52 results about "Tumor location" patented technology

A system and a method of performing a frameless image-guided biopsy uses imaging, a six-dimensional robotic couch system, a laser guidance system, an optical distance indicator, and a needle control apparatus. A planning CT scan is made of the patient with stereotactic fiduciary markers to localize and produce digitally reconstructed radiographs. Two stereoscopic images are generated using an imaging device to visualize and identify a target tumor. The images are fused with the digitally reconstructed radiographs of the planning CT scan to process tumor location. The tumor location data are communicated to the movable robotic couch to position the target tumor of the patient at a known isocenter location. A biopsy needle is guided with a laser alignment mechanism towards the isocenter at the determined depth using a needle positioning apparatus and an Optical Distance Indicator, and a biopsy sample of the target tumor is obtained.

The invention provides a macromolecule bonding adriamycin medicine, a nanometer capsule and a preparation method thereof. The bonding medicine is bonded by a block copolymer of poly ethylene glycol-polylactic acid and adriamycin. Firstly, the block copolymer of poly ethylene glycol-polylactic acid is acquired by ring-opening polymerization of aliphatic cyclic esters with poly ethylene glycol, solvent and catalyst being in existence; then a carboxyl end group is transformed by a hydroxyl-terminated; and then with a condensing agent being in existence, the carboxyl end group carries out amidation reaction with the adriamycin; thus acquiring the macromolecule adriamycin bonding medicine. The bonding medicine has amphiphilic property, thus being able to self assembly to prepare the nanometer capsule with a core-shell structure in the water solution. The adriamycin is wrapped inside the capsule to play a role of isolation and protection, which overcomes the deficiencies of short circulation time in vivo, large dosage and severe allergic reaction existing in the current adriamycin preparation. In addition, the nanometer particles are expected to congregate in the blood circulation through the so-called 'enhanced infiltration and retention effect', so as to improve the targeting action of the adriamycin on the tumor location.

A steerable sonohysterographic injection catheter for identifying sentinel lymph nodes in uterine cancer patients includes a tubular shaft housing a needle extendible therefrom. The needle is preferably sized for intrauterine insertion and configured to deliver a fluid such as a contrast media to a tumor location. The catheter preferably includes a sealing device such as a selectively inflatable balloon disposed at a position along the outside of the catheter. The sealing device is configured for placement at an opening of a patient's cervix to prevent the leaking of the contrast media out of the uterus through the cervix. The distal end of the catheter is steerable so as to allow the tip of the needle to be positioned substantially near the tumor location.

The invention provides a nanogel with hydrophilic and hydrophobic reversal, charge reversal and intracellular redox responsiveness on the basis of pH regulation. The nanogel is prepared by cross-linking of thermo-sensitive monomer with controllable radical polymerization, amphoteric ionic monomer and amido-containing pH sensitive monomer through a disulfide-bond-containing cross-linking agent. The invention further provides a nanogel drug carrier system with smart response to tumor microenvironment and its preparation method. On the condition of blood pH 7.4, the nanogel is in a hydrophilic swelling state that is favorable for avoiding being phagocytosed by the reticuloendothelial system (RES) and accordingly, the nanogel has blood long circulation capacity; on the condition of tumor tissue subacidity, the state of the nanogel is reversed into a hydrophobic shrinking state that is favorable for the nanogel to realize effective concentration, depth penetration and be absorbed effectively by tumor cells on the tumor location. Besides, in the intracellular lysosome environment, negative charge of the nanogel is reversed into positive charge, which is favorable for the nanogel to escape from the lysosome; and then the nanogel releases drugs responsively in cytoplasm high-GSH environment, thereby achieving a good tumor inhibition effect.

A system and a method of performing a frameless image-guided biopsy uses imaging, a six-dimensional robotic couch system, a laser guidance system, an optical distance indicator, and a needle control apparatus. A planning CT scan is made of the patient with stereotactic fiduciary markers to localize and produce digitally reconstructed radiographs. Two stereoscopic images are generated using an imaging device to visualize and identify a target tumor. The images are fused with the digitally reconstructed radiographs of the planning CT scan to process tumor location. The tumor location data are communicated to the movable robotic couch to position the target tumor of the patient at a known isocenter location. A biopsy needle is guided with a laser alignment mechanism towards the isocenter at the determined depth using a needle positioning apparatus and an Optical Distance Indicator, and a biopsy sample of the target tumor is obtained.

The invention discloses a liver tumor automatic segmentation positioning method and system and a storage medium, The method comprises: performing window width window processing on the liver CT image to obtain the first input data of the highlighted CT liver part; inputting the first input data into the U-Net liver semantic segmentation model to obtain the liver semantic segmentation result; filtering the segmentation result to obtain the second input data; reconstructing the second input data to obtain the third input data; inputting the third input data into the tumor location detection modelto obtain the tumor location information; and acquiring the tumor location information according to the tumor location information; filtering the second input data to obtain the fourth input data; inputting the fourth input data into the U-Net tumor semantic segmentation model to obtain the tumor semantic segmentation result. The invention can quickly obtain the result of tumor semantic segmentation, reduce the time cost, improve the work efficiency, and improve the accuracy of the tumor detection, and can be widely applied to the field of image processing technology.

The invention relates to a preparation method Fe3O4 nanoparticles with a cluster structure. The preparation method comprises steps as follows: preparation of extra small Fe3O4 nanoparticles, preparation of an activated extra small Fe3O4 nanoparticle solution, and preparation of the Fe3O4 nanoparticles with the cluster structure. The preparation method is simple, the prepared Fe3O4 / Cystamine nanoparticles have good stability and biocompatibility, are sensitive to reducing conditions, can realize T1-T2 dual-mode MR imaging effect of a tumor location in an animal body, can be effectively taken asan MR imaging contrast medium and have industrialized and commercialized application prospect.

The invention discloses an integrated microfluidic chip and a three-dimensional tumor location, construction and recycling method. The disclosed chip is composed of a sample flow layer and a pneumatic control layer; the sample flow layer is provided with an inlet, micro-cavities, outlets and a micro pipeline network, and the pneumatic control layer is provided with a gas inlet, pneumatic control structures and an end-closed micro pipeline network. The pneumatic control structures are connected with the gas inlet through the end-closed micro pipeline network. The height of the pneumatic control structures is greater than that of the end-closed micro pipeline network. Tumor cell accurate locating capture, three-dimensional tumor forming and online analysis and recycling operations can be continuously completed in the single microfluidic chip. The operations have extremely strong time and space control and flexibility, and are convenient for multidisciplinary research scholars to master; and the chip has the characteristics of simple and fast operations, low sample consumption, accurate cell location, high efficiency, high throughput and the like, and is suitable for construction and analysis operations on various three-dimensional tumors.

Systems, methods, and apparatuses are provided for targeting diseased tissue with a radiation beam. Functional models can be used to accurately obtain a location of specific tissue using sensors at identifiable locations of the patient's body. Using the relative distances between the identifiable sensor locations can allow a patient to be in various positions. The functional models can be prepared using accurate pre-treatment scans, which can be taken at various body positions (e.g., rotations and / or translations). The trajectory of the beam can be measured efficiently and accurately using beam sensors attached to a beam assembly, where a model maps the beam sensor locations to a trajectory of the beam. Further, a motion model can use measurements made during treatment to obtain a time-dependent functions of the movement of the specific tissue, the change of an optimal beam trajectory over time, or the change in input commands to a beam positioner.

The invention belongs to the fields of molecular biology and immunology, and relates to chimeric chemokines receptors capable of making T cells tend to tumor locations. Specifically, the chimeric chemokines receptors are formed in a manner that a peptide fragment of a generated factor secreted by efficiently-combined tumor cells or tumor stromal cells is connected with a transmembrane region originated from a high-affinity receptor and a signal domain peptide fragment capable of making the T cells efficiently migrated through hinge structures. A membrane outer peptide fragment receives a corresponding factor signal and transfers the signal into cells, and a related path for promoting T cell chemotaxis is started through an intracellular region of the signal domain peptide fragment capable of promoting the migration of the T cells, so that the T cells modified by the chimeric chemokines receptors have a characteristic of migrating to the corresponding factor high concentration direction, and a normal tumor killing activity is not weaken, so as to ensure the tumor adoptive cell therapy effector T cells can efficiently reach the tumor nidus locations, and play a role in treatment.

The invention provides an amphiphilic polymer which has the structure shown in the formula (I), and the structure comprises a hydrophilic chain section and a hydrophobic chain section. An even and stable nano-micelle can be formed in the water solution and can be used for conveying hydrophobic medicines, meanwhile, the structure comprises a Schiff base structure, therefore, the amphiphilic polymer has the pH responsiveness, the amphiphilic polymer serving as a medicine carrier can have the intelligent responsiveness to the acid environment of the tumor locations, and the amphiphilic polymer has good application prospects in carrier pharmacology field. R is selected from .

The invention discloses an apigenin-carrying hyaluronic acid targeted nano assembly and a preparation method thereof. The system is composed of hydrophilic polysaccharide sodium hyaluronate and a hydrophobic drug namely apigenin. During preparation, firstly, sodium hyaluronate and apigenin powder are fully ground in a grinding bowl; then, the mixed powder is taken to mix with distilled water, and a primary nano suspension is obtained by stirring; and finally, ultrasonic treatment is performed with an ultrasonic cell crusher to obtain the apigenin-carrying hyaluronic acid targeted nano assembly. The drug carrier system disclosed by the invention significantly improves the dissolution rate of a drug and has good physical stability. The other outstanding advantage of the drug carrier system is that the particle size is small, the average particle size is less than 200nm, and passive targeting can be realized by virtue of an EPR (electron paramagnetic resonance) effect of a tumor location. Meanwhile, hyaluronic acid is taken as a carrier, so that the apigenin-carrying hyaluronic acid targeted nano assembly can realize active targeting, reduce toxic and side effects, and improve the treatment efficiency of an antitumor drug.

A system and methods for generating 3D images (24) from 2D bioluminescent images (22) and visualizing tumor locations are provided. A plurality of 2D bioluminescent images of a subject are acquired during a complete revolution of an imaging system about a subject, using any suitable bioluminescent imaging system. After imaging, the 2D images are registered (20) according to the rotation axis to align each image and to compensate for differences between adjacent images. After registration (20), corresponding features are identified between consecutive sets of 2D image (22). For each corresponding feature identified in each set of 2D images an orthographic projection model (24) is applied, such that rays are projected through each point in the feature. The intersection point of the rays are plotted in a 3D image of a tumor is generated. The 3D image can be registered with a reference image of the subject, so that the shape and location of the tumor can be precisely visualized with respect to the subject.

The invention is applicable to the technical field of operation training devices, and provides a tumor respiratory movement simulation platform and a tumor position estimation method, the tumor respiratory movement simulation platform is used for percutaneous puncture operation, and comprises a human abdomen phantom which is of an inner hollow structure and is covered with humanoid skin, and positioning mark points are arranged on the humanoid skin; the air bag is fixedly arranged in the human abdomen phantom and can be circularly inflated and deflated, and the air bag is always kept in contact with the humanoid skin in the inflating and deflating process; the guide rail is arranged on the human abdomen body membrane and is opposite to the humanoid skin; the displacement plate is connectedto the guide rail in a sliding mode, one side of the air bag abuts against the displacement plate, and the displacement plate reciprocates on the guide rail along with inflation and deflation of theair bag; and the puncture simulation body is fixedly arranged on the displacement plate, and a puncture target point is arranged in the puncture simulation body. According to the invention, a puncturescene closer to clinic is provided for doctors.

The invention belongs to the field of pharmaceutical chemistry, relating to a folic acid-polyethyleneglycol composite which can be combined with imageology nuclide for tumor diagnosis, wherein the folic acid composite folic acid, the polyethyleneglycol, functional oligomerized polylysine and a plurality of DTPA are connected in a covalent bond mode. After applying the folic acid composite to animal nuclear magnetic resonance or radioactive video picture diagnosis, experiment results show that the type of the composite is lead to lymphatic system without transmitting blood capillaries at tissue spaces, is dynamically concentrated and eliminated at lymph glands, combines with high-expressive tumor cells of folate receptors in a competitiveness mode, and presents excellent lymph guiding property and accumulative property of tumor locations. The invention can be effectively used for target diagnosis of tumors and metastatic tumors of the lymphatic system, and has high targeting property and high resolution of the tumor and lymphoma diagnosis.

A system and methods for generating 3D images from 2D bioluminescent images and visualizing tumor locations are provided. A plurality of 2D bioluminescent images of a subject are acquired using any suitable bioluminescent imaging system. The 2D images are registered to align each image and to compensate for differences between adjacent images. After registration, corresponding features are identified between consecutive sets of 2D images. For each corresponding feature identified in each set of 2D images, an orthographic projection model is applied, such that rays are projected through each point in the feature. The intersection points of the rays are plotted in a 3D image space. All of the 2D images are processed in the same manner, such that a resulting 3D image of a tumor is generated.

A method for fiducial-less real-time motion tracking of abdominal tumors based on the correlation between the patient's breathing pattern and the diaphragm / lung border during treatment delivery. This invention utilizes an edge detection technique to delineate the diaphragm / lung border on radiographic images in order to calculate or determine tumor locations in the abdomen. The position of the diaphragm / lung border is synchronized with the breathing pattern obtained from continuous optical monitoring of a patient's respiratory cycle. The real-time optical breathing pattern obtained from monitoring is used to determine or calculate the position of the diaphragm / lung border during treatment delivery. The position of the diaphragm / lung border is then used to determine the tumor location in real-time. The target tumor coordinates generated through this process are used by the treatment delivery system to adjust the radiation beam geometry of the treatment delivery system to follow the tumor in real-time and accurately deliver radiation dose.

The invention belongs to the field of bio-pharmaceuticals and particularly relates to expression, purification and self-assembly of TRAIL variant proteins. A recombinant protein is expressed by plasmids comprising the TRAIL fusion proteins in escherichia coli, and the recombinant protein with high activity is produced. The recombinant proteins adopt a centrifugal mode for simple and rapid purification. The purified proteins are self-assembled into particles being 200 nanometers under the physiological conditions. After intravenous injection to a tumor transplantation mouse, the recombinant protein is effectively gathered in the tumor location of the mouse. The recombinant protein is injected into the tumor transplantation mouse in an intraperitoneal injection mode, and tumor growth is effectively suppressed. The recombinant protein subjected to simple process purification is used for oncotherapy.

The invention discloses a multi-mode guided adaptive radiotherapy system. The system mainly comprises two kilovolt-level X-ray imaging systems, an infrared positioning and tracking system and a megavolt-level X-ray imaging system. According to the multi-mode guided adaptive radiotherapy system of the invention, different modes of image and dose signals are integrated, so that the two externally arranged X-ray imaging systems, the infrared positioning and tracking system and the megavolt-level X-ray imaging system which is mounted on an accelerator can be integrated in the multi-mode guided adaptive radiotherapy system; tumor location real-time tracking correction and irradiation dose verification can be simultaneously performed during a treatment process; dynamic adjustment can be realized; the problem of the position and shape change of a target area in radiotherapy can be solved in real time; a treatment plan is update according to the latest anatomical structure of a patient beforeeach round of treatment; the position of the patient and errors caused by target area movement collection can be timely adjusted during the radiotherapy, so that current and subsequent treatment can be guided; an accurate prescription dose can be allocated to the tumor target area; and therefore, adaptive radiotherapy can be realized.

The invention discloses a PET (positron emission computed tomography)-fluorescence dual-mode intraoperative navigation imaging system and an imaging method implemented by the same. The imaging method includes forming three-dimensional surface contour images of imaging samples by the aid of a spatial registration device; acquiring three-dimensional PET images of internal structures of the imaging samples by the aid of a PET imaging device; carrying out image registration and fusion on the three-dimensional surface contour images and the three-dimensional PET images to obtain three-dimensional fused images of imaging targets; acquiring two-dimensional fluorescence images of the imaging samples in real time by the aid of a fluorescence imaging device; projecting the three-dimensional fused images towards the two-dimensional fluorescence images along the normal axis of an imaging surface of the fluorescence imaging device and displaying depth information of the imaging targets on the two-dimensional fluorescence images. The three-dimensional fused images of the imaging targets comprise surface contours and internal structures. The PET-fluorescence dual-mode intraoperative navigation imaging system and the imaging method have the advantages that the PET-fluorescence dual-mode intraoperative navigation imaging system and the imaging method can be applied to tumor operation, the three-dimensional PET images and the two-dimensional fluorescence images are fused in computers, two imaging modes are complementary to each other, accordingly, tumor at optional depths can be accurately positioned, accurate tumor location information can be provided for patients, and tumor R0-resection can be implemented.

The invention discloses a sub-pixel-level real-time dynamic tumor image localization and matching method, belongs to the field of medical image processing, and aims to quickly and accurately match andlocate the tumor tissue in the real-time dynamic image. The method comprises the following steps: pre-processing acquired tumor images, wherein the tumor images include an original image and a imageto be matched; scanning the pre-processed tumor images, and acquiring the edge coordinates of the region where a tumor is located in the tumor images, thereby performing integer pixel level matching of the original image and the image to be matched, and calculating the integer pixel level coordinates of a tumor center point on the image to be matched; and using a gradient algorithm to perform sub-pixel-level matching on the original image and the image to be matched, and calculating the sub-pixel-level coordinates of the tumor center point on the image to be matched. This method enables precise matching and localization of the tumor location.

The invention provides a doxorubicin bonding medicine. The doxorubicin bonding medicine comprises a first repeating unit with a structure shown in a formula (I), a second repeating unit with a structure shown in a formula (II), a third repeating unit with a structure shown in a formula (III) and a fourth repeating unit with a structure shown in a formula (IV). The invention further provides a method for preparing the doxorubicin bonding medicine. According to the doxorubicin bonding medicine, glucan, carboxylation doxorubicin derivatives, lactobionic acid and folic acid are taken as raw materials to be subjected to condensation reaction, so that the doxorubicin bonding medicine is obtained, wherein the lactobionic acid and the folic acid have active targeting functions. The doxorubicin bonding medicine provided by the invention can be concentrated on tumor locations through the increased permeation and retention effects and the active targeting functions; and mover, the polymer doxorubicin bonding medicine provided by the invention has pH responsiveness, doxorubicin which is bonded on the polymer medicine through amido bonds can be quickly released in tumor tissues or tumor cells under the pH condition, and thus, the medicine effectiveness is increased.

The invention discloses an imaging method of tumor targeting based on enhancement effect of zinc ion effects. When the imaging method of the tumor targeting based on the enhancement effect of the zinc ion signals is applied at the cellular level, a zinc saline solution is manufactured firstly. Then the saline solution is arranged into a cell incubator together with cancer cells or cancer tissues for incubation. After high resolution fluorescence microscopic imaging and Raman imaging are carried out, qualitative and quantitative analysis is performed on the structure or chemical constituents of the cancer cells or the cancer tissues through the signal data of a fluorescence spectrum and a Raman spectrum. When the imaging method of the tumor targeting based on the enhancement effect of the zinc ion signals is applied at the animal model level, a tumor animal model is constructed and the zinc saline solution is manufactured, after part of the tumor location of an experimental animal is injected with the zinc saline solution, a confocal fluorescence microscope, an ultrasonic imaging device, a fluorescence imaging device, a Raman spectrometer or a Raman microscope are used for monitoring the signal information of the tumor cells or the cancer tissues and processing and analyzing the signal information. Due to the fact that the zinc ions are adopted as the imaging signal enhancer, the imaging method of the tumor targeting based on the enhancement effect of the zinc ion signals has small toxicity on a living body, and has tumor targeting capability.

Systems, methods, and apparatuses are provided for targeting diseased tissue with a radiation beam. Functional models can be used to accurately obtain a location of specific tissue using sensors at identifiable locations of the patient's body. Using the relative distances between the identifiable sensor locations can allow a patient to be in various positions. The functional models can be prepared using accurate pre-treatment scans, which can be taken at various body positions (e.g., rotations and / or translations). The trajectory of the beam can be measured efficiently and accurately using beam sensors attached to a beam assembly, where a model maps the beam sensor locations to a trajectory of the beam. Further, a motion model can use measurements made during treatment to obtain a time-dependent functions of the movement of the specific tissue, the change of an optimal beam trajectory over time, or the change in input commands to a beam positioner.

The invention provides a cobalt-zirconium gold marker implant, and relates to the technical field of implanted medical apparatuses. The cobalt-zirconium gold marker implant comprises a gold marker main body, wherein the gold marker main body is made from metallic cobalt and zirconium; the gold marker main body is represented in a capsule-shaped or drum-shaped form, and lines, by which friction is increased, are arranged on the outer surface of the gold marker main body; and a drug layer is additionally arranged on the outer surface of the gold marker main body. Before a tumor treatment operation, the cobalt-zirconium gold marker implant is implanted into a focus or surrounding tissues thereof; with the design of the lines, friction force between the cobalt-zirconium gold marker implant and human tissues is increased, and since the metallic cobalt and zirconium can shelter X light, the cobalt-zirconium gold marker implant is helpful for medical personnel to accurately track tumor locations in a process of implementing radiotherapy, so that purposes of rapid location and precise treatment are achieved; meanwhile, high-purity drug molecules, which are released from the drug layer, are directly absorbed by the focus so as to take an adjuvant therapy effect to inhibit or kill tumor cells and to improve operating and therapeutic effects. On this basis, the invention also provides a gold marker implantation apparatus.

The invention relates to the field of medical high molecular materials, and discloses a reduction-response self-depolymerization graft polymer based on a polysaccharide as well as a preparation methodand application thereof. The structure of the reduction-response self-depolymerization polymer provided by the invention is a polysaccharide-graft(disulfide bond)-self-depolymerization polymer; the polymer can be triggered in a state of a low-concentration reducer to be degraded into a small molecule; the release and metabolism, from a body, of a medicine are more easily promoted. In the preparation method, the polysaccharide and a self-depolymerization polymer are coupled through a copper-free click reaction; the reaction is efficient and nontoxic. In addition, the reduction-response self-depolymerization graft polymer based on the polysaccharide can be used for forming a micelle with a core-shell structure in a self-assembly manner in water; the micelle can be used for loading a hydrophobic chemotherapeutic drug; due to the favorable biocompatibility and stealth performance of the polysaccharide, the effective aggregation at a tumor location is achieved through an EPR (Enhanced Permeability and Retention) effect; afterwards, the self-depolymerization graft polymer is triggered by a reducing environment of the tumor part to carry out self-depolymerization; the medicine is quicklyreleased, and the curative effect is exerted.

The invention discloses a photoelectric microneedle, as well as a preparation method and application thereof. The invention first provides the method for preparing the photoelectric microneedle whichis prepared from nano-particles with a photoelectric effect and a biodegradable raw material in a mass ratio of (3-8):5. The method has simple operation, low cost and good repeatability. The photoelectric microneedle prepared by the method has sufficient puncture performance, can puncture the stratum corneum and reach the corium layer, can be used for delivering the nano-particles with the photoelectric effect to tumor location, generating a photoelectric signal under lighting and quickly and efficiently killing cancer cells on the body surface, does not hurt skin or leave a scar. The photoelectric microneedle can be biodegraded in the body, and the degraded product does not have toxic or side effect, so that the photoelectric microneedle has excellent application prospect and wide development space in preparation of medicines for treating body surface cancers.

The invention discloses an integrated microfluidic chip and a three-dimensional tumor location, construction and recycling method. The disclosed chip is composed of a sample flow layer and a pneumatic control layer; the sample flow layer is provided with an inlet, micro-cavities, outlets and a micro pipeline network, and the pneumatic control layer is provided with a gas inlet, pneumatic control structures and an end-closed micro pipeline network. The pneumatic control structures are connected with the gas inlet through the end-closed micro pipeline network. The height of the pneumatic control structures is greater than that of the end-closed micro pipeline network. Tumor cell accurate locating capture, three-dimensional tumor forming and online analysis and recycling operations can be continuously completed in the single microfluidic chip. The operations have extremely strong time and space control and flexibility, and are convenient for multidisciplinary research scholars to master; and the chip has the characteristics of simple and fast operations, low sample consumption, accurate cell location, high efficiency, high throughput and the like, and is suitable for construction and analysis operations on various three-dimensional tumors.

Disclosed herein is a method of acoustically delivering a therapeutic composition to a subject pre-diagnosed with a tumor. The method comprises the steps of: parenterally administering the composition from a site remote from a tumor location; and exposing the parenterally administering site to ultrasound waves to target the delivery of the composition. The therapeutic composition comprises an effective amount of a polypeptide or a plasmid nucleic acid encoding the polypeptide, the polypeptide or the nucleic acid is suspended in a dispersed medium; and an effective amount of an microbubble contrast agent; wherein the polypeptide is an angiogenesis inhibitor, and the therapeutic composition is capable of reducing the size of the tumor without the risk of inducing viral vector-induced immunogenicity in the subject.