2377results about How to "Good biocompatibility" patented technology

The invention belongs to the technical field of biodegradable materials, and particularly relates to an environment-friendly degradable modified composite material, a preparation method and application. The material comprises PBAT, PBS, PLA, an inorganic mineral filler, natural plant fibers, PBAT-PTMO, nano-silica, an auxiliary agent and a plasticizer. In the preparation process, PLA is prevented from being hydrolyzed in vacuum drying, calcium carbonate and nano silicon dioxide are preheated and activated, natural plant fibers are dispersed through steam explosion and ethanol treatment, and raw material pretreatment comprises high-speed mixing and agglomeration breaking and medium-speed secondary premixing so as to realize uniform distribution. The co-rotating twin-screw extruder accurately controls the temperature, the speed, the rotating speed and the length-diameter ratio, and ensures melting plasticizing, uniform mixing and stable extrusion molding. According to the invention, by adopting accurate proportioning of multiple raw materials and a modification treatment process, the properties of mechanics, degradation, processing and the like of the material are synergistically improved, and the material is widely applied to multiple fields such as packaging bags, disposable tableware and agricultural plastic mulching films.

The invention relates to a zirconia-based all-ceramic false tooth and a preparation method thereof. A core layer of the zirconia-based all-ceramic false tooth is prepared from the following components in parts by mass: 90 to 94 parts of ZrO2, 5 to 9 parts of Y2O3, 0.1 to 0.5 part of Al2O3, 0.01 to 0.5 part of Fe2O3, 0.01 to 0.5 part of Er2O3 and 0 to 0.2 part of MnO2, and a shell layer of the zirconia-based all-ceramic false tooth is prepared from the following components in parts by mass: 24.5 to 49.5 parts of CaCO3, 45 to 50 parts of SiO2, 0 to 25 parts of MgO, 0.01 to 0.5 part of Fe2O3, 0.01 to 0.5 part of Er2O3 and 0 to 0.2 part of MnO2. The preparation process comprises the following steps: performing dry pressing and isostatic pressing on raw materials of the core layer, presintering, and carving to obtain a zirconia-based false tooth biscuit; meanwhile, calcining raw materials of a shell layer, then adding deionized water, a dispersing agent and an adhesive, and carrying out ball milling and mixing to obtain calcium-magnesium-silicon-based ceramic slurry; and coating the calcium-magnesium-silicon-based ceramic slurry on the surface of the zirconium oxide-based false tooth biscuit, and sintering to obtain the zirconium oxide-based all-ceramic false tooth provided by the invention. The zirconia-based all-ceramic false tooth has good jade texture and is closer to the natural color of natural teeth.

The preparation method comprises the following steps: mixing a tannic acid solution and a tetravalent cerium salt solution, adjusting the pH value to 9-11, and reacting to obtain the cerium tannate nano-enzyme, the molar ratio of the tannic acid to the tetravalent cerium salt is (1-4): 1; the hydration dynamic diameter of the cerium tannate nano-enzyme is 20 to 80 nm. The TA-Ce nano-enzyme prepared by the preparation method disclosed by the invention is smaller in particle size, can keep stable and good dispersibility in a physiological environment, and has good biocompatibility, low hemolysis rate and small systemic toxicity; meanwhile, the compound has good kidney targeting property, can be effectively enriched into the injured kidney, eliminates various ROS (reactive oxygen species) and relieves oxidative stress by utilizing unique redox cycle between Ce < 3 + > and Ce < 4 + > states, and has a good effect in treating acute kidney injury induced by rhabdomyolysis and / or cis-platinum. The research lays a foundation for the metal polyphenol nano material in the treatment of acute kidney injury.

The invention relates to the field of biomedical materials, in particular to a novel composite collagen material for wound repair, and particularly relates to a preparation method of the novel composite collagen material containing 21-type recombinant humanized collagen (ColpepA1 21) and application of the novel composite collagen material in wound repair. The ColpepA1 21 is used for remarkably promoting key biological reactions in the wound healing process, including accelerating cell migration, enhancing the skin hydration state and barrier function and improving the stability and elasticity of the skin structure, a novel composite collagen material is developed, wound healing and cell regeneration can be effectively promoted, and oxidative damage can be relieved.

The invention belongs to the technical field of metal organic frameworks, and particularly relates to a high-performance photocatalytic metal organic framework antibacterial material as well as a preparation method and application thereof. The preparation method comprises the following steps of: growing a metal organic framework UiO 66 which takes a cerium element as a metal node on a single-layer graphene oxide UiO66 (at) GO in situ, loading arginine small molecules in the MOF framework to obtain a high-performance photocatalytic MOF antibacterial material UiO66 (at) GO (at) arg, forming a nano hydrogel with a stable three-dimensional structure with chitosan, and performing antibacterial treatment by using the nano hydrogel as a wound dressing. The Ce-based MOF composite QCS / GO-UiO 66-coated arg / PNIPAm hydrogel prepared by the preparation method disclosed by the invention has excellent properties such as elasticity, adhesive power, water absorption and biocompatibility; and under illumination, the photocatalyst has an excellent photocatalytic sterilization effect, and has a good killing effect on escherichia coli and staphylococcus aureus.

The invention discloses multifunctional hydrogel and application thereof, and belongs to the technical field of biological medicine. According to the multifunctional hydrogel, ketal mercaptan with two hydrazide ends and oxidized dextran are cross-linked to form a cross-linked network containing dynamic covalent bonds. The preparation method comprises the following steps: dissolving ketal mercaptan with two hydrazide ends in deionized water to obtain a ketal mercaptan solution, dissolving oxidized dextran in deionized water to obtain an oxidized dextran solution, mixing the ketal mercaptan solution with the oxidized dextran solution, and standing to obtain the multifunctional hydrogel. The multifunctional hydrogel has pH / ROS dual responsiveness, can respond to inflammation microenvironment and low pH of infectious wounds, remove active oxygen, release therapeutic drugs, regulate macrophage polarization and relieve bacterial infection, thereby playing a key role in inflammation, proliferation and remodeling stages of wound healing to accelerate wound healing. The curcumin-encapsulated liposome is added into the multifunctional hydrogel, so that the antibacterial effect can be further improved.

The invention relates to a composite hydrogel dressing for promoting wound healing as well as preparation and application thereof, and belongs to the technical field of biological medicines. The hydrogel disclosed by the invention is prepared by mixing gelatin, oxidized dextran and metal ion modified metal-organic framework compounds (MOF-Ag and MOF-Cu). In the mixed solution, amino groups in the gelatin and aldehyde groups of the oxidized dextran are subjected to a Schiff base cross-linking reaction, and the composite hydrogel is formed after standing. The loaded MOF-Ag has antibacterial and anti-biofilm effects on staphylococcus aureus and escherichia coli, and the loaded MOF-Cu has similar superoxide dismutase activity and similar glutathione peroxidase activity, so that excessive active oxygen can be removed, and inflammatory response can be relieved. The obtained hydrogel has good biocompatibility, proper mechanical properties and biological adhesion, stable rheological properties, excellent antibacterial and anti-inflammatory functions and a certain hemostatic function.

The invention discloses a plant leaf imitating hydrogel composite material and a preparation method thereof, and belongs to the field of bionic composite materials. The preparation method comprises the following steps: firstly, preparing printing paste by compounding a coloring agent, printing a fabric to obtain a green fabric capable of simulating spectral characteristics of green peaks and red edges of plant leaves, and simulating fence tissues and skeletons in a leaf structure by using the green fabric; then taking a biological material polyvinyl alcohol (PVA) as a base material, adding a monomer with strong hygroscopicity, a cross-linking agent and an initiator, and blending to prepare a hydrogel prepolymer solution; and finally, pouring the hydrogel prepolymer solution into a mold containing the green fabric for copolymerizing, so that hydrogel is directly formed on the surface of the fabric and in pores, and the plant leaf imitating hydrogel composite material is obtained. The material gets rid of dependence on moisture absorption salt, and has the advantages of stable water absorption and simulation effects, good durability and the like.

The invention relates to a biodegradable high-strength medical soft tissue adhesive as well as a preparation method and application thereof. The medical soft tissue adhesive comprises a soft segment, a hard segment and a hard segment chain extender, the soft segment is a polyethylene glycol polymer; the hard segment is isocyanate; the hard segment chain extender comprises a hard segment electrically neutral chain extender and a hard segment ionized chain extender; the molar ratio of the polyethylene glycol polymer to the isocyanate to the hard segment electrically neutral chain extender to the hard segment ionized chain extender is (1-7): (50-95): (14-20): (2-6). The preparation method comprises the following steps: mixing the polyethylene glycol polymer, the hard segment chain extender and the isocyanate, heating and reacting to obtain a mixed reaction system; cooling after the reaction is completed, adding a rheology modifier, a foaming catalyst and a stabilizer into the mixed reaction system, and uniformly mixing to obtain the biodegradable high-strength medical soft tissue adhesive which is suitable for functional composite materials.

The invention discloses composite hydrogel as well as a preparation method and application thereof. The curcumin-EGCG composite hydrogel is prepared by forming a complex through hydrogen-bond interaction between gelatin and epigallocatechin gallate and carrying out chemical crosslinking through Schiff base reaction of curcumin and gelatin. The composite hydrogel disclosed by the invention has a self-healing characteristic or viscosity and a shear thinning characteristic, and is beneficial to local application. The composite hydrogel is loose and porous in structure, the drug loading rate can be increased, the drug can be slowly and controllably released, the treatment effect of the composite hydrogel in androgenetic alopecia is promoted, meanwhile, the solubility of a drug monomer can be remarkably improved, and the problem that the drug solubility is low is solved. The composite hydrogel provided by the invention provides an effective transdermal drug delivery preparation for treatment of skin diseases, and has good clinical application prospects and development values.

The invention provides modified aluminum nitride and a preparation method thereof, and the preparation method comprises the following steps: grinding a mixed material comprising aluminum nitride powder, a dispersing agent and an alcohol solvent to obtain nanoscale aluminum nitride powder with the particle size of 50-400 nm; the nanoscale aluminum nitride powder is subjected to first freeze drying treatment, and freeze-dried aluminum nitride powder is obtained; and mixing a solution containing dopamine with the freeze-dried aluminum nitride powder, and then carrying out second freeze-drying treatment to obtain the modified aluminum nitride. The method is helpful for improving the hydrolysis resistance of aluminum nitride.

The invention discloses self-adaptive Janus supramolecular hydrogel, a preparation method and application of the self-adaptive Janus supramolecular hydrogel as a wet tissue surface adhesive. The hydrogel has an integrated structure and two asymmetric surfaces: an adhesion surface and an anti-adhesion surface. The method is suitable for the wet tissue surface bonding field.

The invention belongs to the technical field of medical materials, discloses hyaluronic acid modified phosphorus-doped double-copper monatomic nano-enzyme (Cu2 / PNC at HA) and a preparation method and application thereof, and aims to solve the problems of low catalytic efficiency and poor selectivity of nano-enzyme. The preparation method comprises the following steps: firstly synthesizing a ZIF-8 carrier, then coating double copper ions and poly (cyclotriphosphoryl-4 ', 4'-diaminodiphenyl ether) (PZM) on the surface of the ZIF-8 through polymerization, and further performing pyrolysis to obtain the Cu2 / PNC nano-enzyme. The catalytic efficiency of the Cu2 / PNC nano-enzyme is remarkably improved through the phosphorus doping effect and double copper single atoms. The hyaluronic acid is adopted to coat the Cu2 / PNC nano-enzyme, so that the biocompatibility is improved, the anti-tumor activity is remarkably improved, the application of the Cu2 / PNC nano-enzyme in the field of biomedicine is expanded, and the huge potential in the aspect of tumor catalytic treatment is shown.

The invention provides a compound phospholipid gel sustained release preparation and a preparation method thereof. The preparation mainly comprises a local anesthetic, a non-steroidal anti-inflammatory drug, phospholipid and water for injection. The preparation can be injected around a surgical incision or directly instilled or coated at the surgical incision to achieve the purpose of long-acting analgesia, and is used for postoperative analgesia.

The invention discloses biomass-based water-plastic plastic as well as a water-plastic forming method, preparation and application thereof, the water-plastic plastic is plastic which can be formed and processed only by utilizing water, and the water-plastic forming method mainly comprises the following steps of water treatment, shape editing and shape fixing of the biomass-based water-plastic plastic. According to the scheme, the plastic can be repeatedly edited into various one-dimensional, two-dimensional or three-dimensional shapes, expensive and complex instruments and equipment are not needed, the high-energy-consumption process such as high temperature and high pressure is avoided, the application scene of the plastic is expanded, and the service life of the plastic is prolonged; the method is a plastic molding processing method which is simple to operate, low in energy consumption, low in cost, green, environment-friendly and carbon-reducing. The biomass-based water-plastic plastic is prepared from biomass which is rich in reserves, low in cost, sustainable, renewable, biodegradable and good in biocompatibility, generally has good mechanical properties and transparency, and can be widely applied to various fields.

The invention discloses a preparation method of an antibacterial PEEK material for bone implantation. The preparation method comprises the following steps: carrying out sand blasting treatment on the surface of a PEEK sample; immersing the sandblasted PEEK sample into a mixed solution containing concentrated sulfuric acid and hydrogen peroxide, and carrying out chemical sulfonation treatment; immersing the sulfonated PEEK sample into a dopamine solution, so that dopamine is oxidized and self-polymerized on the surface to form a PDA coating; immersing the PEEK sample with the PDA coating into an antibacterial drug solution, so that the antibacterial drug is loaded on the surface; carrying out heat treatment on the PEEK sample loaded with the antibacterial drug; thoroughly cleaning the sample, removing uncombined antibacterial drug molecules, and drying; through sand blasting treatment and sulfonation treatment, the surface roughness and hydrophilicity of the PEEK material are remarkably improved, and favorable conditions are provided for adhesion of a dopamine coating and an antibacterial agent; due to introduction of the dopamine coating, the biocompatibility and the adhesion of the material are enhanced, and the dopamine coating also serves as an effective carrier of antibacterial drugs, so that the antibacterial function is maximized.

The invention belongs to the technical field of veterinary preparations, and particularly relates to a tilmicosin premix and a preparation method thereof. The tilmicosin premix is prepared from the following raw materials: tilmicosin, a polylactic acid-glycolic acid copolymer, lecithin, modified hydroxypropyl methyl cellulose, grafted polyvinylpyrrolidone, polyethylene glycol and an antioxidant, a solid dispersion is formed through lecithin and grafted polyvinylpyrrolidone, the solubility and stability of tilmicosin are enhanced, polylactic acid-glycolic acid copolymer nano-microspheres are prepared through a double-emulsion solvent evaporation method, slow release of drugs is achieved, dodecyl modified hydroxypropyl methyl cellulose and polyethylene glycol are combined, and the sustained release effect is achieved. The solubility and the slow release characteristic are further enhanced. The activity of the granular premix is effectively preserved, and the granular premix is convenient to use and transport.

The invention belongs to the technical field of organic compounds, and particularly relates to a multifunctional organic silicon glycosyl amide cationic surfactant as well as a preparation method and application thereof. The preparation method of the surfactant comprises the following steps: carrying out amine ester reaction on glucolactone and N, N-dimethyl dipropylene triamine to obtain a precursor; carrying out substitution reaction on the precursor and bromododecane to obtain an intermediate; the intermediate and 3-chloropropyl methyl dimethoxy silane or 3-chloropropyl methyl trimethoxy silane are subjected to a quaternization reaction, and the surfactant is obtained. The surfactant has good environmental protection property and biocompatibility, is non-toxic and non-irritant, can sterilize and improve the rewettability of the material surface, and has wide application prospects in the aspects of pesticide, textile, daily chemical industry and material transportation and storage.

The invention discloses a multi-metal borate nano-particle as well as a preparation method and application thereof. The preparation method comprises the following steps: in the presence of small molecules with alkyl chains, performing high-temperature thermal decomposition on an organic metal compound or a metal salt compound precursor and organic borate in a solvent, and then centrifuging, modifying, performing ultrafiltration, dialyzing and purifying to obtain the multi-metal borate nanoparticles. The preparation method disclosed by the invention has the characteristics of mildness, high efficiency and strong controllability. The multi-metal borate nanoparticles prepared by the preparation method disclosed by the invention have the advantages of monodisperse size, relatively high magnetic property and good biocompatibility. Therefore, the prepared multi-metal borate nanoparticles not only have multi-modal imaging functions such as magnetic resonance imaging, near-infrared two-region imaging, nuclear medicine imaging and magnetic particle imaging, but also can be used for various treatment means such as magnetocaloric therapy and boron neutron capture therapy; potential advantages are realized in biomedical applications such as magnetic targeting tumor treatment and imaging contrast agents, and high practical values are realized.

The invention discloses a preparation method and application of a manganese-based amino acid coordination polymer, and belongs to the technical field of nano-enzymes and nano-drugs. Divalent manganese salt, histidine and other amino acids are subjected to a co-precipitation reaction to prepare the manganese-based amino acid coordination polymer, and the polymer is of a nanoparticle structure, small in size and high in stability, has enzyme-like activity, catalyzes hydrogen peroxide to generate high-toxicity hydroxyl free radicals and is used for specifically killing tumor cells. The catalyst has the capability of catalytically generating singlet oxygen in the presence of hydrogen peroxide. Meanwhile, the manganese-based amino acid complex has glutathione oxidase-like activity, consumes glutathione to overcome the resistance of tumors to oxidative stress, improves the chemical kinetic curative effect, and has anti-tumor application potential.

The invention discloses a preparation method of sandwich type immunomagnetic beads with high thermal stability, which comprises the following steps: by taking polystyrene microspheres as a template, introducing oil-phase Fe3O4 nanoparticles into the polystyrene microspheres through a swelling method, and then carrying out hydrolytic condensation reaction on the surface of a microsphere assembly by utilizing n-octyltrimethoxysilane OTMS to obtain the sandwich type immunomagnetic beads with high thermal stability. The preparation method comprises the following steps: carrying out surface amination modification on a silicon dioxide thin layer which is grown by hydrolysis of tetraethoxysilane TEOS to realize coating of an outermost organic shell layer, carrying out surface amination modification, and carrying out cross-linking on 1, 4-butanediol diglycidyl ether and erythritol on the surface to form an epoxy polymer layer so as to obtain the sandwich-type immunomagnetic bead with a cross-linked epoxy polymer layer introduced to the outer layer. According to the epoxy group modification process on the surface of the magnetic bead, a direct cross-linking modification process is adopted, so that the operation steps are simplified, and the obtained epoxy group magnetic bead is ensured to show excellent biocompatibility. In addition, the method omits the tedious process of functional group activation, and allows direct coupling with the antibody, thereby greatly improving the efficiency and convenience of the experiment.

The invention relates to a preparation method of a composite nano sponge for efficiently adsorbing rare earth ions in acidic wastewater, a product and application thereof, and belongs to the technical field of rare earth ion separation and purification. The composite nano sponge is prepared by taking cheap and green beta-cyclodextrin, polyvinyl alcohol, phosphorylated chitosan and citric acid as raw materials, mixing beta-cyclodextrin functionalized polyvinyl alcohol and phosphorylated chitosan and taking citric acid as a cross-linking agent. Experimental results show that the composite nano sponge is good in acid resistance, high in adsorption capacity and good in cyclic regeneration capacity, the removal rate of the composite nano sponge to rare earth ions in simulated acid mine water is higher than 92.9%, and the adsorption rate of the composite nano sponge to competitive ions does not exceed 2.0%. The composite nano sponge shows a potential application prospect in the recovery of rare earth ions in acid wastewater, and is expected to improve the current situation that the acquisition way of rare earth elements is single.

The invention relates to a method for mechanically regulating and controlling a nerve cell calcium ion signal by using an Airy beam to control an optical bullet, which comprises the following steps: firstly preparing the optical bullet and culturing HT-22 cells, then dynamically regulating and controlling the cell calcium ion signal, and finally monitoring and recording an image in the regulation and control process in real time through a CMOS (Complementary Metal Oxide Semiconductor) camera. According to the method, non-contact mechanical stimulation on nerve cells can be realized. The spatial resolution limitation of the traditional nerve regulation and control technology is broken through, and a non-invasive and high-biocompatibility nerve signal regulation and control means is provided. Besides, in combination with a real-time fluorescence monitoring technology, the regulation and control effect can be intuitively evaluated, and a brand new tool is provided for neuroscience research and clinical application.

The present application belongs to the field of medical polymer technology, and in particular, relates to a polyacid polymer hydrogel, and its preparation method and application. The polyacid polymer hydrogel involved in the present application mainly contains a polyacid polymer aqueous phase; the preparation method provided includes first dissolving a polycarboxylic acid polymer in an alkaline solution, then dripping a pH adjuster and stirring, and standing to obtain a polycarboxylic acid polymer hydrogel. Among them, after lowering the pH of the alkaline aqueous solution of the polycarboxylic acid polymer, the polycarboxylic acid chains are entangled during the standing process, and the interaction force between the polymer chains is enhanced to form a polycarboxylic acid polymer hydrogel. This type of hydrogel has a simple source of materials and an easy preparation method, which solves the technical problems that the preparation process of the existing polycarboxylic acid-containing polymer hydrogel is cumbersome, toxic reagents are required, and the product hydrogel lacks adhesion and self-healing.

The invention provides a bionic antibacterial peptide, a pharmaceutical composition, application of the bionic antibacterial peptide in preparation of antibacterial drugs and a design method of the bionic antibacterial peptide. A plurality of compounds are used for carrying out N-terminal modification on a polypeptide sequence consisting of 20 natural amino acids, so that a novel antibacterial peptide with a bionic function is generated, and the designed bionic antibacterial peptide is screened by adopting a method based on deep learning and experimental interaction. Compared with traditional drug screening, consumed time, manpower, material resources and financial resources are greatly reduced, the designed novel bionic antibacterial peptide has good biocompatibility, a functional group modified at the N end of the novel bionic antibacterial peptide can activate the self-assembly activity of polypeptide and help the polypeptide target a bacterial membrane, bacterial drug resistance is not likely to be caused, and the novel bionic antibacterial peptide has good application prospects. The drug-resistant bacteria can be effectively killed, the sterilization speed is higher, and potential and wide application prospects are achieved in clinical treatment of bacteria and drug-resistant bacteria infection diseases.

The invention provides milk exosome composite hydrogel as well as a preparation method and application thereof, and belongs to the technical field of medical materials. The milk exosome composite hydrogel provided by the invention is prepared from milk exosome, hyaluronic acid, epsilon-polylysine, 3-aminophenylboronic acid and tannic acid. The exosome is extracted from milk of a non-stem cell source; the molecular weight of the hyaluronic acid is 200 to 400 KDa. The invention provides a hydrogel carrier capable of loading a large amount of milk exosomes, and the hydrogel carrier can continuously release a large amount of milk exosomes and can give full play to the anti-oxidation and inflammation inhibition effects of the milk exosomes. In the aspect of wound healing, the milk exosome and the hydrogel carrier have a synergistic effect, so that the healing effect can be remarkably improved, and the healing period is shortened.

The invention provides double-crosslinking acellular matrix hydrogel as well as a preparation method and application thereof, and belongs to the technical field of hydrogel. The preparation method comprises the following steps: (1) carrying out decellularization treatment on a porcine dermal layer to obtain a decellularized porcine dermal matrix, (2) putting freeze-dried powder of the decellularized porcine dermal matrix into an acidic pepsin solution, stirring and digesting, adjusting the concentration, adding 10xPBS, adjusting the pH value to obtain a pregel solution, and carrying out freeze-drying on the pregel solution to obtain the porcine dermal matrix freeze-dried powder. (3) putting gel formed by the pre-gel solution into a tannic acid solution for cross-linking to obtain mono-cross-linked acellular matrix hydrogel; (4) smashing the mono-cross-linked acellular matrix hydrogel, and mixing the smashed mono-cross-linked acellular matrix hydrogel with a glucose oxidase solution and a ferrous ion solution with the concentration of 0.1-10mg / ml to obtain a bi-cross-linked acellular matrix hydrogel precursor; 5, the double-crosslinking acellular matrix hydrogel precursor is placed under the condition of glucose with the concentration being 10-200 mg / dl to form the double-crosslinking acellular matrix hydrogel. The hydrogel prepared through the method can achieve the balance of safety, supporting performance and degradability, and is wide in application range.

The invention relates to a targeted drug delivery carrier based on mesoporous polydopamine nanoparticles and application thereof.The targeted drug delivery carrier is galactose modified mesoporous dopamine coordinated with manganese ions, lysine is adopted in the carrier synthesis step to provide an alkaline environment needed by dopamine polymerization, the polymerization process is simplified, and the drug delivery efficiency is improved. Meanwhile, lysine can be introduced into the mesoporous polydopamine; and the drug loading capacity of the carrier is improved. The carrier gathers multifunctionality of drug delivery, tumor imaging and treatment, provides a comprehensive new method for tumor treatment, and enhances individuation and precision of treatment.

The invention belongs to the technical field of micro-nano, and particularly relates to a drug-loaded microalgae motor and a preparation method and application thereof, and the drug-loaded microalgae motor comprises a polydopamine / ferroferric oxide / chlamydomonas reinhardtii micromotor and a drug loaded on the polydopamine / ferroferric oxide / chlamydomonas reinhardtii micromotor, the drug is combined with catechol groups on the surface of polydopamine in the polydopamine / ferroferric oxide / chlamydomonas reinhardtii micromotor through covalent bonds; the medicine is an anti-cancer medicine or an anti-inflammatory medicine. The microalgae motor has the characteristics of simple preparation method, good material biocompatibility, high biodegradability and the like. The polydopamine / ferroferric oxide / chlamydomonas reinhardtii drug-loaded micromotor prepared by the invention has the characteristic of self-driving in intestinal juice, so that the polydopamine / ferroferric oxide / chlamydomonas reinhardtii drug-loaded micromotor can target an intestinal disease part under the guidance of an external magnetic field to improve the treatment effect and reduce the side effect of a drug, thereby expanding the application space of a micro-nano motor in the field of biomedicine.

The invention discloses riboflavin photodynamic antibacterial hydrogel for a diabetes wound dressing as well as preparation and application of the riboflavin photodynamic antibacterial hydrogel, and belongs to the technical field of biomedical materials. The hydrogel is prepared from carbomer 941, rhizoma bletillae polysaccharide and carboxymethyl chitosan through physical and chemical bi-crosslinking, glutaraldehyde and carboxymethyl chitosan are added to form dynamic imine bonds, and the stability and adaptability of the hydrogel are enhanced. Meanwhile, the photosensitizer riboflavin is introduced, so that the hydrogel is endowed with photodynamic sterilization characteristics, efficient antibiosis is realized, and rapid healing of diabetic wounds is promoted. The hydrogel has excellent wound environment adaptability and adhesion performance, and is suitable for complicated wound surfaces of diabetes mellitus. The successful research and development of the invention provide reference for the development of novel photodynamic wound dressings, have wide application prospects, provide better treatment choices for diabetics, and are helpful for accelerating wound healing, reducing infection risks and improving the life quality of patients.