43 results about "Poly dl lactide" patented technology

Disclosed herein is a polysialic acid (PSA)-polymer conjugated compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein P is a poly (lactide-co-glycolide)-poly (ethylene glycol) copolymer (PLGA-PEG) and p is an integer from 4 to 200; nanoparticles comprising the same; and methods of treating ophthalmic diseases using the same. (I)

Symmetric Star Poly(Substituted Glycolide) Homopolymers and Their Surface Properties The invention include the synthesis, thin film formation, surface properties, and comprehensive analysis of star-shaped well-defined symmetric poly(substituted glycolide) (s-PSG) homopolymers, which are alternatives to polylactides and polyglycolides. Four-armed symmetric poly(L-diisopropyl glycolide) (4s-PLDIPG) and poly(L-diisobutyl glycolide) (4s-PLDIBG) prepared by ring opening polymerization (ROP) under melt conditions with tin (II) 2- ethylhexanoate catalyst and pentaerythritol initiator exhibited high conversions (92-98%) and desirable PDI values (1.23-1.49). The NMR data of all s-PSGs showed that the methylene peaks of pentaerythritol were shifted, proving that polymerization took place in all arms. The molecular weights (Mn NMR, Mw GPC, Mn GPC) of s-PSGs determined by NMR and GPC data were consistent with the theoretical values. By increasing the side chain length of s-PSG homopolymers, there was a consistent increase in the water contact angles and surface roughness values of the thin films, whereas the surface free energy diminished.

The application discloses a kind of high uniformity medical grade absorbable polyester, preparation method and production system, production system includes kettle type closed stirrer, auxiliary tank, three-way valve and closed kettle type reactor;Three-way valve is communicated with kettle type closed stirrer by melt metering pump;It is communicated with auxiliary tank by micro-injection pump;It is communicated with closed kettle type reactor by static mixer;The side inside of three-way valve and micro-injection pump communication side is designed funnel shape, including funnel neck and funnel mouth, the side surface and bottom surface of funnel neck are equipped with uniform small hole.The application discloses a kind of system specially used for preparing high uniformity medical grade absorbable polyester and the preparation method matched therewith, by using special production system again cooperation specific process parameter can successfully prepare with medical grade absorbable polyester, especially suitable for the preparation of poly-l-lactide and polyglycolide with higher viscosity, more difficult to produce, the product obtained has high uniformity, high molecular weight and low monomer residue.

The invention provides a binuclear zinc complex based on a bridged bis (beta-diimine) dianion ligand as well as a preparation method and application of the binuclear zinc complex, and belongs to the technical field of preparation and application of metal organic complexes. Starting from p-phenylenediamine, an aryl bridged bis (beta-diimine) ligand precursor is synthesized through multi-step reactions such as amine methylation, nucleophilic substitution and condensation, the ligand precursor is utilized to react with ZnEt2 or Zn [N (SiMe3) 2] 2 to obtain the binuclear metal zinc complex, and the obtained complex has high catalytic activity on lactide ring-opening polymerization, and can be used for preparing the complex for lactide ring-opening polymerization. The ring opening polymerization of the lactide can be catalyzed to generate the polylactide with high molecular weight and narrow molecular weight distribution in the absence of a cocatalyst.

The invention relates to a preparation method of cyclic poly (L-lactide), and belongs to the technical field of polymer preparation. According to the method, the cyclic poly (L-lactide) with high molecular weight is successfully prepared through a solvent-free ring-opening polymerization reaction at the reaction temperature of 110-180 DEG C by taking L-lactide as a polymeric monomer and taking a Sallaen type rare earth metal alkoxy complex as a catalyst. The method disclosed by the invention has the advantages that the catalytic efficiency is relatively high, the molecular weight of the obtained polymer is high, the polymer has a cyclic structure and the like, the method is green and solvent-free, and the product is a polymer only containing a cyclic topological structure.

The invention discloses a dual-response type near-infrared two-region quantum dot nanoprobe as well as preparation and application thereof, and belongs to the technical field of biomedical nanomaterials and molecular imaging. The quantum dot nanoprobe comprises an inner core and a shell, wherein the shell is coated outside the inner core; the inner core comprises a near-infrared emission quantum dot core, and the surface of an NIR-II quantum dot is connected with a response peptide and a quencher; the shell is prepared from a polylactic acid-glycolic acid copolymer, polylactic acid, polycaprolactone, a polylactide-polyethylene glycol copolymer, a polylactide-polycaprolactone copolymer, a polysulfide block copolymer and the like. According to the NIR-II quantum dot nanoprobe disclosed by the invention, a response peptide chain and a fluorescence quencher are introduced through chemical modification, and a signal off-on function is realized, so that an activated fluorescent probe with high specificity and high contrast is constructed; the nano-composite particle with controllable particle size, adjustable fluorescence and stable structure is formed, has targeting property, responsiveness and biocompatibility, and is suitable for accurate real-time imaging in a complex in-vivo environment.

The invention belongs to the technical field of medical treatment, and particularly relates to a preparation method of polylactide caprolactone PLCL used in the medical field, which comprises the following steps: S1, polymerization reaction: taking lactide and caprolactone as raw materials, adding the raw materials into a polymerization kettle, adding a reaction solution into the polymerization kettle, vacuumizing the polymerization kettle, heating and stirring under the heating and stirring action of the polymerization kettle, and reacting for 2-4 hours to obtain a reaction solution; forming a mixed solution; s2, polymer separation: adding a precipitant into the mixed solution to precipitate PLCL, separating PLCL from the reaction solution, and removing the reaction solution on the upper layer to obtain PLCL; s3, polymer drying: heating the PLCL to remove an organic solvent in the PLCL to obtain dried PLCL; and S4, polymer refining: carrying out fine grinding on the dried PLCL by using a grinding machine, screening the ground PLCL by using a fine screen, returning the PLCL which cannot be leaked from meshes of the fine screen to the grinding machine for continuous grinding, and obtaining the PLCL which is high in purity and conforms to the medical implantation level by using the PLCL which is leaked from the meshes of the fine screen.

This disclosure generally relates to the design of renewably sourced, readily degradable pressure-sensitive adhesives (PSAs) that exhibit tunable adhesion properties is beneficial to address sustainability concerns associated with traditional, fossil fuel-derived counterparts. More generally, aliphatic polyester triblock copolymers of poly(L-lactide)-block-poly(γ-methyl-ε-caprolactone)- blockpoly(L-lactide) (LML) and blends with renewable tackifier in PSA formulations are discussed. More particularly, effects of tackifier, composition, and processing history on microstructural, thermal, mechanical, and adhesive properties of the PSAs are disclosed. Specifically, LML-based PSAs are hydrolytically degradable into water soluble or dispersible compounds at 45°C under basic conditions within 30 days, offering a sustainable end-of-life scenario via its potential in composting makes for an ideal and sustainable alternative for commercial acrylic incumbents.

The invention relates to the field of springs and preparation thereof, in particular to a mattress spring based on finite element optimization and a preparation method thereof, and the mattress spring comprises a comfortable section, a bearing section and a buffer section; the comfortable section is made of a first material, and the first material comprises 33% of flax or jute fiber, 52% of polylactide and polycaprolactone blended resin, 8% of aluminum powder, 2% of a silane coupling agent, 4% of a plasticizer and 1% of an antibacterial agent; the bearing section is made of a second material, and the second material is 60Si2MnA; the buffer section is prepared from a third material, and the third material comprises 20% of flax or jute fiber, 60% of polyurethane prepolymer, 10% of aluminum powder, 8% of chain extender and 2% of functional additive. According to the mattress spring based on finite element optimization and the preparation method of the mattress spring, gradient distribution of mechanical properties in a single spring can be achieved, and the response limitation of a single material is broken through.

The polylactide resin composition according to the present invention includes a polylactide oligomer whose end group is a carboxyl group, and thus, has excellent melt strength due to a high branching effect while maintaining the advantages of biodegradation.

The invention relates to the field of medical implant materials, and particularly discloses an absorbable patch for uterine muscular layer repair and a preparation method of the absorbable patch. The invention discloses an absorbable patch for repairing a uterine muscular layer. The absorbable patch is prepared by mixing 2-9.5 parts of poly (L-lactide-caprolactone) and 0.5-8 parts of a biomedical material, the molecular weight of the poly (L-lactide-caprolactone) is 5 to 30 thousand; the preparation method comprises the following steps: mixing a biomedical material stock solution with a poly (L-lactide-caprolactone) stock solution, performing electrostatic spinning, freeze drying or tape casting treatment, and drying to remove an organic solvent, thereby obtaining the absorbable patch for uterine muscular layer repair. The absorbable patch disclosed by the invention not only can be completely degraded in vivo, but also has a similar extracellular matrix structure, can provide muscle cell repair for an injured part of a uterine muscular layer, avoids scar tissues formed by fibrosis, and reduces the risk caused by a secondary operation required by a uterine scar diverticulum.

The present invention relates to a composition comprising polymeso-lactide (PML) and poly-L-lactide (PLA) each with defined properties, and at least one chain extending agent. The invention further relates to substrates coated with a composition of the invention, and to articles comprising or made from such compositions or from such coated substrates. The invention also relates to the use of a composition comprising polymeso-lactide (PML) and poly-L-lactide (PLA) and at least one chain extending agent for various applications, in particular for melt-processing applications such as film production, and extrusion or extrusion coating applications.

The invention belongs to the field of degradable materials, and relates to a biodegradable polyester composition, a non-woven fabric and a preparation method and application of the biodegradable polyester composition and the non-woven fabric. The biodegradable polyester composition comprises a component A, a component B and a component C, wherein the component A is at least one aliphatic-aromatic copolyester which is a copolymer containing repetitive units shown in formulas (I) and (II); a component B: at least one aliphatic polyester which is polylactide; based on the total weight of the biodegradable polyester composition, the content of the component A is 60-95 wt%; the content of the component B is 5-40 wt%; the weight-average molecular weight of the aliphatic-aromatic copolyester ranges from 50000 g / mol to 200000 g / mol; the weight-average molecular weight of the aliphatic polyester ranges from 60000 g / mol to 150000 g / mol. The non-woven fabric prepared from the composition disclosed by the invention has an excellent rigid-tough balance characteristic, and is suitable for agricultural fungus bags, seedling raising bags, disposable hygienic products, sheets, filters, various packaging bags and the like.

The invention belongs to the technical field of thermoplastic elastomers, and particularly relates to polyol with a star-shaped structure and a preparation method and application thereof, and an aliphatic thermoplastic elastomer with a star-shaped structure and a preparation method and application thereof. The polyhydric alcohol with a novel structure is designed and synthesized by taking a multi-arm epoxy compound as a raw material, each molecule of the polyhydric alcohol contains at least one five-membered ring or six-membered ring, and the aliphatic thermoplastic elastomer with a star-shaped structure is further synthesized by taking the polyhydric alcohol as a core, so that collaborative optimization of high tensile strength and high elongation at break is realized; meanwhile, poly (L-lactide) and polycaprolactone are used as chain segments of a block, and the cyclic lactone is derived from biomass, does not depend on petroleum resources, and has the characteristics of reproducibility and degradability.

The application relates to the technical field of polyethylene, and discloses a degradable high-density polyethylene-bio-based polyester blended material for a garbage can and a preparation method thereof; the high-density polyethylene, bio-based polyester, styrene-based citric ester grafted POE, antioxidant and filler are blended, and extruded in a double-screw extruder to obtain the high-density polyethylene-bio-based polyester blended material. The styrene-based citric ester grafted POE improves the compatibility between polyethylene and polylactic acid and the like, and improves the mechanical properties of the blended material. The polylactic acid and polylactide have excellent biodegradability, and the citric ester grafted on the side of the POE also has good biodegradability; when added into the polyethylene material, the biodegradation rate of the blended material can be improved.

A wound dressing including a porous biosynthetic polymer film comprising a poly(lactide-co-caprolactone) (“PLC”) copolymer or other suitable polymer matrix, and a local analgesic loaded therein, to provide pain relief over an extended period of time (e.g., for 5-7 days), e.g., for healing of a partial thickness dermal injury. The PLC copolymer may have a particular lactide / caprolactone molar ratio (e.g., from 2:1 to 9:1) to ensure slow, sustained release of the bupivacaine or other analgesic. The dressing may provide a water vapor transmission rate from 1000 g / m2·day to 3000 g / m2·day to facilitate fast healing and regrowth of new epithelial tissue beneath the dressing. The dressing is configured to remain positioned over the dermal injury, providing wound protection for about 14 days, after which is simply debrides away, falls off, or is easily and painlessly removed, once new epithelial tissue regrows.

The embodiment of the utility model belongs to the packaging technology, and provides a pulsator washing machine package and a pulsator washing machine assembly, the pulsator washing machine package comprises a top cover, a safe edge and a bottom cover, the top end of the safe edge is connected with the top cover, and the bottom cover is connected with the bottom end of the safe edge; the bottom cover is a plastic part made of one or more of polypropylene, polyethylene, polyvinyl chloride, polylactide, poly (butylene adipate / terephthalate) and poly (butylene succinate), or the bottom cover body is a composite part formed by a plastic part and a paper part; the bottom cover comprises a bottom cover body and a step structure; the step structure is provided with a containing groove and a limiting protrusion, the containing groove is formed in the top of the step structure, the containing groove is used for containing the support, and the limiting protrusion is arranged in the containing groove and is arranged in the through hole of the support in an inserted mode. Friction and abrasion between the motor shaft and the bearing can be reduced, damage to the motor is reduced, the motor can work normally, and the pulsator washing machine can operate normally.

A method for manufacturing a polylactic acid blown film, the method including preparing a mixture containing polylactide polymer and epoxy-group-containing acrylate terpolymer; subjecting the mixture to reactive extrusion to prepare branched polylactide polymer pellets; and subjecting the pellets to blown extrusion to manufacture a blown film, wherein the epoxy-group-containing acrylate terpolymer includes 30-50 wt % repeat units from first alkyl(meth)acrylate monomers, 30-60 wt % repeat units from glycidyl(meth)acrylate monomers, and 10-20 wt % repeat units from second alkyl(meth)acrylate monomers, and the first alkyl(meth)acrylate monomers and the second alkyl(meth)acrylate monomers are different, and the mixture of step 1 includes the epoxy-group-containing acrylate terpolymer an amount of 0.1 parts by weight or more to less than 1.0 part by weight, based on 100 parts by weight of the polylactide polymer. The polylactic acid blown film has high transparency and excellent surface property and can be provided without an additive such as a plasticizer.

The application provides a zinc biguanide complex and a preparation method thereof and a preparation method of polylactide. The chemical structural formula of the zinc biguanide complex is shown in the following formula: The application further provides a preparation method of polylactide, which comprises the following steps: uniformly mixing lactide monomers with the zinc biguanide complex, and heating to make the lactide monomers perform a polymerization reaction to obtain polylactide. The application uses a low-toxicity organic metal catalyst to replace a toxic stannous octoate catalyst, efficiently catalyzes the ring-opening of lactone, and is used for realizing a green and environment-friendly process to produce aliphatic polyester.

The present invention relates to an electrospun multilayer tube or wrap for the protection or bridging of damaged nerves, comprising an electrospun isolating outer layer and at least one electrospun inner layer, the electrospun isolating outer layer comprising at least one polymer selected from the group consisting of polycaprolactone, polylactide, polyglycolide, polytrimethylene carbonate, polydioxanone, polyethylene glycol, polyurethane, copolymers thereof or mixtures thereof, the at least one electrospun inner layer comprising an agent capable of forming a covalent bond with proteins and peptides, the agent comprising at least one group selected from the group consisting of N-hydroxysuccinimide, maleimide, thio-NHS, biotin-NHS, carboxylic acid or aldehyde. Furthermore, the present invention relates to a method of manufacturing such a tube or wrap and to their use for the protection or bridging of nerves or for stimulating nerve growth and cell proliferation.

The embodiment of the utility model belongs to the packaging technology, and provides a pulsator washing machine package and a pulsator washing machine assembly, and the pulsator washing machine package comprises a top cover, angle beads and a bottom cover; the top ends of the corner protectors are connected with the top cover; the bottom cover is connected with the bottom end of the angle bead, and the bottom cover is a plastic part made of one or more of polypropylene, polyethylene, polyvinyl chloride, polylactide, poly (butylene adipate / terephthalate) and poly (butylene succinate); or the bottom cover body is a composite piece formed by a plastic piece and a paper piece; the bottom cover comprises a bottom cover body and a step structure; the step structure comprises a first inserting part and a second inserting part, the first inserting part is connected with the bottom cover body in an inserting manner, and the second inserting part is connected with the first inserting part in an inserting manner; the limiting piece penetrates through the step body and is inserted into the bottom cover body. The environment-friendly performance of the bottom cover can be improved, and harm to the environment can be reduced.

This invention belongs to the field of metal complex preparation and application, and discloses a tetranuclear cuboane-configured zinc complex, its preparation method, and its application. The tetranuclear cuboane-configured zinc complex is used to catalyze the ring-opening polymerization of lactide. Using the tetranuclear cuboane-configured zinc complex as a catalyst and racemic lactide as a raw material, under anhydrous, oxygen-free, and inert gas protection conditions, in bulk conditions, the ring-opening polymerization of lactide can be catalyzed to prepare polylactide without the participation of a co-catalyst. The catalyst preparation method is simple, the catalyst is non-toxic, has a novel structure, high catalytic activity, and requires a low catalyst dosage during the catalytic process.

The invention discloses an SIS-loaded polymer tubular structure artificial blood vessel, and relates to the technical field of biomedical treatment, and the SIS-loaded polymer tubular structure artificial blood vessel comprises a polymer tubular structure which is prepared from a high polymer material through an electrostatic spinning or 3D printing process, the high polymer material is selected from at least one of polycaprolactone, polylactic acid, polyurethane, a polylactic acid-glycolic acid copolymer, poly (L-lactide-caprolactone) or poly (p-dioxanone); and the SIS layer is prepared by dissolving SIS powder in 0.1-1M acetic acid solution to prepare a 1%-10% solution. The invention relates to a preparation method of an SIS-loaded polymer tubular structure artificial blood vessel. The preparation method comprises the following steps: preparing SIS: cleaning and segmenting fresh small intestine and jejunum, and scraping an outer membrane, a muscular layer and an inner mucosa; according to the invention, a physical perfusion-freeze drying method is innovatively adopted to realize efficient loading of SIS; and more than 95% of active factors in the SIS are reserved through a gradient decellularization process.

This invention provides an artificial dura mater material, its preparation method, and its applications, belonging to the field of biomedical technology. Addressing the shortcomings of traditional synthetic dura mater, this invention utilizes poly(L-lactide-caprolactone) (PLCL) with a specific concentration of RAPA, processed using electrospinning. It exhibits low porosity and a dense texture, inducing rapid endothelialization of the dura mater in the early stages of traumatic brain injury. Subsequently, with the release of RAPA, the material's porosity increases, facilitating the proliferation and growth of newly formed dura mater cells. Simultaneously, RAPA can prevent excessive proliferation of new endothelial cells and scar hyperplasia. It can selectively inhibit pathological proliferation without impairing necessary lymphatic drainage; while maintaining the physical structural integrity of the dura mater, it can promote neurological function repair.

The invention discloses a preparation method of an absorbable antibacterial coating material capable of slowly releasing antibiotics. The preparation method comprises the following steps: step 1, blending antibiotics, an absorbable polymer and a mixed solvent to obtain a coating solution; the antibiotics are selected from rifampicin and minocycline hydrochloride; the absorbable polymer is selected from one or more of polyglycolide, polylactide, polyglycolide-co-lactide, polyglycolide-co-caprolactone and tyrosine polyarylester; the absorbable polymer is selected from one or more of polyglycolide, polylactide, polyglycolide-co-lactide, polyglycolide-co-caprolactone and tyrosine polyarylester; the mixed solvent is selected from hexafluoroisopropanol and acetonitrile, and the volume ratio of the hexafluoroisopropanol in the mixed solvent is not less than 25%; and 2, uniformly spraying the coating solution on the surface of the degradable base material through ultrasonic spraying, and then carrying out drying treatment. According to the preparation method disclosed by the invention, the antibiotic, the absorbable polymer and the organic solvent are blended and dissolved and then are attached to the surface of the absorbable material through ultrasonic spraying, and the release of the antibiotic is regulated and controlled while the stability of the coating is ensured by regulating and controlling the ratio of the antibiotic to the polymer and the swelling characteristic of the solvent to the base material.

The invention discloses a poly (p-dioxanone) drug-loaded microsphere, which comprises a microsphere main material, a bioactive substance and a drug, the microsphere main material is prepared by using a poly (p-dioxanone) monomer as a raw material through an emulsion polymerization method, and the bioactive substance is a synthetic degradable high polymer material and a natural biodegradable high polymer material. Comprising but not limited to polylactide and polyglycolide. According to the poly (p-dioxanone) drug-loaded microsphere as well as the preparation method and the application thereof, the monomer (p-dioxanone) and the required drug are taken as raw materials, the raw materials are continuously polymerized and wrap the drug in the emulsification process to form poly (p-dioxanone) with a certain molecular weight, and a certain bioactive substance can be added, so that the poly (p-dioxanone) drug-loaded microsphere is relatively wide in application range and relatively low in cost. According to the microsphere stability and biocompatibility, the degradation time can be controlled by controlling the catalyst and the polymerization time, a certain slow release property is achieved, the toxic and side effects are reduced, the preparation method is simple, and industrial production is facilitated.

The present invention provides a method for predicting or evaluating the necking performance of a film made of a polylactide resin, which is simple and has high prediction accuracy, and thus can replace an actual measurement method, thereby predetermining the film performance of a new structure.

The invention relates to an electrospun hybrid scaffold for medical applications comprising at least one synthetic polymer selected from poly(caprolactone), polylactide, poly(trimethylene carbonate), poly(lactide-co-caprolactone), poly(lactide-co-trimethylene carbonate), polylactide-b-polyethylene glycol, their copolymers or mixtures thereof and collagen-like protein. The invention also relates to methods of dispersing collagen-like protein into synthetic resorbable polymers and forming compositions suitable for electrospinning.

The invention discloses a method for improving the stability of a urease inhibitor, and belongs to the technical field of urease inhibitors. The preparation method of the microcapsule type urease inhibitor comprises the following steps: adding an organic solvent into a capsule wall material, heating, adding a dispersing agent and a urease inhibitor, and cooling to obtain the microcapsule type urease inhibitor, wherein the capsule wall material comprises one or more of polyvinyl acetate, polycaprolactone, polylactide, ethyl cellulose, poly (butylene succinate), polyethylene glycol, beeswax, solid paraffin, polyethylene, polypropylene and polystyrene. The microcapsule type urease inhibitor prepared by the invention can improve the adding stability of the urease inhibitor in a fertilizer, and solves the problem of poor adding stability of the urease inhibitor in the fertilizer to a certain extent.