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314results about How to "Lower level" patented technology

Patch antenna with wire radiation elements for high-precision GNSS applications

A right-hand circularly-polarized patch antenna comprising a ground plane and a patch connected to each other with one or more wires for which the wire shape and location of the end points are selected such that they do not cause an antenna mismatch, and the electrical current carried in the wires produces an extra electromagnetic field subtracted from the patch field in the nadir direction.
Owner:TOPCON POSITIONING SYSTEMS INC

Viable bacterium preparation of lactobacillus paracasei strain as well as preparation method and application of viable bacterium preparation

The invention relates to the technical field of microorganisms, in particular to a viable bacterium preparation of a lactobacillus paracasei strain as well as a preparation method and application of the viable bacterium preparation. The viable bacterium preparation comprises a lactobacillus paracasei strain and auxiliary materials, and the preservation number of the lactobacillus paracasei strain is CGMCC (China General Microbiological Culture Collection Center) No.27974. The viable bacterium preparation can inhibit the growth of streptococcus mutans, reduce the formation of a dental plaque biofilm caused by the streptococcus mutans, reduce the content of a mature dental plaque biofilm, inhibit the level of water-insoluble exopolysaccharides generated by the streptococcus mutans, reduce the expression quantity of cariogenic genes gtfB, gtfC, gtfD, ftf and LuxS of the streptococcus mutans, improve the cariogenic activity of the streptococcus mutans and improve the cariogenic activity of the streptococcus mutans. The adhesion rate of streptococcus mutans on a hydroxyapatite tooth model is reduced, and a beneficial in-vitro probiotic function is achieved.
Owner:COREE CO LTD

Application of RNF130 activator in preparation of medicine for preventing and / or treating ischemic heart disease

The invention discloses application of an RNF130 activator in preparation of a medicine for preventing and / or treating ischemic heart disease, and belongs to the technical field of biological medicine. Research results show that when an RNF130 activator is given in a mouse of a myocardial ischemia reperfusion injury model, the left ventricular ejection fraction and the left ventricular short-axis shortening rate of the mouse can be improved, myocardial tissue pathological injury can be relieved, the protein expression levels of NOX-2, BAX and TNF-alpha are reduced, the myocardial infarction area is reduced, and myocardial cell apoptosis is reduced; therefore, the RNF130 activator has prevention and treatment effects on the myocardial ischemia-reperfusion injury, that is, the RNF130 activator can be used as an effective component of the medicine for preventing or treating diabetes complicated by myocardial ischemia-reperfusion injury, and a new strategy is provided for preparation of the medicine for preventing and treating myocardial ischemia-reperfusion injury.
Owner:JIANGNAN UNIV

Bifidobacterium adolescentis, composition for inhibiting generation and accumulation of lipofuscin, application and cosmetics

The invention belongs to the field of daily chemicals, and discloses a strain of bifidobacterium adolescentis, the classification name of the bifidobacterium adolescentis BF23BA001 is bifidobacterium adolescentis, the preservation number is CGMCC NO.26999, and the strain of bifidobacterium adolescentis BF23BA001 is named as bifidobacterium adolescentis BF23BA001. The preservation date is March 31, 2023, and the preservation unit is China General Microbiological Culture Collection Center (CGMCC); the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. Compared with other commercially available similar bacteria, the strain has unique advantages in the production of small molecule peptides and gamma-aminobutyric acid, has a remarkable anti-wrinkle advantage according to the functional characteristics of the small molecule peptides and gamma-aminobutyric acid, and has a remarkable anti-wrinkle effect through subsequent functional verification. The method is of great significance to further improvement of whitening, brightening, repairing and anti-aging effects of yeast fermentation products. In addition, the invention further discloses a composition for inhibiting generation and accumulation of lipofuscin, application based on the composition and cosmetics.
Owner:GUANGDONG HEJI BIOTECH CO LTD +1

Communication sensing integrated beamforming method and system for suppressing distance-angle sidelobe

The invention provides a communication perception integrated beamforming method and system for suppressing distance-angle side lobes, and the method comprises the steps: enabling a base station to communicate with a plurality of users under a digital beamforming ISAC architecture, and carrying out the detection of an air target in a self-transmitting and self-receiving mode at the same time; determining a sensing channel model and a communication channel model to obtain a communication receiving signal at each user position and a sensing receiving signal scattered back to the base station from the target; calculating to obtain the SINR of each user; a distance-angle-Doppler three-dimensional perception fuzzy function based on a digital beam forming ISAC architecture is obtained; extracting an expression of an integral sidelobe of a distance-angle dimension; according to the communication index, the sensing index and the integral sidelobe value in the preset distance-angle sidelobe area, a beam forming matrix of the ISAC system is designed in a joint optimization mode; auxiliary variables are introduced to convert the problem of optimizing the beam forming matrix into the problem of optimizing a covariance matrix of the beam forming matrix, and a feasible solution of the joint design problem is obtained.
Owner:SHANGHAI JIAOTONG UNIV +2

Lactobacillus mucilaginosus and application thereof in fermentation of sporoderm-broken ganoderma lucidum spore powder

PendingCN119662448Astrong adhesionHigh content of bioactive substancesBiocideAntibacterial agentsBiotechnologyShigella sp
The invention discloses lactobacillus mucilaginosus and application thereof in fermentation of sporoderm-broken ganoderma lucidum spore powder. The preservation number of the lactobacillus mucilaginosus is CGMCC (China General Microbiological Culture Collection Center) No.31453. The strain is separated and screened from vaginal secretions of healthy women at the childbearing age, is not hemolyzed, is sensitive to various common antibiotics and has strong lactic acid production capacity, and fermented supernate of the strain has strong growth inhibition capacity on escherichia coli, pseudomonas aeruginosa, staphylococcus aureus, salmonella typhimurium, shigella dysenteriae and gardnerella vaginalis and can be used for producing lactic acid. The compound has strong adhesion ability, growth inhibition ability and apoptosis promoting effect on human cervical cancer cells. When the strain is used for fermenting wall-broken ganoderma lucidum spore powder, the content of bioactive substances such as amino acids and derivatives thereof, fatty acids and steroids in fermentation liquor can be greatly increased, the strain has an obvious anti-inflammatory effect on DSS-induced mouse colitis, and the inflammatory factor level is remarkably reduced. The strain not only has significant application value in functional food and biological agents, but also opens up a new way for further development of ganoderma spores.
Owner:SICHUAN UNIV

Application of POK erythroid myelogenic factor ZBTB7A in resisting hepatitis B virus

The invention discloses an application of a POK erythroid myelogenic factor ZBTB7A in resisting hepatitis B virus. Experiments prove that the overexpression of the ZBTB7A can significantly reduce the level of secreted HBV-related virus protein and significantly inhibit HBV transcription and replication, and a new potential target is provided for treatment of hepatitis B. The research prompts that the ZBTB7A can be used as a novel HBV host limiting factor, lays a foundation for developing novel antiviral drugs, provides more effective treatment schemes for clinical treatment, and has wide application prospects and market potential.
Owner:CHONGQING MEDICAL UNIVERSITY

PCB structure for improving clock signal backflow path

The utility model discloses a PCB structure for improving a clock signal backflow path, which comprises a PCB body, the PCB body comprises a surface wiring layer and a plurality of internal wiring layers which are arranged from top to bottom, the surface wiring layer is provided with a clock signal layer changing hole and GND backflow holes distributed at two sides of the clock signal layer changing hole, and the GND backflow holes are communicated with the internal wiring layers. The center distance between the GND backflow hole and the clock signal layer change hole is smaller than or equal to 3 mm. According to the design, the backflow path of the clock signal is obviously optimized, so that the stable backflow path of the clock signal in the transmission process can be ensured, attenuation and distortion of the clock signal can be reduced, the stability and accuracy of the clock signal can be improved, and the GND backflow hole not only provides the stable backflow path, but also improves the reliability of the clock signal. And electromagnetic radiation generated in the clock signal transmission process is effectively absorbed through the metal grounding property, so that interference to other circuits and systems is reduced.
Owner:CHANGSHA QUANBO ELECTRONIC TECH CO LTD

Whitening nano-emulsion and preparation method thereof

The invention discloses a whitening nano-emulsion and a preparation method thereof, and relates to the technical field of cosmetics and skin care products. The whitening nano-emulsion is prepared from the following components in percentage by weight: 2.0 to 10.0 percent of an emulsifying agent, 4.0 to 10.0 percent of an emollient, 3.0 to 8.0 percent of glycerol, 3.0 to 8.0 percent of butanediol, 0.5 to 3.0 percent of nicotinamide, 1.0 to 3.0 percent of a Soulixian extract, 0.5 to 3.0 percent of ascorbyl tetraisopalmitate, 0.3 to 3.0 percent of hydrogenated lecithin, 0.1 to 2.0 percent of hydroxyethyl piperazine ethanesulfonic acid, 0.1 to 1.0 percent of SymSitive1609, 0.03 to 0.5 percent of a mulberry root extract, 0.03 to 1.0 percent of cerium oxide and the balance of water. The toothpaste is prepared from the following components in percentage by weight: 0.05 to 0.5 percent of tocopheryl acetate, 0.03 to 0.3 percent of stearyl glycyrrhetinic acid ester, 0.01 to 0.1 percent of poly gamma-sodium glutamate, 0.03 to 0.2 percent of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.2 to 1.0 percent of preservative, 0.01 to 0.1 percent of aromatic and the balance of water, wherein the total The prepared whitening nano-emulsion can solve the problems of excessive addition, difficult absorption and instability of active ingredients of cosmetics, can inhibit DPPH free radical activity, hydroxyl free radical activity and tyrosinase activity through the synergistic effect of all the components, achieves the effects of resisting oxidation, whitening, removing freckles, brightening skin and the like, and does not cause damage to the skin.
Owner:广东鼎尖国际生物科技有限公司

Biomarker for early diagnosis of femoral head necrosis and application thereof

The invention discloses a biomarker for early diagnosis of femoral head necrosis and application thereof, and relates to the technical field of biology. The biological marker is a serum mechanical gating cation channel Piezo1. The research finds that after early vascular endothelial cells of femoral head necrosis are damaged, the Piezo1 expression is reduced, so that the Piezo1 in blood is obviously reduced, that is, the serum mechanical gating cation channel Piezo1 can assist MRI to serve as a new index of femoral head necrosis; the monitoring of the level of the serum mechanical gating cation channel Piezo1 provides a new marker for the screening of early femoral head necrosis.
Owner:SHANDONG COLLEGE OF TRADITIONAL CHINESE MEDICINE

Composition for dispelling effects of alcohol and protecting liver and application thereof

The invention relates to the field of food and health care products, and discloses a composition for dispelling effects of alcohol and protecting liver, which comprises 20-100 parts of ampelopsis grossedentata leaf extract; 50 to 200 parts of a radix puerariae extract; 10-50 parts of a semen hoveniae extract; 10-50 parts of a turmeric extract; 10 to 100 parts of a yeast extract; 5-50 parts of a licorice extract; and 5 to 20 parts of pyrroloquinoline quinone disodium salt. The ampelopsis grossedentata leaf extract, the kudzuvine root extract and the hovenia dulcis thunb extract are utilized, alcohol decomposition is promoted, the blood ethanol concentration is reduced, and drunkenness symptoms are relieved. Puerarin improves activity of liver metabolic enzymes, accelerates discharge of ethanol and acetaldehyde, and reduces liver damage. The anti-oxidation effects of dihydromyricetin and PQQ can eliminate alcohol metabolism free radicals and protect liver cells. The components such as puerarin, hovenia dulcis thunb, curcumin and glycyrrhizic acid jointly promote liver cell regeneration, inflammation and oxidative damage are reduced, the levels of ALT and AST in serum are reduced, and liver health is maintained.
Owner:EUGENE EXCELLENCE (TIANJIN) BIOMEDICAL TECH CO LTD

Construction method and application of caenorhabditis elegans inflammation model

The invention discloses a construction method and application of a caenorhabditis elegans inflammation model, belongs to the technical field of model biology, and provides a construction method of a caenorhabditis elegans inflammation model, which comprises the following steps: putting L1-stage caenorhabditis elegans into a lipopolysaccharide solution, and carrying out induced culture to obtain induced cultured caenorhabditis elegans; placing the caenorhabditis elegans in a chromosome system, performing staining culture and centrifugation to obtain dyed caenorhabditis elegans, and placing the dyed caenorhabditis elegans on a culture medium for recovery to obtain the caenorhabditis The surface of the caenorhabditis elegans is provided with a transparent cuticle anatomical structure, the intestinal barrier damage condition is easy to observe after the intestinal tract is dyed by a dye, and the cell proliferation, tissue development and tissue integrity of the caenorhabditis elegans are easy to carry out fluorescence microscope and morphological analysis. A caenorhabditis elegans inflammation model is constructed through lipopolysaccharide induction, and a new experimental animal model is provided for screening anti-inflammatory drugs.
Owner:SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING

Preparation method and application of lactic acid bacteria fermented Chinese chestnut protein postbiotics for improving systemic chronic inflammation

The invention belongs to the technical field of preparation of postbiotics, and discloses a preparation method and application of lactic acid bacteria fermented Chinese chestnut protein postbiotics for improving systemic chronic inflammations, Chinese chestnuts are subjected to shelling, grinding and degreasing treatment, and degreased Chinese chestnut powder is obtained; resuspending the degreased Chinese chestnut powder in distilled water, adjusting the pH value, and stirring; performing solid-liquid separation and magnetic stirring; carrying out solid-liquid separation, resuspending and adjusting the pH value; dialyzing to obtain Chinese chestnut protein powder; mixing with glucose powder, and redissolving in distilled water; and mixing with lactic acid bacteria and carrying out aerobic fermentation to obtain the Chinese chestnut protein metaplasm product. The bioactive peptides contained in the Chinese chestnut protein metaplasm prepared by the method have potential anti-inflammatory activity, can effectively inhibit proinflammatory medium secretion of macrophages and intestinal epithelial cells, and improve glucose and lipid metabolism disorder and intestinal barrier function damage related to chronic inflammation of a body. The bioactive peptide contained in the postbiotic product disclosed by the invention has an anti-inflammatory effect.
Owner:NANKAI UNIV

Application of probiotics Blauria wexlerae in improvement or treatment of children inflammatory bowel disease

The invention discloses an application of probiotics Blauria winteriae in the preparation of a medicine or food for improving or treating the inflammatory bowel disease of children, and relates to the field of medicines or foods for improving or treating the inflammatory bowel disease of children. According to the invention, the probiotic Blauria wexlerae is used as an effective component to be prepared into medically and food acceptable dosage forms, so that the children inflammatory bowel disease can be obviously improved or treated, and the application value of the probiotic is improved.
Owner:XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Preparation method and application of response type NO release anticoagulant hydrogel material

The invention discloses a preparation method and application of a response type NO release anticoagulant hydrogel material. The preparation method comprises the following steps: providing methylacryloylated recombinant collagen; providing methacrylated hyaluronic acid; providing caffeic acid arginine amide modified hyaluronic acid; the response type NO release anticoagulant hydrogel material is obtained by taking methylacryloylated recombinant collagen, methylacryloylated hyaluronic acid and caffeic acid arginine amide modified hyaluronic acid as raw materials. The prepared hydrogel material has the advantages of resisting bacteria, promoting proliferation of endothelial cells, inhibiting proliferation of smooth muscle cells, resisting inflammation, promoting angiogenesis, inhibiting thrombosis and the like, arginine can serve as an endogenous NO donor in blood to release NO molecules, and therefore the effect of promoting vascular endothelial repair is achieved, and the hydrogel material has the advantages of being capable of resisting bacteria, promoting proliferation of endothelial cells, inhibiting proliferation of smooth muscle cells, resisting inflammation, promoting angiogenesis, inhibiting thrombosis and the like. The introduced NO molecules enable the hydrogel material to have good anticoagulant performance, and the hydrogel material is expected to be used for preparing an artificial blood vessel anticoagulant coating.
Owner:NORTHWEST UNIV

Application of atypical retinoid A-7 in preparation of androgen receptor inhibitor and antitumor drug

The invention discloses application of atypical retinoid A-7 in preparation of androgen receptor inhibitors and antitumor drugs, and belongs to the technical field of medicines. It is proved for the first time that AR can be degraded through a CMA pathway, and the atypical retinoid A-7 serving as an AR inhibitor can obviously reduce the AR protein level in prostate cancer cells; in addition, the Atypic retinoids 7 can be used for inhibiting the growth and proliferation capacity of the prostate cancer cells LNCaP; in addition, the invention further provides an anti-tumor medicine composition, the anti-tumor medicine composition comprises the Atypic retinoid-7 and Enzalutamide, and the anti-tumor medicine composition can be used for treating the prostatic cancer and has important clinical significance.
Owner:CHIMEDICAL UNIVERSITY

Lactobacillus paracasei strain as well as fermentation product and application thereof

PendingCN119530077AGood self-gathering abilityInhibition of adhesionCosmetic preparationsAntibacterial agentsBiotechnologyFermentation
The invention relates to the technical field of microorganisms, in particular to a lactobacillus paracasei strain as well as a fermentation product and application thereof. The preservation number of the lactobacillus paracasei strain is CGMCC (China General Microbiological Culture Collection Center) No.27974. The Lactobacillus paracasei can inhibit the growth of Streptococcus mutans, reduce the formation of a dental plaque biofilm caused by Streptococcus mutans, reduce the content of a mature dental plaque biofilm, inhibit the level of water-insoluble exopolysaccharides generated by Streptococcus mutans, and reduce the expression quantity of cariogenic genes gtfB, gtfC, gtfD, ftf and LuxS of Streptococcus mutans, and can be used for fermentation production of fermented milk. And oat milk and other fermentation products.
Owner:COREE CO LTD

Lactobacillus rhamnosus capable of preventing or treating inflammatory bowel disease and promoting digestion and application thereof

The invention relates to the technical field of microorganisms, in particular to lactobacillus rhamnosus capable of preventing or treating inflammatory bowel diseases and promoting digestion and application of the lactobacillus rhamnosus, and belongs to the technical field of biological medicine. The invention provides a strain of lactobacillus rhamnosus R7970, wherein the preservation number of the lactobacillus rhamnosus R7970 is CGMCC (China General Microbiological Culture Collection Center) 22244, and the preservation number of the lactobacillus rhamnosus R7970 is CGMCC 22244. The lactobacillus rhamnosus R7970 can be used for effectively preventing inflammatory enteritis (IBD) and has a prevention effect on intestinal inflammation, and meanwhile, the lactobacillus rhamnosus R7970 can be used for improving the nutrition digestion and absorption functions of intestinal tracts. Therefore, the lactobacillus rhamnosus R7970 can be applied to prevention of IBD, can be used for preparing probiotic preparations, common foods, health foods and biological pharmacy for improving intestinal health, is convenient for industrial production, and has great popularization value.
Owner:内蒙古科拓生物有限公司 +1

Composite probiotic composition for improving allergic rhinitis as well as preparation method and application of composite probiotic composition

The invention provides a compound probiotic composition for improving allergic rhinitis as well as a preparation method and application thereof, and belongs to the technical field of biological preparations. Comprising a composite probiotic liquid, an auxiliary agent, a humectant and a thickening agent, wherein the composite probiotic liquid is composed of a composite bacterium fermentation liquid and probiotic substances, and the composite fermentation liquid is prepared by respectively fermenting saccharomyces boulardii, two bifidobacteria, lactobacillus reuteri, lactobacillus rhamnosus and streptococcus thermophilus. According to the compound probiotic composition, growth of probiotics is promoted through different probiotics, flora balance is adjusted and immunity is improved through mutual cooperation of the different probiotics, rhinitis symptoms are improved, meanwhile, components such as centipeda minima are added to serve as auxiliaries, and the effect of improving rhinitis symptoms is achieved. And the probiotics and the compound probiotics can achieve a synergistic effect to jointly improve the symptoms of the allergic rhinitis.
Owner:胡永刚

Lactobacillus crispatus capable of promoting female genital tract health and delaying genital tract immune aging

The invention discloses lactobacillus crispatus for improving female genital tract microenvironment and immune aging and application of the lactobacillus crispatus, and belongs to the field of probiotics. The probiotic lactobacillus crispatus ProSci-38 disclosed by the invention can be used for effectively improving the symptoms such as pruritus vulvae, causalgia of vagina, abnormal vaginal secretion and the like of patients with vaginitis; mainly through the effect of intestinal tract-vaginal axis, the proportion of lactobacillus is increased, the proportion of harmful bacteria is reduced, the balance of vaginal flora is recovered, and the acidic environment of vagina is maintained; meanwhile, the inflammatory factor level can be reduced, the immune function of the vagina of a patient can be improved, so that the vagina environment is improved, the infection risk is reduced, and the preparation method has a great prospect in preparation of products for relieving and / or treating vaginitis.
Owner:BEIJING SCITOP BIO TECH CO LTD

White peony root extract for treating hyperuricemia, preparation method and application thereof

The present invention belongs to the field of medical technology related to the extraction and application of natural drug components, discloses a white peony extract for treating hyperuricemia, a preparation method thereof and an application thereof, and provides a preparation method of a white peony extract for treating hyperuricemia, wherein the obtained white peony extract has a good therapeutic effect on a hyperuricemia animal model; mainly inhibiting uric acid production by inhibiting the activity of xanthine oxidase in serum and liver, while downregulating the levels of renal tissue proteins URAT1 and GLUT9, and upregulating the levels of renal tissue proteins OAT1 and OAT3 to reduce uric acid reabsorption and promote uric acid excretion, thereby achieving the purpose of reducing uric acid levels. Furthermore, the white peony extract is synergistically used with the currently commonly used uric acid-lowering drug allopurinol to develop a more effective and safe uric acid-lowering treatment plan.
Owner:ANHUI XIEHECHENG PHARM TABLET CO LTD

Application of tsRNA-3025a as acute myocardial infarction prognostic marker and myocardial ischemia-reperfusion injury treatment target

PendingCN121975930AEffectively assess heart failureEffectively assess riskOrganic active ingredientsMicrobiological testing/measurementPharmaceutical drugAntagomir
The invention relates to application of tsRNA-3025a as a prognostic marker of acute myocardial infarction and a treatment target spot of myocardial ischemia reperfusion injury. A DNA (Deoxyribonucleic Acid) sequence corresponding to the tsRNA-3025a is shown as SEQ ID NO: 1: 5 '-ATCCTGCCGACTACGCCA-3'. The tsRNA-3025a can be used for treating acute myocardial infarction and myocardial ischemia reperfusion injury. In the aspect of prognosis, a detection kit is provided, and the risk of heart failure and short-term adverse events of a patient is evaluated by quantitatively detecting the expression level of the tsRNA. In the aspect of treatment, the invention provides the application of the anti-tagomir for inhibiting the function or expression of tsRNA-3025a in the preparation of the medicine for treating the myocardial ischemia reperfusion injury, and the anti-tagomir is subjected to specific chemical modification. A novel biomarker is provided for prognosis risk stratification of acute myocardial infarction, and an effective treatment strategy is provided for prevention and treatment of myocardial ischemia-reperfusion injury.
Owner:SHANGHAI TONGREN HOSPITAL

Application of potential active ingredient 4-methylesculetin of Xiasangju in preparation of medicine for preventing and treating diabetes mellitus

The invention discloses application of a potential active component 4-methylesculetin of Xiasangju in preparation of a medicine for preventing and treating diabetes, and belongs to the field of medicine. The invention provides an application of 4-methylesculetin in preparation of a medicine for preventing and treating diabetes, which can promote the consumption of glucose by cells, reduce the level of ROS and MDA in liver tissues and increase the level of SOD and GSH-PX in the liver tissues. According to the invention, on the basis of the Xiasangju, the medicinal components of the Xiasangju are researched, the medicinal active components and the administration dosage are defined, the administration safety is improved, and the Xiasangju also plays an important role in preventing and treating diabetic complications.
Owner:GUANGZHOU XINGQUN PHARMA

Pharmaceutical composition for treating hashimoto thyroiditis

The invention discloses a pharmaceutical composition for treating hashimoto thyroiditis, and belongs to the technical field of traditional Chinese medicines. According to the pharmaceutical composition, astragalus membranaceus and codonopsis pilosula are used as monarch drugs to tonify qi, raise yang, tonify qi and strengthen body resistance; radix bupleuri, rhizoma cyperi and radix curcumae are used as ministerial drugs for soothing liver-qi stagnation, expelling evil, soothing liver-qi, regulating qi and harmonizing blood; humifuse euphorbia herb, lucid ganoderma and oldenlandia diffusa are used as adjuvant drugs for clearing away heat and toxic materials, reinforcing qi, nourishing blood and tranquilizing; the whole formula has the effects of tonifying qi, soothing the liver and clearing heat together. All the medicines are combined to effectively improve the symptoms of patients with hashimoto thyroiditis and reduce the thyroid autoantibody level. In addition, the pharmaceutical composition is good in safety, and a traditional Chinese and western medicine combined treatment strategy for hashimoto thyroiditis can be further popularized in the future.
Owner:LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE

Acid-resistant cholate-resistant lactobacillus plantarum and application thereof

The invention provides acid-resistant and cholate-resistant lactobacillus plantarum and application thereof, and relates to the technical field of microorganisms. The invention provides a strain with the capacity of degrading nucleic acid and inhibiting xanthine oxidase, namely lactobacillus plantarum HXJS3-1, and the lactobacillus plantarum HXJS3-1 has the effects of reducing the uric acid level and preventing and treating hyperuricemia and gout. In addition, the lactobacillus plantarum HXJS3-1 also has a certain anti-inflammatory effect and an effect of enhancing immunity. And a novel probiotic or medicine material is provided for treatment of hyperuricemia and related diseases thereof. The lactobacillus plantarum HXJS3-1 also has the characteristics of acid resistance, cholate resistance and no influence of existence of a carbon source and a nitrogen source, so that the lactobacillus plantarum HXJS3-1 can be widely applied to various scenes.
Owner:BLOOMATURE BIOTECHNOLOGY CO LTD

Synthesis method of novel inhalable lipidosome and application of novel inhalable lipidosome in ARDS treatment

The invention provides a synthesis method of a novel inhalable liposome and an application of the novel inhalable liposome in ARDS (arterial thrombosis syndrome) treatment, and the synthesis method comprises the following steps: firstly, mixing DSPE-PEG2K-TK-NHS and tocilizumab (TCZ: Tocilizumab) to form a lead compound DSPE-PEG2K-TK-TCZ; the preparation method comprises the following steps: dissolving DPPC, cholesterol, DSPE-TK-PEG2k and FG4592 in 5mL of chloroform, carrying out reduced pressure evaporation in a sample bottle to form a film, and adding 3mL of deionized water to prepare Lip-coated RF; and then stirring and incubating the DSPE-PEG2K-TK-TCZ and the Lip (at) RF, so as to form the Lip (at) RFT. As a functional nano-material with ultra-small size, good biocompatibility, excellent ROS removal capability and ROS responsive drug release, the nano-material is used for treating ARDS. The invention has the advantages that: the Lip-coated RFT relieves lung oxidative stress, inflammatory response, protein permeability and histological severity in the LPS-induced mouse ALI model. Therefore, Lip at RFT can be used as a new way for treating ARDS. Aerosol inhalation of Lip-coated RFT can effectively improve the severity of ARDS.
Owner:THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV

High heat dissipation type direct current permanent magnet synchronous servo motor and use method

The invention discloses a high heat dissipation type direct current permanent magnet synchronous servo motor and a using method, and relates to the technical field of motors, the high heat dissipation type direct current permanent magnet synchronous servo motor comprises a center shaft and a stator, a rotor is arranged in the middle of the outer surface of the center shaft, the stator sleeves the rotor, and a sealing cover is arranged on one side of the outer surface of the center shaft. As the temperature of the electric brush assembly rises, the thermal expansion coefficient of the material can cause slight deformation or position adjustment of the electric brush, and the change can help maintain good contact pressure between the electric brush and the commutation copper sheet, so that contact resistance increase caused by temperature rise is reduced; graphite powder generated by abrasion of an electric brush can form a layer of conductive film on the surface of the commutation copper sheet, although the graphite is a conductor, if the graphite is not uniformly distributed, poor local contact is caused, and proper temperature control and design can ensure that the graphite layer is more uniformly distributed on the commutation copper sheet, and on the contrary, the electric contact quality can be improved.
Owner:HANGZHOU NAZHI MOTOR CO LTD

Uric acid reducing composition containing fructus gardeniae and preparation method of uric acid reducing composition

The invention provides a uric acid reducing composition containing fructus gardeniae and a preparation method of the uric acid reducing composition, and belongs to the technical field of medicines. The preparation method comprises the following steps: fermenting mulberry leaves, chicory, cape jasmine and kudzu vine roots through lactobacillus rhamnosus and bifidobacterium longum, separating probiotics from fermentation liquor, adding immobilized ionic liquid into the fermentation liquor, introducing carbon dioxide for adsorption, filtering, adding solids into ethanol, heating for desorption, concentrating to obtain an extract 1, precipitating filtrate with ethanol to obtain an extract 2, and carrying out freeze-drying to obtain the folium mori-chicory-cape jasmine extract. The preparation method comprises the following steps: embedding probiotics together with sodium alginate to prepare a uric acid-reducing embedding material, and uniformly mixing the uric acid-reducing embedding material with the extract 1, vitamin C and tea polyphenol to prepare the uric acid-reducing composition containing fructus gardeniae. The prepared uric acid reducing composition containing fructus gardeniae can promote uric acid excretion, inhibit sodium urate crystallization, improve the antioxidant effect, repair intestinal barriers, relieve inflammation, inhibit xanthine oxidase (XOD) activity and expression and reduce the blood uric acid level, has a good uric acid reducing effect and has a wide application prospect.
Owner:FOSHAN GOLDEN HEALTH TECH CO LTD +1

Application of plasmalogen in preparation of medicine for promoting spinal cord injury repair

The invention discloses application of plasmalogen in preparation of a medicine for promoting spinal cord injury repair. The invention further discloses application of the plasmalogen in preparation of drugs for regulating neuroinflammation or oxidative stress in spinal cord injury. The invention also discloses application of the plasmalogen in preparation of a medicine for promoting motor function recovery after spinal cord injury. The invention further discloses application of the plasmalogen in preparation of a medicine for neuroprotection in spinal cord injury. The invention further discloses application of the plasmalogen to preparation of a medicine for nerve cell myelin sheath regeneration after spinal cord injury. The invention also discloses application of the plasmalogen in preparation of a medicine for promoting nerve fiber regeneration after spinal cord injury. It is found that plasmalogen can effectively reduce the ROS level and regulate and control neuroinflammation and oxidative stress levels, so that neuronal axis mutability and apoptosis are reduced, and neuronal myelin regeneration is promoted.
Owner:WUXI NO 2 PEOPLES HOSPITAL

External traditional Chinese medicine preparation for lymphedema

The invention provides an external traditional Chinese medicine preparation for lymphedema, and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from astragalus membranaceus, cassia twig, poria cocos, akebiaquinata, ligusticum wallichii, salvia miltiorrhiza, radix bupleuri, scutellaria baicalensis, lalang grass rhizome and herba lycopi, and all the medicines are combined to jointly achieve the effects of tonifying qi, activating blood, inducing diuresis, soothing liver-qi stagnation and clearing away heat and toxic materials. The traditional Chinese medicine preparation has obvious edema eliminating and anti-inflammatory effects on lymphedema model mice, and the treatment effect is remarkable. Meanwhile, the traditional Chinese medicine preparation for external treatment of lymphedema in traditional Chinese medicine provided by the invention can remarkably improve clinical symptoms of a patient, relieve pain of the patient, help the patient recover a functional state, reduce the level of inflammatory factors, promote edema absorption of the patient and remarkably relieve the lymphedema condition of an affected limb, and the curative effect is remarkable.
Owner:ZHENGZHOU CENT HOSPITAL