622results about How to "Lower level" patented technology

A right-hand circularly-polarized patch antenna comprising a ground plane and a patch connected to each other with one or more wires for which the wire shape and location of the end points are selected such that they do not cause an antenna mismatch, and the electrical current carried in the wires produces an extra electromagnetic field subtracted from the patch field in the nadir direction.

The invention relates to the technical field of agricultural micro-ecological application, and discloses a method for improving the growth and drought resistance of oats by using arbuscular mycorrhizal fungi, the arbuscular mycorrhizal fungi having a close symbiotic relationship with the oats are selectively utilized, and the symbiotic relationship between the arbuscular mycorrhizal fungi and the oats is established in a condition control mode. Oat growth is promoted, and drought adaptability is improved. The AM fungi used in the method are selected from rhizosporidium intraradices or glomus mosseae, corn or trifolium repens is taken as a host, the two AM fungi are propagated in a propagation medium respectively, then two arbuscular mycorrhizal fungi inoculants and oat are co-cultured in a symbiotic culture medium respectively, and the two arbuscular mycorrhizal fungi inoculants and oat are co-cultured in a symbiotic culture medium respectively. An effective way for improving beneficial symbiosis of AM fungi and hosts under adverse conditions is provided, the infection symbiosis relation of the AM fungi to host plants is improved manually, and the yield of dry land oats is increased.

The invention provides a preparation method and application of casei paracasei IOB413 after-generation powder, and relates to the field of microorganisms. Tartary buckwheat is used as a solid-state fermentation culture medium, and the lactobacillus paracasei IOB413 is fermented and then crushed to prepare the lactobacillus paracasei IOB413 after-generation powder with high flavone content. The flavonoid content of the metagenic powder prepared by the method is far higher than that in tartary buckwheat and casei paracasei IOB413, the levels of tumor necrosis factor alpha (TNF-alpha) and interleukin (IL-6) can be reduced, the level of anti-inflammatory factor interleukin (IL-10) can be increased, the gingival index and the dental plaque index can be reduced, the growth of streptococcus mutans can be inhibited to a certain extent, and the metagenic powder can be used for preventing and treating the dental plaque. The oral micro-ecology is improved.

The invention discloses bifidobacterium animalis subsp. Lactis BLa79 as well as application, a product and a method thereof, and belongs to the technical field of microorganisms. The preservation number of the bifidobacterium animalis subsp. Lactis BLa79 is CGMCC (China General Microbiological Culture Collection Center) NO. 32426, and the preservation number of the bifidobacterium animalis subsp. Lactis BLa79 is CGMCC NO. 32426. Based on the strain, the invention also provides application and related products of the strain. The BLa79 strain has broad-spectrum antibacterial performance, has the function of regulating intestinal flora, can effectively relieve ulcerative colitis, and can relieve colitis by increasing body weight, reducing DAI score, reducing spleen index, inhibiting colonic atrophy, reducing proinflammatory factor level and promoting SIgA secretion.

The invention relates to the technical field of microorganisms, in particular to a viable bacterium preparation of a lactobacillus paracasei strain as well as a preparation method and application of the viable bacterium preparation. The viable bacterium preparation comprises a lactobacillus paracasei strain and auxiliary materials, and the preservation number of the lactobacillus paracasei strain is CGMCC (China General Microbiological Culture Collection Center) No.27974. The viable bacterium preparation can inhibit the growth of streptococcus mutans, reduce the formation of a dental plaque biofilm caused by the streptococcus mutans, reduce the content of a mature dental plaque biofilm, inhibit the level of water-insoluble exopolysaccharides generated by the streptococcus mutans, reduce the expression quantity of cariogenic genes gtfB, gtfC, gtfD, ftf and LuxS of the streptococcus mutans, improve the cariogenic activity of the streptococcus mutans and improve the cariogenic activity of the streptococcus mutans. The adhesion rate of streptococcus mutans on a hydroxyapatite tooth model is reduced, and a beneficial in-vitro probiotic function is achieved.

The invention discloses application of an RNF130 activator in preparation of a medicine for preventing and / or treating ischemic heart disease, and belongs to the technical field of biological medicine. Research results show that when an RNF130 activator is given in a mouse of a myocardial ischemia reperfusion injury model, the left ventricular ejection fraction and the left ventricular short-axis shortening rate of the mouse can be improved, myocardial tissue pathological injury can be relieved, the protein expression levels of NOX-2, BAX and TNF-alpha are reduced, the myocardial infarction area is reduced, and myocardial cell apoptosis is reduced; therefore, the RNF130 activator has prevention and treatment effects on the myocardial ischemia-reperfusion injury, that is, the RNF130 activator can be used as an effective component of the medicine for preventing or treating diabetes complicated by myocardial ischemia-reperfusion injury, and a new strategy is provided for preparation of the medicine for preventing and treating myocardial ischemia-reperfusion injury.

The invention belongs to the field of daily chemicals, and discloses a strain of bifidobacterium adolescentis, the classification name of the bifidobacterium adolescentis BF23BA001 is bifidobacterium adolescentis, the preservation number is CGMCC NO.26999, and the strain of bifidobacterium adolescentis BF23BA001 is named as bifidobacterium adolescentis BF23BA001. The preservation date is March 31, 2023, and the preservation unit is China General Microbiological Culture Collection Center (CGMCC); the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. Compared with other commercially available similar bacteria, the strain has unique advantages in the production of small molecule peptides and gamma-aminobutyric acid, has a remarkable anti-wrinkle advantage according to the functional characteristics of the small molecule peptides and gamma-aminobutyric acid, and has a remarkable anti-wrinkle effect through subsequent functional verification. The method is of great significance to further improvement of whitening, brightening, repairing and anti-aging effects of yeast fermentation products. In addition, the invention further discloses a composition for inhibiting generation and accumulation of lipofuscin, application based on the composition and cosmetics.

The invention provides a communication perception integrated beamforming method and system for suppressing distance-angle side lobes, and the method comprises the steps: enabling a base station to communicate with a plurality of users under a digital beamforming ISAC architecture, and carrying out the detection of an air target in a self-transmitting and self-receiving mode at the same time; determining a sensing channel model and a communication channel model to obtain a communication receiving signal at each user position and a sensing receiving signal scattered back to the base station from the target; calculating to obtain the SINR of each user; a distance-angle-Doppler three-dimensional perception fuzzy function based on a digital beam forming ISAC architecture is obtained; extracting an expression of an integral sidelobe of a distance-angle dimension; according to the communication index, the sensing index and the integral sidelobe value in the preset distance-angle sidelobe area, a beam forming matrix of the ISAC system is designed in a joint optimization mode; auxiliary variables are introduced to convert the problem of optimizing the beam forming matrix into the problem of optimizing a covariance matrix of the beam forming matrix, and a feasible solution of the joint design problem is obtained.

The invention discloses plant lactobacillus WH021 and application thereof in preventing and / or relieving neuroinflammation, and belongs to the technical field of microorganisms. The plant lactobacillus WH021 is separated and purified from excrement of healthy babies, is a probiotic with the function of relieving neuroinflammation, and has good application potential in development of food, health care products and drugs for preventing brain inflammation related diseases caused by chronic inflammation of bodies of middle-aged and elderly people.

The invention discloses lactococcus lactis subsp. Lactis and application thereof in fermentation of American cockroach powder. The strain is separated and screened from the intestinal contents of the Amolops nobilis, grows well on an MRS agar culture medium, is not hemolyzed, is sensitive to various common antibiotics, has relatively strong adaptive capacity to the intestinal environment of human and animals, has relatively strong lactic acid production capacity, and has strong inhibition capacity to common intestinal pathogens of human and animals. When the strain is used for fermenting American cockroach powder, the content of bioactive substances such as amino acids, peptides, indoles, pyrimidine and purines can be greatly increased, fermented sterile supernate has an obvious effect on mouse colitis induced by DSS, and the inflammatory factor level is remarkably reduced; the strain opens up a new way for further development and utilization of the traditional Chinese medicinal material periplaneta americana.

The invention discloses lactobacillus mucilaginosus and application thereof in fermentation of sporoderm-broken ganoderma lucidum spore powder. The preservation number of the lactobacillus mucilaginosus is CGMCC (China General Microbiological Culture Collection Center) No.31453. The strain is separated and screened from vaginal secretions of healthy women at the childbearing age, is not hemolyzed, is sensitive to various common antibiotics and has strong lactic acid production capacity, and fermented supernate of the strain has strong growth inhibition capacity on escherichia coli, pseudomonas aeruginosa, staphylococcus aureus, salmonella typhimurium, shigella dysenteriae and gardnerella vaginalis and can be used for producing lactic acid. The compound has strong adhesion ability, growth inhibition ability and apoptosis promoting effect on human cervical cancer cells. When the strain is used for fermenting wall-broken ganoderma lucidum spore powder, the content of bioactive substances such as amino acids and derivatives thereof, fatty acids and steroids in fermentation liquor can be greatly increased, the strain has an obvious anti-inflammatory effect on DSS-induced mouse colitis, and the inflammatory factor level is remarkably reduced. The strain not only has significant application value in functional food and biological agents, but also opens up a new way for further development of ganoderma spores.

The invention discloses an application of a POK erythroid myelogenic factor ZBTB7A in resisting hepatitis B virus. Experiments prove that the overexpression of the ZBTB7A can significantly reduce the level of secreted HBV-related virus protein and significantly inhibit HBV transcription and replication, and a new potential target is provided for treatment of hepatitis B. The research prompts that the ZBTB7A can be used as a novel HBV host limiting factor, lays a foundation for developing novel antiviral drugs, provides more effective treatment schemes for clinical treatment, and has wide application prospects and market potential.

The utility model discloses a PCB structure for improving a clock signal backflow path, which comprises a PCB body, the PCB body comprises a surface wiring layer and a plurality of internal wiring layers which are arranged from top to bottom, the surface wiring layer is provided with a clock signal layer changing hole and GND backflow holes distributed at two sides of the clock signal layer changing hole, and the GND backflow holes are communicated with the internal wiring layers. The center distance between the GND backflow hole and the clock signal layer change hole is smaller than or equal to 3 mm. According to the design, the backflow path of the clock signal is obviously optimized, so that the stable backflow path of the clock signal in the transmission process can be ensured, attenuation and distortion of the clock signal can be reduced, the stability and accuracy of the clock signal can be improved, and the GND backflow hole not only provides the stable backflow path, but also improves the reliability of the clock signal. And electromagnetic radiation generated in the clock signal transmission process is effectively absorbed through the metal grounding property, so that interference to other circuits and systems is reduced.

The invention discloses a whitening nano-emulsion and a preparation method thereof, and relates to the technical field of cosmetics and skin care products. The whitening nano-emulsion is prepared from the following components in percentage by weight: 2.0 to 10.0 percent of an emulsifying agent, 4.0 to 10.0 percent of an emollient, 3.0 to 8.0 percent of glycerol, 3.0 to 8.0 percent of butanediol, 0.5 to 3.0 percent of nicotinamide, 1.0 to 3.0 percent of a Soulixian extract, 0.5 to 3.0 percent of ascorbyl tetraisopalmitate, 0.3 to 3.0 percent of hydrogenated lecithin, 0.1 to 2.0 percent of hydroxyethyl piperazine ethanesulfonic acid, 0.1 to 1.0 percent of SymSitive1609, 0.03 to 0.5 percent of a mulberry root extract, 0.03 to 1.0 percent of cerium oxide and the balance of water. The toothpaste is prepared from the following components in percentage by weight: 0.05 to 0.5 percent of tocopheryl acetate, 0.03 to 0.3 percent of stearyl glycyrrhetinic acid ester, 0.01 to 0.1 percent of poly gamma-sodium glutamate, 0.03 to 0.2 percent of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.2 to 1.0 percent of preservative, 0.01 to 0.1 percent of aromatic and the balance of water, wherein the total The prepared whitening nano-emulsion can solve the problems of excessive addition, difficult absorption and instability of active ingredients of cosmetics, can inhibit DPPH free radical activity, hydroxyl free radical activity and tyrosinase activity through the synergistic effect of all the components, achieves the effects of resisting oxidation, whitening, removing freckles, brightening skin and the like, and does not cause damage to the skin.

The invention discloses a biomarker for early diagnosis of femoral head necrosis and application thereof, and relates to the technical field of biology. The biological marker is a serum mechanical gating cation channel Piezo1. The research finds that after early vascular endothelial cells of femoral head necrosis are damaged, the Piezo1 expression is reduced, so that the Piezo1 in blood is obviously reduced, that is, the serum mechanical gating cation channel Piezo1 can assist MRI to serve as a new index of femoral head necrosis; the monitoring of the level of the serum mechanical gating cation channel Piezo1 provides a new marker for the screening of early femoral head necrosis.

The invention relates to the field of food and health care products, and discloses a composition for dispelling effects of alcohol and protecting liver, which comprises 20-100 parts of ampelopsis grossedentata leaf extract; 50 to 200 parts of a radix puerariae extract; 10-50 parts of a semen hoveniae extract; 10-50 parts of a turmeric extract; 10 to 100 parts of a yeast extract; 5-50 parts of a licorice extract; and 5 to 20 parts of pyrroloquinoline quinone disodium salt. The ampelopsis grossedentata leaf extract, the kudzuvine root extract and the hovenia dulcis thunb extract are utilized, alcohol decomposition is promoted, the blood ethanol concentration is reduced, and drunkenness symptoms are relieved. Puerarin improves activity of liver metabolic enzymes, accelerates discharge of ethanol and acetaldehyde, and reduces liver damage. The anti-oxidation effects of dihydromyricetin and PQQ can eliminate alcohol metabolism free radicals and protect liver cells. The components such as puerarin, hovenia dulcis thunb, curcumin and glycyrrhizic acid jointly promote liver cell regeneration, inflammation and oxidative damage are reduced, the levels of ALT and AST in serum are reduced, and liver health is maintained.

The invention discloses a Weissella cibaria X1 strain with functions of regulating metabolism and reducing uric acid and an application of the Weissella cibaria X1 strain. 49 lactic acid bacteria are screened from samples of fermented vegetables, healthy human body oral cavities and piglet feces, and 10 lactic acid bacteria are screened through PCA analysis on the basis of metabolism regulation and obesity inhibition ability; the method comprises the following steps: carrying out safety evaluation and uric acid reduction capability evaluation on 10 strains, finally screening out a strain X1, and identifying that the strain X1 is Weissella cibaria; the X1 strain and metabolites thereof have the function of reducing uric acid, excretion of uric acid can be promoted by adjusting expression levels of OAT1, UOX and HNF4A in vivo, expression of HPRT is adjusted to prevent excessive generation of uric acid and further reduce the level of uric acid, and a new way is provided for developing a uric acid reducing method without side effects.

The invention relates to a probiotic agent capable of resisting helicobacter pylori infection and application of the probiotic agent. The bacterial strains in the probiotic agent capable of resisting helicobacter pylori infection are composed of a Bifidobacterium animalis subsp. Lactis (Bifidobacterium animalis subsp. Lactis). Lactis BLa80 bacterial strain and a Lactobacillus acidophilus LA18 bacterial strain. The invention further relates to a preparation method of the probiotic agent capable of resisting helicobacter pylori infection and application of the probiotic agent capable of resisting helicobacter pylori infection. The two strains can cooperate with each other and promote each other, and have a synergistic effect in the aspect of resisting helicobacter pylori infection, specifically, the level of an Hp-IgG antibody and the level of endotoxin of a mouse infected with helicobacter pylori are remarkably reduced; the levels of serum inflammatory factors such as IL-17A, IL-10, IL-23, IFN-beta and IFN-gamma of mice infected with helicobacter pylori are regulated, and inflammatory response caused by helicobacter pylori infection is inhibited; the activity of pepsin, the activity of cellulase and the activity of alpha-amylase are obviously improved, so that the digestive ability of the stomach is enhanced.

The invention relates to the technical field of screening and application of probiotics, and particularly provides a novel bacillus coagulans strain and application of the novel bacillus coagulans strain. The bacillus coagulans is screened from naturally fermented soybean paste, has good biological safety, strong stress resistance to gastrointestinal tract environment, high yield of exopolysaccharide and protease, strong bacteriostasis and oxidation resistance, can efficiently degrade cholesterol, is beneficial to maintaining intestinal health, and can be widely applied to the fields of food, health care products and the like.

The invention discloses a construction method and application of a caenorhabditis elegans inflammation model, belongs to the technical field of model biology, and provides a construction method of a caenorhabditis elegans inflammation model, which comprises the following steps: putting L1-stage caenorhabditis elegans into a lipopolysaccharide solution, and carrying out induced culture to obtain induced cultured caenorhabditis elegans; placing the caenorhabditis elegans in a chromosome system, performing staining culture and centrifugation to obtain dyed caenorhabditis elegans, and placing the dyed caenorhabditis elegans on a culture medium for recovery to obtain the caenorhabditis The surface of the caenorhabditis elegans is provided with a transparent cuticle anatomical structure, the intestinal barrier damage condition is easy to observe after the intestinal tract is dyed by a dye, and the cell proliferation, tissue development and tissue integrity of the caenorhabditis elegans are easy to carry out fluorescence microscope and morphological analysis. A caenorhabditis elegans inflammation model is constructed through lipopolysaccharide induction, and a new experimental animal model is provided for screening anti-inflammatory drugs.

The invention belongs to the technical field of preparation of postbiotics, and discloses a preparation method and application of lactic acid bacteria fermented Chinese chestnut protein postbiotics for improving systemic chronic inflammations, Chinese chestnuts are subjected to shelling, grinding and degreasing treatment, and degreased Chinese chestnut powder is obtained; resuspending the degreased Chinese chestnut powder in distilled water, adjusting the pH value, and stirring; performing solid-liquid separation and magnetic stirring; carrying out solid-liquid separation, resuspending and adjusting the pH value; dialyzing to obtain Chinese chestnut protein powder; mixing with glucose powder, and redissolving in distilled water; and mixing with lactic acid bacteria and carrying out aerobic fermentation to obtain the Chinese chestnut protein metaplasm product. The bioactive peptides contained in the Chinese chestnut protein metaplasm prepared by the method have potential anti-inflammatory activity, can effectively inhibit proinflammatory medium secretion of macrophages and intestinal epithelial cells, and improve glucose and lipid metabolism disorder and intestinal barrier function damage related to chronic inflammation of a body. The bioactive peptide contained in the postbiotic product disclosed by the invention has an anti-inflammatory effect.

The invention discloses an application of probiotics Blauria winteriae in the preparation of a medicine or food for improving or treating the inflammatory bowel disease of children, and relates to the field of medicines or foods for improving or treating the inflammatory bowel disease of children. According to the invention, the probiotic Blauria wexlerae is used as an effective component to be prepared into medically and food acceptable dosage forms, so that the children inflammatory bowel disease can be obviously improved or treated, and the application value of the probiotic is improved.

The invention provides a Lactobacillus casei GG002, a bacteriocin solution of the Lactobacillus casei GG002, freeze-dried powder of the Lactobacillus casei GG002 and application of the bacteriocin solution and the freeze-dried powder of the Lactobacillus casei GG002 to treatment of oral ulcer, and belongs to the technical field of microorganisms. The invention finds that the lactobacillus casei GG002 can inhibit streptococcus mutans, fusobacterium nucleatum and porphyromonas gingivalis, and has the effect of treating oral ulcer. The invention further provides a bacteriocin solution, freeze-dried powder and metagen of the casei casei GG002, and the bacteriocin solution, the freeze-dried powder and the metagen can be used for effectively treating the oral ulcer.

The invention discloses a preparation method and application of a response type NO release anticoagulant hydrogel material. The preparation method comprises the following steps: providing methylacryloylated recombinant collagen; providing methacrylated hyaluronic acid; providing caffeic acid arginine amide modified hyaluronic acid; the response type NO release anticoagulant hydrogel material is obtained by taking methylacryloylated recombinant collagen, methylacryloylated hyaluronic acid and caffeic acid arginine amide modified hyaluronic acid as raw materials. The prepared hydrogel material has the advantages of resisting bacteria, promoting proliferation of endothelial cells, inhibiting proliferation of smooth muscle cells, resisting inflammation, promoting angiogenesis, inhibiting thrombosis and the like, arginine can serve as an endogenous NO donor in blood to release NO molecules, and therefore the effect of promoting vascular endothelial repair is achieved, and the hydrogel material has the advantages of being capable of resisting bacteria, promoting proliferation of endothelial cells, inhibiting proliferation of smooth muscle cells, resisting inflammation, promoting angiogenesis, inhibiting thrombosis and the like. The introduced NO molecules enable the hydrogel material to have good anticoagulant performance, and the hydrogel material is expected to be used for preparing an artificial blood vessel anticoagulant coating.

The invention discloses application of atypical retinoid A-7 in preparation of androgen receptor inhibitors and antitumor drugs, and belongs to the technical field of medicines. It is proved for the first time that AR can be degraded through a CMA pathway, and the atypical retinoid A-7 serving as an AR inhibitor can obviously reduce the AR protein level in prostate cancer cells; in addition, the Atypic retinoids 7 can be used for inhibiting the growth and proliferation capacity of the prostate cancer cells LNCaP; in addition, the invention further provides an anti-tumor medicine composition, the anti-tumor medicine composition comprises the Atypic retinoid-7 and Enzalutamide, and the anti-tumor medicine composition can be used for treating the prostatic cancer and has important clinical significance.

The invention relates to the technical field of microorganisms, in particular to a lactobacillus paracasei strain as well as a fermentation product and application thereof. The preservation number of the lactobacillus paracasei strain is CGMCC (China General Microbiological Culture Collection Center) No.27974. The Lactobacillus paracasei can inhibit the growth of Streptococcus mutans, reduce the formation of a dental plaque biofilm caused by Streptococcus mutans, reduce the content of a mature dental plaque biofilm, inhibit the level of water-insoluble exopolysaccharides generated by Streptococcus mutans, and reduce the expression quantity of cariogenic genes gtfB, gtfC, gtfD, ftf and LuxS of Streptococcus mutans, and can be used for fermentation production of fermented milk. And oat milk and other fermentation products.

The invention relates to a fruit and vegetable juice beverage, and belongs to the technical field of beverages, the fruit and vegetable juice beverage comprises the following raw materials: fruit and vegetable juice enzymolysis fermentation broth, camellia oil, tartary buckwheat polypeptide, a sweetening agent, a stabilizer and distilled water; raw materials of the fruit and vegetable juice enzymolysis fermentation liquor comprise vegetable raw materials, fruit raw materials, enzyme bacteria raw materials and deionized water. The enzyme and bacterium raw materials comprise cellulase, lactobacillus plantarum liquid, helicase, basidiomycetes liquid and neurospora crassa liquid. The raw materials of the fruit and vegetable juice enzymolysis fermentation liquor are subjected to bacterium-enzyme synergistic modification treatment, so that the content of soluble dietary fibers in the fruit and vegetable juice enzymolysis fermentation liquor is remarkably increased, and the fruit and vegetable juice beverage can effectively have the effects of promoting gastrointestinal motility and reducing cholesterol by taking the fruit and vegetable juice enzymolysis fermentation liquor as the raw materials to participate in preparation of the fruit and vegetable juice beverage; in addition, the fruit and vegetable juice enzymolysis fermentation liquor, the camellia oil and the tartary buckwheat polypeptide are combined to achieve a synergistic effect, so that the prepared fruit and vegetable juice beverage has an extremely good cholesterol lowering effect.

The invention relates to the technical field of microorganisms, in particular to lactobacillus rhamnosus capable of preventing or treating inflammatory bowel diseases and promoting digestion and application of the lactobacillus rhamnosus, and belongs to the technical field of biological medicine. The invention provides a strain of lactobacillus rhamnosus R7970, wherein the preservation number of the lactobacillus rhamnosus R7970 is CGMCC (China General Microbiological Culture Collection Center) 22244, and the preservation number of the lactobacillus rhamnosus R7970 is CGMCC 22244. The lactobacillus rhamnosus R7970 can be used for effectively preventing inflammatory enteritis (IBD) and has a prevention effect on intestinal inflammation, and meanwhile, the lactobacillus rhamnosus R7970 can be used for improving the nutrition digestion and absorption functions of intestinal tracts. Therefore, the lactobacillus rhamnosus R7970 can be applied to prevention of IBD, can be used for preparing probiotic preparations, common foods, health foods and biological pharmacy for improving intestinal health, is convenient for industrial production, and has great popularization value.

The invention provides a compound probiotic composition for improving allergic rhinitis as well as a preparation method and application thereof, and belongs to the technical field of biological preparations. Comprising a composite probiotic liquid, an auxiliary agent, a humectant and a thickening agent, wherein the composite probiotic liquid is composed of a composite bacterium fermentation liquid and probiotic substances, and the composite fermentation liquid is prepared by respectively fermenting saccharomyces boulardii, two bifidobacteria, lactobacillus reuteri, lactobacillus rhamnosus and streptococcus thermophilus. According to the compound probiotic composition, growth of probiotics is promoted through different probiotics, flora balance is adjusted and immunity is improved through mutual cooperation of the different probiotics, rhinitis symptoms are improved, meanwhile, components such as centipeda minima are added to serve as auxiliaries, and the effect of improving rhinitis symptoms is achieved. And the probiotics and the compound probiotics can achieve a synergistic effect to jointly improve the symptoms of the allergic rhinitis.

The invention discloses lactobacillus crispatus for improving female genital tract microenvironment and immune aging and application of the lactobacillus crispatus, and belongs to the field of probiotics. The probiotic lactobacillus crispatus ProSci-38 disclosed by the invention can be used for effectively improving the symptoms such as pruritus vulvae, causalgia of vagina, abnormal vaginal secretion and the like of patients with vaginitis; mainly through the effect of intestinal tract-vaginal axis, the proportion of lactobacillus is increased, the proportion of harmful bacteria is reduced, the balance of vaginal flora is recovered, and the acidic environment of vagina is maintained; meanwhile, the inflammatory factor level can be reduced, the immune function of the vagina of a patient can be improved, so that the vagina environment is improved, the infection risk is reduced, and the preparation method has a great prospect in preparation of products for relieving and / or treating vaginitis.