351 results about "Poly dl lactide" patented technology

A composition for delivering a tumor therapeutic agent to a patient includes a fast-release formulation of a tumor apoptosis inducing agent, a slow-release formulation of a tumor therapeutic agent, and a pharmaceutically acceptable carrier. An apoptosis-inducing agent in a pharmaceutically acceptable carrier may be administered before or concomitantly therewith. Nanoparticles or microparticles (e.g., cross-linked gelatin) of the therapeutic agent (e.g., paclitaxel) also may be used. The nanoparticles or microparticles may be coated with a bioadhesive coating. Microspheres that agglomerate to block the entrance of the lymphatic ducts of the bladder to retard clearance of the microparticles through the lymphatic system also may be employed. This invention also uses drug-loaded gelatin and poly(lactide-co-glycolide) (PLGA) nanoparticles and microparticles to target drug delivery to tumors in the peritoneal cavity, bladder tissues, and kidneys.

The present disclosed subject matter relates to methods and compositions for restoring a diseased or damaged tooth such that infection is inhibited or eliminated and pulp regeneration is facilitated. The disclosed subject matter also includes a composition comprising a physiologically acceptable matrix seeded with pulp cells. The matrix can be capable of being injected into the pulp chamber of a tooth. In some embodiments, the matrix of a composition includes a hydrogel (e.g., collagen, chitosan, alginate, MATRIGEL™, gelatin, JELL-O®, fibrin), a mesh (e.g., polylactide-coglycolide (PLGA) mesh, polylactide (PLA) mesh, or polyglycolide (PGA) mesh, a cross-linked fiber mesh, a nanofiber mesh, a mesh fabric, biodegradable polymer mesh), a microsphere (biodegradable polymer microsphere, a hydrogel microsphere), or a combination of any of the foregoing. In yet other embodiments, the matrix includes a nanofiber, an artificial three-dimensional scaffold material, or a synthetic three-dimensional scaffold material.

The present invention provides a resin composition excellent in strength, impact resistance, heat resistance and moldability and further, of low environmental load capable of decreasing CO₂ exhaustion in its production.

The present invention is a resin composition comprising a styrene-based resin (A), an aliphatic polyester (B) and at least one species selected from a compatibilizer (C) and a dicarboxylic anhydride (D), and the compatibilizer is preferably at least one species described below.

• • (C-1) methyl methacrylate polymer
  • (C-2) a vinyl-based polymer to which epoxy unit or acid anhydride unit is copolymerized
  • (C-3) a graft polymer in which methyl methacrylate unit is grafted to a rubbery polymer
  • (C-4) a block copolymer in which polylactide segment and a vinyl-based polymer segment

The present invention provides a composition comprising: (a) dielectric material; and (b) porogen comprising at least two fused aromatic rings wherein each of the fused aromatic rings has at least one alkyl substituent thereon and a bond exists between at least two of the alkyl substituents on adjacent aromatic rings. Preferably, the dielectric material is a composition comprising (a) thermosetting component comprising (1) optionally monomer of Formula I as set forth below and (2) at least one oligomer or polymer of Formula II as set forth below where Q, G, h, I, I, and w are as set forth below and (b) porogen. Preferably, the porogen is selected from the group consisting of unfunctionalized polyacenaphthylene homopolymer, functionalized polyacenaphthylene homopolymer, polyacenaphthylene copolymer, polynorbornene, polycaprolactone, poly(2-vinylnaphthalene), vinyl anthracene, polystyrene, polystyrene derivatives, polysiloxane, polyester, polyether, polyacrylate, aliphatic polycarbonate, polysulfone, polylactide, and blends thereof. The present compositions are particularly useful as dielectric substrate material in microchips, multichip modules, laminated circuit boards, and printed wiring boards.

Provided is a thermoplastic resin composition comprising 1 to 100 parts by weight of a flame retardant (B) containing any one or more flame retardants (B-1) selected from melamine phosphate, melamine pyrophosphate, and melamine polyphosphate and any one or more flame retardants (B-2) selected from piperazine phosphate, piperazine pyrophosphate, and piperazine polyphosphate, based on 100 parts by weight of a thermoplastic resin (A) comprising polylactide resin, wherein, according to transmission electronic microscopy, the major axis of the largest particle of the flame retardant (B) in the composition is not more than 10 μm, and the ratio of the number of particles of the flame retardant (B) having a major axis of not more than 3 μm relative to the number of particles of the flame retardant (B) per an area of 1,000 μm² is 70% or more.

The invention belongs to the field of medical technology, relates to a high-stability polyethylene glycol-polyester polymer and an application thereof, and particularly relates to an amphiphilic block copolymer having a hydrophilic block and a hydrophobic block with terminal hydroxyl, wherein the terminal hydroxyl of the hydrophobic block is replaced by a cholic acid group. The hydrophilic A block is any one of ethylene glycol monomethyl ether, polyethylene glycol, polyvinyl alcohol and polyvinylpyrrolidone; the hydrophobic B block is any one of polylactide, polylactide-co-glycolide, polyglycollide, polycaprolactone, polylactide-co-caprolactone, polyglycollide-co-caprolactone and polylactide-co-glycolide-cocaprolactone. The polymer provided by the invention can spontaneously form high-stability micelle in a waterborne medium, and can be used as a carrier of various water-insoluble drugs.

Resorbable polylactide polymer healing membranes and methods of their applications are disclosed. In a broad embodiment, the invention features methods for inducing proper tissue healing after an open heart surgery. In one embodiment, the methods includes a step of forming a patch with a healing membrane over the open pericardium to induce proper tissue healing and placement in other open heart surgery procedures to facilitate re-entry by the surgeon.

The invention provides a multi-block polyurethane shape memory polymer material based on lactide and 1, 4-dioxegy cyclohexanone. The polymer material takes hydroxyl terminated poly (lactide-co-1, 4-dioxegy cyclohexanone) as a soft block; a PUU chain segment or uramido chain segment product which is formed by vulcabond and bifunctional micromolecules containing active hydrogen is chosen as a hard block. The temperature of the shape memory is within 20-55 DEG C. The invention further provides the preparation method of the material. The shape memory polymer material based on lactide and 1, 4-dioxegy cyclohexanone provided by the invention integrates good odegradability, biocompatibility, high mechanical strength, flexility and the shape memory performance together. The deformation temperature of the polymer material can be adjusted to be close to human body temperature; therefore, the polymer material is applied to surgical operations or medical appliance implantation materials.

The present invention relates to a composite microsphere system comprising poly(D,L-lactide-co-glycolide) (PLGA), poly(acryloyl hydroxyethyl starch) (AcHES), and a pharmaceutically effective amount of a biologically active compound. The active compound may be, for example, an insulin, an interferon, a luteinizing hormone-releasing hormone (LHRH) analog, a somatostatin and/or derivatives thereof, a calicitonin, a parathyroid hormone (PTH), a bone morphogenic protein (BMP), an erythropoietin (EPO), an epidermal growth factor (EGF) or a growth hormone. This invention also relates to methods of using the composite microspheres, and methods of preparing same.

The present invention provides aniline oligomers, their aliphatic polyester copolymer and their preparation. Two kinds of aniline oligomers are first synthesized with N-phenyl-1, 4-p-phenylene diamine as material, and then copolymerized with aliphatic polyester to obtain electrically active biodegradable polymers. During the preparation, N-phenyl-1, 4-p-phenylene diamine has its end amido group protected with butanedioic anhydride and is then reacted with end amido aniline dimer and phenylene diamine to obtain aniline tetramer with one end carboxyl group and one end amino group and aniline pentamer with two end carboxyl groups; and the aniline oligomers are finally polycondensated with double hydroxyl group terminated aliphatic polyester to obtain the copolymers containing electrically active aniline oligomer block. The copolymers possess the advantages of both aniline oligomer and aliphatic polyester, and is used as biomedicine material mainly.

The invention relates to an anti-cancer sustained release injection containing epothilone derivative, consisting of sustained microspheres and menstruum. The sustained microspheres comprise anti-cancer drugs selected from taxane, alkylating agent and/or plant alkaloid and the like, the epothilone derivative and sustained release auxiliary material. The menstruum is a special menstruum containing suspending agent. The epothilone derivative is selected from epothilone B, epothilone D, iso-epothilone D, BMS-247550, azaepothilone B, furan epothilone D or BMS-310705. The sustained release auxiliary material is selected from poly-dl-lactide, the glycolic acid copolymer of the poly-dl-lactide, polyethyleneglycol, the polylactide copolymer of the polyethyleneglycol, carboxyl terminated polylactide copolymer, fatty acid and decanedioic acid copolymer, etc. The suspending agent is selected from carboxymethyl cellulose and the like with the viscosity of 100cp to 3000cp (under the temperature of 25 DEG C to 30 DEG C). The sustained release microsphere can also be made into a sustained release implant. The sustained release injection is injected or arranged in or around the tumour and can release drug at partial position for 40 days approximately, therefore, the sustained release injection improves the local drug concentration selectively and enhances the treatment effect of non-operative treatments, such as radiotherapy, chemotherapy and the like at the same time.

The invention relates to an anti-cancer sustained release injection containing epothilone derivative, consisting of sustained microspheres and menstruum. The sustained microspheres comprise anti-cancer drugs selected from taxane, alkylating agent and/or plant alkaloid and the like, the epothilone derivative and sustained release auxiliary material. The menstruum is a special menstruum containing suspending agent. The epothilone derivative is selected from epothilone B, epothilone D, iso-epothilone D, BMS-247550, azaepothilone B, furan epothilone D or BMS-310705. The sustained release auxiliary material is selected from poly-dl-lactide, the glycolic acid copolymer of the poly-dl-lactide, polyethyleneglycol, the polylactide copolymer of the polyethyleneglycol, carboxyl terminated polylactide copolymer, fatty acid and decanedioic acid copolymer, etc. The suspending agent is selected from carboxymethyl cellulose and the like with the viscosity of 100cp to 3000cp (under the temperature of 25 DEG C to 30 DEG C). The sustained release microsphere can also be made into a sustained release implant. The sustained release injection is injected or arranged in or around the tumour and can release drug at partial position for 40 days approximately, therefore, the sustained release injection improves the local drug concentration selectively and enhances the treatment effect of non-operative treatments, such as radiotherapy, chemotherapy and the like at the same time.

The invention discloses a regular structure multi-block biodegradable thermic shape memory polymer and a preparation method thereof. The shape memory polymer consists of a plurality of soft blocks and hard blocks which are alternately arranged. The soft blocks and the hard blocks are both copolymers and both have even chain length; the content of the hard blocks is between 50 and 90 weight percent; and the content of the soft blocks is between 10 and 50 weight percent. Each soft block is a crystalline poly(epsilon-caprolactone-glycolide)chain segment which has the fusion point 3 DEG C above a body temperature; and each hard block is a crystalline poly(L-lactide-glycolide)chain segment which has the fusion point 50 DEG C above the body temperature and a controllable deformation recovery rate. The shape memory polymer can relatively independently control the mechanical properties and the degradation rate, thereby having the mechanical properties and the controllable degradation rate matched with the implanted tissue in vivo. With good forming machining performance and excellent biocompatibility, the shape memory polymer can be used as a new functional biological medical material. The preparation method is characterized by simplicity, short reaction time, no residual harmful reagent content, and the like, thereby facilitating the commercialization.

A biodegradable shape memory polymer is prepared through synthesizing poly-L-lactide oligomer, synthesizing poly(glycolide/caprolactone) cooligomer and using diisocyanate-type coupling agent to couple them together to obtain polyblock copolymer. Its advantage is high effect to hold the thermal deformation and thermally restoring the original shape.

The present invention relates to a process for recovering lactide from polylactide (PLA) or glycolide from polyglycolide (PGA), in which, in a first step, PLA or PGA is contacted with a hydrolysing medium and hydrolytically degraded to oligomers. In a further step, a cyclising depolymerisation of the oligomers obtained in the first step is effected to give lactide or glycolide. In addition, the present invention relates to an apparatus based on the combination of a hydrolysis apparatus with a depolymerisation reactor, with which the above-described process can be performed. The core of the process according to the invention is a partial hydrolysis of the polymeric materials originally used in combination with a cyclising depolymerisation.

The invention relates to an acetate bicyclic guanidine, a synthesizing method thereof and a synthesis of a polylactide and a polyserine morpholine dione by catalysis. The acetate bicyclic guanidine has the above structure and is synthesized by a direct reaction of bicyclic guanidine and acetic acid in a catalyst-free aqueous solution. In the invention, the acetate bicyclic guanidine is adopted as a catalyst to catalyze a bulk activity of L-lactide (LLA), D,L-lactide (DLLA) or (3S)-3- benzyloxymethyl-6-methyl-morpholine dione (BMMD) to perform ring opening polymerization reaction , thereby synthesizing a poly L-lactide (PLLA) and a poly D,L-lactide (PDLLA) with a number average degree of polymerization of between 120 and 280 and narrow molecular weight distribution and polyserine morpholine dione with a number average degree of polymerization of between 120 and 150. PBMMD can be used for preparing a lactic acid-serine copolymer. The acetate bicyclic guanidine as the catalyst is a nonmetallic and nontoxic organic compound; the method has low production cost, simple process operation, no pollution, a high product yield of more than or equal to 95 percent and a high product purity of more than or equal to 98 percent; and a synthesized biodegradable polymer has high biological safety.

The invention relates to novel absorbable polyesters, produced by ring-opening polymerisation of hydroxycarboxylic acids in the presence of a polyol containing an electrolyte, in an extruder. In particular, the invention relates to novel polylactide glycolide polyesters which are essentially free of dextran sulphate and which are produced by ring-opening polymerisation of lactide and glycolide in the presence of dextran sulphate in the extruder; to the production of the same and to their use in depot medicaments.

The invention discloses a fully-biodegradable material as well as a preparation method and application thereof. The fully-biodegradable material is prepared from the following raw materials in percentage by weight: 15%-70% of polylactic acid, 20%-50% of starch, 3%-65% of a copolymer of butanediol adipate and butanediol terephthalate, 1%-10% of polylactide polyol, 0.1%-5% of a titanate coupling agent and 0-5% of an aid. The fully-biodegradable material has excellent mechanical property, can be biologically degraded and is relatively low in cost. The preparation method can be easily implemented by virtue of existing high-speed mixing equipment and double-screw extruders. The fully-biodegradable material has excellent and stable performance, can be biologically degraded, is relatively low in cost and is applicable to the fields of plastic packaging materials, agricultural plastic mulching films, disposable tableware and the like.

The invention relates to a impact-modified bio-degradable polymer composition having large particle size impact modifiers dispersed in a continuous biodegradable polymer phase. The impact modifiers have a core-shell morphology and have average sizes of greater than 250 nm. The impact-modified composition has good impact properties and low haze. The biodegradable polymer is preferably a polylactide or polyhydroxy butyrate. The composition comprises 30-99.9 weight percent of degradable polymer and 0.1 to 15 weight percent of one or more impact modifiers.

A polyethanediol-poly(lactide-caprolactone) nanoparticle carrying camptothecine is prepared from polyethanediol-poly (lactide-caprolactone) as carrier and camptothecine through self-assembling in water. Its advantages are adjustable release speed of caprolactone and high biologic utilization rate.

The invention provides a neutral restoration catheter support of a multilayer structure and manufacturing method of the neutral restoration catheter support in order to meet requirements of neural tissue engineering. The neutral restoration catheter support structurally comprises an inner pipe, a middle pipe and an outer pipe which are made of incompletely different materials, the inner pipe is made of poly-dl-lactide, the middle pipe is made of a lactic acid caprolactone copolymer, and the outer pipe is made of poly-l-lactide. The neutral catheter support is characterized in that the support has certain mechanical performance, is bendable and extrudable, is 10-15MPa in tensile strength and 5-13% of tensile deformation and can restore to an original form after being bent or extruded.

The invention relates to a polyethylene glycol-b-poly(L-lactide-co-epsilon-caprolactone)/poly (epsilon-caprolactone)-REDV blended superfine electrospun fiber film and a preparation method thereof. Poly (epsilon-caprolactone) with low molecular weight is coupled with REDV small peptides, poly (epsilon-caprolactone)-g-REDV is prepared, poly (epsilon-caprolactone)-g-REDV and polyethylene glycol-b-poly(L-lactide-co-epsilon-caprolactone) with high molecular weight are together dissolved in a mixed solvent of chloroform and N,N-dimethyl formamide, and an electrostatic spinning method is used for preparation in order to obtain the superfine fiber film. The electrospun fiber film comprises superfine fiber whose diameter is 400-1000nm, and thickness is 50-200[mu]m. The electrospun fiber film contains REDV small peptides on the surface, in order to promote adhesion and growth functions of vascular endothelial cells; at the same time, the superfine fiber film is used for wrapping and loading nucleic acid, protein, medicament and other bioactive substances, and has capability for controlled release of bioactive substances. The product is used for biomedical materials.