394 results about "Lactobacillus fermentum" patented technology

The invention provides an intestinal tract micro-ecological preparation and its preparing process, wherein each 100g of the product contains bifidobacteria 1.0-20.0g, Lactobacillus acidophilus 1.0-25.0g, Streptococcus thermophilus 1.0-25.0g, Bulgarian subspecies of Lactobacillus fermentum 1.0-25.0g, saccharomycete 1.0-35.0g, and right amount of isomaltose hypgather, fructooligosaccharide, and many kinds of vitamins.

The invention provides compound probiotics as well as a production process and an application thereof to a leavening agent. The compound probiotics are obtained as follows: strains with strong tolerance and excellent fermentation performance are combined and proportioned to prepare the dry powder of probiotics by virtue of strain activation and cultivation, fermentation, separation and vacuum low-temperature drying; and then the dry powder of probiotics is compounded and packaged to obtain the complex probiotics. A continuous vacuum low-temperature drying process is adopted, the period is shortened and the yield is improved; and the complex probiotics comprises lactobacillus plantarum, lactobacillus fermentum, lactobacillus casei and lactobacillus rhamnosus in a ratio of (2-8) to (1-6) to (1-4) to (1-3); during application, every ton of vegetable can be well fermented within 3-5 days by use of 0.2-1kg of the leavening agent at a fermenting temperature of 20-30 DEG C, wherein the fermentation time is shortened by 50% in comparison with that in the conventional method, the yield of the salted and preserved vegetable is over 75%. The multipurpose probiotics leavening agent prepared by the production process disclosed by the invention can be used for the vegetable fermenting industry and the feed fermenting industry, so that a realistic problem in agricultural production and a food processing process is solved; and meanwhile, the product quality and the production efficiency are improved.

The invention discloses a biomarker capable of detecting diseases. The biomarker at least comprises one of the following microbes or the combination of the following microbes: Akkermansia muciniphila, Bacteroides fragilis, Clostridium bolteae, Clostridium hathewayi, Clostridium sp.HGF2, Clostridium symbiosum, Eubacterium limosum, Lactobacillus fermentum, Lactobacillus salivarius, Ruminococcus torques, Streptococcus anginosus, Streptococcus infantis, Bacteroides stercoris, Bacteroides uniformis, Bilophila wadsworthia and Clostridiales sp.SS3 / 4. The invention further discloses an application of the biomarker for determining inflammatory bowel diseases. The invention also discloses a method, a system and a kit for detecting the biomarker in a tested object. According to the invention, through the research on intestinal flora, and through the high-throughput genome sequencing, the biomarker with high relativity with the inflammatory bowel diseases is screened out, and then the biomarker is utilized for accurately and efficiently detecting and diagnosing the inflammatory bowel diseases, and further used for monitoring the treatment effect for the disease.

The invention discloses a lactobacillus fermentum and an application thereof. The lactobacillus fermentum HAFI5007 is preserved in the China General Microbiological Culture Collection Center on March 11, 2011 and the registration number of the lactobacillus fermentum HAFI5007 is CGMCC No.4648. The lactobacillus fermentum is mainly utilized as an additive of animal feeds, can improve a nutrient digestibility, a microbial composition in a gastrointestinal tract, functions of intestinal mucous protein expression and intestinal mucosa immunization and an antioxidant defense system of a pig, and reduce oxidative damages produced by an oxidative stress. Therefore, the lactobacillus fermentum can improve a production performance of pigs.

The present invention belongs to the technical field of functional foods and relates to a functional probiotic solid beverage capable of maintaining intestinal health and improving immunity and a preparation method thereof. The functional probiotic solid beverage is composed of the following components in parts by weight: 20-30 parts of sorbitol, 10-30 parts of skim milk powder, 10-20 parts of stachyose, 1-20 parts of resistant dextrin, 1-15 parts of whole milk powder, 1-15 parts of isomaltitol, 1-10 parts of isomaltooligosaccharide, 1-10 parts of oligofructose, 0.01-1 part of bifidobacteriumlongum powder, 0.01-1 part of bifidobacterium lactis powder, 0.01-1 part of lactobacillus acidophilus powder, 0.01-1 part of lactobacillus rhamnosus powder MP-108, 0.01-1 part of lactobacillus paracasei powder and 0.01-1 part of lactobacillus fermentum powder. The present invention also provides the preparation method of the functional probiotic solid beverage. The functional probiotic solid beverage is prepared by using a modern technology, convenient to carry and high in safety. Clinical trials show that compared with the probiotic group and the prebiotic group, the functional probiotic solid beverage has remarkable effects on maintaining the intestinal health and enhancing the immunity.

The invention relates to anthropogenic lactobacilus fermentum grx07 with a protection role on chronic alcoholic liver damage and application thereof. The lactobacilus fermentum grx07 strain disclosed by the invention is a probiotic strain separated from intestinal tracts of people in a Rugao longevity village of Jiangsu, the strain is preserved in China General Microbiological Culture Collection Center, and the preservation number is CGMCC No.8874. The lactobacilus fermentum grx07 strain has significant in vitro antioxidant ability and pathogenic bacteria inhibition ability, the rat blood fat of chronic alcoholic liver damage and the toxin level in serum can be significantly reduced, expression of liver inflammatory cytokines is reduced, the inflammatory reaction of the liver is relieved, the expression quality of antioxidant specific protein Nrf2 of the liver is increased, and the liver cell apoptosis percentage is reduced. Therefore, the anthropogenic lactobacilus fermentum grx07 has a significant protective effect on the chronic alcoholic liver damage.

Variant of the bacterium Lactobacillus fermentum and its use in treating gastrointestinal disorders, disorders of the mucosal surfaces or disturbances in the immune system or status of a subject.

The present invention provides an antiallergic agent containing, as an active ingredient, lactic acid bacteria selected from the group consisting of lactic acid bacteria of the species Lactobacillus acidophilus, Lactobacillus fermentum, and combinations thereof. The antiallergic agent is capable of improving allergic diathesis by reducing the IgE level, which is contributive to development of Type I allergy, and is easy to take and highly safe. The present invention also provides use of the antiallergic agent for reducing allergy, and a method for reducing allergy using the antiallergic agent.

The present invention relates to four kinds of lactobacilli, including Lactobacillus gasseri with preservation number of CGMCC No. 0840, Lactobacillus reuteri with preservation number of CGMCC No. 0841, Lactobacillus acidophilus with preservation number of CGMCC No. 0842 and Lactobacillus fermentum with preservation number of CGMCC No. 0843, separated from piglet intestinal tract and bred. The combination of the four kinds of lactobacilli is used in preparing the probiotics preparation for preventing and treating piglet ablactation diarrhoea and promoting growth, and the probiotic preparation is added into feed for ablactated piglet to prevent and treating diarrhoea and promote its growth.

The invention relates to a probiotic composition, and discloses a probiotic composition beneficial for a glycolipid metabolic function and a preparation and application of the composition. The probiotic composition comprises some of the following nine probiotics: bifidobacterium longum, bifidobacterium breve, lactobacillus gasseri, lactobacillus rhamnosus, lactobacillus salivarius, lactobacillus crispatus, lactobacillus plantarum, lactobacillus fermentum and lactobacillus casei. Different strains in the probiotic composition cooperate with each other, so that the probiotic composition has thefunction of adjusting glycolipid metabolism, and has certain effect on serum total cholesterol, triglycerides, insulin beta-cell functions and diabetes mellitus improvement.

The invention discloses a lactobacillus fermentum strain suitable for table vinegar brewing, wherein the classification name of the lactobacillus fermentum strain is Lactobacillus fermentum HS3-7, the Lactobacillus fermentum HS3-7 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation place is the Institute of Microbiology of Chinese Academy of Sciences located in 3, Courtyard 1, West Beichen Road, Chaoyang District, Beijing, the accession number is CGMCC NO.12226, and the preservation data is March 18, 2016. The invention further provides ready-to-use bacteria powder of the lactobacillus fermentum strain and applications of the bacteria powder. After the bacteria powder is used, the number of lactobacillus in table vinegar or other vinegar products can be obviously improved, the content of non-volatile acid is increased, and the flavor and quality of the product are improved.

The present invention discloses Lactobacillus fermentum HY01 with effects of intestinal tract function regulation and colitis prevention, and uses thereof, wherein the preservation number of the Lactobacillus fermentum HY01 is CCTCCM2015792. According to the present invention, the in vitro tolerance of the Lactobacillus fermentum HY01 is strong, wherein the survival rate of the Lactobacillus fermentum HY01 is 103.73+ / -8.60% after the Lactobacillus fermentum HY01 is treated for 3 h in the artificial gastric juice with the pH value of 3.0, the Lactobacillus fermentum HY01 can grow at the bile salt concentration of 0.3%, the growth efficiency is 21.62+ / -0.86% of the growth efficiency of the bile salt-free culture, and the Lactobacillus fermentum HY01 has good in vitro tolerance; and the in vivo mouse test results show that the Lactobacillus fermentum HY01 can alleviate the colonic shortening and the colonic edema of the colitis mice, and the inflammatory cell infiltration and the mucosal injury in colon, such that the Lactobacillus fermentum HY01 has the colitis prevention effect.

The strain of micro-organism Lactobacillus fermentum ME-3 is a novel anti-microbial and anti-oxidative probiotic. It has a high anti-microbial effect on Escherichia coli, Shigella sonnei, Staphylococcus aureus, Salmonella typhimurium, and moderate activity against Helicobacter pylori strains. The strain of micro-organism possesses Mn-superoxide dismutase and both its lysates and intact cells have high anti-oxidative activity, increasing the glutathione red-ox ratio in blood sera and able to capture toxic hydroxyl radicals. The strain of micro-organism could be used as a probiotic for the production of functional food (yoghurt, cheese) and non-comestibles (tablets, capsules) for the prophylaxis of intestinal and uroinfections, both for the prevention and treatment of chronic diseases, caused by prolonged oxidative stress.

The present invention discloses one kind of Lactobacillus fermenti CMS-H002 in the preservation number of CCTCC No. M 206110. The present invention discloses also the application of the Lactobacillus fermenti and medicine composition, food, health product and food additive containing the Lactobacillus fermenti. The Lactobacillus fermenti CMS-H002 of the present invention may be used in treating ulcerative colitis and other rectum and colon diseases effectively.

The present invention relates to microorganisms for preventing or treating obesity or diabetes mellitus which have excellent viability and produce polysaccharides efficiently in the intestines. More particularly, is directed to microorganisms for preventing or treating obesity or diabetes mellitus, which are capable of reducing the amount of monosaccharides or disaccharides that can be absorbed into the intestine by converting those mono or disaccharides into polymeric materials that cannot be absorbed in the intestines. The present invention is also directed to a pharmaceutical composition containing pharmaceutically effective amount of the microorganisms and a food composition containing the microorganisms as an active ingredient. Preferred microorganisms are Lactobacillus reuteri KCTC-10301BP and Lactobacillus fermentum KCTC-10458BP.

The invention discloses a lactobacillus fermentum with CCTCC (China Center for Type Culture Collection) NO: M2011370, and is a natural bacterial strain obtained from fermented sausage. After primary optimization, yield of gamma-aminobutyric acid is about 38g / l, which is the highest yield in the existing non-tank fermentation of lactobacillus for producing gamma-aminobutyric acid. Besides, a policy that glucose and organic nitrogen source are fed in tank fermentation is adopted, and the yield can reach up to 75g / l. The lactobacillus fermentum disclosed by the invention has capability of producing gamma-aminobutyric acid with high yield, good adaptability to culture media and culture conditions and natural strain source, thus a good industrial application prospect is given to the lactobacillus fermentum disclosed by the invention.

The invention discloses a lactobacillus fermentum Lee working fermenting agent product and application thereof to prevent constipation and keep healthy. Lactobacillus fermentum Lee is preserved in China Center for Type Culture Collection with the preservation number of CCTCCM2013512. Lactobacillus fermentum Lee is capable of normally growing in human intestinal tracts. Mouse in-vivo tests show that lactobacillus fermentum Lee is capable of alleviating the mouse body weight mitigating trend caused by constipation, accelerating melaena discharging time, improving intestinal propulsive rate, increasing levels of MTL, Gas, ET, AchE, SP and VIP in serum to different degrees, reducing SS factor level, increasing food intake and water intake, and reducing the decrease trend of defecation amount, defecation particle quantity and water content in faeces, gives play to effects similar to that of constipation-treating medicines, and shows certain constipation prevention effect. The optimum usage dosage is 1.0*10<9> CFU for per kg body weight.

The invention discloses a probiotics-Chinese herbal medicine compound composition capable of loosening bowels to relieve constipation and application of the probiotics-Chinese herbal medicine compoundcomposition and belongs to the technical field of health-care foods. The composition comprises 13-15 kinds of lactobacillus rhamnosus, lactobacillus plantarum, lactobacillus paracasei, bifidobacterium lactis, lactobacillus acidophilus, bifidobacterium longum, lactobacillus reuteri, lactobacillus helveticus, lactobacillus fermentum, lactobacillus johnsonii, lactobacillus casei, lactobacillus crispatus, bifidobacterium breve, bifidobacterium bifidum and bifidobacterium infantis, 10-13 kinds of isomalto-oligosaccharide, inulin, lactitol, stachyose, fructo-oligosaccharide, xylo-oligosaccharide, Mannan-oligosaccharide, galacto-oligosaccharide, oat beta-glucan, glucan, soluble soybean polysaccharide, resistant dextrin and chitosan-oligosaccharide and 2-4 kinds of malts, fructus crataegi, blackplums and fermented soybeans. According to the probiotics-Chinese herbal medicine compound composition and the application thereof, probiotics, prebiotics and traditional Chinese medicine powder are compounded and can jointly promote intestinal canal health.

The present invention is directed to a composition for use in liver function improvement, blood alcohol level reduction and in-vivo antioxidant activity enhancement, comprising Lactobacillus brevis HY7401, Lactobacillus fermentum CS332, Lactobacillus acidophilus CSG, Bifidobacterium longum HY8001, an Alder tree extract, a Selfheal extract, a milk thistle extract, a green bean-rice bran fermentation extract, a turnip extract, a tomato extract, a broccoli extract, a pineapple extract, a colostrum powder, betaine, vitamin B1, B2, B3, B6, B9, B12, C, and E. The composition can improve declined liver functions and shows excellent hepatoprotective and hepatocurative activity against alcohol on excessive or habitual drinking with the ability to reduce blood alcohol levels. Its superior enhancement of in-vivo antioxidant activity also contributes to the use of the composition in the prevention of liver diseases and the improvement of liver functions. Also disclosed are fermented dairy foods, beverages, and health foods, containing the composition as an effective component.

The invention discloses Lactobacillus fermentum suo for adjusting intestinal tract motion and preventing constipation and a use thereof. The Lactobacillus fermentum suo has a preservation number of CCTCC NO: M2013511, has strong acid resistance, has a survival rate of 92.46+ / -4.06% after being arranged in an artificial gastric juice with a pH value of 3.0 for 3h, can slowly grow in cholate with a concentration of 1.0%, has a growth rate 17.36+ / -1.19% that of cholate-free culture, has cell hydrophobicity of 68.44+ / -2.48% and can normally grow in the human intestinal tract. Lactobacillus fermentum suo can relieve constipation-caused mouse weight reduction, reduce tarry stool excretion time, improve a small intestine propulsion rate, improve serum MTL, Gas, ET, AchE, SP and VIP factor levels to different degrees, reduce a SS factor, improve food intake and water intake, relieve reduction of a stool excretion mount, the number of stool particles and stool water content and can produce a certain constipation prevention effect similar to those of constipation treatment drugs.

The present invention provides an isolated microorganism strain, Lactobacillus fermentum GM-090, which is found to be effective in stimulating IFN-γ secretion and / or treating allergy. The use of the Lactobacillus fermentum GM-090 in stimulating IFN-γ secretion and / or treating allergy is also provided.

Six hop acids are common to hops and beer: alpha acid, beta acids, isoalpha acids, rho-isoalpha acids, tetrahydro-isoalpha acids, and hexahydro-isoalpha acids. The six hop acids were tested to determine which were the most effective in inhibiting the growth of bacteria common to fuel ethanol production. The bacteria used in the tests were Lactobacillus brevis and Lactobacillus fermentum. The minimum inhibitory concentrations (MIC) of the hop acids were determined using MRS-broth. Molasses mash and wheat mashes were used as the growth media for the fermentations. In all cases the hop acids controlled the growth of these two lactobacillus bacteria with tetrahydroisoalpha acid, hexahydroisoalpha acid, and isoalpha acid killing the most bacteria at the lowest MIC. Treating yeast propagators, steep tanks, and fermenters with a minimum inhibitory concentration of hop acids will stop bacteria growth, increase ethanol yields and avoid the need for antibiotics.

The invention relates to the field of microorganisms, and discloses lactobacillus fermentum capable of reducing blood uric acid. The strain is named 2644 strain, and is preserved at the China GeneralMicrobiological Culture Collection Center on 19th, November, 2018, and a microbial preservation number is CGMCC NO.16754; and the preservation authority address is NO.3 1# Courtyard, Beichen West Road, Chaoyang District, Beijing, and the microorganism is classified and named Lactobacillus fermentum. The strain can effectively reduce the content of the blood uric acid; and not only can intake of exogenous purines be reduced, but also discharge of internal uric acid from an intestinal tract can be promoted so that the blood uric acid level of a body can be more effectively controlled.

The invention discloses a lactobacillus fermentum strain LF8005 which is preserved in China Center for Type Culture Collection on November 9, 2020, the address is Wuhan University, Wuhan, China, and the preservation number is CCTCC NO: M2020704. The invention also provides a lactobacillus fermentum culture and a preparation method thereof, and the lactobacillus fermentum culture has the effects of inhibiting escherichia coli, staphylococcus aureus and candida albicans, scavenging free radicals, resisting oxidation and preventing skin inflammation. The lactobacillus fermentum is separated from a traditional fermented dairy product, the safety of the lactobacillus fermentum is guaranteed, macromolecular active matter such as polysaccharide, glycoprotein and biotin can be secreted, so that the viscosity of fermentation liquor is increased, and the lactobacillus fermentum serves as a natural active component to be added and applied to skin care products. The product is low in irritation, high in safety and not prone to dependence, mainly improves the skin environment and performs prevention and protection on the skin, adapts to the development requirements of current skin care cosmetics and can be safely added and applied to skin care products.

The invention relates to a lactobacillus expansible vaginal suppository as well as a preparation method and a detection method thereof. The expansible vaginal suppository comprises an expansion vector and a drug-containing matrix which coats the surface of the expansion vector and is formed by lactobacilli and a matrix, wherein the lactobacilli include lactobacillus plantarum, lactobacillus acidophilus, lactobacillus fermentum, lactobacillus salivarius, lactobacillus crispatus, lactobacillus casei, lactobacillus paracasei, lactobacillus rhamnosus, lactobacillus reuteri and lactobacillus bulgaricus, and the various lactobacilli can develop a significant synergistic effect together; and the drug-containing matrix further consists of an emulsifier, a sustained-release agent and carnauba wax. The lactobacillus expansible vaginal suppository provided by the invention, on the basis of seven unique advanced technologies, has effects of preventing effusion of medicine liquid, guaranteeing high stability, guaranteeing a lasting curative effect and the like.

The present invention relates to a novel process for the selection of new probiotic strains which comprises the following steps: a) selecting for non-pathogenic strains which are capable of surviving in breast milk and / or amniotic fluid, and b) selecting for non-pathogenic strains which are able to be transferred to breast milk and / or amniotic fluid after oral intake in healthy individuals without colonizing other internal organs except mucousas. The invention also provides new Lactobacillus strains, which are: CECT5711 (Lactobacillus coryniformis), CECT5713 (Lactobacillus salivarius subsp. salivarius), CECT5714: (Lactobacillus gasseri, formerly L. acidophilus), CETC5715: (Lactobacillus gassen), and CECT5716: (Lactobacillus fermentum); and refers to their use for the prophylaxis or treatment against digestive, infective, neuro-degenerative and immune related diseases such as allergies or inflammatory diseases.

A biological fermentation pig forage is prepared from the following raw materials in parts by weight: 45-53 parts of corn flour, 8-10 parts of herb of common nipplewort, 3-4 parts of konjac glucomannan, 3-4 parts of glucosamine sulfate, 35-40 parts of soybean meal, 35-40 parts of barley vinasse, 17-25 parts of wheat bran, 10-13 parts of euglena, 3-4 parts of spora lygodii, 1-1.5 parts of lactobacillus fermentum, 1-1.5 parts of aspergillus niger, 1.5-2 parts of lactobacillus plantaum, 1.5-2 parts of lactobacillus johnsonii, 0.2-0.3 part of sodium selenosulfate, 3-4 parts of vitamin e acetate, and 10-12 parts of illite powder. The biological fermentation pig forage is improved in digestion rate, and is capable of increasing digestion capability of animals on the forage and improving animal growth performance, especially is capable of enhancing immunity, possesses protrude effects on reducing pig cold and mycoplasma pneumoniae of swine, and is capable of improving pork tenderness and reducing muscle shearing force.

The invention relates to a novel strain, Lactobacillus fermentum strain, and a use thereof. Specifically, novel Lactobacillus fermentum PL9988, novel Lactobacillus fermentum PL9037, novel Lactobacillus fermentum PL9038, novel Lactobacillus fermentum PL9039 and novel Lactobacillus fermentum PL9040 strains, isolated from adults in a longevity village, and culture fluids thereof: have no antibiotic resistance transfer; have excellent intestinal cell adhesiveness, acid resistance and bile resistance; inhibit harmful pathogenic organisms in intestines; and have an immunity-enhancing effect, an endotoxin shock suppression effect and an antioxidant effect. In particular, Lactobacillus fermentum PL9988 strain significantly satisfies all of the above-mentioned conditions as a probiotic, and thus can be effectively used as a probiotic for intestinal health and defecation improvement and enhancement, or as a health food.

The invention relates to the field of microorganisms, and discloses lactobacillus fermentum with a weight reducing function and an application of the lactobacillus fermentum. The lactobacillus fermentum is named as WHH3906, is separated from butter collected in Tibet Autonomous Region in China, is preserved in China General Microbiological Culture Collection Center on March 13, 2020, has a preservation number of CGMCC NO.19472, and is classified and named as lactobacillus fermentum. The lactobacillus fermentum strain can effectively reduce serum leptin level to recover leptin sensitivity of anorganism, effectively prevent and treat obesity, relieve non-alcoholic fatty liver and relieve chronic inflammation. After being compounded with lactobacillus plantarum 1701, the lactobacillus fermentum can synergistically relieve chronic inflammation.

The invention discloses Lactobacillus fermentum zhao capable of regulating intestinal movement and preventing constipation and application thereof, wherein the preservation number of the Lactobacillus fermentum zhao is CCTCCM2013513. The strain has higher acid resistance, has a survival rate reaching 85.12% plus / minus 5.18% after staying in pH3.0 artificial gastric juice for 3 h, can grow slowly in cholate with the concentration of 1.0% and has a growth efficiency reaching 18.33% plus / minus 0.52% of that of cholate-free culture. The hydrophobicity of Lactobacillus fermentum zhao cells is up to 70.80% plus / minus 0.61%. The Lactobacillus fermentum zhao can grow normally in human intestinal tracts. In-vivo tests using mice show that the Lactobacillus fermentum zhao can reduce the weight reduction tendency of the mice, shorten the time of defecation of dark stool, improve the peristalsis of small intestines, increase MTL, Gas, ET, AchE, SP and VIP factors to different extents, reduce SS factors, increase food consumption and water consumption, reduce the tendency that stool amount, stool pieces and stool water content decline, play an effect similar to that of a constipation medicine and show a certain constipation prevention effect.