96 results about "Spatially resolved" patented technology

Disclosed are approaches to data acquisition, analysis, and computational forecasting that employs quantitative MRI data to predict the response of cancer to therapy. Example protocols detail how to acquire needed images followed by registration, segmentation, quantitative perfusion and diffusion analysis, model calibration, and prediction. The response of individual cancer patients to therapy is forecast by application of a biophysical, reaction-diffusion model to these data. Application of the protocol results in coregistered MRI data from at least two scan visits that quantifies an individual tumor's size, cellularity and vascular properties. This enables a spatially resolved prediction of how a particular patient's tumor will respond to therapy. A modified therapy can be determined based on predicted response.

The invention discloses a speed measurement method based on single-frame multiple exposure, and belongs to the field of hypersonic velocity field measurement. The implementation method comprises the following steps: recording equal time interval change of molecular marking in a flow field along with movement of the flow field through single-frame multi-time exposure imaging of an image enhancement camera, and realizing continuous and rapid acquisition of speed information within a short time after single-time marking. The morphological position after the time interval is determined according to the molecular marker, and the velocity field with spatial resolution in the flow field is extracted by mapping the marker before and after displacement, so that the velocity measurement precision is improved. Compared with other two-dimensional velocity field acquisition methods based on femtosecond laser molecular marker tracing velocity measurement, the method provided by the invention does not need a complex focusing lens combination, can obtain spatial positions of molecular markers at different moments only through isochronous continuous triggering exposure of a camera, thereby obtaining velocity flow field displacement information. And corresponding acceleration information can be further deduced according to the obtained velocity field. The method is especially suitable for hypersonic velocity field measurement.

Apparatuses and methods for microscopic analysis of a sample by simultaneously characterizing infrared absorption characteristics of a plurality of spatially resolved locations are described herein. These apparatuses and methods improve sampling times while collecting microscopic data regarding composition of a sample across a wide field.

The invention is suitable for the technical field of fruit quality detection, and provides a fruit internal quality detection method based on a spatial resolution spectrum, and the method comprises the following steps: collecting spatial resolution reflectivity distribution of a fruit under a plurality of wavelengths; performing non-linear fitting inversion on the spatial resolution reflectivity distribution under the plurality of wavelengths, and extracting the change relation of the reduced scattering coefficient of the internal tissues of the fruits along with the wavelengths; determining an optical characteristic parameter set of the target pulp tissue; inputting the optical characteristic parameter set into a Monte Carlo optical transmission model, simulating propagation paths and energy distribution characteristics of light with different wavelengths in the fruit, and generating optical propagation simulation data; based on comparative analysis of the light propagation simulation data and a preset quality evaluation threshold value, whether an optical abnormal area exists in the fruit or not is judged; if yes, corresponding parameters are output according to the optical characteristic deviation degree and the spatial position information of the abnormal area, and the detection precision of the internal quality of the fruits is effectively improved.

Disclosed herein is a method of obtaining at least one item of object information on at least one object by spectroscopic measurement. The method includes the following steps:i. acquiring spectroscopic data by using at least one spectrometer device;ii. acquiring, by using at least one imaging device image data of a scene within a field of view of the imaging device, the scene including at least a part of the object and at least a part of the spatial measurement range of the spectrometer device; andiii. evaluating the spectroscopic data of step i. and at least one item of image information derived from the image data of step ii., for obtaining the at least one item of object information on the at least one object.

A system and method for contact-based spatial frequency domain imaging. A medium to be imaged is contacted by a sheet comprising an array of lighting elements generating illumination light patterns illuminating the medium, and comprising an array of sensor elements measuring spatially resolved images of resulting light patterns reflected back after interaction of the illumination light patterns with the medium. The lighting elements generate illumination light patterns that are spatially modulated in light intensity along a surface of the illuminated medium according to a respective different spatial frequency. A set of spatially modulated images is determined based on the measured resulting light patterns caused by the different illumination light patterns. An image of the medium can be generated based on a combination of the spatially modulated images.

A medical imaging device configured to spatially resolve recording of multispectral video data of an examination area of a patient including a light source having multiple optical emitters with different wavelengths in the visible and NIR spectral range. The light source has an emitter whose wavelength lies in the range of ±50% of its half-width around the intersection of the blue and green filter curves or the green and red filter curves, and the exposure control and the data processing means are arranged to separately detect the affected two of the red and green or the green and blue colour signals in an exposure pattern with activation of the emitter at the intersection point and to evaluate them in the multispectral analysis with mutually different wavelengths shifted by the two affected filter curves as two supporting point wavelengths.

To improve sampling time while collecting microscopic data on the composition of a sample over a wide field of view.SOLUTION: The system includes an infrared radiation source 200 configured to illuminate a broad area of a sample with a beam of infrared radiation, a probe radiation source 222 configured to illuminate the broad area of the sample with a beam of probe radiation, a collector 212 configured to collect as collected probe radiation at least a portion of the probe radiation from each of a plurality of spatially resolved locations on the sample, and at least one camera 250 configured to detect as collected probe radiation at least a portion of the probe radiation from each of the plurality of spatially resolved locations on the sample and generate a signal indicative of infrared absorption corresponding to each of the plurality of spatially resolved locations.SELECTED DRAWING: Figure 2

The invention relates to the field of thermochemical in-situ reaction, and discloses a thermochemical reaction tank suitable for X-ray transmission in-situ analysis, which comprises a reaction generation module and a base support module, the reaction generation module comprises a reaction tube, a thermocouple, a heating resistance wire and a temperature control device. According to the invention, X-ray transmission-type analysis can be realized, and related structural characteristic changes of the material in a working process in a high-temperature and high-pressure environment can be accurately obtained; the device has a high altitude level time resolution, and has advantages for capturing an intermediate process highly dependent on time in a reaction process; the reaction tank is not limited by reaction gas selection and has a large-temperature-range heating function, so that the reaction tank can meet complex in-situ reaction experiment conditions; the method is high in characterization expansibility, can be combined with a mass spectrometer or a spatial resolution capillary sampling mass spectrometer for use, and simultaneously monitors product dynamic information in a reaction process; the device is small in size, easy to disassemble and convenient to replace to different instrument platforms for working; the device is simple in overall structure, low in manufacturing cost and beneficial to application and popularization.

The detection system of an x-ray or charged particle imaging system utilizes a high bandgap, direct conversion x-ray detection material. The signal of the x-ray / charged particle projection is recorded in a spatial light modulator, for example a liquid crystal (LC) light valve. The light valve is then read out by a polarized light optical microscope and a high speed camera. The camera is used to track the halo in the light valve to resolve its intensity and correlate it to the intensity of the incoming x-ray photons or charged particles. This allows for a spatially resolved imaging with an x-ray and / or charged particle spectrometer.

The invention relates to a sensor device (10) for thermally monitoring a room of a building (1000), comprising a sensor housing (100) which can be mounted on a ceiling or wall of a room; an infrared array sensor (200) which is attached to the side of the sensor housing facing the room and has an IR pixel array and a corresponding IR optical unit for a spatially resolved recording of thermal image pixel data; an image processing unit (300) for processing and analyzing the thermal image pixel data of the infrared array sensor (200); and a central processing unit (400) for detecting objects (40) on the image pixel plane of the thermal image pixel data processed by the image processing unit (300). The central processing unit (400) is adapted so as to track and classify detected objects (40) in order to assign associated data vectors with determined object parameters to the detected objects (40).

The application discloses a wavelength modulation surface plasmon resonance imaging sensing method, which generates multiple groups of illumination spectra by controlling a light-emitting diode, processes the spectra into p-polarized light, excites a sensing chip to generate surface plasmon resonance through prism coupling, collects corresponding reflected light intensity images by using a CMOS camera, and reconstructs surface plasmon resonance reflection spectra of each pixel on the sensing chip by using a smooth constraint reconstruction algorithm according to intensity observation values of the pixel in all images and corresponding illumination spectrum data, so as to further extract a phase signal and generate a spatially resolved phase image. The phase signal and the imaging scheme realize high-sensitivity and high-throughput sensing performance. The method realizes low-cost, high-signal-to-noise ratio and high-throughput sensing imaging.

The invention relates to a method, wherein a plurality of paper webs (4, 6, 8) are guided in a feed direction (F) through a corrugator (2), wherein a measuring device (22) is integrated in the corrugator (2), having a light source (24) and an SWIR camera system (26), wherein the SWIR camera system (26) has a field of view (28) which extends transversely to the feed direction (F), wherein one of the webs (4, 6, 8) is guided through the field of view (28) and an optical absorption measurement is repeatedly carried out in a number of spectral bands (32) using the light source (24) and the SWIR camera system (26) and measurement data (34) is thus generated, wherein a humidity (42) of the web (4, 6, 8) is calculated from the measurement data (34) in a spatially resolved manner. The invention also specifies a corresponding corrugator (2).

Techniques for operating an optical system are described. In some embodiments, light associated with a world object is received at the optical system. Virtual image light is projected onto an eyepiece of the optical system. A portion of a system field of view of the optical system to be at least partially dimmed is determined based on information detected by the optical system. A plurality of spatially resolved dimming values for the portion of the system field of view can be determined based on the detected information. The detected information can include light information, gaze information, and / or image information. A dimming device of the optical system can be adjusted according to the plurality of dimming values to reduce the intensity of light associated with the world object in the portion of the system field of view.

Apparatuses and methods for microscopic analysis of a sample by simultaneously characterizing infrared absorption characteristics of a plurality of spatially resolved locations are described herein. These apparatuses and methods improve sampling times while collecting microscopic data regarding composition of a sample across a wide field.

An image scanning microscope (100, 200) comprises a detection arrangement (112, 204) comprising a beam splitting element (122) configured to receive detection light (120), to split the detection light (120) into two parts, to direct a first part (124a) of the detection light (120) into a first beam path (126a), and to direct a second part (124b) of the detection light (120) into a second beam path (126b). The first beam path (126a) comprises a spatially resolved detector (128, 202) configured to detect a spatial distribution of the intensity of the first part (124a) of the detection light (120). The second beam path (126b) comprises a spectrally resolved detector (130) configured to detect a spectral information of the second part (124b) of the detection light (120). The image scanning microscope (100, 200) further comprises a controller (116) configured to determine a spatial distribution of at least one fluorophore species in a sample (104) based on the spatial distribution of the intensity of the first part (124a) of the detection light (120) and the spectral information of the second part (124b) of the detection light (120).

A method and system for extracting tissue optical parameters based on a long short-term memory network belongs to the technical field of the intersection of machine learning and biomedicine, and solves the problem of inaccurate extraction of tissue optical parameters caused by only utilizing part of the diffuse reflection light information and ignoring the correlation of spectral data sequence characteristics when extracting tissue optical parameters. The present invention introduces a long short-term memory network into a tissue spatial resolution diffuse reflection spectrum generation model, fully explores the correlation in spectral data points, and increases the model prediction ability while reducing model parameters. When training the tissue spatial resolution diffuse reflection spectrum generation model, the optical fiber probe structure is not considered, and all spatial resolution diffuse reflection spectra emitted from the tissue surface are included in a pre-data set, the data dimension is larger, and the model accuracy is higher after training, which effectively improves the accuracy of the tissue optical parameter and diffuse reflection spectrum mapping model, thereby improving the efficiency and accuracy of tissue optical parameter extraction.

An example method includes measuring, by at least one of a polarized light device, a spatially resolved acoustic spectroscopy device, or an eddy current device, an alpha phase data set indicative of an alpha phase of a crystalline structure of a material. The method includes receiving, by processing circuitry, the alpha phase data set, wherein the alpha phase data set comprises a plurality of pixels, wherein each pixel of the plurality of pixels includes a position, a first Euler angle, a second Euler angle, and a third Euler angle, wherein the third Euler angle is missing or erroneous. The method also includes adjusting, by the processing circuitry, the third Euler angle of a pixel of the plurality of pixels and storing, by the processing circuitry and based on adjusting the third Euler angle of the pixel reducing a total beta phase misorientation, the alpha phase data set.

The invention relates to an apparatus for multimodal analysis of sample material, for example from a tissue, which detects molecular image information from the sample material in a spatially resolved manner, for example using a MALDI time-of-flight mass analyser, records light microscopy image information from the sample material in a spatially resolved manner, and associates the two with improved accuracy to give spatially resolved co-registered overall image information.

A device for the spatially resolved measurement of a physical quantity, comprising a laser light source (1) configured to generate laser radiation in continuous wave operation, the instantaneous optical frequency of which changes over time in a plurality of first time intervals (2) and is constant in a plurality of second time intervals (3), wherein a second time interval (3) follows each first time interval (2) and a first time interval (2) follows each second time interval (3), modulation means (5) configured to generate laser pulses (6) from the laser radiation, an optical fiber (10) used for measuring the physical quantity, wherein the device is configured such that the laser pulses (6) for measuring the physical quantity are coupled into the optical fiber (10) and that Rayleigh signals generated by the laser radiation in the optical fiber (10) are coupled out of the optical fiber (10),a beam splitter (4) configured to divert a portion of the laser radiation before the laser pulses (6) are generated, an optical coupler (11) configured to mix the diverted portion of the laser radiation with the decoupled Rayleigh signals, detection means (12) configured to detect the Rayleigh signals mixed with the diverted portion of the laser radiation, and evaluation means configured to determine the physical quantity in a spatially resolved manner from the detected Rayleigh signals.

This invention discloses a laser measurement method and system for measuring temperature and particle size in non-isothermal multiphase flow, belonging to the field of optical measurement and laser diagnostics. The method includes: generating multispectral illumination light; acquiring RGB color images of the flow before and after transient non-isothermal multiphase flow; separating the two image channels to obtain a single-channel reference image and a single-channel detection image; calculating the logarithmic extinction value of each pixel at the wavelength of that channel based on its single-channel reference image and single-channel detection image; taking any channel wavelength as the reference wavelength, decoupling the temperature-related absorption coefficient and particle size-related scattering coefficient at the reference wavelength based on the logarithmic extinction value and a pre-constructed lookup table; and using a structured index to search the lookup table and invert the temperature and particle size values ​​of each pixel at the reference wavelength, generating a spatially resolved temperature and particle size distribution map at the reference wavelength. This invention improves computational efficiency and reduces system cost.

The invention discloses a spatial resolution microscopic fluorescence detection system and method, and belongs to the technical field of fluorescence detection. The microscopic fluorescence system is composed of five core modules including an exciting light module, a spatial resolution module, a white light illumination module, a signal detection module and a software control module. A light source provided by the excitation light module focuses light on the surface of a to-be-detected sample through the spatial resolution module and separates the to-be-detected sample from a detection point, energy is transmitted by taking the sample as a medium so as to excite fluorescence of the to-be-detected point, a generated signal is collected, processed and stored by the signal detection module, and the white light illumination module is an observation sample. A white light source is provided for a mobile sample and the like, and a software control module provides mechanization, automation and digitization of control for the whole system instrument, so that the spatial resolution effect of the device is more favorably displayed, the practicability and operability are improved, and experimental errors are reduced.

Method for spatially resolved localization of a defect in a component, the method comprising the steps: - Providing (S1) a salience map of a NOK image or a NOK fault class image of a component exhibiting a defect; - Apply (S2) at least one dimension reduction method to the provided salience map to generate a dimensionally reduced salience map; and - spatially resolved localization (S3) of the component defect based on the dimensionally reduced salience map.

The invention discloses a single Rydberg atom receiver multi-target direction of arrival estimation method based on spatial resolution fluorescence spectrum analysis. According to the method, a modulation pattern formed by interference of a plurality of radio frequency signals and a local oscillation field in the steam chamber is obtained through spatial resolution fluorescence imaging, traditional lumped power measurement is replaced, and therefore multi-target spatial information is completely reserved. On the basis, complex spatial modulation caused by a plurality of signals is linearized into superposition of sine waves with different spatial frequencies by utilizing a strong local oscillation condition, so that a multi-target direction-of-arrival estimation problem is converted into a classical frequency spectrum estimation problem. And finally, through spectrum analysis, extracting each spatial frequency and calculating a corresponding direction of arrival. According to the method, through the core steps of spatial resolution imaging, linear modeling and spectral analysis, the limitation that a single Rydberg atom receiver can only estimate a single target is fundamentally broken through, and simultaneous estimation of the directions of arrival of a plurality of signal sources by using a single receiver is realized.

Method for determining reflection properties of a test surface (38) of an optical element (41) that reflects EUV radiation, comprising the following steps: - Generating a measuring beam (26) using an EUV beam generation unit (31), - Positioning the test surface (38) of the optical element (41) in relation to the measuring beam (26) such that the measuring beam hits the test surface (38) at a measuring point and a reflected beam (261) is generated at the test surface (38), - Providing an imaging system (50) in the beam path of the reflected beam (261) between the test surface (38) and a two-dimensionally extended sensor surface (34) such that an image of a beam spot (60, 61) of the measuring beam (26) generated at the measuring point is produced on the sensor surface (34), - spatially resolved detection of the image of the beam spot (60, 61) using the sensor area (34). The invention further relates to a corresponding measuring system suitable for carrying out the method. By spatially resolving the beam spot, the method or the measuring system enables a significantly simplified calibration of the measuring system as well as an improvement in measurement accuracy.

In a method for producing an optical element, at least one substrate is supplied with coating material from at least one source for depositing a respective layer system on the substrate. A plurality of zones (111, 112, 121, 122) that are laterally adjacent to one another in at least one predefined direction and each have a defined layer thickness profile and a defined layer composition are formed by targeted spatially resolved selection and / or treatment of the deposited coating material and / or the substrate. These zones differ from each other in their layer thickness profiles and / or their layer compositions. The average dimension of each of the zones in the predefined direction is between 0.1 mm and 2 cm. The optical element is a mirror array with plural mirror elements. For different substrates of this mirror array, mutually different layer thickness profiles and / or layer compositions of the respectively deposited layer system are generated.

The application discloses a kind of time and space resolution GHz spin precession detection method and system, comprising: obtaining the static synchronous radiation XMCD signal of the magnetic sample to be measured and the information of ferromagnetic resonance under specific frequency;High-frequency microwave signal is extracted from the accelerator center main microwave source and is pulsed with the same frequency (with the same frequency with the synchronous radiation X-ray pulse signal), phase delay, low-frequency modulation, power gain and microwave frequency multiplication processing after inputting plane waveguide to excite sample and generate ferromagnetic resonance;At the same time, the synchronous radiation X-ray is incident on the magnetic sample through waveguide hole, and the photoluminescence signal of the magnetic sample under different phase delays of high-frequency microwave signal relative to X-ray pulse is measured, to obtain dynamic spin precession signal;Finally, change detection position and repeat, realize spatial resolution.The application designs the detection method of system module, utilizes the advantages of synchronous radiation X-ray pulse time structure and small size light spot, realizes time and space resolution GHz spin precession detection.

A 3D printing apparatus for manufacturing a workpiece has a first radiation source to carry out a non-linear absorption polymerization and a second radiation source to carry out optical coherence tomography. A first beam path is traversed by the first radiation and a second beam path is traversed by the second radiation. The first and second beam paths are formed completely independently of one another. Further, a 3D printing method for manufacturing a workpiece, another 3D printing apparatus, and methods for analyzing the quality of a raw material of a non-linear absorption polymerization; checking an orientation of a substrate to be printed by non-linear absorption polymerization; determining a spatially resolved degree of conversion of a non-linear absorption polymerization; analyzing a structural sharpness of a structure produced by non-linear absorption polymerization; and for three-dimensional reconstruction of a workpiece manufactured by non-linear absorption polymerization are disclosed.

Method for the spatially resolved introduction of an intensity pattern (5) of electromagnetic radiation by means of an optical imaging system (3) into a photosensitive substance with properties that can be changed by photon irradiation and that comprise a first, liquid and at least one second state, wherein the electromagnetic radiation (4) is guided via the optical imaging system (3) into the photosensitive substance (2) and is imaged there onto predetermined spatial coordinates in order to produce a change in the substance properties at these spatial coordinates or in the areas surrounding them, wherein the change in the properties of the photosensitive substance (2) is initiated and / or de-excited by a multi-photon process, wherein the optical imaging system (3) comprises a lens, wherein the lens is immersed in the liquid photosensitive substance (2), wherein the photosensitive substance (2) serves as an immersion medium, wherein the photosensitive substance (2) is a liquid photoresist system with a refractive index between 1.3 and 1.7.