40 results about "Chronic alcoholic" patented technology

An anti-oxidative Lactobacillus rhamnosus CCFM1107 can relieve chronic alcoholic liver injury, and L. rhamnosus CCFM1107 can be used in preparing dairy products as starter culture. The dairy products of this invention include milk, milk powder, milk capsules or fermented milk containing L. rhamnosus CCFM1107. It has strong abilities of anti-oxidation, scavenging diphenyl picrylhydrazyl (DPPH) radical and hydroxyl radical, inhibiting lipid peroxidation, tolerating cholate, chlorine sodium and pH, and can improve liver function and antioxidative index, lower serum endotoxin level and regulate intestinal flora distribution, thus effectively relieving alcoholic liver injury of mice.

The invention relates to a composition capable of timely preventing alcoholism and protecting the stomach, the liver and the brain and application thereof. The composition is prepared from taurine, kudzuvine roots, semen hoveniae, gamma-aminobutyric acid, sodium alginate and fructo-oligosaccharide. The composition can be prepared into different forms of healthcare food and nutrient fortification food and is suitable for timely preventing alcoholism and protecting the stomach, the liver and the brain for a drinker and suitable for adjuvant therapy of injures such as chronic alcoholic livers and brains; in addition, the raw materials are food-grade raw materials, and therefore the advantages of being natural and safe are achieved.

The invention discloses a traditional Chinese medicine extract mixed preparation which comprises a baical skullcap root extract, a cape jasmine fruit extract and an Indian buead extract, wherein the mixture ratio of the three is (80-100): (80-100): (100-150); and the content of scutelloside in the baical skullcap root extract is above 90%, the content of geniposide in the cape jasmine fruit extract is above 90%, and the content of polysaccharides in the Indian buead extract is above 50%. The traditional Chinese medicine extract mixed preparation has the effects of protecting liver and benefiting gallbladder, and can be used for preparing medicaments or health care products for protecting the liver and benefiting the gallbladder, or the medicaments for treating obstructive jaundice, or the medicament for treating cholestasis, or the medicaments for treating chronic alcoholic liver injury. The effects of the traditional Chinese medicine extract mixed preparation for and benefiting the gallbladder and protecting the cholestasis of rats caused by bile duct ligation and ANIT (alpha-naphthylisothiocyanate) and the alcoholic liver injury of the rats are obviously better than conventional control medicaments, and the liver injury degree and the icterus index can be significantly reduced.

The invention discloses a lactic acid bacteria formula for preventing acute and chronic alcoholic liver injury and application thereof. Lactobacillus plantarum KLDS1.0344 and lactobacillus acidophilusKLDS1.0901 have good gastrointestinal fluid tolerance simulating capacity, have certain adhesion capacity to HT-29 cells and have basic probiotic characteristics; the lactobacillus plantarum KLDS1.0344 and the lactobacillus acidophilus KLDS1.0901 can prevent acute alcoholic liver injury; and the lactobacillus plantarum KLDS1.0344 and the lactobacillus acidophilus KLDS1.0901 can prevent chronic alcoholic liver injury. Specifically, the lactobacillus plantarum KLDS1.0344 and the lactobacillus acidophilus KLDS1.0901 have the functions of reducing the liver index, improving the intestinal barrier, improving the liver function, reducing the inflammation level in the liver, increasing the content of short-chain fatty acid in the intestinal tract, reducing protein expression of CYP2E1 in the liver and the like.

The invention relates to a natural medicine composition capable of preventing and treating alcoholic liver injuries. The composition is prepared from total saponins of ginsengs, total flavonoids of ampelopsis grmsedntara leaves, total flavonoids of bamboo leaves and isodon lophanthoides var.gerardianus extract. The invention further relates to application of the composition to preparation of health foods capable of preventing and treating acute and chronic alcoholic liver injuries and preparation of health foods, beverages and tea capable of preventing and treating non-alcohol fatty liver. All the components of the composition have good synergistic effect and remarkable curative effect; raw materials are easily obtained, the cost is relatively low and the practicability is relatively strong.

The invention discloses new use of a globe artichoke stem-leaf extract. The globe artichoke stem-leaf extract has the efficacies of resisting inflammation and preventing and treating chronic alcoholic liver injury and non-alcoholic fatty liver disease by decreasing the expression quantity of TLR4, NF-kappaB, IL-1beta, IL-6 and IL-8. The globe artichoke stem-leaf extract disclosed by the invention can play roles of multiple effects, multiple target points and multiple functions. Compared with existing oral alcohol-dispelling liver-protecting drugs, the globe artichoke stem-leaf extract has the advantages that the safety is relatively high; the globe artichoke stem-leaf extract is convenient to prepare and wide in market application prospects, can be applied to the preparation of medicines, health foods, food additives, feed additives, antioxidants and the like and has wide application prospects and huge economic benefits in the fields of processing and application.

The invention discloses an application of methyl ferulic acid in preparation of a medicine for preventing and treating alcoholic liver disease. An ethanol induced L-02 cell damage model proves that the methyl ferulic acid can reduce the MDA level and improve the activity of SOD, GSH-Px and CAT. According to animal experiments, the methyl ferulic acid can remarkably reduce the contents of ALT, AST and MDA of the rat suffering acute alcoholic liver injury and obviously improve the activity of SOD, GSH-Px and CAT; and the methyl ferulic acid can obviously reduce the content of triglyceride (TG), ALT, AST and MDA of the rat suffering chronic alcoholic liver injury and noticeably improve the activity of SOD, GSH-Px and CAT. The results of the cell and animal experiments indicate that the methyl ferulic acid has an exact effect in preventing and treating alcoholic liver disease and can be used for preparing a medicine for preventing and treating alcoholic liver disease independently or in combination.

The invention discloses a novel natural herbal compound composition with sobering and liver protecting effects and preparation as well as application thereof. The composition is prepared from active ingredients which mainly have the sobering and liver protecting effects and auxiliary materials, wherein the composition of the active ingredients comprise the following components in percentage by weight based on total weight of the active ingredients: 3-10 percent of sesamin, 0.05-5 percent of schisandrin, 10-45 percent of hovenia dulcis thumb extract, 10-45 percent of kudzu vine flower extract, 10-45 percent of nutgrass galingale rhizome extract, 0-0.02 percent of vitamin B12 and 1-10 percent of vitamin E acetate. The invention also relates to application of the composition to preparation of health care foods for preventing and/or treating acute alcoholism, health care foods for treating chronic alcoholic liver damage and health care foods for treating nonalcoholic fatty liver. The composition has the advantages of good synergistic reaction among the components, obvious curative effect, readily available raw materials, easiness in preparation and relatively low cost.

The invention relates to application of a traditional Chinese medicine composition in preparing a medicine capable of treating chronic alcoholic steatohepatitis. The traditional Chinese medicine composition is prepared from the following ingredients in parts by weight: 5-15 parts of radix rhei, 5-15 parts of semen persicae and 3-9 parts of eupolyphaga seu steleophaga. The traditional Chinese medicine composition is prepared according to the following method: independently smashing all raw materials, independently extracting by ethyl alcohol of which the volume concentration is 10-30% for 1-3 times, collecting and combining extracting solutions, and recovering the ethyl alcohol to obtain the traditional Chinese medicine composition. A decoction for discharging blood clots is used for treating the chronic alcoholic steatohepatitis, a good curative effect is obtained, the application range of the decoction for discharging blood clots is enlarged, and a new thought and a new method are provided for clinically treating the chronic alcoholic steatohepatitis.

The invention discloses a composition capable of protecting the liver with chronic alcoholic liver damage. The composition comprises, by weight, 1-5 parts of Penthorum chinense Pursh extract, 0.5-1 part of oligochitosan, 1-2 parts of cordyceps polysaccharide and 1-2 parts of dextrin. A preparation method of the composition includes: separating the Penthorum chinense Pursh extract through macroporous resin, respectively using 1% sodium hydroxide and 95% ethanol for extracting, concentrating, then absorbing with the macroporous resin, respectively using deionized water, 20% ethanol and 40% ethanol to wash impurities absorbed in the resin, eluting with 80% ethanol, and then performing vacuum concentrating; mixing the Penthorum chinense Pursh extract concentrated solution with the oligochitosan, cordyceps polysaccharide and dextrin according to the weight to obtain slurry, spray drying to prepare into powder, using a fluidized bed method to prepare into particles, and drying to obtain granules. The granules can protect the liver of a rat with the chronic alcoholic liver damage.

A medicine in the form of oral liquid, instant particles, tablet, or capsule for treating acute or chronic alcoholic liver damage contains bitter pattra fruit, pueraria flower, VB6, ginsenoside, active substance and one or more medicinal carrier. It is prepared through crushing bitter pattra fruit and pueraria flower, mixing, immersing in water, heating for 30-60 min, filtering, decocting the dregs, filtering, collecting filtrate, concentrating, vacuum drying, and mixing with VB6 and ginsenoside.

The invention belongs to the technical field of medicine, relates to a traditional Chinese medicine composition, and in particular relates to a traditional Chinese medicine composition for treating chronic alcoholic toxic liver disease and a preparation method thereof. Aiming at the current technical defects of lack of comprehensive and effective treatment on the chronic alcoholic toxic liver disease, easiness in relapse of chemical treatment, and inconstant curative effect, the invention provides the traditional Chinese medicine composition for treating chronic alcoholic toxic liver disease. The traditional Chinese medicine composition comprises the following components: 10 parts of rhizoma alismatis, 15 parts of Fourstamen Stephania root, 6 parts of herba artemisiae, 10 parts of fleece-flower root, 10 parts of rhizoma ligustici wallichii, 6 parts of angelica, 20 parts of hovenia dulcis, 20 parts of Chinese gall, 10 parts of radix bupleuri, 12 parts of rhizoma polygonati, 15 parts of Scutellaria baicalensis, 30 parts of Lycium barbarum L., 6 parts of Poria cocos, and 10 parts of liquorice. The traditional Chinese medicine composition has a very good treatment effect in the treatment of chronic alcoholic toxic liver disease, and has significant clinical promotion value.

Methods are provided for inhibiting replication of an RNA virus in a cell infected with the virus, wherein the cell is characterized as having been or concurrently being exposed to a physiologically relevant concentration of a compound selected from ethanol, acetate, isopropanol, acetaldehyde or acetone, comprising contacting the cell with an effective amount of one or more of a HMG-CoA reductase inhibitor, a fatty acid biosynthesis inhibitor, thyroxine, or an agent promoting clearance of the compound from a cell. Also provided are methods to treat a subject having one or more cells characterized as having a physiological concentration of ethanol, acetate, isopropanol, acetaldehyde or acetone, in particular subjects that suffer chronic alcoholics, diabetes or starvation.

The invention provides application of ginsenoside Rc in preparation of a medicine for treating alcoholic fatty liver. Researches show that ginsenoside Rc can effectively inhibit liver injury, lipid accumulation, oxidative stress reaction and inflammatory reaction, so that acute/chronic alcoholic fatty liver is effectively treated, and a new material source is provided for the medicine for treating the alcoholic fatty liver.

The invention discloses application of matteuccia struthiopteris total triterpenes to protection of chronic alcoholic liver damage and belongs to the technical field of biomedicine. Modeling is performed by adopting a dose incremental drinking method, and a chronic liver damage process induced by alcohol of human is simulated. Matteuccia struthiopteris total triterpenes can inhibit GOT and GPT to a certain extent, and an inhibition action is in direct proportion to dosage of administration. Purified matteuccia struthiopteris total triterpenes has higher in-vivo anti-oxidation capability, and a live protection mechanism is that the damage of alcohol to the liver is effectively relieved by enhancing the anti-oxidation capability of the body and effectively removing harmful free radicals. In the purified matteuccia struthiopteris total triterpenes, high dose can effectively relieve oxidated damage caused by factors such as lipid peroxidation in the liver and attack of the free radicals, degree of liver cell enlargement, necrosis and fatty degeneration is reduced, normal metabolism and physiological functions of the cells are regulated, and the effect thereof is superior to that of positive control medicine bifendate in a certain range, which shows that matteuccia struthiopteris total triterpenes has a certain protection action against chronic alcoholic liver damage.