The invention discloses a preparation method of pyracantha fortuneana fruit sauce. The preparation method comprises the following steps: selecting pyracantha fortuneana as a main raw material, cleaning, pulping, performing enzyme treatment, dosing, homogenizing, concentrating, canning, sterilizing, storing and the like. According to the pyracantha fortuneana fruit sauce prepared by adopting the method, peculiar flavor substances of the pyracantha fortuneana are reserved as far as possible through pectase treatment, the utilization rate and nutritional value of the pyracantha fortuneana are increased, and the coarse mouth feel of the fruit sauce is removed through homogenizing treatment; the fruit sauce is moderate in sourness and sweetness, fine in sauce body, proper in viscosity and coordinative in flavor, has pure, rich, elegant and harmonious peculiar flavor of the pyracantha fortuneana, and has the effects of removing qi stagnation, relieving dysentery, activating blood, stopping bleeding, promoting digestion, improving the immunity of a human body and the like after being often eaten.