830 results about "Ginsenoside" patented technology

The invention relates to the technical field of American ginseng quality evaluation, and discloses an American ginseng quality evaluation method based on multi-task deep learning, a computer readable storage medium and a computer program product. The method comprises the following steps: collecting near infrared spectrum data of each American ginseng sample; determining the ginsenoside content of each American ginseng sample to obtain label data of each American ginseng sample; according to the collected near infrared spectrum data and the obtained label data, constructing and training an American ginseng quality detection model; according to the constructed American ginseng quality detection model, producing area tracing and ginsenoside content prediction are carried out on American ginseng to be evaluated. According to the method, the improved multi-task deep neural network is constructed, so that the feature extraction capability is improved, nondestructive origin traceability and total ginsenoside content prediction of American ginseng can be realized at the same time, the detection accuracy and efficiency are improved, and the defects of a traditional method in the aspects of real-time performance and nondestructive detection are overcome.

The invention discloses a ginsenoside Rg3 nano-liposome easier for transdermal absorption as well as a preparation method and application thereof, and belongs to the technical field of liposome preparation. The ginsenoside Rg3 nano-liposome easier to transdermally absorb, provided by the invention, is prepared from the following raw materials in parts by mass: 5 to 20 parts of polyhydric alcohol, 2 to 10 parts of ginsenoside Rg3, 1 to 8 parts of phospholipid, 1 to 5 parts of cholesterol, 1 to 2 parts of resveratrol, 0 to 2 parts of a compound functional substance and 1 to 5 parts of water. The ginsenoside Rg3 nano-liposome easier to transdermally absorb, provided by the invention, has excellent anti-oxidation and anti-inflammatory characteristics through a compound synergistic effect of all the components, can regulate the skin state, comprehensively protect the skin from being damaged by free radicals and inflammation, solves the skin problem caused by external stimulation, and has a good application prospect. The skin care composition has the effects of protecting skin, maintaining skin barrier function, improving skin redness and improving skin stability, can be compounded with any skin care preparation for use, and has wide market application prospect.

The invention belongs to the technical field of medicinal and edible Chinese herbal medicine alcoholic drink, and particularly relates to lactobacillus plantarum and application thereof in fermentation of ginsenoside. The lactobacillus plantarum is specifically lactobacillus plantarum L100, and the preservation number of the lactobacillus plantarum L100 is CGMCC (China General Microbiological Culture Collection Center) No. 34425. The lactobacillus plantarum L100 has the function of converting and preparing the rare ginsenoside, basic components of ginseng can be directionally converted into high-value rare ginsenoside (such as Rg3, Rg5 and Rh1), and particularly, the lactobacillus plantarum L100 has extremely high specificity on generation of F5 and Rh10. Ginseng fermentation liquor obtained by fermenting ginseng through lactobacillus plantarum L100 and extracting solutions of medicinal and edible components such as codonopsis pilosula, astragalus membranaceus, liquorice and cistanche deserticola are used for preparing the liqueur, and a liqueur product with potential effects in the aspects of oxidation resistance, inflammation resistance, immunoregulation and the like is obtained.

The invention discloses a ginseng fermentation product rich in ginsenosides Rg3, Rk1 and Rg5 as well as a preparation method and application of the ginseng fermentation product. Aiming at the problem that the existing ginseng fermentation product has certain effects in the aspects of whitening, resisting anemia, resisting inflammation, delaying cognitive impairment, enhancing the immunity of the organism and the like, but no effect is particularly clear and prominent, the ginseng fermentation product is prepared by fermenting a ginseng fermentation substrate by using a specific probiotic composition; the composition is rich in rare ginsenosides Rg3, Rk1 and Rg5, and the relative content of the ginsenosides Rg3 is high. Experimental research shows that compared with the existing ginseng fermentation product, the ginseng fermentation product disclosed by the invention has a more definite and prominent effect of relieving cognitive impairment. The ginseng fermentation product is simple in preparation method and easy to industrialize, can be widely applied to functional food and other large health fields, and has a wide application prospect.

The invention discloses a ginseng fermentation product rich in various rare ginsenosides and a preparation method of the ginseng fermentation product. Aiming at the problem that the existing ginseng fermentation product has a certain effect in all aspects, but no effect is particularly clear and prominent, the ginseng fermentation product disclosed by the invention is obtained by fermenting a ginseng fermentation substrate by using a microbial strain, and comprises five ginsenosides, namely Rk1, Rg5, Rk3, Rh4 and Rg3, which have the effect of enhancing immunity; the total content of the five ginsenosides is more than 85% by weight, and the total content of the ginsenosides in the ginseng fermentation product is 100% by weight.

The invention discloses fermented lactobacillus mucus NJ-10 and application thereof in preparation of rare ginsenoside-rich metagen through fermentation conversion, and relates to the field of probiotic fermentation. The lactobacillus fermentum NJ-10 is preserved in the China Center for Type Culture Collection on February 25, 2025, and the preservation number of the lactobacillus fermentum NJ-10 is CCTCC (China Center for Type Culture Collection) NO: M 2025300. According to the present invention, the fermentation lactobacillus mucus NJ-10 capable of producing beta-glucosidase, which is subjected to autonomous separation and identification, can be used for fermentation and conversion of ginseng stem and leaf saponin, and then is subjected to post-generation preparation in a high-temperature and high-pressure steam manner, such that the beta-glucosidase producing beta-glucosidase can be produced, and the beta-glucosidase producing beta-glucosidase producing beta-glucosidase producing beta-glucosidase producing beta-glucosidase producing beta-glucosidase can be produced. According to the method, ginseng stem and leaf saponin is converted through two-step fermentation to prepare the postbiotic fermentation product rich in rare ginsenoside, resource utilization of non-medicinal parts of ginseng is expanded, and the postbiotic fermentation product has wide application prospects in the fields of food industry, pharmaceutical industry, cosmetics, animal breeding and the like.

The invention discloses a composition with the effect of relieving cognitive impairment and a preparation method and application thereof. The composition for relieving cognitive impairment comprises a ginseng fermentation product, wherein the ginseng fermentation product is obtained by fermenting a ginseng fermentation substrate using a microbial strain, and contains three ginsenosides Rg3, Rk1 and Rg5, and the total content of the ginsenosides Rg3, Rk1 and Rg5 is greater than or equal to 35% by weight, and the total weight of the ginsenosides in the ginseng fermentation product is 100% by weight; in the ginsenoside Rg3, the ginsenoside Rk1 and the ginsenoside Rg5, the ginsenoside Rg3 is larger than or equal to 40% by weight, and the total weight of the ginsenoside Rg3, the ginsenoside Rk1 and the ginsenoside Rg5 is 100% by weight. Experimental research proves that the composition for relieving the cognitive impairment has a clear and prominent cognitive impairment relieving effect.

The invention discloses a ginseng extract rich in rare saponins and preparation and anti-aging application thereof, and belongs to the technical field of oral beauty and skin care products, the ginseng extract is obtained by fermentation treatment of ginseng powder through phytobacterium plantarum, and the preservation number of the phytobacterium plantarum is GDMCC No.64374. The ginseng extract rich in rare saponin is fermented by specific plant lactobacillus, ginsenoside is efficiently converted into CK and F1, various natural plant components such as ginseng polysaccharide are reserved, and a specific synergistic effect is generated. Through verification, the prepared ginseng extract is high in bioavailability, can more effectively inhibit cell inflammation, and can more effectively recover the mitochondrial function of senescent cells and inhibit cell senescence. The preparation method provided by the invention is high in operability and easy to standardize and intellectualize. Compared with a traditional extraction and purification method, the adopted fermentation method is more environmentally friendly and efficient, and large-scale production can be achieved in industrial production.

The invention provides a red ginseng processing method capable of increasing the content of rare ginsenoside and reducing pesticide residues, and relates to the technical field of medicinal material processing, the red ginseng processing method comprises the following steps: A, steaming fresh ginseng by using atomized probiotic fermentation liquor; b, drying the steamed fresh ginseng to obtain red ginseng; the pH (Potential of Hydrogen) of the probiotic fermentation liquor is 3.0 to 4.0; the OD600 value of the probiotic fermentation liquor is 1.2-2.5, the probiotic fermentation liquor is obtained through probiotic fermentation, the fermentation liquor with the pH value being 3.0-4.0 is adopted as an acid catalyst to replace purified water, in the ginseng steaming process, steaming is conducted through the atomized probiotic fermentation liquor, conversion of ginsenoside is promoted, and meanwhile organophosphorus pesticide residues in ginseng are degraded. The method is safe, efficient, green and natural, and loss of nutritional ingredients and functional ingredients caused by cooking is avoided. The technical problems that red ginseng processed and prepared in the prior art is low in rare saponin content and poor in effect and pesticide residues exist are solved.

The invention belongs to the technical field of cosmetics, and discloses a composition with tightening and anti-wrinkle effects as well as a preparation method and application thereof. The composition disclosed by the invention comprises the following components: a radix pseudostellariae extract and hydrolyzed ginsenoside. The radix pseudostellariae extract in the composition achieves the effects of tightening and resisting wrinkles by promoting generation of collagen and elastin, the hydrolyzed ginsenoside mainly has the effects of resisting oxidation, inhibiting expression of matrix metalloproteinase and preventing collagen degradation, and after the radix pseudostellariae extract and the hydrolyzed ginsenoside are combined, the composition has a better effect of inhibiting the activity of the matrix metalloproteinase, so that the effect of resisting wrinkles is achieved. The traditional Chinese medicine composition has the effects of promoting the generation of collagen and elastin, and has a synergistic effect, so that the traditional Chinese medicine composition has an excellent anti-aging effect.

The invention provides a compound probiotic and qi and blood tonifying fermentation composition and a preparation method and application thereof, and relates to the technical field of microorganisms, the compound probiotic comprises plant lactobacillus KMHD-1 and bifidobacterium longum KMBGI 01, the compound probiotic is adopted for fermentation, the fermentation composition capable of tonifying qi and blood, improving immunity and improving energy can be prepared, and the preparation method is simple and convenient. And the compound probiotics are adopted to ferment the fermentation substrate, so that the variety and content of rare ginsenoside of ginseng can be effectively increased, the content of astragaloside and polysaccharide can be increased, and the efficacy of the product is further enhanced.

The present invention relates to a method for producing a transgenic plant having an increased saponin content. It is confirmed that a nucleotide having a base sequence represented by SEQ ID NO: 1 or 2 derived from ginseng Panax ginseng increases ginsenoside accumulation by regulating the expression of genes involved in ginsenoside biosynthesis. Therefore, the method can be advantageously applied to the production of transgenic plants with increased saponin content.

The present invention relates to the field of biotechnology, and specifically discloses a β-glucosidase and its application in the preparation of ginsenosides. The β-glucosidase of the present invention or a recombinant microorganism expressing the enzyme can generate rare ginsenosides Rg3 and / or Rh1 through whole-cell catalysis, and then the application of the β-glucosidase of the present invention in the preparation of ginsenosides is proposed, and the amino acid sequence of the β-glucosidase is numbered RLF05189.1 on NCBI. The present invention provides a new method for synthesizing ginsenoside Rg3 and / or Rh1, preferably using a whole-cell catalytic method for production, and also has the advantages of short cycle, strong reaction specificity, high yield, low pollution, and simple process.

The invention relates to the technical field of cosmetics, and discloses an anti-inflammatory soothing cosmetic composition which comprises the following components in percentage by weight: 0.5%-4% of a barrier repairing component, 0.5%-3% of an immunoregulation component, 0.3%-2.5% of a nerve soothing component, 0.3%-3% of an anti-inflammatory plant compound, 1%-10% of a moisturizing soothing enhancer and the balance of auxiliary materials. According to the components, through a five-dimensional synergistic mechanism of barrier repair, immune tolerance, nerve desensitization, anti-inflammatory itching relieving, moisturizing and stability maintaining, anti-inflammatory relieving and barrier repair are remarkably enhanced; ceramide, rare ginsenoside, phytosterol ester and free fatty acid are introduced to synergistically construct a bionic liposome which is closer to the composition of human cuticle lipid, so that the transdermal absorption and stability are enhanced, and the repair efficiency is remarkably improved; the dipotassium glycyrrhizinate, the tamarix chinensis flower extract, the purslane extract, the dinoflaxanthine and the baicalin cooperate to quickly resist inflammation and relieve itching and strengthen barrier repair, so that the composition is suitable for highly sensitive skin.

The invention belongs to the technical field of medicine and health care, and particularly relates to a preparation method of an American ginseng root water extract rich in rare ginsenoside and application of the American ginseng root water extract in improving the immune and anti-tumor direction. The preparation method comprises the following steps: step 1, carrying out superfine grinding on American ginseng, and sieving; step 2, adding the American ginseng powder into water, and then adding compound enzyme for enzymolysis to obtain enzymatic hydrolysate; s3, after the enzymolysis is finished, heating the enzymatic hydrolysate, extracting twice, and mixing after the extraction is finished; and S4, inoculating compound lactic acid bacteria into the mixed solution, fermenting to obtain a fermentation solution, blending, and sterilizing to obtain the American ginseng afterbiogen beverage. According to the invention, a new physical-biological combined process is adopted, and crushing, enzymolysis, extraction, fermentation and blending are carried out, so that the American ginseng metagen beverage rich in rare ginsenoside is obtained, and the rare ginsenoside has a remarkable anti-tumor effect and higher activity.

The invention relates to a method for constructing HPLC (High Performance Liquid Chromatography) contents of multi-index components of a reference sample of traditional Chinese medicine powder, which comprises the following steps: step 1, preparation of a reference sample of Kaixin powder: taking polygala tenuifolia, ginseng, poria cocos and rhizoma acori graminei, and crushing into fine powder; 2, preparing a Kaixin powder reference sample and a reference substance detection solution; 3, detecting the Kaixin powder reference sample and the reference substance detection liquid by adopting an HPLC (High Performance Liquid Chromatography) instrument to obtain a chromatogram; and step 4, calculating the content of the effective components in the Kaixin powder reference sample according to the chromatogram. Wherein in the step 3, an HPLC (High Performance Liquid Chromatography) instrument is adopted for detection, and a chromatogram is obtained; comprising the following steps: step A, detecting the contents of polygala # imgabs0 # ketone III, 3, 6 '-dimustard acyl sucrose and beta-asarone in rhizoma acori graminei in polygala tenuifolia; step B, detecting the contents of ginsenoside Rg1, ginsenoside Re and ginsenoside Rb1 in the ginseng; and step C, detecting the content of tenuifolin in the polygala tenuifolia.

The invention relates to the field of ginsenoside extraction, in particular to a device and method for removing a plasticizer in a ginsenoside extract, and the device comprises a roll-over stand, a removal cabin and the like. According to the equipment and the method for removing the plasticizer in the ginsenoside extract, the filtering assembly and the adsorption resin blocks are distributed in the removal cabin in the vertical direction, so that fine filtering treatment and adsorption removal treatment of a ginsenoside extract solution are completed in sequence; and in addition, the filter assembly and the plurality of adsorption resin blocks can be subjected to backwashing treatment in a mutually separated state, so that the overall treatment process steps of the backwashing treatment work are reduced on the basis of ensuring that efficient backwashing treatment is synchronously performed on the filter assembly and all the adsorption resin blocks. The defects that multiple treatment devices need to be used in multiple filtering treatment and ion adsorption treatment processes of the ginsenoside extract solution, the plasticizer removal treatment efficiency is affected, and the plasticizer removal treatment period is delayed are overcome.

The invention relates to a method for producing notoginsenoside and ginsenoside by utilizing panax notoginseng cotyledon embryos, and belongs to the technical field of plant adventitious root tissue culture. The method comprises the following steps: inducing embryogenic calluses by utilizing immature zygotic embryos of panax notoginseng; proliferating the panax notoginseng embryogenic callus on a plate culture medium; s2, putting the pseudo-ginseng embryogenic callus obtained in the step S2 into a liquid culture medium, carrying out cell dispersion, and sieving by using a sieve with the aperture of 24-30 meshes; a mechanical stirring type bioreactor is filled with a liquid culture medium, and the globular embryo and the heart-shaped embryo are placed in the mechanical stirring type bioreactor to be cultured; s3, recovering the filtrate in the step S3, filtering by using a screen with the aperture of 30-80 meshes and 80-150 meshes to obtain uniform panax notoginseng embryogenic cells, and differentiating the panax notoginseng embryogenic cells in a triangular flask for the step S4; and drying the cotyledon embryo obtained in the step S4 at 45 DEG C, and grinding into powder. According to the method, large-scale generation of cotyledon embryos can be completed only in 4-6 weeks, the production process is remarkably accelerated, the method is suitable for industrial batch production requirements, and the production efficiency is high.

The invention discloses a rare ginsenoside dammadienol synthetase and an application of the rare ginsenoside dammadienol synthetase in preparation of dammadienol. The dammadienol synthetase is identified for the first time in the research, a metabolic network of a saccharomyces cerevisiae host cell is modified through a metabolic engineering strategy, genes which do not exist in the host cell are introduced into an engineering strain for heterologous expression, the host cell is changed from nothing to existence, and the dammadienol engineering strain is constructed. In addition, through homologous modeling, key catalytic pocket searching and key enzyme gene site-directed mutagenesis modification, enzyme catalysis efficiency is improved, efficient synthesis of dammadienol is achieved, the problem that natural sources of the rare ginsenoside are insufficient is solved, green synthesis and sustainable utilization of the rare ginsenoside are promoted, and the method is suitable for industrial production. And a foundation is laid for subsequent construction of rare ginsenoside cell factories.

The ginsenoside F4 is found to be capable of effectively down-regulating the expression of osteogenic differentiation marker genes ALP and RUNX2 in valvular interstitial cells and inhibiting the osteogenic differentiation of the valvular interstitial cells, so that valve calcification is delayed or inhibited; the invention also provides a cell-tissue-individual three-dimensional culture system which can significantly improve osteogenic differentiation of valvular interstitial cells, human aortic valve tissue blocks and Apoe- / -male mouse aortic valves after being treated by ginsenoside F4, and further provides a new drug choice for prevention and treatment of calcified aortic valve diseases.

The embodiment of the invention provides a method for converting ginsenoside in ginseng adventitious roots, which comprises the following steps: (a) taking liquid-cultured ginseng adventitious roots as raw materials, taking the ginseng adventitious roots out of a liquid culture medium, cleaning and removing the residual liquid culture medium on the surfaces of the ginseng adventitious roots, and removing moisture on the surfaces of the ginseng adventitious roots; and (b) suspending the ginseng adventitious roots obtained in the step (a) in high-temperature and high-pressure equipment, adding water into the bottom of the high-temperature and high-pressure equipment, heating to generate high-temperature and high-pressure steam to carry out high-temperature and high-pressure conversion on the ginseng adventitious roots, and controlling reaction parameters to obtain finished ginseng adventitious roots with the rare ginsenoside content obviously improved.

The invention belongs to the technical field of medicines, and particularly relates to a secondary ginsenoside composition and application thereof in prevention and treatment of pulmonary fibrosis and acute lung injury. The secondary ginsenoside composition is prepared from any two or more components selected from the following components: (20S)-Rg2, (20S)-Rh1, (20R)-Rg2, (20R)-Rh1, Rg6, F4, Rk3 and Rh4; (20S)-Rg3, (20R)-Rg3, Rk1, Rg5, (20S)-Rh2, (20R)-Rh2, Rk2 and Rh3 are selected from the group consisting of (20S)-Rg3, (20R)-Rg3, Rk1 and Rg5. The medicine effect of the secondary ginsenoside composition provided by the invention on the aspects of preventing and treating pulmonary fibrosis and acute lung injury is obviously superior to that of a primary ginsenoside composition and secondary saponin Rg5 and Rg3 monomer components. Meanwhile, the secondary ginsenoside composition is more easily absorbed by intestinal tracts than a primary ginsenoside composition, and is slightly influenced by individual differences of intestinal flora. Compared with a secondary saponin monomer component, the compound is easier to prepare, lower in production cost and safer and more efficient compared with existing commercially available drugs.

The invention discloses a high-utilization-rate ginseng active ingredient medicinal preparation and a preparation method thereof, and relates to the technical field of medicines. The high-utilization-rate ginseng active ingredient pharmaceutical preparation is prepared from chitosan coated drug-loaded porous silicon dioxide composite nanoparticles and a drug-loaded MIL-101 metal organic framework matrix material, chitosan-coated drug-loading porous silicon dioxide composite nanoparticles are loaded on the surface of a drug-loading MIL-101 metal organic framework base material, and sodium alginate and a chitosan gel material are subjected to cross-linking connection, so that independent coating is formed, the framework base material and the composite nanoparticles are connected into a whole, the encapsulation performance and the drug loading capacity are improved, and the drug-loading capacity of the drug-loading MIL-101 metal organic framework composite nanoparticles is improved. Furthermore, the loading and the loading stability of the ginsenoside are improved, the adverse effects of gastric juice and gastrointestinal peristalsis on the activity of the ginsenoside are effectively reduced, the release and the absorption of the ginsenoside in intestinal tracts are remarkably enhanced, and the bioavailability is relatively high.

The invention belongs to the technical field of biological medicines, and relates to streptococcus thermophilus with a rare ginsenoside conversion effect and application of the streptococcus thermophilus. The strain is Streptococcus thermophilus 17140, the Streptococcus thermophilus 17140 is preserved in the Guangdong Microbial Culture Collection Center (GDMCC) on September 23, 2024, and the preservation number of the Streptococcus thermophilus 17140 is GDMCC NO.65173. The invention further discloses a preparation method of the Streptococcus thermophilus 17140. The strain disclosed by the invention has good functions of fermenting and converting various ginsenosides and notoginsenoside and generating rare ginsenosides.

The invention discloses a ginsenoside hydrogen sulfide donor derivative as well as a preparation method and application thereof, and belongs to the technical field of natural medicines and medicinal chemistry. According to the invention, a series of ginsengenin hydrogen sulfide donor derivatives are designed and synthesized by taking ginsengenin as a lead compound, and the myocardial protection activity of the synthesized derivatives is tested; results show that the ginsenoside hydrogen sulfide donor derivative prepared by the invention has relatively good heart protection activity for treating myocardial ischemia, arrhythmia and myocardial infarction, and has the potential of serving as a heart protection medicine.

The invention discloses a method for synthesizing rare ginsenoside by converting natural ginsenoside Rb1 with endophytic fungi separated from root rot ginseng. The method comprises the following steps: obtaining a Fusarium redolics c271F from root rot ginseng by utilizing a fungus separation method, carrying out conversion synthesis on a zymophyte of the Fusarium redolics c271F by taking ginsenoside Rb1 as a raw material to obtain rare saponins, and identifying the converted rare saponins as F2, Rg3 and CK on the basis of an HPLC (High Performance Liquid Chromatography) method. The method disclosed by the invention is simple to operate, green and safe, relatively high in yield and relatively low in cost, and a new method is provided for industrial production of the rare ginsenoside.

The invention discloses an application of burkholderia in root system microorganisms in regulation and control of glycosylation of ginsenoside. The invention provides application of burkholderia or a composition containing the burkholderia in any one of the following applications: 1) regulating and controlling proportions of different glycosylated saponins in ginseng; 2) increasing the proportion of monoglycosylated saponin and / or the proportion of disglycosylated saponin in ginseng; 3) preparing ginseng with a high monoglycosylated saponin ratio and / or a high disglycosylated saponin ratio; and 4) improving ginseng cultivation. In a greenhouse environment, the roots of ginseng seedlings are inoculated with burkholderia, metabolome data shows that the burkholderia regulates glycosylation formation of ginsenoside, and the proportion of monoglycosylated saponin and / or the proportion of disglycosylated saponin can be increased. Further, transcriptome sequencing data analysis shows that the burkholderia regulates and controls the expression of different glycosyl transferases, so that the diversity of glycosylation of ginsenoside is influenced. The burkholderia provides a new thought for refined improvement of a ginseng cultivation technology.

The invention belongs to the technical field of biological agents, and particularly relates to ginsenoside variant flavobacterium DG-16 and application thereof in relieving continuous cropping obstacles of angelica sinensis and improving the quality of the angelica sinensis. According to the ginsenoside variant flavobacterium DG-16 disclosed by the invention, the growth of angelica sinensis is promoted by increasing the contents of jasmonic acid and cytokinin hormones, reducing the contents of gibberellin and salicylic acid hormones and promoting the circulation and utilization of nitrogen; in addition, the flavobacterium ginsenoside variant DG-16 can significantly increase the chlorophyll content, is beneficial to photosynthesis of the angelica sinensis, effectively changes the physiological and biochemical states of the angelica sinensis, can resist root rot of the angelica sinensis so as to relieve successive cropping obstacles and improve the quality, and has a significant effect.

The invention provides a platelet membrane bionic nano-drug delivery system as well as a preparation method and application thereof, and relates to the technical field of medicines. According to the invention, through membrane engineering modification, a wrapping material obtained through hybridization of a platelet membrane and an NK cell exosome is used for loading ginsenoside Rg3 for the first time, a ginsenoside Rg3 delivery system with high encapsulation efficiency and high drug loading capacity is obtained, and the system has excellent stability and can be stored for a long time in normal-temperature and high-temperature environments; the ginsenoside Rg3-loaded platelet membrane bionic nano-drug delivery system is simple in preparation method and suitable for wide popularization and application; according to the ginsenoside Rg3-loaded platelet membrane bionic nano-drug delivery system, the lung cancer treatment effect of ginsenoside Rg3 can be effectively improved, a novel drug is provided for lung cancer treatment, and the drug is high in safety, high in biocompatibility, free of adverse reaction in the treatment process and obvious in anti-inflammatory effect.

The invention discloses a ginseng and nattokinase composition and a preparation method thereof, belongs to the technical field of microbial fermentation, and provides the ginseng and nattokinase composition which comprises ginsenoside, ginseng peptide, acid-soluble protein, a stabilizer, an additive and a ginseng body. The preparation method comprises the following steps: S1, cleaning ginseng, crushing, cooking, cooling to 25-36 DEG C, and standing for 24 hours to obtain cooked ginseng; s2, adding an auxiliary agent and a stabilizer into the ginseng cooked in the step S1, then inoculating bacillus natto, and culturing for 24-36 hours at the temperature of 32-35 DEG C to obtain fermentation liquor; and S3, adding the auxiliary agent into the fermentation liquid in the step S2 again, uniformly mixing, culturing for 24-48 hours at the temperature of 36-40 DEG C, and then drying at low temperature to obtain the ginseng and nattokinase composition. The preparation method is simple and easy to popularize.