A biodegradable
wireless dosimetry system (100) for
in vivo verification of radiotherapy, wherein the
system (100) comprises: a biodegradable
wireless in vivo dosimeter unit (1); and an external reading unit (2) wirelessly coupled to the biodegradable
wireless in vivo dosimeter unit (1); the biodegradable wireless in vivo
dosimeter unit (1) comprises: a power receiving and rectifying unit (PWR) comprising a near-field
receiver (3) and a
rectifier (4) implemented with at least one biodegradable conductor or biodegradable compound (5), wherein the power receiving and rectifying unit (PWR) is configured to receive electromagnetic energy from the external reading unit (2) and generate a DC power supply; an energy buffer block (ENB) comprising a biodegradable electrochemical energy buffer (6) configured as a Zn-
ion hybrid micro-
supercapacitor (7), electrically coupled to the
rectifier (4) and designed to stabilize the DC power supply during intermittent wireless
coupling; a
radiation sensor block (RSB) with a
radiation transduction module (8) configured to generate a
dose-proportional
signal in response to absorbed
ionizing radiation; an optional physiological sensor block (PSB) with at least one additional physiological sensor (20); a
telemetry and control block (TCB) (40) configured to process the
dose-proportional
signal and all physiological sensor signals and to provide
wireless telemetry to the external reading unit (2); and a resorbable encapsulation block (9) enclosing the near-field
receiver (3),
rectifier (4), energy buffer (6, 7),
radiation transduction module (8), physiological auxiliary sensor (20) and
telemetry and control block (40), wherein the resorbable encapsulation block (9) is configured to maintain the integrity of the device during a predefined clinical monitoring period and is subsequently biodegraded under physiological conditions; wherein the external reading unit (2) comprises a corresponding
block diagram architecture: a
coupling and power transfer block (CPB) with a transmit / receive coil (35) configured to couple with the near-field
receiver (3) and to power the biodegradable wireless in vivo dosimeter unit (1); a
signal processing block (SPB) (36) configured to demodulate and process
telemetry data received from the telemetry and control block (40); a
memory block (38) configured to store calibration data and measured
dose information; and a
user interface block (37) configured to display at least one parameter indicating the
absorbed dose for
verification of a radiotherapy plan, wherein the blocks (PWR, ENB, RSB, PSB, TCB, CPB, SPB,
memory block (38) and
user interface block (37)) are arranged such that a
block diagram of the
system (100) is defined by these functional units and their interconnections.