7 results about "Chronic alcoholic" patented technology

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition with an effect of preventing and treating alcoholic liver injury as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines: radix puerariae, turmeric, ginseng, hovenia dulcis thunb, white hyacinth bean, raw oyster shell, poria cocos, raw hawthorn, biond magnolia flower, juncus effuses and albizia flower. The traditional Chinese medicine composition has the effects of soothing liver and harmonizing stomach, dispelling alcohol effect and enlivening spleen, and reinforcing qi and nourishing blood. Experimental results show that the traditional Chinese medicine composition has a good treatment effect on acute alcoholic liver injury and chronic alcoholic fatty liver, and can effectively improve the symptoms of chest rib swelling pain, reduced appetite, anorexia, abdominal distension, hiccup, belching, borborygmus and qi and loose stool caused by liver-stomach disharmony and spleen deficiency and dampness of alcoholic liver injury patients; therefore, the method has good development and utilization prospects.

The invention discloses a polysaccharide composition for treating chronic alcoholic liver injury and application thereof, and belongs to the field of biological medicine. The polysaccharide composition is prepared by crushing phellinus linteus linteus, bolete, morchella and cordyceps militaris, mixing the crushed materials according to a mass ratio of 4: 2: 2: 2, performing water ultrasonic extraction, and performing hot water extraction. The polysaccharide composition can reduce fat vacuolation and hepatocyte swelling in the liver, inhibit expression of liver function related enzymes such as ALT and AST, improve secretion of blood fat such as total cholesterol, triglyceride and high-density lipoprotein cholesterol and reduce expression of inflammatory factors such as IL-1beta and TNF-alpha in the liver, and the effect of the polysaccharide composition is better than that of single polysaccharide. The polysaccharide composition can relieve liver injury caused by long-term drinking and achieve the effects of dispelling the effects of alcohol and protecting the liver.

The application discloses application of Amomum tsao-ko extract in preparation of medicines for preventing and treating chronic alcoholic liver and intestinal injury, and belongs to the technical field of biotechnology. The extract is applied to prevention and / or treatment of alcoholic liver and intestinal injury and liver-intestinal axis disorder caused by long-term drinking, can reduce contents of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in blood plasma, improve liver and colon tissue pathological injury, repair intestinal mucosal barrier, restore liver tissue mitochondrial function and regulate expression of key factors of liver-intestinal axis; and the Amomum tsao-ko extract can effectively reduce the contents of AST and ALT in blood plasma of alcohol-induced alcoholic liver and intestinal injury model mice at a lower dose, significantly improve liver and intestinal tissue pathological injury, correct liver-intestinal axis function disorder and regulate expression of liver-intestinal axis related factors of liver tissue; the raw material of the application is from a natural product, and is convenient to collect and high in safety.

The invention provides a method and a device for evaluating active substances to relieve chronic alcoholic brain injury. The method comprises the following steps: acquiring gait data of a normal group, a model group and an intervention group; carrying out preprocessing and feature extraction on the collected original gait data; training the gait data of the normal group and the model group, and establishing gait mode models in normal and injured states; and inputting the gait data of the intervention group into the gait mode model for similarity scoring, and evaluating the relieving effect of the active substances on the chronic alcoholic brain injury according to the scoring result. According to the method, the limitation of traditional single parameter comparison is broken through, and the improvement condition of active substances on the gait of the mouse with the chronic alcoholic brain injury is reflected more comprehensively and accurately on the whole; rapid and batch evaluation of various active substances and different doses is realized, and the drug research and development efficiency and the active substance screening efficiency are remarkably improved; the subjectivity in the evaluation process is reduced, and the reliability and comparability of the evaluation result are improved.

The invention discloses a chalcone-lignan glycoside compound separated from hovenia dulcis thunb and an application of the chalcone-lignan glycoside compound in dispelling effects of alcohol and protecting liver. The structure of the aurone-lignan glycoside compound is shown as a formula I or pharmaceutically acceptable salt of the aurone-lignan glycoside compound. The chalcone-lignan glycoside compound can obviously shorten the sobering time of mice suffering from acute alcoholism, reduce the number of autonomous activities of the mice, reduce the content of MDA in the livers of the mice and improve the activity of ADH, SOD and GSH-Px in the livers of the mice, and has remarkable effects of dispelling the effects of alcohol and protecting the liver. The invention discloses application of the chalcone-lignan glycoside compound in preparation of a medicine for dispelling the effects of alcohol and protecting the liver. The invention discloses an application of the chalcone-lignan glycoside compound in preparation of a medicine for treating acute and chronic alcoholic liver injury, and further discloses an application of the chalcone-lignan glycoside compound in preparation of a medicine for treating acute and chronic alcoholic liver injury.

This invention provides oleanolic acid-modified HG-type pectin nanomicelles, their preparation method, and applications. The preparation method of the HG-type pectin nanomicelles includes: esterifying 3,3'-dithiodipropionic acid and oleanolic acid to obtain SS-OA; esterifying SS-OA and HG-type pectin to obtain oleanolic acid-modified HG-type pectin; dissolving the oleanolic acid-modified HG-type pectin and dispersing it ultrasonically to obtain oleanolic acid-modified HG-type pectin nanomicelles. The oleanolic acid-modified HG-type pectin nanomicelles of this invention combine the functional activities of HG-type pectin and oleanolic acid, as well as the redox responsiveness of 3,3'-dithiodipropionic acid, constructing nanomicelles that respond to ROS generated during alcohol metabolism. They exhibit amphiphilicity and good biocompatibility, and can be used to prepare drugs to alleviate chronic alcoholic liver injury.

This application relates to the field of pharmaceutical use technology, disclosing the application of a pharmaceutical composition in the preparation of drugs for the prevention or treatment of chronic alcoholic brain injury, developing a new use for Tongrentang Niuhuang Qingxin Pills, providing new therapeutic drugs and methods for the intervention and treatment of chronic alcoholic brain injury, thereby providing technical support for the rational use of drugs. This application demonstrates the therapeutic effect of Tongrentang Niuhuang Qingxin Pills on alcoholic brain injury through experiments on model rats, including the detection of learning and memory abilities, balance ability indicators, pathological changes in brain tissue, and S100-β in cerebrospinal fluid.