96 results about "Catecholamine" patented technology

The present invention provides compounds of formula (I) that are prodrugs of catecholamine for use in treatment of neurodegenerative diseases and disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating neurodegenerative or neuropsychiatric diseases and disorders using the compounds of the invention, in particular Parkinson's disease.Accordingly, the present invention relates to compounds of formula (Id)whereinR1 is H and R2 is selected from one of the substituents (i) and (ii) below; orR1 is selected from one of the substituents (i) and (ii) below and R2 is H; orR1 and R2 are both represented by substituent (i) below; orR1 and R2 are both represented by substituent (ii) below; orR1 is substituent (i) and R2 is substituent (ii); orR1 is substituent (ii) and R2 is substituent (i);wherein * indicates the attachment point; andwherein the carbon atom at the attachment point on substituent (i) is in the S-configuration; or a pharmaceutically acceptable salt thereof.

The invention relates to a new membrane for the separation of gas, vapor and liquid mixtures with a layer of optionally carbonized polymerized catecholamines, as well as methods for producing such membranes, and their use as a molecular sieve membrane.

The invention relates to a new membrane for the separation of gas mixtures, vapor mixtures and liquid mixtures, the membrane comprising a layer of thermally stabilized (preferably carbonized) polymerized catecholamines, and to methods for producing membranes of this type and the use thereof as molecular sieve membranes.

The present invention provides a kit and a detection method for synchronously detecting catecholamines and their metabolites, which relates to the technical field of analytical detection. The kit contains a diluent, a solid-phase extraction reagent, an LC-MS / MS detection reagent, a solid-phase extraction device, and a solid-phase extraction packing material. Among them, the solid-phase extraction packing material creatively adopts zwitterionic exchange microspheres containing both carboxyl and quaternary ammonium groups. The kit can not only synchronously and efficiently separate and detect 8 kinds of catecholamines and their metabolites in urine samples, but also separate and detect 6 kinds of amino-containing catecholamines and their metabolites in blood samples. When the above kit is used to separate and detect catecholamines and their metabolites, the extraction recovery rate is relatively high, and the linear range covers the reference value range of normal detection, which can significantly shorten the detection time of urine samples, improve the detection efficiency of mass spectrometry, and is conducive to popularization and application in clinical detection.

The invention discloses a detection method of catecholamine substances and metabolites thereof, freeze-dried powder and application of the freeze-dried powder. The detection method of catecholamine and metabolites thereof comprises the following step: detecting a sample to be detected by adopting a liquid chromatography-tandem mass spectrometry method. According to the present invention, the sample pretreatment and the detection condition optimization are performed so as to achieve the efficient and accurate detection of noradrenaline, epinephrine, variepinephrine, noradrenaline, dopamine and 3-methoxytyramine, the sensitivity is high, the specificity is good, and the new reliable detection method is provided for the detection of catecholamine and metabolites thereof in the blood sample.

The invention provides a kit for synchronously detecting catecholamine and metabolites thereof and a detection method, and relates to the technical field of analysis and detection. The kit comprises a diluent, a solid-phase extraction reagent, an LC-MS / MS detection reagent, a solid-phase extraction device and a solid-phase extraction filler. Wherein the solid-phase extraction filler creatively adopts an amphiphilic ion exchange microsphere containing two functional groups, namely carboxyl and quaternary ammonium at the same time. The kit can be used for synchronously and efficiently separating and detecting eight catecholamines and metabolites thereof in a urine sample; and 6 kinds of catecholamines containing amino groups and metabolites thereof in a blood sample can be separated and detected. When the kit is used for separating and detecting catecholamine and metabolites thereof, the extraction and recovery rate is high, the linear range covers the reference value range of normal detection, the detection time of a urine sample can be remarkably shortened, the detection efficiency of mass spectrum is improved, and popularization and application in clinical detection are facilitated.

The utility model discloses a catecholamine reagent packaging box which comprises an outer box body and a lining body. The lining body is of a three-layer structure which is a supporting layer, a second bracket layer and a third bracket layer. Limiting fixing holes are correspondingly formed in the third bracket layer and the second bracket layer, are distributed in a matrix form, and are divided into centrifugal tube limiting fixing holes and glass bottle limiting fixing holes. The outer box body is combined with the specially-designed lining body to package catechol reagents, and the catechol reagent packaging box has the advantages of being good in damping and dustproof effect; moreover, the centrifugal tube limiting and fixing holes in the lining body adopt different aperture design, and the glass bottle limiting holes adopt saw-toothed round hole design, so that the fixing effect is good, the reagent bottle is prevented from being damaged due to collision, the storage and transportation of the reagent are facilitated, and the safety is improved. The limiting fixing holes are distributed in a matrix manner, so that a user can take out conveniently without making mistakes, and the working efficiency is improved.

The present application is applicable to the field of medical devices, and discloses a liquid chromatography-mass spectrometry apparatus and a control method for the liquid chromatography-mass spectrometry apparatus. The liquid chromatography-mass spectrometry apparatus comprises a sample storage device, a pretreatment device, a chromatography device, a mass spectrometry detection device, and a controller. The chromatography device comprises a test solution preparation channel, a test solution transfer assembly, a liquid phase fluid delivery assembly, and a chromatography column. An operating pressure outputted by the liquid phase fluid delivery assembly is less than or equal to 20 MPa. The length of the chromatography column is greater than or equal to 3 mm and less than or equal to 35 mm. A sample comprises a target substance to be measured, and the target substance to be measured comprises at least one of vitamin D, a steroid hormone, and a catecholamine. The present application reduces costs of the liquid chromatography-mass spectrometry apparatus.

The present invention provides compounds of formula (I) that are prodrugs of catecholamine for use in treatment of neurodegenerative diseases and disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating neurodegenerative or neuropsychiatric diseases and disorders using the compounds of the invention, in particular Parkinson's disease.Accordingly, the present invention relates to compounds of formula (Id)whereinR1 is H and R2 is selected from one of the substituents (i) and (ii) below; orR1 is selected from one of the substituents (i) and (ii) below and R2 is H; orR1 and R2 are both represented by substituent (i) below; orR1 and R2 are both represented by substituent (ii) below; orR1 is substituent (i) and R2 is substituent (ii); orR1 is substituent (ii) and R2 is substituent (i);wherein * indicates the attachment point; andwherein the carbon atom at the attachment point on substituent (i) is in the S-configuration;or a pharmaceutically acceptable salt thereof.

To provide a device, system, and method for neuromodulation of nerves adjacent to the splenic artery, specifically for stimulating neural activity in the nerves.SOLUTION: A system 50 for stimulating neural activity of the splenic artery nerves includes: at least one electrode 11, 12 for making signal-transmitting contact with the nerves at a site where the splenic artery does not directly contact the pancreas; and at least one controller 60 electrically coupled to the at least one electrode and configured to control the operation of the at least one electrode to apply electrical signals to the nerves. The electrical signals result in improvements in physiological parameters in a subject, and include one or more from the group consisting of a reduction in inflammatory cytokines, an increase in anti-inflammatory cytokines, an increase in catecholamines, changes in immune cell populations, changes in immune cell surface co-stimulatory molecules, a reduction in factors involved in inflammatory cascades, changes in levels of immune response mediators, and a reduction in splenic blood flow.SELECTED DRAWING: Figure 1

The present invention provides sulfamate derivative prodrugs of the dopamine agonist (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol, their use in treating conditions for which treatment with a dopamine agonist has therapeutic benefit, and pharmaceutical compositions comprising a compound of the present invention. The compounds according to the present invention have the formula (Id), wherein R1and R2are each independently selected from H and the substituent (iii) below, wherein * indicates the point of attachment to oxygen, wherein R3is selected from H and COR4, and wherein R4is selected from H and C1-C6alkyl, with the proviso that R1and R2cannot both be H, 15or a pharmaceutically acceptable salt thereof.

The invention relates to the technical field of zinc ion batteries, and particularly discloses a zinc negative electrode protective film constructed by an in-situ inorganic hybrid polymer as well as a preparation method and application of the zinc negative electrode protective film. The preparation method comprises the following steps: dissolving a high-molecular polymer to form a solution, adding a catecholamine compound and an inorganic metal salt solution into the solution to obtain a membrane casting solution, uniformly coating a zinc plate with the membrane casting solution, and removing a solvent. According to the invention, dopamine rich in catechol groups is introduced on the polymer by using inorganic metal ions, so that zinc ions can be induced to be uniformly deposited; meanwhile, dopamine hydrochloride and inorganic metal ions improve the surface effect of the polymer in the polymerization process, the overpotential of zinc ion deposition is reduced, and generation and growth of zinc dendrites are further inhibited. The modified electrode has super-long cycle stability and good capacity retention rate when being used for the water-based zinc ion battery, and a new strategy is provided for further improving energy storage and prolonging the service life of the zinc ion battery.

The invention discloses a catecholamine substance multicolor visual detection kit and detection method based on synergistic catalytic reaction induction, and the method comprises the following steps: firstly, enabling catecholamine and AgNPLs to be subjected to a sufficient chemical adsorption reaction, and then adding hydrogen peroxide, so that the Ag NPLs are etched to different degrees and show different colors. According to the reaction of silver ions and urease and the cascade urease catalytic reaction, the color of pH indicator phenol red is changed, so that the colors of Ag NPLs and phenol red are compounded, the color recognition degree after the etching reaction is enhanced, and catecholamine substances are detected according to different colors. The method is simple, convenient, efficient, sensitive and high in naked eye recognition degree, and can be used for detecting diseases such as depression.

The present invention relates to a vanillic acid derivative compound which can be formed by a dehydration condensation reaction between vanillic acid and catecholamine. The vanillic acid derivative compound according to the present invention is characterized in that it can be used as a therapeutic preparation for Alzheimer's disease and neuroinflammation. In addition, the present invention relates to a therapeutic composition for Alzheimer's disease and a therapeutic composition for neuroinflammation, each of which comprises the compound.

Provided herein are methods and materials for preventing cytokine release syndrome (CRS). For example, methods and materials for using one or more catecholamine inhibitors to prevent a mammal from developing CRS are provided.

The present invention discloses a photothermal active starch-based food label and its preparation method, belonging to the technical field of packaging material processing. The method of the present invention is a preparation method of nanoparticles based on the in-situ self-polymerization of catecholamine-like substances and the coordination reaction of metal polyphenols. Under the action of the graphene π-π conjugation platform, the catecholamine-like substances are promoted to undergo in-situ self-polymerization with metal salts at the graphene interface to form a double-spherical metal polyphenol nanoparticle complex. At the same time, with the help of the amino-hydroxy interaction, the cyclodextrin cavity is adsorbed on the modified graphene interface. This cavity can adsorb fat-soluble volatile plant essential oils. The nanoparticles are dispersed in the starch-based film, and the starch-based film is complete and continuous. Under near-infrared light irradiation, it can be heated from 20°C to 200°C within 30 seconds, and the mechanical tensile strength reaches 28 MPa. It has excellent photothermal conversion performance and antibacterial performance, and can be used in the fields of food, medicine, medical devices, and agricultural product packaging.

The purpose of the present disclosure is to provide a novel plant environmental stress alleviator, a plant growth promoter, and a plant DNA repair promoter that have an excellent effect of alleviating environmental stresses such as high temperatures.　The present disclosure provides a plant environmental stress alleviator, a plant growth promoter, and a plant DNA repair promoter containing: one or more neurotransmitters selected from choline esters, catecholamines, serotonin, and amino acids, and / or one or more acetylcholinesterase inhibitors selected from polyphenols, flavonoids, and organic acids, or a plant extract containing said inhibitors; and calcium ions. The present disclosure also provides a method for producing the aforementioned agents.

The present invention provides prodrugs as catecholamines for use in the treatment of neurodegenerative diseases and disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention, and uses of the compounds of the invention in the preparation of treatment of neurodegenerative or neuropsychiatric diseases and disorders, especially Parkinson's disease.

The invention discloses prevention and treatment of diseases by stimulating TRPV1 + sensory nerves. Specifically, the invention discloses application of a substance for stimulating TRPV1 + sensory nerves in preparation of products for prevention, treatment or adjuvant treatment of inflammatory diseases, autonomic nerve dysfunction diseases or adrenal insufficiency diseases, and application of the substance for stimulating TRPV1 + sensory nerves in preparation of products for inhibiting proinflammatory cytokines and products for promoting anti-inflammatory cytokines. The TRPV1 ion channel agonist disclosed by the invention can obviously and effectively inhibit the expression of numerous proinflammatory cytokines and obviously improve the expression of anti-inflammatory cytokines IL10, so that not only is the physiological status of an inflammatory mouse obviously improved, but also the survival rate of the inflammatory mouse is obviously improved; meanwhile, the spleen function can be adjusted, expression of spleen pro-inflammatory genes is remarkably inhibited, generation of catecholamine is increased, and secretion of cortisol hormones is promoted. The invention has wide clinical application value in prevention and treatment of related diseases.

The application discloses a method and a kit for detecting catecholamine and its metabolites in urine, and comprises the following steps: adding an internal standard working solution to a urine sample to be detected, mixing, then adding butyric anhydride solution, mixing, and then oscillating and mixing at 20-35 DEG C for 5-30 min to perform a derivatization reaction; after the derivatization reaction is completed, centrifugation is performed, the supernatant is taken, and liquid chromatography tandem mass spectrometry is used for detection. The toxicity and danger of butyric anhydride are low, the by-product after derivatization is only butyric acid, and the by-product does not interfere with catecholamine substance detection, and a neutral or weakly alkaline environment with a pH of 7.0-8.0 can meet the derivatization conditions. Since the pretreatment time is short, and the structure is changed after derivatization, the stability of catecholamine prototype substances is improved, meanwhile, the structure after derivatization is more easily ionized in a mass spectrometry ion source, the substance response intensity is also increased, and the detection result is more reliable.

To provide a solid form of a compound useful as a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.SOLUTION: Provided is a solid form of the compound of formula (Id), where the solid form is selected from a) a zwitterion form, b) an alkali metal salt and c) a halogen salt.SELECTED DRAWING: None

The invention relates to the technical field of catecholamine detection, in particular to a copper-doped carbon dot with similar catechol oxidase activity as well as a preparation method and application of the copper-doped carbon dot. The copper-doped carbon dot provided by the invention can be used as a nano-enzyme for specific catalytic oxidation of catecholamine, so that catecholamine is detected by a colorimetric method. Copper atoms in the copper-doped carbon dots are dispersed in a monatomic form, and a local coordination structure is Cu-N3O which is similar to metal active sites in natural enzyme; according to the structure, the electron transfer capability and the redox activity of a Cu center are remarkably enhanced, so that the structure shows efficient catalytic activity and substrate specificity in a catecholamine oxidation reaction.

The invention relates to the technical field of analysis and detection, in particular to a kit and a method for extracting catecholamine and metabolites thereof based on a paramagnetic particle method and a method for detecting catecholamine and metabolites thereof by LC-MS / MS (liquid chromatography-mass spectrometry / mass spectrometry). The kit comprises magnetic beads, an activating solution, an eluent, a washing solution, a leacheate I, a leacheate II and a derivatization reagent, the catecholamine and the metabolite thereof comprise one or more of dopamine hydrochloride, epinephrine, noradrenaline hydrochloride, methoxynoradrenaline hydrochloride, methoxyepinephrine hydrochloride and 3-methoxytyramine hydrochloride. The in-vivo concentration of catecholamine and metabolites thereof in human plasma and urine is detected in a high-flux manner by adopting a magnetic bead and derivation method, and the kit has the characteristics of high sensitivity, good repeatability, high accuracy, good specificity and the like.

The present invention provides compounds of formula (I) that are prodrugs of catecholamine for use in treatment of neurodegenerative diseases and disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating neurodegenerative or neuropsychiatric diseases and disorders using the compounds of the invention, in particular Parkinson's disease. Accordingly, the present invention relates to compounds of formula (Id) wherein R1 is H and R2 is selected from one of the substituents (i) and (ii) below; or R1 is selected from one of the substituents (i) and (ii) below and R2 is H; or R1 and R2 are both represented by substituent (i) below; or R1 and R2 are both represented by substituent (ii) below; or R1 is substituent (i) and R2 is substituent (ii); or R1 is substituent (ii) and R2 is substituent (i); wherein * indicates the attachment point; and wherein the carbon atom at the attachment point on substituent (i) is in the S-configuration; or a pharmaceutically acceptable salt thereof.

The invention discloses a stain-resistant glazed travertine porcelain tile and a preparation method thereof, and relates to the technical field of ceramic tiles, and the glazed travertine porcelain tile comprises a substrate layer, a travertine decorative layer and a glaze layer which are sequentially stacked from bottom to top; the upper surface of the travertine decorative layer is treated by a modification process; the thickness of the travertine decorative layer is 25%-30% of that of the substrate layer, a modification solution is adopted in the modification technology, and the modification solution is formed by mixing catecholamine and a tris (hydroxymethyl) aminomethane solution according to the weight-volume ratio of 1 kg: 200 L. Compared with the prior art, the preparation method has the advantages that the surface of the travertine porcelain tile blank obtained through one-time firing is modified, catecholamine is subjected to an oxidation self-polymerization reaction in a wet state, the compactness of the surface of the travertine porcelain tile is increased, the glaze surface of the final porcelain tile is kept flat and dense at microscopic holes on the basis that macroscopic decorative holes are reserved, and the quality of the travertine porcelain tile is improved. Further, the anti-pollution capability of the surface of the travertine porcelain tile is effectively improved.

The invention provides a magnetic bead extraction unit, a magnetic bead extraction system and application of the magnetic bead extraction unit in catecholamine pre-packaging extraction, and designs the magnetic bead extraction unit which is pre-filled with a magnetic bead treatment reagent of a single sample and can be used for completing magnetic bead extraction before mass spectrometry of the single sample; according to the number of samples needing to be detected, a corresponding number of magnetic bead extraction units are selected and placed on the test tube rack, so that a magnetic bead extraction instrument can be matched to complete magnetic bead extraction of the required number of samples; a pre-packaging kit for extracting catecholamine in a sample is designed, and a magnetic bead activating agent, a washing solution and an eluent which are not easy to volatilize and higher in stability are screened. The magnetic bead extraction unit is simple in structure and convenient to use, the problem of waste of magnetic bead treatment reagents is avoided, the magnetic bead treatment process is more flexible and efficient, the pre-subpackaged reagents are stable in performance, not prone to volatilization and long in quality guarantee period, and the magnetic bead extraction unit is suitable for large-scale application and popularization.

Provided is stimulation of TRPV1+ and / or TRPA1+ sensory nerves for the prevention and treatment of diseases. Particularly provided is use of a substance for stimulating TRPV1+ and / or TRPA1+ sensory nerves in the prevention or treatment of inflammatory diseases, dysautonomia, or adrenal insufficiency, and in inhibiting the generation of pro-inflammatory cytokines and promoting the generation of anti-inflammatory cytokines. A TRPV1 and / or TRPA1 ion channel agonist can significantly effectively inhibit the expression of numerous pro-inflammatory cytokines and significantly improve the expression of the anti-inflammatory cytokine IL10, significantly improving both the physiological state and the survival rate of mice with inflammation. Moreover, the agonist can adjust spleen function, significantly inhibit the expression of pro-inflammatory genes in the spleen, increase the generation of catecholamine, and promote the secretion of cortisol-like hormones. The agonist has wide clinical application value for the prevention and treatment of related diseases.

A kind of melanin and its preparation method, which relates to the field of functional materials. The melanin mainly consists of three types of components, namely A, B, and C. Among them, component A is dihydroxyacetone; component B is one or more mixtures selected from 3-hydroxy-L-tyrosine, lysine, glycine, histidine, methionine, arginine, cystine, cysteine, tyrosine, acetyltyrosine, proline, amidinoprolin, hydroxyproline, phenylalanine; component C is one or more mixtures selected from dopamine hydrochloride, caffeic acid, chlorogenic acid, ellagic acid, gallic acid, protocatechuic acid, honeysuckle extract, dihydroxyindole, octanoyl epicatechin gallate, epigallocatechin galloyl glucoside, epigallocatechin gallate, catechol gum, catecholamine, catechu leaves / wood powder, uncaria rhynchophylla extract. The present invention can obtain natural and safe synthetic melanin, and the reaction time is short, and the synthesis process is safe and simple.