382 results about "Skin permeability" patented technology

A high throughput screening and isolation system identifies rare enhancer mixtures from a candidate pool of penetration enhancer combinations. The combinations are screened for high penetration but low irritation potential using a unique data mining method to find new potent and safe chemical penetration enhancer combinations. The members of a library of chemical penetration enhancer combinations are screened with a high throughput device to identify “hot spots”, particular combinations that show higher chemical penetration enhancement compared to neighboring compositions. The irritation potentials of the hot spot combinations are measured to identify combinations that also show low irritation potential. A active component, such as a drug, is then combined with the combination in a formulation which is tested for the ability of the drug to penetrate into or through skin. It is then assessed whether the formulation can deliver the quantity of drug required, and animal tests are conducted to confirm in vivo the ability of the chemical penetration enhancer combinations to facilitate transport of sufficient active molecules across the skin to achieve therapeutic levels of the active molecule in the animal's blood. The invention provides specific unique and rare mixtures of chemical penetration enhancers that enhance skin permeability to hydrophilic macromolecules by more than 50-fold without inducing skin irritation, such as combinations of sodium laurel ether sulfate and 1-phenyl piperazine, and combinations of N-lauryl sarcosine and Span 20/sorbitan monolaurate.

Preparations for percutaneous absorption comprising a basic drug or its salt dissolved in a liquid component and having an enhanced percutaneous absorbability and a safety to the skin, i.e., the administration site. The preparations for percutaneous absorption, preferably patches, contain a basic drug or its salt, an organic acid or its salt and a liquid component having a solubility parameter of from 7 to 13 (cal/cm³)^1/2 and a have a very excellent skin permeability of the drug.

Topical alcoholic or aqueous alcoholic gels containing ibuprofen or other NSAIDs, such as, naproxen, in substantially neutral salt form, have enhanced penetration through skin and may provide rapid pain/inflammation relief by including in the formulation 2-n-nonyl-1,3-dioxolane or other hydrocarbyl derivative of 1,3-dioxolane-or 1,3-dioxane or acetal, as skin penetration enhancing compound. The amount of propylene glycol may be varied to adjust the initial flux of the NSAID through the skin, especially for ibuprofen, naproxen, and ketorolac.

Methods of treating tissue with fractional laser radiation are disclosed. The fractional laser treatment methods reversibly increase skin permeability while maintaining a substantially intact stratum corneum and producing alterations within the epidermis and dermis. The alterations in the epidermis and dermis can include necrosis and/or coagulation. The alterations in the epidermis can include the creation of a plurality of pores in the stratum corneum and/or the creation of vacuoles in the layers of the epidermis below the stratum corneum. The fractional laser treatment methods disclosed herein can be used to provide treatments to the skin, to increase permeation of active substances into or through tissue, to deliver active substances locally or systemically, and to control the delivery of active substances.

The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.

Provided is a transdermal preparation having low skin irritation as well as a sufficient skin permeability rate of donepezil, which comprises one or more drugs selected from donepezil and pharmaceutically acceptable salts thereof. Also provided are a manufacturing method thereof, and a method for reducing skin irritation of a transdermally absorbable donepezil-containing preparation. An embodiment is a transdermal preparation comprising one or more drugs selected from donepezil and pharmaceutically acceptable salts thereof, and a skin irritation-reducing agent.

A pharmaceutical composition for external use which is an organogel containing a fatty acid ester and a glycerolglycerin fatty acid ester, in particular, a novel transdermally absorbable pharmaceutical composition for external use which has a drug such as non-narcotic analgesics as an active ingredient made in organogel form containing a drug such as non-narcotic analgesics as an active ingredient, a fatty acid ester and a glycerolglycerin fatty acid ester, and a method for producing the composition. The pharmaceutical composition significantly improves skin permeability of drugs such as non-narcotic analgesics and allows a sufficient amount of drug to permeate the skin sustainably. Moreover, since the pharmaceutical composition is in organogel form, it can be easily applied to a preparation in practice. In addition, the pharmaceutical composition can provide efficient use and the like of drugs due to a high drug release rate and therefore is highly useful.

The invention discloses a restoring serum and a preparing method thereof, and is aimed at providing the serum which can effectively improve the skin permeability, balance the water storage, improve the skin shielding function and relieve and resist inflammation. The restoring serum is technologically characterized by comprising glycerinum or butanediol, erythritol or trehalose, sodium hyaluronate,a natural plant restoring factor, rona care ectoin, a water//butanediol//amino acid compound, a water//lactobacillus/soybean fermentation product extract//butanediol and other components. The invention belongs to the technical field of cosmetics.

Provided is a fentanyl transdermal patch comprising an acrylic-rubber hybrid as a drug-adhesive layer. The fentanyl transdermal patch can maintain constant fentanyl skin permeability for three days by maintaining close contact with the skin such that desorption, release by moisture and sweat, and skin stimulation are all improved.

An external preparation containing the following components (A), (B), (C), and (D):

• • (A) a non-steroidal analgesic/anti-inflammatory agent,
  • (B) a terpene and/or an essential oil containing a terpene,
  • (C) a higher alcohol, and
  • (D) a polyoxyalkylene alkyl ether and/or a polyoxyalkylene alkenyl ether. The external preparation of the present invention has improved skin permeation, and can thus be effective at a low concentration, and also has excellent appearance.

The invention discloses moisturizing lotion for repairing skin barriers and resisting free radicals. The moisturizing lotion comprises, in weight percent, 2%-6% of polyhydric alcohols, 0.2%-3% of thickening suspending agents, 1%-5% of natural squalane, 2.5%-4.5% of emulsifying agents, 0.1%-3% of ceramide NP, 0.1%-5% of nicotinamide, 0.1%-2% of lycopene, 0.5%-3% of grape seed extracts, 0.1%-1% of ferulic acid, 0.1%-2% of coenzyme Q10, 0.1%-2% of vitamin E and the balance water. By the aid of the proportion and combination of different components, a novel local treatment formula can be developedaccording to skin lesion relevant to a plurality of cuticles and skin damage and resistance of the free radicals. The components in the formula are necessary components forming skin permeability barriers and have synergistic interaction between antioxidant components, the skin barriers can be repaired, protection films are formed on the surfaces of skins, the moisturizing lotion resists oxidationand the free radicals, damage of external factors to the skins is avoided, transepidermal water loss rate is effectively reduced, and the moisturizing lotion has good moisturizing effects on the skins.

The invention relates to the field of cosmetics and provides a co-conveying nano composition of phenylethyl resorcinol. The co-conveying nano composition comprises phenylethyl resorcinol, other skin whitening active components, a nano medicine carrier as well as solvent complex lipid and water, wherein the phenylethyl resorcinol accounts for 0.1-10% of the total mass of the co-conveying nano composition; the other skin whitening active components comprise at least one of an antioxidant, a cutin peeling type active substance, a melanosome transferring inhibition active substance, an anti-glycation active substance and an anti-allergic agent; the nano medicine carrier comprises raw materials of an emulsifier, a Anti-allergic agent and polyhydric alcohols. Due to compounding of different skinwhitening components and carrying of the nano medicine carrier, a remarkable synergetic effect can be achieved, irritation of high-concentration phenylethyl resorcinol can be remarkably reduced, andthe co-conveying nano composition is good in stability, excellent in skin whitening effect, good in water solubility, good in skin permeability and widely applicable to cosmetics.

The present invention relates to a composition and a method for preparing a liposome, the liposome including a lipid bilayer and an aqueous core contains a hydrophobic or a hydrophilic drug and a component—Vitamin E derivative (d-α tocopheryl polyethylene glycol 1000 succinate; TPGS). TPGS is able to increase the encapsulation efficiency of drug in liposome as well as to enhance the stability of drug in liposomes. Such liposome is capable to increase the skin permeation of drugs. The preparation method comprises the following steps: (1) adding the drug to a Vitamin E derivative solution to form a mixture; and (2) adding at least one phosphatidyl choline to the mixture, after hydration from either sonication or homogenization.

The micro emulsified cosmetic for making skin fair and delicate has granularity of 1-100 nm, and consists of arbutin 0.10-3.00 wt%, surfactant 10.00-48.00 wt%, oil 1.00-20.00 wt%, proper amount of humectant, emollient, essence and preservative, and distilled water for the rest. The cosmetic with micro emulsified matrix has excellent transdermal permeability, increased effective component solubility, raised spreading property, and excellent cool and moistened feeling.

The present invention provides an external preparation which can improve a skin permeability of a hydrophilic medicine such as NSAID so that the medicine can act directly on a diseased area without passing through gastrointestinal tract or mucosa. The S/O type external preparation external preparation excellent in percutaneous absorbability of the present invention comprises a medicine-containing complex dissolved or dispersed in an oil phase, wherein the complex contains a hydrophilic medicine covered with a surfactant and is in a form of a solid.

Disclosed are compositions for skin care and their medicinal uses. The compositions are identical in lipid constituents and structural properties to that of human stratum corneum. They comprise the major constituents for the lipid lamellar of the stratum corneum, including ceramides, cholesterol and fatty acids, the major constituents for epidermal cell membranes, including phospholipids, and physiologically active substances, including phytosphingosine and its derivatives. Without causing side effects, the cream composition for skin care is of much better skin penetration and water-retention capacity than are conventional compositions comprised of ceramide and other components in forms different from those of human skin. In addition to providing inhibitory activity against skin microorganisms, the cream composition brings about an improvement in the wrinkle condition of the skin, so that it can be applied to cosmetics. Also, it can be used as a medicinal material for the therapeutic treatment of inflammation, such as thermic erythema caused by IR and/or UV light.

The invention relates to a finasteride nano-liposome and a preparation method thereof. The finasteride nano-liposome comprises finasteride, phospholipids, a flexible material and a PBS solution, wherein the weight percentage of the finasteride accounting for the phospholipids is 2.5% to 10%, the weight percentage of the flexible material accounting for the phospholipids is 20% to 50%, and the weight percentage of the PBS solution accounting for the phospholipids is 2.5% to 10%. According to the finasteride nano-liposome, the disadvantage, such as poor percutaneous permeability, of the finasteride is improved, the phospholipids and the flexible material are taken as a carrier system, and the prepared finasteride nano-liposome is simple to operate and good in repeatability and prevents from using an organic solvent with large toxicity, drugs are delivered to skin deep layers by using high deformability and efficient permeability of the flexible nano-liposome, and a better therapeutic effect is exerted.

The invention discloses a microemulsion containing vitamin C and vitamin E, wherein the continuous phase of the microemulsion comprises vitamin C 0.1-25.0%, vitamin E 0.1-2.0%, and the matrix of the microemulsion comprises surface active agent 9.0-48.0%, oil 1.0-20.0%, and water 40.0-89.0%.

Compositions are provided for the topical treatment of cancer consisting of lotions, creams, sprays, suppositories or slow-release transdermal patches containing lipid-soluble, skin-penetrating organic selenium compounds in combination with inert carriers in therapeutically effective amounts of selenium compound. The selenium compounds are medium linear chain dialkyl diselenides and precursors such as alkyl selenols. Preferred compositions employ R—Se—Se—R compounds where R is from 6 to 8 carbon atoms, and most specifically di-n-hexyl diselenide. Commonly used carriers may be purified hydrocarbon fractions, oils, with or without added fat-soluble vitamins, water and emulsifying agents.

Provided is a methylphenidate patch preparation superior in the stability of a drug (methylphenidate and/or a salt thereof) in the patch preparation, skin permeability of a drug during use of the patch preparation, and methylphenidate availability. A patch preparation having a support and an adhesive layer formed on at least one surface of the support, wherein the adhesive layer contains methylphenidate and/or a salt thereof, polyisobutylene and a liquid plasticizer. The liquid plasticizer preferably has an HLB value of 1.0-3.3.