5 results about "Phosphatidyl choline" patented technology

The present invention is concerned with materials and methods for the production of genetically modified plants, particularly where the plants are for the production of at least one unsaturated or polyunsaturated fatty acid. The Invention is also concerned with identification of genes conveying an unsaturated fatty acid metabolic property to a plant or plant cell, and generally relates to the field of phosphotidylcholine:diacylglycerol cholinephosphotransferase (PDCT).

This invention belongs to the pharmaceutical field, specifically relating to the application of phosphopamine hydrochloride in the preparation of drugs for treating preeclampsia. The application of phosphopamine hydrochloride in the preparation of drugs for treating preeclampsia involves the phosphopamine hydrochloride exerting its effect by promoting trophoblast motility. This effect is achieved by regulating the lactation modification of α-actin-4. The phosphopamine hydrochloride salvages trophoblast functional damage in preeclampsia by inhibiting lactation at the ACTN4 K346 site. This invention reveals for the first time that the lactation modification at the ACTN4 protein K346 site is abnormally elevated in placental tissue of PE patients. This modification can impair trophoblast function and drive disease progression. Phosphopamine hydrochloride can target and inhibit lactation modification at this site, reversing trophoblast functional damage and demonstrating good therapeutic potential.

Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment compriseswherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

The invention relates to the technical field of biological medicines, and discloses a free radical capture type phospholipid-like material, which has the following structural general formula: sn-1 and sn-2 positions are ester bonds; the hydrophilic group at the head of the phospholipid is phosphatidylcholine, R1 is an aliphatic chain and R2 is a free radical capture group, or R1 is a free radical capture group and R2 is an aliphatic chain. The invention also discloses a free radical capture type liposome for reducing the cardiotoxicity of doxorubicin. The free radical capture type liposome comprises the free radical capture type phospholipid-like material, phospholipid, cholesterol, phospholipid-polyethylene glycol, a pH regulating molecule, an auxiliary drug-loading molecule, an isotonic regulating molecule and an active drug. The liposome can be used for preparing medicines for treating tumors such as bladder cancer, breast cancer and ovarian cancer, the cardiotoxicity of adriamycin is remarkably reduced while the anticancer efficacy of adriamycin is ensured, and the liposome has good clinical application value.