159results about How to "Adverse effect" patented technology

Methods are disclosed which utilize metabolites of bupropion for treating disorders ameliorated by inhibition of neuronal monoamine reuptake. Such disorders include, cerebral function disorders, cigarette smoking, and incontinence.

The present invention embodiments pertain to conducting fantasy sports or other competitions, where users select or draft an entirely new team of professional players each week (or at other suitable time interval). The competition types (including playoffs) include fee based and free. Each fee based competition has a pre-determined entry fee, and prizes are awarded to the winner of that competition each week. The free competitions similarly include weekly prizes and further provide for a grand prize. Within each of the free and fee based types of competitions, users may compete in a “private” competition or a randomly composed “open” competition. Users within the free and fee based competitions may accumulate points that qualify for redemption to obtain prizes. These points are accumulated based upon the statistical performance of the drafted players for each team. The present invention embodiments further provide mechanisms for information sharing and interaction between users.

The present patent application relates to the novel nucleoside derivatives and novel intermediates, which are useful to antiviral, anti tumor and immunomodulatory activity, method of treating diseases, conditions and / or disorders modulated by viral infections with them, and processes for preparing them.

Methods and compositions for the treatment of treatment-resistant depression are described. More specifically, the invention demonstrates that intranasal administration of ketamine is effective to ameliorate the symptoms of depression in a patient who has not responded to an adequate trial of one antidepressant in the current episode and has recurrent or chronic depressive symptoms (>2 years).

An object of the present invention is to provide an encryption / decryption system and encryption / decryption equipment which suppress the adverse effect of a load on arithmetic and logic operations to be performed by a computer, whose cipher system is hard to infer, which provide great security, and which eliminate the labor of managing keys or entering a key. A security key that encrypts or decrypts data using random numbers generated by a thermal noise random number generator is detachably attached to a personal computer. When attached to the personal computer, the security key autonomously encrypts or decrypts data to be handled by the personal computer. In other words, encryption / decryption equipment employing the thermal noise random number generator is detachably attached to a computer. The encryption / decryption equipment can be used as easily as keystrokes are made, and great security can be guaranteed.

An interchangeable lens to be detachably attached to a camera body, that includes a holding unit at which a plurality of contacts is arranged, the interchangeable lens includes: a first communication contact system arranged at the holding unit; and a second communication contact system different from the first communication contact system, arranged at the holding unit at a position different from a position at which the first communication contact system is arranged. The fourth contact is arranged at a position closer to the second communication contact system than the first contact, the second contact, and the third contact are, and the seventh contact and the eighth contact are arranged at positions closer to the first communication contact system than the fifth contact and the sixth contact are.

The present invention provides a valvuloplasty catheter which has a scoring element at its distal part to score stenotic, calcified heart valves in radial direction and to make the single valve flaps / leaflets work again. In addition to this, the device could comprise an attached balloon to post-dilate the valve after the scoring procedure. To reduce a future recalcification, the scoring element and / or the balloon have a pharmacologic coating on their outer surface.

A compensating advanced feature patch panel that can include removable modular or fixed electronic components located directly on the patch panel which are separately or in combination capable of providing advanced features such as device detection and power insertion. The patch panel provides communications between an insulation displacement connector (IDC) at a PD / User end, and any standard interface type using unshielded twisted pair cables, such as an RJ45 connector at a switch end at performance levels of at least category 3, 5, 5e, 6 and / or higher (e.g. 6e or 7) and equivalent performance levels as required by compensating for the active electronics used in providing advanced features through the use of inductive, capacitive and reactive circuit elements to compensate for advanced feature electronics.

The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group represented by the general formula: or a group represented by the general formula: while the other represents an optionally substituted C1-6 alkyl group etc.; R2 represents H, a halogen atom, OH, an optionally substituted C1-6 alkyl group etc.; X represents a single bond, O or S; Y represents a single bond, a C1-6 alkylene group etc.; Z represents CO or SO2; R4 and R5 represent H, an optionally substituted C1-6 alkyl group etc.; and R3, R6 and R7 represent H, a halogen atom etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT1 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.

A system and a method of performing a frameless image-guided biopsy uses imaging, a six-dimensional robotic couch system, a laser guidance system, an optical distance indicator, and a needle control apparatus. A planning CT scan is made of the patient with stereotactic fiduciary markers to localize and produce digitally reconstructed radiographs. Two stereoscopic images are generated using an imaging device to visualize and identify a target tumor. The images are fused with the digitally reconstructed radiographs of the planning CT scan to process tumor location. The tumor location data are communicated to the movable robotic couch to position the target tumor of the patient at a known isocenter location. A biopsy needle is guided with a laser alignment mechanism towards the isocenter at the determined depth using a needle positioning apparatus and an Optical Distance Indicator, and a biopsy sample of the target tumor is obtained.

Pixels in a window, which corresponds to the position of an input pixel and has a predetermined size, are extracted from a reduced image obtained by reducing an input image to a predetermined scale. Substitute data used to substitute the value of the input pixel is generated based on the extracted pixels in the window. The difference value between the substitute data and input pixel value is calculated and is compared with a first threshold value. When the difference value is smaller than the first threshold value, the input pixel value is substituted by the substitute data. Thus, low-frequency noise reduction can be attained using a minimum required memory size while suppressing adverse effects such as a resolution drop and the like.

A compact orthodontic bracket that employs a simple method of self-ligation, is compatible with both permanent and deciduous teeth and is less expensive to manufacture than existing commercial brackets. The bracket utilizes a rotary plate that covers an arch wire slot when closed and can be pivotably opened to allow arch wire changes. Ligation may also be augmented using conventional ligatures on the paired tie wings. The simplicity of the ligating mechanism allows manufacturing of a smaller bracket. It is also less vulnerable to the clogging effects of salivary deposits than commercial self-ligating brackets currently in use.

An accent compensative speech recognition system and related methods for use with a signal processor generating one or more feature vectors based upon a voice-induced electrical signal are provided. The system includes a first-language acoustic module that determines a first-language phoneme sequence based upon one or more feature vectors, and a second-language lexicon module that determines a second-language speech segment based upon the first-language phoneme sequence. A method aspect includes the steps of generating a first-language phoneme sequence from at least one feature vector based upon a first-language phoneme model, and determining a second-language speech segment from the first-language phoneme sequence based upon a second-language lexicon model.

The present invention relates to the treatment of a wide array of diseases and physiologic conditions based on modulating the level of hydrogen sulfide (H2S) in the body by at least partially eradicating small intestinal bacterial overgrowth (SIBO) in the gut. An H2S or lactulose breath test and / or detection of H2S or thiosulfate in the blood or urine may be used as a diagnostic and / or prognostic for assessing a systemic H2S load that exceeds a mammal's natural detoxification capacity. These tests may similarly be used to monitor the effectiveness of a therapeutic intervention for SIBO and / or the diseases or physiologic conditions whose pathology is linked thereto. Because SIBO is related to hyperhomocysteinemia, diseases and physiologic conditions that relate to hyperhomocysteinemia may further be monitored and treated in connection with the methods of the present invention.

A composition containing at least one alpha glucosidase inhibitor, and a method for ameliorating the adverse effects of aging and sun damage on keratinous surfaces such as skin by treating with a composition containing at least one alpha glucosidase inhibitor; as well as regimens and kits for treating skin.

A lubricating oil composition comprising a) an oil of lubricating viscosity having a viscosity index of at least about 95; b) at least one calcium detergent; c) at least one oil soluble titanium compound; d) at least one friction modifier; and e) at least one metal dihydrocarbyldithiophosphate compound. The composition has a Noack volatility of about 15 wt. % or less, and contains from about 0.05 to about 0.6 wt. % calcium from the calcium detergent, titanium metal in an amount of at least about 10 ppm up to about 1500 ppm titanium from the titanium compound, and phosphorus from the metal dihydrocarbyldithiophosphate compound in an amount up to about 0.1 wt. %.

The present invention provides compositions and methods which involve specifically antagonizing GDF8 and Activin A. In certain embodiments, compositions are provided which comprise a GDF8-specific binding protein and an Activin A-specific binding protein. For example, the invention includes compositions comprising an anti-GDF8 antibody and an anti-Activin A antibody. In other embodiments, antigen-binding molecules are provided which comprise a GDF8-specific binding domain and an Activin A-specific binding domain. For example, the invention includes bispecific antibodies that bind GDF8 and Activin A. The compositions of the present invention are useful for the treatment of diseases and conditions characterized by reduced muscle mass or strength, as well as other conditions which are treatable by antagonizing GDF8 and / or Activin A activity.

A fully formulated lubricating oil, lubricated surface, and lubricant additive concentrates for lubricants providing reduced sludge formation. The fully formulated lubricating oil composition has therein at least one succinimide dispersant derived from a polyalkylene compound having from about 50 to about 85% vinylidene double bonds in the compound, a metal containing detergent, at least one wear reducing agent, at least one antioxidant, and a hydrocarbon soluble titanium compound as a friction modifier. The lubricating oil composition is also substantially free of molybdenum compounds.

Provided is a cleaning apparatus for cleaning an object to be treated by contacting the object to be treated with a high pressure fluid of a cleaning composition containing a cleaning component as an essential ingredient. The cleaning apparatus includes high pressure fluid supplying means for supplying the high pressure fluid of the cleaning composition, a high pressure washing vessel for removing unnecessary materials deposited on the object to be treated by contacting the object to be treated with the high pressure fluid of the cleaning composition therein, a storing vessel for storing a waste high pressure fluid of the cleaning composition carrying the unnecessary materials therein, and a sealed structure for sealably housing the high pressure fluid supplying means, the high pressure washing vessel, and the storing vessel therein. The sealed structure has first exhaust means for exhausting the gas remaining in the sealed structure therefrom.

Disclosed are systems and methods for online community management. The disclosed system allows for automatic identification and punishment of players exhibiting bad sportsmanship through a combination of automatic detection schemes and a peer reporting scheme. In addition to the sportsmanship check, the disclosed system also provides automatic checks for identifying potential cheaters and generating a potential cheaters list for review by admin staff. As a result of either classification system, players found to be either bad sports or cheaters are not allowed to participate in play with the general pool of players, but instead must play in an alternate pool. For extremely harmful conduct, players may be banned from the online community.

A fluorescence detecting apparatus includes: a light source for illuminating the surface of detection of a sample with excitation light; a CCD area image sensor for detecting fluorescence emitted from the sample; and a micromirror array device for irradiating excitation light in a 2-dimensional illumination pattern generated by an information processor based on the detected result from the CCD area image sensor. In this configuration, irradiation of weak excitation light on areas that contain large amounts of fluorescent dyes hence would emit strong fluorescence makes it possible to excite reduced amounts of fluorescence and thereby inhibit adverse effects such as blurring or spreading of light of fluorescent wavelengths around the areas as well as to prevent the high-sensitivity fluorescence detecting device from being saturated by excessive amounts of light. On the other hand, irradiation of strong excitation light on areas that contain lower amounts of fluorescent dyes hence would emit weak fluorescence makes it possible to obtain high enough amounts of fluorescence that can be detected by the fluorescence detecting device.

A compensating advanced feature patch panel that can include removable modular or fixed electronic components located directly on the patch panel which are separately or in combination capable of providing advanced features such as device detection and power insertion. The patch panel provides communications between an insulation displacement connector (IDC) at a PD / User end, and any standard interface type using unshielded twisted pair cables, such as an RJ45 connector at a switch end at performance levels of at least category 3, 5, 5e, 6 and / or higher (e.g. 6e or 7) and equivalent performance levels as required by compensating for the active electronics used in providing advanced features through the use of inductive, capacitive and reactive circuit elements to compensate for advanced feature electronics.

A recording apparatus includes a recording unit configured to record an image on a recording medium, a roller configured to convey the recording medium, a first signal generation unit configured to generate a first period signal according to a movement of the recording medium, a second signal generation unit configured to generate a second period signal according to a rotation of the roller, a correction unit configured to correct the first period signal when a period value of the first period signal is outside a predetermined range, an information generation unit configured to generate variation information of a moving speed of the recording medium based on the first period signal, and a control unit configured to control recording on the recording medium based on the variation information and the second period signal.

A method and apparatus for selectively applying image enhancement processing to parts of an image. In one embodiment, spatial processing transformations, such as sharpening for example, are reduced or bypassed for pixels having color code values within a range known to be adversely affected by the spatial processing transformations. In another embodiment, color correction processing transformations are bypassed for pixels having color code values within a neutral color range. These neutral colors may have a gray-correction transformation applied in order to better separate the neutral colors from the other colors. According to another embodiment, color code values for pixels are transformed to two or more different color spaces. If a color correction transformation will have adverse affects on a pixel in one color space, corrected data from a different color space can be utilized for the pixel.

The present invention provides a valvuloplasty catheter which has a scoring element at its distal part to score stenotic, calcified heart valves in radial direction and to make the single valve flaps / leaflets work again. In addition to this, the device could comprise an attached balloon to post-dilate the valve after the scoring procedure. To reduce a future recalcification, the scoring element and / or the balloon have a pharmacologic coating on their outer surface.

The invention concerns novel pharmaceutical compositions and methods for the treatment of allergic rhinitis. More specifically, the invention concerns the inhibition of histamines, which is one of the primary causes of allergic rhinitis in human patients. The inventive pharmaceutical compositions include a carbonyl group-containing moiety, optionally in acidic medium, that combines with histamine to block histamine activity and thus reduce undesirable physiological effects of histamine in the body.

A fully formulated lubricating oil, lubricated surface, and lubricant additive concentrates for lubricants providing improved lubricant characteristics. The lubricating oil composition has therein a dispersant mixture derived from a reaction product of polyalkylene compound, a carboxylic acylating agent, and a polyamine. The polyalkylene compound of at least one dispersant in the dispersant mixture has a number average molecular weight of at least about 1200 and at least one dispersant in the dispersant mixture contains boron such that a weight ratio of boron to nitrogen (B / N) in the dispersant mixture ranges from above about 0.25 to about 1.0.

The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group represented by the general formula: or a group represented by the general formula: while the other represents an optionally substituted C1-6 alkyl group etc.; R2 represents H, a halogen atom, OH, an optionally substituted C1-6 alkyl group etc.; X represents a single bond, O or S; Y represents an optionally substituted C1-6 alkylene group etc.; Z represents —RB, —CORC etc. in which RB represents an optionally substituted C1-6 alkyl group etc.; and RC represents an optionally substituted C1-6 alkyl group etc.; R4 represents H, an optionally substituted C1-6 alkyl group etc.; and R3, R5 and R6 represent H, a halogen atom etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT1 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, impaired glucose tolerance, impaired fasting glycemia, diabetic complications or obesity, and a disease associated with the increase of blood galactose level such as galactosemia, and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.