25 results about "Lactobacillus fermentum" patented technology

This invention belongs to the field of food fermentation technology, and specifically relates to a compound probiotic agent and its application in the preparation of fermented soy milk. This invention provides a compound probiotic agent composed of *Lactobacillus fermentum* NCPS LF01, *Pediococcus pentosaceus* NCPS PPE01, and *Lactobacillus acidophilus* NCPS LA01 in a volume ratio of 1-2:1:1, and applies this compound probiotic agent to the preparation of soy products, especially fermented soy milk. The beneficial effects of this invention are that fermented soy milk prepared using this compound probiotic agent has a rich flavor, and the total flavonoid and total phenolic content, as well as the in vitro DPPH free radical scavenging rate, are significantly superior to those of ordinary commercially available strains or other strains. In summary, this compound probiotic agent can effectively improve the retention level of active ingredients and antioxidant capacity of fermented soy milk, and has outstanding application value.

The application discloses a plant lactobacillus strain and application thereof, and belongs to the technical field of microorganisms. The preservation number of the strain is CGMCC No. 33864. The strain has good tolerance to gastrointestinal juice and bile salts and has no hemolytic activity. Concentrated cell-free supernatant prepared from the strain can inhibit salmonella, including inhibiting the growth of salmonella, killing bacteria, inhibiting or removing biofilm. Animal experiments show that the strain and the concentrated cell-free supernatant thereof can prevent salmonella infection, alleviate weight loss caused by infection, maintain intestinal barrier integrity, reduce the level of pro-inflammatory factors, alleviate tissue damage, improve the expression of colon tight junction proteins and mucin, promote the generation of short-chain fatty acids, and restore the intestinal flora structure. The application further provides a microbial preparation containing the strain and / or the concentrated cell-free supernatant thereof. The strain and the microbial preparation can be used for preparing products for resisting salmonella, preventing salmonella infection or improving intestinal health.

This invention discloses a method for enhancing the color and aroma of whole-component fruit juice through synergistic fermentation with lactic acid bacteria, belonging to the field of food processing technology. The method uses ripe mangoes / pineapples as raw materials. After washing, pitting (peeling), and low-temperature jet milling to retain all components, the juice undergoes compound enzymatic hydrolysis and optimization of its uniformity. A compound strain composed of *Lactobacillus plantarum*, *Lactobacillus fermentum*, and *Lactobacillus helveticus* is then inoculated. The mixture undergoes constant-temperature anaerobic fermentation. The process is optimized using fuzzy mathematical sensory evaluation and response surface methodology, resulting in a sensory score of 91.67 for mango juice and 90.83 for pineapple juice. The retention rate of carotenoids is increased by 25%-30%, the lactic acid content reaches 2.97-26.45 mg / g, and the relative content of esters in volatile aroma components increases to over 35%. Simultaneously, the total sugar content decreases by 3.7%-24.0%. This method solves the problems of dull color, weak aroma, and nutrient loss in traditional whole-component fruit juices. The product combines natural functionality with a unique fermented flavor, making it suitable for industrial production.

The application discloses a stomach-derived limosilactobacillus fermentum LAF-09 and application thereof, and the preservation number of the stomach-derived limosilactobacillus fermentum LAF-09 is GDMCC No. 65656. The inventor of the application screens a stomach-derived limosilactobacillus fermentum LAF-09 from stomach mucosa tissue of healthy people, the strain has strong acid resistance and high proliferation capacity in the stomach, has strong adhesion properties to stomach epithelial GSE-1 cells, can be effectively applied to prevent and treat gastric ulcers caused by indomethacin, and has no obvious side effects.

The present invention relates to a synergistic bioactive composition for women's health, and more particularly to compositions comprising Lactobacilli and Lactoferrin for supporting vaginal health. The invention specifically provides a composition comprising Lactobacillus crispatus, Lactobacillus jensenii, Lactobacillus fermentum, and Lactoferrin, formulated with one or more pharmaceutically acceptable excipients. The invention further pertains to compositions and kits intended for promoting a balanced vaginal microbiota, maintaining healthy vaginal conditions, and supporting overall vaginal ecosystem stability.

The application belongs to the technical field of microorganisms, and discloses Lactobacillus fermentum (L.f) LFSJ001 and application thereof in preparation of products for preventing or treating ulcerative colitis. The Lactobacillus fermentum LFSJ001 is independently isolated and identified. It is found through the use of DSS to construct a mouse colitis model that the Lactobacillus fermentum LFSJ001 combined with 5-Aminosalicylic Acid (5-ASA) can enhance the improvement of 5-ASA on the symptoms of colitis, including multiple indexes such as disease activity index, colon injury, and spleen index. It can be seen that the Lactobacillus fermentum LFSJ001 can be used as a combined drug of 5-ASA, enhance the efficacy of 5-ASA, inhibit the occurrence and development of ulcerative colitis, and improve the intestinal barrier. The application provides a new diagnosis and treatment direction and strategy for the prevention and treatment of ulcerative colitis.

The present invention relates to a composition for preventing, ameliorating or treating cognitive dysfunction or Alzheimer's disease comprising, as an active ingredient, Lactobacillus fermentum SRK414 strain which has accession number KCTC13687BP. The strain of the present invention is excellent in reducing barrier permeability and reducing amyloid beta and tau proteins and has an excellent effect in improving cognitive function, and accordingly, the strain can be useful for a food and therapeutic agent for same purposes.

The present application provides a kind of arabinoxylan with beneficial activity prepared with corn skin as raw material.The arabinoxylan is composed of xylose, arabinose, glucose, galactose, rhamnose, mannose, glucuronic acid, galacturonic acid, fucose, ribose according to the molar ratio of 104.6:82.6:21.0:16.8:8.9:5.1:4.3:1.6:1.3:1, and the molecular weight is 2.51-10 kDa.The present application uses xylanase Scxyn22 to prepare arabinoxylan with specific molecular weight distribution and monosaccharide composition, the molar ratio of arabinose / xylose reaches 0.79, has unique apparent viscosity and antioxidant activity, can promote the proliferation of lactobacillus fermentum and lactobacillus casei, and can be applied in food field as food stabilizer, food thickening agent and new prebiotic.

The present invention relates to a novel Lactobacillus fermentum HEM20792 strain, a composition comprising the strain or a culture thereof for preventing or treating chronic obstructive pulmonary disease (COPD), and the like. The composition comprising a Lactobacillus fermentum HEM20792 strain (KCTC14066BP) as an active ingredient, according to the present invention, inhibits lung tissue damage and suppresses immune cells, and thus can prevent or treat COPD including emphysema. Therefore, it is expected that the present invention can be used to help cure pulmonary disease by eliminating a fundamental cause of COPD.

This invention discloses a mixed-culture fermented Polygonatum sibiricum compound granule and its preparation method, belonging to the technical field of modern processing of traditional Chinese medicine and development of functional foods. The method includes: screening Lactobacillus casei, Lactobacillus fermentum, and Monascus purpureus as a mixed-culture combination based on the CRITIC-WASPAS multi-index comprehensive evaluation method; inoculating the mixed-culture combination into Polygonatum sibiricum culture medium to obtain Polygonatum sibiricum fermentation broth; compounding the Polygonatum sibiricum fermentation broth with aqueous extracts of sweet tea, Eucommia ulmoides, white kidney bean, and Litsea cubeba, and adding low-chain inulin, pea protein peptides, and gellan gum as co-solvents to obtain a compound solution; and freeze-drying to obtain the mixed-culture fermented Polygonatum sibiricum compound granule. This invention objectively screens dominant strains through a multi-index comprehensive evaluation method, and the compound system and co-solvents synergistically enhance the effect, improving the utilization rate of active ingredients. The resulting granule dissolves rapidly, disperses evenly, and has good antioxidant, hypoglycemic, and lipid-lowering activities.

The application discloses a kind of mixed lactic acid bacteria fermented sour pomegranate juice and preparation method thereof, belong to food processing technical field.The application uses sour pomegranate juice as raw material, adopts Lactobacillus acidophilus, Lactobacillus plantarum and Lactobacillus fermentum three kinds of lactic acid bacteria according to optimized proportion mixed fermentation, is made into fermented juice after deployment, concentration, sterilization and the like process.The application significantly improves the polyphenol content and antioxidant activity of sour pomegranate juice by specific strain combination and its fermentation process optimization, improves flavor quality, electronic tongue analysis shows that umami is increased by 32%, and alcohol thickness is enhanced by 6%, GC-IMS analysis shows that characteristic aroma components such as hexanal and limonene are increased by 1.95 times and 1.45 times respectively.The application uses erythritol to replace sucrose to prepare low-sugar juice, and the product has bright color, sour and sweet taste, unique aroma, good nutritional value and market application prospect.

The application discloses a raspberry composite strain fermentation process and application thereof, relates to the technical field of raspberry fermentation, and is characterized in that raspberry powder and water are uniformly mixed, sterilized, added with fructo-oligosaccharide, cultured, inoculated with a composite strain, and then subjected to fermentation culture to obtain raspberry fermentation liquor; the composite strain comprises at least two of lactobacillus plantarum, lactobacillus fermentum, lactobacillus reuteri, lactobacillus plantarum P9, lactobacillus rhamnosus and lactobacillus paracasei; the raspberry fermentation liquor is centrifuged, and the supernatant is obtained, thereby obtaining the raspberry fermentation liquor. The application takes the viable count of the fermentation system, the content of total phenol, total flavone and total acid as evaluation indexes, selects the composite strain of lactobacillus plantarum and lactobacillus fermentum, and makes clear that the composite strain fermentation raspberry has a significant advantage compared with single-strain fermentation, and the composite strain fermentation liquor not only has a significant inhibitory effect on alpha-glucosidase, but also has an obvious improvement effect on sugar metabolism disorder of IR-HepG2 cells.

This invention provides a mixture of three strains of Lactobacillus fermentum and Lactobacillus platarum, as well as its uses. [Solution] A composition comprising a mixture of Lactobacillus fermentum GB102, GB103 strains and Lactobacillus plantarum GB104 strain, and their lysates, cultures, or extracts of cultures as active ingredients, can be usefully used for the prevention or treatment of muscle-related diseases or obesity, such as by alleviating age-related muscle weakness symptoms or reducing age-related changes in the intestinal microbial environment.

This invention provides a probiotic composition for the prevention and / or treatment of vaginal infections and related diseases, and its use therein. The probiotic composition comprises *Lactobacillus plantarum* and *Lactobacillus fermentum*, wherein the gene sequence of the molecular marker of *Lactobacillus plantarum* has the nucleotide sequence shown in SEQ ID NO: 1, or the nucleotide sequence thereof is shown in SEQ ID NO: 1; and the gene sequence of the molecular marker of *Lactobacillus fermentum* has the nucleotide sequence shown in SEQ ID NO: 2, or the nucleotide sequence thereof is shown in SEQ ID NO: 2. The probiotic composition of this invention achieves better efficacy in treating vaginal infections, especially vulvovaginal candidiasis, compared to single strains therein and existing positive control drugs such as metronidazole suppositories.

This application belongs to the field of microbial technology, specifically disclosing the application of *Lactobacillus fermentum* BLF03 in anti-Candida activity. *Lactobacillus fermentum* BLF03 was deposited on November 6, 2025, at the China General Microbiological Culture Collection Center (CGMCC) with accession number CGMCC No. 36521. This application proposes a *Lactobacillus fermentum* BLF03 strain resistant to *Candida albicans* and *Candida krusei*, which can significantly inhibit the growth, reproduction, and hyphal transformation of *Candida albicans* and *Candida krusei* at the in vivo level, alleviate Candida-induced infection symptoms, reduce the expression level of the inflammatory marker procalcitonin (PCT) after Candida infection, improve the inflammatory stress response induced by infection, and has a significant protective effect against tissue damage caused by Candida invasion. It also has targeted preventive and adjunctive therapeutic effects on Candida infections in the urogenital tract and other sites, providing a new, safe, and highly effective strain for anti-Candida products.

This invention discloses a method for producing fermented duck with low nitrite residue, characterized by the following steps: marinating duck meat in 1100-1200 mL of marinade per kilogram of duck meat, ensuring the duck embryo is completely submerged in the liquid, for 20-28 hours at a temperature of 0-4°C; then ultrasonically cleaning the duck meat at 150-400W for 1-4 minutes, followed by air drying; and then uniformly spraying a fermentation agent composed of *Lactobacillus fermentum* and *Hansophilus d'Barry* onto the surface of the duck embryo at an inoculation amount of 10... 6 ~10 8 CFU / g, constant temperature and humidity chamber program temperature 14~18℃, relative humidity 65~70%, air drying for 6~8 days, to obtain fermented duck with low nitrite residue. The advantages are that it can better maintain the color of duck meat, efficiently degrade nitrite, inhibit fat oxidation and rancidity, delay the increase of TVB-N value, and extend the product shelf life.

This invention provides a probiotic composition for the prevention and / or treatment of vaginal infections and related diseases, and its use therein. The probiotic composition comprises *Lactobacillus curvatureii*, *Lactobacillus jenny*, *Lactobacillus gasseri*, *Lactobacillus plantarum*, and *Lactobacillus fermentum*. Experiments have demonstrated that the probiotic composition of this invention achieves better efficacy in treating vaginal infections, especially VVC, compared to single-strain probiotics and positive control drugs such as metronidazole suppositories and diclofenac sodium.

This invention relates to the field of microbial technology, specifically to a fermenting *Lactobacillus mucinus* S108, whose classification name is... Limosilactobacillus fermentum The preservation number is CGMCC No. 37055. *Lactobacillus fermentum* S108 can produce high levels of γ-aminobutyric acid (GABA), effectively improving sleep disorders by regulating the gut-brain axis mechanism; it has high anti-inflammatory activity, helping to improve human immunity, enhance physical resistance, and prevent chronic diseases; it can effectively improve intestinal flora, providing a favorable environment for the growth of beneficial bacteria such as lactic acid bacteria and bifidobacteria, effectively inhibiting the growth of pro-inflammatory bacteria such as *Desulfovibrio* in the intestine, reducing the proportion of harmful bacteria in the intestine, and maintaining intestinal flora balance.

The application discloses a lactic acid bacteria strain for improving diarrhea of laying hens and application of the lactic acid bacteria strain, and belongs to the field of lactic acid bacteria. The Lactobacillus fermentum is screened by the applicant. Compared with common lactic acid bacteria, the strain can well colonize in the intestinal tract of the laying hens, form a bacterial population advantage, and inhibit pathogenic bacteria infection. The strain plays a good role in fermentation of a protein feed composition, effectively improves the bacteriostatic activity of the feed, and has the effects of reducing the diarrhea incidence of the laying hens and improving the egg production rate of the laying hens. The protein feed composition is a lactic acid bacteria strain with excellent effects, and the protein feed composition prepared by using the strain also has good application value.

The present invention is directed to a composition of Lactobacillus fermentum for use in the treatment of a fructose-related disease and a related method of treatment.

This application belongs to the field of microbial technology and discloses a low-temperature resistant Lactobacillus and Lactococcus compound inoculant and its application in oat silage. This low-temperature resistant Lactobacillus and Lactococcus compound inoculant includes Lactobacillus helveticus T3, Lactobacillus fermentum 1761, and Enterococcus faecalis CTB. This low-temperature resistant, high-performance Lactobacillus and Lactococcus compound inoculant not only maintains stable and efficient functional activity in extreme environments of 5℃ to -20℃, but also rapidly establishes an acidic environment during silage in natural environments (-20℃ to 17℃), effectively inhibiting protein degradation and putrefactive microbial activity, releasing more nutrients, improving silage stability and preservation, and further enhancing fermentation efficiency. Simultaneously, it has lower costs, good economic viability and prospects for large-scale application, providing a reliable and innovative technical solution for the efficient resource utilization of high-fiber raw materials in high-altitude and cold regions.

A composition for treating insomnia, comprising a probiotic complex and traditional Chinese medicine components. The probiotic complex comprises Lactobacillus plantarum, Bifidobacterium lactis, Lactobacillus crispatus, Lactobacillus acidophilus, Lactobacillus rhamnosus, Bifidobacterium bifidum, Lactobacillus reuteri, Lactobacillus casei, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus fermentum, Lactobacillus gasseri, Lactococcus lactis, Bifidobacterium longum, Lactobacillus salivarius, Bifidobacterium breve, Streptococcus thermophilus, Lactobacillus paracasei and Lactobacillus helveticus. The traditional Chinese medicine components are semen ziziphi spinosae, bulbus lilii, poria, semen nelumbinis and mori fructus. The composition may further comprise prebiotics selected from L-arabinose, β-glucan, inulin, erythritol, lactitol, vitamin C and γ-aminobutyric acid. The composition can be used for preparing pharmaceutical or food formulations, such as solid beverages, chewable tablets or oral lozenges. Clinical observation shows that the composition has the effect of relieving insomnia.

The present application relates to the technical field of microorganism and fermentation engineering, and particularly relates to a high-density fermentation method of lactobacillus fermentum. Seed liquid of lactobacillus fermentum HEW-A846 is inoculated into a fermentation medium containing a composite nitrogen source, a UiO-66-NH2 type MOF material is added in stages, and sugar feeding is performed based on a pH and DO double-signal coordinated triggering feeding strategy. The present application realizes high-density fermentation of lactobacillus fermentum HEW-A846 by in-situ selective adsorption of lactic acid by MOF to release product feedback inhibition, combined with precise feeding control. Under optimal process conditions, the viable cell count in a 5L fermenter can reach 3.28x10 10 CFU / mL, the lactic acid accumulation amount is reduced to 11.5 g / L, the process is scaled up to 20m 3 L, the scale-up deviation is less than 10%, and the process has good industrial application prospect.