176 results about "Lactobacillus salivarius" patented technology

The invention discloses an intestinal flora marker related to Parkinson's syndrome and application of the intestinal flora marker. The invention discloses an intestinal flora marker, which comprises one or a combination of more of bacteroides faecalis, bacteroides vulgaris, bacteroides thetaotamicrobe, ruminococcus ruminococcus and lactobacillus salivarius, and is characterized in that the intestinal flora marker comprises one or a combination of more of bacteroides faecalis, bacteroides vulgaris, bacteroides thetaotamicrobe, ruminococcus ruminococcus and lactobacillus salivarius, and the intestinal flora marker comprises one or a combination of more of the bacteroides vulgaris, the bacteroides vulgaris, the bacteroides thetaotamicrobe, the ruminococcus ruminococcus and the lactobacillus salivarius. The intestinal flora marker is used as a detection marker to be applied to diagnosis of Parkinson's syndrome patients, and is completely noninvasive and high in accuracy.

The invention relates to an oral mucosa repairing medicine and a preparation method thereof, and belongs to the technical field of medicines, the medicine comprises barnacle peptide, salivary lactobacillus, resveratrol, a biphasic adhesion matrix, hydroxyapatite, vitamin B family and other components. The preparation method comprises the following steps: sequentially carrying out enzymolysis on barnacle gooseneck by pepsin and lumbrukinase to obtain barnacle peptide. The double-phase adhesion matrix comprises a water-phase matrix, an oil-phase matrix and lecithin; the water-phase matrix contains a chondroitin sulfate-chitosan quaternary ammonium salt compound, sodium alginate and other components; the oil-phase matrix comprises sesame oil, beeswax, a polylactic acid-glycolic acid copolymer and the like. According to the invention, barnacle peptide and salivary lactobacillus are prepared by adopting a special method and are matched with resveratrol for use, so that multi-target and multi-path promotion of oral mucosa repair can be realized; the chondroitin sulfate-chitosan quaternary ammonium salt compound is prepared through electrostatic and physical embedding, the chondroitin sulfate-chitosan quaternary ammonium salt compound is matched with other components to prepare the biphasic adhesion matrix, the biocompatibility is good, the adhesion is high, and the action time of a sustained-release drug is well prolonged.

The invention discloses a panax quinquefolius probiotic beverage and a preparation method thereof, and relates to the technical field of functional foods. According to the beverage, the combination of the American ginseng extract and specific probiotics is taken as a core, the survival rate of thalli is increased by adopting a microcapsule embedding technology, and the product performance is optimized by adding a stabilizer and a flavor regulator. The formula comprises 5-15% of a panax quinquefolius extract, 3-8% of compound probiotic freeze-dried powder (lactobacillus plantarum, lactobacillus salivarius and bifidobacterium lactis), 10-25% of inulin, 5-15% of whey protein, 10-30% of a microcapsule wall material (sodium alginate / chitosan or a WPI-KGM compound), and auxiliary materials. According to the preparation method, the active ingredients are efficiently reserved through the processes of gradient extraction, microcapsule embedding, low-temperature drying and the like. The product has the functions of resisting fatigue, regulating intestinal flora and enhancing immunity, the survival rate of probiotics in simulated gastric juice reaches 85% or above, and the shelf life stability is improved by 40%.

The invention discloses combined lactobacillus salivarius CCFM1327 capable of inhibiting foaming of macrophages and relieving periodontitis, and belongs to the technical field of microorganisms. According to the invention, the strain of combined lactobacillus salivarius CCFM1327 is obtained, and the combined lactobacillus salivarius has the effects of inhibiting foaming of macrophages and relieving periodontitis, which are specifically reflected in that the combined lactobacillus salivarius can inhibit foaming of RAW264.7 cells caused by ox-LDL; the growth of porphyromonas gingivalis can be effectively inhibited; the periodontal probing and diagnosing depth of the periodontitis rats can be obviously reduced; the number of pathogenic bacteria in the oral cavity of the periodontitis rat is reduced; the level of an inflammatory factor IL-17A in serum is reduced; alveolar bone loss of rats suffering from periodontitis is reduced; and the number of alveolar bone osteoclasts is reduced.

The invention discloses a porcine epidemic diarrhea virus (PEDV) infection resistant Min pig source lactobacillus salivarius LSM231 and application thereof, and belongs to the technical field of microorganisms. The Min pig source lactobacillus salivarius is named as Ligilbacillus salivarius LSM231 and is preserved in the China Center for Type Culture Collection, the preservation number is CCTCC NO: M 20242330, and the preservation time is October 25, 2024. The Min pig source lactobacillus salivarius has the advantages that the Min pig source lactobacillus salivarius is named as Ligilbacillus salivarius LSM231 and is preserved in the China Center for Type Culture Collection (CCTCC); the screened Min pig source lactobacillus salivarius is symbiotic probiotics in intestinal tracts and is high in safety performance, and experimental results show that the Min pig source lactobacillus salivarius LSM231 has relatively good antibacterial, acid-resistant and cholate-resistant characteristics, has a remarkable PEDV (porcine epidemic diarrhea virus) resisting effect, and can relieve clinical symptoms caused by PEDV infection and promote growth of piglets, so that the Min pig source lactobacillus salivarius LSM231 can be used for preventing and treating the porcine epidemic diarrhea. The compound can replace antibiotics to be used for preparing a micro-ecological preparation for resisting PEDV (porcine epidemic diarrhea virus) infection.

The invention discloses a metagen prepared by combining saliva with lactobacillus and capable of improving expression of host antibacterial peptide and immune globulin and application of the metagen, and belongs to the technical field of microorganisms. The combined lactobacillus salivarius disclosed by the invention has the capability of regulating and controlling host immunity and improving pathogenic bacterium infection resistance of a host oral cavity, can remarkably up-regulate expression of a human oral keratinocyte antibacterial peptide HBD-2 gene and protein in vitro, and can remarkably up-regulate expression of DEFB3 (homolog of human HBD-2) and secretory immune globulin SIgA in a mouse body; the compound can be used for preparing a series of products for enhancing the oral immunity of a host and resisting oral pathogenic bacteria infection, and has a huge application prospect.

The invention provides a mouthwash composition which comprises the following effective components: lactobacillus salivarius, domiphen, a pH regulator, a stabilizer and a preservative, the content of the lactobacillus salivarius is 107-1011 CFU / mL, the concentration of the domiphen is 0.05-0.2 wt%, the pH value of the mouthwash composition is regulated to 6.8-7.2 by the pH regulator, and the balance of water, the mouthwash composition can achieve an improved antibacterial effect in an oral environment, and can achieve a lasting antibacterial effect under the condition of maintaining the balance of oral microbial communities.

The invention discloses a composition for dispelling effects of alcohol and protecting liver and application thereof, and belongs to the technical field of biology. The composition comprises the following components in percentage by mass: 0.5-2% of probiotics, 6-20% of beta-glucan, 10-20% of corn peptide and 50-80% of medicinal and edible substances, and the probiotics are mixed bacterial powder prepared by freeze-drying bacillus coagulans BCN019 and lactobacillus salivarius JYLS-372 and then mixing the bacillus coagulans BCN019 and the lactobacillus salivarius JYLS-372 according to a mass ratio of (0.1-1): 1; the medicinal and edible substance is obtained by mixing a hovenia dulcis thunb extract, a kudzuvine root extract and a turmeric extract in a mass ratio of (0.1-1): (0.1-1): (0.1-1). The composition can relieve headache, dizziness and other uncomfortable symptoms caused by drinking; the contents of ethanol and acetaldehyde in the body can be obviously reduced, and the metabolism of the liver is relieved; meanwhile, by improving the intestinal microecology, gastrointestinal discomfort symptoms caused by excessive drinking can be effectively reduced, and hangover reaction is relieved.

The present application belongs to the field of microbial technology, and specifically discloses the application of Lactobacillus salivarius strain CGMCC No. 23518 in the preparation of antibacterial extracts. The present application inoculates Lactobacillus salivarius strain PC114 (CGMCC No. 23518) in the supernatant after fermentation in TPY medium, and obtains an antibacterial extract that inhibits intestinal pathogens, oral pathogens, epidermal pathogens, environmental pathogens and antibiotic-resistant microorganisms after ammonium sulfate precipitation, desalination and freeze-drying. The molecular weight of the effective ingredient of the antibacterial extract is greater than 3000Da, and it has no inhibitory effect on conventional probiotics. The present application discloses a new process and new use for preparing antibacterial substances by fermentation of Lactobacillus salivarius, and has a potential prospect for producing antibacterial substances.

The invention relates to the technical field of probiotics, in particular to lactobacillus salivarius and application of the lactobacillus salivarius in regulating flora balance of digestive tracts of mutton sheep. The invention provides a lactobacillus salivarius KS1018, and the preservation number of the lactobacillus salivarius KS1018 is CCTCC (China Center for Type Culture Collection) NO: M 2025020. The lactobacillus salivarius KS1018 is a strain which is separated from dolang sheep rumen fluid and has the characteristics of high temperature resistance, acid resistance and cholate resistance, and has the advantages of low immunogenicity and high safety when being applied to mutton sheep. Due to the high-temperature-resistant characteristic, high stability can be kept in the feed mixing and processing process, and the application effect is further improved. The acid-resistant and cholate-resistant characteristics can reduce the influence of the digestive tract on the activity of the feed additive, so that the feed additive effectively plays a role in the digestive tract of the ruminant. The strain is good in palatability after being fed, and can effectively regulate digestive tract flora of ruminants, restore digestive tract flora balance and improve the disease-resistant potential of the ruminants.

The invention discloses combined lactobacillus salivarius CCFM1398 for regulating and controlling bone homeostasis and relieving bone resorption and a metagen of the combined lactobacillus salivarius CCFM1398, and belongs to the technical field of microorganisms. The combined lactobacillus salivarius CCFM1398 provided by the invention is separated from oral dental plaque of healthy teenagers, has the effects of relieving bone resorption and resisting inflammation, and is specifically reflected in that expression of protein level and gene level of MC3T3-E1 cell osteoprotegerin (OPG) is improved in vitro; the bone absorption amount of orthodontic bone absorption rat alveolar bone is reduced, the number of alveolar bone osteoclasts is reduced, and the level of rat serum OPG is improved; the secretion of inflammatory factors TNF-alpha, IL-6 and MPO of the orthodontic bone absorption rat is reduced; and the pathological condition of orthodontic bone absorption rat alveolar bone tissue is improved. Therefore, the combined lactobacillus salivarius has a huge application prospect in products for relieving bone resorption and assisting in inhibiting periodontal tissue inflammation.

The invention provides a feed additive capable of improving immunity of pet cats as well as a preparation method and application of the feed additive, and belongs to the technical field of animal feed additives. The feed additive comprises probiotics and a traditional Chinese medicine extract, the probiotics comprise bifidobacterium animalis, combined lactobacillus salivarius and saccharomyces cerevisiae boulardii, and the traditional Chinese medicine extract comprises astragalus polysaccharide, curcumin and resveratrol. The probiotics directly enhance intestinal immunity through colonization resistance and metabolites, the traditional Chinese medicine components form internal and external dual defense through system immune activation, immunity-flora dual regulation is achieved, the probiotics and the traditional Chinese medicine extract form a symbiotic system of increasing the drug effect through bacteria and protecting the bacteria through drugs, and 1 + 1gt is achieved; and 2, the immunity improving effect is achieved.

The invention relates to combined lactobacillus salivarius LS100 for inhibiting vaginitis pathogenic bacteria and preventing and treating vaginitis and application of the combined lactobacillus salivarius LS100. The combined lactobacillus salivarius LS100 is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC NO.32135. The combined lactobacillus salivarius LS100 has good hydrogen peroxide production capacity and adhesion capacity, and can be used for preparing medicines for preventing and treating vaginitis. The traditional Chinese medicine composition has a relatively strong inhibition effect on main vaginitis pathogenic bacteria, is effective on nutritional pathogenic bacteria, and can also reduce form transformation and biological membrane formation of the pathogenic bacteria and prevent generation of drug resistance; besides, the fermentation product can reduce the content of pathogenic bacteria metabolites, regulate the secretion of cell factors and play a role in relieving inflammation, so that the fermentation product can be used for preparing products for preventing and treating genital tract pathogenic bacteria infection and / or preventing and treating vaginitis.

Disclosed in the present invention is a probiotic. The probiotic comprises Parabacteroides distasonis with the microbial deposit number of CCTCC NO: M20222033, Limosilactobacillus fermentum with the microbial deposit number of CCTCC NO: M2023352, Lactobacillus salivarius with the microbial deposit number of CCTCC NO: M2023348, Enterococcus avium with the microbial deposit number of CCTCC NO: M2023350, and Bifidobacterium bifidum with the microbial deposit number of CCTCC NO: M2023349. The probiotic has good safety, has antioxidant activity, can inhibit pathogenic bacteria, can alleviate colon injury, can inhibit inflammation, and can alleviate diarrhea caused by chemotherapeutic drugs.

The invention provides a combined lactobacillus salivarius strain 8-2 and an application of the combined lactobacillus salivarius strain 8-2. The combined lactobacillus salivarius strain 8-2 is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number of the combined lactobacillus salivarius strain 8-2 is CGMCC NO.30612. The invention further provides a preparation method of the combined lactobacillus salivarius strain 8-2. The lactobacillus salivarius disclosed by the invention has the advantages of good acid resistance, no hemolysis and relatively strong antibacterial ability, can relieve injury caused by salmonella infection, can effectively promote the absorption function of intestinal mucosa, improves the production performance of laying hens, and improves the production efficiency of the laying hens. The strain has the potential of being developed into a laying hen high-quality probiotic preparation with an anti-replacement function and a function of promoting intestinal mucosal injury repair, and can be applied to preparation of laying hen antibiotic substitutes, including application of strain fermentation supernatant in preparation of laying hen antibiotic substitutes.

The invention discloses combined lactobacillus salivarius CCFM1332 with a multi-target regulation effect and application of the combined lactobacillus salivarius CCFM1332 in periodontitis, and belongs to the technical field of microorganisms. The invention discloses a strain of combined lactobacillus salivarius CCFM1332, and the combined lactobacillus salivarius not only has a vaginal immune regulation effect, but also has an effect of relieving periodontitis, which is specifically embodied in that: the combined lactobacillus salivarius can promote vaginal epithelial cells VK2 / E6E7 to secrete antibacterial peptides; the periodontal probing and diagnosing depth of the periodontitis rats can be reduced; the number of pathogenic bacteria in the oral cavity of the periodontitis rat is reduced; the levels of inflammatory factors IL-1beta, IL-6 and IL-17A in serum are reduced; alveolar bone loss of rats suffering from periodontitis is reduced, and the alveolar bone absorption condition of the rats is effectively relieved.

The invention discloses a combined lactobacillus salivarius CCFM1397 for improving osteoblast activity and relieving bone resorption and periodontal tissue damage and a metagen thereof, and belongs to the technical field of microorganisms. The lactobacillus salivarius combination CCFM1397 provided by the invention is separated from oral dental plaque of healthy teenagers, has the effects of relieving bone resorption and resisting inflammation, and is specifically reflected in that: the expression of MC3T3-E1 cell osteoprotegerin (OPG) protein and gene level is improved in vitro; the bone absorption amount of orthodontic bone absorption rat alveolar bone is reduced, the number of alveolar bone osteoclasts is reduced, and the level of rat serum OPG is improved; the secretion of inflammatory factors IL-1beta, IL-6 and TNF-alpha and myeloperoxidase MPO of the orthodontic bone absorption rats is reduced; and the pathological condition of orthodontic bone absorption rat alveolar bone tissue is improved. Therefore, the combined lactobacillus salivarius has a huge application prospect in products for relieving bone resorption and assisting in inhibiting periodontal tissue inflammation.

The invention belongs to the technical field of biomedical treatment and biological fermentation, discloses a metagen composition for effectively inhibiting oral dental caries and application thereof, and aims to solve the problems of great side effect, weak effect and unknown mechanism of the existing dental caries prevention and treatment means. The composition is prepared by mixing a metagen 1 which is prepared by fermenting lactobacillus salivarius Postbio-YY with a metagen 2 which is prepared by fermenting lactococcus lactis Postbio-F3 and lactobacillus paracasei Postbio-P6 step by step. In the preparation process, the active ingredients are reserved by accurately controlling the fermentation pH, time and pasteurization parameters. The composition can be prepared into multiple dosage forms such as toothpaste and the like, can remarkably inhibit the growth of streptococcus mutans and destroy the thallus structure, inhibits biofilm and exopolysaccharide synthesis by down-regulating fimI, wcaJ and wcae genes, is safe and free of side effects, and provides an efficient scheme for decayed tooth prevention and treatment.

The invention discloses an anti-allergic probiotic composition as well as a preparation method and application thereof. The probiotic composition is prepared from the following raw materials in parts by weight: 10 to 50 parts of lactobacillus reuteri PG-LRL116, 10 to 50 parts of lactobacillus acidophilus, 10 to 50 parts of lactobacillus rhamnosus, 10 to 30 parts of lactobacillus gasseri, 10 to 30 parts of lactobacillus salivarius, 5 to 15 parts of cordyceps militaris aqueous extract, 5 to 15 parts of rosemary aqueous extract and 5 to 15 parts of dendrobium huoshanense yeast. The preparation method of the probiotic composition comprises the following steps: preparing the cordyceps militaris aqueous extract, the rosemary aqueous extract and the dendrobium huoshanense yeast; the preparation method comprises the following steps: uniformly mixing lactobacillus reuteri PG-LRL116, lactobacillus acidophilus, lactobacillus rhamnosus, lactobacillus gasseri, lactobacillus salivarius, a cordyceps militaris aqueous extract, a rosemary aqueous extract and a dendrobium huoshanense fermentation product, so as to prepare the anti-allergic probiotic composition. The probiotic composition disclosed by the invention can be used for effectively inhibiting the occurrence of food sensitization reaction.

The invention belongs to the technical field of microorganisms, and particularly relates to combined lactobacillus salivarius and application thereof in female genital tract health. The preservation number of the strain is CCTCC NO: M20231719, and the strain has good bacteriostatic ability and dendritic cell (DC) maturation / activation stimulation ability, has no potential safety problem, can regulate vaginal micro-ecological balance, prevent infection caused by exogenous bacteria, effectively improve tumor immunosuppression microenvironment, and has good application prospects. And the method has very important significance on prevention / treatment of vaginal dysbacteriosis patients, gynecological tumors and precancerous lesions thereof.

The invention discloses a high-protein vinasse fermented feed which is prepared by taking 60-80% of vinasse and 20-40% of an auxiliary material as raw materials, inoculating a bacillus licheniformis bacterial liquid, a candida utilis bacterial liquid, a lactococcus lactis bacterial liquid and a lactobacillus salivarius bacterial liquid and fermenting, and the auxiliary material is prepared by mixing rumex hanus and broken rice according to a mass ratio of 2: 1; experimental results show that compared with a mixture before fermentation, the fermented vinasse mixed feed has the advantages that the crude protein improvement rate can reach 19-21%, and meanwhile, acidic and neutral detergent fibers, zearalenone toxin, aflatoxin and vomitoxin can be effectively reduced. The strains used in the method are probiotics, and the biological fermentation feed not only can improve the utilization rate of feed raw materials, but also can inhibit the reproduction of harmful bacteria in animal intestinal tracts, promote the health of the animal intestinal tracts and improve the animal immunity.

The invention discloses application of chicken-derived saliva combined lactobacillus in laying hens in the later egg laying period. The chicken-derived saliva combined lactobacillus is used for preparing products for improving the production performance of the laying hens in the later egg laying period, improving the oxidation resistance of the laying hens in the later egg laying period and / or improving the egg quality of the laying hens in the later egg laying period. The chicken source combined lactobacillus salivarius is RS-11-1, is classified and named as the combined lactobacillus salivarius, is registered and preserved in China General Microbiological Culture Collection Center (CGMCC) on November 12, 2024, and has the preservation number of CGMCC No.32589. The chicken source combined lactobacillus salivarius has the advantages that the chicken source combined lactobacillus salivarius can be used for preparing the chicken source combined lactobacillus salivarius, and the chicken source combined lactobacillus salivarius can be used for preparing the chicken source combined lactobacillus salivarius; the chicken-derived saliva combined with lactobacillus can improve the intestinal health of laying hens in the late egg laying period, enhance the oxidation resistance of intestinal tracts, and improve the egg laying performance and egg quality of the laying hens in the late egg laying period.

The invention relates to the technical field of marine microorganisms, in particular to application of combined lactobacillus salivarius in preparation of products for improving metabolism of alcohol and uric acid, the combined lactobacillus salivarius NHNK-603 is preserved in the China Center for Type Culture Collection, and the preservation number is CCTCC NO: M 2024416. Experiments show; the NHNK-603 has the effects of inhibiting the growth of klebsiella pneumoniae, inhibiting the production of alcohol, agglutinating the klebsiella pneumoniae, inhibiting the virulence gene of the klebsiella pneumoniae, promoting alcohol metabolism, reducing alcohol damage, tolerating alcohol, degrading uric acid, inhibiting the activity of xanthine oxidase, promoting uric acid excretion, promoting the proliferation of Alistipes indinctus and synthesizing hippuric acid; the thallus biofilm increases the function of colonization on mucoprotein and intestinal epithelial cells, and can be applied to preparation of products for improving metabolism of alcohol and uric acid.

The invention relates to combined lactobacillus salivarius LS360 for preventing and / or improving female genital tract infection and application of the combined lactobacillus salivarius LS360. The combined lactobacillus salivarius LS360 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC NO.32134, and the combined lactobacillus salivarius LS360 has good biological characteristics and endurance capacity and can be used for preventing and / or improving female genital tract infection. The traditional Chinese medicine composition has a relatively strong inhibition effect on main vaginitis pathogenic bacteria, is effective on nutritional pathogenic bacteria, and can also reduce form transformation and biological membrane formation of the nutritional pathogenic bacteria and prevent and treat drug resistance; besides, the bacterial strain and the fermentation product can also reduce the content of pathogenic bacteria metabolites, regulate the secretion of cell factors and play a role in relieving inflammation, so that the bacterial strain and the fermentation product can be used for preparing products for preventing and treating female genital tract pathogenic bacteria infection, preventing and treating vaginitis and / or removing pudendum peculiar smell.

The invention relates to genetic engineering combined lactobacillus salivarius and application of the genetic engineering combined lactobacillus salivarius. The strain is classified and named as combined lactobacillus salivarius CTMT2, and the preservation number of the strain is CCTCC (China Center for Type Culture Collection) M 2025547. After an NIAAA model is injected into the stomach of an alcoholic liver mouse, the acetaldehyde level of the liver of the mouse is obviously reduced, and the alcoholic fatty liver symptom of the mouse is obviously relieved; after long-term intragastric administration of a high-glucose and high-fat modeling mouse, the acetaldehyde level in excrement of the mouse can be obviously reduced, the progress of liver fibrosis is improved, and good application prospects are achieved.

This invention discloses a fermentation process and application of wheat germ, belonging to the field of feed additive technology. The fermentation process includes the following steps: mixing Bacillus coagulans powder (accession number CGMCC No. 1.17145), Lactobacillus salivarius powder (accession number CCTCC NO: M 2022848), and steam-sterilized and cooled wheat germ; performing solid-state fermentation in a sealed environment; and then sterilizing with ozone after fermentation to obtain fermented wheat germ. This invention produces highly nutritious fermented wheat germ through simple steps. This fermented wheat germ can be used as a feed additive for laying hens, improving their production performance.

The invention provides a composition for inhibiting streptococcus angina and a preparation method of the composition, and belongs to the technical field of medicines. The preparation method comprises the following steps: carrying out water extraction on purslane and ginseng to obtain polysaccharide and an anti-inflammatory composition, mixing the anti-inflammatory composition and antibiotics, embedding the mixture in beta-cyclodextrin, forming a compound by the prepared inclusion compound, a magnetic gold nanocage and a probiotic secretion compound, loading the compound on lactobacillus salivarius LS02, uniformly mixing the compound with lactobacillus reuteri FPHC2951, lactobacillus acidophilus LA16 and polysaccharide, and carrying out freeze-drying to obtain the anti-inflammatory compound. The composition for inhibiting the streptococcus angina is prepared. The composition for inhibiting the streptococcus anginiae has good targeted inhibition and killing effects on harmful bacteria streptococcus anginiae, does not have drug resistance, has small side effects, is high in patient compliance, has good anti-oxidation, anti-inflammatory and antibacterial effects, is good in biocompatibility, and has a wide application prospect.

The present invention provides a salivarius lactobacillus 8-2 strain and an application thereof, wherein the salivarius lactobacillus 8-2 strain has been deposited in the General Microbiology Center of the China Microbiological Culture Collection Administration Committee, and the deposit number is CGMCC NO.30612. The salivarius lactobacillus described in the present invention has good acid resistance, is non-hemolytic, has strong antibacterial ability, can reduce the damage caused by salmonella infection, and can effectively promote the absorption function of intestinal mucosa, improve the production performance of laying hens, has the potential to be developed into a high-quality probiotic preparation for laying hens with both "antibiotic replacement" function and the function of promoting the repair of intestinal mucosal damage, and can be used in the preparation of laying hen antibiotic substitutes, including the application of the fermentation supernatant of the strain in the preparation of laying hen antibiotic substitutes.

The use of a bacterium of the species Lactobacillus salivarius in the manufacture of a food product, dietary supplement or medicament for treating cardiac dysfunction, particularly myocardial infarction, congestive heart failure, dilated cardiomyopathy or inflammatory heart disease (including endocarditis, inflammatory cardiomegaly and myocarditis) is disclosed.

The invention relates to a pharmaceutical composition for repairing oral gingivitis and a preparation method thereof, and belongs to the technical field of biological medicine, the pharmaceutical composition comprises a lactobacillus salivarius fermentation extract, a herba violae extract, golden cicada nymph extract peptide, guava polyphenol and resveratrol; the lactobacillus salivarius fermentation extract is obtained by carrying out aerobic fermentation and anaerobic fermentation on lactobacillus salivarius to obtain a fermentation product, and purifying and extracting the fermentation product through an XAD7HP macroporous adsorption resin column; the philippine violet herb extract is obtained by performing enzymolysis on whole philippine violet herb through pectinase and cellulase and then performing enzymolysis through compound protease to obtain zymolyte, and purifying and extracting the zymolyte through a compound adsorption column. The golden cicada nymph extracted peptide is obtained by purifying and extracting 5kDa zymolyte obtained by performing step-by-step enzymolysis on golden cicada nymphs through papain and trypsin through a Q agarose gel FF adsorption column. All the components are matched for use according to a certain proportion, so that the antibacterial coating is capable of precisely resisting bacteria, has efficient anti-inflammatory and anti-oxidation properties, and is safe and reliable.