109 results about "Intravascular stent" patented technology

The invention relates to an intravascular stent auxiliary windowing method, device and system, computer equipment, a storage medium and a computer program product. The intravascular stent auxiliary windowing method comprises the following steps: constructing a first intravascular stent model based on a three-dimensional image of a blood vessel; displaying the first intravascular stent model on a first intravascular stent object in an overlapping manner; a virtual window hole contour in a preset circumferential range on the first intravascular stent model forms a mapping contour on the first intravascular stent real object, and the mapping contour is used for assisting in forming a windowing mark on the first intravascular stent real object; and rotation information is acquired, so that the first intravascular stent model and the first intravascular stent real object can synchronously rotate based on the rotation information. According to the method, the requirement for precise punching in a large range in the circumferential direction of the first intravascular stent can be met, and punching assistance in multiple positions in the circumferential direction of the first intravascular stent is achieved.

The invention discloses a high-performance zinc alloy with a gradient structure and a preparation method and application thereof, and belongs to the technical field of metal material processing. The high-performance zinc alloy with the gradient structure is characterized in that the grain sizes of upper, middle and lower areas of the alloy are in fine-coarse-fine distribution, the grain sizes of the upper and lower areas are smaller than or equal to 2 microns, the grain size of the central area is 5-20 microns, and the grain size of a transition area between the upper and lower areas and the central area is 2-15 microns; meanwhile, all the areas are accompanied with MnZn13 nano precipitated phases with the size smaller than or equal to 50 nm. The alloy shows excellent deformation resistance and thermal mechanical stability, the elasticity modulus of the alloy can at least reach 125 GPa, meanwhile, the alloy shows excellent corrosion resistance, and the alloy is particularly suitable for biomedical implantation instruments such as intravascular stents and bone nails.

The invention discloses a shape memory intravascular stent capable of body temperature recovery and a preparation method thereof, and the preparation method comprises the following steps: drying polylactic acid granules, adding PEG for toughening, carrying out melt blending, adding polylactic acid fibers as a reinforcing phase, and carrying out screw extrusion to obtain a composite material. The toughness of the shape memory material is improved, the shape recovery temperature of the shape memory material is reduced, and shape recovery under the human body temperature is achieved. The intravascular stent is prepared through 3D printing, and the prepared shape memory intravascular stent has good recovery rate and fixation rate, lower recovery temperature and good biocompatibility.

The invention discloses a method for preparing a non-polymer coating of a pure magnesium intravascular stent, and relates to the technical field of medical instruments, and the method comprises the following steps: pretreatment: immersing the pure magnesium intravascular stent into a diluted hydrochloric acid solution for ultrasonic cleaning, removing a surface oxidation film and impurities, then washing the pure magnesium intravascular stent with deionized water until the pure magnesium intravascular stent is neutral, and drying the pure magnesium intravascular stent for later use; micro-arc oxidation: taking the pretreated bracket as an anode, taking a stainless steel plate as a cathode, putting the bracket and the stainless steel plate in electrolyte, applying pulse voltage for treatment, and generating a ceramic oxide layer with the thickness of 5-20 microns on the surface of the bracket; and bioactive coating: immersing the stent subjected to micro-arc oxidation into the suspension, and depositing by adopting an electrophoretic deposition method to form a hydroxyapatite coating with the thickness of 1-5 microns. According to the non-polymer coating method for the pure magnesium intravascular stent, no polymer is used in the whole coating process, inflammatory reaction possibly caused by the polymer and degradation products of the polymer is avoided, and the biological safety of the stent is improved.

A device for therapeutic ablative treatment of residual plaque on, in, and / or surrounding a stent within a blood vessel of a subject includes a jacket configured for insertion within a stent within a blood vessel of a subject. The device further includes an ultrasound transducer located within the jacket and having at least one active element oriented to deliver ultrasound energy in a radial and / or axial direction of the jacket from within the stent to ablate the residual plaque.

The invention discloses a magnesium alloy corrosion resistance prediction method based on machine learning, and relates to the technical field of metal material performance prediction.The method comprises the following steps that magnesium alloy corrosion resistance data are obtained and preprocessed, and a magnesium alloy data set is obtained; aiming at a random forest algorithm and a gradient boosting tree algorithm, training, optimizing and evaluating the prediction model by using the magnesium alloy data set to obtain an optimal prediction model; and for the optimal prediction model, inputting components and environmental parameters of the magnesium alloy, and outputting a corrosion resistance prediction value. According to the method, the prediction precision and the material design efficiency can be remarkably improved, the method is suitable for biomedical application of orthopedic implants, intravascular stents and the like, and an efficient and reliable technical path is provided for research and development of the degradable magnesium alloy.

The invention relates to the technical field of medical instruments, and discloses a carotid artery micro-net woven stent. The stent comprises a stent main body divided into a stent middle part and a stent end part, the stent main body comprises a first stent, a second stent and a plurality of connecting structures, and the first stent and the second stent are both in a hollow pipe shape and are connected with each other through the connecting structures; the first support and the second support are connected at multiple positions through a plurality of connecting structures, so that movement of the first support and the second support can be limited, and the connecting structures comprise the first connecting structure and the second connecting structure. The two different connecting structures are arranged on the stent body, so that the requirement for different slippage degrees of the ends and the middle is met, layers of the intravascular stent are attached during use, the structural integrity of the stent is kept, the stent is tightly attached to a blood vessel, and good supporting and effective covering are achieved.

The invention discloses a fucoidin-bioactive peptide coated intravascular stent and a preparation method thereof, and belongs to the technical field of medical treatment. The surface of the fucoidin-bioactive peptide coating intravascular stent is coated with a composite coating, and the composite coating is composed of fucoidin and bioactive peptide. The invention discloses a fucoidin-bioactive peptide coated intravascular stent and a preparation method thereof, and the fucoidin-bioactive peptide coated intravascular stent not only solves the problems of poor blood compatibility and slow endothelialization, but also has multiple functions of anticoagulation, anti-proliferation and repair promotion. The intravascular stent coating technology is comprehensively upgraded, and a safer, more effective and more lasting solution is provided for treatment of cardiovascular diseases.

The invention provides a self-expanding hydrogel intravascular stent and a preparation method thereof, and belongs to the technical field of medical instruments, the intravascular stent is of a hollow tubular structure, and the tube wall is of a sealed type; the intravascular stent is made of a hydrogel material. After the hydrogel stent shrinks, the size of the hydrogel stent is obviously reduced, the hydrogel stent can be delivered to a target position in a balloon intervention mode, and the hydrogel stent can stay at the target position and provide a supporting effect on the hydrogel stent due to the fact that the hydrogel stent has a self-expansion effect.

The invention provides a conveying device. The conveying device comprises a main stent conveying pipe and a multi-cavity pipe. The main stent conveying pipe is used for conveying an intravascular stent, and a branch opening is formed in the intravascular stent; the multi-cavity tube comprises a plurality of cavities, the cavities have different axial lengths, the preset guide wire is preset in at least one branch opening, and the multi-cavity tube can reach the branch opening along the preset guide wire to establish a passage from the branch opening to the branch blood vessel. According to the conveying device, the intravascular stent can be conveyed only through the lower limb admission passage, the intravascular stent does not need to be conveyed from the upper limb admission passage, and damage to healthy blood vessels is reduced.

The invention discloses a functional coating, an intravascular stent and a preparation method and application of the intravascular stent. The functional coating comprises an endothelialization promoting active substance and an anti-proliferation drug; the endothelialization promoting active substance comprises at least one of polypeptide containing an RGD sequence, polypeptide containing a YIGSR sequence, polypeptide containing an REDV sequence, a beta-polypeptide polymer or a beta-polypeptide-polyester block copolymer. The functional coating disclosed by the invention can be used for surface functional modification of interventional medical devices, can selectively promote adhesion and proliferation of vascular endothelial cells at an implantation part, realizes rapid endothelialization, and can controllably release an anti-proliferation drug to inhibit excessive proliferation of vascular smooth muscle cells, so that the vascular endothelial cells are prevented from being damaged. Therefore, the risks of restenosis and advanced thrombus are effectively reduced.

The utility model relates to the technical field of intravascular stents, and provides an intravascular stent which comprises a stent body, the stent body comprises a plurality of sets of wave-shaped supporting rings and a plurality of connecting rods, the connecting rods are connected between every two adjacent sets of wave-shaped supporting rings, the stent body is conical, the diameter of the first end is larger than that of the second end, and the connecting rods are arranged from the first end to the second end. The length of the unfolded waveform support rings is gradually reduced, the design of the waveform support rings not only ensures the radial strength of the stent, but also enhances the flexibility and adaptability of the stent, so that the stent can be better attached to the blood vessel wall, two adjacent sets of waveform support rings are connected through a plurality of connecting rods, and the overall stability and structural integrity of the stent are ensured. The main body of the stent is conical, so that the stent can better adapt to the physiological structural characteristics of a conical blood vessel, the gradual transition of radial supporting force of the stent at different positions is ensured, the excessive compression on the blood vessel wall is reduced, the risks of stent breakage and restenosis in the stent are reduced, and the use safety performance is improved.

The invention relates to a loader for assisting stent sheathing and a manufacturing method thereof, the loader is used for sleeving a sheathing canal, and the loader comprises a first protection section, a second protection section, a third protection section, a fourth protection section, a fifth protection section and a sixth protection section, a pipe cavity of the second protection section is conical, and the large end side of the second protection section is connected with the first protection section; the tube cavity of the loading leading-in section is conical, and the small end side of the loading leading-in section is connected with the small end side of the second protection section through a second step section; the inner diameter D4 of the protection section is larger than the maximum outer diameter D1 of the sheathing canal, and the minimum diameter D5 of the second step section is smaller than the minimum inner diameter D2 of the sheathing canal. The loader can assist the intravascular stent in entering the inner cavity of the sheathing canal, the difficulty of the stent entering the sheathing canal is reduced, the doctor labor is reduced, and the operation success rate is improved.

The invention relates to a cross-joint intravascular stent and a preparation method thereof. The cross-joint intravascular stent comprises a first part and a second part which are distributed in the axial direction of the cross-joint intravascular stent. The first part comprises a plurality of first stent rings which are arranged at intervals in the axial direction of the joint-crossing intravascular stent and are mutually independent, and a whole-surface covering film fixedly arranged on the first stent rings; from the proximal end to the distal end, the distance between every two adjacent first stent rings is gradually increased; the second part comprises a plurality of second stent rings which are arranged at intervals in the axial direction of the joint-crossing intravascular stent and are mutually independent, and a plurality of rows of connecting membrane groups which are sequentially arranged in the axial direction of the joint-crossing intravascular stent; each row of connecting membrane group comprises a plurality of connecting membranes which are uniformly distributed in the circumferential direction of the joint-crossing intravascular stent, and the two ends of each connecting membrane are fixedly connected with the two adjacent second stent rings respectively; the width of the rods forming the first stent ring is greater than the width of the rods forming the second stent ring.

The invention relates to the technical field of medical instruments, in particular to an intravascular stent conveying system and a conveying method.The intravascular stent conveying system comprises an intravascular stent and a conveying device, and the intravascular stent comprises a telescopic tube, a main tube connected with the front end of the telescopic tube and a plurality of branch tubes connected to one side of the telescopic tube; the conveying device comprises a handle assembly, a main body bending adjusting assembly, a main body releasing assembly, a branch bending adjusting assembly, a branch releasing assembly and an outer sheath assembly. The handle assembly comprises a holding handle, a supporting rod and a guide head which are connected in sequence, and the holding handle is hollow; the outer sheath assembly is arranged on the periphery of the supporting rod in a sleeving mode and located between the holding handle and the guide head. The requirement for bending adjustment during intravascular stent implantation is met, independent release of all structures of the intravascular stent is achieved, the release mode is simple and convenient, the learning curve is short, profound hypothermia circulation arrest is avoided in the whole operation process, the operation difficulty is reduced, and damage to a patient is reduced.

The invention discloses a guide wire with an intravascular stent. The guide wire comprises a guide wire body and the intravascular stent arranged on the guide wire body in a sleeving mode, and a connecting wire is arranged between the guide wire body and the intravascular stent. The guide wire comprises an inner guide wire and an outer guide wire; the inner guide wire and the outer guide wire are both of tubular structures, the outer guide wire is arranged on the outer side of the inner guide wire in a sleeving mode, and the intravascular stent is located between the inner guide wire and the outer guide wire; the connecting wire is respectively connected with the outer guide wire and the intravascular stent; an easy-to-break point is arranged in the middle of the connecting wire; a stable supporting frame is provided through the double-tube structure of the inner guide wire and the outer guide wire, the inner guide wire serves as a main guide wire and provides hardness and rigidity, accurate positioning of the guide wires in a blood vessel is guaranteed, the outer guide wire plays a protection role, the intravascular stent is prevented from making direct contact with the blood vessel wall in the positioning process, potential damage to the blood vessel is reduced, and the intravascular stent has a good application prospect. The controllability of the guide wire can be effectively improved, so that a doctor can accurately adjust the placement position of the intravascular stent, and the stability and the optimal unfolding effect of the intravascular stent are ensured.

The invention belongs to the technical field of intravascular stents, and discloses a degradable balloon stent and a preparation method thereof.The degradable balloon stent comprises a net-shaped stent body, the stent body is cylindrical, the inner side of the stent body is connected with an inflation balloon in a sleeved mode, and the inflation balloon is used for sending the stent body to an affected part and expanding the stent body; the whole outer cylindrical wall of the stent is wrapped and connected with a drug bearing layer, the drug bearing layer uniformly bears an anti-proliferation drug, and the material of the drug bearing layer is an absorbable material; wherein the medicine bearing layer is arranged to be of an expandable or contractible structure, and when the stent is expanded, the medicine bearing layer is expanded along with the stent; the problem that the occurrence rate of restenosis of positions corresponding to stent meshes is high is solved.

The invention provides a porous cell auxetic material, an absorbable intravascular stent, a preparation device and a preparation method, and belongs to the field of medical instruments, holes in porous cells are dumbbell-shaped structural holes, and the dumbbell-shaped structural holes are transversely and vertically alternately formed in the long axis direction and also transversely and vertically alternately formed in the short axis direction; dumbbell-shaped structure holes in a transverse and vertical alternating array are formed, and the short shafts of the dumbbell-shaped structure holes are provided with anti-springback inserting and pulling abutting supporting structures; the shape of the auxetic material during expansion is maintained, shrinkage is prevented when the auxetic material is axially compressed, and lasting supporting force is provided; when the vascular stent is formed by adopting the structure, radial and axial contraction of the vascular stent is prevented, the shape of the vascular stent is maintained, reliable radial supporting force is provided, the smoothness of the blood vessel is ensured, the mechanical performance of the biological absorbable stent is improved, the use amount of the biological absorbable polymer material is reduced, and the wall thickness is reduced.

This invention relates to an endovascular stent, comprising a first sub-stent and a second sub-stent, both woven from multiple braided filaments into a mesh-like structure; the first sub-stent and the second sub-stent are coaxially arranged; a flexible element is connected at one end to one end of the first sub-stent and at the other end to one end of the second sub-stent; the flexible element has a helical or variable-diameter helical structure; when the flexible element has a variable-diameter helical structure, the outer diameter of the flexible element gradually increases and then gradually decreases from the proximal end to the distal end; by adjusting the distance between the first sub-stent and the second sub-stent, the flexible element undergoes elastic deformation, thereby adjusting the metal coverage between the first sub-stent and the second sub-stent.

The utility model discloses an intravascular stent electrode system which comprises an intravascular stent, an electrode contact, a guide wire, a signal collecting unit and a receiving coil, the intravascular stent can be implanted into a target area of an intracranial vascular system through an operation, and the electrode contact is connected to the intravascular stent and can collect intracranial signals. The guide wire can conduct stimulation current to the electrode contact and transmit signals collected by the electrode contact, the signal collecting unit is connected with the guide wire and can collect the signals transmitted by the guide wire, and the receiving coil is arranged on the signal collecting unit and forms electromotive force through a magnetic field. The electromotive force is converted by the power supply chip and then continuously supplies power to the signal collection unit and the electrode contact, so that the stable work of the signal collection unit can be maintained.

The utility model relates to the technical field of medical instruments, and discloses an intravascular stent structure capable of reducing pressure stress, the intravascular stent is of a tubular net rack structure and comprises a plurality of annular wave rods and stent connecting rods, the annular wave rods are arranged in the axial direction of the intravascular stent, a plurality of stent connecting rods are arranged on one side of each wave rod, and the stent connecting rods are arranged on the other side of each wave rod. One end of each support connecting rod is connected with an adjacent wave rod, the section of each wave rod is arranged in a wave shape, and the support is characterized in that no less than one group of pressure stress parts capable of reducing the pressure stress of the wave rods are arranged on the side surfaces of the wave rods; due to the design of the wave-shaped wave rods and the pressure stress part, the support has more elastic deformation space, when the support is stressed, the support can elastically deform to a certain degree at the fluctuation of waves and the bending part of the pressure stress part instead of directly bearing all the pressure like a rigid structure, and the elastic deformation absorbs part of the pressure, so that the stress resistance of the support is improved. Therefore, the pressure stress is reduced.

The invention discloses an antibacterial compound containing shellac nanoparticles and a preparation method of the antibacterial compound, and belongs to the technical field of medical materials. The antibacterial product is a polylactic acid-glycolic acid copolymer (PLGA) loaded shellac nanoparticle antibacterial coating or hyaluronic acid (HA) loaded shellac nanoparticle antibacterial gel. The coating and the gel prepared by the invention have excellent antibacterial performance and good biocompatibility, and the preparation method is relatively simple. The antibacterial coating can be applied to the surfaces of medical instruments such as intravascular stents, artificial heart valves, artificial blood pumps, artificial blood vessels, catheters and vein filters to improve the antibacterial performance of the medical instruments, and can also be applied to the surfaces of skin and mucosa to improve the antibacterial performance.

The present invention relates to an internal duct and fixing system (100) for branches for endovascular endoprostheses for endovascular treatment of aneurysms or dissections of the aorta, comprising (i) an endoprosthesis (200) provided with windows (210, 220, 230, 240), (ii) one or more occlusions (215, 225, 235, 245), fixed to the endoprosthesis (200) by means of suture (216, 226, 236, 246), reversibly occluding the windows (210, 220, 230, 240), and a set of fixing and duct elements (300) that forms one or more internal channels of the endoprosthesis (200), preferably in the region adjacent to one of the windows (210, 220, 230, 240). The present invention also relates to a corresponding endoprosthesis (200).

The utility model relates to the technical field of medical instruments, and particularly discloses a guide strip of a linear cutting stitching instrument in a body cavity. The top end of the conical cap part gradually moves to form a traction rope part; through the arrangement of the traction rope part and the conical cap part, the guide strip and the conical cap are soft and elastic due to the silica gel or rubber material, so that the inlet groove can adapt to linear cutting stitching instruments of various brands and models and can be stably connected with the cutting stitching instruments of various materials, and the friction force is large; the disposable intravascular stent is simple in structure and not prone to falling off in the using process, so that the difficulty of surgical operation is reduced, damage to blood vessels and peripheral tissue is avoided, the effect of one-time successful operation can be achieved, tissue damage and time waste caused by repeated attempts to pass through gaps beside the blood vessels are avoided, accidental bleeding can be avoided, the surgical duration is shortened, and the anesthesia time of a patient is shortened.

The invention relates to the technical field of laser cutting, in particular to a medical nickel-titanium alloy intravascular stent cutting device which comprises a protection cabinet body and a laser cutting machine fixedly installed on the inner wall of the protection cabinet body, an air pump is fixedly installed on the inner wall of the protection cabinet body, and the output end of the air pump is fixedly connected with a supporting inner pipe. A plurality of chutes which are uniformly arranged are formed in the outer wall of the supporting inner pipe, a fixing frame is fixedly connected to the inner walls of the chutes, a corrugated pipe is fixedly connected to the outer wall of the fixing frame, an air spraying head is fixedly connected to the outer wall of the corrugated pipe, and a fixing piece is fixedly connected to the outer wall of the air spraying head; the device has the beneficial effects that in the reciprocating process that the air spraying head stretches and then retracts, the air spraying head can gradually incline downwards during stretching, in the process, air sprayed out of the air spraying head can sweep waste located between the inner wall of the waste nickel-titanium alloy pipe fitting and the outer wall of the supporting inner pipe from top to bottom, and therefore the waste can fall off more easily.

This invention is directed to an expandable stent for implantation in a body lumen, such as an artery, and a method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common axis and interconnected by one or more links. A Y-shaped member is comprised of a U-shaped member and a link having a curved portion and a straight portion to improve the flexibility and thereby improve the fatigue performance of the Y-link junction.

The invention belongs to the technical field of biomedical materials, and provides a poly L-lactide-caprolactone composite material, a preparation method and application thereof, and an intravascular stent. The composite material is prepared from poly L-lactide-caprolactone (PLCL) and a metal oxide (one or more of ferric oxide, magnesium oxide, zinc oxide and titanium dioxide) as preparation raw materials. Compared with PLLA, the composite material provided by the invention has better strength and toughness; the metal oxide can improve the degradation speed of the polymer PLCL. Therefore, the composite material disclosed by the invention has excellent toughness, strength and degradation speed. Furthermore, particularly when the metal oxide is ferric oxide, the elongation at break and the tensile strength of the obtained composite material are remarkably improved; in addition, the in-vitro degradation rate is also obviously improved; meanwhile, the biocompatibility is excellent.

The invention provides a separable microcatheter and stent conveying system and method, and belongs to the technical field of neural intervention and vascular intervention. The system comprises a separable micro-catheter which is formed by detachably connecting a near-section micro-catheter (1) and a far-section micro-catheter (2) through a physical clamping structure; the stent conveying system comprises a conveying guide wire (3) and an intravascular stent (4), and the conveying guide wire (3) is provided with an anchoring stent (31) matched with the limiting cavity of the far-section micro catheter (2). The guide wire, the catheter and the stent conveying system are integrated, so that the vascular interventional operation process is obviously optimized. The system adopts a separable microcatheter design and a mechanical anchoring structure, so that a guide wire and a catheter do not need to be exchanged for many times in the operation process, and the number of times of instrument operation is fundamentally reduced. According to the invention, the operation time is shortened, the exposure time of an operator and a patient under X-rays is directly reduced, and the radiation dose is effectively controlled.

A bifurcated intravascular stent graft comprises primary stent segments and a primary graft sleeve, forming a main fluid channel and having a side opening therethrough. An external graft channel formed on the primary graft sleeve has a first end communicating with the side opening and an open second end outside the primary graft sleeve, thereby providing a branch flow channel from the main channel out through the side opening and external graft channel. The primary stent segments and graft sleeve engage an endoluminal surface of a main vessel and form substantially fluid-tight seals. The stent graft further comprises a secondary stent graft, which may be positioned partially within the external graft channel, through the open second end thereof, and partially within a branch vessel. The secondary stent graft engages the inner surface of the external graft channel and the endoluminal surface of the branch vessel, thereby forming substantially fluid-tight seals.

The invention relates to a preparation method of a medical degradable Fe-Mn-Si alloy wire, which is characterized in that the Fe-Mn-Si alloy comprises the following components in percentage by mass: 20-30% of Mn, 2-5% of Si and the balance of iron; the preparation method comprises the steps that raw materials are taken according to the designed components, then vacuum induction melting and casting are conducted, an as-cast product is obtained, the as-cast product is subjected to drawing treatment after being subjected to homogenizing annealing treatment, the deformation of each pass of drawing is 0.02-0.03 mm (the diameter reduction amount), and the accumulated deformation is 22%-72%; and during homogenizing annealing treatment, the temperature is controlled to be 500-600 DEG C, and the time is 30-40 min. According to the preparation method of the medical degradable Fe-Mn-Si ternary alloy wire, the preparation method of the medical degradable Fe-Mn-Si ternary alloy wire is tried for the first time, and the medical degradable Fe-Mn-Si ternary alloy wire with excellent performance is obtained under the condition that wire breakage is avoided as far as possible through cooperation of the components and the preparation process. The wire material developed by the invention can be used as a degradable biological suture line, a degradable intravascular stent and other medical materials.