278 results about "Star polymer" patented technology

The invention relates to a hyaluronan and biodegradable high polymer modified material and a preparation method, in particular to a method for complex crosslinking and grafting of the hyaluronan and a derivative thereof with a biodegradable high polymer with active functional groups through a crosslinking agent. The method comprises the steps of taking the hyaluronan and the biodegradable high polymer as raw materials, conducting complex crosslinking or grafting reaction of a hyaluronan aqueous solution and at least one biodegradable high polymer solution with the presence of the crosslinking agent, and removing a solvent. According to the method, plural gel, an amphiphilic polymer, a graft polymer, a star polymer and a microsphere can be prepared. The method has the advantages that the reaction condition is simple, the utilization ratio of the crosslinking agent is high, the residual quantity of the crosslinking agent is small, and the gel is higher in thermostability and good in biological compatibility. The method is applicable to the fields of cosmetics, tissue filling and repair, biological stents, ophthalmonogy, sustained-release delivery and targeted drug delivery and the like, and has a wider application prospect.

Conductive polymers having a star structure comprising a central core with multiple attachment sites and conjugated charge transporting arms radiating therefrom. The cores are derived from hyperbranched polymers, dendrimers, or other molecules with a multiplicity of attachment sites. The arms are derived from conjugated oligomers and polymers such as polythiophene, polyaniline or polyphenylene. The subject polymers allow assembly of the macromolecules in all three dimensions in the solid state. A ramification of the compact assembly is the realization of highly reflective, smooth coatings simply applied from solution. A preferred embodiment having a 1,3,5 hyperbranched polyphenylene core and poly (3-hexylthiophene) arms provides lustrous reflective gold coatings.

In one embodiment the present invention provides for a high thermal conductivity highly structured resin that comprises a host highly structured resin matrix, and a high thermal conductivity filler 30. The high thermal conductivity fillers are from 1-1000 nm in length, and high thermal conductivity fillers have an aspect ratio of between 3-100. Particular highly structured highly structured resins include at least one of liquid crystal 40 polymers, interpenetrating networks, dendrimer type matrices, expanding polymers, ladder polymers, star polymers and structured organic-inorganic hybrids 60.

One aspect of the invention provides a degradable / biocompatible elastomer. The elastomer comprises a degradable cross-linked network of a hydrophobic, hydrolysable amorphous star polymer and a hydrophilic, biocompatible polymer. The network may be crosslinked thermally or by irradiation. In a preferred embodiment, the elastomer is used for a drug delivery system, and is particularly useful for delivery of peptide and protein drugs.

The invention belongs to the technical field of polymer material synthesis and preparation, relating to a star-shaped comb butadiene / styrene segmented copolymer, which is characterized in that the copolymer has the following structure: An-C, wherein A is the butadiene / styrene segmented copolymer, C is star-shaped seed tree coupler residue which is an epoxidation liquid star-shaped copolymer, n is branching degree which is larger or equal to 3, the number average molecular weight of the star-shaped comb segmented copolymer An-C is 5*10<4>-50*10<4>, the number average molecular weight of the segmented copolymer A is 1*10<4>-15*10<4>, the content of styrene is 55 percent to 85 percent (weight percent, same below), the content of butadiene is 15 percent to 45 percent, the content of 1, 2-structure is less than 30 percent (weight percent, which is counted by 100 percent of the total amount of monomer butadiene). The synthesis has the effect and benefit of simplifying the synthetic route of the star-shaped comb butadiene / styrene segmented copolymer, which can be widely applied to the preparation of the star-shaped comb butadiene / styrene segmented copolymer.

Generally, and in one form, the present invention is a composition of light-emitting block copolymer. In another form, the present invention is a process producing a light-emitting block copolymers that intends polymerizing a first di(halo-methyl) aromatic monomer compound in the presence of an anionic initiator and a base to form a polymer and contacting a second di(halo-methyl) aromatic monomer compound with the polymer to form a homopolymer or block copolymer wherein the block copolymer is a diblock, triblock, or star polymer. In yet another form, the present invention is an electroluminescent device comprising a light-emitting block copolymer, wherein the electroluminescent device is to be used in the manufacturing of optical and electrical devices.

The invention discloses a preparation method of a star polymer, belonging to the technical field of petroleum extraction. The method adopts a redox initiation system, and carries out water solution radical copolymerization on three water-soluble monomers, including tert-butyl acrylate, 2-acrylamido-2-methylpropane sulfonic acid and acrylamide. The redox initiation system comprises trihydroxymethyl phenol, persulfate, hydrogen peroxide, urea, sodium formaldehyde bisulfite, azoisobutyronitrile, chain transfer agent and surfactant. The molecular weight of the star polymer prepared by the method is 8-15 million; the star polymer is water-soluble; the content of the residual monomers in the product is less than or equal to 0.1 wt%; and the star polymer and a crosslinking system, which is composed of water-soluble phenolic resin and polyethylene imine, can form a movable gel system for carrying out deep profile control on a high-temperature high-salt oil reservoir of which the salinity is 117000 mg / L and the temperature is 140 DEG C.

The invention discloses a star polymer nano-medicament carrier preparation used for intracellular medicament delivery. The nano-medicament carrier preparation is characterized by comprising the following components in part by weight: 1 to 20 parts of medicament, 10 to 200 parts of amphiphilic star segmented copolymer, and 20 to 500 parts of organic solvent, wherein the amphiphilic star segmented copolymer in the carrier is formed from hydroxyl-terminated star aliphatic polyester by connecting a hydrophilic segment through a disulfide bond. By using a self-assembling behavior of the copolymer in aqueous solution, nanoparticles of which internal hydrophobic layers coat the medicament can be prepared by a dialysis method. After entering cells, the nano-medicament carrier can prompt a hydrophilic shell thereof to drop selectively by using a reducing environment in tumor cells so as to realize localized release of the medicament in the tumor cells.

The invention discloses a biological adhesive which comprises a component a, and a component b, wherein the component a is a functional star polymer or / and a functional comb-like polymer, the functional star polymer is provided with one or more active groups, and the functional comb-like polymer is provided with one or more active groups; the component b is a functional polysaccharide which is provided with one or more active groups; and chemical reactions can be carried out between the active groups of the component a and the active groups of the component b so as to form novel chemical bonds. The invention further discloses a preparation method and application of the biological adhesive. The biological adhesive disclosed by the invention is a biocompatible adhesive (glue) formed by rapidly reacting the functional star polymer or / and comb-like polymer with lots of active groups and the functional polysaccharide. The adhesive based on the star polymer or / and comb-like polymer has a star or / and comb structure and has lots of active reactive groups, so that the gel forming reaction is fast, and the adhesive is reacted with tissues so as to realize an adhesive effect.

A silane or carbosilane dendrimer is modified with bridge moieties and polymer arms attached to the bridges to form hybrid dendrimer-star polymers. The bridge moieties are attached via Si-C bonds to the silane or dendrimer. The bridge has one or more reactive groups to which polymer arms are attached. Selected reactive groups on the bridge may serve as initiator sites for in situ polymerization of the arms. The polymer arms are of the polyether, polysulfide or polyester type. These arms may have functional groups which allow further modification and attachments. For this type of star polymer, the bridge has been found to increase resistance to hydrolysis at the silane- or dendrimer-arm junction. These star polymers are useful e.g. as viscosity modifiers, component in molding resins, water solubilizer for hydrophobic molecules, surfactants and as carriers for drugs, prodrugs and other biological agents.

Lubricating oil compositions and viscosity index (VI) improver concentrates containing combinations of first polymers that are amorphous ethylene α-olefin copolymers; and second polymers that are star polymers, the arms of which are derived from diene, and optionally vinyl aromatic hydrocarbon monomer, wherein the star polymers have a Shear Stability Index (SSI) of from about 1% to about 35% (30 cycle).

The invention discloses a star polymer used as a lubricating oil viscosity index improver, a preparation method of the star polymer and application of the star polymer. The star polymer has asymmetrical arms and consists of two different types of polymer arms, wherein the first type of polymer arm is a hydrogenation polyisoprene homopolymer, and the second type of polymer arm is a copolymer in a hydrogenation polyisoprene-hydrogenation polybutadiene-polystyrene block structure; and in the copolymer arm, the polystyrene section is close to the core of the star polymer, the hydrogenation polybutadiene section is in the middle of the arm, and the hydrogenation isoprene section is outside the arm. The structure of the star polymer contains 2-15% of polybutadiene block by weight, and at least a part of the polyisoprene block and the polybutadiene block in the structure of the start polymer is hydrogenated. The star polymer has an excellent tackifying effect and excellent shear resistance stability, and is lower in pumping viscosity and low-temperature start viscosity during blending of thickened engine oil, and crystal or gel cannot be formed in the engine oil by the star polymer.

The invention discloses a self-emulsifying molecular antifoaming agent and a preparation method thereof. The antifoaming agent comprises the following components in percent by mass: 20 to 60 percent of antifoaming active substance and 40 to 80 percent of dispersion medium, wherein the antifoaming active substance consists of higher fatty alcohol, alkynol, polyether and silicone oil in a mass ratio of 1:(0.8-1.5):(2-3):(2-4); and the dispersion medium is grafted star polymer. The preparation method comprises the following steps of: adding 50 to 150 parts of trichloromethane and 1 to 2 parts ofp-methyl benzene sulfonic chloride into 20 to 60 mass parts of active substance and 40 to 80 mass parts of star polymer, raising the temperature to between 40 and 70 DEG C, and reacting for 3 to 6 hours; and after the reaction is finished, washing sodium carbonate until the ph is 7, drying by using anhydrous sodium sulfate, and evaporating the solvent under reduced pressure to obtain the antifoaming agent. The extended arm of the star polymer in the antifoaming agent is grafted with the active substance, so that various components are synergistic, and the obtained antifoaming agent is high instability, low in surface tension, high in surface activity, high in antifoaming capacity, long in foam inhibition time and small in dosage.

The invention relates to a novel preparation method and application of a cationic amphiphilic tetra-armed star polymer. In particular, the star polymer can be obtained through synthetic means such as atom transfer radical polymerization (ATRP) and click chemistry. A core of the star polymer is tetraphenylethylene with the characteristic of aggregation-induced emission. A polymer linear arm is a cationic amphiphilic random copolymer with excellent antibacterial effects. A covalently labeled T1 type magnetic resonance (MR) contrast agent is an organic gadolinium chelate. By using the cationic amphiphilic tetra-armed star polymer, fluorescence / MR double quantitative detection of Gram positive and negative bacteria with negative charges on the surfaces in the environment of pure water is achieved, and meanwhile good antibacterial effects are gained.

The invention discloses a chemically mechanical polishing solution and application thereof. The chemically mechanical polishing solution comprises star polymer containing pigment affinity group, ground granules, complexing agent, oxidant and water. By using the inventive polishing solution, flaws of copper billets can be reduced, partial and entire corrosion of the meal copper can be prevented, and the static corrosion velocity of copper at normal temperature and polishing temperature can be reduced under the condition of maintaining higher copper removal velocity.

The synthesis and characterization of star copolymers by living carbocationic copolymerization of statistical polymers comprising monomers of isobutylene (IB) and another monomer selected from the group consisting of styrene, isoprene and living carbocationically copolymerizable derivatives thereof is described. The poly(isobutylene-co-styrene) arms emanate from a calix[n]arene core where n preferably equals 8, forming an multi(octa)-arm star. The arms are advantageously fitted with crosslinkable termini such as allyl or hydroxyl end groups. The hydroxyl-terminated arm star copolymers are particularly suitable for use in coatings when reacted with crosslinking agents such as isocyanates.

A preparation method of hydrophobically modified sodium alginate gel belongs to the technical field of biomedical materials. The invention prepares a star polymer which contains inorganic matter and hydrophobic polymers; the prepared polymer is ultrasonically dispersed into a sodium alginate solution by ultrasonic dispersion technology; and a calcium alginate hybrid gel with both hydrophobicity and hydrophilicity is prepared by a dropping liquid method. A hydrophobic drug of ibuprofen has a high embedding rate of up to above 90% in the gel, and has a good sustained release effect with a drug release amount of the first 2 hours being reduced by nearly 45%; the problem is overcome that since sodium alginate has strong hydrophilicity and the loading amount for hydrophobic drugs is less, burst release is easy to occur in an early stage of drug release. The drug-loaded microsphere of the invention is convenient for preparation, controllable in particle size (about 1 mm), good in biocompatibility, has no toxicity to human body, and has potential application value for being used as a drug carrier.

Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as cisplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, liver cancer, kidney cancer, or prostate cancer) in a subject.

Belonging to the technical field of biomedical polymer materials, the invention discloses a beta-cyclodextrin based amphiphilic pH responsive star polymer and a preparation method thereof, a micelle system based thereon, a composite material and application thereof. The polymer has a structure shown as the formula (1) in the specification, wherein x=3-20, y=2-30, z=5-35, and n=2-10. The polymer can be reduced in situ to obtain nanogold with small particle size and good stability. The invention also provides a micelle system based on the polymer, the micelle system has strengthened entrapment ability to water-insoluble drugs, can efficiently load hydrophobic drugs, gold nanoparticles and other substances, realizes the combination of tumor imaging diagnosis and tumor chemotherapy, and improves the therapeutic efficiency of cancer. And the polymer is easy to control the proportion of each block, and can be applied to preparation of the water-insoluble drug loaded micelle system to satisfy the release requirements of different drugs.

The invention provides compositions of matter, methods of their synthesis, and methods of their use in polymerization reactions. The compositions include polyfunctional initiators used to make star polymers when polymerized with monomers. The polyfunctional initiators are synthesized out of a multifunctional core with at least two functional groups and two or more initiator units bonded to the functional groups. The initiator units have two electron-withdrawing groups bonded to a central carbon atom and an azo group between the central carbon atom and the functional group. The polyfunctional initiators are particularly effective because when they decompose to form the radical core of a star polymer, the electron-withdrawing groups prevent the corresponding radical from forming any linear polymer contamination and only desired star polymers result. In addition when the desired star polymers are fed into a reaction vessel by streams with two different concentrations the star polymers produce superior properties.

Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as cisplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, liver cancer, kidney cancer, or prostate cancer) in a subject.

The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization CLICK chemistry and a tetrafunctional initiator having terminal halogen groups to form the desired product.

The invention belongs to the field of macromolecular materials and biomedical engineering, and particularly relates to a preparation method of a star polymer-based drug carrier material with fluorescence labeling and temperature responsiveness. The preparation method comprises the following steps: carrying out ring opening polymerization on a cyclo-carbonate monomer serving as a raw material by using a star initiator to prepare a star polyester macromolecular material, and carrying out reaction on the star polyester macromolecular material and 2-bromoisobutyryl bromine to prepare a star macromolecular initiator; introducing a hydrophilic monomer with temperature responsiveness into the macromolecular initiator through atom transfer radical polymerizationto prepare an amphipathic segmented copolymer with temperature responsiveness, and introducing a methacrylic acid hydroxyethyl monomer through the atom transfer radical polymerization to provide a hydroxyl; and preparing the star polymer-based drug carrier material with fluorescence labeling and temperature responsiveness by the chemical reaction between the hydroxyl and fluorescent small molecules. The material can be self-assembled into a fluorescence labeled nano drug carrier micelle in an aqueous solution, and has good application prospects in the fields of cancer chemotherapy, drug transportation, distribution and monitoring and the like.

Polymers suitable for use as a viscosity index improver for lubricating oil compositions including linear polymers characterized by the formula:D′-PA-D″;and star polymers characterized by the formula:(D′-PA-D″)n-X;wherein D′ represents an “outer” block derived from diene having a number average molecular weight of from about 10,000 to about 120,000 daltons; PA represents a block derived from monoalkenyl arene having a number average molecular weight of from about 10,000 to about 50,000 daltons; D″ represents an inner random derived from diene having a number average molecular weight of from about 5,000 to about 60,000 daltons; n represents the average number of arms per star polymer formed by the reaction of 2 or more moles of a polyalkenyl coupling agent per mole of arms; and X represents a nucleus of a polyalkenyl coupling agent.

The present invention includes star polymers which can be used as viscosity index improvers in oil compositions formulated for high performance engines. The star polymers have tetrablock copolymer arms of hydrogenated polyisoprene-polybutadiene-polyisoprene with a block of polystyrene and which provide excellent low temperature performance in lubricating oils, exhibit good thickening efficiency, and are finishable as polymer crumb.

The invention belongs to the technical field of high polymer chemistry and pharmaceutical preparations, relates to a synthesis and a micellization application of an amphiphilic beta-cyclodextrin (beta-CD) star polymer, and provides an amphiphilic beta-cyclodextrin (beta-CD) star polymer taking beta-cyclodextrin (beta-CD) as a core, acrylic acid and a methyl methacrylate copolymer as a lipotropy block and poly (N-vinyl pyrrolidone) as a hydrophilic block, and a synthesizing method of the amphiphilic beta-cyclodextrin (beta-CD) star polymer. The amphiphilic beta-cyclodextrin (beta-CD) star polymer is formed by connecting amphiphilic block polymers to 3-6 hydroxide radicals of the beta-cyclodextrin (beta-CD). The molar mass ratio of the acrylic acid and the methyl methacrylate in the lipotropy block and the poly (N-vinyl pyrrolidone) in the hydrophilic block in the amphiphilic polymer is 4:1:(1-15):1:16. The invention further relates to a vinpocetine micelle taking the amphiphilic beta-cyclodextrin (beta-CD) star polymer as a carrier material and a preparation method of the vinpocetine micelle. The medicine carrying micelle of the amphiphilic beta-cyclodextrin (beta-CD) star polymer provided by the invention has the characteristics of slow-release effect, pH sensitivity and lung targeting.

The invention discloses a star poly-(methyl)acrylate long-chain ester polymer and a preparation method thereof. In the method, through atom transferring radical polymerization, the poly-(methyl)acrylate long-chain ester polymer with a star molecular structure is synthesized in one step by using a simple and economical method of arm first and core later; and arm length and arm number are controlled by adjusting a ratio of a monomer (methyl) acrylates long-chain ester to a catalyst to a ligand, and the adding time and dosage of a crosslinking agent methylacrylic acid gylcol ester (EGDMA) during a polymerization reaction so as to obtain the star polymer with high yield, adjustable and controllable molecular weight, and narrow molecular weight distribution. The preparation method can synthesize the (methyl)acrylate long-chain ester star polymer of which the weight-average molecular weight reaches up to a million and the yield reaches over 85 percent, and has important significance for theory and practical application.

The invention discloses a topological structure liquid crystal polymer electrolyte, and a synthetic method and an application thereof. The electrolyte is composed of hyperbranched / star polymer and liquid crystal elements, with a topological structure as follows: FORMULA. The topological structure liquid crystal polymer electrolyte provided by the invention has the advantages that the electrolyte has good film-forming property, and can form solid polymer electrolyte after being compounded with lithium salt, and the solid polymer electrolyte has good ionic conductivity, excellent electrochemical performance and rate performance.