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157 results about "Lactobacillus acidophilus" patented technology

Lactobacillus acidophilus (New Latin 'acid-loving milk-bacillus') is a species of gram positive bacteria in the genus Lactobacillus. L. acidophilus is a homofermentative, microaerophilic species, fermenting sugars into lactic acid, and grows readily at rather low pH values (below pH 5.0) and has an optimum growth temperature of around 37 °C (99 °F). L. acidophilus occurs naturally in the human and animal gastrointestinal tract and mouth. Some strains of L. acidophilus may be considered to have probiotic characteristics. These strains are commercially used in many dairy products, sometimes together with Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus in the production of acidophilus-type yogurt, or acidophiline. Its genome has been sequenced.

Stachyose composition for promoting micro-ecological regulation of lactobacillus and application of stachyose composition

InactiveCN121287726ACosmetic preparationsAntibacterial agentsBiotechnologyBacterial vaginitis
The invention relates to the field of biotechnology and female health care, in particular to a stachyose composition for promoting micro-ecological regulation of lactobacillus and application of the stachyose composition, and the composition comprises stachyose and pharmaceutically acceptable auxiliary materials. The stachyose is used as prebiotics to selectively promote proliferation and colonization of the lactobacillus crispatus, the combination of 1%-5% of the stachyose and 0.1%-0.5% of the lactic acid can promote proliferation of the lactobacillus crispatus, the lactobacillus crispatus is one or more of the lactobacillus crispatus, the lactobacillus plantarum and the lactobacillus acidophilus, and the combination of 1%-5% of the stachyose and 0.1%-0.5% of the lactic acid can inhibit gardnerella and candida albicans. The stachyose composition disclosed by the invention is in the form of slow-release gel and bath foam; the composition can be used for treating or preventing bacterial vaginitis, colpitis mycotica and related symptoms, has the advantages of no antibiotics, no drug resistance, high safety and the like, and is suitable for the fields of vagina local nursing and micro-ecological regulation.
Owner:FOHOW HEALTH PROD CO LTD

PCR primer combination for detecting mixed microorganisms in food fermentation process and detection method thereof

The invention belongs to the technical field of microbiological detection, and discloses a PCR primer combination for detecting mixed microorganisms in a food fermentation process and a detection method thereof. The primer combination comprises a primer pair used for detecting pediococcus pentosaceus, a primer pair used for detecting plant lactobacillus, a primer pair used for detecting lactobacillus mucus fermentation, a primer pair used for detecting bacillus amyloliquefaciens and a primer pair used for detecting lactobacillus acidophilus. The primer pair is at least one of a primer pair for detecting lactobacillus helveticus and a primer pair for detecting acetobacter pasteurianus. The primer combination or the kit containing the primer combination can realize species level specific detection of microorganisms, and can be used for qualitatively / quantitatively detecting food and key functional microorganisms in the food fermentation process, so that the dynamic change of a target flora in the fermentation process is quickly and accurately monitored.
Owner:TIANJIN UNIV OF SCI & TECH

Traditional Chinese medicine composition for intervening in non-alcoholic fatty liver and preparation method thereof

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for intervening in non-alcoholic fatty liver and a preparation method thereof. The preparation method comprises the following steps: (1) weighing the following raw materials: hawthorn, salvia miltiorrhiza, rhizoma alismatis, radix puerariae, astragalus membranaceus, semen cassiae and poria cocos, and respectively crushing; (2) mixing radix astragali, semen cassiae and poria cocos, and performing water extraction to obtain concentrated paste; (3) preparing a fermentation substrate; (4) simultaneously inoculating lactobacillus rhamnosus and lactobacillus acidophilus into the fermentation substrate, and carrying out first-stage anaerobic fermentation; (5) continuously inoculating lactobacillus paracasei and streptococcus thermophilus into the fermentation liquid, and carrying out second-stage anaerobic fermentation; and (6) carrying out vacuum concentration, freeze drying and crushing on the traditional Chinese medicine fermentation liquor to obtain the traditional Chinese medicine fermentation composition for intervening in the non-alcoholic fatty liver disease. The traditional Chinese medicine composition is prepared through specific raw material compatibility and a specific fermentation mode, and a new path is provided for application of traditional Chinese medicine in the field of fatty liver treatment.
Owner:BEIJING GUOHUA XINYE TRADITIONAL CHINESE MEDICINE RES INST CO LTD

An Anti-inflammatory lactobacillus acidophilus composition for regulating immune responses

PCT designated stageWO2026126192A2BiotechnologyProbiotic bacterium
The present invention discloses an anti-inflammatory Lactobacillus acidophilus composition for regulating immune responses, belonging to the fields of microbial technology and biomedicine. The composition comprises live lyophilized powders of Lactobacillus acidophilus, Lactobacillus plantarum, and Bifidobacterium longum, together with homologous postbiotic lyophilized powders of the same strains. By combining functionally complementary probiotics with their homologous postbiotics, a full-chain anti-inflammatory system is constructed, covering immune regulation, inflammation suppression, and intestinal barrier repair. The live bacteria enable long-term colonization and microecological regulation, while the postbiotics act rapidly, producing a synergistic effect. The composition is prepared solely from strain-derived fermentation products without exogenous additives, ensuring safety and purity, and provides a stable and efficient solution for inflammation relief and immune function optimization.
Owner:JABAR YASSINE

Lactobacillus acidophilus FMM01 with effects of improving contractility of pelvic floor muscles and repairing mucous membranes and application of lactobacillus acidophilus FMM01

The invention discloses a lactobacillus acidophilus FMM01 with the effects of improving the contractility of pelvic floor muscles and repairing mucous membranes and application of the lactobacillus acidophilus FMM01, the lactobacillus acidophilus FMM01 is preserved in the China Center for Type Culture Collection, the preservation date is January 9, 2024, and the preservation number is CCTCC NO: M2024052. The lactobacillus acidophilus FMM01 has the advantages of self-adaption, high acid resistance, strong mucous membrane adhesiveness and no irritation to vaginal mucosa. The lyophilized powder is high in activity and excellent in stability; experimental results show that the lactobacillus acidophilus FMM01 can effectively inhibit bacteria, and especially can effectively inhibit enterobacter cloacae, vibrio parahaemolyticus and / or candida albicans. Besides, the lactobacillus acidophilus FMM01 can improve vaginal relaxation, improve pelvic floor muscle contractility and / or recover vaginal mucosa functions, can promote recovery of healthy florae after mixed vaginitis antibiotic / hormone treatment, improves the treatment effect of mixed vaginitis, and remarkably reduces the recurrence rate of mixed vaginitis.
Owner:JIANGSU KERONG BIOPHARMACEUTICAL CO LTD

A composite probiotic agent and application thereof in preparation of fermented soy milk

This invention belongs to the field of food fermentation technology, and specifically relates to a compound probiotic agent and its application in the preparation of fermented soy milk. This invention provides a compound probiotic agent composed of *Lactobacillus fermentum* NCPS LF01, *Pediococcus pentosaceus* NCPS PPE01, and *Lactobacillus acidophilus* NCPS LA01 in a volume ratio of 1-2:1:1, and applies this compound probiotic agent to the preparation of soy products, especially fermented soy milk. The beneficial effects of this invention are that fermented soy milk prepared using this compound probiotic agent has a rich flavor, and the total flavonoid and total phenolic content, as well as the in vitro DPPH free radical scavenging rate, are significantly superior to those of ordinary commercially available strains or other strains. In summary, this compound probiotic agent can effectively improve the retention level of active ingredients and antioxidant capacity of fermented soy milk, and has outstanding application value.
Owner:SHANDONG ACADEMY OF AGRICULTURAL SCIENCES +1

Chewable tablet with compound addition of probiotic fermentation and bacterial powder and preparation method of chewable tablet

The invention provides a probiotic fermentation and bacterial powder compound addition chewable tablet and a preparation method thereof, and belongs to the technical field of microorganisms, the preparation method comprises the following steps: respectively adding water into apple peel, cerasus humilis fruits and aronia melanocarpa fruits, pulping, and mixing in proportion to obtain mixed fruit pulp; a mixed bacterium solution of lactobacillus plantarum LNJ-HQ-01 and lactobacillus fermentum BNCC194390 is added into the mixed fruit pulp, and fermentation is performed; freeze-drying and grinding the fermented fruit pulp to obtain freeze-dried fruit powder; the preparation method comprises the following steps: respectively activating lactobacillus plantarum LNJ-HQ-01, lactobacillus acidophilus BNCC186447 and lactobacillus rhamnosus ATCC7469, performing enlarged culture, taking bacterial sludge, uniformly mixing the bacterial sludge with a freeze-drying protective additive, and performing freeze-drying to obtain freeze-dried bacterial powder; and uniformly mixing the fruit powder, the freeze-dried bacterial powder and the medicinal auxiliary materials, and tabletting to obtain the probiotic chewable tablets. The probiotic chewable tablet is high in dietary fiber content, effective calcium content and total phenol content, high in oxidation resistance and suitable for calcium supplement of special groups such as diabetics and the like.
Owner:LIAONING ACAD OF AGRI SCI

Novel lactobacillus acidophilus strain and use thereof

The present invention relates to a novel Lactobacillus acidophilus strain. Also, the present invention relates to uses of the Lactobacillus acidophilus strain for antibacterial activity, antioxidation, the suppression of periodontal tissue damage or degradation, and anti-inflammation. Also, the present invention relates to a composition comprising the Lactobacillus acidophilus strain. The Lactobacillus acidophilus strain of the present invention can exhibit antibacterial activity against oral harmful bacteria that cause oral diseases, suppress the production of reactive oxygen species (ROS), inhibit the expression or activity of matrix metalloproteinase-3 (MMP-3) that causes periodontal tissue damage or degradation, and inhibit the expression or activity of inflammatory cytokines IL-6 and IL-8. Therefore, the strain and the composition comprising same, of the present invention, can be effectively used for antibacterial activity, antioxidation, the suppression of periodontal tissue damage or degradation, and anti-inflammation, and can also be used for treating, ameliorating or preventing oral diseases.
Owner:GENOME & CO INC

Combination of lactobacillus rhamnosus LRa05, lactobacillus acidophilus La88 and lactobacillus plantarum Lp90 and application of combination in regulation of vaginal mucosal barrier protein

The invention relates to the field of prevention and treatment of vaginitis, in particular to a composition of lactobacillus rhamnosus LRa05, lactobacillus acidophilus La88 and lactobacillus plantarum Lp90 and application of the composition to regulation of vaginal mucosa barrier protein. The lactobacillus rhamnosus LRa05 is a lactobacillus rhamnosus LRa05 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) NO.24377, and the lactobacillus rhamnosus LRa05 is a lactobacillus rhamnosus LRa05 with the preservation number of CGMCC NO.24377. The lactobacillus acidophilus La88 is the lactobacillus acidophilus La88 of which the preservation number is CGMCC (China General Microbiological Culture Collection Center) NO.24109, and the lactobacillus acidophilus La88 is a lactobacillus acidophilus La88 of which the preservation number is CGMCC NO.24109. The lactobacillus plantarum Lp90 is the lactobacillus plantarum Lp90 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) NO.10453, and the lactobacillus plantarum Lp90 has the preservation number of CGMCC NO.10453. The lactobacillus rhamnosus LRa05, the lactobacillus acidophilus La88, the lactobacillus plantarum Lp90 and the combination thereof disclosed by the invention can regulate the expression of the vagina mucosal barrier protein.
Owner:WUHAN WEIKANG PROBIOTICS RES INST CO LTD +1

Selenium-rich rice mineral source soil conditioner and preparation method thereof

The invention discloses a selenium-rich rice mineral source soil conditioner and a preparation method thereof, and belongs to the technical field of soil conditioning materials. The conditioner comprises the following raw materials in parts by weight: 30-70 parts of biological activated yellow phosphorus slag, 1-1.5 parts of soluble selenium, 23-62 parts of an activating agent and 3-10 parts of a modifying agent. The method is characterized in that the biological activated yellow phosphorus slag is prepared by sequentially carrying out thermal activation and acid activation on yellow phosphorus slag and then carrying out solid-state fermentation by utilizing a compound microbial agent consisting of paenibacillus mucilaginosus, lactobacillus acidophilus and P.megatherium. Through unique biological activation modification, the industrial problems that a mineral source conditioner is low in granulation rate and slow in particle hardening and disintegration are solved in a synergistic mode, acid soil can be effectively improved, absorption and enrichment of rice on selenium are remarkably promoted, and high-added-value resource utilization of the yellow phosphorus slag is achieved.
Owner:CHENGDU WINTRUE HLDG CO LTD

A low glycemic index blueberry extract and its preparation method

PendingCN122296472ABiotechnologyBlueberry extract
This invention provides a low glycemic index blueberry extract and its preparation method, belonging to the field of beverage processing technology. The preparation method includes the following steps: blueberries are pulped, then fermented using a compound strain of Lactobacillus acidophilus, Lactobacillus plantarum, and Bifidobacterium, filtered through a membrane filtration device to obtain a blueberry fermentation broth; blueberries are crushed, the pH of an ethanol solution is adjusted to 2-3 with citric acid, followed by ultrasonic extraction, centrifugation to collect the supernatant, and then vacuum distillation of the supernatant to obtain anthocyanin extract concentrate; the anthocyanin extract concentrate is freeze-dried to obtain anthocyanin extract dried product; the anthocyanin extract dried product and blueberry fermentation broth are mixed evenly at a mass-volume ratio of (0.2-0.3) g:1L, then maltitol is added to adjust acidity and sweetness, homogenized, filtered, and sterilized to obtain the blueberry extract. By using compound probiotic fermentation to reduce sugar content and combining it with alcohol extraction to enhance anthocyanins and improve efficacy, the resulting product has anthocyanin content ≥400 mg / L and a low GI.
Owner:GUIZHOU INST OF BIOLOGY

Flavored salad dressing based on modified rice bran fibers and preparation method thereof

The invention relates to the technical field of food processing, and discloses a flavor salad dressing based on modified rice bran fibers and a preparation method thereof.The preparation method comprises the steps that rice bran fiber powder is subjected to enzymolysis and high-pressure homogenization modification, and modified rice bran fiber dispersion liquid is obtained; preparing a fermentation substrate by using the modified rice bran fiber, activating lactobacillus acidophilus and lactobacillus plantarum, inoculating the lactobacillus acidophilus and the lactobacillus plantarum into the fermentation substrate, and fermenting to obtain a fermented rice bran fiber base material; the modified rice bran fiber dispersion liquid, the fermented rice bran fiber base material and other conventional components are used for preparing the flavored salad dressing. The flavored salad dressing is fresh and cool in taste and low in calorie, contains lactic acid, acetic acid and other organic acids and high-content water-soluble dietary fibers (prebiotics), is mellow in flavor, and can effectively promote intestinal health.
Owner:CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Zero sucrose ambient yogurt and a method for preparing the same

The application relates to the field of food, in particular to zero-cane normal-temperature yoghourt and a preparation method thereof. The zero-cane normal-temperature yoghourt comprises the following raw materials in parts by weight: raw cow milk or concentrated milk 80-90 parts, protein powder 0.4-3 parts, cheese 0.3-2 parts, sweetening agent 0.01-15 parts, stabilizer 0.1-5 parts and bacterial strain 50-200 U, the bacterial strain is composed of lactobacillus bulgaricus, streptococcus thermophilus, lactobacillus acidophilus and lactobacillus bifidus, wherein the sum of lactobacillus bulgaricus and streptococcus thermophilus: the sum of lactobacillus acidophilus and lactobacillus bifidus = 9:1-8:2. The application adopts raw cow milk or concentrated milk, protein powder and cheese to form a basic system in a specific proportion, and is fermented by specific bacterial strains, so that the zero-cane yoghourt can reach a fermentation end point within 8 hours, and the product has a good taste.
Owner:INNER MONGOLIA MENGNIU DAIRY IND (GROUP) CO LTD

Use of b. longum exopolysaccharide or co-incubation extract with probiotic for improving inflammation

The application discloses application of Bifidobacterium longum exopolysaccharide or a co-incubation extractive solution of the Bifidobacterium longum exopolysaccharide and probiotics in improving inflammation. The application finds that the Bifidobacterium longum exopolysaccharide and the co-incubation extractive solution of the Bifidobacterium longum exopolysaccharide and Lactobacillus acidophilus can inhibit LPS-induced TLR4 / NfkB (P65) signal path activation, inhibit the polarization of macrophages from M0 to M1, thereby inhibiting inflammatory reactions, and the inhibiting effect of the co-incubation extractive solution of the Bifidobacterium longum exopolysaccharide and Lactobacillus acidophilus is more obvious. Therefore, the Bifidobacterium longum exopolysaccharide and the co-incubation extractive solution of the Bifidobacterium longum exopolysaccharide and Lactobacillus acidophilus can be used for preparing drugs for inhibiting inflammatory reactions, and are helpful to the treatment of immune and chronic inflammatory diseases and the development of related drugs.
Owner:SUN YAT SEN UNIV

Private care wet tissue containing antibacterial composition and preparation method of private care wet tissue

The invention discloses a private care wet tissue containing a bacteriostatic composition, the private care wet tissue comprises a composite non-woven fabric base material and an impregnation liquid, the impregnation liquid comprises the bacteriostatic composition, a soothing anti-inflammatory agent, a moisturizing repairing agent, an odor removal regulator, a cosolvent and a stabilizer; the preparation method comprises the following steps: adding purified water, a citric acid-sodium citrate buffer agent and EDTA (Ethylene Diamine Tetraacetic Acid) disodium into a vacuum stirring tank, then adding glycerol, micromolecular sodium hyaluronate and ceramide 3, and then adding L-lactic acid and a lactobacillus acidophilus fermentation product; sequentially adding nisin, cranberry extract, polyhexamethylene biguanide hydrochloride and beta-cyclodextrin inclusion tea tree essential oil, and finally adding dipotassium glycyrrhizinate, allantoin and citrus extract. Different from the prior art that private care wet tissues only have a single antibacterial function and neglect flora balance, peculiar smell is covered by depending on essence, the base material and the steeping liquor are designed at the same time, and the functions of bacteriostasis and antibiosis, gentle private care, odor removal and itching relieving, inflammation prevention and swelling prevention, flora balance maintenance and the like are achieved.
Owner:MIAOWANG PHARMACEUTICAL (GUANGZHOU) CO LTD

PRODUCTION PROCESS OF POWDERED SYNBIOTIC FROM TURMERIC STARCH (CURCUMA LONGA L.)

PendingVN8087UBiotechnologyBanana powder
The useful solution refers to the process of producing a powdered synbiotic preparation from turmeric starch (Curcuma longa L.). The process includes the following steps: a) preparing the turmeric starch powder, loosening, lightly grinding, sieving, and mildly heat-treating at a temperature of 65°C to 75°C for 20 to 40 minutes to obtain pre-treated turmeric starch; b) mixing the pre-treated turmeric starch with the prebiotic, which is green banana powder, and other ingredients including milk powder, glutinous rice flour, Ganoderma lucidum mushroom powder, and dried cane sugar to create a dry substrate mixture; c) adding honey and treated clean water to adjust the moisture content of the substrate mixture to 45% to 55% by weight to create a semi-solid substrate; d) inoculating with a probiotic mixture consisting of Lactiplantibacillus plantarum microorganisms.Lactobacillus acidophilus and Bacillus subtilis with a total inoculation density of 10⁷ to 10⁹ CFU / g of semi-solid substrate; e) semi-solid fermentation at a temperature of 35°C to 40°C for 24 to 48 hours; f) drying the fermented substrate at a temperature not exceeding 50°C until the moisture content is no more than 12% by weight; g) loosening, grinding, and / or sieving the product after drying, then packaging in airtight containers. The resulting preparation is in powder form, containing turmeric starch, green banana powder acting as prebiotics, and live probiotics.
Owner:CÔNG TY TNHH VINH LƯƠNG BIOGREEN

Nitrogen-free smoked ginseng sausage and preparation method thereof

The invention discloses a nitrate-free smoked ginseng sausage and a preparation method thereof, and belongs to the technical field of meat product processing. The method comprises the following steps: adding different addition amounts of ginseng powder into a nitrate-free smoked sausage to prepare the nitrate-free smoked ginseng sausage, mincing pork serving as a main raw material, adding water, plasma activated water, beet root powder, celery powder, ginseng powder and nisin, and uniformly stirring to prepare the nitrate-free smoked ginseng sausage. The preparation method comprises the following steps: uniformly stirring other ingredients including table salt, white granulated sugar, monosodium glutamate, potato starch, soybean protein isolate, pepper powder and ginger powder, pickling, filling, cooking, drying to be mature, cooling, and packaging in vacuum to obtain the nitrate-free ginseng smoked sausage. According to the method, the flavor quality and functional characteristics of the nitrate-free smoked sausage are optimized, the defects of a single nitrate-free smoked process in flavor level and nutritional added value are overcome, and the flavor and texture of the sausage are remarkably improved.
Owner:JILIN UNIVERSITY

Lactobacillus acidophilus with high activity and high yield of organic selenium

This invention discloses a highly active Lactobacillus acidophilus strain that produces high levels of organic selenium, belonging to the field of microbial technology. The Lactobacillus acidophilus CCFM1304 obtained by screening in this invention exhibits high activity and can efficiently enrich inorganic selenium, converting it into organic selenium for better absorption and utilization by the body. Specifically: (1) Lactobacillus acidophilus CCFM1304 can efficiently enrich inorganic selenium, converting it into organic selenium with an organic selenium content of 95.3%, and the content of selenocysteine ​​in the organic selenium is as high as 67.8%; (2) Lactobacillus acidophilus CCFM1304 has high activity, and the viable count of the freeze-dried bacterial powder can reach 6.5 × 10⁻⁶. 11 CFU / g. The highly active Lactobacillus CCFM1304 of this invention can efficiently enrich inorganic selenium, and has great application prospects in the field of inorganic selenium biotransformation.
Owner:JIANGNAN UNIV

Lactobacillus acidophilus goldgut-la100 having functions of lipid lowering, blood glucose lowering and weight loss and application thereof

The present invention relates to the technical field of microorganisms, in particular to a Lactobacillus acidophilus GOLDGUT-LA100 having functions of lipid lowering, blood glucose lowering and weight loss and application thereof. The Lactobacillus acidophilus GOLDGUT-LA100 provided by the present invention is preserved in China General Microbiological Culture Collection Center, with the preservation number of CGMCC No. 28398. The strain has strong acid resistance, can adapt to the digestive tract environment, and has high bile salt hydrolase activity. At the same time, in animal experiments, the strain significantly reduces blood glucose and serum cholesterol levels, reduces liver fat deposition, reduces adipose tissue inflammation, effectively reduces the weight, and has broad application prospects in the development of products for improving obesity, lowering lipid and lowering blood glucose.
Owner:SHENZHEN PORSHEALTH BIOENGINEERING CO LTD

Anti-inflammatory and acne-removing salix angustifolia emulsion and mask preparation method thereof

The invention discloses a salix angustifolia anti-inflammatory and acne-removing emulsion and a mask preparation method thereof, and relates to the technical field of skin care product processing. The preparation method of the epilobium angustifolium extract comprises the following steps: taking fresh epilobium angustifolium, drying and pulping to obtain pulp; adding cellulase for enzymolysis to obtain enzymatic hydrolysate, wherein the mass ratio of the cellulase to the pulp is 1: (10-20); a lactobacillus acidophilus liquid is added into the enzymatic hydrolysate, ultrasonic treatment is performed after uniform mixing, and the mass ratio of the lactobacillus acidophilus liquid to the enzymatic hydrolysate is 1: (20-50); putting the enzymatic hydrolysate subjected to ultrasonic treatment into a fermentation tank for fermentation to obtain fermentation liquor, centrifuging the fermentation liquor, and collecting supernate; and adsorbing the supernate through a perforated resin column, eluting, filtering and freeze-drying to obtain the willow flower extract. Through the synergistic effect of the willow flower extract, various natural oils and fats, the extracting solution and the auxiliary materials, inflammation is effectively inhibited, and the acne skin problem is solved. Firstly, through enzymolysis and fermentation processes, effective components in the willow flower extract are reserved, and the anti-inflammatory effect is enhanced;
Owner:QINGHAI UNIV FOR NATITIES

Lactobacillus acidophilus for treating chronic cerebral ischemia

The invention discloses a strain of lactobacillus acidophilus for treating chronic cerebral ischemia, which is preserved in the China Center for Type Culture Collection (CCTCC) and has the preservation number of CCTCC NO: M 20251505. Animal experiments show that the strain can reduce the death rate of chronic cerebral ischemia model mice and improve neurological impairment, motion coordination and spatial learning and memory ability of the chronic cerebral ischemia model mice. Mechanism research shows that the strain can increase histone acetylation and BDNF secretion by inhibiting the activity of astrocyte HDAC1, and meanwhile, can inhibit an NF-kappa B signal channel and reduce inflammatory factor release by activating a microglial cell GPR120 receptor, so that a neuroprotective effect is achieved through an'intestine-brain axis'. The invention provides a new candidate strain for the development of microbial preparations for preventing and / or treating chronic cerebral ischemia and related cognitive impairment.
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH

Symbiotic fermentation method for Tibetan kefir

The invention relates to the technical field of microbial fermentation, enzyme engineering and food processing, in particular to a symbiotic fermentation method for Tibetan kefir. The invention discloses a symbiotic fermentation method of Tibetan kefir, which comprises the following steps: firstly, taking honeysuckle enzymatic hydrolysate, fermented whey and the like as raw materials, and adding low-acyl gellan gum and the like to prepare a compound substrate; the Tibetan kefir bacterial sludge is subjected to resuscitation and expanding culture to obtain a secondary seed solution, the secondary seed solution is mixed with the compound matrix and then subjected to micro-aerobic fermentation twice, and lactobacillus acidophilus is added for enhanced fermentation; after the fermentation liquor is distilled and centrifuged, sodium alginate and trimethyl chitosan are cross-linked to prepare a multi-layer microcapsule, and then sterile grape juice is added for blending to obtain a finished product. According to the process, fermentation core parameters and enzymolysis and cross-linking key steps are optimized, the product has both nutrition and flavor, and technical support is provided for industrial production of non-alcoholic fermented beverages.
Owner:广州博士派生物科技有限公司

Composition with effects of reducing weight and reducing blood fat and application thereof

The invention discloses a composition with effects of reducing weight and reducing blood fat and application of the composition, and belongs to the technical field of biology. The composition comprises 30%-80% of a probiotic compound and 20%-70% of a raw material containing glycerol glycolipid, the probiotic compound takes lactobacillus reuteri as an essential component, and further comprises any one or more of bifidobacterium, lactobacillus fermentum, lactobacillus fermentum, lactobacillus acidophilus, lactobacillus casei, lactobacillus rhamnosus, lactobacillus brevis and bacillus coagulans. According to the invention, the specific probiotic compound is screened and compounded with the raw materials rich in glyceroglycolipid, and the synergistic effect of the probiotic compound and the raw materials is utilized to improve the weight-reducing and blood fat-reducing effects. According to the composition developed by the invention, the problem of resource waste caused by the fact that raw materials such as nannochloropsis oculata oil rich in glyceroglycolipid cannot be effectively absorbed in the prior art is solved, the nutritional effect of the composition is improved, and the composition has a wide application prospect in the fields of food, health care products and medicines.
Owner:OCEAN UNIV OF CHINA +2

Fermented product of fruit and vegetable waste and corn stalks and application thereof

The application belongs to the technical field of microbial fermentation, and particularly relates to a fermentation product of fruit and vegetable wastes and corn stalks and application thereof. The fermentation product is obtained by inoculating Aspergillus oryzae SLY-M-15 fermentation product and Saccharomyces cerevisiae into a first mixture containing crushed and air-dried corn stalks and fruit and vegetable wastes, performing aerobic fermentation, adding a second mixture containing crushed and air-dried corn stalks and fruit and vegetable wastes and corn cob, performing secondary aerobic fermentation, inoculating Lactobacillus casei, Lactobacillus acidophilus and Lactobacillus fermentum, and performing anaerobic fermentation. The obtained fermentation product is applied to animal feed, can improve the average daily weight gain of mutton sheep, reduce the feed conversion ratio, improve the tenderness and cooked meat rate of mutton, and increase the content of n-3 polyunsaturated fatty acids.
Owner:山东泰山生力源集团股份有限公司

A compound microbial inoculant and fermentation method for preparing pickled Chinese cabbage by soybean water fermentation

The application provides a compound microbial inoculum for preparing pickled Chinese cabbage through fermentation of bean water and a fermentation method, and belongs to the technical field of fermented food technology.The compound microbial inoculum for preparing pickled Chinese cabbage through fermentation of bean water comprises the following bacterial species in percentage by mass: 40-60% of Lactobacillus plantarum, 20-35% of Lactobacillus acidophilus, 10-25% of Saccharomyces cerevisiae and 5-15% of Bacillus acidophilus.The pre-processed bean water is used as a fermentation substrate, and the compound microbial inoculum is inoculated to prepare pickled Chinese cabbage through fermentation, so that the fermentation period is shortened, the fermentation quality of the pickled Chinese cabbage is improved, the safety of the pickled Chinese cabbage is ensured, the pickled Chinese cabbage is endowed with special bean aroma, and the resource utilization of the bean water is realized.
Owner:LIAONING ACAD OF AGRI SCI

A probiotic composition and a process for the production of probiotic fermented bread crumbs

The application discloses a probiotic composition and a production process of a probiotic fermented bread crumb, and belongs to the technical field of bread crumb processing. The probiotic composition is a microcapsule structure containing malt dextrin, arabic gum and heat-denatured whey protein isolate as wall materials, and lactobacillus acidophilus and lactobacillus rhamnosus as core materials. The structure can ensure that a small amount of live bacteria and metabolic products are slowly released through the micropores of the wall materials in a normal temperature fermentation environment, so that the free lactic acid bacteria are prevented from rapidly proliferating, excessively producing acid and competing with yeast for carbon and nitrogen sources in the initial stage of fermentation. The probiotic composition can provide nutrition for the yeast in the fermentation process, promote cell division and metabolic activity of the yeast, and the polydextrose, inulin and arabic gum in the microcapsule wall materials are hydrophilic colloids, which can form a uniform hydration network in the dough.
Owner:ANHUI XINRUNTAI FOOD TECHNOLOGY CO LTD

Preservation method of day lily

The invention relates to the technical field of hemerocallis citrina baroni preservation, in particular to a hemerocallis citrina baroni preservation method which comprises the following steps: S1, keeping 0.5-1.5 cm moss stems when the hemerocallis citrina baroni is picked; s2, quickly inserting and pulling stems of the day lily into the high-temperature liquid-state fresh-keeping gel, and forming fresh-keeping gel drops at the stems of the day lily; the fresh-keeping gel is prepared from the following components: 4 to 5 parts of sodium carboxymethyl cellulose, 0.5 to 1 part of gelatin, 0.5 to 1 part of melatonin, 1.5 to 2 parts of glycerol, 7 to 9 parts of lactobacillus acidophilus metabolite and 100 parts of water; and S3, tidily arranging the day-lily buds in a fresh-keeping box or a breathable package for storage. The day lily storage method is low in cost, safe, environment-friendly, long in storage time and excellent in storage quality, and a special picking mode is combined with the combined action of active ingredients in fresh-keeping gel, so that the day lily buds are completely not in contact with the fresh-keeping agent, but the long-acting and efficient fresh-keeping effect can be achieved.
Owner:SICHUAN AGRI UNIV

Kidney and liver nourishing compound probiotic cistanche fermented drink and preparation method thereof

This invention discloses a kidney-tonifying and liver-nourishing compound probiotic Cistanche fermented drink and its preparation method, comprising the following steps: mixing and sterilizing Cistanche deserticola, Poria cocos, malt, functional components, and natural selenium-strontium mineral water to obtain a fermentation substrate; activating *Lactobacillus casei*, *Lactobacillus acidophilus*, *Lactobacillus rhamnosus*, and *Lactobacillus plantarum* strains respectively, centrifuging and freeze-drying, and then mixing them to obtain a compound probiotic powder; culturing the compound probiotic powder in MRS medium to obtain a compound probiotic liquid; inoculating the compound probiotic liquid into the fermentation substrate for fermentation, sterilizing, and obtaining the kidney-tonifying and liver-nourishing compound probiotic Cistanche deserticola fermented drink. This invention, through the innovative integrated formulation technology of combining Cistanche deserticola, malt, and Poria cocos as medicinal and edible ingredients, multifunctional factor compounding, and compound probiotic fermentation, prepares a kidney-tonifying probiotic Cistanche deserticola fermented drink with high active ingredients, clear efficacy, and excellent flavor.
Owner:GUANGDONG YUANCHEN PHARM TECH CO LTD

A feline oral care probiotic composition and uses thereof

ActiveCN116200307BBiotechnologyMouth care
The application discloses a cat oral cavity nursing probiotic composition and application thereof, and the probiotic composition comprises animal bifidobacterium and lactic acid bacteria, wherein the lactic acid bacteria is any one or a combination of multiple of salivarius, lactobacillus casei, enterococcus faecalis, lactobacillus rhamnosus, lactobacillus plantarum, lactobacillus acidophilus and lactobacillus reuteri; compared with single probiotic, the probiotic composition has better effect on oral cavity odor removal, can effectively improve cat oral cavity source halitosis, and can also reduce dental plaque formation, relieve gingivitis and dental caries, and can be applied to preparation of a cat oral cavity odor cleaner, and has good application prospect.
Owner:JUNWEIAN (WUHAN) LIFE TECHNOLOGY CO LTD

Czodiac paste capable of reducing prolactin, promoting digestive absorption and assisting in resisting tumors and preparation method of zodiac paste capable of reducing prolactin, promoting digestive absorption and assisting in resisting tumors

The invention belongs to the technical field of traditional Chinese medicine preparations, and discloses a haw traditional Chinese medicine ointment formula capable of reducing prolactin, promoting digestive absorption and assisting in resisting tumors and a preparation method of the haw traditional Chinese medicine ointment formula. The cream formula comprises 12-15% of Chinese dates, 10-15% of fried malt, 8-10% of lalang grass rhizome, 8-10% of chrysanthemum, 7-10% of coix seeds, 7-10% of dandelion, 5-7% of dried tangerine or orange peel, 5-7% of radix polygonati officinalis, 4-6% of hawthorn, 4-5% of Chinese yam, 4-5% of poria cocos, 3-5% of endothelium corneum gigeriae galli, 3-4% of liquorice, 2-3% of platycodon grandiflorum and 2-6% of honey. Wherein the Chinese yam and the poria cocos need to be fermented by lactobacillus acidophilus, and the dried orange peel needs to be subjected to compound enzymolysis by cellulase and pectinase. The traditional Chinese medicine composition has the effects of reducing prolactin, promoting digestion and assisting in resisting tumors. In addition, the traditional Chinese medicine composition has a protection effect on hematopoietic function damage caused by ionizing radiation. The food is suitable for dietary auxiliary conditioning of people in the tumor rehabilitation period, people with hyperprolactinemia and people with weakness of the spleen and the stomach and dyspepsia.
Owner:NANJING JIUHU ANCIENT TRADITIONAL CHINESE MEDICINE RESEARCH INSTITUTE CO LTD