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837results about How to "Good biocompatibility" patented technology

Carboxymethyl chitosan / oxidized sodium alginate self-crosslinking antibacterial hydrogel material

The invention discloses a self-crosslinking antibacterial hydrogel material containing carboxymethyl chitosan/oxidized sodium alginate. The material is made from the following components by mass percent: 1-35% of carboxymethyl chitosan, 1-25% of oxidized sodium alginate, 0.01-0.5% of nano-silver and distilled water. The material is prepared by the following steps: preparing the carboxymethyl chitosan by a carboxymethylation reaction of chitosan at the temperature of 10-80 DEG C; preparing the oxidized sodium alginate by an oxidation reaction of sodium alginate at the temperature of 10-45 DEG C; respectively preparing aqueous solution of the carboxymethyl chitosan and aqueous solution of the oxidized sodium alginate; adding the nano-silver solution and blending at certain ratio; and allowing self-crosslinking of the components at the temperature of 10-50 DEG C to produce the antibacterial hydrogel material. The antibacterial hydrogel material has the advantages of low cost, environmental protection, simple process and the like; as the carboxymethyl chitosan has good biocompatibility, the oxidized sodium alginate is nontoxic to human body, and the nano-silver has excellent antibacterial property, the obtained material can be applied to wound dressing, hemostatic materials and the like.
Owner:WUHAN UNIV OF TECH

Hollow core-shell nanometer mesoporous medicament carrying system with magnetism and luminescent performance, preparation method and application thereof

The invention discloses a hollow core-shell nanometer mesoporous medicament carrying system with magnetism and luminescent performance. In the medicament carrying system, a magnetic Fe3O4 hollow capsule is used as an inner core, mesoporous SiO2 is used as a shell layer, and an organic luminescent material and a biocompatible polymer are modified on the outer surface of the shell layer. A preparation method of the medicament carrying system comprises the following steps of: firstly, preparing monodisperse fusiform beta-FeOOH nanoparticles by a hydro-thermal method, coating mesoporous silicon dioxide on the surfaces of the nanoparticles, removing a pore-forming agent through thermal treatment, and simultaneously, converting the inner core into alpha-Fe2O3 from the beta-FeOOH, so that a cavity is generated in the inner core so as to form a hollow nanometer capsule structure; secondly, converting the inner core into the magnetic Fe3O4 hollow capsule through reduction treatment; and finally, modifying the organic luminescent material and the biocompatible polymer on the surface of the magnetic mesoporous nanometer capsule. The nanometer composite capsule of the invention has the advantages of core-shell structure and cavity structure, uniform particle size, high biocompatibility and excellent magnetism.
Owner:中国科学院上海硅酸盐研究所苏州研究院

Flexible temperature sensor based on graphene nanometer wall and preparing method thereof

The invention relates to a flexible temperature sensor based on a graphene nanometer wall and a preparing method thereof. The temperature sensor comprises polymer and a graphene nanometer wall body. The polymer is combined to the lower surface of the graphene nanometer wall body or embedded in the upper surface of the graphene nanometer wall body. The preparing method comprises the steps that after the graphene nanometer wall body made of the tubular CVD is transferred through the polymer transferring method, a graphene nanometer wall body/polymer double-layer structure is formed, the two ends of the graphene nanometer wall body are connected through a silver paste coating method to serve as an electrode with silver or other metal wires, spin coating can be carried out on upper layer of polymer, and a polymer/graphene nanometer wall/polymer three-layer structure is formed. The temperature sensor made of the graphene nanometer wall/polymer has the advantages of being simple in structure, convenient to machine, high in flexibility, light in weight, good in flexibility and biology compatibility and the like, and has very good application prospects in the fields of instruments, meters, photoelectric devices, flexible electronic skins and the like.
Owner:CHONGQING INST OF GREEN & INTELLIGENT TECH CHINESE ACADEMY OF SCI

Preparation method of polysaccharide-nanometer bacterial cellulose composite wound dressing

Belonging to the field of biomedical materials, the invention relates to a preparation method of a polysaccharide-nanometer bacterial cellulose composite wound dressing. The method specifically consists of the steps of: taking a nanometer bacterial cellulose membrane for pretreatment and purification treatment so as to obtain purified nanometer bacterial cellulose, then preparing a polysaccharide solution with a concentration of 0.1-10%, removing part of water from the nanometer bacterial cellulose membrane, then compounding it with a polysaccharide solution by means of soaking, tape casting or spraying so as to obtain a polysaccharide-nanometer bacterial cellulose composite membrane, then conducting extrusion dewatering and ionizing radiation disinfection, thus obtaining the polysaccharide-nanometer bacterial cellulose composite wound dressing. The dressing of the invention has the advantages of good biocompatibility, cellular affinity and antibacterial property as well as mechanical property, excellent permeability, breathability or drainage, and moisture absorption effects, and has the efficacy of sterilization, inflammation diminishing, hemostasis, pain relieving, infection reduction and the like. At the same time, the dressing can promote wound surface drying, incrustation and healing, and can be used to treat burns or scalds, open wounds, ulcers, chronic wounds and stubborn infected wound surfaces, etc.
Owner:UNIV OF SCI & TECH BEIJING

ph and oxidation-reduction dual-sensitive layer cross-linking nanoparticle as well as preparation method and application thereof

The invention relates to a pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle as well as a preparation method and an application thereof. A hydrophilic layer which at least contains PCB (Polycarboxylate Betaine) or PEG (Polyethylene Glycol) is positioned on the surface of the nanoparticle, a hydrophobic nuclei which at least contains a pH-sensitive polymer unit is positioned in the nanoparticle, and an S-S (Disulfide Bond) cross-linking layer which is formed through cross-linking reaction between PDS (Polymethacrylamide Ehtylpyridine Disulfide) units is positioned between the hydrophilic layer and the hydrophobic nuclei. A tumor targeted group can be modified on the hydrophilic layer positioned on the surface of the pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle, and the gathering of the nanoparticle on a tumor tissue and the endocytosis of the nanoparticle on the tumor cell are accelerated through the specific targeted effect of the nanoparticle on a tumor cell. The pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle disclosed by the invention has the advantages of good biocompatibility and low toxicity. According to the pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle, a cross-linked structure is dissociated under the action of glutathione inside the tumor cell, so that the release of a medicine is promoted. The preparation method disclosed by the invention is simple, convenient, good in stability and conveniently operated and popularized.
Owner:天津渤化讯创科技有限公司

Collagen/chitosan micro-nano fiber composite hemostatic membrane material and preparation method thereof

The invention discloses a collagen/chitosan micro-nano fiber composite hemostatic membrane material and a preparation method thereof. The preparation method is characterized by comprising the following steps of: extracting a medical biological skin sheet serving as a raw material by an ultrasonic technology to prepare I type collagen; mixing hexafluoroisopropanol and acetic acid according to different volume ratios to prepare a spinning solvent; mixing the prepared I type collagen and chitosan in a certain mass ratio and adding the mixture into the spinning solvent; stirring in an ultrasonic cleaner at room temperature until the material is transparent to prepare electrostatic spinning mother liquid at the concentration of 4 to 10 percent; injecting the electrostatic spinning mother liquid into an electrostatic spinning machine and performing electrostatic spinning to obtain a collagen/chitosan micro-nano fiber composite membrane; soaking the collagen/chitosan micro-nano fiber composite membrane into natural biomacromolecules and Chinese herbal medicines sequentially; and freeze-drying to obtain the collagen/chitosan micro-nano fiber composite hemostatic membrane material. The collagen/chitosan micro-nano fiber composite hemostatic membrane material has excellent biocompatibility, biodegradability, adhesion property and the like, can quickly stop bleeding, resist inflammation, ease pain and promote wound healing, and can be applied to trauma hemostasis and repair and general civil hemostasis emergency treatment.
Owner:SICHUAN UNIV

Preparation method of biological active glass/chitosan composite porous support material

InactiveCN101642589AGood biocompatibilityHigh apparent porosityProsthesisChemistrySol-gel
The invention discloses a preparation method of biological active glass/chitosan composite porous support material, which adopts a perfusion method to compound chitosan and sol-gel biological glass porous support material prepared by a foam impregnation method. The invention comprises the steps of preparing pure biological active glass support material through the foam impregnation method, preparing chitosan solution and compounding biological active glass/chitosan composite support through the perfusion method, wherein the preparation of pure biological active glass support material through the foam impregnation method comprises preparation of size of the biological active glass, selection, impregnation and desiccation of polyurethane foam template.. During the preparation process of theinvention, shape, porosity and distribution of aperture are easy to be regulated and controlled. The prepared support material is provided with three-dimensional reticulate backbone structure, and themechanical intensity, biocompatibility and bioactivity thereof are excellent and degradable; the pressure strength thereof can achieve 1.15-1.30 MPa; apparent porosity can achieve 70%-80%. The support material is capable of meeting the requirements of providing support for defective parts of tissue. The invention has simple and practical method, thus being easy for large-scale production.
Owner:SOUTH CHINA UNIV OF TECH

Biological functionalized nano titanium material and preparation method thereof

InactiveCN102058904AGood biocompatibilityImprove osseointegration performanceSurface reaction electrolytic coatingProsthesisGrowth cellNanotube array
The invention belongs to the field of biomedical materials, and relates to a biological functionalized nano titanium material. The surface of the titanium material is provided with a TiO2 nano tube array with tube diameter of 30-100nm, and the surface of the TiO2 nano tube array is also fixed with a bone morphogenetic protein 2(BMP2). A preparation method of the biological functionalized nano titanium material comprises the steps of: preparing the TiO2 nano tube array with the tube diameter of 30-100nm on the surface of the titanium material by adopting an anode oxidizing method, and fixing the BMP2 on the surface of the TiO2 nano tube array through polydopamine to obtain the biological functionalized nano titanium material. The biological functionalized nano titanium material has better biocompatibility; on one hand, the TiO2 nano tube array with proper tube diameter can provide a proper topological structure for the cell growth, on the other hand, the BMP2 is used as a growth factor capable of promoting the cell differentiation, and the proliferation and differentiation capacity of the cells on the surface of the titanium material can be improved through the synergistic effect of the topological structure and the chemical components, thus the osseointegration of the titanium material is improved.
Owner:CHONGQING UNIV
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