204 results about "Catecholamine" patented technology

An implantable medical device is provided for the treatment of a variety of disorders. The implantable medical device can be a neurostimulator having a stimulation lead and electrode(s) configured to be implanted on or near neural tissue in communication with the adrenal gland. Application of an electrical waveform to the neural tissue can cause the adrenal gland to release catecholamines to treat hypoglycemia. In other embodiments, chemical, magnetic, optical, or mechanical neuromodulation can be used.

Compositions and methods are provided for obtaining stabilized quinol compositions, such as catecholamine drugs (e.g., epinephrine solutions), and also for obtaining stable pharmaceutical formulations that comprise a stabilized quinol composition and a second pharmacologically active component such as a local anesthetic or other active drug ingredient having a reversibly protonated amine group. Stability is achieved through the inclusion of an appropriately selected pH buffer and a thiol agent, based on redox and pH buffering principles including pKa of the buffer and of the reversibly protonated amine group.

The invention discloses a preparation method for a carbon nano tube composite film. The method comprises the following steps: first, allowing a phenolic hydroxyl group, a quinonyl group and other functional groups to be introduced on the surface of a carbon nano tube through oxidation autopolymerization reaction of catecholamine under an alkalescence condition, so as to realize the modification for the surface of the carbon nano tube; then, using water-soluble polymers with amino groups or mercapto groups as raw materials to realize layer-by-layer self-assembly under the action of chemical bonds formed by Schiff base or Michael Addition reaction, thereby obtaining the carbon nano tube composite film. The method has the advantages of mild reaction condition, environmental protection, simplicity and feasibility, and is suitable for industrialized production. The carbon nano tube composite film prepared by the method has the advantages of excellent thermal and chemical stability, ductility, mechanical strength and transparency.

A method of treating neurotransmitter dysfunction in a patient. The method includes the step of administering an amino acid precursor of a catecholamine in a balanced and effective therapeutic range. The catecholamine precursor is preferably L-dopa, but may alternatively be tyrosine, D,L-Phenylalanine or an active isomer thereof, and N-acetyl-L-tyrosine or other amino acid precursor of L-dopa. An amino acid precursor of serotonin in an effective therapeutic range, is also administered. The serotonin precursor is preferably 5-HTP, but may alternatively be tryptophan. At least one cofactor is also preferably administered. Cofactor options include Vitamin B6, Vitamin C, Calcium, Folate, and Cysteine. A method of periodic administration and patient checking is also disclosed.

Hibernating myocardium is characterized by viable myocardium with impaired function due to localized reduced perfusion. Hibernating myocytes retain cellular integrity, but cannot sustain high-energy requirements of contraction. High plasma levels of catecholamines, such as norepinepherine, are believed to be predictive of mortality from hibernating myocardium. Likewise, high levels of catecholamines lead to cardiomyopathy in patients with diabetes. GLP-1 reduces plasma norepinepherine levels, and it thus is useful in a method of treating hibernating myocardium or diabetic cardiomyopathy.

The invention discloses a method for detecting catecholamine in blood plasma by liquid chromatography tandem mass spectrometry. The method comprises the following steps of preparing a standard product, separating by liquid chromatography, detecting by a mass spectrum, drawing a standard curve, and detecting the catecholamine in the blood plasma. The method has the beneficial effects that the catecholamine is detected by innovatively applying a high-flux liquid chromatography tandem triple quadrupole mass spectrograph; protein is precipitated by acetonitrile, dansyl chloride is used for performing derivative reaction, and the liquid chromatography tandem triple quadrupole mass spectrograph is used for detecting after extraction, so that the pretreatment steps are simple, the interference of a matrix in the blood plasma is effectively removed, and the specificity is good; after the derivatization of dansyl chloride, the detection sensitivity is effectively improved; the high-flux liquid chromatography tandem rod mass spectrograph is used for detecting, three types of catecholamine, including dopamine, epinephrine and norepinephrine, in the blood plasma can be quantitatively and accurately detected; the detection time is short, the flux is high, the detection sensitivity is high, the specificity is good, and the cost is low.

The invention discloses a method for detecting catecholamine and metabolites by using liquid chromatography-tandem mass spectrometry technology. The method can be used for one-time detection of catecholamine and metabolites thereof with high sensitivity and specificity. The method can be used for detecting MN and NMN (indices which are firstly recommended in an association guide), E and NE (effects for auxiliary diagnosis) as well as DA and 3-MT, and the method can be used for carrying out diagnosis of PPGL of various types with very high sensitivity and specificity, wherein the sensitivity and the specificity respectively reach 100% and 97.2%.

The present invention relates to novel catecholamine derivatives of Formula I, to processes for their preparation, pharmaceutical compositions containing them and to their use in therapy.

The invention relates to a preparation method of a polymer flooding produced fluid demulsifier. The method comprises the following steps: by using multiramiform tetraphenol ethane catecholamine resin as an initiator, polymerizing with propylene oxide to obtain a demulsifier oleophylic head, and polymerizing the demulsifier oleophylic head with epoxyethane to obtain the multiramiform polyether demulsifier. The demulsifier can be used for efficiently and quickly demulsifying crude oil and especially thick oil. The method solves the problems of low dehydration rate, low dehydration speed and the like in the polymer flooding produced fluid in the prior art, satisfies the harsher requirements for time and dehydration rate of the demulsifier by the offshore platform, and can be used for demulsifying and dehydrating an offshore polymer flooding produced fluid.

The invention discloses a detection method for high throughput liquid chromatogram tandem mass spectrum. The method comprises the following steps: (S1) preparing a sample; (S2) performing derivatization reaction; (S3) pretreating the sample; (S4) separating the liquid chromatogram; and (S5) detecting the tandem mass spectrum. Besides, the invention also discloses a method for detecting four catecholamine metabolites through a high throughput liquid chromatogram tandem mass spectrometry. The detection method provided by the invention is fit for the detection for the catecholamine metabolites in human plasma and has the advantages of simple sample pretreatment, capability of simultaneously detecting four catecholamine metabolites, excellent detection specificity, short time in the whole detection process and high throughput.

The invention discloses a multi-branch structure demulsifier of an aromatic ring core. The demulsifier is prepared by the following processes of alternatively carrying out Michael addition and amidation condensation reaction in a methanol solvent by using two materials of methyl acrylate and a polyamine substance on the basis of the structure of catecholamine resin prepared from aromatic ring phenol, ethanediamine and formaldehyde in a condensation manner; grafting a repetition structure unit of polyamide-polyamidoaminedendrimer (Dendrimer) on the catecholamine resin, and synthesizing a Dendrimer macromolecule of a super-multi-branch aromatic ring core as an initiator; grafting a polyether chain segment by oxyalkylation reaction of a functional group of the Dendrimer macromolecule initiator; regulating and controlling the structure and the ratio of the polyether chain segment, so as to prepare a series of polyether demulsifiers with novel structures.

The present invention relates to a method for preparing a double-sided film containing the step of forming a film in the interface between air and the mixture of a polymer comprising amine group (—NH) and a compound containing phenol or catechol by exposing the mixture on the air. Particularly, the double-sided film of the present invention is a separation membrane that can separate the interface of liquid phase and gas phase and at the same time can be used as a biomaterial such as a haemostatic and also an waterproof agent. When the film is prepared in a moderate condition by using an enzyme, the film can include proteins and cells, resulting in the multi-functional versatility film that can be useful as a biocatalyst. The versatility film of the present invention, thus, is not expensive and the production method thereof is simple and eco-friendly. Therefore, the film of the invention has a high added-value as a novel separation membrane that can replace the conventional separation membrane.

The invention belongs to the technical field of inorganic materials and analysis and particularly relates to a simple preparation method for formylphenylboronic acid modified magnetic nanoparticles (Fe3O4@PEI-FPBA) and application of the formylphenylboronic acid modified magnetic nanoparticles in selective enrichment of catecholamines in urine. Magnetic microspheres Fe3O4@PEI are synthesized by a one-pot method and then are grafted with phenylboronic acid functional groups through reductive amination reaction so as to form the hybridized magnetic nanoparticles. The magnetic material has the characteristics of simple preparation method, high adsorption capacity, good selectivity and short balancing time; and when the magnetic material is applied to the selective enrichment of a trace amount of catecholamines in the urine, the pretreatment process is simple and rapid and is high in specificity. The material has an excellent application prospect in the enrichment of a 1,2-cis-dihydroxy compound in body fluids.

The invention relates to the technical field of materials, and provides an amine-rich catecholamine compound and a preparation method thereof. The amine-rich catecholamine compound is prepared by thereaction of a carboxyl-containing plant polyphenol compound and an amine-rich molecule. The invention also provided a catecholamine-based amine-rich surface-modified product, including an alkaline buffer solution and the amine-rich catecholamine compound, and the ratio of the amine-rich catecholamine compound to the alkaline buffer solution is 0.01-100 mg: 1 mL. The amine-rich catecholamine compound is prepared by the reaction of the carboxyl-containing plant polyphenol compound and the amine-rich molecule. A coating formed by the surface-modified product has good wide-spectrum adhesion properties and stable chemical properties under strong acid and strong base conditions, and the surface-modified product can further react with various functional compounds to impart new properties to the coating. A material with the coating on the surface of the material and a method of dip-coating the catecholamine-based amine-rich coating on the surface of the material are also provided.

This invention relates to compositions which enhance a mammal's immune response to a cytokine by administering therapeutic amounts of catalysts for the dismutation of superoxide which include superoxide dismutase enzyme (SOD) and small molecular weight organic ligand mimics of that enzyme (SOD mimetics or SODms), alone or in combination with a cytokine. These compositions may be used in methods for enhancing a mammal's immune response to a virus such as the hepatitis C virus or the human immunodeficiency virus (HIV) or to a tumor thereby inhibiting the proliferation of the tumor. Relatedly, these compositions may be used in methods of treating mammals infected with HIV or mammals suffering from Hepatitis C or AIDS. This invention also relates to methods of enhancing cancer therapy and methods of preventing and treating hypotension in a mammal resulting from the administration of cytokines by the administration of therapeutic amounts of catalysts for the dismutation of superoxide in combination with a cytokine and catecholamine pressor agents. Also provided are pharmaceutical compositions comprising catalysts for the dismutation of superoxide alone or in combination with cytokines and catecholamine pressor agents for use in the above methods.

A composition for local anesthesia which comprises a local anesthetic such as lidocaine hydrochloride as an active ingredient and an agent for sustaining anesthetic action selected from the group consisting of antihistamines such as diphenhydramine hydrochloride or hydroxyzine hydrochloride, and does not substantially contain catecholamines such as epinephrine, which has increased durability of anesthetic action without using catecholamines, and is useful as a safe composition for local anesthesia for performing short-time dental operations such as tooth extraction or oral surgery operations.

A sensor for the detection of chemical messengers is described herein. In particular a sensor for the detection of catecholamines, for example dopamine, epinephrine or norepinephrine, is reported. Catecholamines play pivotal roles as neurotransmitters and hormones in the human body. An electrode for detecting a catecholamine comprising a conducting or semi-conducting substrate, and a polymer comprising polyethylenedioxythiophene on said substrate is disclosed. The polymer is doped with a cyclodextrin macrocycle. Suitable cyclodextrin macrocycles include anionic cyclodextrin macrocycles, for example sulfonated β-cyclodextrins (CDs). Also, disclosed in sensor capable of selectively detecting a catecholamine in the presence of ascorbic acid (ascorbate).

The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 65 mm Hg or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm Hg to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.