61 results about "Nerve activity" patented technology

The invention provides a cognitive function evaluation method based on neurovascular coupling analysis. The method comprises a signal preprocessing step, a signal processing step, a feature extraction step and a coupling coefficient calculation step. A new normal form of cognitive evaluation is constructed from nerve-blood vessel coupling and cross-system cooperation dimensions, and accurate description of a cognitive state is realized through real-time quantification of a dynamic cooperation effect of brain nerve activity (EEG) and blood flow regulation (CBP variability) and establishment of an association relationship between a dynamic cooperation index and cognitive ability (alertness, reaction speed and memory). And a new objective basis is provided for the fields of plateau medicine, intelligent health, neurological and mental disease diagnosis and treatment and the like.

The invention discloses a cognitive function intervention method and system based on multi-mode space-time dynamic decoding biological feedback, and belongs to the technical field of artificial intelligence algorithms and noninvasive nerve regulation. According to the method, brain nerve activity signals and autonomic nerve cooperation signals are captured in real time, the signals are subjected to standardization processing by adopting a multi-modal signal cascade preprocessing algorithm, and cognitive feature extraction of fusion signals and dynamic distribution of multi-modal signal feature weights are realized in combination with a circulating double-flow self-encoding model; and thus, the individual cognitive state is accurately evaluated. And based on the evaluated cognitive state, dynamically identifying and quantifying into self-perceived visual and auditory stimuli, and constructing an iterative closed-loop feedback cognitive nerve plasticity regulation loop to realize individualized targeted regulation of the cognitive function. The method is suitable for non-invasive individualized intervention of the cognitive function of the Parkinson's disease patient, and has remarkable clinical application potential and social value.

Described herein are systems and methods for applying extremely low duty-cycle stimulation sufficient to treat chronic inflammation using feedback to adjust the off times between stimulations. In particular, the feedback include an assessment of the level of inflammation by the patient or the healthcare provider, or by measure the level of an inflammatory analyte or biomarker, or by detecting nerve activity correlated with inflammation.

The invention relates to the technical field of magnetic stimulation therapy, in particular to a magnetic convulsion therapy coulometric titration method and system based on individualized epilepsy prediction.Based on epilepsy prediction, intervention time periods are divided, electroencephalogram is collected to extract the phase change trend, and magnetic stimulation applying modes consistent in space direction are matched and screened; stimulation is executed, nerve electrical activity evolution is monitored, nerve response area distribution is concluded, a time period sequence, a response area form and an application trend are synthesized, a stimulation energy configuration range is divided and limited, and a magnetic convulsion treatment electricity titration result is formed. According to the method, epilepsy risks are described in a staged mode, time sequence correlation is established, intervention is endowed with dynamic distinguishing capacity, the stimulation direction is restrained according to phase propagation characteristics, the stimulation path is kept consistent with the dominant direction of neural activity, the energy range is limited in combination with neural response distribution, energy and state mapping is established, and the intervention matching degree and regulation controllability are improved; the invalid stimulation probability is reduced, and the treatment adaptation capability is enhanced.

Systems and methods of applying electrical stimulation to achieve sustained relief of chronic pain that comprise a coiled wire percutaneous lead configured for insertion into a portion of a body that is proximal to a region of pain and an electrode formed integrally on the coiled wire percutaneous lead, wherein the electrode is configured to be positioned inside the body and at a therapeutically effective distance from a portion of at least one peripheral nerve that innervates the region of pain. The systems and method may also include an electrical stimulation device operatively coupled to the lead to apply electrical stimulation through the at least one electrode to at least one peripheral nerve that innervates the region of pain, to activate target peripheral nerve fibers while preventing activation of non-target peripheral nerve fibers and avoiding changing or blocking neural activity in off-target peripheral nerve fibers in the at least one peripheral nerve to create comfortable sensations in the region of pain and produce pain relief by modulating central nervous system plasticity associated with the pain.

The invention provides a lower limb rehabilitation evaluation method, system and device based on a brain-computer interface and a medium, and relates to the technical field of rehabilitation medicine and medical electronics. According to a lower limb rehabilitation evaluation technology based on a brain-computer interface, a two-way evaluation system of peripheral muscle form-central nervous activity is constructed through synchronous acquisition of wearable A-type ultrasound and electroencephalogram signals; a-type ultrasound monitors the change of the thickness of the rectus femoris in real time, and electroencephalogram signals analyze the coherence of Alpha / Beta frequency bands, so that functional difference evaluation of a stroke patient in a resting state, a passive motion state and an active motion state with different resistances is realized, the limitation of single subjective scoring of a traditional scale is avoided, and a multi-dimensional quantitative index is provided for rehabilitation evaluation.

The invention relates to the technical field of neutrophile granulocyte separation, in particular to a mouse neutrophile granulocyte separation method which comprises the following steps: (1) anesthetizing and disinfecting a mouse; (2) tissue sampling; (3) tissue digestion; (4) preparing a cell suspension; (5) purifying cells; (6) cell culture; according to the method disclosed by the invention, isoflurane is adopted in the anesthesia disinfection step, so that central nervous activity of mice can be rapidly inhibited, tissue damage caused by stress reaction is avoided, and chemical stimulation can be reduced while body surface microorganisms are cleared through combination of ethanol disinfection and sterile normal saline flushing, and aortic tissues with intact activity are provided for subsequent material taking. In the compound enzyme digestive juice, collagenase I can specifically degrade aortic wall collagenous fibers, trypsin dissociates adhesion connection between cells, neutral protease assists in decomposing elastic fibers, and DNA enzyme I is supplemented to inhibit cell aggregation, so that the contradiction between incomplete digestion and large cell damage of the traditional enzyme juice is effectively solved.

Provided are devices, systems, and methods for treating or preventing heart failure or a symptom of heart failure through coordinated nerve activity interruption for one or more target nerves. Devices disclosed herein may comprise a vascular catheter comprising a telescopic needle assembly configured to puncture vascular tissue in contact with the catheter, wherein the needle assembly comprises one or more electrodes configured to deliver electrical energy to a tissue in contact with the one or more electrodes. Methods may include treating or preventing heart failure or a symptom of heart failure by inserting a catheter into a vascular tissue of the subject; guiding the catheter towards the greater splanchnic nerve; piercing the vascular tissue of the subject with a telescopic needle assembly extending outwards from the catheter towards the target nerve; and ablating the target nerve by delivering a stimulation energy to the target nerve with one or more electrodes.

The invention provides a creativity psychological assessment method based on artificial intelligence and a reinforcement learning model, and relates to the technical field of creativity psychological assessment. According to the method, the attention entropy value is calculated through the eye movement data, the multi-dimensional feature vector is constructed in combination with standardization processing of the prefrontal lobe Gamma wave band electroencephalogram signals, quantitative characterization of the attention distribution and cranial nerve activity cooperation state is achieved, the one-sidedness of traditional single signal evaluation is broken through, and meanwhile, the method has the advantages of being simple in structure and convenient to operate. A reinforcement learning task decision engine dynamically matches an evaluation task according to a real-time cognitive state, so that a task type is highly matched with individual cognitive features, more real creativity performance is captured, a reinforcement learning model driven by a multi-dimensional reward mechanism is continuously optimized, evaluation not only reflects a surface behavior result, but also improves the performance of the system. And the internal law of the cognitive process can be mined, and a quantitative basis is provided for creativity psychological mechanism research.

The invention relates to the technical field of mental health evaluation, and discloses a physical exercise-based mental health evaluation system and method. The method comprises the following steps: acquiring kinematics data, physiological waveforms and behavior images synchronously recorded by a user in an exercise cycle, and forming a fusion data stream through a time mark alignment technology; extracting motion mode features, nerve activation features reflecting central nervous activity and time sequence change features of facial micro-expressions from the data stream; inputting the features into a pre-constructed psychological state inference model, generating a quantization vector representing a psychological load state, performing comprehensive judgment in combination with a historical baseline file of the user, and outputting a psychological health assessment result; by realizing millisecond-level synchronous fusion of multi-modal data and mining deep time sequence characteristics of neural electrical activities and micro expressions, the method overcomes the limitation of traditional single-modal or non-synchronous data evaluation, and improves the accuracy and objectivity of dynamic monitoring of psychological states.

The invention discloses an animal olfactory behavior training experiment device, relates to the technical field of animal behavioristics experiment devices, can be cooperatively used with an external nerve recording system and a behavior detection analysis system, and aims to explore a correlation mechanism among smell stimulation, behavior response and nerve activity. The device adopts a radial single-starting-point and multi-terminal-point space structure, and is combined with a multi-odor channel system with physical isolation, so that approaching or avoiding behaviors of animals can be accurately induced. The system is integrated with an intelligent closed-loop control module based on an STM32 single-chip microcomputer, and a graded gas path cleaning mechanism is designed and comprises the functions of countercurrent purging, ultraviolet photolysis, electronic nose cleaning verification and the like, so that the purity of odor stimulation and the reliability of the experimental process are ensured. Meanwhile, the device supports TTL synchronization signal output with millisecond-level precision, can be seamlessly connected with commercially available electrophysiology and behavioristics equipment, and is suitable for multi-mode animal behavior training, recording and regulation scenes.

The present application relates to the technical field of electrochemical devices, and provides an electrochemical device for simulating biological signals and a preparation method thereof.The electrochemical device for simulating biological signals is composed of N double-gate structure units, the correlation between the structure units is realized by forming a common gate between one of the lower gate and the upper gate of each double-gate structure unit and one of the lower gate and the upper gate of each other double-gate structure unit, the mutual influence and restriction between each structure unit are realized, and each double-gate structure unit is changed by adjusting the thickness of the electrolyte layer and other conditions, so that the electrochemical device can present the global regulation and mutual induction of nerve activity.

The invention discloses a nerve and blood vessel coupling model personalized real-time regulation and control method and device based on transcranial direct current stimulation response. According to the device, finite element simulation modeling and large-scale dynamic average field model building are carried out by obtaining multi-modal data (such as T1w, DWI and rs-fMRI) of a patient, and electric field distribution and neuron group activity of tDCS in the brain are simulated. In combination with nerve and blood vessel coupling characteristics, an individualized tDCS real-time regulation and control model is constructed, and stimulation parameters such as current intensity, electrode position and stimulation duration are dynamically adjusted. In the regulation and control process, neural activity and cerebral blood flow changes are monitored in real time, and the stimulation effect is optimized through a closed-loop feedback mechanism. The problems of individual difference, inaccurate real-time feedback and complicated equipment in the existing tDCS regulation and control are solved, the dependence on high-end equipment is reduced, the operation process is simplified, the accuracy and effectiveness of a personalized regulation and control scheme are improved, and the method is suitable for wide application in a clinical environment.

Systems and methods for treating Inflammatory Bowel Disease (IBD) using neuromodulation are described herein. For example, IBD can be treated by delivering an electrical signal to one or more sacral nerves of a patient via a signal delivery device positioned proximate one or more of the patient's sacral nerves. In some embodiments, the electrical signal can modulate neural activity in the patient, which may in turn reduce inflammation in the patient by altering an imbalance between the patient's sympathetic nervous system and parasympathetic nervous system, and / or modifying a threshold for an inflammatory response in the gastrointestinal system.

The application provides a kind of nanorobot and its control method, carry the modified reverse sodium-potassium pump, can long time, continuously use the ion concentration change of organism itself to realize the regulation of nerve activity, can be widely applied to the intervention of a variety of nervous system excitation / inhibition imbalance related neurological diseases;Through the recognition of specific neuron's axon hillock initial segment by the potential receptor and field driving element, more accurate targeted regulation can be achieved;Through the characteristics of precise control of movement of ultrasonic wave of ultrasonic wave driving element, combined with imaging equipment, brain region targeted movement of nanorobot is realized, the nanorobot and its control method provided by the application improve the existing nanorobot, through the modified functional element, to realize the target brain region targeted guidance, neuron recognition and long-term regulation.

The embodiment of the invention provides an intelligent detection system and device based on ventricular assist equipment, and relates to the technical field of medical instruments.The system comprises the ventricular assist equipment and detection equipment, and the ventricular assist equipment is implanted into the heart of a patient in a percutaneous intervention mode and assists the heart of the patient in blood pumping; the detection device is used for detecting physiological nerve parameters of a patient during operation of the ventricular assist device, and the detection device executes the following intelligent detection method: acquiring a physical measurement signal at the current moment; mapping the physical measurement signal into a target discharge frequency of the baroreceptor according to a preset nonlinear mapping relation; and based on the target discharge frequency, adopting a physiological correlation model to predict the target neural activity of the patient. By applying the scheme provided by the embodiment, the autonomic nerve regulation state of the patient can be accurately and continuously evaluated.

To enable users to easily identify potential placement locations for intravascular electrodes that are close to the source of the nerve activity being measured. [Solution] The medical image processing apparatus according to the embodiment comprises a vessel diameter image generation unit, a distance image generation unit, a device implantation position candidate identification unit, and a display control unit. The vessel diameter image generation unit generates a vessel diameter image representing the size of the vessel diameter inside the brain from a cerebral vessel image taken of the blood vessels of the brain. The distance image generation unit identifies a target position corresponding to the neural activity that is the target of measurement inside the brain, based on an image relating to at least one of the functional areas of the brain and the arrangement of nerves inside the brain, and generates a distance image showing the distance to the identified target position. The device implantation position candidate identification unit identifies a position on the vessel where both the vessel diameter and the distance from the target position satisfy a specified criterion, based on the vessel diameter image and the distance image, as a candidate for device implantation position. The display control unit highlights the identified implantation position candidate on an image representing the brain.

The application discloses a scalp EEG signal-based brain internal nerve activity tracing method and system, and the method comprises the following steps: a virtual brain model is built by using a neurocluster model with biological interpretation, a whole brain map and brain physiological connection, and the number of the neurocluster model is recorded; brain internal nerve activity generated by the virtual brain model is converted into scalp EEG signals according to an EEG measurement model; a brain internal nerve activity tracing neural network is constructed; internal brain activity data with spatial characteristics and time characteristics are generated by using the virtual brain model, and corresponding EEG signals are obtained through the EEG measurement model; the obtained internal brain activity data and the corresponding EEG signals are used to construct a data set for training the brain internal nerve activity tracing neural network. The brain internal nerve activity tracing neural network is constructed by cascading a spatial module and a time module, so that the stability and accuracy of brain internal nerve activity tracing are improved.

1. The name of the design product: insomnia treatment instrument of transcranial magnetic. 2. The use of the design product: for stimulating the cerebral cortex by magnetic field, adjusting the brain nerve activity. 3. The design points of the design product: in shape. 4. The picture or photo that can best show the design points: perspective drawing.

The present application relates to the fields of medicine, health care products and food technology, and in particular to a traditional Chinese medicine composition for mood and cognitive impairment caused by degenerative diseases, which is made of the following raw materials by weight: 1-35 parts of radix puerariae, 1-35 parts of semen ziziphi spinosae, 1-35 parts of radix bupleuri, 1-35 parts of clematis, 1-35 parts of radix astragali, and 1-35 parts of herba eriodes. The present application has the effects of preventing and treating mood and cognitive impairment caused by various degenerative diseases, reducing anxiety-like response and depression level caused by degenerative diseases, preventing overexcitability of the nervous system, significantly improving learning and cognitive ability, and having stable effects without inhibiting normal nerve activity and hormone level.

Embodiments described herein include a system including a catheter defining a lumen and an exit port, and carrying a first set of electrodes and a second set of electrodes configured to deliver stimulation energy or detect a signal in response to stimulation energy. The catheter is configured to be inserted through an azygous vein and into an intercostal vein branching off the azygous vein such that the first set of electrodes are disposed within the intercostal vein adjacent a splanchnic nerve of the subject and the second set of electrodes are disposed within the azygous vein. The system can include an ablation probe configured to be slidably disposed within the lumen and advanceable through the exit port of the catheter to pierce at least one of the azygous vein or the intercostal vein and ablate the splanchnic nerve.

System and methods for monitoring and / or controlling nerve activity in a subject are provided. In one embodiment, a system includes electrodes configured to be placed proximate to a subject's skin, and a signal detector configured to detect electrical signals using the electrodes. The system also includes a signal processor configured to receive the electrical signals to generate filtered signals, the filter configured to attenuate at least signals having frequencies corresponding to heart muscle activity during a heartbeat. The signal processor is also configured to identify a skin nerve activity using the filtered signals, estimate a sympathetic nerve activity using the identified skin nerve activity, and further to generate a report indicative of the estimated sympathetic nerve activity. In some aspects, the system further includes a signal generator to deliver the electrical stimulation to the subject's skin.

The present invention in some embodiments thereof relates to a method for selectively modifying nerve activity without causing substantial damage to non-targeted tissue, comprising introducing a catheter device comprising one or more ultrasonic transceivers to the pulmonary artery lumen, receiving, using the one or more ultrasonic transceivers, echo signals reflected from the non-targeted tissue following emission of ultrasound energy by the one or more transceivers, analyzing the received echo signals to identify at least one of a type and location of the non-targeted tissue relative to the one or more transceivers, and emitting ultrasound energy from the one or more ultrasonic transceivers in accordance with the analysis, to modify nerve activity without substantially damaging the identified non-targeted tissue.

The invention discloses an electronic functional fibroin nerve repair conduit with an electronic structure, a preparation method and application thereof. An electric conductor is embedded in the neural restoration catheter and is used for applying electrical stimulation in situ or collecting neural electrophysiological signals; the preparation method comprises the following steps: manufacturing a conduit wall with electronic functionalization by utilizing a silk fibroin solution and a nerve conduit core layer material, performing directional freezing treatment on the conduit wall by utilizing a plastic pipe, a specific copper block and the nerve conduit core layer material, and then performing freeze drying on the whole conduit subjected to the directional freezing treatment. Therefore, an oriented porous material structure is formed in the conduit, and finally the electronic functional fibroin nerve repair conduit with an electronic structure is formed. The electronic functional catheter provides stable and lasting electrical stimulation conduction, promotes nerve fiber regeneration and functional recovery, promotes neuron repair, prevents secondary mechanical damage to nerves, and can also be used for collecting nerve activity conditions in a repair area and monitoring the nerve repair process.

The application provides a pregnant woman's prenatal and postpartum emotion monitoring management method, a computer program and an electronic device, directly reflects electroencephalogram signals of brain nerve activities as objective basis for emotion judgment, and carries out electroencephalogram signal denoising based on time sequence de-correlation source separation and intrinsic time scale decomposition, recovers the denoised electroencephalogram signals from strong noise backgrounds specific to pregnant women and lying-in women, provides a high-quality signal basis for subsequent feature extraction and risk judgment, and improves the accuracy and reliability of overall monitoring analysis. The deviation of each feature in the postpartum second emotion-related multi-dimensional feature relative to the feature baseline of the corresponding feature is calculated, the postpartum emotion state of the pregnant woman is determined, emotion intervention is carried out, the upgrade of the pregnant woman's emotion management from passive response to active and individualized whole-cycle management is realized, the perinatal emotional abnormality risk can be identified early, the perinatal emotional health management is promoted to be precise, and the application has high clinical practical value.

Devices, systems, and methods are provided for treating or preventing heart failure or symptoms of heart failure by coordinated disruption of neural activity to one or more target nerves. A device disclosed herein may include a vascular catheter comprising a retractable needle assembly configured to puncture vascular tissue in contact with the catheter, the needle assembly comprising one or more electrodes configured to deliver electrical energy to tissue in contact with one or more electrodes. A method may include treating or preventing heart failure or symptoms of heart failure by inserting the catheter into the vascular tissue of a patient, guiding the catheter toward the greater splanchnic nerve, puncturing the patient's vascular tissue with a retractable needle assembly extending outward from the catheter toward the target nerve, and dissecting the target nerve by delivering stimulating energy to the target nerve using one or more electrodes.

The present invention in some embodiments thereof relates to a method for selectively modifying nerve activity without causing substantial damage to non-targeted tissue, comprising introducing a catheter device comprising one or more ultrasonic transceivers to the pulmonary artery lumen, receiving, using the one or more ultrasonic transceivers, echo signals reflected from the non-targeted tissue following emission of ultrasound energy by the one or more transceivers, analyzing the received echo signals to identify at least one of a type and location of the non-targeted tissue relative to the one or more transceivers, and emitting ultrasound energy from the one or more ultrasonic transceivers in accordance with the analysis, to modify nerve activity without substantially damaging the identified non-targeted tissue.

The application belongs to the technical field of biological medicine, and particularly relates to application of (E)-BCI hydrochloride in preparation of a medicine for treating sepsis. The application provides application of (E)-BCI hydrochloride in preparation of the medicine for treating sepsis. (E)-BCI hydrochloride regulates a DRD1 gene through targeting, quiets an interferon stimulation storm, reduces abnormal activation of astrocytes, reduces a level of an inflammatory factor, improves expression of a nerve activity gene, and provides a non-antibiotic dependent medicine for sepsis treatment from a new target point of regulating inflammation and immune balance, and is particularly suitable for systemic inflammatory response syndrome caused by various causes such as infection, operation and trauma, and has a wide clinical application prospect.

The invention relates to the technical field of biomedical engineering, and discloses a renal sympathetic nerve nuclide evaluation system and method for RDN, and the system comprises a nuclide image collection module, a data analysis module, a nuclide kinetic parameter analysis module, a neural activity quantification module and a dynamic evaluation and decision module, and is used for collecting a nuclide image data set; identifying a kidney area in the nuclide image data set, and analyzing the radioactivity counting rate of the kidney area; analyzing an uptake index and a retention index of the radionuclide marker based on the radioactivity counting rate; analyzing a sympathetic nerve activity quantitative index of the kidney region according to the uptake index, the retention index and the electrocardio physiological data; and determining a dynamic threshold value of the sympathetic nerve activity quantitative index based on the activity expression level index of the target object, and performing dynamic analysis on the sympathetic nerve activity quantitative index according to the dynamic threshold value to obtain an evaluation index. According to the invention, the accuracy of kidney sympathetic nerve nuclide evaluation can be improved.