The invention belongs to the field of food processing, and particularly relates to a sober-up beverage and a preparation method thereof. The sober-up beverage is prepared from semen dolichoris album, hyacinth-bean flower, kudzu root, wrinkled gianthyssop, sea buckthorn, fresh reed root, hawthorn, perilla, amomum fruit, honey and white sugar. The beverage is based on the traditional Chinese medicine theories; and multiple medicinal and edible key Chinese herbal medicines are selected and scientifically matched, and are subjected to scientific extraction and seasoning to obtain the beverage. The beverage has the effects of soothing the liver, regulating the flow of qi, strengthening the middle-jiao, invigorating qi, reinforcing spleen to promote digestion and the like, and is capable of accelerating alcohol metabolism, effectively protecting the livers, and effectively eliminating the symptoms of thirst, bitter taste, gasterectasis, poor appetite and the like after people drink alcohol. The beverage has special effects on the chronic poisoning symptom caused by long-term excessive alcohol consumption, and can relieve the phenomenon of acute alcoholism.