-7% of polyvinyl alcohol, 20-30% of ethanol, 1-7% of minoxidil and the balance of water. According to the invention, propylene glycol is taken as a solvent, a plasticizer and a transdermal absorption enhancer, polyvinyl alcohol is taken as a film-forming material, and ethanol is taken as a volatile agent, after administration, ethanol is volatilized to promote film formation of polyvinyl alcohol, and propylene glycol enhances the plasticity of the formed film, so that the effect of reducing liquid medicine loss is achieved, the local medicine concentration is increased, and the bioavailability is improved. The minoxidil liniment disclosed by the invention has excellent skin permeability, can effectively convey a medicine to a required part, and can ensure that the medicine is released at a fixed position of the skin and is accurately administered in a medicine release process, so that the stimulation of liquid medicine flow to other parts is reduced, and a good treatment effect is achieved.

The invention discloses a compound fluralana external preparation for dogs, a preparation method and application, belongs to the technical field of veterinary drugs, and solves the problems that an existing preparation is poor in skin surface permeability, a solvent is easy to volatilize, and use experience and drug effect exertion are influenced. The preparation is prepared from the following raw materials: fluralana, moxidectin, ethyl butylacetamidopropionate and N, N-dimethylformamide. The preparation method comprises the following steps: adding N, N-dimethylacetamide, acetone, an auxiliary adjuvant, a transdermal penetration enhancer, an antioxidant and a surface film-forming agent; according to the invention, the combination of the fluralab and the moxidectin can play a synergistic effect and expand an anti-parasitic spectrum so as to achieve an internal and external driving effect; both the fluralab and the moxidectin belong to high-fat-soluble substances, parasites can be quickly repelled and killed by adding novel adjuvant natural parasite expelling ingredients, and meanwhile, the skin permeability can be improved by adding the efficient transdermal penetration enhancer, and the risk that medicine residues are licked by pets is reduced.

The invention provides a nicotine-containing gel and a preparation method thereof. The nicotine-containing gel comprises the following components: a nicotine microcapsule, a penetrant, a gel matrix, a flavoring agent and water. The gel has excellent biocompatibility and slow release performance through combination of the nicotine microcapsules and the gel matrix, the skin permeability of nicotine can be improved by adding the penetrant, and the gel has the advantages of freshening the oral cavity and keeping fragrance for a long time by adding the flavoring agent. Therefore, a new consumption choice can be provided for smoking cessation groups and patients needing nicotine medicine.

The invention discloses a supported hyaluronic acid particle, a cosmetic, a preparation method and an application. The preparation method comprises the following steps: S1, carrying out ultrasonic treatment on a hyaluronic acid aqueous solution and a cationic polymer solution, and drying to obtain powder; and S2, in the presence of a buffer solution and a cross-linking agent, carrying out a cross-linking reaction on the powder and the effective components, and carrying out ball milling to prepare the supported hyaluronic acid particles. According to the method, the surface of the hyaluronic acid is coated with the cationic polymer, the active ingredients are loaded, the loaded hyaluronic acid particles are prepared through ball milling and are in a corner angle shape, the skin permeability can be remarkably improved, the stability of the loaded active ingredients is improved, and meanwhile the dual effects of moisturizing and skin barrier strengthening of the hyaluronic acid are achieved. According to the cosmetic containing the supported hyaluronic acid particles, the active ingredients can stably exist under various conditions, and the activity can maintain the stability for a long time.

The invention belongs to the field of skin care and skin disease treatment, and provides a skin care composition and application thereof, and the skin care composition is in a liquid form and comprises recombinant collagen and glycolic acid. The specific low-concentration glycolic acid in the skin care composition disclosed by the invention ensures the mild keratin metabolism capability; the recombinant collagen with high transdermal property can quickly permeate into the deep layer of the skin, and can immediately provide a repairing raw material for the skin while the glycolic acid acts, so that discomforts such as redness and stabbing pain are remarkably relieved, and synchronous skin care and repairing is realized.

This invention belongs to the field of cosmetic technology, specifically a glycyrrhizin-based composite nanoparticle containing sclerotherapy, BPOXY, and collagen, along with its preparation method and applications. The invention first combines glycyrrhizin and glycyrrhizic acid via non-covalent bonds to obtain a glycyrrhizin-glycyrrhizic acid eutectic structure that overcomes the solubility problem of glycyrrhizin. Then, a BPOXY-collagen mixture is used to coat the glycyrrhizin-glycyrrhizic acid eutectic structure, yielding glycyrrhizin-based composite nanoparticles containing sclerotherapy, BPOXY, and collagen. The glycyrrhizin-based composite nanoparticles containing sclerotherapy, BPOXY, and collagen obtained using this method exhibit good water solubility of glycyrrhizin, a simple composition, high stability, and minimal risk of allergic reactions. Furthermore, it enhances the skin permeability of glycyrrhizin, collagen, and BPOXY, resulting in a synergistic effect and improved bioavailability.

The invention belongs to the technical field of biological medicine, and particularly relates to hyaluronic acid nano-microspheres as well as a preparation method and application thereof. According to the preparation method of the hyaluronic acid nano-microspheres, the hyaluronic acid nano-microspheres are prepared through interaction of nucleic acid, basic amino acid and hyaluronate in a specific proportion, the preparation process is optimized, and the prepared hyaluronic acid nano-microspheres are high in hyaluronic acid adding amount, high in skin permeability and good in skin care effect. The stability is good, and the application requirements in transdermal drug delivery drugs, skin care products and other products are met. Meanwhile, a non-covalent binding mode is adopted for preparing the nano-microspheres, the preparation operation is simple, the gelling property of the hyaluronate is effectively improved, the sticky feeling under high content is improved, and the application scene of hyaluronic acid in the field of skin care products is widened.

The invention discloses a preparation method of anti-aging whitening skin cream based on traditional Chinese medicine exosome extraction, and relates to the technical field of cosmetics. Comprising the following steps: (1) raw material compatibility and pretreatment: taking 1-8 parts by mass of abelmoschus manihot exosome, 1-8 parts by mass of bighead atractylodes rhizome exosome, 1-8 parts by mass of bletilla striata exosome, 1-8 parts by mass of radix angelicae exosome, 1-8 parts by mass of white poria cocos exosome, 1-8 parts by mass of radix paeoniae alba exosome, 1-8 parts by mass of lily exosome, 1-8 parts by mass of silkworm larva exosome, 1-8 parts by mass of white asarum exosome and 1-8 parts by mass of cordyceps sinensis exosome; according to the skin care product disclosed by the invention, the exosome system of twelve traditional Chinese medicinal materials is applied to the field of skin care products for the first time; a complete traditional Chinese medicine exosome extraction, identification and preparation technology system is established; the exosome is used as a natural nano-carrier, so that the skin permeability of active ingredients is remarkably improved; based on the theory of complementing color with color in traditional Chinese medicine, traditional Chinese medicinal materials with white character heads are carefully selected; the exosomes of the medicinal materials have a synergistic effect, so that multi-target skin metabolism regulation is realized.

The invention belongs to the technical field of biological medicines, and particularly relates to application of a marine small molecule peptide and an active variant thereof in preparation of a medicine for treating skin diseases, the marine small molecule peptide and the active variant thereof can effectively inhibit keratinocyte pan apoptosis induced by TNF-alpha and IFN-gamma, the formation of a PANoptosome complex is blocked through a multi-target synergistic effect, and the effect of treating the skin diseases is achieved. The oxidative stress is reduced, and mitochondria is stabilized, so that a skin inflammatory cell death network is inhibited from the source. The variant has the same high sequence as the peptide, retains the activity of inhibiting cell pan-apoptosis, and has enhanced stability, skin permeability, in vivo half-life or efficacy. Based on the action mechanism, the peptide and the variant thereof can be used for preparing medicines for preventing and treating intractable skin diseases such as epidermis necrolysis, psoriasis, atopic dermatitis, skin lupus erythematosus and lichen planus. The invention also provides a composition containing the peptide or the variant thereof, and dosage forms comprise an external preparation and an injection.

The invention provides a dual ceramide essence inclusion. The dual ceramide essence inclusion is prepared from the following components in parts by weight: 1-6 parts of an active ingredient, 2-8 parts of an amphiphilic inclusion material and 40-70 parts of a microbe-derived vesicle material, wherein the active ingredients comprise ceramide NS / ceramide NG and ceramide AS; the amphiphilic inclusion material comprises the active component to form nanoparticles; the nanoparticle is wrapped by the microbe-derived vesicle material to form a ceramide / amphiphilic inclusion material / vesicle compound. The invention further provides a preparation method and application of the dual ceramide essence inclusion. The dual ceramide essence inclusion provided by the invention is high in stability and good in skin permeability, and has good repairing and anti-aging effects.

The invention discloses infantile massage oil with the effects of strengthening the spleen and nourishing the stomach and a preparation method thereof. The infantile massage oil with the effects of strengthening the spleen and nourishing the stomach is prepared from the following raw materials in parts by weight: 8 to 12 parts of fructus evodiae, 8 to 12 parts of radix aucklandiae, 8 to 12 parts of fried malt, 8 to 12 parts of rhizoma atractylodis, 4 to 8 parts of fried semen raphani, 15 to 25 parts of fructus amomi and 3 to 7 parts of fried endothelium corneum gigeriae galli. According to the infantile massage oil with the spleen-tonifying and stomach-nourishing effects, the working principles that the skin permeability is high, the medicine can be absorbed percutaneously, the medicine metabolism is fast, retention is avoided, the medicine can easily pass through a blood brain barrier, and the medicine effect can enter meridians and collaterals are utilized; through a three-in-one scheme of'compound compatibility design-carrier synergism-low-sensitivity matrix optimization ', the effects of tonifying the spleen and nourishing the stomach are achieved, the effect is good, and the effect taking speed is high.

The invention provides a glabridin micro-emulsion, a glabridin micro-emulsion mask liquid and a preparation method, and relates to the technical field of cosmetics. The glabridin microemulsion provided by the invention is prepared from the following raw materials: glabridin, tween-80, 1, 2-hexanediol, ethyl oleate and water, and the mass ratio of the glabridin to the tween-80 to the 1, 2-hexanediol to the ethyl oleate to the water is (0.25 to 2.5) to (12.5 to 25) to (12.5 to 50) to (5 to 12.5) to 19. According to the glabridin microemulsion, 1, 2-hexanediol is used as a surfactant, tween-80 is used as a cosurfactant, ethyl oleate is used as an oil phase, glabridin is wrapped in the microemulsion, the solubility and skin permeability of glabridin can be improved, and cosmetics can efficiently play skin care functions such as whitening and relieving. The invention provides a glabridin micro-emulsion mask liquid which has good whitening, moisturizing and soothing effects.

The invention relates to a ginsenoside nano-micelle based on intermolecular self-assembly as well as a preparation method and application thereof, and belongs to the technical field of nano-micelles. The preparation process of the ginsenoside nano-micelle comprises the following steps: converting raw materials of panaxadiol saponin by using a compound enzyme, removing impurities by passing through a column, carrying out intermolecular self-assembly under ultrasonic, and purifying; the ginsenoside nano-micelle is prepared from ginsenoside Rg5, ginsenoside CK and ginsenoside Rg3, and the ginsenoside Rg5, the ginsenoside CK and the ginsenoside Rg3 are used as auxiliary materials. The ginsenoside nano-micelle is prepared in an intermolecular self-assembly mode, the water solubility and stability of ginsenoside are remarkably improved, the ginsenoside can be uniformly dispersed in a water solution and is not prone to precipitation and degradation, meanwhile, the skin permeability of the ginsenoside can be effectively improved through the nanoscale micelle structure, and the skin permeability of the ginsenoside can be effectively improved. Therefore, the skin care effect of the ginsenoside is fully exerted, and the ginsenoside is very suitable for being applied to skin care products.

The invention discloses a portable hot compress medicine carrying device for treating temporomandibular arthropathy, which comprises a main body part provided with a placing cavity; the medicine carrying assembly is arranged in the placing cavity; the ear hook is connected to the side of the main body part so as to be hung on the ear, so that the medicine carrying assembly faces the temporomandibular joint; the medicine carrying assembly comprises a medicine box, a sponge layer and a graphene heating layer, the sponge layer is arranged between the medicine box and the graphene heating layer, and liquid medicine in the medicine box is conveyed to the graphene heating layer arranged towards the temporomandibular joint through the sponge layer; the graphene heating layer is electrified to emit far infrared waves, so that blood circulation of the temporomandibular joint area is promoted through heat radiation, and percutaneous release of liquid medicine is enhanced. According to the medicine carrying device, through heat radiation of the graphene heating layer, local blood circulation of the temporomandibular joint is improved, skin permeability is improved, and medicine penetrates through the skin to enter subcutaneous tissue or muscular tissue.

The invention relates to a brightening composition for improving skin transparency and glossiness and application of the brightening composition, and belongs to the technical field of cosmetics. The brightening composition comprises oxyresveratrol, a loquat leaf extract, a burdock seed extract and a verbascos extract, the composition can effectively resist oxidation and inflammation through the oxyresveratrol so as to relieve skin darkness, and the loquat leaf extract can promote cell autophagy so as to remove metabolic waste and improve skin permeability. The burdock seed extract improves the epidermis structure so as to enhance the skin light transmission, and the verbascos extract plays a role in instant brightening through a quantum transition effect. According to the composition, through the synergistic effect of all the components, the skin transparency and glossiness are remarkably improved, and the composition is mild, free of irritation and suitable for being used by people with sensitive skin.

This invention provides a Panax notoginseng-Paris polyphylla supramolecular complex, its preparation method, cosmetic products, and applications. The Panax notoginseng-Paris polyphylla supramolecular complex is a complex formed by non-covalent bonding of Panax notoginseng extract (as the host molecule) and Paris polyphylla extract (as the guest molecule), with the host molecule encapsulating the guest molecule structure. The Panax notoginseng-Paris polyphylla supramolecular complex of this invention not only improves the water solubility of Paris polyphylla extract but also increases its skin permeability and reduces its cytotoxicity. The preparation method of this invention utilizes the synergistic effect of the active ingredients, resulting in strong compatibility and synergistic efficacy. It also slows down the release time of the active ingredients, extends their shelf life, and features a simple and easy-to-control process, stable granulation effect, and low production cost.

The invention provides a nano-emulsion composition, a nano skin care product, a preparation method and application, the nano-emulsion composition comprises a nano-emulsion and nucleic acid loaded on the surface of the nano-emulsion, and the nano-emulsion comprises a functional component, an emulsifier, an emollient, an antioxidant, a humectant and water; the functional component comprises a barrier repair lipid, the barrier repair lipid comprises sphingolipid, the sphingolipid comprises phytosphingosine, and the barrier repair lipid further comprises one or more of ceramide, free fatty acid and cholesterol; the mass ratio of the nucleic acid in the nanoemulsion composition is 0.1%-0.6%. The nanoemulsion composition has excellent permeability, so that the skin permeability of the nucleic acid is improved, and the bioavailability of the nucleic acid is improved; meanwhile, the nucleic acid can be specifically bound with adenosine A2A receptors distributed on keratinocytes, so that the binding speed of the nano-emulsion and the cells can be increased, the absorption and action effects of the nano-emulsion are specifically promoted, and the resistance of the skin to light aging is improved.

An iontophoresis device capable of reducing skin irritability due to an applied current while enhancing skin permeability of a drug is provided. The iontophoresis device includes a power supply, an electrode electrically connected to the power supply, a drug disposed between skin and the electrode, and a control unit configured to control a current applied to the skin via the electrode. The control unit controls the current so that a pulse current having a pulse frequency of 0.5 Hz or more and 50 Hz or less is applied to the skin.

The present invention relates to a percutaneous absorption preparation for relieving pain and, more specifically, to a percutaneous absorption preparation having enhanced drug absorption efficacy. Every ingredient in the percutaneous absorption preparation according to the present invention is uniformly dispersed and does not aggregate, and thus a sufficient anti-inflammatory and pain-relieving efficacy of the drug can be continuously exhibited over a long period of time. In addition, the drug is percutaneously delivered in an amount sufficient for exhibiting efficacy while minimizing skin irritation, which is a disadvantage of percutaneous absorption preparations, and thus a high level of pain-relieving efficacy is exhibited. Moreover, skin penetration promotion in which a consistent amount of percutaneous drug absorption is sustained over a long period of time can be achieved, and thus side effects such as the hepatic first-pass effect in the body can be prevented.

The invention discloses an anti-wrinkle firming oil composition containing water-soluble polypeptide as well as a preparation method and application of the anti-wrinkle firming oil composition, and belongs to the technical field of cosmetics. The composition comprises the following components: vegetable fat, synthetic fat, skin feeling adjusting fat, an oil-soluble active component, an oil-soluble color mixing component, a surfactant, essence, a solvent and a water-soluble polypeptide active matter. Adding the water-soluble polypeptide active matter into a solvent, and dissolving to obtain an active matter solution; and mixing the vegetable fat, the synthetic fat, the oil-soluble active component and the skin feeling adjusting fat, adding the oil-soluble color adjusting component and the essence, stirring, adding the surfactant while stirring, and finally adding the active matter solution to obtain the anti-wrinkle firming composition. According to the invention, after the water-soluble active matter is wrapped by using a reverse micelle wrapping technology, the water-soluble active matter can be added into a pure oil system, and a pure oil product with good stability, skin permeability and anti-wrinkle and tightening effects is prepared.

The application relates to a film-forming composition containing an ionic liquid and a preparation method thereof, the film-forming composition is formed by a drug (API) with an active ingredient and a counter ion corresponding thereto or an API-ILs novel drug delivery system formed by two different API, can realize liquidization of a solid drug, improve the solubility, skin permeability and bioavailability of a poorly soluble drug, prevent the drug from being precipitated due to drug supersaturation after the film-forming composition is formed into a film on the surface of the skin, meanwhile, the composition has a good plasticizing effect on a film-forming polymer without adding a plasticizer, and the use of the traditional plasticizer can be avoided, and safety hidden dangers and toxicity caused by the use of the traditional plasticizer can be avoided.

The invention belongs to the technical field of recombinant collagen sequence analysis, and discloses a recombinant collagen sequence analysis method based on AI deep learning. Comprising the following steps: extracting a natural III-type collagen sequence; applying the natural III-type collagen sequence to the trained model to generate a thermodynamic diagram; generating an optimized natural III type collagen sequence based on the thermodynamic diagram; performing fine tuning on the AlphaFold2 model by using the fine tuning data set, and obtaining an integrated structure model by introducing spiral torsion constraint and hydroxyproline simulation parameters; loading the optimized natural III-type collagen sequence, and predicting the stability of the triple helix structure of the sequence through the structure model; and extracting a natural III-type collagen sequence which passes the stability detection, and outputting a report file by using a skin permeability prediction model to realize recombinant collagen sequence analysis based on AI deep learning.

The invention relates to the technical field of skin care products. The invention aims to provide the composition containing cycloastragenol and oligopeptide. The preparation method comprises the following steps: A1, preparing a stock solution; a2, fermenting for the first time; a3, packaging the oligopeptide; a4, carrying out secondary fermentation; and A5, carrying out secondary filtration. The target product contains rich oligopeptide and cycloastragenol, has the characteristics of both oligopeptide and cycloastragenol, is good in skin permeability and high in human body absorption rate, can effectively activate the activity of skin cells, and can be widely popularized and applied in anti-aging skin care products. The whole production steps are simplified by adopting a microbial fermentation mode, the fermentation conversion efficiency of oligopeptide products produced by bacillus licheniformis in a substrate can be effectively ensured by adopting alkaline fermentation for the first time, and the fermentation conversion efficiency of cycloastragenol produced by aspergillus niger in the substrate can be fully exerted by secondary acidic fermentation. The whole production links of oligopeptide and cycloastragenol are integrated while effective fermentation target product output is guaranteed, and large-scale production is facilitated.

The present invention relates to a composition comprising an anti-aging peptide and, more specifically, to an anti-aging cosmetic, food, and pharmaceutical composition comprising the anti-aging peptide. The anti-aging peptide according to the present invention not only exhibits excellent skin permeability, but also demonstrates remarkable antioxidant activity, wrinkle reduction, skin elasticity enhancement, collagenase inhibition, or hyaluronidase inhibition effects, as confirmed experimentally. These findings indicate that the anti-aging peptide of the present invention possesses excellent anti-aging activity and thus can be variously used as a functional material in pharmaceutical, medicinal, cosmetic, and food fields.

The invention provides multi-coated ceramide nanoparticles as well as a preparation method and application thereof, and relates to the technical field of medicines and cosmetics. The multi-coated ceramide nanoparticle provided by the invention comprises a ceramide liposome and a polymer layer for coating the ceramide liposome, the ceramide liposome comprises ceramide and a liposome for coating the ceramide, and the liposome is a lipid bilayer formed by phospholipid and cholesterol. The ceramide is subjected to multiple wrapping, the ceramide can be protected from being damaged by the external environment through wrapping of the lipidosome, and the skin permeability of the ceramide is improved to a certain degree; polymer wrapping provides an additional protection layer, and the stability is enhanced. According to the multi-coated ceramide provided by the invention, the stability, the permeability and the effect of the ceramide are remarkably improved by combining the liposome, the nanoparticles and the microcapsule, so that the ceramide can permeate into a corium layer or a deeper part to play a role.

The application provides an adenosine co-crystal and a preparation method and application thereof, and belongs to the technical field of biological medicines.The adenosine co-crystal is formed by adenosine and ikar or nicotinamide according to a molar ratio of 1:0.2-16.9, and overcomes the problem of poor bioavailability of adenosine in the prior art.The adenosine co-crystal provided by the application has a significantly higher solubility compared with adenosine, can improve the blood drug concentration in vivo as a medicine to further play a more effective therapeutic role, can avoid the influence of the hydrophobicity of the stratum corneum to further improve the skin permeability of the product as a skin care product or a cosmetic product, and can improve the solubility of the effective component in the product to better play a hair growth effect as a hair growth product, and has wide application potential.The preparation method of the co-crystal has simple steps, high efficiency, low cost, and the advantages of being suitable for large-scale production.

The invention relates to an ozagrel derivative as well as a preparation method and application thereof. The preparation method of the ozagrel derivative or the salt thereof comprises the following steps: carrying out acyl chloride reaction on ozagrel and an acyl chloride reagent to prepare a first intermediate; and carrying out acylation reaction on the first intermediate and dialkylamino alcohol to prepare the ozagrel derivative. The ozagrel derivative has good skin permeability and can exert a good drug effect.

The present invention relates to a moisturizing and whitening composition that promotes osmotic absorption and its use in skin care products. The composition contains permeation enhancers such as phospholipid polyethylene glycol carboxyl, limonene, and menthone. By optimizing the composition and ratio of the permeation enhancers, the skin permeability of phytoestrogens is significantly enhanced. After four hours of use, skin care products prepared with this composition maintain skin moisture content above 60%. They also demonstrate excellent whitening and elasticity enhancement, with significant increases in skin brightness (ΔL) and a skin elasticity growth rate exceeding 26% after five weeks of use. This composition addresses the issue of low phytoestrogens' low permeation efficiency, achieving long-lasting moisturizing and whitening effects. It also offers a positive user experience, is non-irritating, and has broad market application prospects.

The invention relates to the technical field of cosmetics or skin external preparations, in particular to a glucosylrutin-vitriol composition containing a supramolecular solvent and preparation and application thereof.The composition is prepared from, by mass, 25%-40% of the supramolecular solvent, 8%-10% of vitriol, 0.01%-0.5% of glucosylrutin, 0.1%-5% of an auxiliary additive, 0.01%-0.05% of an antioxidant, 0.4%-2% of 1, 2-pentanediol, 0.1%-0.5% of 1, 2-pentanediol, 0.1%-0.5% of a stabilizer and the balance water. 0.4-2% of 1, 2-hexanediol and the balance of deionized water; the supramolecular solvent comprises a hydrogen bond donor, a hydrogen bond acceptor and a functional cosolvent, the functional cosolvent comprises a deep eutectic solvent and a bio-based solvent, and the total addition amount of the functional cosolvent is 10-15% of the total mass of the hydrogen bond donor and the hydrogen bond acceptor. By optimizing component selection and matching process design, the composition has the advantages that the skin permeability is obviously improved, and the anti-wrinkle, firming and skin repairing effects are realized.