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51 results about "Spatially resolved" patented technology

Spatially resolved metabolic alterations hold the key to defining the dependencies of metabolism that are most limiting for cancer growth and exploring metabolic targeted strategies for better cancer treatment.

Medical imaging device for spatially resolved recording of multispectral video data

A medical imaging device configured to spatially resolve recording of multispectral video data of an examination area of a patient including a light source having multiple optical emitters with different wavelengths in the visible and NIR spectral range. The light source has an emitter whose wavelength lies in the range of ±50% of its half-width around the intersection of the blue and green filter curves or the green and red filter curves, and the exposure control and the data processing means are arranged to separately detect the affected two of the red and green or the green and blue colour signals in an exposure pattern with activation of the emitter at the intersection point and to evaluate them in the multispectral analysis with mutually different wavelengths shifted by the two affected filter curves as two supporting point wavelengths.
Owner:KARL STORZ SE & CO KG

Method and apparatus for broadband optical photothermal infrared spectroscopy

To improve sampling time while collecting microscopic data on the composition of a sample over a wide field of view.SOLUTION: The system includes an infrared radiation source 200 configured to illuminate a broad area of a sample with a beam of infrared radiation, a probe radiation source 222 configured to illuminate the broad area of the sample with a beam of probe radiation, a collector 212 configured to collect as collected probe radiation at least a portion of the probe radiation from each of a plurality of spatially resolved locations on the sample, and at least one camera 250 configured to detect as collected probe radiation at least a portion of the probe radiation from each of the plurality of spatially resolved locations on the sample and generate a signal indicative of infrared absorption corresponding to each of the plurality of spatially resolved locations.SELECTED DRAWING: Figure 2
Owner:PHOTOTHERMAL SPECTROSCOPY CORP

Spectrally and spatially resolving x-ray and particle detection system

ActiveCN115668000BTomographyNon-linear opticsSpatial light modulatorLiquid crystal light valve
The detection system of an x-ray or charged particle imaging system utilizes a high bandgap, direct conversion x-ray detection material. The signal of the x-ray / charged particle projection is recorded in a spatial light modulator, for example a liquid crystal (LC) light valve. The light valve is then read out by a polarized light optical microscope and a high speed camera. The camera is used to track the halo in the light valve to resolve its intensity and correlate it to the intensity of the incoming x-ray photons or charged particles. This allows for a spatially resolved imaging with an x-ray and / or charged particle spectrometer.
Owner:CARL ZEISS GMBH

A wavelength modulated surface plasmon resonance imaging sensing method

PendingCN122631594ASurface plasmon resonance imagingPrism
The application discloses a wavelength modulation surface plasmon resonance imaging sensing method, which generates multiple groups of illumination spectra by controlling a light-emitting diode, processes the spectra into p-polarized light, excites a sensing chip to generate surface plasmon resonance through prism coupling, collects corresponding reflected light intensity images by using a CMOS camera, and reconstructs surface plasmon resonance reflection spectra of each pixel on the sensing chip by using a smooth constraint reconstruction algorithm according to intensity observation values of the pixel in all images and corresponding illumination spectrum data, so as to further extract a phase signal and generate a spatially resolved phase image. The phase signal and the imaging scheme realize high-sensitivity and high-throughput sensing performance. The method realizes low-cost, high-signal-to-noise ratio and high-throughput sensing imaging.
Owner:GUANGDONG UNIV OF TECH

Wide area optical photothermal infrared spectroscopy

Apparatuses and methods for microscopic analysis of a sample by simultaneously characterizing infrared absorption characteristics of a plurality of spatially resolved locations are described herein. These apparatuses and methods improve sampling times while collecting microscopic data regarding composition of a sample across a wide field.
Owner:PHOTOTHERMAL SPECTROSCOPY CORP

Image scanning microscope and method

An image scanning microscope (100, 200) comprises a detection arrangement (112, 204) comprising a beam splitting element (122) configured to receive detection light (120), to split the detection light (120) into two parts, to direct a first part (124a) of the detection light (120) into a first beam path (126a), and to direct a second part (124b) of the detection light (120) into a second beam path (126b). The first beam path (126a) comprises a spatially resolved detector (128, 202) configured to detect a spatial distribution of the intensity of the first part (124a) of the detection light (120). The second beam path (126b) comprises a spectrally resolved detector (130) configured to detect a spectral information of the second part (124b) of the detection light (120). The image scanning microscope (100, 200) further comprises a controller (116) configured to determine a spatial distribution of at least one fluorophore species in a sample (104) based on the spatial distribution of the intensity of the first part (124a) of the detection light (120) and the spectral information of the second part (124b) of the detection light (120).
Owner:LEICA MICROSYSTEMS CMS GMBH

Apparatus for multimodal analysis of sample material

The invention relates to an apparatus for multimodal analysis of sample material, for example from a tissue, which detects molecular image information from the sample material in a spatially resolved manner, for example using a MALDI time-of-flight mass analyser, records light microscopy image information from the sample material in a spatially resolved manner, and associates the two with improved accuracy to give spatially resolved co-registered overall image information.
Owner:BRUKER DALTONIK GMBH & CO KG

Laser measurement method and system for non-isothermal multiphase flow temperature and particle size measurement

This invention discloses a laser measurement method and system for measuring temperature and particle size in non-isothermal multiphase flow, belonging to the field of optical measurement and laser diagnostics. The method includes: generating multispectral illumination light; acquiring RGB color images of the flow before and after transient non-isothermal multiphase flow; separating the two image channels to obtain a single-channel reference image and a single-channel detection image; calculating the logarithmic extinction value of each pixel at the wavelength of that channel based on its single-channel reference image and single-channel detection image; taking any channel wavelength as the reference wavelength, decoupling the temperature-related absorption coefficient and particle size-related scattering coefficient at the reference wavelength based on the logarithmic extinction value and a pre-constructed lookup table; and using a structured index to search the lookup table and invert the temperature and particle size values ​​of each pixel at the reference wavelength, generating a spatially resolved temperature and particle size distribution map at the reference wavelength. This invention improves computational efficiency and reduces system cost.
Owner:XIDIAN UNIV

Spatial resolution microscopic fluorescence detection system and method

The invention discloses a spatial resolution microscopic fluorescence detection system and method, and belongs to the technical field of fluorescence detection. The microscopic fluorescence system is composed of five core modules including an exciting light module, a spatial resolution module, a white light illumination module, a signal detection module and a software control module. A light source provided by the excitation light module focuses light on the surface of a to-be-detected sample through the spatial resolution module and separates the to-be-detected sample from a detection point, energy is transmitted by taking the sample as a medium so as to excite fluorescence of the to-be-detected point, a generated signal is collected, processed and stored by the signal detection module, and the white light illumination module is an observation sample. A white light source is provided for a mobile sample and the like, and a software control module provides mechanization, automation and digitization of control for the whole system instrument, so that the spatial resolution effect of the device is more favorably displayed, the practicability and operability are improved, and experimental errors are reduced.
Owner:SHIHEZI UNIVERSITY

Method and device for spatially resolved localization of a defect in a component

Method for spatially resolved localization of a defect in a component, the method comprising the steps: - Providing (S1) a salience map of a NOK image or a NOK fault class image of a component exhibiting a defect; - Apply (S2) at least one dimension reduction method to the provided salience map to generate a dimensionally reduced salience map; and - spatially resolved localization (S3) of the component defect based on the dimensionally reduced salience map.
Owner:ROBERT BOSCH GMBH

Multi-target direction of arrival estimation method for single Rydberg atom receiver

PendingCN122017726ASpectral/fourier analysisDirection finders using electromagnetic wavesFrequency spectrumSpatial frequency
The invention discloses a single Rydberg atom receiver multi-target direction of arrival estimation method based on spatial resolution fluorescence spectrum analysis. According to the method, a modulation pattern formed by interference of a plurality of radio frequency signals and a local oscillation field in the steam chamber is obtained through spatial resolution fluorescence imaging, traditional lumped power measurement is replaced, and therefore multi-target spatial information is completely reserved. On the basis, complex spatial modulation caused by a plurality of signals is linearized into superposition of sine waves with different spatial frequencies by utilizing a strong local oscillation condition, so that a multi-target direction-of-arrival estimation problem is converted into a classical frequency spectrum estimation problem. And finally, through spectrum analysis, extracting each spatial frequency and calculating a corresponding direction of arrival. According to the method, through the core steps of spatial resolution imaging, linear modeling and spectral analysis, the limitation that a single Rydberg atom receiver can only estimate a single target is fundamentally broken through, and simultaneous estimation of the directions of arrival of a plurality of signal sources by using a single receiver is realized.
Owner:HUAZHONG UNIV OF SCI & TECH

Method and measuring system for determining the reflection properties of a test surface

Method for determining reflection properties of a test surface (38) of an optical element (41) that reflects EUV radiation, comprising the following steps: - Generating a measuring beam (26) using an EUV beam generation unit (31), - Positioning the test surface (38) of the optical element (41) in relation to the measuring beam (26) such that the measuring beam hits the test surface (38) at a measuring point and a reflected beam (261) is generated at the test surface (38), - Providing an imaging system (50) in the beam path of the reflected beam (261) between the test surface (38) and a two-dimensionally extended sensor surface (34) such that an image of a beam spot (60, 61) of the measuring beam (26) generated at the measuring point is produced on the sensor surface (34), - spatially resolved detection of the image of the beam spot (60, 61) using the sensor area (34). The invention further relates to a corresponding measuring system suitable for carrying out the method. By spatially resolving the beam spot, the method or the measuring system enables a significantly simplified calibration of the measuring system as well as an improvement in measurement accuracy.
Owner:CARL ZEISS SMT GMBH

Method for producing an optical element, optical element and coating arrangement

In a method for producing an optical element, at least one substrate is supplied with coating material from at least one source for depositing a respective layer system on the substrate. A plurality of zones (111, 112, 121, 122) that are laterally adjacent to one another in at least one predefined direction and each have a defined layer thickness profile and a defined layer composition are formed by targeted spatially resolved selection and / or treatment of the deposited coating material and / or the substrate. These zones differ from each other in their layer thickness profiles and / or their layer compositions. The average dimension of each of the zones in the predefined direction is between 0.1 mm and 2 cm. The optical element is a mirror array with plural mirror elements. For different substrates of this mirror array, mutually different layer thickness profiles and / or layer compositions of the respectively deposited layer system are generated.
Owner:CARL ZEISS SMT GMBH

A time and spatially resolved ghz spin precession detection method and system

The application discloses a kind of time and space resolution GHz spin precession detection method and system, comprising: obtaining the static synchronous radiation XMCD signal of the magnetic sample to be measured and the information of ferromagnetic resonance under specific frequency;High-frequency microwave signal is extracted from the accelerator center main microwave source and is pulsed with the same frequency (with the same frequency with the synchronous radiation X-ray pulse signal), phase delay, low-frequency modulation, power gain and microwave frequency multiplication processing after inputting plane waveguide to excite sample and generate ferromagnetic resonance;At the same time, the synchronous radiation X-ray is incident on the magnetic sample through waveguide hole, and the photoluminescence signal of the magnetic sample under different phase delays of high-frequency microwave signal relative to X-ray pulse is measured, to obtain dynamic spin precession signal;Finally, change detection position and repeat, realize spatial resolution.The application designs the detection method of system module, utilizes the advantages of synchronous radiation X-ray pulse time structure and small size light spot, realizes time and space resolution GHz spin precession detection.
Owner:UNIV OF SCI & TECH OF CHINA

System and method for detecting optical signals of a test object that is moved relative to a target

The invention relates to a system (100) for detecting optical signals (20) of a test object (10) that is moved relative to a target (50) in the intended test state, wherein the test object (10) has at least one light source (12) for transmitting the optical signals (20), comprising at least one optical receiving unit (30) for receiving the optical signals (20) of the at least one light source (12), wherein the optical receiving unit (30) is designed for digital high-speed data acquisition with pixels addressable in spatially resolved fashion, in particular in the order of microseconds, wherein the at least one light source (12) is oriented towards the optical receiving unit (30), wherein an intensity of the optical signals (20) is encoded in the pixels of temporally successive image recordings by the optical receiving unit (30). The invention further relates to a method of using a system (100) of this kind for detecting optical signals (20) of a test object (10) that is moved in an intended test state.
Owner:DEUTSCHES ZENTRUM FÜR LUFT UND RAUMFAHRT E V

Apparatus and method for digitizing optical signals and for spatially resolving and measuring temperature and strain by Brillouin scattering.

To provide an apparatus for spatially resolved measurement of temperature and strain via Brillouin scattering, and a method for spatially resolved measurement of temperature and strain.SOLUTION: An apparatus 10 for digitizing an optical signal comprises: an optical detector 1 configured to detect optical signals and to generate electric signals corresponding to the optical signals; an envelope curve detector 4 configured to determine the amplitudes of the electric signals generated by the optical detector 1 and to output electric signals corresponding to the amplitudes; an analog to digital converter 7 configured to digitize the electric signals output by the envelope curve detector 4 and to output corresponding data; and a variable voltage source 9 having an output unit connected or connectable to an input unit of the envelope curve detector 4, where the apparatus for digitizing the optical signal is configured to calibrate the envelope curve detector 4 with the variable voltage source 9.SELECTED DRAWING: Figure 1
Owner:ルナ イノベーションズ ジャーマニー ゲーエムベーハー

On-board satellite crop analysis apparatus and method of use thereof

The invention comprises a method for managing cropland, comprising the steps of: (1) measuring, each of a set of spatially resolved locations, level zero data with an orbiting satellite, the level zero data comprising, spectral responses in ranges of 400 to 00; 1,100 to 2,500; and 2,500 to 12,000 nm; (2) processing, on-board the orbiting satellite, the level zero data comprising a first data storage size, to yield crop condition information comprising a second data storage size of less than one percent of the first data storage size; (3) measuring, on-board the orbiting satellite, crop transpiration with the near-infrared radiation to determine drought locations of the set of spatially resolved locations; (4) receiving from the orbiting satellite to a ground based communication system the crop condition information including the drought locations; and (5) relaying at least a portion of the crop condition information to a farmer within twenty-four hours.
Owner:GEORGE THOMAS

Method and device for spatially resolved localization of defects of component

The invention relates to a method and a device for spatially resolved localization of defects of a component. The invention relates to a method for spatially resolved localization of a defect of a component, comprising the following steps: providing (S1) a saliency map of a NOK image or a NOK defect-like image of a component having a defect; applying (S2) at least one dimensionality reduction method to the provided saliency map for generating a dimensionality-reduced saliency map; and-spatially resolved localization (S3) of defects of the component on the basis of the dimensionality-reduced saliency map.
Owner:ROBERT BOSCH GMBH

Compact phase and darkfield laboratory X-ray imaging system and method

An X-ray microscopy system and method for phase contrast and dark-field imaging utilize a partially coherent X-ray beam generated by a micro-focused X-ray source with a small focal spot size. A spatial beam modulator such as a random phase object, e.g., silicon carbide sandpaper, is placed between the source and the sample to create a random granular speckle pattern. The system employs a high-resolution detection setup with a thin scintillator and a spatially resolved detector with small pixel size to capture shifts in the speckle pattern caused by the sample's refraction effects. By analyzing these shifts, the system computes phase gradients and integrates them to produce detailed phase images, enhancing contrast in low-atomic-number materials like soft tissues and polymers. The compact design reduces source-to-detector distance, improving flux efficiency and system throughput while enabling high-resolution, three-dimensional tomographic imaging.
Owner:CARL ZEISS X-RAY MICROSCOPY INC

Device and method for detecting the position of a body, as well as coordinate measuring machine

Device (10) for detecting the position of a body (12), in particular for detecting errors in several degrees of freedom, wherein the device (10) comprises a transmitter unit (14), at least one spatially resolving sensor (16), an evaluation and control unit (18), and a target element (20) with three retroreflectors (22), wherein the transmitter unit (14) is configured to emit three parallel light beams (24), wherein the retroreflectors (22) are configured to reflect one of the three light beams (24) back to the transmitter unit (14) as a retroreflected light beam (26), wherein the at least one spatially resolving sensor (16) is configured to detect a first signal, wherein the transmitter unit (14) is configured to detect a second signal from the three retroreflected light beams (26), and wherein the evaluation and control unit (18) is configuredto determine, by means of the first signal and the second signal, six degrees of freedom of the body (12) exhibiting a position error (48), a first translation error (50), a second translation error (52), a roll error (54), a yaw error (56) and a pitch error (58), wherein the evaluation and control device (18) is configured to determine, by means of the first signal, the first translation error (50), the second translation error (52) and the roll error (54) and, by means of the second signal, the position error (48), the yaw error (56) and the pitch error (58).
Owner:CARL ZEISS INDUSTRIELLE MESSTECHNIKE GMBH

Differential phase polarimeter

The invention relates to a differential phase polarimeter (10), comprising a light source (12) for polarized irradiation light (14); a sample chamber (16) for a test object (18), the sample chamber (16) being arranged such that the test object (18) can be irradiated with the irradiation light (14); a linear polarizer (20) arranged downstream of the sample chamber (16) in the light propagation direction; and a detector (22) arranged downstream of the linear polarizer (20) in the light propagation direction and designed to detect a light intensity of the irradiation light (14) which has passed through the linear polarizer (20); wherein the detector (22) is spatially resolving and arranged in such a way that both test object light (32) which has passed through the test object (18) and background light (34) which has not passed through the test object (18) can be detected.
Owner:PHYSIKALISCH TECHNISCHE BUNDESANSTALT

Method and apparatus for spatially resolved measurement of a physical quantity

Method for spatially resolved measurement of a physical quantity, comprising the following process steps: Laser radiation is generated, the laser radiation is modulated, the method utilizing an OFDR measurement technique in which amplitude-modulated signals are formed from the laser radiation by modulation with modulation frequencies, the modulation frequency being changed in successive time intervals such that in a first time interval the laser radiation is modulated with at least one first modulation frequency and that in a second time interval, which follows the first time interval, the laser radiation is modulated with at least one second modulation frequency which is different from the first modulation frequency, to measure the physical quantity the modulated laser radiation is coupled into an optical fiber (3),Backscatter signals are generated in the optical fiber (3) by the laser radiation, the backscatter signals are coupled out of the optical fiber (3), the backscatter signals coupled out of the optical fiber (3) are detected, the physical quantity is determined spatially resolved from the detected backscatter signals, wherein, in the modulation of the laser radiation, the amplitude of the laser radiation is modulated with at least two different modulation frequencies in each time interval.
Owner:LUNA INNOVATIONS GERMANY GMBH

Apparatus and method for measuring alignment errors of directional beam sources

An apparatus for measuring alignment errors of a laser diode or other directional beam source (12) includes a holder (22) for the beam source (12) rotatably mounted about an axis of rotation (18) by a drive (18). The apparatus also includes a first spatially resolved radiation sensor (36), a beam splitter (26) that splits a beam (24) generated by the beam source (12) into a first partial beam (28) and a second partial beam (30), and focusing optics (32). The focusing optics is positioned in the radiation path of the first partial beam (28) and has a focal plane in which the first radiation sensor (36) is positioned. A second spatially resolved radiation sensor (38) is positioned in the radiation path of the second partial beam (30). The computing device (40) calculates the tilt (d) and lateral shift (α) of the beam (24) generated by the beam source (12) from a first position on the first radiation sensor (36) swept by the first partial beam (28) during rotation of the beam source (12), and from a second position on the second radiation sensor (38) swept by the second partial beam (30) during rotation of the beam source (12).
Owner:TRIOPTICS GMBH

System and method for detecting optical signals from a test object moving relative to a target

The invention relates to a system (100) for detecting optical signals (20) of a test object (10) moving relative to a target (50) in the intended test state, wherein the test object (10) has at least one light source (12) for transmitting the optical signals (20), comprising at least one optical receiving unit (30) for receiving the optical signals (20) of the at least one light source (12), wherein the optical receiving unit (30) is configured for high-speed digital data acquisition with spatially resolved addressable pixels, particularly in the microsecond range, wherein the at least one light source (12) is directed towards the optical receiving unit (30), and wherein an intensity of the optical signals (20) is stored in the pixels of temporally successive recordings of the optical receiving unit (30).Furthermore, the invention relates to a method for detecting optical signals (20) of a test object (10) moving in a test state as intended using such a system (100).
Owner:DEUTSCHES ZENTRUM FÜR LUFT UND RAUMFAHRT E V

Procedures for functional testing and calibration of an ophthalmic laser therapy device

The present invention relates to a method for functional testing of a laser device (110) of an ophthalmological laser therapy device (100). The task is solved by a method comprising: providing (F1, K3) test signals representing a plurality of spaced laser pulses of the laser device (110) into a working area (160, 260) within a test volume (150, 250) containing hyaluronic acid, acquiring (F2, K4) a spatially resolved data set to detect an interaction between the laser pulses and the test volume (150, 250), and spatially resolving (F3, K5) checking the data set for interaction. The task is further solved by a suitable calibration procedure, a calibration unit (K), an ophthalmic laser therapy device (100), a computer program product and a suitable testing device (200).
Owner:CARL ZEISS MEDITEC AG

Function testing method and calibration method for an ophthalmological laser therapy device

PCT designated stageWO2026052633A1Laser surgerySpatially resolvedData set
The present invention relates to a function testing method for a laser apparatus (110) of an ophthalmological laser therapy device (100). The problem is solved by a method which comprises: providing (F1, K3) test signals which represent a plurality of spaced-apart laser pulses of the laser apparatus (110) in an operating region (160, 260) within a test volume (150, 250) comprising hyaluronic acid, acquiring (F2, K4) a spatially resolved data set for detecting an interaction between the laser pulses and the test volume (150, 250), and performing a spatially resolved check (F3, K5) of the data set for interaction. The problem is also solved by a corresponding calibration method, a calibration unit (K), an ophthalmological laser therapy device (100), a computer program product and by a corresponding checking apparatus (200).
Owner:CARL ZEISS MEDITEC AG

Method and apparatus for additive manufacturing of a workpiece

ActiveCN113874141BSpatially resolvedData set
The present invention relates to a method and apparatus for additive manufacturing of a workpiece (14) using a dataset (34) that defines the workpiece (14) in multiple layers (16) arranged vertically above each other. A construction tool (24) moves a first energy beam (26) relative to a manufacturing platform (12) in a spatially resolved manner. A measuring device (36) determines various characteristics of the layer stack (20). The measuring device (36) includes an exciter (38) that excites the stack (20) by means of a second energy beam (42), and a detector (40) that detects the characteristics of the stack (20) as a result of the excitation in a spatially resolved manner. A controller (30) controls the second energy beam (42) and / or a detection path (44) to perform measurements along multiple measurement trajectories (46), which may differ from the trajectory (28) of the first energy beam (26). The first scanning unit (50) and the additional scanning unit (54) establish beam paths that are completely separate from each other for the first energy beam (26) and the second energy beam (42) and / or for the first energy beam (26) and the detection path (44).
Owner:CARL ZEISS AG +1

Spectrometer with rotated volume Bragg grating

A spectrometer may include a rotated volume Bragg grating (r-VBG) within a volume of a material having an input face, where the r-VBG reflects portions of input light propagating through the input face that satisfies a Bragg condition for wavelengths within a spectral band, where a period of the r-VBG along the grating vector is chirped to vary along the grating vector to provide that the Bragg condition is satisfied for different wavelengths at different depths, and where a spectrum of the input light is spatially resolved in the reflected portions of the input light by the r-VBG. The spectrometer may further include a multi-pixel detector configured to receive the reflected portions of the input light from the r-VBG, where the multi-pixel detector is configured to output spectral data indicative of the spectrum of the input light within the spectral band.
Owner:UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC