99 results about "Poly dl lactide" patented technology

A collagen membrane with an effect of inducing ordered remodeling of tissues, a preparation method therefor, and use thereof, relating to the technical field of surgical supply materials. The preparation method for the collagen membrane comprises the following steps: subjecting a fiber membrane to a heat pressing treatment to obtain the collagen membrane with the effect of inducing ordered remodeling of tissues. The fiber membrane is formed by cross-stacked fibers with a diameter of 0.5-15 μm. The fibers comprise collagen and poly(L-lactide-co-caprolactone). The mass ratio of the collagen to the poly(L-lactide-co-caprolactone) is 1:(1.5-2.5). By combining the collagen, which has good biocompatibility and an effect of promoting tissue repair, with PLCL, which is biodegradable and features excellent mechanical properties and good cell adhesion, the collagen membrane not only has an extracellular matrix-like structure, but also exhibits good structural stability, facilitating the regulation of cell behaviors and tissue regeneration, and effectively promoting the growth, adhesion, and proliferation of host cells, thereby inducing ordered remodeling of tissues.

The invention belongs to the technical field of pressure-sensitive adhesives, and provides a biodegradable pressure-sensitive adhesive and a preparation method thereof. The biodegradable pressure-sensitive adhesive is prepared from the following raw materials in parts by weight: 50 to 60 parts of polybutylene succinate, 20 to 30 parts of degradable thermoplastic elastomer, 20 to 30 parts of tackifying resin, 6 to 12 parts of plasticizer, 0.5 to 1.5 parts of mildew preventive, 0.5 to 2 parts of antioxidant and 0.3 to 1 part of anti-aging agent, wherein the degradable thermoplastic elastomer is a polycaprolactone-polylactide segmented copolymer, the weight-average relative molecular mass of the degradable thermoplastic elastomer is 50000 to 70000, and the content of a polycaprolactone phase in the polycaprolactone-polylactide segmented copolymer is 65 to 80 percent. The biodegradable pressure-sensitive adhesive not only has excellent adhesive property, but also has excellent biodegradability, and can effectively overcome the defects of weak cohesion, poor adhesive property and poor degradability of the existing hot-melt pressure-sensitive adhesive containing the thermoplastic elastomer.

A stable sustained release injectable formulation based on poly(D,L-lactide-co-glycolide) microparticles comprising levothyroxine is described. The formulation has a theoretical levothyroxine loading of at least 1.5% w / w. A process for preparing the microparticles is also described. The formulation may be used to control hypothyroidism in adults, congenital hypothyroidism in infants, and acquired hypothyroidism in children.

The invention belongs to the technical field of surgical article materials, and particularly relates to a collagen membrane with an effect of inducing ordered remodeling of tissues as well as a preparation method and application of the collagen membrane. The collagen membrane is obtained by performing hot pressing treatment on a fiber membrane; the fiber membrane is formed by crossing and laminating fibers with the diameter of 0.5-15 microns; the fiber comprises collagen and poly (L-lactide-caprolactone), and the mass ratio of the collagen to the poly (L-lactide-caprolactone) is 1: (1.5-2.5). The collagen membrane provided by the invention combines collagen with good biocompatibility and a tissue repair promoting effect with biodegradable PLCL with excellent mechanical properties and good cell adhesion, not only has an extracellular matrix-like structure, but also has good structural stability, is beneficial to regulation of cell behaviors and tissue regeneration, and can be used for preparing the collagen membrane. The growth, adhesion and proliferation of host cells can be effectively promoted, so that ordered remodeling of tissues is induced.

Provided are compositions that include a histone deacetylase inhibitor (HDACi) encapsulated in and / or otherwise associated with a nanoparticle. In some embodiments, the HDACi is romidepsin, vorinostat, belinostat, panobinostat, and / or chidamide. In some embodiments, the nanoparticle is a poly(D,L-lactide)-PEG-methyl ether (mPEG-PDLLA) nanopolymer. Also provided are methods for treating diseases, disorders, and / or conditions associated with sensitivity to histone deacetylase inhibitors, such as but not limited to tumors and / or cancers; and methods for inhibiting the growth, proliferation, and / or metastasis of a tumor and / or a cancer associated with sensitivity to histone deacetylase inhibitors by administering an effective amount of a composition as disclosed herein, which methods can optionally include administering at least one additional therapeutically active agent, such as but not limited to a chemotherapeutic agent.

The utility model relates to the technical field of packaging, and provides a package of a clothes processing device and a clothes processing device assembly. The supporting assembly of the package of the clothes treating device is installed on the bottom lining and is a plastic part made of one or more of polypropylene, polyethylene, polyvinyl chloride and polylactide. The supporting assembly comprises a first supporting body, a second supporting body and a barrel supporting body for supporting the outer barrel. The first supporting body is located on the rear side, close to the shell, of the bottom lining to support the bottom of the motor. The first reference surface divides the bottom lining into a first bottom lining part and a second bottom lining part, and at least part of the cylinder supporting body is located on the first bottom lining part and at least part of the cylinder supporting body is located on the second bottom lining part. The second supporting body is located on the bottom lining close to the door body so as to support the balancing weight. According to the package of the clothes processing device, the supporting performance of the supporting assembly on all parts in the clothes processing device can be effectively improved, and the protection effect on the clothes processing device is improved.

The invention relates to a process for recycling polylactic acid (PLA) into lactic acid, comprising the steps of: a) hydrolysing a PLA waste thereby obtaining a crude lactic acid composition; b) diluting the crude lactic acid composition in water, thereby producing a diluted crude lactic acid composition; c) equilibrating the diluted crude lactic acid composition for a equilibration period te at a equilibration temperature of at least Te, thereby producing an equilibrated crude lactic acid composition; d) concentrating the equilibrated crude lactic acid composition, thereby producing a concentrated crude lactic acid composition; e) optionally, distilling the concentrated crude lactic acid composition thereby producing a distilled lactic acid composition; and f) crystallizing the concentrated crude lactic acid composition obtained in step d), or the distilled lactic acid composition obtained in step e), thereby recovering lactic acid. The invention also relates to lactic acid obtained when carrying out the process of the invention and their use in the preparation of lactide and / or polylactide.

The present invention belongs to the technical field of patch materials and relates to a double-layer composite patch with a healing and repairing function and a preparation method thereof. The double-layer composite patch is composed of an oriented fiber layer and a random dense layer composited up and down; the components of the oriented fiber layer are synthetic polymers and natural polymers, the synthetic polymer is polylactic acid, poly (L-lactide-caprolactone) or poly (lactic acid-glycolic acid copolymer), and the natural polymer is insoluble type I collagen; during preparation, the oriented fiber membrane obtained by electrospinning is first cut and pre-tensioned and placed in a bidirectional clamping device, and then the bidirectional clamping device is placed in a vacuum oven for annealing treatment, and finally the random dense membrane obtained by electrospinning and the oriented fiber membrane after annealing treatment are composited by ultrasonic welding to obtain the double-layer composite patch. The double-layer composite patch of the present invention has both anti-inflammatory and repair functions while achieving the synergy of "exogenous efficient barrier" and "endogenous precise guidance" functions; the preparation method is simple.

Disclosed herein is a polysialic acid (PSA)-polymer conjugated compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein P is a poly (lactide-co-glycolide)-poly (ethylene glycol) copolymer (PLGA-PEG) and p is an integer from 4 to 200; nanoparticles comprising the same; and methods of treating ophthalmic diseases using the same. (I)

Symmetric Star Poly(Substituted Glycolide) Homopolymers and Their Surface Properties The invention include the synthesis, thin film formation, surface properties, and comprehensive analysis of star-shaped well-defined symmetric poly(substituted glycolide) (s-PSG) homopolymers, which are alternatives to polylactides and polyglycolides. Four-armed symmetric poly(L-diisopropyl glycolide) (4s-PLDIPG) and poly(L-diisobutyl glycolide) (4s-PLDIBG) prepared by ring opening polymerization (ROP) under melt conditions with tin (II) 2- ethylhexanoate catalyst and pentaerythritol initiator exhibited high conversions (92-98%) and desirable PDI values (1.23-1.49). The NMR data of all s-PSGs showed that the methylene peaks of pentaerythritol were shifted, proving that polymerization took place in all arms. The molecular weights (Mn NMR, Mw GPC, Mn GPC) of s-PSGs determined by NMR and GPC data were consistent with the theoretical values. By increasing the side chain length of s-PSG homopolymers, there was a consistent increase in the water contact angles and surface roughness values of the thin films, whereas the surface free energy diminished.

To provide a pharmaceutical composition for cancer treatment which shows a synergistic cancer therapeutic effect when used in combination with an anti-tumor agent, and can be easily used as a cancer therapeutic agent and a combination therapeutic pharmaceutical.SOLUTION: Provided is a cancer treatment application of nanoparticles containing a slightly soluble camptothecin-based compound and a combined administration therapy with an anti-tumor agent using the application. In one embodiment, a combination pharmaceutical preparation for pancreatic cancer treatment contains: particles including SN-38(7-ethyl-10-hydroxycamptothecin), irinotecan, and an amphiphilic block copolymer made of a hydrophobic block and a hydrophilic block; and one or more kinds of anti-tumor agents selected from the group consisting of nab-paclitaxel as an active ingredient, the amphiphilic block copolymer being constituted of A-B or A-B-A block, (a) A is a hydrophilic polymer and is monomethoxypolyethylene, and (b) B is a hydrophobic polymer and is poly-D,L-lactide or a derivative thereof.SELECTED DRAWING: Figure 2

The present invention relates to the field of polymerizing lactic acid to form polylactic acid (PLA). In particular, the present invention relates to a process for bulk polymerization during the production of PLA. The invention also relates to a device for carrying out the process according to the invention and to the use of the process or device according to the invention in the production of polylactide polymers.

The application discloses a kind of high uniformity medical grade absorbable polyester, preparation method and production system, production system includes kettle type closed stirrer, auxiliary tank, three-way valve and closed kettle type reactor;Three-way valve is communicated with kettle type closed stirrer by melt metering pump;It is communicated with auxiliary tank by micro-injection pump;It is communicated with closed kettle type reactor by static mixer;The side inside of three-way valve and micro-injection pump communication side is designed funnel shape, including funnel neck and funnel mouth, the side surface and bottom surface of funnel neck are equipped with uniform small hole.The application discloses a kind of system specially used for preparing high uniformity medical grade absorbable polyester and the preparation method matched therewith, by using special production system again cooperation specific process parameter can successfully prepare with medical grade absorbable polyester, especially suitable for the preparation of poly-l-lactide and polyglycolide with higher viscosity, more difficult to produce, the product obtained has high uniformity, high molecular weight and low monomer residue.

Provided are an absorbable biomedical polymer material, a ligation clip, and a method for preparing same. The ingredients selected for the absorbable biomedical polymer material consist of a first polymer and a second polymer. The first polymer consists of 50 wt%-100 wt% of poly(L-lactide) and 0 wt%-50 wt% of polyglycolide, and the second polymer is poly(p-dioxanone). The absorbable biomedical polymer material has suitable rigidity and flexibility, and can be used in preparing a medical device, such as a ligation clip. In particular, when containing 2.5 wt%-40 wt% of the first polymer, the ligation clip can readily pierce the fascia, and is less likely to undergo plastic deformation at a bend. Also disclosed are some structural forms of ligation clips and a method for preparing same.

The invention provides a binuclear zinc complex based on a bridged bis (beta-diimine) dianion ligand as well as a preparation method and application of the binuclear zinc complex, and belongs to the technical field of preparation and application of metal organic complexes. Starting from p-phenylenediamine, an aryl bridged bis (beta-diimine) ligand precursor is synthesized through multi-step reactions such as amine methylation, nucleophilic substitution and condensation, the ligand precursor is utilized to react with ZnEt2 or Zn [N (SiMe3) 2] 2 to obtain the binuclear metal zinc complex, and the obtained complex has high catalytic activity on lactide ring-opening polymerization, and can be used for preparing the complex for lactide ring-opening polymerization. The ring opening polymerization of the lactide can be catalyzed to generate the polylactide with high molecular weight and narrow molecular weight distribution in the absence of a cocatalyst.

The invention relates to a preparation method of cyclic poly (L-lactide), and belongs to the technical field of polymer preparation. According to the method, the cyclic poly (L-lactide) with high molecular weight is successfully prepared through a solvent-free ring-opening polymerization reaction at the reaction temperature of 110-180 DEG C by taking L-lactide as a polymeric monomer and taking a Sallaen type rare earth metal alkoxy complex as a catalyst. The method disclosed by the invention has the advantages that the catalytic efficiency is relatively high, the molecular weight of the obtained polymer is high, the polymer has a cyclic structure and the like, the method is green and solvent-free, and the product is a polymer only containing a cyclic topological structure.

The invention discloses a dual-response type near-infrared two-region quantum dot nanoprobe as well as preparation and application thereof, and belongs to the technical field of biomedical nanomaterials and molecular imaging. The quantum dot nanoprobe comprises an inner core and a shell, wherein the shell is coated outside the inner core; the inner core comprises a near-infrared emission quantum dot core, and the surface of an NIR-II quantum dot is connected with a response peptide and a quencher; the shell is prepared from a polylactic acid-glycolic acid copolymer, polylactic acid, polycaprolactone, a polylactide-polyethylene glycol copolymer, a polylactide-polycaprolactone copolymer, a polysulfide block copolymer and the like. According to the NIR-II quantum dot nanoprobe disclosed by the invention, a response peptide chain and a fluorescence quencher are introduced through chemical modification, and a signal off-on function is realized, so that an activated fluorescent probe with high specificity and high contrast is constructed; the nano-composite particle with controllable particle size, adjustable fluorescence and stable structure is formed, has targeting property, responsiveness and biocompatibility, and is suitable for accurate real-time imaging in a complex in-vivo environment.

The invention belongs to the technical field of medical treatment, and particularly relates to a preparation method of polylactide caprolactone PLCL used in the medical field, which comprises the following steps: S1, polymerization reaction: taking lactide and caprolactone as raw materials, adding the raw materials into a polymerization kettle, adding a reaction solution into the polymerization kettle, vacuumizing the polymerization kettle, heating and stirring under the heating and stirring action of the polymerization kettle, and reacting for 2-4 hours to obtain a reaction solution; forming a mixed solution; s2, polymer separation: adding a precipitant into the mixed solution to precipitate PLCL, separating PLCL from the reaction solution, and removing the reaction solution on the upper layer to obtain PLCL; s3, polymer drying: heating the PLCL to remove an organic solvent in the PLCL to obtain dried PLCL; and S4, polymer refining: carrying out fine grinding on the dried PLCL by using a grinding machine, screening the ground PLCL by using a fine screen, returning the PLCL which cannot be leaked from meshes of the fine screen to the grinding machine for continuous grinding, and obtaining the PLCL which is high in purity and conforms to the medical implantation level by using the PLCL which is leaked from the meshes of the fine screen.

The polylactide resin composition includes a mixture of 40% to 95% by weight of a crystallizable polylactide resin and 5% to 60% by weight of a certain non-crystallizable polylactide resin. The polylactide resin composition is useful in the manufacture of oriented films, particularly biaxially oriented films. These compositions can be stretched on commercially available biaxial stretching equipment since they can be stretched to a higher stretch ratio than sheets made from crystallizable polylactide resins alone.

This disclosure generally relates to the design of renewably sourced, readily degradable pressure-sensitive adhesives (PSAs) that exhibit tunable adhesion properties is beneficial to address sustainability concerns associated with traditional, fossil fuel-derived counterparts. More generally, aliphatic polyester triblock copolymers of poly(L-lactide)-block-poly(γ-methyl-ε-caprolactone)- blockpoly(L-lactide) (LML) and blends with renewable tackifier in PSA formulations are discussed. More particularly, effects of tackifier, composition, and processing history on microstructural, thermal, mechanical, and adhesive properties of the PSAs are disclosed. Specifically, LML-based PSAs are hydrolytically degradable into water soluble or dispersible compounds at 45°C under basic conditions within 30 days, offering a sustainable end-of-life scenario via its potential in composting makes for an ideal and sustainable alternative for commercial acrylic incumbents.

Non-metallic and compostable twist-tie based on PLA compositions The present invention refers to a non-metallic and compostable twist-tie based on a composition comprising a poly(L-lactide) homopolymer and at least one biodegradable copolymer; and its preparation process.

The invention relates to the field of springs and preparation thereof, in particular to a mattress spring based on finite element optimization and a preparation method thereof, and the mattress spring comprises a comfortable section, a bearing section and a buffer section; the comfortable section is made of a first material, and the first material comprises 33% of flax or jute fiber, 52% of polylactide and polycaprolactone blended resin, 8% of aluminum powder, 2% of a silane coupling agent, 4% of a plasticizer and 1% of an antibacterial agent; the bearing section is made of a second material, and the second material is 60Si2MnA; the buffer section is prepared from a third material, and the third material comprises 20% of flax or jute fiber, 60% of polyurethane prepolymer, 10% of aluminum powder, 8% of chain extender and 2% of functional additive. According to the mattress spring based on finite element optimization and the preparation method of the mattress spring, gradient distribution of mechanical properties in a single spring can be achieved, and the response limitation of a single material is broken through.

The invention belongs to the technical field of biomedical materials, and provides a poly L-lactide-caprolactone composite material, a preparation method and application thereof, and an intravascular stent. The composite material is prepared from poly L-lactide-caprolactone (PLCL) and a metal oxide (one or more of ferric oxide, magnesium oxide, zinc oxide and titanium dioxide) as preparation raw materials. Compared with PLLA, the composite material provided by the invention has better strength and toughness; the metal oxide can improve the degradation speed of the polymer PLCL. Therefore, the composite material disclosed by the invention has excellent toughness, strength and degradation speed. Furthermore, particularly when the metal oxide is ferric oxide, the elongation at break and the tensile strength of the obtained composite material are remarkably improved; in addition, the in-vitro degradation rate is also obviously improved; meanwhile, the biocompatibility is excellent.

The invention relates to the technical field of polymers, and discloses a catalyst composition and application thereof, polylactide and a preparation method thereof. The catalyst composition contains a metal zinc complex with a structure as shown in a formula (I) and a hydroxyl-containing compound, in the formula (I), R1 and R2 are independently selected from hydrogen or C1-C6 alkyl, and R3 is C1-C6 alkyl. When the catalyst composition provided by the invention is used for preparing polylactide through ring-opening polymerization of lactide, the catalytic activity is high, the molecular weight of the obtained polymer is relatively high, the molecular weight is adjustable, and the molecular weight distribution is narrow.

The application belongs to the technical field of biomedical materials, and provides a poly-L-lactide-caprolactone composite material, a preparation method and application thereof, and a vascular stent.The composite material is prepared from poly-L-lactide-caprolactone (PLCL) and metal oxides (one or more of ferroferric oxide, magnesium oxide, zinc oxide and titanium dioxide). Compared with PLLA, the composite material has better strength and toughness; the metal oxides can improve the degradation rate of the polymer PLCL. Therefore, the composite material has excellent toughness, strength and degradation rate. Further, especially when the metal oxide is ferroferric oxide, the elongation at break and tensile strength of the obtained composite material are significantly improved; the in-vitro degradation rate is also significantly improved; and the composite material has excellent biocompatibility.

The polylactide resin composition according to the present invention includes a polylactide oligomer whose end group is a carboxyl group, and thus, has excellent melt strength due to a high branching effect while maintaining the advantages of biodegradation.

The invention relates to the field of medical implant materials, and particularly discloses an absorbable patch for uterine muscular layer repair and a preparation method of the absorbable patch. The invention discloses an absorbable patch for repairing a uterine muscular layer. The absorbable patch is prepared by mixing 2-9.5 parts of poly (L-lactide-caprolactone) and 0.5-8 parts of a biomedical material, the molecular weight of the poly (L-lactide-caprolactone) is 5 to 30 thousand; the preparation method comprises the following steps: mixing a biomedical material stock solution with a poly (L-lactide-caprolactone) stock solution, performing electrostatic spinning, freeze drying or tape casting treatment, and drying to remove an organic solvent, thereby obtaining the absorbable patch for uterine muscular layer repair. The absorbable patch disclosed by the invention not only can be completely degraded in vivo, but also has a similar extracellular matrix structure, can provide muscle cell repair for an injured part of a uterine muscular layer, avoids scar tissues formed by fibrosis, and reduces the risk caused by a secondary operation required by a uterine scar diverticulum.

The invention discloses a lumepirone long-acting sustained-release preparation composition, which comprises lumepirone or a salt thereof and a high polymer material, the mass ratio of lumepirone to the high polymer material is 0.5: 9.5-5: 5, the high polymer material comprises a main material polylactide and an optional release regulator, the mass of the release regulator is 0-95% of that of the main material polylactide, and the mass of the release regulator is 0-95% of that of the main material polylactide. And the release regulator is selected from one or a mixture of more of polylactide or polylactide-glycolide. The long-acting sustained-release preparation disclosed by the invention can realize unequal sustained-release effects of 1 week to 3 months, can improve the compliance of a patient, has no obvious burst release and no release retardation period in the early stage, is stable in release, and ensures the safety and effectiveness of drug release.

The present invention relates to the field of polymerizing lactic acid to form polylactic acid (PLA). In particular, the present invention relates to a process for bulk polymerization during the production of PLA. The invention also relates to a device for carrying out the process according to the invention and to the use of the process or device according to the invention in the production of polylactide polymers.