4892 results about "Compatibilization" patented technology

The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.

Disclosed herein are polymer blends comprising at least one ethylene/α-olefin interpolymer and two different polyolefins which can be homopolymers. The ethylene/α-olefin interpolymers are block copolymers comprising at least a hard block and at least a soft block. In some embodiments, the ethylene/α-olefin interpolymer can function as a compatibilizer between the two polyolefins which may not be otherwise compatible. Methods of making the polymer blends and molded articles made from the polymer blends are also described.

A composition comprising in admixture with a polymer, preferably a polyurethane, and a compatible surface-modifying macromolecule having (i) a central portion of a segmented block oligomeric copolymer comprising at least one polar hard segment, and (ii) PROPORTIONAL - omega terminal polyfluoro oligomeric groups, in a surface modifying enhancing amount. The composition is of use in providing articles having improved surface properties, particularly, medical devices having improved resistance to enzyme degradation with acceptable blood compatibility.

The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymer compositions comprise polymerized silicon-containing monomers end-capped with polymerizable cationic hydrophilic groups.

The present invention is directed to polymeric materials made of biodegradable, bioabsorbable triblock copolymers and implantable devices (e.g., drug-delivery stents) containing such polymeric materials. The polymeric materials may also contain at least one therapeutic substance. The polymeric materials are formulated so as to improve the mechanical and adhesion properties, degradation, biocompatibility and drug permeability of such materials and, thus, implantable devices formed of such materials.

Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from:

or the diamines and diisocyanates thereof, wherein each X represents a member independently selected from —CH₂COO— (glycolic acid moiety), —CH(CH₃)COO— (lactic acid moiety), —CH₂CH₂OCH₂COO— (dioxanone), —CH₂CH₂CH₂CH₂CH₂COO— (caprolactone moiety), —(CH₂)_yCOO— where y is one of the numbers 2, 3, 4 or 6-24 inclusive, and —(CH₂CH₂O)_z′CH₂COO— where z′ is an integer between 2 and 24, inclusive; each Y represents a member independently selected from —COCH₂O— (glycolic ester moiety), —COCH(CH₃)O— (lactic ester moiety), —COCH₂OCH₂CH₂O— (dioxanone ester), —COCH₂CH₂CH₂CH₂CH₂O— (caprolactone ester), —CO(CH₂)_mO— where m is an integer between 2, 3, 4 or 6-24 inclusive, —COCH₂O(CH₂CH₂O)_n— where n is an integer between 2 and 24, inclusive; R′ is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; p is an integer between 1 and 4, inclusive; and Rn represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid and —NO₂, which is attached directly to an aromatic ring or attached through an aliphatic chain. Absorbable polymers prepared from these compounds are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention and other implantable medical devices.

The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymer compositions comprise polymerized silicon-containing monomers end-capped with polymerizable cationic hydrophilic groups.

The invention discloses a preparation method of multiple cross-linked polysaccharide injectable hydrogel. Modified water-soluble chitosan with carboxyl or hydroxyl groups as a first component and a hydroformylation-modified polysaccharide polymer or polysaccharide polymer mixer as a second component produce electrostatic action with each other and undergo a Schiff-base reaction to produce the hydrogel with a multiple cross-linked net structure. The multiple cross-linked polysaccharide injectable hydrogel has gelling time of 5-200s and has good mechanical properties. Through change of a chitosan and polysaccharide modification rate, a mole ratio of two components and solid content of hydrogel, gelling time, mechanical strength, microscopic morphology and water content are adjusted and controlled. The gel network contains a large amount of amino, carboxyl and aldehyde groups as active groups, the active groups can be bonded to drugs and proteins by covalent bonds, the multiple cross-linked polysaccharide injectable hydrogel as a novel medical material with excellent biocompatibility has a good application prospect in the fields of regeneration medical science, tissue engineering and drug controlled release.

Provided herein are catalysts useful in providing foam products which are produced using an organic poly isocyanate as a starting material. A catalyst according to the present invention includes the tris-(hydroxyethyl)methyl ammonium cation, and optionally potassium cation, in combination with a variety of possible counter anions present to maintain charge balance and for compatibility. A catalyst according to the invention is preferably used in conjunction with one or more conventional tertiary amine catalysts in a foam producing process. The foams may be polyurethane foams, polyisocyanurate foams, flexible foams, or elastomeric foams.

The present invention teaches a novel approach of creating biocmpatible surfaces, said surfaces being capable of functionally interact with biological material. SAid biocompatible surfaces comrise at least two comonents, such as a hydrophobic substratum and a macromolecule of hydrophilic nature, which, in a cooperativity, form together the novel biocoompatible surfaces. The novel approach is ased on contacting said hydrophobic substratum with a laterally patterned monomolecular layer of said hydrophilic and flexible macromolecules, exhibiting a pronounced excluded volume. The htus formed two component surface is, in respect to polarity and morphology, a molecularly heterogeneous surface. Structural features of said macromolecular monolayer (as e.g. the layer thickness or its lateral density) are determined by: i) the structural features of the layer forming macromolecules (as e.g. their MW or their molecular architecture) and ii) the method of creating said monomolecular layer (as e.g. by physi- or chemisorbing, or by chemically binding said macromolecules). The structural features of the layer forming macromolecules(s) is in turn determined by synthesis. AMount and conformation and thus also biological activity of biological material (as e.g. polypeptides) which contact the novel biocompatible surface, is determined and maintained by the cooperative action of the underlying hydrophobic substratum and the macromolecular layer. In this way it becomes possible to maintain and control biological interactions between said contacted polypeptides and other biological compounds as e.g. cells, antibodies and the like. Consequently, the present invention aims to reduce and/or eliminate the deactivation and/or denaturation associated with the contacting of polypeptides and/or other biological material to a hydrophobic substratum surface.

The invention discloses a silk fibroin nanofiber membrane and a preparation method of the silk fibroin nanofiber membrane. The preparation method comprises the following specific steps of: dissolving natural silk taken as a main raw material by an acid salt solution, forming a membrane, desalting the membrane, dissolving the membrane by methanoic acid and hexafluoroisopropanol to prepare a spinning solution, and carrying out electrostatic spinning to prepare the silk fibroin nanofiber membrane. The silk fibroin nanofiber membrane comprises fibers with the diameter of 10nm-10 microns and has the excellent mechanical property, the breaking strength of greater than 8Mpa at dry state, the breaking elongation of greater than 15% at dry state, the breaking strength of greater than 1Mpa at wet state and the breaking elongation of greater than 100% at wet state. In addition, the silk fibroin nanofiber membrane prepared by the method is stable and controllable in structure, has good biocompatibility and can serve as a medicinal biological material. The preparation method disclosed by the invention is simple and short in flow path, has high film formation and spinning efficiency and is suitable for industrialization large-scale production.

A surgical tissue adhesive composition contains at least one 1,1-disubstituted electron-deficient olefin macromer. The adhesive composition of the invention has improved biocompatibility as well as controlled biodegradation characteristics and bioactivity. Adhesive co-monomer compositions contain at least one macromer with a pendant oligomer, polymer, or peptide chain as an acrylic ester of the reactive olefin. The polymers formed therefrom have a grafted brush-like nature. The composition is particularly useful for creating an adhesive bond at the junction of living tissue in surgical applications. The adhesive composition may further comprise co-monomer, co-macromer, cross-linker, or inter-penetrating polymer compounds containing peptide sequences that are bioactive or enzyme responsive. The peptide sequences are selected to promote tissue infiltration and healing in a particular biological tissue. The sequences may contain specific cell-adhesion, cell-signaling, and enzyme-cleavable domains. Furthermore, a degradable filler material may be included in the composition to create a reinforced composite. The filler preferably has a higher degradation rate than the polymer matrix, generating porosity upon degradation. The adhesive may further contain entrapped or incorporated drugs or biologics, including antibiotics or growth factors. The adhesive can be used to bind together the edges of living tissues during surgical procedures. The cured composition provides interfacial bonding and mechanical fixation while promoting tissue infiltration and replacement of the adhesive polymer.

The invention discloses a method for preparing graphene modified by a silane coupling agent. The method includes adding graphite oxide and the silane coupling agent into reaction solvent, controlling the temperature to range from 0 DEG C to 90 DEG C, realizing stirred reaction for 0.1 to 72 hours and obtaining graphite oxide grafted with the silane coupling agent; adding the graphite oxide grafted with the silane coupling agent into reduction solvent, adding a reducer into the reduction agent, controlling the temperature to range from 0 DEG C to 90 DEG C, realizing stirred reduction reaction for 0.1 to 72 hours and obtaining graphene liquor grafted with the silane coupling agent; and treating the graphene liquor grafted with the silane coupling agent and then obtaining solid graphene powder modified by the silane coupling agent. The mass ratio of the graphite oxide and the silane coupling agent is 1:0.1-5. The technological method is simple and speedy, requirements on reaction conditions are low, a process is easy to control, and the graphene modified by the silane coupling agent can be obtained without catalysts or multi-step complicated reaction. The graphene is fine in polymer compatibility and simple in preparation and can be widely applied to fields of preparation of graphene modified polymers and novel electrochemical electrodes and novel optical and conductive materials, raw materials are easily available, and a product has good dispersibility in partial organic solvent.

The invention discloses a biomacromolecule interpenetrating polymer network hydrogel and a preparation method of the biomacromolecule interpenetrating polymer network hydrogel. The biomacromolecule interpenetrating polymer network hydrogel is formed by crosslinking two kinds of enzymes in a catalysis mode, one is a polysaccharide macromolecule network formed by crosslinking polysaccharide macromolecules with introduced phenolic hydroxyl groups in an oxidation mode as oxidase and hydrogen peroxide catalyze phenolic hydroxyl groups, and the other is a protein or polypeptide macromolecule network formed crosslinking protein or polypeptide containing amino acid residues as transferase catalyzes peptide bonds. The two networks interpenetrate each other and form the novel interpenetrating polymer network hydrogel without bonding of chemical bonds. No chemical crosslinking agent is used in the hydrogel, and the hydrogel has excellent biocompatibility and mechanical property, can be shaped like a dry or wet film, like porous sponge or fibers, and can serve as a contact lens, a medicine release carrier, a scaffold for tissue engineering or materials for tissue repair.

Fatty alcohol or aliphatic glycol-grafted rubber-like silicone gels with enhanced oil compatibility are synthesized by 1) reacting a fatty alcohol or a aliphatic glycol with methylhydrodimethylsiloxane copolymer in the presence of a platinum catalyst in a reaction medium of a silicone fluid or a cosmetic oil or a mixture thereof, and 2) further reacting the mixture with a vinyl-functional siloxane polymer. The resulting compounds may be used as gelling agents for hydrocarbon oils, vegetable oils and silicone oils. The efficient synthetic process approaches a 100% yield.

A dispersion includes a plurality of non-chemically modified carbon nanotubes, a soluble block copolymer providing at least one block of a conjugated polymer and at least one block of a non-conjugated polymer, and at least one solvent. At 25° C. exclusive of any mechanical force and after one hour, at least 90% of the plurality of carbon nanotubes exist in the dispersion as isolated carbon nanotubes. The components of the dispersion can be combined with a polymer miscible with the block copolymer to form a carbon nanotube polymer composite upon removal of the solvent. The dispersion can be cast on a substrate and then dried to form a coating, including forming a superhydrophobic coating on the substrate. The non-conjugated polymer of the block copolymer or another miscible conjugated polymer including a copolymer can include functionalities that non-covalently attach to the carbon nanotube surface, such as for manipulating carbon nanotube properties including for enhanced solubility or enhanced biocompatibility.

The present application teaches a coating having a biologically compatible compound conjugated to, or blended with, a polymer, wherein the polymer includes at least one olefin-derived unit and at least one unit derived from a vinyl alcohol, an allyl alcohol, or derivatives thereof.

A medical film that is excellent in biocompatibility and bioabsorbability and has an excellent strength in suturing and bonding is provided. A reinforcing material 12 made of a biodegradable polymer is placed in a gelatin solution so as to allow the solution to infiltrate in the reinforcing material 12 and then the gelatin is dried. This allows the gelatin that has infiltrated entirely in an internal part of the reinforcing material 12 to gel, thereby forming a gelatin film 11. Thus, a medical film 1 in which the reinforcing material 12 and the gelatin film 11 are integrated is obtained. The gelatin film 11 preferably is a cross-linked gelatin film.

The nanoscopic dimensions of polyhedral oligomeric silsesquioxanes (POSS) and polyhedral oligomeric silicates (POS) materials ranges from 0.7 nm to 5.0 nm and enables the thermomechanical and physical properties of polymeric materials to be improved by providing nanoscopic reinforcement of polymer chains at a length scale that is not possible by physically smaller aromatic chemical systems or larger fillers and fibers. A simple and cost effective method for incorporating POSS/POS nanoreinforcements onto polymers via the reactive grafting of suitably functionalized POSS/POS entities with polymeric systems amenable to such processes is described. The method teaches that the resulting POSS-grafted-polymers are particularly well suited for alloying agents by nongrafted POSS entitles such as molecular silicas. The successful alloying of POSS-polymers is aided because their interfacial tensions are reduced relative to non-POSS containing systems.

The invention relates to a preparation method of a slow-setting polycarboxylic acid water reducing agent, which is implemented by carrying out free radical copolymerization reaction on allylsulfonate monomers, acrylic monomers, polyethylene glycol nono-methyl ether methacrylate macromonomers and maleic anhydride grafted beta-cyclodextrin macromonomers. The invention is characterized in that a beta-cyclodextrin side chain is introduced into a polycarboxylic acid main chain, so that the polycarboxylate water reducing agent has favorable slow setting property, micro air-entraining property and better fluidity. The obtained polycarboxylic acid water reducing agent has the advantages of stable product performance, strong adaptability to cement and favorable compatibility; and the cement paste fluidity is up to higher than 290mm (W/C=0.29), the water reducing rate of concrete is up to 30-40%, and the slump protection time is 3-5 hours. The preparation method provided by the invention has the characteristics of unique technique, excellent product performance and the like.

The invention discloses a preparing method for infrared response high-strength hydrogel for cartilago articularis repair. The preparing method mainly includes the operation steps that polysaccharide or protein is modified in a double bond forming mode through methacrylic acid, methacrylic anhydride and methacrylate substances, so that the polysaccharide or the protein has a double-bond group in a side chain and is capable of being polymerized to form the hydrogel. Under the action of an initiator and a cross-linking agent, N-isopropyl acrylamide and the polysaccharide or the protein modified in the double bond forming mode form the double-network high-strength hydrogel through in-situ polymerization. The prepared infrared response high-strength hydrogel is high in biocompatibility and excellent in mechanical property and has good application prospects in the field of cartilago articularis repair.

A hydraulic cement for biomedical applications. The cement sets in-situ, hardening when exposed to water to produce nano-dispersed composite of calcium-silicate-hydrate gel mixed with hydroxyapatite. In comparison with prior cements, the composition provides high biocompatibility, high bioactivity and high biomechanical strength, due to the composite structure of the calcium silicate hydrate reinforced with co-precipitated particles of hydroxyapatite. Biocompatibility is also increased due to an absence of aluminum and magnesium in the composition. The cement is suitable for variety of applications, including dental implants, bone fixation, and bone repair.

The invention provides a self etching adhesive dental primer composition, a method of use of the primer composition and a product formed from the primer. The dental product is formed from the primer composition which includes water, surfactant and polymerizable material in suspension in the water. The polymerizable material includes monomers which are water immiscible. Preferably the monomers have an average molecular weight less than 1000. The primer composition is used by applying the composition to unetched dental tooth enamel and the polymerizable material is polymerized to form a dental product having adhesion to the enamel of more than 13 MPa. Improved surfactants which contain at least one ethenically unsaturated polymerizable group are provided in accordance with the invention. Surfactants of the present invention copolymerize with and become an integral part of any polymerizable resin matrix in which they are incorporated. This prevents migration of the surfactant through the matrix or slow leaching-out through the interfaces, and brings advantages of biocompatibility and stability of the physical properties of the cured matrix. In addition, the surfactant becomes a permanent part of the matrix, and forms part components of the matrix.

The invention discloses a high-thermal-diffusion-coefficient high molecular material and a preparation method thereof. The high-thermal-diffusion-coefficient high molecular material is prepared from the following steps: 20-65 parts of matrix resin, 35-65 parts of high-thermal diffusion heat-conducting filler, 0.1-5 parts of carbon fiber composite, 0.1-10 parts of a flexibilizer, 0.1-2 parts of coupling agent, 0.1-2 parts of antioxidant and 0.1-15 parts of other auxiliaries. According to the high-thermal-diffusion-coefficient high molecular material, the heat conduction capability of the high molecular material is remarkably enhanced by virtue of the positive synergetic hybrid effect of a three-dimensional heat-conducting network formed by the high-thermal-diffusion-coefficient heat-conducting fillers different in shape in the processing course, and therefore the problems of poor heat conduction and thermal diffusion properties of the high molecular material for the existing LED lamp cooling housing are solved; in the preparation process, the compatibility between the surface modified high-thermal-diffusion-coefficient high molecular material and a resin matrix is improved, the viscosity of the synthetic resin melt is reduced and the dispersity of the filler is improved to enhance the processability; as a result, the product has excellent surface quality and mechanical properties; the high molecular material further has the advantages of high thermal conductivity and high tenacity.

A poly(2,6-dimethyl-1,4-phenylene ether) prepared using a morpholine-containing polymerization catalyst has a monomodal molecular weight distribution with a reduced content of very high molecular weight species. It also exhibits increased morpholine incorporation in the high molecular weight fraction. Compared to commercially available poly(2,6-dimethyl-1,4-phenylene ether) prepared using a di-n-butylamine-containing polymerization catalyst, the poly(2,6-dimethyl-1,4-phenylene ether) of the invention exhibits reduced odor. Compared to other poly(2,6-dimethyl-1,4-phenylene ether) prepared using a morpholine-containing polymerization catalyst, the poly(2,6-dimethyl-1,4-phenylene ether) of the invention exhibits improved molecular weight build during compounding and improved compatibilization with polyamides.

The invention relates to a phosphorus-containing fire retardant, a preparation method of the phosphorus-containing fire retardant and a flame-retardant epoxy resin prepared from the phosphorus-containing fire retardant, and especially relates to a phosphorus-containing nitrile/DOPO double-base structure phosphorus-containing fire retardant, a preparation method of the phosphorus-containing nitrile/DOPO double-base structure phosphorus-containing fire retardant, and flame-retardant epoxy resin prepared from the phosphorus-containing nitrile/DOPO double-base structure phosphorus-containing fire retardant. The flame-retardant epoxy resin solves the problem that the existing epoxy resin has low flame retardation efficiency and poor compatibility between a polymer matrix and a fire retardant. The preparation method comprises the following steps of 1, dissolving p-hydroxybenzaldehyde and tetrahydrofuran, adding triethylamine into the solution and carrying out stirring, 2, dissolving phosphonitrilic chloride trimer in tetrahydrofuran, dropwisely adding the solution into the reaction system, and carrying out heating and stirring, 3, cooling the reaction system, concentrating the filtrate, pouring the filtrate into water for precipitate separation, carrying out pumping filtration, carrying out recrystallization on the precipitates and carrying out drying to obtain intermediates, and 4, dissolving the intermediates by a solvent, adding p-aminophenol into the solution, carrying out heating reflux, adding DOPO into the reflux product, carrying out condensation, pouring the concentrate into cold ethanol for solid precipitation, and washing and drying the solids to obtain the phosphorus-containing nitrile/DOPO double-base structure phosphorus-containing fire retardant. The flame-retardant epoxy resin comprises epoxy resin, a curing agent and the phosphorus-containing nitrile/DOPO double-base structure phosphorus-containing fire retardant. The preparation method is used for preparing the phosphorus-containing nitrile/DOPO double-base structure phosphorus-containing fire retardant.

The invention comprises self-lubricating polymer compositions that are especially useful in medical devices and valves and gaskets of medical devices. In a preferred embodiment, the polymer compositions comprise a thermosetting or thermoplastic silicone elastomer in combination with a lubricity enhancing polyfluoropolyether fluid or hydrocarbon-based synthetic oil. In other preferred embodiments, the polymer compositions contain only biocompatible components. The improved anti-friction properties of the self-lubricating polymers can be demonstrated over a course of insertion and withdrawal cycles, where conventional polymers have changing and mostly increasing force required for each insertion and withdrawal, while the polymer compositions of the invention remain stable.

The invention discloses a full-biodegradable composite as well as a preparation method and application of the full-biodegradable composite. The full-biodegradable composite comprises the following components: 5-40 parts of inorganic filler full-biodegradable masterbatches, 40-80 parts of biodegradable copolyester, 10-40 parts of polylactic acid and 0.1-5 parts of a compatilizer, wherein the inorganic filler full-biodegradable masterbatches comprise the following components: 20-80 parts of the biodegradable copolyester, 20-80 parts of inorganic filler, 0.1-10 parts of a lubricating agent and 0.1-5 parts of the compatilizer; and the inorganic filler is one or a combination of modified kaolin, modified white carbon black and modified montmorillonite. According to the full-biodegradable composite, the modified montmorillonite, the modified kaolin or the modified white carbon black is added as an enhancer, and an epoxy acrylic copolymer is introduced as the compatilizer, so that the compatibility of inorganic filler and matrix resin is enhanced, and the uniform dispersion is achieved; and the masterbatches are added into the matrix resin, so that the problem of relatively low tearing strength of a blend film and a sheet can be effectively improved.

Improved thermoplastic polymer blend compositions comprising an isotactic polypropylene component and an alpha-olefin and propylene copolymer component, said copolymer comprising crystallizable alpha-olefin sequences. In a preferred embodiment, improved thermoplastic polymer blends are provided comprising from about 35% to about 85% isotactic polypropylene and from about 30% to about 70% of an ethylene and propylene copolymer, wherein said copolymer comprises isotactically crystallizable propylene sequences and is predominately propylene. The resultant blends manifest unexpected compatibility characteristics, increased tensile strength, and improved process characteristics, e.g., a single melting point.

The invention relates to a method for preparing a sodium alginate-chitosan nano-grade medical dressing, and belongs to the field of natural biological polymer materials. The method comprises the following steps: dispersing sodium alginate and synthesized polymer in an ethanol solution; and preparing a chitosan solution containing a crosslinking agent to serve as a receiving liquid, wherein fibers are cross-linked by the crosslinking agent after the sodium alginate fibers are received in the chitosan solution, the electrolyte property of the chitosan is adsorbed to the surfaces of the sodium alginate fibers due to the electrostatic effect, and the prepared sodium alginate-chitosan composite nano-fibers have good air permeability and antibacterial and hemostasis effects, is advantageous to wound tissue growth and regeneration when being applied to a wound dressing, and can be used for accelerating wound healing. The method adopts a natural polymer matrix as a raw material, and the medical dressing has low cost, no toxicity and good biocompatibility.