131 results about "Aneurysm" patented technology

The invention discloses a rigidity self-adaptive intravascular stent based on a three-dimensional virtual woven structure and a control method thereof. The method comprises the steps of reconstructing a preoperative tumor blood vessel three-dimensional model based on clinical iconography data, constructing a stent initialization model, starting a hexagonal knitting three-dimensional virtual algorithm, performing intravascular stent knitting modeling, realizing structural parameter optimization and adaptive stent expansion in combination with preoperative image data of a patient, and completing personalized deployment. The wire winding angle and the mesh density of each area of the stent are adjustable, the stent is adaptive to the complex intracranial aneurysm blood vessel form, accurate fitting and risk guiding are achieved, the treatment effect is improved, the postoperative complication risk is reduced, and the stent has good engineering suitability and clinical application prospects.

An orientable intravascular device having a “twelve o'clock” marker on a proximal and distal end for treating an aneurysm, including a packaging catheter with an identical fixed non-round shaped inner lumen, a pusher wire having an occlusion device releasably disposed on the distal end of said pusher wire, preloaded at a fixed circumferential orientation, with corresponding markers on the outside of said packaging catheter, a hub having an inner lumen that is shaped to marry with the outer lumen of the packaging catheter to deliver a delivery wire and occlusion stent in a predicted orientation, and maintaining such orientation as the wire and stent are advanced through said delivery catheter, and while said delivery catheter is withdrawn. Methods of using same are disclosed.

Provided in the present invention are a covered stent and a delivery system. The covered stent comprises a main stent having a tubular main body and an embedded stent. The main stent comprises a proximal section, an aneurysm sac section and a distal section in the axial direction. The aneurysm sac section comprises a first channel and a second channel which are arranged in the radial direction, the second channel communicating with the distal section, and the first channel being provided with an opening at the distal end and being internally provided with the embedded stent. The provision of the embedded stent provides a channel for implantation of an internal iliac artery stent, so as to enable the internal iliac artery stent to have better anchoring performance, wherein the total scaffolding strength of the first channel and the embedded stent is smaller than that of the second channel, and since the second channel has the higher scaffolding strength, the first channel deforms before the second channel when the covered stent is subjected to compression, so as to enable the second channel to keep a better channel form, thereby preventing compression-induced occlusion and ensuring blood to smoothly pass through the second channel.

The invention discloses a wide-neck aneurysm mechanical release embolism spring ring device and a using method thereof, and belongs to the technical field of medical instruments. The device comprises a catheter, a catheter channel is arranged on the inner wall of the catheter, and a thrombus removal mechanism and a protection mechanism are arranged in the channel. The bolt releasing mechanism realizes quick bolt releasing of the spring ring through cooperation of a sliding shaft, a clamping plate and other parts; the protection mechanism can prevent the spring ring from being popped up accidentally due to the fact that the releasing wire falls accidentally. When in use, the catheter is pushed to a cerebrovascular segment where an aneurysm is located under the guidance of X-ray fluoroscopy and a contrast agent, a proper spring ring is selected and pushed to a preset position, the spring ring is released through a series of operations to complete embolism, and the catheter is withdrawn after the position is determined to be stable. The problems that when a spring ring is released through traditional electrolytic fusing, the position is difficult to adjust accurately, the packing effect is affected, and the recurrence risk is increased are solved, the spring ring can be released rapidly and accurately, an operation can be completed in time, and the operation risk is reduced.

Occlusive devices and associated methods of manufacturing are disclosed herein. Manufacturing an occlusive device can include conforming a mesh to a forming assembly and setting a shape of the mesh based on the forming assembly. In some embodiments, the forming assembly comprises multiple forming members, a mandrel, and / or one or more coupling elements. The method may include everting the mesh over the forming assembly such that the mesh encloses an open volume with a shape based, at least in part, on the shape of the forming assembly. According to some embodiments, setting a shape of the mesh comprises heat-treating the mesh and forming assembly.

The present invention relates to the use of selective aquaporin inhibitors, e.g., of aquaporin-4 or aquaporin-2, e.g., certain phenylbenzamide compounds, for the prophylaxis, treatment and control of aquaporin-mediated conditions, e.g., diseases of water imbalance, for example edema (particularly edema of the brain and spinal cord, e.g., following trauma or ischemic stroke, as well as the edema associated with glioma, meningitis, acute mountain sickness, epileptic seizures, infections, metabolic disorders, hypoxia, water intoxication, hepatic failure, hepatic encephalopathy, diabetic ketoacidosis, abscess, eclampsia, Creutzfeldt-Jakob disease, and lupus cerebritis, as well as edema consequent to microgravity and / or radiation exposure, as well as edema consequent to invasive central nervous system procedures, e.g., neurosurgery, endovascular clot removal, spinal tap, aneurysm repair, or deep brain stimulation, as well as retinal edema), as well as hyponatremia and excess fluid retention, and diseases such as epilepsy, retinal ischemia and other diseases of the eye associated with abnormalities in intraocular pressure and / or tissue hydration, myocardial ischemia, myocardial ischemia / reperfusion injury, myocardial infarction, myocardial hypoxia, congestive heart failure, sepsis, and neuromyelitis optica, as well as migraines, as well as to novel assays for identifying aquaporin inhibitors.

Devices, systems, and methods for treating aneurysms are disclosed herein. According to some embodiments, the present technology includes a treatment system comprising a delivery shaft, a manipulation shaft slidably positioned within the lumen of the delivery shaft, and an occlusive device configured for implantation within the aneurysm. The occlusive device can comprise a plurality of filaments that are secured to one another at a proximal end of the occlusive device by a cured material. The occlusive device can comprise inner and outer layers of braided filaments, wherein the proximal end region of the inner layer has an exposed portion that extends proximally beyond the proximal end region of the outer layer, and wherein the cured material extends into and fills interstices between the braided filaments at the proximal end regions of the inner and outer layers.

The invention relates to the technical field of medical instruments for treating aneurysm, and particularly discloses a vascular spring ring and a coating preparation process thereof. The preparation process of the coating of the vascular spring ring comprises the following steps: S1, taking a tungsten filament, and cleaning the tungsten filament; and S2, the tungsten filament is etched through ion plating. And S3, the surface of the tungsten filament is cleaned through titanium ions, a titanium layer is deposited on the surface of the tungsten filament, and the thickness of the titanium layer is 0.015-0.025 microns. And S4, a gold layer is deposited on the surface of the titanium layer, the thickness of the gold layer is 0.15-0.25 [mu] m, and the raw material wire is obtained. And S5, the raw material wire is manufactured and formed, and the vascular spring ring is obtained. In the process, the tungsten filament is etched through ion plating, so that the surface roughness is improved, and the adhesive force of a subsequent coating is enhanced. And titanium ion cleaning is carried out, and ion plating etching residues are removed. And the thin titanium layer enhances the adhesive force of the pure gold layer. Due to the outermost gold layer, the vascular spring ring has good biocompatibility and corrosion resistance.

Systems and methods for treating an aneurysm in accordance with embodiments of the present technology include intravascularly delivering an occlusive member to an aneurysm cavity and deforming a shape of the occlusive member via introduction of an embolic element to a space between the occlusive member and an inner surface of the aneurysm wall.

The present disclosure relates generally to methods of utilizing sonosensitizers in the presence of thiamine or a derivative thereof for the purpose of cross-linking animal tissue, producing singlet oxygen within or at the site of animal tissue, or treating a condition in a subject, wherein the condition is an aneurysm, cancer, and / or a scleral condition.

The invention relates to a medical device for treating aneurysms, in particular a stent, including a compressible and expandable grid structure made up of grid elements. The grid structure has at least one closed cell ring which includes at most 12, in particular at most 10, in particular at most 8, in particular at most 6 cells directly adjacent to one another in a circumferential direction of the grid structure. The grid structure is provided at least in certain portions with a covering made of an electrospun fabric which has pores of irregular sizes. The covering includes over a surface area of 100 000 μm2 at least 10 pores which have a size of at least 15 μm2. The covering has a biocompatible, in particular antithrombogenic and / or endothelialization-promoting coating.

This invention proposes an aneurysm image segmentation method, a rupture risk prediction method, and a system. It constructs a 3D deep learning framework combining multi-view convolution and Laplacian feature pyramids. The multi-view convolution module models the 3D aneurysm structural features from multiple orthogonal directions, and a gated Laplacian frequency fusion mechanism is introduced to compensate for the loss of high-frequency detail information during downsampling, thereby improving the ability to characterize small vessels and complex boundary regions. Furthermore, the morphological features obtained from segmentation, the deep visual features of CTA images, and patient clinical information are jointly modeled. A cross-attention mechanism is used to achieve effective interaction between morphological semantics and image features, thereby completing a binary classification prediction of aneurysm rupture risk. This invention helps to fully explore the complementarity between imaging information and clinical features, more closely reflecting real clinical diagnosis and treatment processes.

The invention discloses an MMP-9-targeted MRI (Magnetic Resonance Imaging) nanoprobe and a preparation method and application thereof, the MMP-9-targeted MRI nanoprobe is represented by Gd-ACC-MAP and comprises amorphous calcium carbonate and an aptamer covalently connected to the surface of the amorphous calcium carbonate, the calcium carbonate is doped with gadolinium, and the aptamer has a nucleotide sequence as shown in SEQ ID NO: 1. The MRI nanoprobe can be used for early diagnosis of aneurysm and evaluation of rupture risk of the aneurysm.

Provided herein are compositions for use in forming temporary occlusion of a target site and methods of making same. The compositions disclosed herein include rare-earth phosphates compositions for temporary occlusion of a target sites. The compositions can be used in a variety of medical indications, such as trauma, ambulatory transport, to prevent and / or control bleeding (e.g., organ bleeding, gastrointestinal bleeding, vascular bleeding, bleeding associated with an aneurysm, etc.).

Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The implant may include a cavity in a proximal section that may optionally house embolic material, such as coils. Alternatively, the implant may have an expanded preset shape that is different than an expanded preset shape that is assumed after deployment in an aneurysm. The expanded preset shape may be frustoconical. Alternatively, the implant may include an outer skirt coupled to a proximal section of the permeable implant.

The invention discloses a method and a system for predicting an aneurysm wall enhancement area based on hemodynamic parameters. The method comprises the following steps: acquiring a TOF-MRA image and carrying out segmentation optimization; the triangular patch grids are processed, and hemodynamic parameters are extracted; determining a tumor wall enhancement state matched with each space node on the surface of the aneurysm and prediction features influencing AWE distribution; a mapping relation model of the hemodynamic parameters and AWE is constructed, and a corresponding tumor wall enhancement state value M is calculated; analyzing the tumor wall enhancement state value M matched with each space node on the surface of the predicted aneurysm to obtain a point-level enhancement prediction distribution map; detecting a connected region of the point-level enhanced prediction distribution diagram and calculating an area; and determining and outputting an aneurysm wall enhancement state and effective enhancement area space distribution. By analyzing the correlation between the hemodynamic parameters and the aneurysm wall enhancement, efficient prediction of the aneurysm wall enhancement is realized, and the accuracy of clinical diagnosis is guaranteed.

Devices for treating vascular defects and associated systems and methods are disclosed herein. In some embodiments, an occlusive device for treating an aneurysm includes an anchor structure extending circumferentially around an opening. A plurality of spiral struts are coupled to the anchor structure and extend over the opening, and a plurality of protrusions extend away from the spiral struts. The spiral struts and the protrusions can both be arranged within a common plane when the occlusive device is in an expanded configuration. When the occlusive device is deployed within the aneurysm and in the expanded configuration, the spiral struts can span the neck of the aneurysm, and the anchor structure can engage the wall of the aneurysm near the neck.

This invention relates to the field of medical device technology and discloses an embolization coil assembly. The embolization coil assembly includes a coil and a release assembly. A connecting rod is connected to the proximal end of the coil, and a clamp is connected to the proximal end of the connecting rod. The release assembly includes a tube body and a release element. The release element includes at least two jaws arranged circumferentially along the tube body, with the proximal ends of all jaws interconnected. Through holes are formed on the jaws along the radial direction of the tube body. The release element has a clamped state inside the tube body and a released state outside the tube body. When the release element is in the clamped state, at least two jaws can clamp the connecting rod, and the clamp at least partially extends into the through hole. When the release element is in the released state, the distal ends of the jaws move away from each other to release the clamp and connecting rod. This invention achieves mechanical release of the coil, preventing displacement of the coil located within the aneurysm and avoiding incorrect release of the coil, thus ensuring treatment effectiveness and surgical safety.

Medical device (10) for the treatment of vascular lesions, in particular aneurysms (100), comprising a compressible and expandable support structure (11) which is at least partially covered with an electrospun membrane (13), wherein - the support structure comprises several zigzag or wave-shaped wires (12), each forming a circumferential section (16) of the support structure (11), wherein at least 50%, in particular 100%, of the wires (12) have a radiopaque core material (14) and a superelastic sheath material (15), or - the support structure comprises a zigzag or wave-shaped wire (12) which is wound helically in a longitudinal direction of the support structure (11) and has a radiopaque core material (14) and a superelastic sheath material (15).

Embodiments perform autonomous deep learning morphology analysis. At least one image, e.g., a medical image, associated with a patient is obtained. The obtained at least one image is processed using an autonomous deep learning model to extract at least one morphological parameter associated with a suspected pathology of the patient. Based on the at least one morphological parameter, an output analysis is generated. Computer-automated detection of and morphology characterization of aneurysms are provided in embodiments.

The present application relates to the field of medical devices, in particular to an aneurysm occlusion device and a preparation method thereof, the aneurysm occlusion device comprises a mesh woven structure occlusion device body, the both ends of the mesh woven structure are respectively formed with a first bunching part and a second bunching part, the free end of the woven wire bundle of at least one of the first bunching part and the second bunching part is towards the inside of the mesh woven structure, the aneurysm occlusion device is further provided with a distal end imaging mark and a proximal end imaging mark, and the distal end imaging mark and the proximal end imaging mark are respectively arranged in the first bunching part and the second bunching part. The aneurysm occlusion device of the present application has high metal coverage, can effectively reduce the compression of the implanted device to the aneurysm and the interference to the blood flow in the aneurysm cavity, and is beneficial to the rapid endothelialization of cells.

The present disclosure discloses a method, electronic device, and storage medium for simulating coil placement in an aneurysm. The method includes: obtaining a coil model, a three-dimensional rigid body model, and an aneurysm model, wherein the coil model is a non-rigid body model; compressing the coil model using the three-dimensional rigid body model; placing the compressed coil model into the aneurysm model so that the coil model deforms under its own internal force; and obtaining a final simulation result in response to the deformation parameters of the coil model meeting a preset condition. Through the solution of the embodiment of the present disclosure, it is possible to impose constraints on the non-rigid coil model through the three-dimensional rigid body model, and use the internal force of the coil model itself to achieve expansion deformation in the aneurysm model, thereby directly simulating the coil compression and placement process quickly through physical methods, which can improve the simulation speed and have higher clinical value for emergency clinical scenarios.

The utility model relates to the technical field of medical instruments, in particular to a self-expanding intratumoral embolism device capable of being rotatably connected, which comprises an embolism device, the embolism device is formed by weaving metal wires with shape memory ability and good elasticity in a staggered manner, the embolism device comprises an anchoring part, a blocking part and a drainage part, and a lantern ring is further arranged at the bottom of the embolism device. The sleeve ring is used for being connected with the conveying device, the conveying device, the conveying device and the embolism device are connected through a rotating structure, the conveying device is used for conveying the embolism device into the aneurysm, and the conveying device comprises a conveying pipe. According to the device, the position of the embolism device in the aneurysm can be flexibly adjusted, the ball of the rotating structure freely rotates in the spherical groove of the conveying device, accurate control over the embolism device is achieved, it is ensured that the embolism device can be accurately released to the optimal position of the aneurysm, and the embolism treatment effect is remarkably improved.

The application discloses a multi-section dense net stent assembly, which comprises a lead-in sheath, the lead-in sheath is composed of an outer sheath and an inner sheath, an annular channel is formed between the outer sheath and the inner sheath, a main body stent is pressed in the annular channel, and a secondary body stent is pressed in the inner sheath; an outer layer guide wire is arranged in the lead-in sheath, a pushing block is fixed on the outer layer guide wire, the pushing block is located in the annular channel and slides, and the pushing block is connected with the inner sheath; and an inner layer guide wire is arranged in the lead-in sheath and connected with the secondary body stent, and is used for pushing the secondary body stent to slide in the inner sheath. The main body stent slides through the annular channel, the inner layer guide wire controls the main body stent, the outer layer guide wire controls the secondary body stent, the relative position between the main body stent and the secondary body stent is adjusted, the main body stent is released first, the secondary body stent is released after being aligned with an aneurysm opening, the stent is easy to be aligned with the aneurysm opening, and the operation difficulty is reduced.

The invention belongs to the technical field of medical instruments for treating aneurysm, and particularly relates to a turbulent flow device and a using method thereof.The turbulent flow device comprises an elastic supporting piece, the top end of the elastic supporting piece is fixedly connected with a head end small net disc through a head end developing ring, and the bottom end of the elastic supporting piece is fixedly connected with a tumor diameter opening large net disc through a tail end developing ring; the outer side of the middle of the elastic supporting piece is fixedly connected with a macromolecule supporting bundle, and the outer diameter of the macromolecule supporting bundle is matched with the outer diameter of the head end small net disc and the outer diameter of the tumor diameter opening large net disc. The tail end developing ring is fixedly connected with one end of an electrolysis wire, and the other end of the electrolysis wire is fixedly connected with a push rod. According to the turbulent flow device, good anchoring capacity can be achieved, the height of the turbulent flow device can be adjusted according to the tumor height, and the polymer bundles fixed to the middle elastic supporting piece improve the embolism effect at the same time, so that the purposes of rapidly embolism and preventing blood from impacting the inner wall of a tumor cavity are achieved.

Devices for treating vascular defects and associated systems and methods are disclosed herein. In some embodiments, an occlusive device for treating an aneurysm includes an expandable mesh configured to span a neck of the aneurysm. The expandable mesh can include an upper wall and a lower wall. The occlusive device can also include an insert positioned within the expandable mesh between the upper and lower walls. The insert can have an inner surface and an outer surface. The inner surface of the insert can face the upper wall of the expandable mesh, and the outer surface of the insert can face the lower wall of the expandable mesh. The insert can be configured to promote thrombosis when the occlusive device is deployed within the aneurysm.

A method for generating a coil shape according to one embodiment comprises the steps of: acquiring three-dimensional data including an aneurysm region; acquiring a first image obtained by imaging a coil in a blood vessel at a first position by using a first camera; acquiring a second image obtained by imaging the coil at a second position by using a second camera; acquiring a third image obtained by imaging the coil at a third position by using the first camera; acquiring a fourth image obtained by imaging the coil at a fourth position by using the second camera; and determining a three-dimensional coil shape on the basis of the three-dimensional data, the first image, the second image, the third image, and the fourth image.

The utility model relates to a non-contact type multifunctional neurosurgery brain cotton and gelatin sponge transfer tray which comprises an upper tray and a lower tray which can be combined, a hollow cylinder is arranged at one corner of the upper tray, a pin hole column matched with the hollow cylinder through a pin shaft is arranged at one corner of the lower tray, a plurality of partition plates are arranged in the upper tray, and the partition plates are arranged in the lower tray. The upper tray is divided into a plurality of brain cotton storage areas through the partition plates, and a downward-concave circular groove used for storing an aneurysm temporary clip is formed in the lower tray. The utility model designs a double-layer opening and closing type handheld tray which can be opened in a fan-shaped manner when in use. Four kinds of brain cotton of different sizes and models can be placed on the first layer, and meanwhile brain cotton threads can be stretched and cannot be wound mutually; gelatin sponges with different sizes and models can be placed on the second layer, and an aneurysm temporary clip can be placed on the circular sunken part. When a doctor uses the device, a nurse can deliver the brain cotton and the gelatin sponge at the same time, delivery time is saved, and the device is of great significance in dealing with cerebral hemorrhage in an emergency.