The application relates to the field of biological
medicine, and particularly relates to a
cold storage solution and application of a combined
traditional Chinese medicine compound biological
stent drug delivery system in
eardrum repair. The
cold storage solution comprises a basic solution and L-alanyl-L-
glutamine; the basic solution comprises a STEEN solution. The
cold storage solution can promote
metabolism and synthesis of
glutathione of fat grafts, regulate ROS mitochondrial
oxidative stress, reduce cold storage damage of the fat grafts, and improve the cold storage quality of the fat grafts. Meanwhile, the application uses Shengji Yuhong
collagen sponge which contains an important classical prescription for promoting repair, forms a functional biological material with supporting and pro-angiogenic effects, forms a linkage mode of "double-stage regulation before and after
transplantation", closely combines the actual difficulties of
cell damage of fat groups and reduction of repair success rate caused by long
eardrum repair time in the clinic, explores a brand-new research mode for improving the
eardrum repair scheme, and has far-reaching
clinical significance.