33 results about "Catecholamine" patented technology

The present application is applicable to the field of medical devices, and discloses a liquid chromatography-mass spectrometry apparatus and a control method for the liquid chromatography-mass spectrometry apparatus. The liquid chromatography-mass spectrometry apparatus comprises a sample storage device, a pretreatment device, a chromatography device, a mass spectrometry detection device, and a controller. The chromatography device comprises a test solution preparation channel, a test solution transfer assembly, a liquid phase fluid delivery assembly, and a chromatography column. An operating pressure outputted by the liquid phase fluid delivery assembly is less than or equal to 20 MPa. The length of the chromatography column is greater than or equal to 3 mm and less than or equal to 35 mm. A sample comprises a target substance to be measured, and the target substance to be measured comprises at least one of vitamin D, a steroid hormone, and a catecholamine. The present application reduces costs of the liquid chromatography-mass spectrometry apparatus.

The present invention provides sulfamate derivative prodrugs of the dopamine agonist (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol, their use in treating conditions for which treatment with a dopamine agonist has therapeutic benefit, and pharmaceutical compositions comprising a compound of the present invention. The compounds according to the present invention have the formula (Id), wherein R1and R2are each independently selected from H and the substituent (iii) below, wherein * indicates the point of attachment to oxygen, wherein R3is selected from H and COR4, and wherein R4is selected from H and C1-C6alkyl, with the proviso that R1and R2cannot both be H, 15or a pharmaceutically acceptable salt thereof.

The present invention relates to a vanillic acid derivative compound which can be formed by a dehydration condensation reaction between vanillic acid and catecholamine. The vanillic acid derivative compound according to the present invention is characterized in that it can be used as a therapeutic preparation for Alzheimer's disease and neuroinflammation. In addition, the present invention relates to a therapeutic composition for Alzheimer's disease and a therapeutic composition for neuroinflammation, each of which comprises the compound.

Provided herein are methods and materials for preventing cytokine release syndrome (CRS). For example, methods and materials for using one or more catecholamine inhibitors to prevent a mammal from developing CRS are provided.

The purpose of the present disclosure is to provide a novel plant environmental stress alleviator, a plant growth promoter, and a plant DNA repair promoter that have an excellent effect of alleviating environmental stresses such as high temperatures.　The present disclosure provides a plant environmental stress alleviator, a plant growth promoter, and a plant DNA repair promoter containing: one or more neurotransmitters selected from choline esters, catecholamines, serotonin, and amino acids, and / or one or more acetylcholinesterase inhibitors selected from polyphenols, flavonoids, and organic acids, or a plant extract containing said inhibitors; and calcium ions. The present disclosure also provides a method for producing the aforementioned agents.

The application discloses a method and a kit for detecting catecholamine and its metabolites in urine, and comprises the following steps: adding an internal standard working solution to a urine sample to be detected, mixing, then adding butyric anhydride solution, mixing, and then oscillating and mixing at 20-35 DEG C for 5-30 min to perform a derivatization reaction; after the derivatization reaction is completed, centrifugation is performed, the supernatant is taken, and liquid chromatography tandem mass spectrometry is used for detection. The toxicity and danger of butyric anhydride are low, the by-product after derivatization is only butyric acid, and the by-product does not interfere with catecholamine substance detection, and a neutral or weakly alkaline environment with a pH of 7.0-8.0 can meet the derivatization conditions. Since the pretreatment time is short, and the structure is changed after derivatization, the stability of catecholamine prototype substances is improved, meanwhile, the structure after derivatization is more easily ionized in a mass spectrometry ion source, the substance response intensity is also increased, and the detection result is more reliable.

The invention relates to the technical field of catecholamine detection, in particular to a copper-doped carbon dot with similar catechol oxidase activity as well as a preparation method and application of the copper-doped carbon dot. The copper-doped carbon dot provided by the invention can be used as a nano-enzyme for specific catalytic oxidation of catecholamine, so that catecholamine is detected by a colorimetric method. Copper atoms in the copper-doped carbon dots are dispersed in a monatomic form, and a local coordination structure is Cu-N3O which is similar to metal active sites in natural enzyme; according to the structure, the electron transfer capability and the redox activity of a Cu center are remarkably enhanced, so that the structure shows efficient catalytic activity and substrate specificity in a catecholamine oxidation reaction.

The present invention provides compounds of formula (I) that are prodrugs of catecholamine for use in treatment of neurodegenerative diseases and disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating neurodegenerative or neuropsychiatric diseases and disorders using the compounds of the invention, in particular Parkinson's disease. Accordingly, the present invention relates to compounds of formula (Id) wherein R1 is H and R2 is selected from one of the substituents (i) and (ii) below; or R1 is selected from one of the substituents (i) and (ii) below and R2 is H; or R1 and R2 are both represented by substituent (i) below; or R1 and R2 are both represented by substituent (ii) below; or R1 is substituent (i) and R2 is substituent (ii); or R1 is substituent (ii) and R2 is substituent (i); wherein * indicates the attachment point; and wherein the carbon atom at the attachment point on substituent (i) is in the S-configuration; or a pharmaceutically acceptable salt thereof.

The present invention relates to a compound of formula (I) as inhibitors of calcium calmodulin dependent protein kinase 2 (CAMK2) for the treatment of for the treatment of heart failure, fibrosis, cardiomyopathies, atrial fibrillation, catecholaminergic polymeric ventricular tachycardia, heart block, cardiac arrhythmias, contraception, anxiety, post-traumatic stress disorder, hypertension, tachycardia, diabetes, allergy, and asthma.

The invention relates to the technical field of catecholamine detection, in particular to a high-sensitivity diagnostic kit for detecting catecholamine, which comprises air inlet baffles with filter meshes in the middle, the air inlet baffles are mounted on two sides of the lower end of a bottom component, and a storage component is mounted in the bottom component. One side of the upper end of the bottom assembly is rotationally connected with the top assembly through a connecting piece, the other side of the upper end of the bottom assembly is fixedly connected with a magnetic attraction block, one side of the bottom assembly is fixedly connected with a constant-temperature fan and an air guide bent pipe, and the other side of the bottom assembly is fixedly connected with an air guide plate. According to the invention, the flow direction of the air flow is controlled, the air flow can be used for driving the test tube to rotate, the contact probability of detection liquid in the test tube is enhanced, the detection efficiency and accuracy are improved, and meanwhile, in the process, negative pressure can be formed at the bottom of the kit, so that the kit is stably adsorbed on the detection table, the vibration is small, and the detection accuracy is improved. And the stability in the detection process is further improved.

The invention discloses an epoxy resin flame retardant based on a one-dimensional-two-dimensional layered structure nano hybrid as well as a preparation method and application of the epoxy resin flame retardant. According to the flame retardant, graphene oxide (GO) is used as a matrix, GO-APTES with larger interlayer spacing is obtained by modifying GO through APTES, and nanosheets are more dispersed. Then, dopamine is oxidized and self-polymerized under the alkaline condition to form a PDA coating, the surface of the beta-FeOOH nanorod is uniformly coated with the PDA coating, and beta-FeOOH is densely and stably loaded on GO-APTES nanosheets through the interaction of rich catechol / amine groups of the PDA coating and strong hydrogen bonds on the surface of GO-APTES, so that a GA (at) PDA (at) beta-FeOOH nanohybrid is prepared; the obtained GA (at) PDA (at) beta-FeOOH nano hybrid has good dispersibility in an epoxy resin matrix. When the flame retardant is applied to epoxy resin, the thermal stability and flame retardance of a composite material can be remarkably improved.

The invention belongs to the technical field of biomedical detection, and relates to a kit and a method for simultaneously detecting catecholamine compounds, metabolites thereof and creatinine in human urine or plasma based on a derivatization method. A method for simultaneously detecting catecholamine compounds, metabolites thereof and creatinine in human urine or plasma based on a derivatization method comprises the following steps: respectively adding an internal standard working solution into a series of calibration products, a series of quality control products, a plasma sample and a urine sample, and uniformly mixing; adding a precipitant, uniformly mixing and centrifuging; taking supernate, carrying out nitrogen blowing and drying, adding a sample adjusting solution, and uniformly mixing; a derivatization reagent is added for a derivatization reaction, and a derivatization reaction solution is taken for LC-MS / MS detection analysis. The method breaks through the bottleneck of synchronous detection, realizes synchronous detection of catecholamine, metabolites thereof and creatinine in plasma and random urine for the first time, does not need multiple operations, obtains a whole set of core indexes required by clinical diagnosis at one time, and greatly improves the detection efficiency.

This invention provides a foam modifier, its preparation method, and its application. The foam modifier comprises a surfactant, nanoparticles, and water; the surfactant includes anionic gemini surfactants and anionic nonionic surfactants; the nanoparticles are catecholamine polymer particles. The structural formula of the anionic gemini surfactant is [insert structural formula here], and the structural formula of the anionic nonionic surfactant is R6-O-(R8-O). n -R7; The foaming agent described has good foaming properties and good stability under high-salt and high-calcium-magnesium conditions, and can be applied in high-salt reservoirs.

The application discloses a metal complex photosensitizer and a catecholamine coordination modification method and application thereof. The application utilizes a biological source catecholamine compound with redox activity (a characteristic structure unit can realize reversible conversion between phenol and quinone, and can generate a semiquinone free radical through disproportionation reaction, that is, QH2+Q ⇌ 2SQ·) to perform coordination modification on a metal complex photosensitizer, so that a new type of high-efficiency stable photosensitizer can be constructed. The application simultaneously solves three core pain points of existing photosensitizers, that is, low efficiency, instability and insecurity, pushes the metal complex photosensitizer to a brand-new performance platform, and is extremely likely to become a key breakthrough for promoting clinical transformation and application of the photosensitizer.

A battery according to one embodiment may comprise: a case; and an electrode assembly which is disposed in the case and which includes a first electrode, a second electrode having a polarity different from that of the first electrode, and a separator disposed between the first electrode and the second electrode. The separator can include: a base layer including pores; and a coating material applied onto the surface of the base layer, and penetrated into the pores so as to cover the inner surface of each of the pores. The coating material can include: a polymer material containing catecholamine; and ceramic particles, each having a size smaller than the pore size of each of the pores.

The present invention relates to new solid forms of the compound (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below.The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.

The utility model discloses a mass spectrometer for measuring tea phenolamine metabolite, which relates to the technical field of tea phenolamine metabolite detection, and comprises a mass spectrometer body and a lofting mechanism arranged at one end in the mass spectrometer body, and the lofting mechanism comprises a movable plate arranged at the bottom of one end in the mass spectrometer body. An electric cylinder is mounted on one side of the inner wall of the movable plate, a mounting seat is mounted on a piston rod of the electric cylinder, a servo motor is mounted on the inner wall of the top of the mounting seat, an output shaft of the servo motor is sleeved with a placement plate, and a plurality of placement grooves are formed in the inner wall of the top of the placement plate. The placing plate can extend out of the mass spectrometer body through the movement of the movable plate, the electric cylinder works to drive the mounting seat to move along the inner wall of the movable plate, and the placing plate can be driven to further move, so that a worker can conveniently place and replace a sample, and the working efficiency of the mass spectrometer can be improved.

The invention relates to the technical field of photonic crystals, in particular to a water-based photonic crystal chain and a preparation method and application thereof. The water-based photonic crystal chain has a core-shell structure, the core of the water-based photonic crystal chain comprises magnetic ferroferric oxide, and the shell layer of the water-based photonic crystal chain comprises polycatecholamine and a polyethyleneimine cross-linked compound; the magnetic ferroferric oxide is connected with the polycatecholamine and polyethyleneimine cross-linked compound through hydrogen-bond interaction. In a magnetic field, magnetic ferroferric oxide is used as a core, Fe (II) and Fe (III) on the surface of the magnetic ferroferric oxide are used as catalytic sites, ordered decomposition of hydrogen peroxide and oxidative auto-polymerization of catecholamine and polyethyleneimine are controlled, and a one-dimensional magnetic photonic crystal chain is obtained through ordered assembly. By optimizing the coating ratio of the magnetic ferroferric oxide to the polycatecholamine and polyethyleneimine cross-linked compound, the magnetic field intensity, the raw material reaction concentration and other conditions, the magnetochromic material with stable and sensitive structural color is obtained, and the obtained photonic crystal chain is expected to be widely applied to various application scenes such as color-changing ink.

The invention discloses a 96-hole preassembled plate catecholamine and metabolite pretreatment kit thereof, and belongs to the technical field of in-vitro diagnostic reagents. The kit comprises a preassembled plate, wherein magnetic bead suspension liquid, equilibrium liquid (acetonitrile, formic acid and water), leacheate 1 (acetonitrile and water), leacheate 2 (acetonitrile and water) and eluent (acetonitrile, formic acid and water) are loaded on the preassembled plate; wherein the magnetic bead suspension comprises absolute ethyl alcohol and magnetic beads; the magnetic bead takes FeO as an inner core, the surface of the magnetic bead is modified with a silicon-based carrier, a carboxyl-phenylboronic acid bifunctional group and a porous polymer, the magnetic bead can be specifically combined with catecholamine and metabolites thereof in human serum or plasma, efficient separation and release of a to-be-detected substance are achieved through a magnetic separation technology, and the magnetic bead is suitable for follow-up mass spectrum quantitative analysis. The kit disclosed by the invention has the characteristics of simplicity and convenience in operation, high extraction efficiency and good stability, the pretreatment time can be remarkably shortened, the detection accuracy is improved, and an efficient solution is provided for clinical detection of catecholamine and metabolites thereof.

The application discloses functionalized porous aluminum oxide ceramic microspheres, a preparation method and application, the ceramic microspheres take aluminum oxide as a main skeleton, and have a through multistage pore structure; and a chelating functional layer is fixed on the outer surface and / or pore inner wall of the ceramic microspheres.The application realizes synchronous construction of balling and pore structure by adopting a solvent-non-solvent exchange induced phase transfer method; multistage pore structure is obtained by adjusting polymer phase content, porogen molecular weight and a coagulation bath; strong adhesion to the surface of Al2O3 is realized by the combined modification of an adhesive primer layer+covalent / coordination immobilization+secondary capture layer, and catechol / amine active sites are provided for subsequent reactions; the ceramic microspheres have high adsorption capacity and selectivity for heavy metal ions in an aqueous solution, can be regenerated by pickling with dilute hydrochloric acid after adsorption saturation, realize cyclic use and heavy metal recovery, and have wide application prospects in the field of heavy metal wastewater treatment.

The invention relates to a diagnostic index for hypertension grading and application thereof, and belongs to the technical field of biology. By screening catecholamine and hormone metabolic profiles in blood plasma of hypertensive patients and analyzing the relationship between different hypertension grading and cardiovascular adverse events and catecholamine and hormone levels, the corticotin level can be used as a diagnostic index of hypertension grading. The invention breaks through the traditional few index detection limitation, comprehensively detects a series of catecholamines and metabolites thereof, covers novel and less concerned methylation or oxidation modified derivatives and the like, deeply captures metabolic pathway changes, finds a new metabolic biomarker corticosin, fills up the blank of metabolite detection, and provides more molecular basis for accurate diagnosis; a more accurate and comprehensive diagnosis method is established, and excessive diagnosis of the secondary hypertension and missed diagnosis of the secondary hypertension are reduced, so that a patient can obtain targeted treatment.

The application discloses a kind of efficient sealant for battery assembly and preparation method thereof, relating to sealant technical field, with composition total mass is 100 mass parts, including silane end-capped polyether prepolymer 20~24 parts, liquid epoxy resin 11~14 parts, alkoxy silane crosslinking agent 2.4~3.6 parts, latent epoxy curing agent 1.5~2.6 parts, composite coupling agent 1.2~2.0 parts, surface modified composite inorganic filler 18~23 parts, organic bismuth catalyst 0.06~0.15 parts, auxiliary agent 0.4~1.0 parts, the rest is silane end-capped polyether resin;Silane end-capped polyether prepolymer simultaneously contains catecholamine, polycaprolactone segment and alkoxy silane end-capped group;The sealant is synergized by moisture curing system and thermal curing system, has good initial setting capacity and late enhancement effect, while giving consideration to adhesion, flexibility, sag resistance and moisture resistance, electrolyte resistance, suitable for battery assembly sealing scene.