19 results about "Acute alcoholism" patented technology

The application discloses a high-activity UGT1A1 enzyme based on tree shrew and a feed composition for enhancing alcohol metabolism. The catalytic efficiency of the recombinant tree shrew UGT1A1 enzyme on ethanol is significantly higher than that of human isozyme. The core of the application is to provide a complex feed system containing the enzyme, which solves the key bottleneck of poor stability and low delivery efficiency of exogenous enzymes in application through the synergistic effect of enzyme stabilizers, cell penetration enhancers, enteric coatings and coenzyme supply agents. Animal experiments show that the composition can safely and effectively accelerate in vivo alcohol elimination and reduce blood ethanol concentration, and can be used for developing alcoholism products, acute alcoholism treatment drugs and alcoholic liver disease prevention preparations.

A Limosilactobacillus fermentum strain capable of alleviating a hangover and the use thereof. The strain is at least one strain of Limosilactobacillus fermentum ibiome020, Limosilactobacillus fermentum ibiome021 and Limosilactobacillus fermentum ibiome022 respectively deposited with deposit numbers of CCTCC NO: M 2024188, CCTCC NO: M 2024222 and CCTCC NO: M 2024189. The Limosilactobacillus fermentum is a natural bacterium derived from the intestine of a healthy human and has high safety; can alleviate chronic / acute alcoholism, alcoholic intestinal damage or alcoholic liver damage; can accelerate the metabolism of ethanol and / or acetaldehyde, and delay the onset of intoxication; can shorten the sobering-up time; can reduce the mortality caused by drinking alcohol; can reduce the liver index; can lower the level of AST and / or ALT in serum; can alleviate discomfort caused by ethanol and / or acetaldehyde, and mitigate symptoms such as dizziness, headache, nausea and vomiting, and hangover after drinking alcohol; can ameliorate oxidative stress caused by alcohol, and increase the level of GSH in the liver; and also has excellent resistance to gastrointestinal fluid and bile salt, and can adapt to the complex environment within the body.

The invention relates to a composition for preventing and relieving acute drunkenness. The composition is prepared from the following raw materials in parts by weight: 30 parts of flos puerariae, 10 parts of rhizoma cimicifugae, 10 parts of sedum sarmentosum, 15 parts of rhizoma alismatis, 15 parts of bighead atractylodes rhizome, 30 parts of poria cocos, 15 parts of hairyvein agrimony, 15 parts of galangal and 30 parts of lalang grass rhizome. The composition provided by the invention is a multi-target and multi-path protection process for treating acute alcoholism, and relates to anti-inflammation, anti-allergy, promotion of protein synthesis, immunosuppression, anti-shock, regulation of cholesterol of blood fat, and participation in alcohol decomposition and metabolic pathways; the traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition can be used for preventing acute drunkenness and reducing alcohol metabolism hazards, including hyperlipidemia, dementia, hypercholesterolemia, fatty liver, cognitive impairment, cardiovascular and cerebrovascular diseases and the like, after drunkenness can be reduced, in addition, the traditional Chinese medicine composition can also protect cardiovascular, nerves and bones after drunkenness, regulate immunity and enhance immunity after drunkenness can also be realized, and the traditional Chinese medicine composition can also be used for preventing drunkenness and preventing drunkenness from suffering from the influence on transcription factors such as SP1, ESR1, RELA (P65), NF-kappa b1, STAT3 and the like.

The invention belongs to the field of life health and health products, and discloses a preparation method and application of medicinal and edible oral liquid with effects of dispelling effects of alcohol and protecting liver. The raw material formula comprises a ginseng extract, hovenia dulcis thunb, radix puerariae, roselle, rhizoma polygonati, gastrodia elata, schisandra chinensis and a dihydroquercetin extract, the hovenia dulcis thunb, the radix puerariae, the roselle, the rhizoma polygonati, the gastrodia elata and the schisandra chinensis are taken in proportion, water reflux extraction and filtration are performed, extracting solutions are combined, the ginseng extract and the dihydroquercetin extract are added, and filling and sterilization are performed to obtain the traditional Chinese medicine composition. Functions of the raw materials are fully utilized, the oral liquid is capable of relieving drunkenness, enlivening spleen, protecting liver and benefiting gallbladder, and behavioral observation of a mouse acute alcoholism experiment proves that the oral liquid can delay drunkenness, accelerate sobering up and relieve swelling pain of brain and liver, drunkenness and the like caused by excessive drinking. Enzymatic index detection of a mouse acute alcoholism experiment proves that the oral liquid can quickly improve the alcohol decomposition capability of the liver after being taken, delay the absorption of alcohol in the body and achieve the effects of dispelling the effects of alcohol and relieving drunkenness.

The invention relates to the technical field of microorganisms, and discloses a plant lactobacillus XJSN202504 and application thereof in acute alcoholism, the plant lactobacillus XJSN202504 is preserved in China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC NO.34746, and the preservation time is June 3, 2025. The invention further discloses a preparation method of the plant lactobacillus XJSN202504. The lactobacillus plantarum XJSN202504 disclosed by the invention can be used for improving liver injury related indexes in serum and expression of inflammation related genes, and also can be used for adjusting the activity of antioxidant enzymes in the liver and relieving alcohol-induced oxidative stress injury; moreover, gastric mucosa, small intestine and colon injuries caused by a large amount of alcohol can be effectively prevented, the anti-inflammatory activity and the antioxidant activity are better, the anti-alcohol function can be achieved through gastrointestinal tracts, and the effects of protecting liver and digestive tract mucosa are achieved.

The invention relates to an RNA (Ribonucleic Acid) medicine, which is used for coding ALDH2 (Alcohol Dehydrogenase 2) protein, can efficiently express ALDH2 and quickly and durably reduce the content of acetaldehyde in a body, and is used for treating acute alcoholism caused by acetaldehyde accumulation as well as diseases such as metabolism, cardiovascular diseases, neurological diseases, malignant tumors and the like.

The invention discloses a phosphodiesterase 9A inhibitor for treating alcohol addiction and acute alcoholism, relates to the technical field of medicines, and has the technical key point that the inhibitor is BI-409306. The BI-409306 can influence the drinking behavior of a mouse with alcohol addiction by adjusting synaptic plasticity and intervene the formation of addiction. In addition, the BI can also reduce acute alcohol toxicity injury by recovering the GPX4 level and reducing inflammatory factors. The invention not only lays a research foundation for exploring the effect and mechanism of BI in alcohol addiction in the future, but also provides a new target and thought for clinically treating alcohol addiction.

The application belongs to the field of pharmacy, discloses a fused ring morphine derivative and a preparation method and application thereof, and relates to N-cyclopropylmethyl-4'-substituted aminonalepotem series derivatives with formula (I) and pharmaceutically acceptable salts. The derivative with formula (I) is prepared by reacting thebaine with a substituted phenyl vinyl ketone reagent and through a series of conversion methods. Among them, N-cyclopropylmethyl-(4'-benzoyl amino) nalepotem (SLL-1062) is a typical high selectivity mu opioid receptor antagonist, and can be applied to the research and development in the fields of diagnosis and treatment of opioid and other narcotic analgesic dependence, opioid drug-induced intestinal dysfunction, sedative hypnotics and acute alcohol poisoning, opioid and other narcotic analgesic poisoning and the like.

Provided herein are methods for treating acute alcohol toxicity using an agonist for a Fibroblast Growth Factor Receptor (FGFR) andβKlotho complex such as Fibroblast Growth Factor 21 (GFF21). Also provided are compositions and kits comprising these agonists (e.g., FGF21 (for administration to a subject in need.

This invention discloses an orally disintegrating film formulation of BPC-157 sodium salt for treating acute alcohol poisoning and its preparation method. It relates to the field of acute alcohol poisoning treatment technology. The orally disintegrating film formulation comprises, by weight percentage: 0.1-5% BPC-157 sodium salt, 40-70% film-forming material, 5-15% plasticizer, 0.1-15% disintegrant, 0.1-15% sweetener, 0.1-10% salivary stimulant, and 1-5% other excipients. This invention prepares an orally disintegrating film formulation of BPC-157 sodium salt, utilizing its rapid dissolution characteristics and the pharmacological effects of BPC-157, providing a new option for treating acute alcohol poisoning. This formulation has advantages such as rapid onset of action, high bioavailability, and few side effects, and is expected to become an effective drug for treating acute alcohol poisoning.

The present application relates to a kind of compositions for preventing and relieving acute drunkenness, which is prepared from the following raw materials by weight: 30 parts of Gegen, 10 parts of Chengma, 10 parts of Zhupencao, 15 parts of Zexie, 15 parts of Baishu, 30 parts of Fuling, 15 parts of Xianhecao, 15 parts of Gaoliangjiang and 30 parts of Baimaogen.The composition provided by the present application is a multi-target and multi-path protective process for treating acute alcoholism, involving anti-inflammatory, anti-allergic, promoting protein synthesis, immunosuppression, anti-shock, regulating blood lipids and cholesterol, participating in alcohol decomposition and metabolic pathways; affecting transcription factors such as SP1, ESR1, RELA (P65), NF-κb1 and STAT3, which can not only prevent acute drunkenness, but also reduce the harm of alcohol metabolism after drunkenness, including hyperlipidemia, dementia, hypercholesterolemia, fatty liver, cognitive impairment, cardiovascular and cerebrovascular diseases, etc. In addition, it can also protect the cardiovascular, nervous and skeletal systems after drunkenness, regulate immunity and enhance the immune capacity after drunkenness.

The invention discloses a chalcone-lignan glycoside compound separated from hovenia dulcis thunb and an application of the chalcone-lignan glycoside compound in dispelling effects of alcohol and protecting liver. The structure of the aurone-lignan glycoside compound is shown as a formula I or pharmaceutically acceptable salt of the aurone-lignan glycoside compound. The chalcone-lignan glycoside compound can obviously shorten the sobering time of mice suffering from acute alcoholism, reduce the number of autonomous activities of the mice, reduce the content of MDA in the livers of the mice and improve the activity of ADH, SOD and GSH-Px in the livers of the mice, and has remarkable effects of dispelling the effects of alcohol and protecting the liver. The invention discloses application of the chalcone-lignan glycoside compound in preparation of a medicine for dispelling the effects of alcohol and protecting the liver. The invention discloses an application of the chalcone-lignan glycoside compound in preparation of a medicine for treating acute and chronic alcoholic liver injury, and further discloses an application of the chalcone-lignan glycoside compound in preparation of a medicine for treating acute and chronic alcoholic liver injury.

This invention provides a compound, its preparation method, a pharmaceutical composition, and its applications, relating to the field of pharmaceutical technology. The compound provided by this invention has the structure shown in Formula I. This compound can effectively relieve acute alcohol poisoning and protect the liver from damage. In vitro cell experiments show that this compound can accelerate the excretion of ethanol, acetaldehyde, and their metabolites in vivo, protect hepatocytes from acetaldehyde-induced lipid peroxidation, and prevent acetaldehyde-induced glutathione reduction. In a mouse model of acute alcohol poisoning, this compound can significantly delay the onset of intoxication and significantly accelerate the sobering-up time. Furthermore, the compound provided by this invention has low toxicity and good drug-like properties. This invention provides a method for preparing the compound with the structure shown in Formula I, which is simple to synthesize and has a high yield.

The invention belongs to the technical field of biological medicines, and particularly relates to application of methylophiopogonanone B in preparation of a medicine for preventing and treating acute alcoholism. The methylophiopogon flavanone B can relieve clinical symptoms or physiological abnormalities of acute alcoholism, shorten sobering time and sleep time of experimental animals suffering from acute alcoholism, reduce liver indexes, maintain normal morphological structures of liver tissues and cells, reduce levels of glutamic-pyruvic transaminase and glutamic oxalacetic transaminase in serum and improve the curative effect of acute alcoholism. The composition has the effects of reducing serum total cholesterol and triglyceride levels, increasing the activity of superoxide dismutase and glutathione peroxidase, increasing the content of reduced glutathione, reducing the content of malondialdehyde, improving the functions of organs such as liver, kidney, stomach and the like of acute alcoholism animals, regulating proteome expression of acute alcoholism mice, and treating acute alcoholism. The composition has the effect of preventing and treating acute alcoholism.

The application belongs to the technical field of hangover food after acute alcoholism, and discloses application of fermented sea cucumber liquid rich in acidic polysaccharide in hangover food. The hangover food is fermented sea cucumber liquid rich in acidic polysaccharide; the fermented sea cucumber liquid rich in acidic polysaccharide comprises 35% sea cucumber homogenate liquid, 7.5 g / L glucose and 4% probiotic strains. The fermented sea cucumber liquid rich in acidic polysaccharide activates ethanol dehydrogenase and acetaldehyde dehydrogenase activity, reduces blood alcohol concentration after 3 hours of drinking, prolongs the average latency time, shortens the average duration time and improves the tolerance to acute alcoholism; improves liver antioxidant enzyme activity and slows down liver cell damage caused by continuous intake of high-dose alcohol. The fermented sea cucumber liquid rich in acidic polysaccharide can be applied to the prevention of acute alcoholism and hangover health care functional food.

The invention relates to the technical field of traditional Chinese medicine compositions, and particularly discloses a traditional Chinese medicine composition for dispelling effects of alcohol and protecting liver, a preparation method and application. The composition is prepared from the following raw materials in parts by weight: 20 to 60 parts of flos puerariae, 12 to 48 parts of semen hoveniae and 5 to 15 parts of fructus schizandrae. The preparation method comprises the following steps: crushing the raw materials, extracting with water, concentrating and drying to obtain an extract A; or further centrifuging, dialyzing and filtering to obtain an extract B; the composition is suitable for preparing medicines for treating acute alcoholism and alcoholic liver injury, or health-care products / foods with functions of dispelling effects of alcohol, protecting liver and protecting gastric mucosa. The composition is simple (three medicinal materials), contains medicinal and edible components (hovenia dulcis thunb and schisandra chinensis), and is high in safety; an extract A (conventional extraction) and an extract B (high-purity active components) are respectively obtained through a double-preparation process; the traditional Chinese medicine composition has the effects of dispelling effects of alcohol, promoting awakening, repairing liver injury, protecting gastric mucosa and promoting alcohol metabolism.

Provided herein is a method for treating acute alcoholism using agonists of fibroblast growth factor receptor (FGFR) and beta-klotho complex, such as fibroblast growth factor 21 (FGF21).Also provided are compositions and kits that contain these agonists (such as FGF21) for administration to subjects in need thereof.

The invention discloses application of combination of ligustrazine and inosine in preparation of a medicine for dispelling effects of alcohol and protecting liver, and belongs to the technical field of medicine research and development. The ligustrazine and inosine are combined for intervention, so that behavioral characteristic data and serum metabolism indexes of mice suffering from acute alcoholism after drinking can be improved, the oxidative stress level in the bodies of the mice suffering from alcoholic liver injury can be reduced, the conditions of inflammatory response, fat accumulation and the like can be relieved, and dose correlation is achieved. The combined use of ligustrazine and inosine can enhance the phosphorylation level of PI3K and AKT proteins by activating an ESR1 / PI3K / AKT signal channel and an Nrf2 / HO-1 signal channel, reverse the low expression of inflammatory factors IL-10 and the high expression of TNF-alpha and IL-6, and relieve the damage of alcohol to the liver of a mouse. Based on the discovery, the combination of ligustrazine and inosine has the effects of dispelling the effects of alcohol and protecting the liver, and a new choice is provided for research, development and preparation of the medicines for dispelling the effects of alcohol and protecting the liver.

The invention belongs to the technical field of jujube bud reutilization, and provides application of a jujube bud tea extract in preparation of a product for improving alcoholic liver injury. The alcoholic liver injury is acute alcoholism liver injury. The jujube bud tea extract is a jujube bud tea water extract. The preparation method of the jujube bud tea water extract comprises the following steps: adding 10 times by weight of water into jujube bud tea, carrying out reflux extraction at 100 DEG C for 1 hour, filtering, adding 8 times by weight of water into filter residues, carrying out reflux extraction at 100 DEG C for 45 minutes, filtering, combining two filtrates, and concentrating into 0.3 g.mL <-1 > water decoction according to the crude drug amount. The prepared jujube bud tea water extract has a certain protection effect on the liver of a drunken rat, and can reduce the injury degree of the liver; the jujube bud tea extract has a certain improvement effect on liver injury of rats suffering from acute alcoholism.