14 results about "Lactobacillus salivarius" patented technology

This invention discloses a fermentation process and application of wheat germ, belonging to the field of feed additive technology. The fermentation process includes the following steps: mixing Bacillus coagulans powder (accession number CGMCC No. 1.17145), Lactobacillus salivarius powder (accession number CCTCC NO: M 2022848), and steam-sterilized and cooled wheat germ; performing solid-state fermentation in a sealed environment; and then sterilizing with ozone after fermentation to obtain fermented wheat germ. This invention produces highly nutritious fermented wheat germ through simple steps. This fermented wheat germ can be used as a feed additive for laying hens, improving their production performance.

The application discloses a cat oral cavity nursing probiotic composition and application thereof, and the probiotic composition comprises animal bifidobacterium and lactic acid bacteria, wherein the lactic acid bacteria is any one or a combination of multiple of salivarius, lactobacillus casei, enterococcus faecalis, lactobacillus rhamnosus, lactobacillus plantarum, lactobacillus acidophilus and lactobacillus reuteri; compared with single probiotic, the probiotic composition has better effect on oral cavity odor removal, can effectively improve cat oral cavity source halitosis, and can also reduce dental plaque formation, relieve gingivitis and dental caries, and can be applied to preparation of a cat oral cavity odor cleaner, and has good application prospect.

This invention discloses a *Ligilactobacillus salivarius* YS-SA09, with accession number CGMCC NO.37763 and Latin name *Ligilactobacillus salivarius*. This invention also discloses a *Citrus aurantium* ferment, obtained by fermenting *Citrus aurantium* with the aforementioned *Ligilactobacillus salivarius* YS-SA09. This invention further discloses the applications of *Ligilactobacillus salivarius* YS-SA09 and the *Citrus aurantium* ferment, which can effectively improve sleep in mice with insomnia models, effectively shorten sleep latency, and prolong sleep onset time; effectively improve depressive-like behavior in mice with CUMS models; significantly reverse the decrease in neurotransmitter levels caused by CUMS in mice, effectively increase the levels of GABA, 5-HT, DA, and NE in the serum of depressed mice; reduce serum TNF-α and IL-6 levels, and improve inflammatory factor levels.

The application discloses a lactobacillus salivarius ZY-01 with anti-salmonella and anti-inflammatory repair functions, the strain has been preserved in the China General Microbiological Culture Collection Center on March 9, 2026, and the preservation number is CGMCC No. 37873. The strain can inhibit salmonella, escherichia coli and staphylococcus aureus, can reduce the expression of IL-6, IFN-gamma and TNF-alpha pro-inflammatory factors by inhibiting the JAK-STAT signal pathway, and can promote the expression of IL-10 anti-inflammatory factors and EGF, EGFR and TGF-beta1 mucosal repair factors, so that intestinal anti-inflammation and mucosal repair are realized. The lactobacillus salivarius ZY-01, bacterial liquid, bacterial powder and fermentation product thereof can be used as core raw materials of animal feed additives, micro-ecological preparations and veterinary drugs, are used for preventing and controlling salmonella infection and improving intestinal health of animals in animal breeding, and have a wide application prospect.

The application discloses application of a fermented Gastrodia elata water extract in preparation of a product for preventing and treating androgen alopecia, and belongs to the technical field of probiotic fermentation and application, wherein the fermented Gastrodia elata water extract is prepared from fermented Gastrodia elata by Lactobacillus salivarius AACE1. The fermentation process realizes biological transformation of Gastrodia elata raw medicinal materials, reduces potential irritation of the Gastrodia elata, and makes the product more suitable for long-term scalp care. Animal model efficacy evaluation of the water extract proves that the water extract can significantly improve androgen alopecia symptoms and has a remarkable effect on preventing and treating androgen alopecia.

This invention belongs to the field of intestinal microbial technology, and specifically relates to a strain of *Lactobacillus salivarius* D3-8 and its application in the fermentation preparation of donkey-hide gelatin peptides. This strain was isolated from the intestines of healthy humans and is deposited at the China Center for Type Culture Collection (CCTCC), accession number CCTCC NO: M 20251921. *Lactobacillus salivarius* D3-8 can ferment and degrade donkey-hide gelatin, a large-molecule traditional Chinese medicine, into a series of low-molecular-weight donkey-hide gelatin peptides, showing broad application prospects in the fermentation and processing of donkey-hide gelatin and the preparation of donkey-hide gelatin peptides.

This invention provides a composition containing Lactobacillus salivarius HHuMin-U (KCCM13001P) for use in improving, preventing, or treating vaginitis or vulvitis. [Solution] A pharmaceutical composition for the prevention or treatment of vaginitis or vulvitis is provided, containing Lactobacillus salivarius HHuMin-U (KCCM13001P) as an active ingredient.

The present application relates to the technical field of microorganisms, and particularly relates to a saliva host-associated lactobacillus V118 and application thereof. The saliva host-associated lactobacillus V118 has good inhibiting capacity on Candida albicans and mold, has strong adhesion capacity, has good anti-inflammatory effect, can effectively improve female vaginitis, has good safety, and has good application prospect. The strain can be used as a new type of probiotic resource, used for developing female vaginal health products, filling the market gap, and promoting the scientific development of female microecological health products.

The application provides an antibacterial peptide composition, a preparation method and application, and comprises a composite probiotic core layer, an antibacterial lipopeptide loading layer and a CaCO3 nanocrystal buffered alginate / pectin composite microcapsule coating; the composite probiotic layer comprises a bacteria slurry composed of Ruminococcus lactaris CY12 and S. salivarius 7247 at a ratio of 1:1 in terms of viable bacterial number, and the total viable bacterial number is greater than or equal to 5.0x10 9 CFU / g; and the antibacterial lipopeptide layer comprises SEPs candidate peptides mined from human intestinal metagenome, and the total addition amount is 0.1%-0.5%. The antibacterial peptide composition, the preparation method and the application are used, gastric acid tolerance and colon targeting accuracy better than traditional pH-dependent coating are realized, natural synergy of maintenance and defense is realized, and excellent efficacy can be achieved without genetic engineering modification.

The present application belongs to the technical field of nutritional health food, and particularly relates to a composition for repairing oral mucosa and a preparation method and application thereof. The composition comprises, by weight of the composition: 2%-80% of yeast beta glucan, 0.5%-50% of lactobacillus salivarius powder, 0.5%-50% of lactobacillus acidophilus powder, and 0.5%-50% of paracasei lactobacillus powder. The composition for repairing oral mucosa and the auxiliary materials are further prepared into a functional food in the form of tablets, liquids, soft candies or powders. In the functional food, the composition as the main component plays a role in repairing and preventing damage to the oral mucosa. Meanwhile, the composition and the auxiliary materials are dissolved under the action of oral saliva enzymes, thereby fully contacting the oral mucosa and pathogens and emitting a sweet and sour taste, so as to bring a pleasant sensory experience to the oral cavity.

A composition for treating insomnia, comprising a probiotic complex and traditional Chinese medicine components. The probiotic complex comprises Lactobacillus plantarum, Bifidobacterium lactis, Lactobacillus crispatus, Lactobacillus acidophilus, Lactobacillus rhamnosus, Bifidobacterium bifidum, Lactobacillus reuteri, Lactobacillus casei, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus fermentum, Lactobacillus gasseri, Lactococcus lactis, Bifidobacterium longum, Lactobacillus salivarius, Bifidobacterium breve, Streptococcus thermophilus, Lactobacillus paracasei and Lactobacillus helveticus. The traditional Chinese medicine components are semen ziziphi spinosae, bulbus lilii, poria, semen nelumbinis and mori fructus. The composition may further comprise prebiotics selected from L-arabinose, β-glucan, inulin, erythritol, lactitol, vitamin C and γ-aminobutyric acid. The composition can be used for preparing pharmaceutical or food formulations, such as solid beverages, chewable tablets or oral lozenges. Clinical observation shows that the composition has the effect of relieving insomnia.

The present application relates to the field of biological medical technology, and in particular to saliva combined lactobacillus and its application in preparing a drug for treating EMT. The saliva combined lactobacillus NCU-03 has a probiotic property, can reduce the production of blood vessels and the proliferation of cells of endometrial ectopic lesions by inhibiting the expression of VEGF and PCNA, and can inhibit the development of endometrial ectopic by reducing the expression level of IL-6, IL-1beta and TNF-alpha. Therefore, the saliva combined lactobacillus NCU-03 can be used for treating endometrial ectopic.

The present invention provides compositions of Lactobacillus salivarius GKS9 and their use for reducing uric acid. The present invention relates to the use of Lactobacillus salivarius GKS9 for the preparation of a composition for reducing uric acid, wherein the composition comprises an effective dose of Lactobacillus salivarius GKS9 as active substance.