307 results about "Ginsenoside" patented technology

The invention belongs to the technical field of medicinal and edible Chinese herbal medicine alcoholic drink, and particularly relates to lactobacillus plantarum and application thereof in fermentation of ginsenoside. The lactobacillus plantarum is specifically lactobacillus plantarum L100, and the preservation number of the lactobacillus plantarum L100 is CGMCC (China General Microbiological Culture Collection Center) No. 34425. The lactobacillus plantarum L100 has the function of converting and preparing the rare ginsenoside, basic components of ginseng can be directionally converted into high-value rare ginsenoside (such as Rg3, Rg5 and Rh1), and particularly, the lactobacillus plantarum L100 has extremely high specificity on generation of F5 and Rh10. Ginseng fermentation liquor obtained by fermenting ginseng through lactobacillus plantarum L100 and extracting solutions of medicinal and edible components such as codonopsis pilosula, astragalus membranaceus, liquorice and cistanche deserticola are used for preparing the liqueur, and a liqueur product with potential effects in the aspects of oxidation resistance, inflammation resistance, immunoregulation and the like is obtained.

The invention relates to the technical field of cosmetics, and discloses an anti-inflammatory soothing cosmetic composition which comprises the following components in percentage by weight: 0.5%-4% of a barrier repairing component, 0.5%-3% of an immunoregulation component, 0.3%-2.5% of a nerve soothing component, 0.3%-3% of an anti-inflammatory plant compound, 1%-10% of a moisturizing soothing enhancer and the balance of auxiliary materials. According to the components, through a five-dimensional synergistic mechanism of barrier repair, immune tolerance, nerve desensitization, anti-inflammatory itching relieving, moisturizing and stability maintaining, anti-inflammatory relieving and barrier repair are remarkably enhanced; ceramide, rare ginsenoside, phytosterol ester and free fatty acid are introduced to synergistically construct a bionic liposome which is closer to the composition of human cuticle lipid, so that the transdermal absorption and stability are enhanced, and the repair efficiency is remarkably improved; the dipotassium glycyrrhizinate, the tamarix chinensis flower extract, the purslane extract, the dinoflaxanthine and the baicalin cooperate to quickly resist inflammation and relieve itching and strengthen barrier repair, so that the composition is suitable for highly sensitive skin.

The invention belongs to the technical field of medicine and health care, and particularly relates to a preparation method of an American ginseng root water extract rich in rare ginsenoside and application of the American ginseng root water extract in improving the immune and anti-tumor direction. The preparation method comprises the following steps: step 1, carrying out superfine grinding on American ginseng, and sieving; step 2, adding the American ginseng powder into water, and then adding compound enzyme for enzymolysis to obtain enzymatic hydrolysate; s3, after the enzymolysis is finished, heating the enzymatic hydrolysate, extracting twice, and mixing after the extraction is finished; and S4, inoculating compound lactic acid bacteria into the mixed solution, fermenting to obtain a fermentation solution, blending, and sterilizing to obtain the American ginseng afterbiogen beverage. According to the invention, a new physical-biological combined process is adopted, and crushing, enzymolysis, extraction, fermentation and blending are carried out, so that the American ginseng metagen beverage rich in rare ginsenoside is obtained, and the rare ginsenoside has a remarkable anti-tumor effect and higher activity.

The invention belongs to the technical field of biological agents, and particularly relates to ginsenoside variant flavobacterium DG-16 and application thereof in relieving continuous cropping obstacles of angelica sinensis and improving the quality of the angelica sinensis. According to the ginsenoside variant flavobacterium DG-16 disclosed by the invention, the growth of angelica sinensis is promoted by increasing the contents of jasmonic acid and cytokinin hormones, reducing the contents of gibberellin and salicylic acid hormones and promoting the circulation and utilization of nitrogen; in addition, the flavobacterium ginsenoside variant DG-16 can significantly increase the chlorophyll content, is beneficial to photosynthesis of the angelica sinensis, effectively changes the physiological and biochemical states of the angelica sinensis, can resist root rot of the angelica sinensis so as to relieve successive cropping obstacles and improve the quality, and has a significant effect.

The invention discloses a method for extracting ginsenoside based on a supercritical extraction method, and relates to the technical field of traditional Chinese medicine extraction. The ginsenoside is extracted through a supercritical extraction method, the extraction process is convenient and efficient, the purity of the ginsenoside is high, organic solvent residues are avoided, the method is green and environmentally friendly, carbon dioxide can be recycled, and the operation cost is low; through degreasing pretreatment, fat-soluble components in ginseng powder are removed, the extraction purity of saponin is increased, the solid loading capacity of supercritical extraction is reduced, the mass transfer resistance is reduced, and the extraction efficiency is improved; the ginsenoside is purified in a post-treatment mode of resin adsorption and elution, polar impurities can be further removed, glutamine is adopted for surface functionalization of the resin, acylamino and carboxyl are introduced to the surface of the resin and can form hydrogen bonds with phenolic hydroxyl groups in the ginsenoside, functional adsorption is achieved, meanwhile, impurities are removed, and the content of the ginsenoside is increased. Reaction conditions are simple and mild, and adsorption efficiency is high.

The invention discloses radix notoginseng stem and leaf rare ginsenoside as well as a preparation method and application thereof, and belongs to the technical field of ginsenoside. The radix notoginseng stem and leaf rare ginsenoside comprises Rk3, Rh4, S-Rg3, R-Rg3, Rk1 and Rg5. The radix notoginseng stem and leaf rare ginsenoside can be used for preparing radix notoginseng stem and leaf rare ginsenoside. The preparation method comprises the following steps: mixing the pseudo-ginseng stem and leaf extract with an acetic acid aqueous solution, reacting at 105-120 DEG C for 10-40 minutes, and drying; in the preparation process, macroporous resin purification is not carried out. According to the scheme, part of chemical substances in the panax notoginseng stem and leaf extract can be rapidly converted at a low temperature, new active substances Rh4, S-Rg3, R-Rg3, Rk1 and Rg5 with high purity are obtained at the same time, and the obtained panax notoginseng stem and leaf rare ginsenoside can effectively inhibit propionibacterium acnes, burkholderia cepacia and malassezia furfur.

The invention provides a method for preparing rare ginsenoside through conversion of kombucha, the rare ginsenoside and application, and belongs to the technical field of biological medicine. A symbiotic system is formed by multiple bacteria such as acetic acid bacteria, gluconacetobacter, foal bacillus and the like and fungi, after the symbiotic system is domesticated, the American ginseng stem and leaf extract is fermented through multi-bacteria synergistic catalysis, the rare ginsenoside can be efficiently prepared, the highest conversion rate of Rb3 and Rd can reach about 90%, and the yield of Rb3 and Rd can reach about 90%. Meanwhile, the contents of rare ginsenosides Rg3 (20S), Rg5, Rh2 (20R) and Rh2 (20S) are remarkably increased and are increased by about 15 times at most, and efficient conversion of various ginsenosides is achieved.

The invention discloses application of ginsenoside Rg5 in preparation of a medicine for treating Alzheimer's disease and an evaluation method, and relates to application of ginsenoside Rg5 in preparation of a medicine for treating Alzheimer's disease. The medicine improves A beta deposition, tau protein phosphorylation and neuron damage by adjusting the intestinal flora structure and metabolite level, and is used for relieving the pathological process of the Alzheimer's disease. The invention has the characteristics of multi-target effect, nerve protection, inflammation resistance and oxidation resistance.

The invention provides a probiotic composition for improving immunity and a preparation method thereof, and belongs to the technical field of probiotics. The preparation method comprises the following steps: fermenting selenium-enriched nostoc sphaeroides through selenium-enriched saccharomycetes to extract selenium-enriched nostoc sphaeroides polysaccharide and selenium-enriched nostoc sphaeroides protein peptide, mixing with traditional Chinese medicine polysaccharide obtained by extracting astragalus membranaceus, rhodiola rosea, codonopsis pilosula and pseudo-ginseng, and reacting with ferric salt to prepare a polysaccharide-Fe / selenium compound; solid residues are mixed and fermented, and active protein peptide is prepared from the solid residues and selenium-rich nostoc sphaeroides protein peptide; the probiotic composition capable of improving immunity is prepared by extracting a polysaccharide-Fe / selenium compound and a polysaccharide-Fe / selenium compound through an organic solvent, extracting a permeate through an organic solvent to obtain an active component, collecting a bacterial liquid, mixing and embedding the bacterial liquid in the polysaccharide-Fe / selenium compound and sodium alginate, and uniformly mixing the bacterial liquid with the active protein peptide, the active component, taurine and ginsenoside Rg3, so that the probiotic composition capable of improving immunity can play good anti-inflammatory, anti-oxidation, immunoregulation, anti-tumor, anti-virus and other roles, and has a good application prospect. Wide application prospects are realized.

The invention discloses a composite plant polypeptide composition with the effects of repairing pancreas and reducing blood sugar. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 50 parts of ginsenoside, 5 to 30 parts of radix astragali seu hedysari extract, 3 to 20 parts of radix rehmanniae polysaccharide, 2 to 15 parts of radix trichosanthis alkaloid, 5 to 25 parts of rhizoma dioscoreae polysaccharide, 5 to 30 parts of bitter gourd polypeptide, 3 to 20 parts of folium mori alkaloid, 8 to 40 parts of rhizoma polygonati polysaccharide, 5 to 25 parts of fructus hippophae flavone, 10 to 35 parts of wheat germ peptide, 2 to 15 parts of coptis berberine, 10 to 45 parts of corn stigma polysaccharide and 3 to 20 parts of saussurea involucrata polyphenol. 1-10 parts of sophora flavescens total alkaloids, 5-25 parts of a dendrobium extract, 5-30 parts of a radix puerariae extract, 8-35 parts of L-arabinose and 10-40 parts of small molecule peptides; 20 to 100 parts of collagen peptide and 15 to 80 parts of albumin peptide; 5-50 parts of microcrystalline cellulose, 3-30 parts of fructo-oligosaccharide and 0.5-5 parts of magnesium stearate; the limitation of single sugar control or simple component mixing in the prior art is broken through, a synergistic system of plant active components and functional polypeptides is constructed, and the purity and retention rate of the plant active components are improved by optimizing the extraction process.

The invention belongs to the technical field of pharmaceutical preparations. The invention discloses a multifunctional bionic nano preparation, a preparation method and application. According to the multifunctional bionic nano preparation, the ginsenoside Rg3 has the dual functions of a medicine and a membrane stabilizer, the platelet membrane has the natural targeting capability on circulating tumor cells and metastases, and meanwhile, the cationic liposome is used for adsorbing negatively-charged NETs nucleic acid protein compounds, so that potential reversal and active targeting are achieved, and the multifunctional bionic nano preparation has a good application prospect. And by co-carrying paclitaxel (PTX) and a photothermal agent (PCP) and integrating photothermal-chemotherapy-immunogenic death (ICD) induction functions, the tumor-related fibroblast activation can be effectively inhibited, circulating tumor cells can be efficiently captured, a tumor immune microenvironment can be remodeled, the tumor cells can be effectively killed, and tumor distal metastasis can be inhibited.

The invention provides a fingerprint spectrum and multi-component content determination method of a calamus-far nerve calming mixture, and relates to the field of quality control of traditional Chinese medicines. 31 common peaks are calibrated by establishing a fingerprint spectrum, and 24 common peaks can clearly belong to polygala tenuifolia. Meanwhile, synchronous content determination of seven components including chlorogenic acid, caffeic acid, ferulic acid, liquiritin, 2, 3, 5, 4 '-tetrahydroxy stilbene-2-O-beta-D-glucoside, 3, 6'-dimustard acyl sucrose and rosmarinic acid is realized. The method is good in precision, high in repeatability and stable and reliable in result, the medicine quality can be comprehensively and accurately reflected and controlled, and powerful support is provided for guaranteeing the safety and effectiveness of the calamus-far Ningmind mixture.

The invention provides a rare ginsenoside high-internal-phase Pickering emulsion microcapsule, a preparation method thereof and application of the rare ginsenoside high-internal-phase Pickering emulsion microcapsule in the aspects of uric acid reduction and kidney protection, and the preparation method comprises the following steps: (1) mixing a pectin aqueous solution and a tannic acid aqueous solution, adjusting the pH value, and stirring to obtain pectin-tannic acid composite sol, namely a water phase; (2) adding rare ginsenoside into the oil, and stirring to fully dissolve the rare ginsenoside to obtain an oil phase; (3) mixing the water phase and the oil phase, stirring, standing and carrying out ultrasonic treatment to obtain a crude emulsion; (4) emulsifying and homogenizing the crude emulsion to obtain crude emulsion; (5) carrying out high-pressure homogenization on the crude emulsion, so as to obtain a rare ginsenoside high-internal-phase Pickering emulsion; and (6) drying the rare ginsenoside high internal phase Pickering emulsion, so as to obtain the rare ginsenoside high internal phase Pickering emulsion microcapsule. The invention solves the problems of low safety, poor stability and low bioavailability of the traditional nano-emulsion, and belongs to the technical field of functional foods.

The invention discloses a coffee-flavor plant extract and a preparation method thereof, and the coffee-flavor plant extract is refined by using lophatherum gracile, Chinese olive, folium cortex eucommiae, dendrobium officinale, astragalus membranaceus, codonopsis pilosula, dandelion and liquorice as composite plant raw materials through multi-strain synergistic fermentation and oak barrel aging and curing technologies. The dissolution rate and bioavailability of various bioactive components such as chlorogenic acid, ginsenoside, curcumin and dendrobium polysaccharides are effectively improved through multi-strain synergistic fermentation. The oak barrel ageing endows the product with unique baking, nut and vanilla flavors, the taste is mellow, and the flavor characteristic of coffee is effectively simulated. The plant extract prepared by the invention is rich in various functional components, and can assist in improving the memory ability. Meanwhile, a healthy, caffeine-free and rich-flavor herbaceous plant beverage is provided for consumers, a new solution is provided for product development of plant extracts, and huge market potential and economic value are achieved.

The invention discloses a plant cell extract-containing traditional Chinese medicine aromatic penetration enhancer and a preparation method thereof, and the penetration enhancer comprises the following components in parts by mass: 8-15 parts of storax nano-vesicles, 3-8 parts of agilawood nano-vesicles, 1-5 parts of refined turpentine, 0.5-3 parts of panax notoginseng saponins, 0.5-3 parts of rhododendron dauricum oil and 20-35 parts of grape seed oil, the storax nano-vesicles and the agilawood nano-vesicles are exosome-like nano-vesicles extracted from plant secretion, and the particle size of the vesicles is 50-200 nm. Skin interstices are opened, skin meridians and blood are dredged, and accordingly relieving, inflammation resisting, redness improving and skin barrier repairing are achieved.

The invention belongs to the field of food engineering and traditional Chinese medicine functional foods, and discloses a preparation method of a tremella and ginseng composite freeze-dried product, which comprises the following steps: S1, preparing a decoction, weighing poria cocos, Chinese yam and other medicinal materials and ginseng slices according to a ratio, soaking, taking out the ginseng slices for later use, decocting the remaining medicinal materials, and filtering to obtain the decoction; s2, preparing a radix ophiopogonis zymolyte, namely crushing radix ophiopogonis, dissolving, adding a compound enzyme (cellulase: pectinase = 2: 1) for enzymolysis, and performing enzyme deactivation and concentration to obtain the zymolyte; s3, the tremella is boiled to produce glue, the soaked tremella and the medicine soup are mixed and boiled, and the radix ophiopogonis zymolyte, the ginseng powder and the sweetening agent are added; s4, molding and filling into a mold: filling the white fungus thick soup into the mold, and embedding the soaked ginseng slices, Chinese wolfberry fruits and red date slices; and S5, freeze-drying and packaging, namely sealing after pre-freezing and sublimation drying. According to the preparation method, the rehydration time of the product is less than or equal to 67 seconds, the retention rate of ginsenoside is greater than or equal to 90% and the distribution of ingredients is uniform and visual through segmented ginseng treatment (slice embedding and powder supplementing), radix ophiopogonis enzymolysis and process parameter standardization, so that the preparation method is suitable for industrial production of health-care foods and ready-to-eat foods.

The application discloses application of 12-ketolithocholic acid in preparation of a medicine for preventing or treating atopic dermatitis, and the 12-ketolithocholic acid can inhibit NUAK2 kinase activity expression and activity, and then negatively regulates a downstream TNF inflammatory signal path, significantly down-regulates IL-1beta, IL-8 and various proinflammatory factor secretion, and inhibits keratinocyte excessive inflammatory activation. The 12-ketolithocholic acid and ginsenoside F2 are compounded and used in combination to produce synergistic effect, and the anti-inflammatory effect is further enhanced; the active substance has low cytotoxicity and good safety, can be prepared into an external ointment or an oral preparation, and has a wide application prospect in the field of atopic dermatitis prevention and treatment.

According to the ginseng extraction system and method provided by the invention, the dual goals of high purity and high yield of ginsenoside extraction are achieved through raw material adaptive parameter pre-optimization, self-adaptive cascade purification and activity protection, the enrichment effect of high-value monomer saponin is remarkable, and the loss of active ingredients is accurately controlled. According to the application, a detection-decision-regulation full-process closed-loop intelligent control system is constructed, near infrared spectrum rapid screening and HPLC-MS / MS accurate quantitative dual-mode online detection are fused, real-time and accurate monitoring of the saponin content is realized, and off-line detection and artificial experience parameters are not needed; the multi-target central control unit can automatically decide a purification path and process parameters according to detection data, and designs such as membrane pollution on-line monitoring, automatic backwashing and solvent circulating preheating are combined, so that continuous operation of the process is ensured, and production interruption caused by equipment failure and process fluctuation is avoided.

The invention discloses essence lotion with repairing and anti-wrinkle functions. The essence lotion is prepared from the following components in parts by weight: 0.1 to 1.0 part of rare ginsenoside, 0.1 to 1.5 parts of panax notoginseng leaf / stem extract, 3 to 20 parts of emollient, 8 to 20 parts of polyhydric alcohol humectant, 0.2 to 10 parts of saccharide humectant, 0.1 to 5 parts of emulsifier, 0.1 to 0.8 part of thickener, 0.1 to 5 parts of skin conditioner, 0.01 to 0.2 part of chelating agent and the balance of water. The essence lotion provided by the invention has the effect of widely protecting the skin, achieves a synergistic effect by adding the specific rare ginsenoside and the panax notoginseng leaf / stem extract, and is remarkable in effect. Safety inspection, human body efficacy evaluation and consumer use test results prove that after the traditional Chinese medicine composition is used, the obvious soothing, repairing and anti-wrinkle effects on facial skin are achieved, and no side effect or adverse reaction exists.

The application provides a sheep fattening complete granular feed and a preparation method and a feeding method thereof, relates to the technical field of feed, and the sheep fattening complete granular feed comprises the following components: ginseng stem and leaf, red yeast extract and sheep group basic feeding daily ration. The application solves the technical problems of high total ginsenoside extraction cost, low single stomach animal utilization rate, slow growth during the sheep fattening period and frequent outbreaks of diseases, achieves the technical effects of improving ginsenoside utilization efficiency, synergistically improving sheep immunity and improving the average daily weight gain of sheep during the whole period, and meanwhile, the process is simple, and the cost is low.

The utility model discloses a ginsenoside extracting and filtering device which comprises a box body, and a flushing mechanism is arranged at the top of the box body; a filtering mechanism is arranged in the box body, a liquid outlet is formed in the bottom of the box body, a liquid inlet is formed in the top of the box body, and sealing rings are arranged on the two sides of the box body. The filter mechanism is provided with a filter screen I and a filter screen II. By means of the multi-stage telescopic rod, the blocked filter screen can be pushed out of the box body to be cleaned, meanwhile, the other filter screen can be rapidly put into filtering work, and shutdown is not needed. By means of the design, the filtering efficiency is greatly improved, and the spray heads arranged on the flushing mechanism are installed on the branch pipes in an inclined mode by 15-45 degrees. By means of the design, the nozzle can wash the filter screen in an all-dimensional and multi-angle mode, it is guaranteed that impurities on the filter screen are thoroughly removed, the filtering performance of the filter screen is recovered, and then it is guaranteed that the quality of an extracting solution is stable.

The invention discloses a method for preparing the ginsenoside preparation by biological engineering technology, wherein the ginsenoside preparation comprises at least one of the saponin-enriched preparation and the saponin-enriched syrup; the compound bio-enzyme preparation prepared by the combined bacteria preparation of yeast and lactic acid bacteria provided by the invention is rich in amino acid residues, amides, coenzymes and active groups such as lactic acid and linoleic acid; and the ginsenoside preparations containing ginsenosides can be prepared by adding monosaccharides or polysaccharides to the compound bio-enzyme preparations, providing new directions and ideas for obtaining ginsenosides and their products.

This invention relates to the field of biomedical technology, specifically to a heart-spleen synergistic regulatory composition based on Chinese yam complex peptides, its preparation method, and its application in improving heart-spleen dysfunction. The method involves first gelatinizing Chinese yam, then sequentially performing primary endopeptidation with papain and secondary fine exopeptidation with flavor protease, followed by separation via a 1000 Da ultrafiltration membrane to directionally prepare a Chinese yam complex peptide with a peptide fraction of at least 90% having a molecular weight less than 1000 Da. This complex peptide is then combined with extracts of ginseng, lotus seed, longan pulp, and tangerine peel in a specific ratio. The yam peptides obtained by this invention can self-assemble with macromolecular hydrophobic components such as ginsenosides in the system to form microscopic peptide-saponin complexes, acting as biological delivery carriers and significantly improving the transmembrane absorption rate of macromolecular active ingredients in individuals with weak spleen and stomach. Simultaneously, the two-step enzymatic hydrolysis process achieves the simultaneous retention of highly active small molecules and precise debittering.

The invention provides a beta-glucosidase mutant from Paenibacillus phyllosphaerae, and a method for efficiently preparing rare ginsenoside F2 by using an enzyme method and a whole-cell method, and particularly provides a beta-glucosidase mutant from Paenibacillus phyllosphaerae and a method for efficiently preparing rare ginsenoside F2 by using a beta-glucosidase mutant from Paenibacillus phyllosphaerae. The method comprises the following steps: engineering-modifying beta-glucosidase by utilizing computer-aided design, constructing a mutant library, carrying out primary screening and secondary screening to obtain two high-activity mutants Q7D and G189A, constructing a combined mutant Q7D / G189A, transforming the combined mutant Q7D / G189A into genetically engineered bacterium escherichia coli for expression, and producing F2 by utilizing a whole-cell method. Finally, the highest yield of 18.01 g / L is achieved after the reaction is carried out for 10 h in a 5 L fermentation tank and is 6.82 times that of a shake flask, and the purity of F2 reaches up to 82.20% after the reaction is carried out for 24 h finally. The invention not only provides an efficient solution for large-scale production of rare saponin F2, but also provides a transferable framework for designing and engineering diversified glycoside hydrolase in customized biological catalysis.

The present application relates to a kind of composition capable of relieving fatigue-related emotional fluctuation and anxiety and its application.The composition includes: and magnolol, ergothioneine, ginsenoside and plant extract;The plant source of the plant extract includes eucommia leaf and schisandra chinensis.The above components cooperate with each other, and have significant synergistic effect in relieving tension, anxious mood and anti-depression.

The application discloses a method for separating and purifying ginsenoside F2 from fermentation liquor, and belongs to the technical field of separation and purification. The method comprises the following steps: taking the fermentation liquor from a tank, centrifuging, taking the lower precipitate, adding ethanol to stir and extract, filtering after extraction, and spin-drying the filtrate to obtain a crude product; then dissolving the crude product in an ethanol aqueous solution with a volume fraction of 10-40% to form a sample solution; then performing sample loading on YLT810 resin, and after sample loading is completed, washing impurities with an ethanol aqueous solution with a volume fraction of 45-50%, and when the liquid-phase purity of the target product reaches 70-75%, eluting with an ethanol aqueous solution with a volume fraction of 60-65%, collecting the eluate, and spin-drying to collect the solid, so that ginsenoside F2 is obtained. The method can obtain ginsenoside F2 with a purity of more than 85%, and the yield can reach more than 80%, and is suitable for industrial production.

The application provides a combined drug, a liposome, a biomimetic liposome, a preparation method of the combined drug, the liposome and the biomimetic liposome, and application of the combined drug, the liposome and the biomimetic liposome in preparation of an anti-breast cancer lung metastasis drug, and belongs to the technical field of biological medicines. The combined drug comprises panatinib and ginsenoside Rg3. The application further provides a liposome PNT-Rg3-Lipo for simultaneously loading the two, and a biomimetic liposome MM / PNT-Rg3-Lipo coated with a macrophage membrane. Experiments show that the combination of the two can synergistically regulate chemokines CXCL1 , CXCL2 and CXCL11 , and the effect is better than the sum of the single use. The MM / PNT-Rg3-Lipo has uniform particle size, retains integrin alpha 4 / beta 1 functional proteins, can target lung metastases, significantly reduces metastatic nodules, and has good biocompatibility. The application provides an effective new strategy for resisting breast cancer lung metastasis.

This invention relates to the field of health food and pharmaceutical preparation technology, specifically to a method for preparing ginsenoside freeze-dried flash-release tablets. These ginsenoside freeze-dried flash-release tablets are made from the following raw materials in the indicated weight ratios: 3-5 parts ginseng extract, 8-12 parts matrix support agent, 1.5-2.5 parts binder, and 0.3-0.5 parts prebiotics. The method includes the following steps: S1, ingredient dissolution; S2, high-speed emulsification; S3, vacuum degassing; S4, quantitative filling; S5, ultra-low temperature quick-freezing; S6, programmed freeze-drying; and S7, aluminum-aluminum sealed packaging. This invention has the advantages of convenient administration, rapid absorption, pure formulation, good stability, and excellent taste.

The application discloses a strain of yeast for efficiently transforming ginsenosides and polysaccharides and application thereof, and belongs to the technical field of functional component transformation. According to the total ginsenoside and polysaccharide content in ginseng, a strain of yeast for efficiently transforming ginsenosides and polysaccharides is screened by taking a comprehensive score as an index, and is identified as Zygosaccharomyces bisporus by morphology, physiology and biochemistry and molecular biology, and is preserved in the China Center for Type Culture Collection with a preservation number of CCTCC NO: M 2020912. After transformation, the total ginsenoside content in American ginseng and ginseng is respectively increased by 67.81% and 107.03%, and the polysaccharide content is respectively increased by 238.61% and 205.87%. The DPPH antioxidant capacity, ABTS antioxidant capacity, blood sugar lowering capacity and blood lipid lowering capacity of the total ginsenoside extract and polysaccharide extract of the American ginseng and ginseng after transformation are all improved. The yeast screened by the application has a wide application prospect.

The invention provides a bacillus proteolyticus Sys-Gs-006 strain for producing ginsenoside Rh1, the strain is preserved in China Center for Type Culture Collection, the preservation date is December 9, 2025, and the preservation number is CCTCC NO: M20252815; the 16S rDNA (ribosomal deoxyribonucleic acid) sequence of the strain is as shown in SEQ ID NO. 1. The bacillus proteolyticus Sys-Gs-006 strain provided by the invention can produce ginsenoside Rh1 through metabolism, can be subjected to large-scale fermentation culture in a short time, is relatively low in fermentation cost, is not limited by conditions such as time domain and season, and has remarkable advantages. Meanwhile, the invention also provides optimized microbial fermentation conditions and a formula of the culture medium, and the yield of the ginsenoside Rh1 is relatively high.