90 results about "Erectile dysfunction" patented technology

The present invention relates to a compound exhibiting excellent agonist activity against melanocortin receptors. More specifically, the present invention relates to a compound of Formula 1, a pharmaceutical composition comprising the compound as an active ingredient, and a use thereof, and the compound of the present invention exhibits excellent agonist activity against melacortin-4 receptors and can be particularly useful in preventing or treating obesity, diabetes, inflammation and erectile dysfunction.

The invention relates to an extraction and culture method of urine-derived stem cells, and belongs to the field of cell biology and regenerative medicine. The method comprises the following steps: coating a culture plate with a gelatin solution; collecting clean midstream urine of healthy people and adding antibiotics; centrifugally separating the cell precipitate; washing with a phosphate buffer solution; re-suspending the precipitate by using a urine stem cell complete culture medium for primary culture; and after the cells grow to a certain fusion degree, carrying out passage amplification. The urine stem cell complete medium comprises a basic medium, fetal calf serum, epidermal growth factors, platelet-derived growth factors and basic fibroblast growth factors. By adopting the method disclosed by the invention, the urine-derived stem cells can be efficiently and stably separated from urine, and the obtained cells have high multiplication capacity, good stemness maintaining capacity, multidirectional differentiation potential and immunoregulation function, and can provide an ideal seed cell source for treating diseases such as diabetic erectile dysfunction.

The invention provides a novel pharmaceutical composition comprising sildenafil and cabergoline and method of use thereof for treating erectile dysfunction and / or male hypogonadism.

The invention relates to haptoglobin or a nucleic acid encoding haptoglobin for use in treating or preventing of exaggerated erectile response and / or preventing permanent erectile dysfunction. In addition, the invention relates a pharmaceutical composition for use in treating or preventing exaggerated erectile response and / or preventing permanent erectile dysfunction, wherein the pharmaceutical composition comprises an adeno-associated viral (AAV) vector with a transgene encoding a haptoglobin gene. The exaggerated erectile response may be priapism, for example priapism associated with sickle cell disease (SCD).

There is provided a composition for topical application to the penis for the treatment of erectile dysfunction, the composition being free of glyceryl trinitrate (GTN), sildenafil and an acetylcholinesterase inhibitor, and comprising volatile and non-volatile solvents, the volatile solvents comprising a lower alcohol and water and the non-volatile solvents comprising a polyhydric alcohol and a glycol. Preferably, the composition does not contain any pharmaceutically active ingredients for the treatment of erectile dysfunction. Also provided is a method of determining the cooling ability of a test composition, such as the composition described above.

An implantable system for treatment of climacturia has an inflatable penile implant and an inflatable cuff that is implantable around at least a portion of a urethra. A pump is operatively coupled to the penile implant and to the cuff to inflate the penile implant in treating erectile dysfunction and to inflate the cuff in treating climacturia.

This invention belongs to the field of traditional Chinese medicine, specifically relating to a topical delay spray and its preparation method. The invention uses the dried epidermis of the Huaxi toad (with the toad venom removed), and extracts it efficiently through a combination of water and alcohol extraction. Male silkworm moth oil can nourish and strengthen the body, tonify the liver and kidneys, and combat fatigue; studies have shown that male silkworm moth oil can effectively treat kidney yang deficiency. This invention combines the synergistic effects of toad skin extract and male silkworm moth oil to prepare a delay spray that can significantly treat premature ejaculation and erectile dysfunction in men. This preparation has the advantages of direct action, sustained release, avoidance of drug contact, and simple operation. This invention further improves the rational utilization system of toad resources, provides a practical solution for the efficient development of toad medicinal resources, and significantly reduces production and clinical application costs.

The invention relates to a crystal form of a compound shown as a formula I or a pharmaceutically acceptable salt thereof and a preparation method of the crystal form of the compound shown as the formula I or the pharmaceutically acceptable salt thereof. The compound of the formula I or the pharmaceutically acceptable salt thereof is used for treating cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, heart failure, pulmonary arterial hypertension (WHO levels I, II, III, IV), angina pectoris, thrombus, restenosis, myocardial infarction, stroke, cardiac insufficiency, fibrosis, pulmonary hyperplasia, erectile dysfunction, asthma, chronic kidney disease, diabetes, and the like. The composition can be used for treating liver cirrhosis, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome, acute lung injury, pulmonary fibrosis, cystic fibrosis or interstitial lung disease.

Microparticles that contain miRNA that controls the production of nitric oxide and are an agent for promoting the production of nitric oxide are new microparticles that enable controlling the expression of a protein and / or a gene related to erectile dysfunction; a preventive drug or a therapeutic drug for erectile dysfunction; a method for improving erectile dysfunction; it is preferable that the microparticles be exosomes; and it is preferable that the microparticles of the present invention contain miRNA targeting a gene concerning the expression of nitric oxide synthase as the miRNA that controls the production of nitric oxide, and be an agent for promoting the expression of nitric oxide synthase.

The invention provides application of lactobacillus reuteri to improvement of prostatitis and erectile dysfunction. The bacterial strain is lactobacillus reuteri NHNK-2001, the lactobacillus reuteri NHNK-2001 is preserved in the China Center for Type Culture Collection on April 25, 2024, and the preservation number of the lactobacillus reuteri NHNK-2001 is CCTCC (China Center for Type Culture Collection) NO: M 2024800. The NHNK-2001 has the functions of generating L-citrulline, repairing aged vascular endothelial cells, promoting vasodilation, repairing aged prostate cells and reducing prostatitis, and can be used for preparing products for improving prostatitis and erectile dysfunction.

The present invention relates to a crystalline form I represented by Formula 1, which may be characterized by XRD patterns, DSC profiles, and / or TGA profiles, a method for preparing the same, and a pharmaceutical composition comprising the same, useful for the treatment of prevention of obesity, diabetes, inflammation, or erectile dysfunction. (see formula 1) wherein R1 is C2-C5 alkyl.

A genetically modified mesenchymal stem cell including an exogenous nucleic acid including a Klotho encoding region operably linked to a promoter or promoter / enhancer combination, wherein the genetically modified mesenchymal stem cell exhibits increased Klotho expression compared to an unmodified mesenchymal stem cell. Also disclosed are methods of treating a patient including administering a therapeutically effective number of the genetically modified mesenchymal stem cells to the patient. The methods of treatment include treating the patient for a neurodegenerative disease; cancer; organ fibrosis; renal disease; age-related changes of organs or organ systems; to slow, reverse and / or inhibit aging; arteriosclerosis; dementia; diabetes mellitus; erectile dysfunction; autoimmune diseases or autoimmune-related diseases; an inflammatory disease of the lung and sepsis.

The invention relates to a traditional Chinese medicine composition for treating damp-heat downward flow type erectile dysfunction. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3-9 parts of radix gentianae, 1-3 parts of centipede, 5-10 parts of earthworm, 3-9 parts of fructus cnidii, 3-9 parts of radix et rhizoma rhei, 3-9 parts of radix angelicae sinensis, 3-9 parts of radix rehmanniae recen, 3-9 parts of bupleurum chinense, 6-15 parts of semen plantaginis, 3-9 parts of caulis clematidis armandii, 3-9 parts of rhizoma alismatis, 15-30 parts of poria cocos and 10-30 parts of herba epimedii. According to the pathogenesis characteristics of damp-heat downward flow type, especially erectile dysfunction caused by stasis obstruction caused by damp-heat accumulation in bladder and prostate, the radix gentianae liver purging decoction is adopted as a basic formula, and the traditional Chinese medicine is prepared through addition and subtraction. All the medicines are compatible, the effects of clearing damp-heat in lower jiao and soothing liver and vibrating yang are further enhanced compared with a basic formula, and the whole formula has the effects of clearing heat and promoting diuresis, promoting blood circulation to remove meridian obstruction and soothing liver and eliminating wilt together.

Disclosed in the present invention are a method and composition for improving reproductive health and related use thereof in preparing nutritional products, health-care products, foods, beverages, animal feeds, or drugs for improving reproductive health. The method and composition of the present invention can improve erectile dysfunction, increase testosterone level, ameliorate hypogonadism, and ameliorate decreased sexual desire.

The invention discloses a preparation method of an epimedium extract and the epimedium extract and application thereof. The preparation method comprises the following steps: ultrasonically extracting epimedium in a solvent, collecting an organic phase and an aqueous phase after the extraction, and drying the organic phase after decompression concentration to obtain an epimedium extract A; adding water-saturated n-butanol to the aqueous phase for extraction, collecting the n-butanol phase after the extraction, and drying the n-butanol phase epimedium extract B; enzymolyzing the extract A to obtain an epimedium enzymolysate; acid-hydrolyzing the extract B to obtain an epimedium acid hydrolysate; and uniformly mixing the enzymolysis product and the acid hydrolysate to obtain an epimedium extract C. The extract A prepared by the invention mainly contains icariin, and the extract B mainly contains epimedin C; the yield of icariin II in the enzymatic hydrolysate is 40.19-86.25%, and the yield of dehydrated icariin in the acid hydrolysate is 61.27-77.51%. The epimedium extract C has obvious anti-fatigue and erectile dysfunction treatment effects.

To provide a new male climacteric disorder-ameliorating composition using a safe material free from side effects, and to provide a medicine, food and drink containing the composition.SOLUTION: The male climacteric disorder-improving composition contains a treated product of an Agaricus fruit body.SELECTED DRAWING: Figure 13

The massage device using the fabric that is the article of the design is a massage device used in response to social needs, such as the need to treat erectile dysfunction through precise stimulation, alleviate insomnia and lower back pain, and prevent suicide through the euphoria caused by precise stimulation of the groin. This massage device is constructed by sewing together an outer fabric and an inner fabric with cushion holders, offset from each other to the left and right. The article has a pair of slits cut above and below the cushion holder in the outer fabric, and a pair of slits cut above and below the cushion holder in the inner fabric from the opposite direction to the outer fabric, allowing the cushion holder to be folded back between the pair of slits in the outer and inner fabrics. When the two cushion holders are folded back, an insertion opening is formed in the center. When used by a man, the penis is inserted into the insertion opening, the folded cushion is placed in close contact with the groin, and pressure is applied to the folded cushion, allowing for a groin massage.

There is provided a composition for topical application to the penis for the treatment of erectile dysfunction, the composition being free of glyceryl trinitrate (GTN), sildenafil and an acetylcholinesterase inhibitor, and comprising volatile and non-volatile solvents, the volatile solvents comprising a lower alcohol and water and the non-volatile solvents comprising a polyhydric alcohol and a glycol. Preferably, the composition does not contain any pharmaceutically active ingredients for the treatment of erectile dysfunction. Also provided is a method of determining the cooling ability of a test composition, such as the composition described above.

The invention provides a traditional Chinese medicine composition for treating type 2 diabetic erectile dysfunction and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The composition is prepared from radix bupleuri, radix paeoniae alba, radix rehmanniae preparata, Chinese yam, fructus corni, cortex moutan, poria cocos, rhizoma alismatis, herba cistanche, centipede, flos carthami, cortex eucommiae, radix angelicae sinensis and liquorice root. Clinical research proves that the total treatment effective rate of the traditional Chinese medicine composition reaches 78.13% which is obviously superior to 28.13% of a control group, the IIEF-5 score can be obviously improved, the traditional Chinese medicine symptoms can be improved, the effect on the aspects of improving sexual confidence and sexual nature indexes, reducing time worry and other psychological indexes is outstanding, and meanwhile the adverse drug reaction occurrence rate is not obviously different from that of the control group. The traditional Chinese medicine composition has the advantages of definite curative effect, integral regulation and simultaneous treatment of mind and body, and can be popularized and applied on a large scale.

To provide a new male climacteric disorder-ameliorating composition using a safe material free from side effects, and to provide a medicine, food and drink containing the composition.SOLUTION: The male climacteric disorder-improving composition contains a treated product of an Agaricus fruit body.SELECTED DRAWING: Figure 13

Provided is a method for treating disorders or conditions related to erectile dysfunction. The method includes administering to a subject in need thereof a therapeutically effective amount of mesenchymal stem cells or secretome thereof, wherein the mesenchymal stem cells or secretome are derived from human amniotic fluid.

The invention further relates to compounds, pharmaceutical compositions and methods for treating a subject for sexual function, such as sexual disorder or sexual dysfunction (SD), for inducing subject weight loss, for effectuating weight maintenance by a subject, whether or not the weight maintenance is used alone or in combination with a subject's weight loss, and / or for improving a subject's subjective state of well-being, self-esteem and / or self-confidence. Examples of SD contemplated by the present invention include but are not limited to female sexual disorder (FSD), female sexual arousal disorder (FSAD), female sexual interest / arousal disorder (FSIAD), female hypoactive sexual desire disorder (HSDD), female orgasmic disorder (FOD), female sexual pain disorder (FSPD), sexual interest arousal disorder (SIAD), male sexual disorder (MSD), male hypoactive sexual desire disorder (MSHDD), erectile dysfunction (ED), Pyronine's disease (PD), male premature ejaculation (MPE), male delayed ejaculation (MDE), male decreased libido (MDL), male dry orgasm (MDO).

An improved condom-style vacuum therapy device has a region of the sheath formed of an air-permeable material that is covered by an air-impermeable barrier so as to define a lumen therebetween. A conduit defining an airflow pathway is located in fluid communication with the lumen, and is connected to a vacuum source in order to draw air out of the interior of the condom-style device through the air-permeable region. When the condom-style device is worn over the penis, a sealing element proximate to the open end serves to at least partially restrict the intrusion of ambient air into the condom. As a result, the air pressure within the sheath of the condom is reduced to below ambient air pressure, serving to prevent or treat actual or potential erectile disfunction and / or to enhance sexual performance, while also providing the prophylactic and / or contraceptive benefits associated with condom use.

A marker for characterizing an EPC subpopulation, an EPC subpopulation, and a use thereof. Indicators for distinguishing EPC subpopulations comprise CD144, vWF, CD133, or phagocytic capacity. On the basis of these indicators, identification, sorting, separation, or enrichment of EPC subpopulations can be achieved. Also provided are a use of late EPC in the preparation of a drug for treating stroke, erectile dysfunction, and ischemic diseases, and a method for treating stroke, erectile dysfunction, and ischemic diseases.

The present invention relates to haptoglobin or a nucleic acid encoding haptoglobin for use in the treatment or prevention of an excessive erectile response and / or the prevention of permanent erectile dysfunction. Furthermore, the present invention relates to a pharmaceutical composition for use in the treatment or prevention of an excessive erectile response and / or the prevention of permanent erectile dysfunction, the pharmaceutical composition comprising an adeno-associated virus (AAV) vector carrying a transgene encoding a haptoglobin gene. The excessive erectile response may be, for example, priapism associated with sickle cell disease (SCD).

The present invention discloses a composition, a preparation and a preparation method and application thereof for treating benign prostatic hyperplasia, relating to the technical field of traditional Chinese medicine. The composition comprises the following components: Flemingia philippinensis Merr. ex Rolfe, Curcuma zedoaria (Christm.) Rosc., Eucommia ulmoides Oliv., Achyranthes bidentata Blume, Codonopsis pilosula (Franch.) Nannf., Astragalus membranaceus (Fisch.) Bunge, Cinnamomum cassia Presl, Curculigo orchioides Gaertn., Epimedium brevicornu Maxim., Phellodendron amurense Rupr., Poria cocos (Schw.) Wolf, Paeonia suffruticosa Andr., Paeonia lactiflora Pall. and Prunus persica (L.) Batsch. The preparation is prepared from the composition as a traditional Chinese medicine raw material medicine, and the preparation method comprises: mixing the raw material medicines, soaking in water, decocting and taking the medicinal liquid, and further processing the obtained medicinal liquid into a common traditional Chinese medicine preparation according to a conventional process. In the treatment process of benign prostatic hyperplasia with the traditional Chinese medicine composition and the preparation thereof, patients rarely have situations such as orthostatic hypotension and erectile dysfunction, and are superior to the treatment with pure western medicine in relieving the prostate symptoms of patients, improving the quality of life and improving the lower urinary tract symptoms, and moreover, the effects of relieving the symptoms of soreness and weakness of the waist and knees, fatigue and weakness, and aversion to cold and cold limbs are obvious.

The invention discloses a ginseng, herba cistanche and rhizoma polygonati composition capable of improving erectile dysfunction caused by aging and a preparation method, and belongs to the field of food processing. The preparation method comprises the following steps: (1) taking processed product raw materials, adjusting the moisture content of the processed product raw materials to 60-80%, and then sealing the processed product raw materials; (2) carrying out heat preservation on the sealed raw materials; (3) taking out the raw materials subjected to heat preservation, and drying until the moisture content of the raw materials is reduced to 15-40%; (4) sealing the raw materials treated in the step (3), and carrying out heat preservation; and (5) taking out the raw materials treated in the step (4), and drying to obtain the processed product. The contents of glucose and maltose in the raw materials are improved by pretreating the raw materials of ginseng, cistanche and rhizoma polygonati, and the functional food ingredient in which the sum of the content of AFG and the content of FuArg is 2.5%-8% and the mass ratio of AFG to FuArg is 5: 1-1: 3 is finally prepared through the processes of moisture regulation, sealing, heat preservation and the like. The traditional Chinese medicine composition has an obvious effect of improving erectile dysfunction caused by aging.

This invention relates to a restraint-free wearable intelligent sensing device and method for patients with erectile dysfunction (ED), belonging to the field of medical monitoring equipment and technology. The device includes an underwear-like main structure, a data acquisition unit, a micro-control module, a power supply module, and an electrical stimulation module. The underwear-like main structure has a data acquisition and monitoring area composed of multiple annular fiber sensing units arranged in a columnar elephant trunk structure. Each annular fiber sensing unit has an independent pressure-sensitive fiber sensing module. The data acquisition unit collects the wearer's pressure and temperature data in real time. The micro-control module is connected to the data acquisition unit to process and transmit the data collected. The method employs a multi-sensor signal processing stage algorithm and a cloud-based monitoring and closed-loop control stage algorithm. Based on the acquired loop-level monitoring data, it provides real-time feedback and prompts for adjustments, improving treatment convenience and personalization, and providing a more comprehensive, precise, and restraint-free solution for ED monitoring.

The penis phototherapy device can surround a body part, such as a penis, to provide light therapy to all sides. The primary elements of the penis phototherapy device include: a flexible base material; a light emitting array affixed to a flexible circuit board; a clear and flexible array cover material; a controller with electronics and a power source; elements to removably affix the flexible base material to itself to cause the device to surround a body part, and slots that allow a user to wear the penis phototherapy device attached to a belt. When used to treat a penis, the light improves sexual ability and health and reduces symptoms of erectile dysfunction.