121 results about "Erectile dysfunction" patented technology

The invention provides a stem cell exosome composition for treating erectile dysfunction and application thereof, the stem cell exosome composition comprises stem cell exosome and vasoactive intestinal peptide, and the amino acid sequence of the vasoactive intestinal peptide is shown as SEQ ID NO: 2. The amino acid structure of the vasoactive intestinal peptide is modified, so that the biological stability can be improved; the vasoactive intestinal peptide is combined with the adipose-derived mesenchymal stem cell exosome for use, so that the ED symptom can be relieved; the vasoactive intestinal peptide and the adipose tissue-derived stem cell exosome are combined for use, so that the expression level of cell factors can be adjusted, and the microenvironment of penis tissues can be improved.

The present invention relates to melanocortin-4 receptor agonists. More specifically, the present invention relates to a compound of Formula 1, a pharmaceutical composition comprising the compound as an active ingredient, and a use thereof, and the compound of the present invention exhibits excellent agonist activity against the melanocortin-4 receptor, and can be particularly used for the prevention or treatment of obesity, diabetes, inflammation, and erectile dysfunction.

In one embodiment, the present invention provides a device, wherein the device comprises a skin patch, configured to attach to the skin surface of the perineum of a subject suffering from premature ejaculation, wherein the skin patch contains electrodes configured to deliver electrical impulses transcutaneously to the bulbcavernosus muscle of the subject, wherein the transcutaneously delivered electrical impulses are configured to treat premature ejaculation.

The present invention relates to a compound exhibiting excellent agonist activity against melanocortin receptors. More specifically, the present invention relates to a compound of Formula 1, a pharmaceutical composition comprising the compound as an active ingredient, and a use thereof, and the compound of the present invention exhibits excellent agonist activity against melacortin-4 receptors and can be particularly useful in preventing or treating obesity, diabetes, inflammation and erectile dysfunction.

The invention relates to an extraction and culture method of urine-derived stem cells, and belongs to the field of cell biology and regenerative medicine. The method comprises the following steps: coating a culture plate with a gelatin solution; collecting clean midstream urine of healthy people and adding antibiotics; centrifugally separating the cell precipitate; washing with a phosphate buffer solution; re-suspending the precipitate by using a urine stem cell complete culture medium for primary culture; and after the cells grow to a certain fusion degree, carrying out passage amplification. The urine stem cell complete medium comprises a basic medium, fetal calf serum, epidermal growth factors, platelet-derived growth factors and basic fibroblast growth factors. By adopting the method disclosed by the invention, the urine-derived stem cells can be efficiently and stably separated from urine, and the obtained cells have high multiplication capacity, good stemness maintaining capacity, multidirectional differentiation potential and immunoregulation function, and can provide an ideal seed cell source for treating diseases such as diabetic erectile dysfunction.

The invention provides a novel pharmaceutical composition comprising sildenafil and cabergoline and method of use thereof for treating erectile dysfunction and / or male hypogonadism.

The invention relates to haptoglobin or a nucleic acid encoding haptoglobin for use in treating or preventing of exaggerated erectile response and / or preventing permanent erectile dysfunction. In addition, the invention relates a pharmaceutical composition for use in treating or preventing exaggerated erectile response and / or preventing permanent erectile dysfunction, wherein the pharmaceutical composition comprises an adeno-associated viral (AAV) vector with a transgene encoding a haptoglobin gene. The exaggerated erectile response may be priapism, for example priapism associated with sickle cell disease (SCD).

There is provided a composition for topical application to the penis for the treatment of erectile dysfunction, the composition being free of glyceryl trinitrate (GTN), sildenafil and an acetylcholinesterase inhibitor, and comprising volatile and non-volatile solvents, the volatile solvents comprising a lower alcohol and water and the non-volatile solvents comprising a polyhydric alcohol and a glycol. Preferably, the composition does not contain any pharmaceutically active ingredients for the treatment of erectile dysfunction. Also provided is a method of determining the cooling ability of a test composition, such as the composition described above.

An implantable system for treatment of climacturia has an inflatable penile implant and an inflatable cuff that is implantable around at least a portion of a urethra. A pump is operatively coupled to the penile implant and to the cuff to inflate the penile implant in treating erectile dysfunction and to inflate the cuff in treating climacturia.

This invention belongs to the field of traditional Chinese medicine, specifically relating to a topical delay spray and its preparation method. The invention uses the dried epidermis of the Huaxi toad (with the toad venom removed), and extracts it efficiently through a combination of water and alcohol extraction. Male silkworm moth oil can nourish and strengthen the body, tonify the liver and kidneys, and combat fatigue; studies have shown that male silkworm moth oil can effectively treat kidney yang deficiency. This invention combines the synergistic effects of toad skin extract and male silkworm moth oil to prepare a delay spray that can significantly treat premature ejaculation and erectile dysfunction in men. This preparation has the advantages of direct action, sustained release, avoidance of drug contact, and simple operation. This invention further improves the rational utilization system of toad resources, provides a practical solution for the efficient development of toad medicinal resources, and significantly reduces production and clinical application costs.

The invention relates to a crystal form of a compound shown as a formula I or a pharmaceutically acceptable salt thereof and a preparation method of the crystal form of the compound shown as the formula I or the pharmaceutically acceptable salt thereof. The compound of the formula I or the pharmaceutically acceptable salt thereof is used for treating cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, heart failure, pulmonary arterial hypertension (WHO levels I, II, III, IV), angina pectoris, thrombus, restenosis, myocardial infarction, stroke, cardiac insufficiency, fibrosis, pulmonary hyperplasia, erectile dysfunction, asthma, chronic kidney disease, diabetes, and the like. The composition can be used for treating liver cirrhosis, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome, acute lung injury, pulmonary fibrosis, cystic fibrosis or interstitial lung disease.

The present invention provides a pharmaceutical composition for preventing and treating avian white crown disease, belonging to the technical field of chicken breeding. The pharmaceutical composition of the present invention is prepared by mixing 10 to 30 parts of Morin hydrate, 5 to 20 parts of artemisinic acid, 5 to 20 parts of quinic acid, and 5 to 20 parts of ginsenoside total saponin sulfate derivatives. It can effectively improve the phenomena of a sharp drop in egg production rate, an increase in soft-shell eggs, and an increase in mortality rate of sick laying hens in cages, so that the egg production rate, egg quality, and lean meat content can be restored to normal levels; enhance the disease resistance of poultry, reduce stress reactions caused by factors such as drastic changes in temperature and microbial invasion, and improve the immunity of animal bodies; the dosage is small and the curative effect is significant. The high-dose oral liquid of the pharmaceutical composition prepared by the present application was used to feed sick chickens, and the effective rate of treatment reached 100%, and the cure rate reached 94.00%.

Microparticles that contain miRNA that controls the production of nitric oxide and are an agent for promoting the production of nitric oxide are new microparticles that enable controlling the expression of a protein and / or a gene related to erectile dysfunction; a preventive drug or a therapeutic drug for erectile dysfunction; a method for improving erectile dysfunction; it is preferable that the microparticles be exosomes; and it is preferable that the microparticles of the present invention contain miRNA targeting a gene concerning the expression of nitric oxide synthase as the miRNA that controls the production of nitric oxide, and be an agent for promoting the expression of nitric oxide synthase.

A transdermal treatment for erectile dysfunction includes an aqueous solution having a plurality of excipients and a combination of papaverine, phentolamine mesylate and prostaglandin E1.

The present invention discloses an SSR marker primer combination for identifying Leymus chinensis germplasm resources and its application. The present invention provides an SSR marker primer combination for identifying Leymus chinensis germplasm resources, which consists of 20 pairs of SSR primers. The present invention also provides an application of the SSR marker primer combination for identifying Leymus chinensis germplasm resources in constructing a molecular identity card of Leymus chinensis germplasm resources and identifying Leymus chinensis germplasm resources, and identifies 105 Leymus chinensis germplasm resources through the constructed molecular identity card of grass germplasm resources. The present invention provides a technical basis for the protection of Leymus chinensis germplasm resources, the authenticity identification of varieties, the identification of the kinship of germplasm resources and biological breeding.

The invention relates to therapeutic compositions, solid oral dosage forms, and methods for treating, preventing, or alleviating lower urinary tract symptoms (LUTS), benign prostatic hyperplasia (BPH), erectile dysfunction (ED), urinary incontinence, bladder obstruction, overactive bladder (OAB), underactive bladder, interstitial cystitis, prostatitis, bladder and prostate inflammation, prostate fibrosis or pelvic pain. The therapeutic compositions can comprise cranberry powder enriched in cranberry seeds or cranberry seed meal.

The invention provides application of lactobacillus reuteri to improvement of prostatitis and erectile dysfunction. The bacterial strain is lactobacillus reuteri NHNK-2001, the lactobacillus reuteri NHNK-2001 is preserved in the China Center for Type Culture Collection on April 25, 2024, and the preservation number of the lactobacillus reuteri NHNK-2001 is CCTCC (China Center for Type Culture Collection) NO: M 2024800. The NHNK-2001 has the functions of generating L-citrulline, repairing aged vascular endothelial cells, promoting vasodilation, repairing aged prostate cells and reducing prostatitis, and can be used for preparing products for improving prostatitis and erectile dysfunction.

The present invention relates to a crystalline form I represented by Formula 1, which may be characterized by XRD patterns, DSC profiles, and / or TGA profiles, a method for preparing the same, and a pharmaceutical composition comprising the same, useful for the treatment of prevention of obesity, diabetes, inflammation, or erectile dysfunction. (see formula 1) wherein R1 is C2-C5 alkyl.

A genetically modified mesenchymal stem cell including an exogenous nucleic acid including a Klotho encoding region operably linked to a promoter or promoter / enhancer combination, wherein the genetically modified mesenchymal stem cell exhibits increased Klotho expression compared to an unmodified mesenchymal stem cell. Also disclosed are methods of treating a patient including administering a therapeutically effective number of the genetically modified mesenchymal stem cells to the patient. The methods of treatment include treating the patient for a neurodegenerative disease; cancer; organ fibrosis; renal disease; age-related changes of organs or organ systems; to slow, reverse and / or inhibit aging; arteriosclerosis; dementia; diabetes mellitus; erectile dysfunction; autoimmune diseases or autoimmune-related diseases; an inflammatory disease of the lung and sepsis.

The invention belongs to the technical field of traditional Chinese medicine ointment preparation, and discloses a traditional Chinese medicine ointment patch for treating bone symptoms and a preparation process. The traditional Chinese medicine plaster for treating bone symptoms is prepared from the following raw materials: rheum officinale, ground beeltle, radix achyranthis bidentatae, radix clematidis, pangolin, monkey bone, schizophragma integrifolium, myrrh, rhizoma cibotii, ligusticum wallichii, pawpaw, uncaria, sargentgloryvine stem, asarum, cinnamon, semen strychni, poria cocos, radix paeoniae alba, radix angelicae, dragon's blood, cottonrose hibiscus leaves, frankincense, vegetable oil and red lead. The traditional Chinese medicine plaster for treating bone symptoms can be used for various muscle strain lesions, can be used for various traumatic injuries, fractures, tendon and vessel contracture and the like, and can also be used for symptoms such as arthritis, scapulohumeral periarthritis, cervical spondylosis and hyperostosis; the traditional Chinese medicine has the effects of promoting blood circulation to remove blood stasis, relieving swelling and pain, relaxing tendons and regulating qi, dispelling cold and wind and promoting reunion of fractured tendons and bones, takes effect quickly and does not cause adverse reaction easily.

The invention relates to a traditional Chinese medicine composition for treating damp-heat downward flow type erectile dysfunction. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3-9 parts of radix gentianae, 1-3 parts of centipede, 5-10 parts of earthworm, 3-9 parts of fructus cnidii, 3-9 parts of radix et rhizoma rhei, 3-9 parts of radix angelicae sinensis, 3-9 parts of radix rehmanniae recen, 3-9 parts of bupleurum chinense, 6-15 parts of semen plantaginis, 3-9 parts of caulis clematidis armandii, 3-9 parts of rhizoma alismatis, 15-30 parts of poria cocos and 10-30 parts of herba epimedii. According to the pathogenesis characteristics of damp-heat downward flow type, especially erectile dysfunction caused by stasis obstruction caused by damp-heat accumulation in bladder and prostate, the radix gentianae liver purging decoction is adopted as a basic formula, and the traditional Chinese medicine is prepared through addition and subtraction. All the medicines are compatible, the effects of clearing damp-heat in lower jiao and soothing liver and vibrating yang are further enhanced compared with a basic formula, and the whole formula has the effects of clearing heat and promoting diuresis, promoting blood circulation to remove meridian obstruction and soothing liver and eliminating wilt together.

Disclosed in the present invention are a method and composition for improving reproductive health and related use thereof in preparing nutritional products, health-care products, foods, beverages, animal feeds, or drugs for improving reproductive health. The method and composition of the present invention can improve erectile dysfunction, increase testosterone level, ameliorate hypogonadism, and ameliorate decreased sexual desire.

The invention discloses a preparation method of an epimedium extract and the epimedium extract and application thereof. The preparation method comprises the following steps: ultrasonically extracting epimedium in a solvent, collecting an organic phase and an aqueous phase after the extraction, and drying the organic phase after decompression concentration to obtain an epimedium extract A; adding water-saturated n-butanol to the aqueous phase for extraction, collecting the n-butanol phase after the extraction, and drying the n-butanol phase epimedium extract B; enzymolyzing the extract A to obtain an epimedium enzymolysate; acid-hydrolyzing the extract B to obtain an epimedium acid hydrolysate; and uniformly mixing the enzymolysis product and the acid hydrolysate to obtain an epimedium extract C. The extract A prepared by the invention mainly contains icariin, and the extract B mainly contains epimedin C; the yield of icariin II in the enzymatic hydrolysate is 40.19-86.25%, and the yield of dehydrated icariin in the acid hydrolysate is 61.27-77.51%. The epimedium extract C has obvious anti-fatigue and erectile dysfunction treatment effects.

To provide a new male climacteric disorder-ameliorating composition using a safe material free from side effects, and to provide a medicine, food and drink containing the composition.SOLUTION: The male climacteric disorder-improving composition contains a treated product of an Agaricus fruit body.SELECTED DRAWING: Figure 13

The invention discloses treatment equipment for reducing positive incisal margin after radical prostate resection, which comprises an injection device for injecting a PSMA probe into a body, a PET / CT (positron emission tomography / computed tomography) imaging device, a near-infrared fluorescence imaging device and a surgical robot, and is characterized in that the near-infrared fluorescence imaging device displays fluorescence levels of tumor tissues and normal tissues of the prostate of a patient injected with the probe; and carrying out fluorescence imaging on the prostate tumor tissue according to the fluorescence intensity of the probe in the urine. The treatment equipment disclosed by the invention is used for carrying out fluorescence imaging and accurate positioning on tumor tissues in an excision operation, the surgical robot is used for accurately excising the tumor tissues under fluorescence navigation, and the postoperative excision edge positive rate is obviously reduced; after the treatment equipment is adopted to carry out radical prostate resection, the biochemical recurrence risk of a patient is obviously reduced, and the prognosis is good; in addition, complications such as erectile dysfunction, urinary incontinence and urethrostenosis caused by injury of nerve and blood vessel bundles in an operation can be avoided, and the influence on the postoperative life quality of a patient is remarkably reduced.

The massage device using the fabric that is the article of the design is a massage device used in response to social needs, such as the need to treat erectile dysfunction through precise stimulation, alleviate insomnia and lower back pain, and prevent suicide through the euphoria caused by precise stimulation of the groin. This massage device is constructed by sewing together an outer fabric and an inner fabric with cushion holders, offset from each other to the left and right. The article has a pair of slits cut above and below the cushion holder in the outer fabric, and a pair of slits cut above and below the cushion holder in the inner fabric from the opposite direction to the outer fabric, allowing the cushion holder to be folded back between the pair of slits in the outer and inner fabrics. When the two cushion holders are folded back, an insertion opening is formed in the center. When used by a man, the penis is inserted into the insertion opening, the folded cushion is placed in close contact with the groin, and pressure is applied to the folded cushion, allowing for a groin massage.

There is provided a composition for topical application to the penis for the treatment of erectile dysfunction, the composition being free of glyceryl trinitrate (GTN), sildenafil and an acetylcholinesterase inhibitor, and comprising volatile and non-volatile solvents, the volatile solvents comprising a lower alcohol and water and the non-volatile solvents comprising a polyhydric alcohol and a glycol. Preferably, the composition does not contain any pharmaceutically active ingredients for the treatment of erectile dysfunction. Also provided is a method of determining the cooling ability of a test composition, such as the composition described above.

The invention provides a traditional Chinese medicine composition for treating type 2 diabetic erectile dysfunction and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The composition is prepared from radix bupleuri, radix paeoniae alba, radix rehmanniae preparata, Chinese yam, fructus corni, cortex moutan, poria cocos, rhizoma alismatis, herba cistanche, centipede, flos carthami, cortex eucommiae, radix angelicae sinensis and liquorice root. Clinical research proves that the total treatment effective rate of the traditional Chinese medicine composition reaches 78.13% which is obviously superior to 28.13% of a control group, the IIEF-5 score can be obviously improved, the traditional Chinese medicine symptoms can be improved, the effect on the aspects of improving sexual confidence and sexual nature indexes, reducing time worry and other psychological indexes is outstanding, and meanwhile the adverse drug reaction occurrence rate is not obviously different from that of the control group. The traditional Chinese medicine composition has the advantages of definite curative effect, integral regulation and simultaneous treatment of mind and body, and can be popularized and applied on a large scale.

To provide a new male climacteric disorder-ameliorating composition using a safe material free from side effects, and to provide a medicine, food and drink containing the composition.SOLUTION: The male climacteric disorder-improving composition contains a treated product of an Agaricus fruit body.SELECTED DRAWING: Figure 13