204 results about "Intravascular stent" patented technology

The invention provides a conveying system and a medical instrument. The delivery system includes a handle body, a branch channel establishment assembly, and a bundle diameter adjustment assembly. And the bending degree of the deformable part in the second state is greater than that of the deformable part in the first state. The compression degree of the intravascular stent in the fourth state is smaller than that of the intravascular stent in the third state. The deformable part can move in the axial direction of the handle body so that the far end of the deformable part can move to the open window of the intravascular stent, and the deformable part in the second state can stretch out of the open window. According to the intravascular stent, the branch channel establishing assembly and the beam diameter adjusting assembly are matched with each other, when the intravascular stent is in the fourth state, the deformable part in the second state extends out of the open window, and the branch channel is accurately established, so that the accuracy of the branch channel is improved, and the treatment effect is improved.

The invention relates to the field of biomedical materials, discloses a hydrogen sulfide / nitric oxide synergistic anti-inflammatory and anti-coagulation repair promoting coating as well as a preparation method and application thereof, and provides a coating with anti-inflammatory, anti-coagulation and tissue repair promoting functions through the synergistic effect of hydrogen sulfide and nitric oxide. The coating comprises a hydrogen sulfide donor which can spontaneously release hydrogen sulfide or a precursor thereof or release hydrogen sulfide under external stimulation; the coating further comprises a component capable of catalyzing the release of nitric oxide from the endogenous nitric oxide donor. The coating is covalently connected with the surface of a base material through a chemical means to form firm interface bonding; and the coating has a multi-cross-linked network structure, so that the coating is endowed with good stability, and long-term functional application of the coating on the surface of a biomedical material is ensured. The method can be widely applied to surface modification of biomedical materials, especially coating functionalization of implanted instruments such as valve clips, intravascular stents, heart valves, occluders, vascular grafts and myocardial patches.

The invention relates to an intravascular stent auxiliary windowing method, device and system, computer equipment, a storage medium and a computer program product. The intravascular stent auxiliary windowing method comprises the following steps: constructing a first intravascular stent model based on a three-dimensional image of a blood vessel; displaying the first intravascular stent model on a first intravascular stent object in an overlapping manner; a virtual window hole contour in a preset circumferential range on the first intravascular stent model forms a mapping contour on the first intravascular stent real object, and the mapping contour is used for assisting in forming a windowing mark on the first intravascular stent real object; and rotation information is acquired, so that the first intravascular stent model and the first intravascular stent real object can synchronously rotate based on the rotation information. According to the method, the requirement for precise punching in a large range in the circumferential direction of the first intravascular stent can be met, and punching assistance in multiple positions in the circumferential direction of the first intravascular stent is achieved.

The invention discloses a high-performance zinc alloy with a gradient structure and a preparation method and application thereof, and belongs to the technical field of metal material processing. The high-performance zinc alloy with the gradient structure is characterized in that the grain sizes of upper, middle and lower areas of the alloy are in fine-coarse-fine distribution, the grain sizes of the upper and lower areas are smaller than or equal to 2 microns, the grain size of the central area is 5-20 microns, and the grain size of a transition area between the upper and lower areas and the central area is 2-15 microns; meanwhile, all the areas are accompanied with MnZn13 nano precipitated phases with the size smaller than or equal to 50 nm. The alloy shows excellent deformation resistance and thermal mechanical stability, the elasticity modulus of the alloy can at least reach 125 GPa, meanwhile, the alloy shows excellent corrosion resistance, and the alloy is particularly suitable for biomedical implantation instruments such as intravascular stents and bone nails.

The invention relates to the technical field of medical instruments, in particular to a balloon delivery microcatheter and a using method thereof.The microcatheter comprises a handle, a balloon delivery pipe, a balloon delivery pipe and a balloon delivery pipe, the catheter body is connected with the handle, and the catheter body sequentially comprises a near-end tube, a balloon tube and a far-end tube from near to far; wherein the catheter body is of a double-cavity structure and comprises an inner cavity and an outer cavity, the inner cavity is a channel, one end of the inner cavity is communicated with the first connector, and the other end of the inner cavity penetrates to the end of the far-end tube and is used for conveying instruments, therapeutic drugs or diagnostic radiography liquid; one end of the outer cavity is communicated with the second connector, the other end of the outer cavity is communicated with the balloon tube, and the outer cavity is used for filling and pressure relief of the balloon tube. The balloon catheter has the functions of a micro catheter and a balloon catheter, a near-end blood vessel can be blocked, temporary blocking of local blood flow is achieved, the balloon catheter is further used for expanding the position, not attached to the wall, of an intravascular stent, the stent can be better attached to the blood vessel wall, and therefore pain and risks of a patient are reduced.

The invention discloses a shape memory intravascular stent capable of body temperature recovery and a preparation method thereof, and the preparation method comprises the following steps: drying polylactic acid granules, adding PEG for toughening, carrying out melt blending, adding polylactic acid fibers as a reinforcing phase, and carrying out screw extrusion to obtain a composite material. The toughness of the shape memory material is improved, the shape recovery temperature of the shape memory material is reduced, and shape recovery under the human body temperature is achieved. The intravascular stent is prepared through 3D printing, and the prepared shape memory intravascular stent has good recovery rate and fixation rate, lower recovery temperature and good biocompatibility.

The invention relates to the technical field of medical instruments, in particular to a flexibly-used multi-branch intravascular stent which comprises a stent body and a blood vessel bridle, the stent body comprises a first main blood vessel, a second main blood vessel, a first branch, a second branch, a third branch, a fourth branch and a supporting ring, and an opening in the upper end of the first branch is a free movable end; an upper port of the second branch is a free movable port, an upper port of the third branch is a free movable port, one end of the fourth branch is a free movable port, and a near-end opening of the first main blood vessel is a free movable end; the far end of the first main blood vessel is communicated with the near end of the second main blood vessel; a flange edge is annularly arranged on the outer side wall of the far end of the first main blood vessel, and a supporting ring is annularly arranged on the outer side wall of the near end of the second main blood vessel. By means of operation, the time of profound hypothermia circulation arrest is greatly shortened, brain damage and organ damage to a patient are reduced, the application range of the intravascular stent assembly is expanded, and the intravascular stent assembly can be better matched with branch blood vessels of the patient.

The invention relates to the technical field of cardiovascular stents, in particular to an alloy cardiovascular stent and a surface coating process thereof. The preparation method comprises the following steps: performing electrolytic polishing, washing and drying on a magnesium alloy intravascular stent, immersing the magnesium alloy intravascular stent into a sodium hydroxide solution for alkali heat treatment, and washing and drying to obtain a pretreated magnesium alloy intravascular stent; immersing the pretreated magnesium alloy intravascular stent into a dopamine solution for reaction to obtain a polydopamine modified magnesium alloy intravascular stent; preparing a polymer coating on the surface of the polydopamine modified magnesium alloy intravascular stent by using a physical spraying method to obtain a polymer modified magnesium alloy intravascular stent; and immersing the polymer modified magnesium alloy intravascular stent into the nanoparticle solution, and carrying out ultraviolet irradiation, washing and drying to obtain the polymer modified magnesium alloy intravascular stent. The corrosion resistance of the magnesium alloy intravascular stent is improved, the degradation rate of the stent in vivo is effectively reduced, and the stent surface is endowed with good biocompatibility.

The invention discloses a method for preparing a non-polymer coating of a pure magnesium intravascular stent, and relates to the technical field of medical instruments, and the method comprises the following steps: pretreatment: immersing the pure magnesium intravascular stent into a diluted hydrochloric acid solution for ultrasonic cleaning, removing a surface oxidation film and impurities, then washing the pure magnesium intravascular stent with deionized water until the pure magnesium intravascular stent is neutral, and drying the pure magnesium intravascular stent for later use; micro-arc oxidation: taking the pretreated bracket as an anode, taking a stainless steel plate as a cathode, putting the bracket and the stainless steel plate in electrolyte, applying pulse voltage for treatment, and generating a ceramic oxide layer with the thickness of 5-20 microns on the surface of the bracket; and bioactive coating: immersing the stent subjected to micro-arc oxidation into the suspension, and depositing by adopting an electrophoretic deposition method to form a hydroxyapatite coating with the thickness of 1-5 microns. According to the non-polymer coating method for the pure magnesium intravascular stent, no polymer is used in the whole coating process, inflammatory reaction possibly caused by the polymer and degradation products of the polymer is avoided, and the biological safety of the stent is improved.

A device for therapeutic ablative treatment of residual plaque on, in, and / or surrounding a stent within a blood vessel of a subject includes a jacket configured for insertion within a stent within a blood vessel of a subject. The device further includes an ultrasound transducer located within the jacket and having at least one active element oriented to deliver ultrasound energy in a radial and / or axial direction of the jacket from within the stent to ablate the residual plaque.

The invention relates to an endovascular stent comprising a tubular expandable lattice structure comprising a plurality of negative Poisson' s ratio (NPR) cells in connection with at least one row of positive Poisson's ratio (PPR) cells provided along a length of the stent. Each NPR cell may have a shape of a re-entrant (RE) hexagon. The stent may be automatically bent after expansion. The invention also relates to an endovascular stent graft comprising the endovascular stent and a liner provided around the endovascular stent.

The invention discloses a magnesium alloy corrosion resistance prediction method based on machine learning, and relates to the technical field of metal material performance prediction.The method comprises the following steps that magnesium alloy corrosion resistance data are obtained and preprocessed, and a magnesium alloy data set is obtained; aiming at a random forest algorithm and a gradient boosting tree algorithm, training, optimizing and evaluating the prediction model by using the magnesium alloy data set to obtain an optimal prediction model; and for the optimal prediction model, inputting components and environmental parameters of the magnesium alloy, and outputting a corrosion resistance prediction value. According to the method, the prediction precision and the material design efficiency can be remarkably improved, the method is suitable for biomedical application of orthopedic implants, intravascular stents and the like, and an efficient and reliable technical path is provided for research and development of the degradable magnesium alloy.

The invention relates to the technical field of medical instruments, and discloses a carotid artery micro-net woven stent. The stent comprises a stent main body divided into a stent middle part and a stent end part, the stent main body comprises a first stent, a second stent and a plurality of connecting structures, and the first stent and the second stent are both in a hollow pipe shape and are connected with each other through the connecting structures; the first support and the second support are connected at multiple positions through a plurality of connecting structures, so that movement of the first support and the second support can be limited, and the connecting structures comprise the first connecting structure and the second connecting structure. The two different connecting structures are arranged on the stent body, so that the requirement for different slippage degrees of the ends and the middle is met, layers of the intravascular stent are attached during use, the structural integrity of the stent is kept, the stent is tightly attached to a blood vessel, and good supporting and effective covering are achieved.

The invention belongs to the technical field of intravascular stents, and particularly discloses a degradable peripheral artery stent, the cross section of the degradable peripheral artery stent is of an annular structure, the degradable peripheral artery stent is applied to the peripheral artery of the human body and comprises a plurality of supporting units and connecting units in the axial direction of the stent, the connecting units are located between the supporting units, and the adjacent supporting units are connected through the connecting units; the supporting unit comprises an end supporting unit and a middle supporting unit, and the end supporting unit and the middle supporting unit are each of a closed-loop structure formed by intersecting a sine-like curve and a reverse sine-like curve. The stent is integrally formed through a 3D printing technology, and is high in structural stability and good in flexibility. According to the degradable peripheral artery stent of the structure, degradable polylactic acid is adopted as a stent material, inflammatory reaction caused by the fact that the stent exists in blood vessels for a long time is greatly avoided, and the stent has good flexibility and adherence performance under the condition that the stent has enough radial supporting force; and the risk of restenosis after the stent operation is reduced.

The invention discloses a fucoidin-bioactive peptide coated intravascular stent and a preparation method thereof, and belongs to the technical field of medical treatment. The surface of the fucoidin-bioactive peptide coating intravascular stent is coated with a composite coating, and the composite coating is composed of fucoidin and bioactive peptide. The invention discloses a fucoidin-bioactive peptide coated intravascular stent and a preparation method thereof, and the fucoidin-bioactive peptide coated intravascular stent not only solves the problems of poor blood compatibility and slow endothelialization, but also has multiple functions of anticoagulation, anti-proliferation and repair promotion. The intravascular stent coating technology is comprehensively upgraded, and a safer, more effective and more lasting solution is provided for treatment of cardiovascular diseases.

The invention discloses a long-section peripheral vascular stent which is used for treating diseases such as peripheral vascular stenosis below knees and the like and solves the problems that an existing stent is difficult to introduce into peripheral blood vessels and lacks effective support. The stent has two states of a pressing and holding state and an expansion state with different section radiuses, is implanted into a peripheral vascular affected part in the pressing and holding state, and supports a blood vessel at the affected part in the expansion state. Sufficient radial yield strength is provided through a plurality of supporting rings so as to adapt to the characteristics that the peripheral blood vessel is large in elasticity and thick in outer base layer. And the stent is prepared from a degradable material, so that mechanical support required in the early stage of fusion is met, the stent also has relatively high strength and toughness, and the stent can be degraded in vivo, so that the use safety is greatly improved. Moreover, the pattern of the stent is optimized, so that the circumferential rotation phenomenon of the longer intravascular stent in the expansion process is improved, and the damage to the vascular wall in the implantation process is reduced to the greatest extent.

The invention provides a self-expanding hydrogel intravascular stent and a preparation method thereof, and belongs to the technical field of medical instruments, the intravascular stent is of a hollow tubular structure, and the tube wall is of a sealed type; the intravascular stent is made of a hydrogel material. After the hydrogel stent shrinks, the size of the hydrogel stent is obviously reduced, the hydrogel stent can be delivered to a target position in a balloon intervention mode, and the hydrogel stent can stay at the target position and provide a supporting effect on the hydrogel stent due to the fact that the hydrogel stent has a self-expansion effect.

The invention discloses a passive brain-computer interface system based on an intravascular stent. The passive brain-computer interface system comprises at least one extensible intravascular stent, a charging module, a brain signal receiving module and a brain signal analysis module, the expandable intravascular stent comprises a stent net, an intracranial physiological signal detection module, a wireless charging module, a wireless communication module and a stent circuit, the wireless charging module is used for receiving a wireless charging signal sent by the charging module and providing a power supply signal according to the wireless charging signal; the brain signal receiving module is used for sending a received brain signal to the brain signal analysis module; and the brain signal analysis module is used for obtaining an analysis result according to the brain signal. According to the embodiment of the invention, an intracranial electroencephalogram signal can be collected in a low-risk manner.

The invention provides a conveying device. The conveying device comprises a main stent conveying pipe and a multi-cavity pipe. The main stent conveying pipe is used for conveying an intravascular stent, and a branch opening is formed in the intravascular stent; the multi-cavity tube comprises a plurality of cavities, the cavities have different axial lengths, the preset guide wire is preset in at least one branch opening, and the multi-cavity tube can reach the branch opening along the preset guide wire to establish a passage from the branch opening to the branch blood vessel. According to the conveying device, the intravascular stent can be conveyed only through the lower limb admission passage, the intravascular stent does not need to be conveyed from the upper limb admission passage, and damage to healthy blood vessels is reduced.

The invention relates to the technical field of medical instruments, in particular to an intravascular stent. According to the specific technical scheme, the intravascular stent comprises a stent skeleton, after the stent skeleton is subjected to surface treatment, at least one layer of film covering section is arranged outside the stent skeleton, and medicine release sections are arranged at the two ends of the stent skeleton. The problems that in the drug release process of an existing stent, the drug release rate is uneven, biocompatibility is poor, and thrombus and restenosis are caused by a metal stent are solved.

The invention discloses a functional coating, an intravascular stent and a preparation method and application of the intravascular stent. The functional coating comprises an endothelialization promoting active substance and an anti-proliferation drug; the endothelialization promoting active substance comprises at least one of polypeptide containing an RGD sequence, polypeptide containing a YIGSR sequence, polypeptide containing an REDV sequence, a beta-polypeptide polymer or a beta-polypeptide-polyester block copolymer. The functional coating disclosed by the invention can be used for surface functional modification of interventional medical devices, can selectively promote adhesion and proliferation of vascular endothelial cells at an implantation part, realizes rapid endothelialization, and can controllably release an anti-proliferation drug to inhibit excessive proliferation of vascular smooth muscle cells, so that the vascular endothelial cells are prevented from being damaged. Therefore, the risks of restenosis and advanced thrombus are effectively reduced.

The invention discloses a digital twinning method for a virtual clinical test of an intravascular stent. The method comprises the following steps: obtaining a preprocessed image after segmentation and preprocessing; performing blood vessel segmentation on the preprocessed image to obtain a blood vessel segmentation image; processing the blood vessel segmentation image to obtain a preprocessed real patient blood vessel model; performing virtual blood vessel sample amplification to generate a virtual blood vessel model; a full-order CFD model is constructed, and hemodynamic parameters are obtained; training the PINN physical neural network to obtain PINN prediction data; and obtaining a preset mechanical condition. Medical images are analyzed and processed through an image processing technology, position detection, segmentation extraction, three-dimensional reconstruction and three-dimensional display of human blood vessels and diseased regions of the human blood vessels are achieved, and hemodynamic changes of specific parts are simulated through different support designs and placement.

The invention provides a biological vascular stent material and a preparation method thereof, and belongs to the technical field of biomedical materials. The polylactic acid-polyvinyl alcohol emulsion is used as a skin layer spinning solution, a sodium alginate solution containing exosomes is used as a core layer spinning solution, a composite material is prepared through a coaxial electrostatic spinning technology, and the biological vascular stent material is obtained in cooperation with a post-treatment process, so that the porosity of the material is effectively improved, and the biological vascular stent is prepared. Meanwhile, the elongation and the supporting force of the intravascular stent are increased.

The invention relates to the technical field of intravascular stents, and discloses an implantation device for an intravascular stent, the implantation device comprises a box body, the box body is provided with a disinfection mechanism, and the disinfection mechanism comprises a rotating shaft, a knob, a placement disc, a fixing rod, a rotating cylinder and a UVC sterilization lamp; the rotating shaft penetrates through the back face of the box body through a bearing, the rotary knob is fixedly connected to one end of the rotating shaft, the outer wall of the rotating shaft is fixedly sleeved with the containing disc, the fixing rod is fixedly connected to the inner wall of the box body, the rotating cylinder is rotationally connected with the fixing rod through a bearing, and the number of the UVC sterilization lamps is two. And the two UVC germicidal lamps are symmetrically arranged on the inner wall of the rotary drum. By arranging the box body and the box cover, catheters can be stored, the situation that secondary infection is caused in the transportation process, and consequently the success rate of an operation is affected is avoided, the catheters in the box body can be rapidly sterilized and disinfected by arranging the UVC sterilization lamp, and therefore the success rate of intravascular stent implantation is increased.

The utility model relates to the technical field of intravascular stents, and provides an intravascular stent which comprises a stent body, the stent body comprises a plurality of sets of wave-shaped supporting rings and a plurality of connecting rods, the connecting rods are connected between every two adjacent sets of wave-shaped supporting rings, the stent body is conical, the diameter of the first end is larger than that of the second end, and the connecting rods are arranged from the first end to the second end. The length of the unfolded waveform support rings is gradually reduced, the design of the waveform support rings not only ensures the radial strength of the stent, but also enhances the flexibility and adaptability of the stent, so that the stent can be better attached to the blood vessel wall, two adjacent sets of waveform support rings are connected through a plurality of connecting rods, and the overall stability and structural integrity of the stent are ensured. The main body of the stent is conical, so that the stent can better adapt to the physiological structural characteristics of a conical blood vessel, the gradual transition of radial supporting force of the stent at different positions is ensured, the excessive compression on the blood vessel wall is reduced, the risks of stent breakage and restenosis in the stent are reduced, and the use safety performance is improved.

The invention relates to a loader for assisting stent sheathing and a manufacturing method thereof, the loader is used for sleeving a sheathing canal, and the loader comprises a first protection section, a second protection section, a third protection section, a fourth protection section, a fifth protection section and a sixth protection section, a pipe cavity of the second protection section is conical, and the large end side of the second protection section is connected with the first protection section; the tube cavity of the loading leading-in section is conical, and the small end side of the loading leading-in section is connected with the small end side of the second protection section through a second step section; the inner diameter D4 of the protection section is larger than the maximum outer diameter D1 of the sheathing canal, and the minimum diameter D5 of the second step section is smaller than the minimum inner diameter D2 of the sheathing canal. The loader can assist the intravascular stent in entering the inner cavity of the sheathing canal, the difficulty of the stent entering the sheathing canal is reduced, the doctor labor is reduced, and the operation success rate is improved.

The invention relates to a cross-joint intravascular stent and a preparation method thereof. The cross-joint intravascular stent comprises a first part and a second part which are distributed in the axial direction of the cross-joint intravascular stent. The first part comprises a plurality of first stent rings which are arranged at intervals in the axial direction of the joint-crossing intravascular stent and are mutually independent, and a whole-surface covering film fixedly arranged on the first stent rings; from the proximal end to the distal end, the distance between every two adjacent first stent rings is gradually increased; the second part comprises a plurality of second stent rings which are arranged at intervals in the axial direction of the joint-crossing intravascular stent and are mutually independent, and a plurality of rows of connecting membrane groups which are sequentially arranged in the axial direction of the joint-crossing intravascular stent; each row of connecting membrane group comprises a plurality of connecting membranes which are uniformly distributed in the circumferential direction of the joint-crossing intravascular stent, and the two ends of each connecting membrane are fixedly connected with the two adjacent second stent rings respectively; the width of the rods forming the first stent ring is greater than the width of the rods forming the second stent ring.

The invention relates to the technical field of medical instruments, in particular to an intravascular stent conveying system and a conveying method.The intravascular stent conveying system comprises an intravascular stent and a conveying device, and the intravascular stent comprises a telescopic tube, a main tube connected with the front end of the telescopic tube and a plurality of branch tubes connected to one side of the telescopic tube; the conveying device comprises a handle assembly, a main body bending adjusting assembly, a main body releasing assembly, a branch bending adjusting assembly, a branch releasing assembly and an outer sheath assembly. The handle assembly comprises a holding handle, a supporting rod and a guide head which are connected in sequence, and the holding handle is hollow; the outer sheath assembly is arranged on the periphery of the supporting rod in a sleeving mode and located between the holding handle and the guide head. The requirement for bending adjustment during intravascular stent implantation is met, independent release of all structures of the intravascular stent is achieved, the release mode is simple and convenient, the learning curve is short, profound hypothermia circulation arrest is avoided in the whole operation process, the operation difficulty is reduced, and damage to a patient is reduced.

The invention discloses a guide wire with an intravascular stent. The guide wire comprises a guide wire body and the intravascular stent arranged on the guide wire body in a sleeving mode, and a connecting wire is arranged between the guide wire body and the intravascular stent. The guide wire comprises an inner guide wire and an outer guide wire; the inner guide wire and the outer guide wire are both of tubular structures, the outer guide wire is arranged on the outer side of the inner guide wire in a sleeving mode, and the intravascular stent is located between the inner guide wire and the outer guide wire; the connecting wire is respectively connected with the outer guide wire and the intravascular stent; an easy-to-break point is arranged in the middle of the connecting wire; a stable supporting frame is provided through the double-tube structure of the inner guide wire and the outer guide wire, the inner guide wire serves as a main guide wire and provides hardness and rigidity, accurate positioning of the guide wires in a blood vessel is guaranteed, the outer guide wire plays a protection role, the intravascular stent is prevented from making direct contact with the blood vessel wall in the positioning process, potential damage to the blood vessel is reduced, and the intravascular stent has a good application prospect. The controllability of the guide wire can be effectively improved, so that a doctor can accurately adjust the placement position of the intravascular stent, and the stability and the optimal unfolding effect of the intravascular stent are ensured.

The invention belongs to the technical field of intravascular stents, and discloses a degradable balloon stent and a preparation method thereof.The degradable balloon stent comprises a net-shaped stent body, the stent body is cylindrical, the inner side of the stent body is connected with an inflation balloon in a sleeved mode, and the inflation balloon is used for sending the stent body to an affected part and expanding the stent body; the whole outer cylindrical wall of the stent is wrapped and connected with a drug bearing layer, the drug bearing layer uniformly bears an anti-proliferation drug, and the material of the drug bearing layer is an absorbable material; wherein the medicine bearing layer is arranged to be of an expandable or contractible structure, and when the stent is expanded, the medicine bearing layer is expanded along with the stent; the problem that the occurrence rate of restenosis of positions corresponding to stent meshes is high is solved.