71 results about "Poly dl lactide" patented technology

Provided are compositions that include a histone deacetylase inhibitor (HDACi) encapsulated in and / or otherwise associated with a nanoparticle. In some embodiments, the HDACi is romidepsin, vorinostat, belinostat, panobinostat, and / or chidamide. In some embodiments, the nanoparticle is a poly(D,L-lactide)-PEG-methyl ether (mPEG-PDLLA) nanopolymer. Also provided are methods for treating diseases, disorders, and / or conditions associated with sensitivity to histone deacetylase inhibitors, such as but not limited to tumors and / or cancers; and methods for inhibiting the growth, proliferation, and / or metastasis of a tumor and / or a cancer associated with sensitivity to histone deacetylase inhibitors by administering an effective amount of a composition as disclosed herein, which methods can optionally include administering at least one additional therapeutically active agent, such as but not limited to a chemotherapeutic agent.

The present invention belongs to the technical field of patch materials and relates to a double-layer composite patch with a healing and repairing function and a preparation method thereof. The double-layer composite patch is composed of an oriented fiber layer and a random dense layer composited up and down; the components of the oriented fiber layer are synthetic polymers and natural polymers, the synthetic polymer is polylactic acid, poly (L-lactide-caprolactone) or poly (lactic acid-glycolic acid copolymer), and the natural polymer is insoluble type I collagen; during preparation, the oriented fiber membrane obtained by electrospinning is first cut and pre-tensioned and placed in a bidirectional clamping device, and then the bidirectional clamping device is placed in a vacuum oven for annealing treatment, and finally the random dense membrane obtained by electrospinning and the oriented fiber membrane after annealing treatment are composited by ultrasonic welding to obtain the double-layer composite patch. The double-layer composite patch of the present invention has both anti-inflammatory and repair functions while achieving the synergy of "exogenous efficient barrier" and "endogenous precise guidance" functions; the preparation method is simple.

Disclosed herein is a polysialic acid (PSA)-polymer conjugated compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein P is a poly (lactide-co-glycolide)-poly (ethylene glycol) copolymer (PLGA-PEG) and p is an integer from 4 to 200; nanoparticles comprising the same; and methods of treating ophthalmic diseases using the same. (I)

Symmetric Star Poly(Substituted Glycolide) Homopolymers and Their Surface Properties The invention include the synthesis, thin film formation, surface properties, and comprehensive analysis of star-shaped well-defined symmetric poly(substituted glycolide) (s-PSG) homopolymers, which are alternatives to polylactides and polyglycolides. Four-armed symmetric poly(L-diisopropyl glycolide) (4s-PLDIPG) and poly(L-diisobutyl glycolide) (4s-PLDIBG) prepared by ring opening polymerization (ROP) under melt conditions with tin (II) 2- ethylhexanoate catalyst and pentaerythritol initiator exhibited high conversions (92-98%) and desirable PDI values (1.23-1.49). The NMR data of all s-PSGs showed that the methylene peaks of pentaerythritol were shifted, proving that polymerization took place in all arms. The molecular weights (Mn NMR, Mw GPC, Mn GPC) of s-PSGs determined by NMR and GPC data were consistent with the theoretical values. By increasing the side chain length of s-PSG homopolymers, there was a consistent increase in the water contact angles and surface roughness values of the thin films, whereas the surface free energy diminished.

The application discloses a kind of high uniformity medical grade absorbable polyester, preparation method and production system, production system includes kettle type closed stirrer, auxiliary tank, three-way valve and closed kettle type reactor;Three-way valve is communicated with kettle type closed stirrer by melt metering pump;It is communicated with auxiliary tank by micro-injection pump;It is communicated with closed kettle type reactor by static mixer;The side inside of three-way valve and micro-injection pump communication side is designed funnel shape, including funnel neck and funnel mouth, the side surface and bottom surface of funnel neck are equipped with uniform small hole.The application discloses a kind of system specially used for preparing high uniformity medical grade absorbable polyester and the preparation method matched therewith, by using special production system again cooperation specific process parameter can successfully prepare with medical grade absorbable polyester, especially suitable for the preparation of poly-l-lactide and polyglycolide with higher viscosity, more difficult to produce, the product obtained has high uniformity, high molecular weight and low monomer residue.

Provided are an absorbable biomedical polymer material, a ligation clip, and a method for preparing same. The ingredients selected for the absorbable biomedical polymer material consist of a first polymer and a second polymer. The first polymer consists of 50 wt%-100 wt% of poly(L-lactide) and 0 wt%-50 wt% of polyglycolide, and the second polymer is poly(p-dioxanone). The absorbable biomedical polymer material has suitable rigidity and flexibility, and can be used in preparing a medical device, such as a ligation clip. In particular, when containing 2.5 wt%-40 wt% of the first polymer, the ligation clip can readily pierce the fascia, and is less likely to undergo plastic deformation at a bend. Also disclosed are some structural forms of ligation clips and a method for preparing same.

The invention provides a binuclear zinc complex based on a bridged bis (beta-diimine) dianion ligand as well as a preparation method and application of the binuclear zinc complex, and belongs to the technical field of preparation and application of metal organic complexes. Starting from p-phenylenediamine, an aryl bridged bis (beta-diimine) ligand precursor is synthesized through multi-step reactions such as amine methylation, nucleophilic substitution and condensation, the ligand precursor is utilized to react with ZnEt2 or Zn [N (SiMe3) 2] 2 to obtain the binuclear metal zinc complex, and the obtained complex has high catalytic activity on lactide ring-opening polymerization, and can be used for preparing the complex for lactide ring-opening polymerization. The ring opening polymerization of the lactide can be catalyzed to generate the polylactide with high molecular weight and narrow molecular weight distribution in the absence of a cocatalyst.

The invention relates to a preparation method of cyclic poly (L-lactide), and belongs to the technical field of polymer preparation. According to the method, the cyclic poly (L-lactide) with high molecular weight is successfully prepared through a solvent-free ring-opening polymerization reaction at the reaction temperature of 110-180 DEG C by taking L-lactide as a polymeric monomer and taking a Sallaen type rare earth metal alkoxy complex as a catalyst. The method disclosed by the invention has the advantages that the catalytic efficiency is relatively high, the molecular weight of the obtained polymer is high, the polymer has a cyclic structure and the like, the method is green and solvent-free, and the product is a polymer only containing a cyclic topological structure.

The invention discloses a dual-response type near-infrared two-region quantum dot nanoprobe as well as preparation and application thereof, and belongs to the technical field of biomedical nanomaterials and molecular imaging. The quantum dot nanoprobe comprises an inner core and a shell, wherein the shell is coated outside the inner core; the inner core comprises a near-infrared emission quantum dot core, and the surface of an NIR-II quantum dot is connected with a response peptide and a quencher; the shell is prepared from a polylactic acid-glycolic acid copolymer, polylactic acid, polycaprolactone, a polylactide-polyethylene glycol copolymer, a polylactide-polycaprolactone copolymer, a polysulfide block copolymer and the like. According to the NIR-II quantum dot nanoprobe disclosed by the invention, a response peptide chain and a fluorescence quencher are introduced through chemical modification, and a signal off-on function is realized, so that an activated fluorescent probe with high specificity and high contrast is constructed; the nano-composite particle with controllable particle size, adjustable fluorescence and stable structure is formed, has targeting property, responsiveness and biocompatibility, and is suitable for accurate real-time imaging in a complex in-vivo environment.

The invention belongs to the technical field of medical treatment, and particularly relates to a preparation method of polylactide caprolactone PLCL used in the medical field, which comprises the following steps: S1, polymerization reaction: taking lactide and caprolactone as raw materials, adding the raw materials into a polymerization kettle, adding a reaction solution into the polymerization kettle, vacuumizing the polymerization kettle, heating and stirring under the heating and stirring action of the polymerization kettle, and reacting for 2-4 hours to obtain a reaction solution; forming a mixed solution; s2, polymer separation: adding a precipitant into the mixed solution to precipitate PLCL, separating PLCL from the reaction solution, and removing the reaction solution on the upper layer to obtain PLCL; s3, polymer drying: heating the PLCL to remove an organic solvent in the PLCL to obtain dried PLCL; and S4, polymer refining: carrying out fine grinding on the dried PLCL by using a grinding machine, screening the ground PLCL by using a fine screen, returning the PLCL which cannot be leaked from meshes of the fine screen to the grinding machine for continuous grinding, and obtaining the PLCL which is high in purity and conforms to the medical implantation level by using the PLCL which is leaked from the meshes of the fine screen.

The polylactide resin composition includes a mixture of 40% to 95% by weight of a crystallizable polylactide resin and 5% to 60% by weight of a certain non-crystallizable polylactide resin. The polylactide resin composition is useful in the manufacture of oriented films, particularly biaxially oriented films. These compositions can be stretched on commercially available biaxial stretching equipment since they can be stretched to a higher stretch ratio than sheets made from crystallizable polylactide resins alone.

This disclosure generally relates to the design of renewably sourced, readily degradable pressure-sensitive adhesives (PSAs) that exhibit tunable adhesion properties is beneficial to address sustainability concerns associated with traditional, fossil fuel-derived counterparts. More generally, aliphatic polyester triblock copolymers of poly(L-lactide)-block-poly(γ-methyl-ε-caprolactone)- blockpoly(L-lactide) (LML) and blends with renewable tackifier in PSA formulations are discussed. More particularly, effects of tackifier, composition, and processing history on microstructural, thermal, mechanical, and adhesive properties of the PSAs are disclosed. Specifically, LML-based PSAs are hydrolytically degradable into water soluble or dispersible compounds at 45°C under basic conditions within 30 days, offering a sustainable end-of-life scenario via its potential in composting makes for an ideal and sustainable alternative for commercial acrylic incumbents.

Non-metallic and compostable twist-tie based on PLA compositions The present invention refers to a non-metallic and compostable twist-tie based on a composition comprising a poly(L-lactide) homopolymer and at least one biodegradable copolymer; and its preparation process.

The invention relates to the field of springs and preparation thereof, in particular to a mattress spring based on finite element optimization and a preparation method thereof, and the mattress spring comprises a comfortable section, a bearing section and a buffer section; the comfortable section is made of a first material, and the first material comprises 33% of flax or jute fiber, 52% of polylactide and polycaprolactone blended resin, 8% of aluminum powder, 2% of a silane coupling agent, 4% of a plasticizer and 1% of an antibacterial agent; the bearing section is made of a second material, and the second material is 60Si2MnA; the buffer section is prepared from a third material, and the third material comprises 20% of flax or jute fiber, 60% of polyurethane prepolymer, 10% of aluminum powder, 8% of chain extender and 2% of functional additive. According to the mattress spring based on finite element optimization and the preparation method of the mattress spring, gradient distribution of mechanical properties in a single spring can be achieved, and the response limitation of a single material is broken through.

The invention relates to the technical field of polymers, and discloses a catalyst composition and application thereof, polylactide and a preparation method thereof. The catalyst composition contains a metal zinc complex with a structure as shown in a formula (I) and a hydroxyl-containing compound, in the formula (I), R1 and R2 are independently selected from hydrogen or C1-C6 alkyl, and R3 is C1-C6 alkyl. When the catalyst composition provided by the invention is used for preparing polylactide through ring-opening polymerization of lactide, the catalytic activity is high, the molecular weight of the obtained polymer is relatively high, the molecular weight is adjustable, and the molecular weight distribution is narrow.

The application belongs to the technical field of biomedical materials, and provides a poly-L-lactide-caprolactone composite material, a preparation method and application thereof, and a vascular stent.The composite material is prepared from poly-L-lactide-caprolactone (PLCL) and metal oxides (one or more of ferroferric oxide, magnesium oxide, zinc oxide and titanium dioxide). Compared with PLLA, the composite material has better strength and toughness; the metal oxides can improve the degradation rate of the polymer PLCL. Therefore, the composite material has excellent toughness, strength and degradation rate. Further, especially when the metal oxide is ferroferric oxide, the elongation at break and tensile strength of the obtained composite material are significantly improved; the in-vitro degradation rate is also significantly improved; and the composite material has excellent biocompatibility.

The polylactide resin composition according to the present invention includes a polylactide oligomer whose end group is a carboxyl group, and thus, has excellent melt strength due to a high branching effect while maintaining the advantages of biodegradation.

The invention relates to the field of medical implant materials, and particularly discloses an absorbable patch for uterine muscular layer repair and a preparation method of the absorbable patch. The invention discloses an absorbable patch for repairing a uterine muscular layer. The absorbable patch is prepared by mixing 2-9.5 parts of poly (L-lactide-caprolactone) and 0.5-8 parts of a biomedical material, the molecular weight of the poly (L-lactide-caprolactone) is 5 to 30 thousand; the preparation method comprises the following steps: mixing a biomedical material stock solution with a poly (L-lactide-caprolactone) stock solution, performing electrostatic spinning, freeze drying or tape casting treatment, and drying to remove an organic solvent, thereby obtaining the absorbable patch for uterine muscular layer repair. The absorbable patch disclosed by the invention not only can be completely degraded in vivo, but also has a similar extracellular matrix structure, can provide muscle cell repair for an injured part of a uterine muscular layer, avoids scar tissues formed by fibrosis, and reduces the risk caused by a secondary operation required by a uterine scar diverticulum.

The present invention relates to a composition comprising polymeso-lactide (PML) and poly-L-lactide (PLA) each with defined properties, and at least one chain extending agent. The invention further relates to substrates coated with a composition of the invention, and to articles comprising or made from such compositions or from such coated substrates. The invention also relates to the use of a composition comprising polymeso-lactide (PML) and poly-L-lactide (PLA) and at least one chain extending agent for various applications, in particular for melt-processing applications such as film production, and extrusion or extrusion coating applications.

The invention belongs to the field of degradable materials, and relates to a biodegradable polyester composition, a non-woven fabric and a preparation method and application of the biodegradable polyester composition and the non-woven fabric. The biodegradable polyester composition comprises a component A, a component B and a component C, wherein the component A is at least one aliphatic-aromatic copolyester which is a copolymer containing repetitive units shown in formulas (I) and (II); a component B: at least one aliphatic polyester which is polylactide; based on the total weight of the biodegradable polyester composition, the content of the component A is 60-95 wt%; the content of the component B is 5-40 wt%; the weight-average molecular weight of the aliphatic-aromatic copolyester ranges from 50000 g / mol to 200000 g / mol; the weight-average molecular weight of the aliphatic polyester ranges from 60000 g / mol to 150000 g / mol. The non-woven fabric prepared from the composition disclosed by the invention has an excellent rigid-tough balance characteristic, and is suitable for agricultural fungus bags, seedling raising bags, disposable hygienic products, sheets, filters, various packaging bags and the like.

The invention belongs to the technical field of thermoplastic elastomers, and particularly relates to polyol with a star-shaped structure and a preparation method and application thereof, and an aliphatic thermoplastic elastomer with a star-shaped structure and a preparation method and application thereof. The polyhydric alcohol with a novel structure is designed and synthesized by taking a multi-arm epoxy compound as a raw material, each molecule of the polyhydric alcohol contains at least one five-membered ring or six-membered ring, and the aliphatic thermoplastic elastomer with a star-shaped structure is further synthesized by taking the polyhydric alcohol as a core, so that collaborative optimization of high tensile strength and high elongation at break is realized; meanwhile, poly (L-lactide) and polycaprolactone are used as chain segments of a block, and the cyclic lactone is derived from biomass, does not depend on petroleum resources, and has the characteristics of reproducibility and degradability.

A long acting injectable formulation based on combination of biodegradable poly(D,L-lactide-co-glycolide) microparticles comprising different PLGA polymers and Tacrolimus. The microparticles may include Tacrolimus, a first polymer and a second polymer, and the first and second polymer may differ from each other. Each of the first and second polymers may be a poly(D,L-lactide-co-glycolide) polymer. Each of the first and second polymers may have an identical lactide to glycolide ratio. Each of the first and second polymers may have a different molecular weight

The application relates to the technical field of polyethylene, and discloses a degradable high-density polyethylene-bio-based polyester blended material for a garbage can and a preparation method thereof; the high-density polyethylene, bio-based polyester, styrene-based citric ester grafted POE, antioxidant and filler are blended, and extruded in a double-screw extruder to obtain the high-density polyethylene-bio-based polyester blended material. The styrene-based citric ester grafted POE improves the compatibility between polyethylene and polylactic acid and the like, and improves the mechanical properties of the blended material. The polylactic acid and polylactide have excellent biodegradability, and the citric ester grafted on the side of the POE also has good biodegradability; when added into the polyethylene material, the biodegradation rate of the blended material can be improved.

A wound dressing including a porous biosynthetic polymer film comprising a poly(lactide-co-caprolactone) (“PLC”) copolymer or other suitable polymer matrix, and a local analgesic loaded therein, to provide pain relief over an extended period of time (e.g., for 5-7 days), e.g., for healing of a partial thickness dermal injury. The PLC copolymer may have a particular lactide / caprolactone molar ratio (e.g., from 2:1 to 9:1) to ensure slow, sustained release of the bupivacaine or other analgesic. The dressing may provide a water vapor transmission rate from 1000 g / m2·day to 3000 g / m2·day to facilitate fast healing and regrowth of new epithelial tissue beneath the dressing. The dressing is configured to remain positioned over the dermal injury, providing wound protection for about 14 days, after which is simply debrides away, falls off, or is easily and painlessly removed, once new epithelial tissue regrows.

The invention relates to a semeglutide sustained-release composition which comprises an active ingredient and a controlled-release material, the active ingredient is semeglutide, and the controlled-release material is polylactide-glycolide; the preparation method comprises the following steps: (1) dissolving the semeglutide in a cosolvent absolute methanol to form a homogeneous solution; (2) mixing and dissolving the solution with a solvent dichloromethane solution in which the PLGA is dissolved; (3) homogenizing and homogenizing; (4) adding a coagulant to form an emulsion; (5) dispersing the emulsion in quenching liquid to solidify the formed microdroplets to form microspheres; (6) cleaning the microspheres; and (7) drying. According to the microsphere preparation capable of continuously and uniformly releasing the large-molecular-weight polypeptide semeglutide and the preparation method of the microsphere preparation, the release speed of a medicine can be adjusted by controlling factors such as the particle size, the form and the pore of the microsphere and interaction between the medicine and a carrier, so that slow release and continuous release of the medicine are realized, and the purpose of long-acting treatment is achieved; and the cost is also reduced.

A biodegradable and biocompatible barrier membrane of piezoelectric nano composites of Metallic Oxide (MO) (e.g., Magnesium oxide, Zinc oxide and iron oxide)-PLLA (Poly-L-lactide), which can be subjected to acoustic pressure from ultrasound, to generate useful electrical charge for enhanced bone regeneration and enhanced antibacterial effects for guided bone regeneration to treat dental diseases, such as periodontitis.

The invention discloses a degradable bio-based material with structural color and a preparation method thereof, and belongs to the technical field of functional materials, the degradable bio-based material comprises the following raw materials by weight: 50-60 parts of polylactide, 30-40 parts of cellulose, 5-7 parts of a flame retardant, 3-5 parts of a plasticizer, and 2-4 parts of an antioxidant. The cellulose is any one of lignin fiber, methyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose and carboxymethyl cellulose. The plasticizer is citric acid ester. The flame retardant is a degradable bio-based flame retardant, and is any one of chitosan, sodium alginate and lignin. The antioxidant comprises a main antioxidant and an auxiliary antioxidant. According to the degradable bio-based material with the structural color and the preparation method of the degradable bio-based material, the performance of the bio-based material can be greatly improved, harmless and degradable materials are adopted, and the use safety is guaranteed.

The embodiment of the utility model belongs to the packaging technology, and provides a pulsator washing machine package and a pulsator washing machine assembly, the pulsator washing machine package comprises a top cover, a safe edge and a bottom cover, the top end of the safe edge is connected with the top cover, and the bottom cover is connected with the bottom end of the safe edge; the bottom cover is a plastic part made of one or more of polypropylene, polyethylene, polyvinyl chloride, polylactide, poly (butylene adipate / terephthalate) and poly (butylene succinate), or the bottom cover body is a composite part formed by a plastic part and a paper part; the bottom cover comprises a bottom cover body and a step structure; the step structure is provided with a containing groove and a limiting protrusion, the containing groove is formed in the top of the step structure, the containing groove is used for containing the support, and the limiting protrusion is arranged in the containing groove and is arranged in the through hole of the support in an inserted mode. Friction and abrasion between the motor shaft and the bearing can be reduced, damage to the motor is reduced, the motor can work normally, and the pulsator washing machine can operate normally.

A method for manufacturing a polylactic acid blown film, the method including preparing a mixture containing polylactide polymer and epoxy-group-containing acrylate terpolymer; subjecting the mixture to reactive extrusion to prepare branched polylactide polymer pellets; and subjecting the pellets to blown extrusion to manufacture a blown film, wherein the epoxy-group-containing acrylate terpolymer includes 30-50 wt % repeat units from first alkyl(meth)acrylate monomers, 30-60 wt % repeat units from glycidyl(meth)acrylate monomers, and 10-20 wt % repeat units from second alkyl(meth)acrylate monomers, and the first alkyl(meth)acrylate monomers and the second alkyl(meth)acrylate monomers are different, and the mixture of step 1 includes the epoxy-group-containing acrylate terpolymer an amount of 0.1 parts by weight or more to less than 1.0 part by weight, based on 100 parts by weight of the polylactide polymer. The polylactic acid blown film has high transparency and excellent surface property and can be provided without an additive such as a plasticizer.