696results about How to "Good biocompatibility" patented technology

The invention relates to a zirconia-based all-ceramic false tooth and a preparation method thereof. A core layer of the zirconia-based all-ceramic false tooth is prepared from the following components in parts by mass: 90 to 94 parts of ZrO2, 5 to 9 parts of Y2O3, 0.1 to 0.5 part of Al2O3, 0.01 to 0.5 part of Fe2O3, 0.01 to 0.5 part of Er2O3 and 0 to 0.2 part of MnO2, and a shell layer of the zirconia-based all-ceramic false tooth is prepared from the following components in parts by mass: 24.5 to 49.5 parts of CaCO3, 45 to 50 parts of SiO2, 0 to 25 parts of MgO, 0.01 to 0.5 part of Fe2O3, 0.01 to 0.5 part of Er2O3 and 0 to 0.2 part of MnO2. The preparation process comprises the following steps: performing dry pressing and isostatic pressing on raw materials of the core layer, presintering, and carving to obtain a zirconia-based false tooth biscuit; meanwhile, calcining raw materials of a shell layer, then adding deionized water, a dispersing agent and an adhesive, and carrying out ball milling and mixing to obtain calcium-magnesium-silicon-based ceramic slurry; and coating the calcium-magnesium-silicon-based ceramic slurry on the surface of the zirconium oxide-based false tooth biscuit, and sintering to obtain the zirconium oxide-based all-ceramic false tooth provided by the invention. The zirconia-based all-ceramic false tooth has good jade texture and is closer to the natural color of natural teeth.

The invention provides a hydroxytyrosol supramolecular compound and a preparation method and application thereof, and belongs to the technical field of cosmetics and biological medicine, the supramolecular compound comprises the following chemical components by mass: 0.01-10% of hydroxytyrosol, 2-45% of an amino acid compound, 2-20% of alpha hydroxy acid, 2-30% of urea, and 15-92% of water. The supramolecular compound can promote transdermal delivery of hydroxytyrosol and maintain the biological activity of hydroxytyrosol, shows high biocompatibility, and can be applied to product development in the antibacterial field, the regeneration field and the anti-aging field.

The invention relates to the technical field of biological medicines, in particular to a soluble skin-adhering microneedle for delivering an inactivated enterovirus vaccine as well as a preparation method and application of the soluble skin-adhering microneedle. Sodium hyaluronate is adopted as a film forming material to wrap an enterovirus 71 type (EV71)-coxsackie virus A16 (CA16) type bivalent inactivated vaccine antigen, and a needle body layer of the soluble microneedle is formed; the substrate layer is prepared from a pullulan material, so that the microneedle patch with a stable overall structure is formed. The technology provided by the invention is completed in a clean environment, and the vaccine patch which is qualified through sterility detection is obtained. The soluble microneedle disclosed by the invention has good antigen stability under the condition of 2-8 DEG C. In animal experiments, the microneedle is attached to the skin surface of a mouse for skin-adhering immunization, a strong immune response reaction can be induced, good immunogenicity is shown, and a novel, safe and effective vaccine delivery way is provided for prevention and control of the infantile hand-foot-and-mouth disease.

The invention belongs to the technical field of cosmetics, and particularly relates to a cosmetic delivery system based on a natural wall material, a preparation method and application. The cosmetic delivery system is of a core-shell structure, a core is a cosmetic active component, and a shell layer is a composite polymer gel network of sodium alginate, sophorolipid and cellulose. The natural polysaccharide composite wall material is green and safe, has good biocompatibility and strong compatibility with cosmetic formulas, and does not irritate the skin. The delivery system can effectively protect cosmetic active ingredients from being damaged by illumination and oxygen, and the storage stability of the active ingredients is remarkably improved; meanwhile, slow release and targeted transdermal absorption of active ingredients are realized, and the bioavailability is improved.

The invention discloses an application of engineered citrobacter freundii in fermentation synthesis of a stable body. The engineered citrobacter freundii is citrobacter freundii overexpressing a polyphosphate kinase gene Ppk1. The stable body prepared by fermenting the engineered citrobacter freundii is rich in polyphosphates and polyamines, particularly, the content of the polyamines can be up to 21wt%, the polyphosphates in the stable body can store the polyamines in an ionic bond combination mode, the combined polyamines are insoluble in water, a natural anion coating is generated, and the stability of the stable body is improved. And the sustained-release tablet is not easily taken by intestinal epithelial cells, so that the sustained-release tablet has a certain sustained-release effect. The medicine prepared by taking the compound as a main active ingredient shows a remarkable curative effect in ulcerative colitis treatment, has the comprehensive effects of reducing oxidative stress, enhancing the anti-inflammatory ability of a body and regulating immunity, is suitable for patients of all ages, and has outstanding application value and market prospect.

The invention relates to the technical field of antibacterial materials, and provides a light-enzyme-heat synergistic antibacterial nano composite material and a preparation method thereof.The preparation method comprises the steps that 1, a copper-based chalcogenide with a plasma resonance effect serves as a structural template, a transition metal oxide intermediate layer and a bismuth oxyhalide epitaxial layer are sequentially constructed on the surface of the copper-based chalcogenide with the plasma resonance effect through a step-by-step continuous solvothermal method, and the copper-based chalcogenide with the plasma resonance effect serves as the structural template; forming a core-shell heterojunction with Z-type energy band matching; (2) pre-assembling a natural enzyme and a monatomic nano-enzyme in a buffer system to form a composite catalytic unit with an electron transfer channel; and (3) by taking the core-shell heterojunction as a polymerization core, under the precise temperature control condition of 0-10 DEG C, initiating active free radical polymerization through an interface, constructing a thermal response polymer shell layer on the surface of the heterojunction, and encapsulating the composite catalytic unit in a functional microdomain of a polymer network in situ. The anti-bacterial fabric can achieve a better synergistic anti-bacterial effect.

The invention discloses a carnosine targeting a IIB type activin receptor and a preparation method and application of the carnosine, and the amino acid sequence of the carnosine targeting the IIB type activin receptor is as shown in SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3. The value of the equilibrium dissociation constant KD of the carnosine and the IIB type activin receptor ranges from 0.514 [mu] M to 1.91 [mu] M. The method disclosed by the invention adopts a multi-technology integration strategy of in vitro digestion simulation, mass spectrum identification, molecular docking, affinity verification and cell function experiment, and has the advantages of high efficiency and strong targeting property. The invention also aims to provide application of the carnosine in preparation of functional food or medicines for preventing and / or treating sarcopenia and promoting muscle growth.

This invention discloses a method for preparing and applying a fully biomass-based hemoperfusion adsorbent material, belonging to the field of functional polymer materials. The preparation method includes the following steps: preparing regenerated cellulose microspheres from a cellulose solution using a sol-gel conversion method; mixing the obtained regenerated cellulose microspheres with a phase change lysozyme solution and then incubating to obtain phase change lysozyme-coated regenerated cellulose microspheres, which is the fully biomass-based hemoperfusion adsorbent material of this invention. The phase change lysozyme coating of cellulose in this invention not only improves the biocompatibility of the cellulose adsorbent material but also significantly enhances its adsorption capacity for bilirubin. The fully biomass-based hemoperfusion adsorbent material of this invention can be used as a bilirubin adsorbent for hemoperfusion adsorption of bilirubin in blood.

The application relates to a human blood volume in-vitro calculation method based on a magnetic tracer, and relates to the fields of biomedical engineering and quantum sensing technology.The method comprises the following steps: obtaining blood samples of a subject before and after the subject is introduced with a known mass magnetic tracer as baseline blood samples and to-be-detected blood samples; performing homogenization pretreatment on the blood samples to prevent red blood cell sedimentation; collecting baseline magnetic signals and mixed magnetic signals by using high-sensitivity magnetic sensors, and obtaining net magnetic signals through differential operation; substituting the net magnetic signals into a homologous matrix standard curve to inversely calculate the tracer concentration; and calculating the blood volume according to the dilution law.The application adopts the magnetic tracer to replace the radioactive isotope, and combines the quantum magnetic sensing technology, so that the application has the advantages of no radioactivity, high safety, portability of equipment, low cost, repeatable measurement and the like, and is suitable for bed-side rapid detection of the blood volume.

The application relates to a double-channel near-infrared two-region rare earth nanometer probe and a preparation method and application thereof. The double-channel near-infrared two-region rare earth nanometer probe comprises a probe A and a probe B; the probe A and the probe B are both three-layer structures, and sequentially comprise a core layer, a shell layer and a hydrophilic coating layer from inside to outside; in the probe A, the core layer material is NaYF4:Er, and the shell layer material is NaYF4; in the probe B, the core layer material is NaYbF4:Ce,Er,Zn, and the shell layer material is NaYF4. The probe has the characteristics of 808 nm / 940 nm orthogonal excitation and 1532 nm narrow-band emission, has the advantages of high light stability, rapid metabolism and high biocompatibility, and can realize deep tissue high signal-to-noise ratio in-vivo imaging.

This invention relates to the field of electrochemical technology, and particularly to a single-atom nickel-modified electrode material, its preparation method, and a reactor. An embodiment of this invention provides a method for preparing a single-atom nickel-modified electrode material, comprising: S1, subjecting a carbon felt to a surface hydrophilic treatment to obtain a hydrophilic carbon felt; S2, immersing the hydrophilic carbon felt in a first solution containing Ni ions, and adding a second solution containing organic matter, allowing for a complete reaction, and then growing a nickel-containing metal-organic framework material in situ on the hydrophilic carbon felt; S3, calcining the hydrophilic carbon felt containing the nickel-containing metal-organic framework material to obtain the single-atom nickel-modified electrode material. This invention provides a single-atom nickel-modified electrode material, its preparation method, and a reactor, which can provide a cathode material that combines efficient microbial colonization with interfacial stability.

This invention discloses a ferroelectric-based teeth whitening material, its preparation method, and its application, belonging to the field of teeth whitening technology. The preparation method of the ferroelectric-based teeth whitening material includes the following steps: S1. Sodium alginate, gelatin, and water are mixed to obtain a first mixed solution; S2. 2,2,3,3,4,4-hexafluoropentane-1,5-diol is added to the first mixed solution, and the mixture is mixed again to obtain a second mixed solution; S3. The second mixed solution is allowed to stand at low temperature, then immersed in a calcium ion aqueous solution for cross-linking and curing to obtain the ferroelectric-based teeth whitening material. The teeth whitening material of this invention enables HFPD molecular crystals to remain stable in a clean water environment for teeth whitening, resulting in excellent teeth whitening effects. The HFPD molecular hydrogel prepared by this invention can achieve a high efficiency degradation of over 95% of indigo carmine within 25 minutes without polarization treatment, with a piezoelectric catalytic reaction rate constant of 0.132 min. ‑1 .

The application discloses a liquid metal-based shape-insensitive flexible conductive fabric and a preparation method and application thereof. The preparation method comprises the following steps: preparing a thermoplastic polyurethane elastomer (TPU) fiber pad and a liquid metal (LM) microsphere solution; uniformly depositing and trapping the LM microspheres in the pores of the TPU fiber pad through vacuum filtration; and hot-pressing the TPU fiber pad filled with the LM microspheres to make the LM microspheres break and fuse, so that a continuous conductive path is formed, and a flexible conductive fabric is obtained. The conductive fabric takes the TPU fiber pad as a flexible skeleton, and provides good deformation and recovery capacity; the LM is a conductive filler, and has excellent conductivity and fluidity. When various deformations such as stretching, bending, compression and twisting occur, the LM can deform synchronously with the TPU fiber skeleton and does not leak, and has good shape-insensitive conductivity. The conductive fabric can be applied to the fields of flexible high-conductive electrodes, flexible circuits, electromyographic signal monitoring, electrocardiographic signal monitoring and heat management.

This invention discloses a Pickering emulsion based on silk fibroin self-assembled particles and its preparation method. The preparation method includes the following steps: adjusting the pH of the silk fibroin solution to 4.0-4.5, adding NaCl to a final concentration of 0.05-0.1 mol / L, mixing, and then heating to 40-50 °C and allowing it to stand at a constant temperature. Using the obtained silk fibroin self-assembled particle dispersion as the aqueous phase and vegetable oil as the oil phase, the mixture is mixed with excipients and homogenized by high-speed shearing to obtain a primary emulsion. This primary emulsion is then treated by high-pressure microfluidic jet to obtain the Pickering emulsion based on silk fibroin self-assembled particles. This method requires no chemical modification or exogenous reagents, is green and simple, and does not use organic solvents. It can prepare emulsions with high biosafety and high storage stability without emulsifiers, improving process safety and scalability, and broadening its application in the food, cosmetics, and biopharmaceutical fields.

The invention relates to a method for reducing the content of residual monomers in a polymer composition, the polymer composition, a composition capable of free radical polymerization, a polymer preparation method, a polymer and application.

A kind of vocal cord repair device based on advanced biological printing technology assisted, comprising: imaging positioning component, including endoscope imaging module and three-dimensional reconstruction processor;Surgical operating component, including glottis exposure mechanism and elephant trunk type flexible mechanical arm, glottis exposure mechanism exposes glottis to provide field of view, and mechanical arm high-precision operation;Biological repair component, including micro printing head, compatible hydrogel, injection tube and motion control mechanism, realize vocal cord reconstruction and function recovery.Integrate biological printing component and imaging positioning component, system can accurately obtain the three-dimensional structure data of vocal cord damage area, and realize the millimeter level accurate deposition of biological material, so that the millimeter level precision of imaging positioning, micron level operation of mechanical arm and controllable printing of biological material form closed loop feedback system, improve the overall success rate of vocal cord repair, realize the leap of vocal cord repair from "empirical operation" to "precision engineering", provide safer and more effective treatment options for patients with vocal cord dysfunction.

The application discloses a preparation method of a hydrocolloid dressing for oral cavity, and relates to the technical field of medical supplies. Baicalin extract and a polyvinyl pyrrolidone solution are mixed to obtain a baicalin extract solution; chitosan fibers, hydroxymethyl cellulose and the baicalin extract solution are mixed to obtain a mixed solution; vacuum degassing: the prepared mixed solution is vacuumized, pressure is maintained, and primary degassing is performed; ultrasonic degassing: the mixed solution after primary degassing is subjected to ultrasonic degassing; static degassing: the solution after ultrasonic degassing is sealed by using a preservative film, and is subjected to secondary degassing at room temperature; a PU film is fixed in a film laying frame, the degassed mixed solution is poured into the film laying frame, and the film laying frame is placed into an air-blowing drying box to solidify and form a protective layer, so that the hydrocolloid dressing is obtained. The hydrocolloid dressing prepared by the method has good adhesion, can be used on a wound for a long time, and can effectively promote the repair of damaged cells and wounds, so that the healing of the wound in the oral cavity is promoted.

The application provides an antibacterial neural electrode based on a high-surface-potential zirconium oxide layer and a preparation method thereof. The electrode comprises, from bottom to top, a bottom zirconium oxide film layer, a first insulating layer, a metal layer, a second insulating layer, a top zirconium oxide film layer and an electrode modification layer. A distal end of the metal layer is partially exposed to form an electrode point, and the electrode modification layer covers the electrode point. The bottom zirconium oxide film layer and the top zirconium oxide film layer are subjected to high-surface-potential treatment and exhibit a positive surface potential in a physiological environment. The positive surface potential can destroy the cell membranes of bacteria with negative charges through electrostatic action after the neural electrode is implanted in vivo, and inhibit the formation of microglial cells and astrocytes. The damage to the membranes of mammalian cells (such as neurons) with neutral electricity is extremely small. The application realizes active antibacterial function through the high-surface-potential zirconium oxide film layer, ensures long-term effective contact between the electrode and neurons, and thus realizes high-quality, long-term stable electrophysiological recording and stimulation function of the neural electrode.

The invention belongs to the technical field of exosome preparation, and discloses a plant exosome with an anti-acne effect and a preparation method and application of the plant exosome with the anti-acne effect. According to the application, an integrated technical route of microbial regulation and induction, complexing-agent-free green extraction and synergistic acne resistance is established: a microbial strain spore suspension is used as a biological inducer, a plant active precursor is released by dynamic countercurrent of ethanol, and PEG / CaCl2 residues are completely eradicated through physical separation in the whole process; finally, the microorganism-induced plant exosome with high yield, high activity and high safety is obtained.

The present application relates to the technical field of skin external agent, in particular to a kind of regulating sensitive skin oil function composition and application thereof, the composition is composed of chrysopridine extract, fructo-oligosaccharide, carrier;The chrysopridine extract 0.005%-0.5wt%, fructo-oligosaccharide 0.02%-7wt%, the rest is carrier.This application explores the efficacy of chrysopridine extract, and finds that chrysopridine extract can promote the colonization of beneficial bacteria in microecological regulation, and by matching fructo-oligosaccharide, not only significantly improve the colonization number of beneficial bacteria, but also reduce the adhesion of harmful bacteria, with the function of bidirectional regulation of microecology;In addition, the present application can play different skin care effects by matching chrysopridine extract and fructo-oligosaccharide for different positions of face, has obvious oil control effect in T zone prone to secrete oil, the oil control effect is weak in U zone prone to dry, but has good moisturizing effect.The present application can provide convenient and fast care products for consumers with mixed sensitive skin.

The application discloses a mural reinforcing protective agent and a preparation method and application thereof, belongs to the technical field of cultural relic restoration, and can solve the technical problems that existing mural reinforcing materials cannot reinforce the lower layer structure of ancient murals and are prone to being attached to the surface of murals to cause the whitening of the surface pigments. The mural reinforcing protective agent comprises a bacterial cellulose carrier and Ba(OH)2 nanoparticles loaded on the bacterial cellulose carrier in situ. The application plays a reinforcing role on the lower layer structure of murals, realizes deep reinforcement of ancient murals, improves the protection effect, stability and durability, and the surface of the mural will not be whitened.

The application discloses a liquid droplet fusion microfluidic method based on a liquid droplet fusion microfluidic device regulated by focused surface acoustic waves, and the device comprises an interdigital transducer, two focusing arc electrodes arranged on the interdigital transducer, and a microfluid channel system bonded on the upper part of the interdigital transducer. The focusing arc electrodes are matched with the microfluid channel system, and the microfluid channel system is provided with a first collection outlet joint, a first dispersed phase inlet joint, a continuous phase inlet joint, a second dispersed phase inlet joint and a second collection outlet joint. The focusing surface acoustic waves generated by the interdigital transducer and the liquid droplet microfluid channel structure are used to flexibly realize the fusion control of liquid droplets with different sizes in the microfluid channel. The symmetrical structure is adopted to enhance the durability and repeatability of the microfluid device. The method is not only suitable for the fusion control between microdroplets, but also suitable for the fusion control between microbubbles and between microdroplets and microbubbles. The surface acoustic waves are non-contact and have good biological compatibility, and thus meet the needs of the liquid droplet fusion technology in the fields of biochemistry and medical treatment.

This application discloses an embedded whole-cell biosensor, its fabrication method, and its application in machine learning-assisted mercury ion detection, belonging to the field of sensor materials and detection technology. This sensor encapsulates *E. coli* expressing green fluorescent protein (GFP) in a polyacrylamide / hyaluronic acid (PAAM / HA) hydrogel matrix, enabling highly selective and sensitive detection of mercury ions. It effectively eliminates interference from competing metal ions and can be completely regenerated through EDTA-2Na treatment, allowing for repeated use without performance loss. It maintains a stable fluorescence response for up to three weeks, possesses excellent biocompatibility and biodegradability, minimizing the risk of secondary contamination, and facilitates rapid on-site analysis.

This invention relates to the field of oral care products technology, specifically to an artificial enzyme with antibacterial properties, its preparation method, and its application. This technical solution employs a chemical reduction method, where a palladium source reacts in an environment containing surfactants and reducing agents to obtain palladium nanozymes. The obtained palladium nanozymes exhibit uniform morphology, controllable particle size, good dispersibility in water, and good biocompatibility; they have no significant toxic side effects on human gingival fibroblasts, possess highly efficient catalase activity, and demonstrate strong antibacterial and bactericidal effects against oral pathogens, significantly reducing bacterial drug resistance; they can inhibit acid production by oral bacteria, preventing tooth decay; and they retain their original catalytic activity even after multiple cycles of use. Applying the palladium nanozymes of this solution to the manufacture of oral care products can solve the technical problems of unsatisfactory safety and easy development of drug resistance in existing oral care products using antibacterial and anti-caries methods, showing promising application prospects.

The application belongs to the field of medical materials, and particularly relates to a metal core enhanced double-barrier piezoelectric nano system and a preparation method and application thereof. The preparation method comprises the following steps: first, a core-shell structure of'metal@mesoporous titanium dioxide@mesoporous barium titanate' is prepared through a step-by-step reaction, and then the target nanoparticles are obtained through lipid wrapping. The system innovatively constructs a double-barrier structure, can self-trigger active oxygen under a physiological pressure of 4 mmHg, realizes endogenous pressure self-driven treatment of malignant ascites, has the advantages of low pressure, high catalytic efficiency, long-term structural stability and good biocompatibility, solves the problems that existing treatment methods are highly invasive and depend on exogenous stimulation, and provides a new safe and efficient technical scheme for the treatment of malignant ascites.

The application discloses a multifunctional antibacterial coating bone implant device based on a selective vacuum perfusion process and a preparation method thereof. The method comprises the following steps: 1) pretreating a titanium alloy base; 2) performing anodic oxidation treatment on the pretreated titanium alloy base to construct a nanotube structure on the surface of the titanium alloy base; 3) selectively coating the treated titanium alloy base with a hydrogel adhesive, then immersing the titanium alloy base in a povidone iodine mixed solution to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a bone growth promoting factor to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a blood vessel growth promoting factor to perform vacuum perfusion, and performing post-treatment; and 4) encapsulating the obtained sample surface with an in-situ self-polymerized polydopamine layer, washing and freeze-drying. The bone implant device has antibacterial, bone growth promoting and blood vessel growth promoting functions, and can greatly improve the curative effect on bone fracture symptoms accompanied by infection.

The application relates to the technical field of semiconductor nanomaterials, and discloses an environment-friendly zinc sulfide nanoparticle as well as a preparation method and application of the zinc sulfide nanoparticle. The preparation method comprises the following steps: (1) activating Aspergillus oryzae spores, performing liquid fermentation, filtering the liquid fermentation product, washing, collecting solid substances, and obtaining biomass; (2) culturing the biomass in the step (1) in a ZnSO4.7H2O aqueous solution to obtain an Aspergillus oryzae liquid solution containing zinc sulfide nanoparticles; (3) drying the liquid solution obtained in the step (2) to obtain Aspergillus oryzae precipitate containing zinc sulfide nanoparticles; and (4) heating the precipitate in the step (3) at 400-450 DEG C for 4-6 h to obtain zinc sulfide nanoparticles. The application endows the zinc sulfide nanoparticles with excellent biocompatibility, expands the application of the zinc sulfide nanoparticles in the fields of biomedicine, chemical sensors, solar cells and light-emitting diodes, and provides a reference for the environment-friendly and batch production of the zinc sulfide nanoparticles.

The application relates to a multifunctional spherical Prussian blue nanolaser and a preparation method and application thereof, and belongs to the field of nanobiological materials and biological medicine. The nanolaser takes spherical Prussian blue nanoparticles as a main body structure, has good near-infrared photothermal response performance and active oxygen (ROS) removal capacity, and can improve the superoxide dismutase (SOD)-like catalytic activity and antioxidant performance by doping metal elements such as ruthenium, bismuth and manganese. The nanolaser can generate a mild photothermal effect of 38-45 DEG C under near-infrared laser irradiation, and cooperatively remove excessive active oxygen in an inflammatory microenvironment, thereby reducing the expression of inflammatory factors and matrix metalloproteinases, inhibiting the activation of the iezo1 / Piezo2 / MMP13-related inflammatory and matrix degradation pathways, and relieving oxidative stress damage and inflammatory reactions. The nanolaser has the characteristics of uniform particle size, good dispersibility, high stability and excellent biocompatibility, and can be used for the prevention of diseases such as osteoarthritis and rheumatoid arthritis. The application constructs a nanolaser system with mild photothermal regulation and antioxidant activity.

The present application relates to the field of luminescent material, in particular to an aggregation-induced emission fluorescent dye with targeting function and a preparation method thereof. The dye provided in the present application has good biocompatibility and complete water solubility, and can be applied to superfast no-wash low phototoxicity imaging of living cells, greatly helping the biological research related to living cells.

The application discloses a kind of sustainable oxygen production sonodynamic therapy nanoparticles, including core-shell structure, the core of core-shell structure is located in shell inside, the core of core-shell structure is manganese oxide nanoparticle, the shell of core-shell structure is the high molecular polymer of carrying sound sensitizer, manganese dioxide nanoparticle is manganese dioxide nanoparticle, sound sensitizer is one of porphyrin and its derivatives, high molecular polymer is polylactic acid glycolic acid copolymer, this kind of sustainable oxygen production sonodynamic therapy nanoparticles by using high molecular polymer simultaneously carrying manganese dioxide nanoparticle and sound sensitizer to enhance SDT effect, high molecular polymer has good biocompatibility and drug controlled release performance, not only can reduce the toxicity of manganese dioxide to normal tissue, can also make it continuously controllable with tumor site excess H2O2 Reaction generates oxygen, reverses tumor hypoxic microenvironment while providing sufficient oxygen for SDT, under the action of ultrasound, generate a large amount of ROS to inhibit tumor.