423 results about "Lactobacillus acidophilus" patented technology

The invention relates to the technical field of health care products, and discloses kidney function health wine based on traditional Chinese medicine fermentation and a preparation method of the kidney function health wine. 6-10 parts of cistanche deserticola; 9-30 parts of radix astragali and 6-12 parts of fructus lycii; the fermentation strain comprises lactobacillus acidophilus, lactobacillus plantarum, bifidobacterium longum subsp. Longum, saccharomyces cerevisiae and bacillus subtilis, and the fermentation strain comprises the following strains: lactobacillus acidophilus JYLC-374, lactobacillus plantarum JYLC-482, bifidobacterium longum subsp. Longum JYBB-163, saccharomyces cerevisiae JYSC-710 and bacillus subtilis JYBS-312. By adopting the technical scheme that a traditional Chinese medicine compound formula is combined with specific probiotic fermentation, the technical effects of enhancing the bioavailability of active ingredients and promoting kidney function regulation are achieved, and the dissolution rate and the biotransformation rate of herbal medicine active substances are improved.

The invention relates to the technical field of pharmaceutical preparations, and discloses a composition with liver protection and antioxidation effects and a preparation method thereof.The composition is prepared from galactosamine modified astragalus membranaceus exosome, schisandra chinensis nanocrystals, liquorice-chitosan nanoparticles, lactobacillus acidophilus freeze-dried powder, beta-(1, 3) / (1, 3, 4-tetramethyl-1, 3-pentanediol monoisobutyrate) sourced from saccharomyces cerevisiae, and beta-(1, 3, 4-tetramethyl-1, 3-pentanediol monoisobutyrate). And (6) a dextran, grape exosome-curcumin hybrid vesicle freeze-dried powder, a curcumin-mitochondrial targeting peptide compound, a resveratrol-hydroxypropyl-beta-cyclodextrin inclusion compound and reduced panthenol. According to the liver-protecting and anti-oxidation composition disclosed by the invention, multi-dimensional intervention on liver protection is realized through an elaborately designed ternary system. The system is composed of a traditional Chinese medicine extract, a microorganism-plant exosome combination and a high-bioavailability antioxidant, all the parts have a synergistic effect, and the liver protection effect is remarkably improved.

The invention belongs to the technical field of microorganisms, and particularly relates to a postbiotic preparation for pets as well as a preparation method and application of the postbiotic preparation. The metabolite preparation provided by the invention comprises a lactobacillus plantarum Ps-8 inactivated thallus and a metabolite thereof, a lactobacillus casei C-9 inactivated thallus and a metabolite thereof, a bifidobacterium animalis subsp. Lactis BB-16 inactivated thallus and a metabolite thereof, and a lactobacillus acidophilus LA-14 inactivated thallus and a metabolite thereof. The pet food can be applied to various food types of different varieties of cat and dog pets, and has the effects of improving the intestinal barrier function of the pets, enhancing the immunity, reducing the incidence rate of diarrhea, reducing the food change stress, promoting the digestion of nutrient substances, optimizing the state of spirit and fur, reducing the odor of excrement, fading the odor of the oral cavity, improving the health level of the oral cavity and teeth and the like.

The invention relates to the field of microorganisms, and discloses a strain of lactobacillus acidophilus and application of the lactobacillus acidophilus in preparation of drugs for preventing and / or treating hyperlipidemia and hyperglycemia, the preservation number of the lactobacillus acidophilus is CGMCC No.33155, the strain can generate lactic acid, is resistant to acid and cholate, and has strong self-aggregation ability and hydrophobic ability. The strain provided by the invention can promote the decomposition of fat and sugar by degrading cholesterol and inhibiting the activity of alpha-glucosidase and alpha-amylase, can reduce the expression levels of blood sugar, blood fat and inflammatory factors of hyperlipidemia and hyperglycemia mice, and provides a new idea for preparing medicines for preventing and / or treating hyperglycemia and hyperlipidemia.

The invention relates to the technical field of food, and particularly discloses a compound prebiotics embedded probiotic microcapsule and a preparation method and application thereof.The green tea leaves serve as main raw materials, water extraction is conducted on the green tea leaves, meanwhile, ultrasonic-assisted treatment is adopted, active ingredients in the green tea leaves can be more effectively released, the extraction time is shortened, and the content of probiotics in the green tea leaves is increased; the extraction rate of active ingredients in the green tea leaves is improved; then, lactobacillus acidophilus is adopted to ferment the extract liquid, so that the green tea fermentation liquid contains more antioxidant active ingredients, combined polyphenol in the extract liquid can release micromolecular polyphenol in the fermentation process, the content of substances such as flavone and polyphenol in the green tea fermentation liquid is increased, and the antioxidant activity is further improved; and then the modified dietary fiber is used as a main wall material of the microcapsule to embed the green tea fermentation liquor and the probiotics, so that the stability of active substances and the probiotics in the green tea fermentation liquor is improved, and the green tea fermentation liquor can play a role in protection and slow release in the simulated digestion process.

The invention discloses a composition for treating insomnia. Comprising probiotic compounds: lactobacillus plantarum, bifidobacterium lactis, lactobacillus crispatus, lactobacillus acidophilus, lactobacillus rhamnosus, bifidobacterium bifidum, lactobacillus reuteri, lactobacillus casei, lactobacillus bulgaricus, lactobacillus fermentum, lactobacillus gasseri, lactococcus lactis, bifidobacterium longum, lactobacillus salivarius, bifidobacterium breve, streptococcus thermophilus and lactobacillus paracasei; lactobacillus helveticus; and traditional Chinese medicine components and prebiotics. Probiotics are matched with traditional Chinese medicines with homology of medicine and food, and corresponding prebiotics are supplemented, so that the balance of intestinal flora can be adjusted and information transmission between intestines and cranial nerves can be promoted through the synergistic effect of the probiotics and the corresponding prebiotics, and then gastrointestinal inflammation, ulcer, helicobacter pylori infection, constipation and insomnia are treated or improved; and treating or improving spleen and stomach disharmony, liver qi stagnation, excessive heart fire, fire excess from yin deficiency, heart-kidney disharmony caused by emotion, pressure, diseases and the like, and insomnia caused by the symptoms.

The invention relates to the technical field of functional beverage processing, in particular to a method for preparing ginger black tea by combining fresh ginger pretreatment with black tea probiotic fermentation, a ginger black tea product and application of the ginger black tea product. The method comprises the following steps: a) fresh ginger enzymolysis pretreatment: fresh ginger is subjected to enzymolysis treatment to reduce the gingerol content; b) microencapsulation of gingerol: preparing the ginger liquid subjected to enzymolysis, sodium alginate and chitosan into microcapsules; c) black tea extraction: performing water extraction on black tea to prepare black tea liquid; d) probiotic activation: carrying out activation culture on lactobacillus acidophilus and lactobacillus plantarum; e) performing multi-stage fermentation: mixing the black tea liquid, gingerol microcapsules and activated probiotics, and performing fermentation through multi-stage temperature and pH control; (f) post-processing the product, namely post-processing the fermentation liquor to obtain the probiotic-containing ginger black tea product, so that the effective components of the ginger are reserved while the content of spicy components of the ginger is reduced.

The invention relates to the field of biotechnology and female health care, in particular to a stachyose composition for promoting micro-ecological regulation of lactobacillus and application of the stachyose composition, and the composition comprises stachyose and pharmaceutically acceptable auxiliary materials. The stachyose is used as prebiotics to selectively promote proliferation and colonization of the lactobacillus crispatus, the combination of 1%-5% of the stachyose and 0.1%-0.5% of the lactic acid can promote proliferation of the lactobacillus crispatus, the lactobacillus crispatus is one or more of the lactobacillus crispatus, the lactobacillus plantarum and the lactobacillus acidophilus, and the combination of 1%-5% of the stachyose and 0.1%-0.5% of the lactic acid can inhibit gardnerella and candida albicans. The stachyose composition disclosed by the invention is in the form of slow-release gel and bath foam; the composition can be used for treating or preventing bacterial vaginitis, colpitis mycotica and related symptoms, has the advantages of no antibiotics, no drug resistance, high safety and the like, and is suitable for the fields of vagina local nursing and micro-ecological regulation.

The invention discloses a functional probiotic composition and application thereof, and relates to the technical field of microbial engineering. Bifidobacterium longum, lactobacillus acidophilus and enterococcus faecalis are combined to serve as a microbial agent, the microbial agent and active substances of the tea leaves form a composition, then the composition is combined with prebiotics, it is ensured that viable bacteria directly reach the intestinal tract through a microencapsulation technology, and the effect of improving the immune function is achieved; tea polyphenol in the active substances of the tea leaves can serve as a carbon source of prebiotics to stimulate proliferation of the bifidobacterium longum and the lactobacillus acidophilus, so that the acid resistance and intestinal colonization capacity of the microbial inoculum are enhanced, and meanwhile, theanine in the active substances of the tea leaves, the bifidobacterium longum and the lactobacillus acidophilus synergistically promote secretion of gamma-aminobutyric acid, so that the effect of improving the intestinal colonization is achieved. And the tea polyphenol can inhibit the large intestine rod from adhering to the intestinal mucosa, and the probiotic agent secretes antibacterial peptide, so that the integrity of the intestinal barrier is maintained together.

The present invention relates to a composite postbiotic agent for promoting vaginal microecological balance and its application, wherein the strains in the composite postbiotic agent for promoting vaginal microecological balance include inactivated LA88 strain and inactivated N13 strain. The present invention has developed a new probiotic intervention strategy for promoting vaginal microecological balance, that is, inactivating Lactobacillus acidophilus Lactobacillus acidophilus LA88 strain and inactivated Lactobacillus plantarum Lactobacillus plantarum The N13 strain is compounded to form a new composite postbiotic agent, which has a good proliferation effect on a variety of beneficial vaginal bacteria, a strong inhibitory effect on a variety of vaginal pathogenic bacteria, and can promote the restoration of a healthy microbial community structure.

The invention discloses a composite microbial preparation for treating obesity of pet dogs and application of the composite microbial preparation, and belongs to the technical field of microbial preparations. The compound microbial preparation is prepared by fermenting lactobacillus acidophilus L100 and lactobacillus reuteri GBW1146, and the preservation number of the lactobacillus reuteri GBW1146 is CGMCC (China General Microbiological Culture Collection Center) No. 34455. The compound microbial preparation is prepared by fermenting lactobacillus acidophilus L100 and lactobacillus reuteri GBW1146. The compound microbial preparation can remarkably reduce digestion and absorption of intestinal tracts of dogs on fat and reduce triglyceride and cholesterol levels in blood, so that the average food intake and average calorie consumption of the dogs are reduced, and finally the effect of reducing obesity of the pets is achieved. The compound microbial preparation provided by the invention enhances the competitiveness of the pet feed additive and series products thereof in China in the international market, and has a wide application prospect.

The invention belongs to the technical field of probiotic particles, and particularly relates to probiotic particles for improving intestinal functions as well as a preparation method and application of the probiotic particles. The probiotic particles capable of improving the intestinal function comprise a probiotic core, a first embedding layer, a second embedding layer and a third embedding layer, the probiotic inner core is prepared from plant lactobacillus, bifidobacterium animalis, lactobacillus acidophilus, bifidobacterium longum, lactobacillus paracasei, lactobacillus rhamnosus, lactobacillus fermentum, lactobacillus helveticus, streptococcus thermophilus, plant lactobacillus, lactobacillus helveticus and lactobacillus rhamnosus. According to the present invention, the twelve probiotics are contained, and the latest three-layer embedding technology is adopted so as to enhance the storage property and the digestive tract tolerance, such that the product can maintain the beneficial bacterium activity for a long time without refrigeration, and the product is suitable for the crowd with the alteration of the intestinal flora.

The invention provides a lactobacillus acidophilus HX-LA15 with strong antioxidant activity, the preservation number of the lactobacillus acidophilus HX-LA15 is CGMCC (China General Microbiological Culture Collection Center) No.32954, and the lactobacillus acidophilus HX-LA15 is preserved in China General Microbiological Culture Collection Center on December 23, 2024. Meanwhile, the invention further provides a compound fermentation product of the lemon myrtle leaves and the herba cistanche, a probiotic preparation containing the lactobacillus acidophilus HX-LA15 and the compound fermentation product as well as a preparation method and application of the probiotic preparation. The lactobacillus acidophilus HX-LA15 provided by the invention has a remarkable scavenging capability on free radicals, and compared with other probiotics, the lactobacillus acidophilus HX-LA15 can be used for remarkably increasing the content of cistanoside A and polyphenol compounds in a compound fermentation product after fermenting the lemon myrtle leaves and the cistanche; therefore, the fermented product has the function of improving reproductive function decline and reproductive aging of mice with kidney-yang deficiency, and has a good application prospect.

The invention discloses a method for quantitatively detecting viable bacteria of lactobacillus reuteri, lactobacillus rhamnosus, lactobacillus paracasei and lactobacillus acidophilus. The novel molecular detection target disclosed by the invention has high specificity on target bacteria. The disclosed PMA-qPCR method comprises the steps of target detection, qPCR primer and probe design, qPCR detection system, PMA treatment condition and viable bacteria quantitative standard curve. After qPCR amplification, if a Cq value appears, the dissolution peak is single and the dissolution temperature is consistent with that of a positive sample (only aiming at a dye method), the lactic acid bacteria are identified as target lactic acid bacteria, and the number of viable bacteria can be calculated according to a corresponding standard curve. The method can effectively detect and count viable bacteria of Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus paracasei and Lactobacillus acidophilus, has the advantages of rapidness, accuracy, simple operation and the like, and is convenient for food enterprises and inspection institutions to use.

A composition includes postbiotics comprising two or more of the following components: Lactobacillus acidophilus, Lactobacillus rhamnosus, and Saccharomyces boulardii; wherein the postbiotics are dead, whole-cell postbiotics. A method of providing to a subject an immunomodulatory, immune regulatory and / or immune boosting effect through administering the composition is also provided. A method of making the postbiotic composition is also provided.

The invention discloses a microbial compound feed for improving disease resistance of blue crabs and a preparation method of the microbial compound feed, and belongs to the technical field of feed preparation. The microbial compound feed comprises the following raw materials in parts by weight: 30-40 parts of fermented soybean meal, 20-25 parts of bran, 15-20 parts of fish meal, 5-8 parts of a compound microbial agent, 3-5 parts of algal polysaccharides, 2-3 parts of a radix astragali extract, 1-2 parts of chitosan, 2-3 parts of a mineral premix and 1-1.5 parts of compound vitamins, wherein the compound microbial agent comprises bacillus licheniformis, lactobacillus acidophilus and saccharomyces cerevisiae. The microbial compound feed disclosed by the invention comprehensively improves the disease resistance of the blue crabs and improves the survival rate through various ways, such as nutrition balance, immune regulation and intestinal health improvement, so that the breeding cost is reduced, and the income of farmers is increased.

The present application belongs to the technical field of biological fermentation, and discloses a natural plant fermentation liquor, which is prepared from acanthopanax, angelica sinensis, rosa davurica, phellinus baumii, tea leaves, water, mixed enzymes and mixed bacterial agents; wherein the mixed enzymes include cellulase, pectinase and tannase, and the mixed bacterial agents include lactobacillus plantarum, schizosaccharomyces and lactobacillus acidophilus.The natural plant fermentation liquor has high safety, good clarity after adjusting the concentration of crude drugs, and can be added into a cosmetic matrix.The preparation method is simple, and the effective active ingredients of the natural plants and tea leaves are extracted by the synergistic effect of bacteria and enzymes to the maximum extent.In addition, the present application also discloses the application of the natural plant fermentation liquor in preparing cosmetics for treating oily sensitive skin.

The present invention relates to a prebiotic feed additive for promoting intestinal health of pigs, belonging to the technical field of feed, the prebiotic feed additive of the present invention comprises prebiotic components and biological adjuvants, the prebiotic components comprise oligofructose, oligoisomaltose, inulin and resistant dextrin, the biological adjuvant is a product obtained by co-enzymatic hydrolysis of dandelion and houttuynia cordata by hemicellulase and pectinase, then fermented by Lactobacillus acidophilus and Propionibacterium freudenreichii in sequence, and finally enzymatic hydrolyzed by bromelain and trypsin step by step. The components in the additive are used in combination to have a good effect of promoting intestinal health of pigs, can balance and improve the intestinal microenvironment, improve feed nutrient utilization, enhance immunity, reduce diarrheal diseases, and promote growth and weight gain.

The invention discloses a processing method of fermented cottonseed meal for replacing soybean meal. The method comprises the following steps: uniformly mixing cottonseed meal, feather meal, corn starch and water to obtain a fermentation substrate, adding a first-stage fermentation inoculant into the fermentation substrate for aerobic fermentation, adding a second-stage fermentation inoculant for anaerobic fermentation after fermentation is finished, and performing low-temperature drying and crushing on a fermentation product after fermentation is finished to obtain the cottonseed meal fermented feed. The first-stage fermentation inoculant comprises candida utilis, aspergillus oryzae, papain and cellulase; and the second-stage fermentation inoculant comprises lactobacillus reuteri and lactobacillus acidophilus. According to the method, a bacterium-enzyme synergistic two-step fermentation mode is adopted, bacterium-enzyme synergistic aerobic fermentation is carried out firstly, then anaerobic fermentation is carried out with compound probiotics, and the obtained cottonseed meal fermented feed is high in crude protein and amino acid content and good in palatability, can completely replace soybean meal, can effectively regulate fat metabolism and can improve the lean meat percentage of fattening pigs.

The invention belongs to the technical field of agricultural microbial agents, and relates to an agricultural liquid microbial agent preparation method and a microbial agent, the method comprises the following steps: mixing bacillus amyloliquefaciens and trichoderma reesei, and carrying out primary aerobic fermentation; mixing a product subjected to primary aerobic fermentation with lactobacillus acidophilus subjected to expanding culture, and carrying out secondary micro-aerobic fermentation; and carrying out membrane separation treatment on the product subjected to secondary microaerobic fermentation, and concentrating the bacterial liquid. According to the microbial agent, through the synergistic effect of multiple strains, the inhibition rate of soil-borne pathogenic bacteria is increased, the occurrence rate of crop rhizosphere diseases is reduced, and then the yield and quality of crops are synergistically optimized. High-activity flora is reserved through gradient fermentation and membrane separation technologies, the continuous colonization capacity of thalli in deep soil is maintained in combination with biochar, a long-term stable field protection barrier can still be formed through flora interaction even if mechanical turning is not needed, and therefore disease prevention and control are achieved under the no-tillage or minimal-tillage condition.

The invention relates to an application of a compound microbial agent in promoting phosphorus and potassium solubilization of soil and increasing the content of available phosphorus and potassium in the soil. The bacterial strains in the compound microbial agent consist of a bacillus coagulans BC66 bacterial strain, a lactobacillus plantarum LP194 bacterial strain and a lactobacillus acidophilus LA71 bacterial strain. The invention also relates to an application of the compound microbial agent in promoting phosphorus and potassium solubilization of the soil and increasing the content of available phosphorus and potassium in the soil, and the bacterial strains in the compound microbial agent consist of a bacillus coagulans BC66 bacterial strain, a lactobacillus plantarum LP194 bacterial strain and a lactobacillus acidophilus LA71 bacterial strain. The invention develops a brand-new microbial preparation capable of promoting the phosphorus and potassium solubilizing effect of soil, and researches find that the three strains are mutually matched and have synergistic interaction on the effects of promoting phosphorus and potassium solubilizing of soil, improving the content of available phosphorus and potassium in soil, improving the utilization rate of phosphate fertilizer and potassium fertilizer and increasing the yield of fruit trees, and the yield of the fruit trees is increased under the condition that the using bacterium amount is consistent. Compared with a single strain intervention mode or other strain combined intervention mode, the microbial preparation has the advantage that the effects are obviously improved. Therefore, the compound microbial agent provides a new strategy for promoting phosphorus and potassium solubilization of soil, increasing the content of available phosphorus and potassium in soil, increasing the utilization rate of phosphate fertilizer and potassium fertilizer and increasing the yield of fruit trees.

The invention provides a probiotic composition as well as a preparation method and application thereof. The composition is prepared from lactobacillus rhamnosus GG, lactobacillus acidophilus NCFM, an anti-IL-4R alpha monoclonal antibody, an inulin-beta-glucan compound and sodium alginate-chitosan microspheres. The composition regulates immune balance through a specific probiotic strain, blocks an IL-4 / IL-13 signal channel in combination with an anti-IL-4R alpha monoclonal antibody, and improves viable bacterium stability and bioavailability through a microsphere delivery technology. The probiotic composition shows a remarkable anti-allergic effect in an atopic dermatitis mouse model, and can reduce the serum IgE level, reduce the skin inflammatory response and reduce the STAT6 phosphorylation level. The probiotic composition disclosed by the invention has a wide application prospect in the aspect of treating atopic dermatitis and other immune-related diseases.

The invention belongs to the technical field of microbial fermentation, discloses a method for multi-bacterium synergistic fermentation of roxburgh rose juice, and particularly discloses a microbial agent which comprises rhizopus arrhizus CLF001 and at least one of pediococcus pentosaceus, lactobacillus plantarum, acetic acid bacteria, saccharomycetes and lactobacillus acidophilus. According to the microbial agent provided by the invention, the content of polysaccharide, polyphenol, brass and the like can be remarkably increased and the content of tannin in the roxburgh rose normal juice can be reduced by fermenting the roxburgh rose normal juice for 3 days by using the microbial agent, so that the fermented roxburgh rose normal juice does not feel obvious astringent taste, and the bitterness of the roxburgh rose normal juice is greatly improved; when the microbial agent is used for fermentation, polyphenol substances such as tannin with heavy astringent taste in the roxburgh rose normal juice are converted into non-astringent polyphenol substances, the taste of the normal juice is improved, the content of active ingredients is increased, for example, key ingredients (such as polyphenol, flavone and polysaccharide) capable of remarkably improving the antioxidant activity in the roxburgh rose normal juice can be used for improving the antioxidant performance of the roxburgh rose normal juice.

The invention relates to a composition of seven probiotics for improving immunity and application of the composition. The bacterial strains in the probiotic composition comprise a combination of a streptococcus thermophilus CT-02 bacterial strain, a bifidobacterium animalis subsp. Lactis C-2 bacterial strain, a bifidobacterium longum subsp. Infantis C-3 bacterial strain, a lactobacillus delbrueckii subsp. Bulgaricus CB-01 bacterial strain, a lactobacillus acidophilus CL-01 bacterial strain, a lactobacillus paracasei CL-02 bacterial strain and a lactobacillus rhamnosus CL-03 bacterial strain. Potential interaction exists among the seven strains, the seven strains can be mutually matched and synergistically interacted when being combined, and the seven strains have excellent effects in the aspects of improving immunity, relieving inflammatory response, improving the health degree of the intestinal environment and the like.

The invention relates to the field of vinegar wine production, and discloses a vinegar wine formula with beauty maintaining and young keeping functions and a preparation method thereof.The preparation method comprises the following steps that S1, raw material pretreatment is conducted, specifically, finished rice wine fermented for one month is filtered through a filter screen to remove rice wine residues; s2, secondary fermentation: adding lactobacillus plantarum into the finished product rice wine for secondary fermentation; s3, tertiary fermentation: taking out the liquid after the secondary fermentation, and adding lactobacillus acidophilus for tertiary fermentation; and S4, post-treatment: disinfecting a filling container, and filling the finished product vinegar wine into the filling container by using a filling machine for storage. According to the present invention, the rice wine, the lactobacillus plantarum and the lactobacillus acidophilus are scientifically proportioned, and the double-bacterium step-by-step fermentation process is adopted, such that the synergistic output of a variety of active substances is achieved; lactic acid and gamma-aminobutyric acid (GABA) are enriched through secondary anaerobic fermentation, lactobacillus acidophilus is induced to generate exopolysaccharides through third-time micro-aerobic fermentation, and the effects of the product in the aspects of nutritional supplement, beauty maintaining and young keeping are remarkably enhanced.

The invention belongs to the technical field of food engineering, and particularly relates to an anti-allergic special medical infant milk protein partial hydrolysis formula food composition, a preparation method and application. According to the infant milk protein partial hydrolysis formula food composition for the special medical purpose, the mass ratio of the 2 '-fucosyllactose to the lactobacillus acidophilus NCFM to the bifidobacterium animalis Bi-07 is (150-200): (5-10): (2-8). The partially hydrolyzed formula food composition provided by the invention can prevent respiratory tract infection and maintain the natural defense capability of children; the infant health is promoted; the method helps infants to establish healthy intestinal microflora, which is crucial to immune system and cognitive development.

The invention belongs to the technical field of microorganisms, and relates to lactobacillus acidophilus LA4 and application thereof. The classification name of the lactobacillus acidophilus LA4 is lactobacillus acidophilus, the lactobacillus acidophilus LA4 is preserved in the China General Microbiological Culture Collection Center (CGMCC) on July 9, 2025, and the preservation number of the lactobacillus acidophilus LA4 is CGMCC No.35144; the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The strain can significantly improve cognitive impairment of an elderly behavior cognitive impairment model mouse and enhance the learning and memory ability of the mouse by reducing deposition of beta amyloid protein in the brain of the mouse, inhibiting the activity of acetylcholin esterase, regulating and controlling the neurotransmitter level, relieving brain inflammatory response, reducing nerve injury, promoting synaptic regeneration and the like. The strain provided by the invention provides a potential treatment scheme for preventing or improving senile behavioral cognitive impairment, and has important development and application values.

The invention belongs to the related technical field of pet prescription food products, and particularly relates to a prescription food for pet dogs with acute intestinal inflammation and a preparation method of the prescription food, the prescription food comprises various components such as rice, barley, chicken powder and corn protein powder, and probiotics are self-made and comprise bifidobacterium, lactobacillus acidophilus and lactobacillus casei. The preparation method comprises the steps of quantitative raw material weighing, auxiliary agent grinding, constant-temperature accurate grinding, adding of specific components for accurate grinding again, heat preservation, deodorization and degassing, drop casting forming, cooling, packaging, sealed storage and the like. Compared with the prior art, the prescription food is high in safety, and feeding tests of healthy dogs have no abnormity; clinical cases show that the leucocyte number and the inflammatory factor content of sick dogs can be reduced; the intestinal barrier can be repaired, so that the intestinal mucosa repair is accelerated; intestinal flora can be improved, and the content of short-chain fatty acid in excrement is increased; the nutrition state can be maintained, and the weight loss range of sick dogs is reduced.

The invention discloses an anti-wrinkle firming composition and application thereof, and particularly belongs to the technical field of skin care products. The composition is prepared from the following components in parts by mass: 0.1 to 10 parts of rhodiola rosea extract, 5 to 20 parts of hydroxypropyl tetrahydropyrantriol, 0.02 to 2 parts of polyrock extract and 0.5 to 2 parts of adenosine, wherein the polyrock extract is obtained by carrying out compound fermentation on lactobacillus acidophilus and bacillus licheniformis; according to the anti-wrinkle and firming composition provided by the invention, when the rhodiola rosea extract, the hydroxypropyl tetrahydropyrantriol, the polyrock extract and the adenosine are compounded for use, excellent effects of resisting oxidation and promoting collagen synthesis are shown; the anti-wrinkle and firming emulsion provided by the invention can effectively reduce wrinkles and improve skin elasticity, shows excellent performance, overcomes the problems of efficacy limitation and single action mechanism of a single component, and realizes efficient anti-wrinkle and firming effects under a multi-channel synergistic effect.

The invention relates to the technical field of functional food, and discloses a food fermentation-based detoxifying, beautifying and antioxidant prescription and a preparation method thereof. The prescription is based on medicinal and edible plants such as black beans, red dates, mulberries, haws, Chinese wolfberry fruits, prepared rehmannia roots, rhizoma polygonati and the like; the purple cabbage powder, the pumpkin powder, the dandelion root powder, the tremella polysaccharide, the quinoa germ powder and the bamboo leaf flavonoid extract are compounded, and the lactobacillus acidophilus and the clostridium butyricum are subjected to synergistic fermentation treatment. The preparation method comprises the steps of raw material pretreatment, mixed saccharification, constant-temperature anaerobic fermentation, after-ripening, sterilization, drying forming and the like. The product is rich in polyphenols, flavonoids, short-chain fatty acids and oligosaccharides, and has remarkable functions of resisting oxidation, clearing bowels, expelling toxins, beautifying, protecting skin and regulating immunity. The optimal fermentation time is 120 hours, compared with a traditional fermentation period, the method has better polyphenol release efficiency and antioxidant activity, the process is mild, the method is suitable for preparing liquid drinks, powder or freeze-dried oral granules, the safety is high, and industrial popularization is easy.