11 results about "Chronic alcoholic" patented technology

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition with an effect of preventing and treating alcoholic liver injury as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines: radix puerariae, turmeric, ginseng, hovenia dulcis thunb, white hyacinth bean, raw oyster shell, poria cocos, raw hawthorn, biond magnolia flower, juncus effuses and albizia flower. The traditional Chinese medicine composition has the effects of soothing liver and harmonizing stomach, dispelling alcohol effect and enlivening spleen, and reinforcing qi and nourishing blood. Experimental results show that the traditional Chinese medicine composition has a good treatment effect on acute alcoholic liver injury and chronic alcoholic fatty liver, and can effectively improve the symptoms of chest rib swelling pain, reduced appetite, anorexia, abdominal distension, hiccup, belching, borborygmus and qi and loose stool caused by liver-stomach disharmony and spleen deficiency and dampness of alcoholic liver injury patients; therefore, the method has good development and utilization prospects.

Pharmacological experiment results show that in a chronic alcoholic intestinal injury model, total lignans of schisandra chinensis can reduce histological injury of intestinal tracts of mice, relieve oxidative injury of small intestines, improve tight connection of the intestinal tracts through a RhoA / ROCK1-MLCK-MLC pathway, improve the intestinal tracts and improve the intestinal tracts, so that the total lignans of schisandra chinensis can be used for preventing and treating chronic alcoholic intestinal injury. The composition can improve intestinal wall villus integrity, reduce intestinal permeability and regulate intestinal flora disorder, so that alcoholic intestinal injury is improved.

The invention discloses a polysaccharide composition for treating chronic alcoholic liver injury and application thereof, and belongs to the field of biological medicine. The polysaccharide composition is prepared by crushing phellinus linteus linteus, bolete, morchella and cordyceps militaris, mixing the crushed materials according to a mass ratio of 4: 2: 2: 2, performing water ultrasonic extraction, and performing hot water extraction. The polysaccharide composition can reduce fat vacuolation and hepatocyte swelling in the liver, inhibit expression of liver function related enzymes such as ALT and AST, improve secretion of blood fat such as total cholesterol, triglyceride and high-density lipoprotein cholesterol and reduce expression of inflammatory factors such as IL-1beta and TNF-alpha in the liver, and the effect of the polysaccharide composition is better than that of single polysaccharide. The polysaccharide composition can relieve liver injury caused by long-term drinking and achieve the effects of dispelling the effects of alcohol and protecting the liver.

The application discloses application of Amomum tsao-ko extract in preparation of medicines for preventing and treating chronic alcoholic liver and intestinal injury, and belongs to the technical field of biotechnology. The extract is applied to prevention and / or treatment of alcoholic liver and intestinal injury and liver-intestinal axis disorder caused by long-term drinking, can reduce contents of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in blood plasma, improve liver and colon tissue pathological injury, repair intestinal mucosal barrier, restore liver tissue mitochondrial function and regulate expression of key factors of liver-intestinal axis; and the Amomum tsao-ko extract can effectively reduce the contents of AST and ALT in blood plasma of alcohol-induced alcoholic liver and intestinal injury model mice at a lower dose, significantly improve liver and intestinal tissue pathological injury, correct liver-intestinal axis function disorder and regulate expression of liver-intestinal axis related factors of liver tissue; the raw material of the application is from a natural product, and is convenient to collect and high in safety.

The invention provides a method and a device for evaluating active substances to relieve chronic alcoholic brain injury. The method comprises the following steps: acquiring gait data of a normal group, a model group and an intervention group; carrying out preprocessing and feature extraction on the collected original gait data; training the gait data of the normal group and the model group, and establishing gait mode models in normal and injured states; and inputting the gait data of the intervention group into the gait mode model for similarity scoring, and evaluating the relieving effect of the active substances on the chronic alcoholic brain injury according to the scoring result. According to the method, the limitation of traditional single parameter comparison is broken through, and the improvement condition of active substances on the gait of the mouse with the chronic alcoholic brain injury is reflected more comprehensively and accurately on the whole; rapid and batch evaluation of various active substances and different doses is realized, and the drug research and development efficiency and the active substance screening efficiency are remarkably improved; the subjectivity in the evaluation process is reduced, and the reliability and comparability of the evaluation result are improved.

The invention discloses a chalcone-lignan glycoside compound separated from hovenia dulcis thunb and an application of the chalcone-lignan glycoside compound in dispelling effects of alcohol and protecting liver. The structure of the aurone-lignan glycoside compound is shown as a formula I or pharmaceutically acceptable salt of the aurone-lignan glycoside compound. The chalcone-lignan glycoside compound can obviously shorten the sobering time of mice suffering from acute alcoholism, reduce the number of autonomous activities of the mice, reduce the content of MDA in the livers of the mice and improve the activity of ADH, SOD and GSH-Px in the livers of the mice, and has remarkable effects of dispelling the effects of alcohol and protecting the liver. The invention discloses application of the chalcone-lignan glycoside compound in preparation of a medicine for dispelling the effects of alcohol and protecting the liver. The invention discloses an application of the chalcone-lignan glycoside compound in preparation of a medicine for treating acute and chronic alcoholic liver injury, and further discloses an application of the chalcone-lignan glycoside compound in preparation of a medicine for treating acute and chronic alcoholic liver injury.

This invention provides oleanolic acid-modified HG-type pectin nanomicelles, their preparation method, and applications. The preparation method of the HG-type pectin nanomicelles includes: esterifying 3,3'-dithiodipropionic acid and oleanolic acid to obtain SS-OA; esterifying SS-OA and HG-type pectin to obtain oleanolic acid-modified HG-type pectin; dissolving the oleanolic acid-modified HG-type pectin and dispersing it ultrasonically to obtain oleanolic acid-modified HG-type pectin nanomicelles. The oleanolic acid-modified HG-type pectin nanomicelles of this invention combine the functional activities of HG-type pectin and oleanolic acid, as well as the redox responsiveness of 3,3'-dithiodipropionic acid, constructing nanomicelles that respond to ROS generated during alcohol metabolism. They exhibit amphiphilicity and good biocompatibility, and can be used to prepare drugs to alleviate chronic alcoholic liver injury.

The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine composition, a preparation method and application of the traditional Chinese medicine composition in treating chronic alcoholic liver injury, the traditional Chinese medicine composition takes lucid ganoderma and radix puerariae as monarch drugs, ginseng and poria cocos as ministerial drugs and walnut peptide as adjuvant and conductant drugs, and the five drugs are compatible, homologous in food and medicine, moderate in middle-level and mild, and harmonious in five internal organs; the effects of tonifying the spleen, soothing the liver, dispelling the effects of alcohol and eliminating evil are achieved. Experiments and clinical verifications prove that the traditional Chinese medicine composition can reduce the inflammation level of the liver by repairing intestinal mucosal barrier injury and reducing LPS entering blood and the liver, and has a good effect of preventing chronic alcoholic hepatitis. Moreover, the traditional Chinese medicine composition disclosed by the invention is simple to prepare, non-toxic and harmless, high in nutritional value and free of severe stimulation and harm to the body. The important social significance is realized on relieving liver inflammation and preventing and treating occurrence and development of liver diseases.

The invention belongs to the technical field of biological medicine, and particularly relates to application of human mesenchymal stem cells in preparation of a medicine for treating CAED and application of a pharmaceutical composition in preparation of a medicine for treating erectile dysfunction, the pharmaceutical composition comprises HucMSCs and a phosphodiesterase 5 inhibitor, the phosphodiesterase 5 inhibitor is prepared from any one or more of sildenafil, tadalafil, vardenafil and avanafil. Researches prove that single HucMSCs and HucMSCs combined with a PDE5 inhibitor can treat chronic alcoholic erectile dysfunction and solve the problems of cavernous endothelium and smooth muscle structural injury, cavernous fibrosis, hormone disorder, oxidative stress injury, intestinal flora disorder, inflammation and / or cavernous cell apoptosis and the like caused by the chronic alcoholic erectile dysfunction. And the HucMSCs are combined with the PDE5 inhibitor to achieve a synergistic effect, so that the treatment effect is better.

This application relates to the field of pharmaceutical use technology, disclosing the application of a pharmaceutical composition in the preparation of drugs for the prevention or treatment of chronic alcoholic brain injury, developing a new use for Tongrentang Niuhuang Qingxin Pills, providing new therapeutic drugs and methods for the intervention and treatment of chronic alcoholic brain injury, thereby providing technical support for the rational use of drugs. This application demonstrates the therapeutic effect of Tongrentang Niuhuang Qingxin Pills on alcoholic brain injury through experiments on model rats, including the detection of learning and memory abilities, balance ability indicators, pathological changes in brain tissue, and S100-β in cerebrospinal fluid.

The invention belongs to the technical field of medicines, and particularly relates to a preparation method and application of oral inulin gel. The oral gel is prepared on the basis of prebiotic inulin capable of adjusting intestinal flora, the effect of repairing intestinal mucosa can be achieved, and the purpose of effectively treating the alcoholic liver disease is achieved. The gel provided by the invention is stable in structure and good in rheological property; in-vivo experiments show that the traditional Chinese medicine can effectively relieve chronic alcoholic liver diseases. The preparation process is simple, the stability is good, the biocompatibility is good, and the preparation method has a good application prospect.