2480 results about "Ring-opening polymerization" patented technology

Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester on the bonded lactone. Biologically active agents may be deposited with the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.

Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of poly(lactide-co-caprolactone) copolymer on the bonded lactone. Biologically active agents may be disposed with the poly(lactide-co-caprolactone) copolymer layers. Such coated surfaces may be useful in medical devices, in particular stents.

Methods for efficient preparation of drug-polymer (or oligomer) conjugates which are useful in the preparation of particles, including microparticles and nanoparticles, for delivery of the drug in vivo for therapeutic applications. The invention additionally provides certain drug-polymer and drug-oligomer conjugates which are useful in the preparation of particles for delivery of the drug in vivo. The invention also provides nanoparticles of this invention prepared by nanoprecipitation using drug-polymer/oligomer conjugates of the invention.

The drug conjugates are formed during polymerization of the polymer or oligomer in which the drug is employed as an initiator of the polymerization of the monomers which form the polymer and/or oligomer. More specifically, the drug conjugates are formed by ring-opening polymerization of cyclic monomers in the presence of an appropriate ring-opening polymerization catalyst and the initiator (the drug). The method is particularly useful for formation of polymer/oligomer conjugates with drugs and other chemical species containing one or more hydroxyl groups or thiol groups.

Methods are disclosed of making linear and cross-linked, HMW (high molecular weight) polysilanes and polygermanes, polyperhydrosilanes and polyperhydrogermanes, functional liquids containing the same, and methods of using the liquids in a range of desirable applications. The silane and germane polymers are generally composed of chains of Si and/or Ge substituted with R′ substituents, where each instance of R′ is, for example, independently hydrogen, halogen, alkenyl, alkynyl, hydrocarbyl, aromatic hydrocarbyl, heterocyclic aromatic hydrocarbyl, SiR″₃, GeR″₃, PR″₂, OR″, NR″₂, or SR″; where each instance of R″ is independently hydrogen or hydrocarbyl. The cross-linked polymers can be synthesized by dehalogenative coupling or dehydrocoupling. The linear polymers can be synthesized by ring-opening polymerization. The polymers can be further modified by halogenation and/or reaction with the source of hydride to furnish perhydrosilane and perhydrogermane polymers, which are used in liquid ink formulations. The synthesis allows for tuning of the liquid properties (e.g., viscosity, volatility, and surface tension). The liquids can be used for deposition of films and bodies by spincoating, inkjetting, dropcasting, etc., with or without the use of UV irradiation. The deposited films can be converted into amorphous and polycrystalline silicon or germanium, and silicon or germanium oxide or nitride by curing at 400-600 DEG C. and (optionally) laser- or heat-induced crystallization (and/or dopant activation, when dopant is present).

A polymerization process comprising initiating a first polymerization of monomers using an initiator functionalized with an ATRP initiating site, wherein the first polymerization is selected from the group of cationic polymerization, anionic polymerization, conventional free radical polymerization, metathesis, ring opening polymerization, cationic ring opening polymerization, and coordination polymerization to form a macroinitiator comprising an ATRP initiating site and further initiating an ATRP polymerization of radically polymerizable monomers using the macroinitiator comprising an ATRP initiating site. Novel block copolymers may be formed by the disclosed method.

The invention discloses a preparation method of an all-solid polymer electrolyte through in-situ ring opening polymerization of an epoxy compound, and an application of the all-solid polymer electrolyte in an all-solid battery. The preparation method is characterized in that a liquid-state epoxy compound, a lithium salt, a battery additive and the like are employed as precursors and are injected into between a positive pole sheet and a negative pole sheet of the battery, and under a heating condition, in-situ polymerization solidification is carried out to form the all-solid polymer electrolyte, and furthermore, the all-solid battery is produced. The ionic conductivity at room temperature of the all-solid polymer electrolyte can reach from 1*10<-5> S/cm to 9*10<-3> S/cm and electric potential window is 3.5-5 V. The all-solid polymer electrolyte is prepared through the in-situ copolymerization method, so that the all-solid polymer electrolyte has excellent contact with electrodes, thereby greatly improving interface compatibility of the solid-state battery, reducing interface wetting and modification steps of the solid-state battery, reducing production cost of the solid-state battery and improving performances of the solid-state battery. The invention also discloses an all-solid polymer lithium battery assembled from the all-solid polymer electrolyte.

The invention relates to products and processes employing coupling activator compounds represented by the following formula I:

S—X-A  (I)

wherein S represents a silane coupling moiety capable of bonding with the surface of an inorganic substrate, A represents a ring-opening polymerization activator moiety, or blocked precursor thereof, and X represents a linking moiety. Substrates containing the coupling activator compounds are useful in preparing reinforced resins.

A polyoxyalkylene polyol or monool (I) of the general formula (1) below, in which not less than 40% of the terminally located hydroxyl-containing groups, namely -AO-H groups, are primary hydroxyl-containing groups of the general formula (2) below, or;a method of producing ring-opening polymerization products, by subjecting a heterocyclic compound to ring-opening addition polymerization with an active hydrogen-containing compound, using as a catalyst tris(pentafluorophenyl)borane, tris(pentafluorophenyl)aluminum, etc.

Polymers comprising a polymer backbone comprising one or more degradable units are described. The polymer may additionally comprise two or more polymer segments comprising radically (co)polymerizable vinyl monomer units. The degradable units may be independently selected from, but not limited to, at least one of hydrodegradable, photodegradable and biodegradable units between the polymer segments and dispersed along the polymer backbone. The degradable units may be derived from one or more monomers comprising a heterocyclic ring that is capable of undergoing radical ring opening polymerization, a coupling agent, or from a polymerization initiator, radically polymerizable monomers, as well as other reactive sources. Embodiments of the degradable polymer of claim are capable of degrading by at least one of a hydrodegradation, photodegradation or biodegradation mechanisms to form at least one of telechelic oligomer and telechelic polymeric fragments of the polymer. The degradable polymer may be able to degrade into polymer fragments having a molecular weight distribution of less than 5, or in certain applications it may be preferable for embodiments of the polymer to be capable of forming polymer fragments having a molecular weight distribution of the polymer fragments less than 3.0 or even less than 2.5. Embodiments of the present invention also include methods of producing degradable polymers.

A process for producing a hydrogenated product of a polymer prepared through ring-opening polymerization which comprises a polymerization step of polymerizing a cyclic olefin through ring-opening polymerization in the presence of a polymerization catalyst comprising an organoruthenium compound or an organoosmium compound to prepare a polymer, and a hydrogenation step of adding a hydrogenation catalyst and hydrogen into a polymerization system resulting from the polymerization step to hydrogenate the carbon-carbon double bonds of the polymer prepared through the ring-opening polymerization. When the organoruthenium compound- or organoosmium compound-containing catalyst further comprises a carbene compound, the catalyst exhibits a higher activity for the ring-opening polymerization.

The invention discloses a method for preparing a perdurable hydrophilic polyether modified amino-polysiloxane softener. The method is characterized by comprising the following steps: octamethylcy-clotetrasiloxane and amino silane coupling agents with different structures are used as raw materials; with a bulk polymerization method, under the analysis of an alkali catalyst, firstly, an amino organic polysiloxane softener with high ammonia value is generated through ring-opening polymerization; and secondly, on the basis of the amino organic polysiloxane softener, amidogen is subjected to etherifying modification, thereby synthesizing the hydrophilic polyether modified amino-polysiloxane softener with good hand feeling and hydrophilic property. The prepared softener keeps the hydrophilic property and simultaneously improves the softness of hydrophilic silicon oil so that the hand feeling of textile can reach the hand feeling of the prior linearity amino silicon oil after the textile is treated by the softener and the treated textile can keep the hydrophilic property permanently.

The invention discloses a method for preparing polyester-polyester blocked copolyester, which comprises the following steps: (1) synthesizing an aromatic polyester hard segment to obtain a prepolymer P1 with a number-average molecular weight in the range of 500-10,000g/mol; (2) synthesizing an aliphatic polyester soft segment to obtain a prepolymer P2, wherein the prepolymer P2 can also be obtained by ring-opening polymerization of caprolactone monomer, and the number-average molecular weight of the prepolymer P2 is in the range of 500-10,000g/mol; (3) carrying out polycondensation reaction of the aromatic polyester oligomer and the aliphatic polyester oligomer: mixing the esterified product P1 and the esterified product P2, adding antioxidant, catalyst, passsivator and chain expander, allowing reaction at 220-260 DEG C to obtain a polyester-polyester block polyester elastomer. The catalysts used in the steps (1) and (2) are selected from titanium-containing organic substances. The method disclosed by the invention has the following advantages: (1) because the aliphatic polyester soft segment is introduced, the product has both the mechanical properties of the rigid aromatic polyester hard segment and the flexibility of the soft segment; and (2) because a number of assistants are added, the good chain expansion effect is achieved, and the reaction conditions are controlled.

A norbornene ring-opened polymer hydrogenated product having a syndiotactic structure and a process for producing the same are disclosed. The ring-opened polymer hydrogenated product contains a repeating unit originating from a polycyclic norbornene monomer with three or more rings in the polymer repeating units, having a weight average molecular weight of 500 to 1,000,000, and having a racemo diad proportion of 51% or more. The process comprises a step of polymerizing a polycyclic norbornene monomer having three or more rings by solution polymerization using a group 6 transition metal compound with a hydroxyl group-containing aryloxy group or the like bonded thereto as a polymerization catalyst to obtain a ring-opened polymer and a step of hydrogenating double bonds in the main chain of the ring-opened polymer.

The invention provides a macromolecule bonding adriamycin medicine, a nanometer capsule and a preparation method thereof. The bonding medicine is bonded by a block copolymer of poly ethylene glycol-polylactic acid and adriamycin. Firstly, the block copolymer of poly ethylene glycol-polylactic acid is acquired by ring-opening polymerization of aliphatic cyclic esters with poly ethylene glycol, solvent and catalyst being in existence; then a carboxyl end group is transformed by a hydroxyl-terminated; and then with a condensing agent being in existence, the carboxyl end group carries out amidation reaction with the adriamycin; thus acquiring the macromolecule adriamycin bonding medicine. The bonding medicine has amphiphilic property, thus being able to self assembly to prepare the nanometer capsule with a core-shell structure in the water solution. The adriamycin is wrapped inside the capsule to play a role of isolation and protection, which overcomes the deficiencies of short circulation time in vivo, large dosage and severe allergic reaction existing in the current adriamycin preparation. In addition, the nanometer particles are expected to congregate in the blood circulation through the so-called 'enhanced infiltration and retention effect', so as to improve the targeting action of the adriamycin on the tumor location.

The object of the present invention is to provide a metal catalyst which allows the production of a ring-opened polymer available from a heterocyclic compound, having primary terminal heteroatomic groups (terminal hydroxyl groups, in particular) in a ratio exceeding 75%. The above object can be attained by using a metal catalyst comprising a ligand and a metal atom for ring-opening polymerization of heterocyclic compounds in which, of all maximum angles (D) meeting the following definition, the smallest maximum angle (Dm) is not larger than 60 degrees; The maximum angle (D) is the largest angle between an imaginary line (X) and an imaginary line (Y) of all the angles which can be assumed in a metal catalyst comprising a ligand and a metal atom, said imaginary line (X) means a line perpendicular to an imaginary plane (P) including the respective centers of 3 coordinating atoms among those directly coordinating the metal atom (M) and not substitutable by a reaction substrate (S) and passing through the center of the metal atom, said imaginary line (Y) means a line linking the center of a non-coordinating atom in the ligand and the center of the metal atom, and said maximum angle (D) exists in a number equal to the number of non-coordinating atoms, that is, the number of imaginary lines (Y).

The present invention provides a method for producing a thermoplastic polyurethane elastomer having excellent heat resistance and mechanical properties, and capable of obtaining one having a low hardness without using a plasticizer. A method for producing a polyurethane elastomer, which comprises reacting a polyol compound and a polyisocyanate compound, characterized by using, as all or part of the above polyol compound, a polyester ether polyol (A) obtainable by ring-opening polymerization of a mixture of an alkylene oxide and a lactone monomer with an initiator.

The invention relates to a polylactic acid toughening modifier in the technical field of high polymer material and a preparation method thereof. Lactide ring-opening polymerization is initiated on the terminal hydroxyl of poly (butylene succinate), and purification is carried out, thus obtaining the polylactic acid toughening modifier, the chemical structural formula is as follows. The modifier of the invention prepared by adopting degradable material can solve transport phenomenon and diosmose in the prior art.

A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl ester group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl ester group. Using a suitable nucleophile, the pendant pentafluorophenyl ester group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.

The present invention relates to crosslinked polymers, synthesized through ring-opening polymerization of ethylenically unsaturated epoxides, in combination with α-hydroxy acids using a hydrophilic macroinitiator, such as poly(ethylene glycol), to form substituted copolymers having ethylenically unsaturated functionality randomly distributed along the polyester polymer backbone. That copolymer is subsequently crosslinked to form a hydrogel network. More particularly, the present invention relates to the synthesis of biodegradable poly(α-hydroxy acid-co-glycidyl methacrylate)-block-poly(ethylene glycol)-block-poly(α-hydroxy acid-co-glycidyl methacrylate) copolymers, which are subsequently crosslinked to form hydrogel networks. The invention also relates to the use of these hydrogel networks in various applications, in particular, for the controlled release of drugs and proteins.

The invention provides a paclitaxol predrug of biodegradable polymer and its synthesis method, which is bond from polyoxyalkylene-aliphatic polyester blocked copolymer and paclitaxol, the synthesizing process comprises, carrying out ring-opening polymerization of aliphatic cyclic esters at the presence of polyethylene glycol (PEG), solvent and catalyst, obtaining polyethylene glycol - aliphatic polyester blocked copolymer, then converting its end hydroxyl into end carboxyl, reacting with paclitaxol for esterification at the presence of condensing agent, the obtained paclitaxol predrug has amphiphilic, thus can be prepared into water based preparation.

The disclosed is a biodegradable copolymer, an amphiphilic diblock copolymer, composed of a hydrophilic segment and a hydrophobic segment. The hydrophilic segment is an endcapped PEG or derivatives thereof. The hydrophilic segment is a random polymer polymerized of lactone or cyclic C₃-C₆ molecule and lactic acid/glycolic acid. There is no coupling agent between the hydrophilic and hydrophobic segments, and the biodegradable copolymer is formed by one-pot ring-opening polymerization. The biodegradable copolymer can be dissolved in water to form a thermosensitive material having a phase transfer temperature of 25 to 50° C., thereby being applied to biological activity factor delivery, tissue engineering, cell culture and biological glue.

The invention provides a polylactic acid block polymer and a preparation method thereof. The preparation method comprises the following steps: mixing poly(adipic acid-terephthalic acid)butanediol copolyester, lactide and a first catalyst, and heating to a molten state to react, thereby obtaining the polylactic acid block polymer disclosed as Formula (I). Compared with the polymer obtained by the PLA-PBAT chain extension reaction initiated by diisocyanate in the prior art, the invention uses the molten-state poly(adipic acid-terephthalic acid)butanediol copolyester as the reactant to directly initiate the ring-opening polymerization of lactide, and the polymerization method is mass polymerization without adding the chain extender diisocyanate or any organic solvent, thereby avoiding jeopardizing the human body and environment; the raw materials can be mixed and heated to react to obtain the polylactic acid block polymer, so that the preparation method is simpler and lowers the preparation cost; and the polylactic acid block polymer provided by the invention has definite structure and narrow molecular weight distribution.