427 results about "Formate" patented technology

The invention belongs to the technical field of catalysts, and particularly relates to a supported catalyst as well as a preparation method and application thereof. The preparation method of the supported catalyst provided by the invention comprises the following steps: mixing soluble transition metal salt, a carrier, an alkaline aqueous solution and water, and dipping to obtain a primary catalyst; the soluble transition metal salt comprises transition metal oxalate, transition metal formate or transition metal citrate; and carrying out microwave roasting on the primary catalyst to obtain the supported catalyst. According to the method, the transition metal salt is used as a roasting precursor, the transition metal is subjected to in-situ reduction in the reducing atmosphere generated during thermal decomposition of the transition metal salt in the roasting process, roasting and reduction are completed through microwave roasting one-step heating, the preparation steps are simplified, and meanwhile energy consumption is reduced. The supported catalyst is used in a catalytic condensation coupling hydrogen transfer reaction, has high conversion rate and coupling product selectivity, and can stably operate for a long time.

A method of increasing delivery of irrigation water and optionally a fertilizer to a predetermined depth in soil containing agricultural crops is disclosed. The method includes introducing formic acid to irrigation water to form a formate-enhanced irrigation water having a formate concentration of from about 10 ppm to about 10,000 ppm, and distributing the formate-enhanced irrigation water to the soil in an amount sufficient to (i) increase a flow rate of the irrigation water through the soil, (ii) reduce a compaction of the soil, and / or (iii) reduce a calcium concentration in the soil.

The invention discloses a synthesis method of 2-bromomethyl-5-trifluoromethyl furan, which comprises the following steps: S1, carrying out reaction on acetoacetate and halogenated trifluoroacetone under the action of an alkaline substance and a catalyst to generate a 2-acetyl-5, 5, 5-trifluoro-4-oxovalerate crude product; s2, carrying out a cyclization reaction on the 2-acetyl-5, 5, 5-trifluoro-4-oxovalerate crude product, so as to obtain a 2-methyl-5-(trifluoromethyl) furan-3-formate crude product, and carrying out a cyclization reaction on the 2-acetyl-5, 5, 5-trifluoro-4-oxovalerate crude product to obtain a 2-methyl-5-(trifluoromethyl) furan-3-formate crude product; s3, adding an alkaline substance into the crude product, carrying out hydrolysis, and adding acid to adjust the pH value after the hydrolysis is completed, so as to obtain 2-methyl-5-(trifluoromethyl) furan-3-formic acid; s4, the 2-methyl-5-(trifluoromethyl) furan-3-formic acid is subjected to a heating decarboxylation reaction, and 2-methyl-5-(trifluoromethyl) furan is obtained; and S5, carrying out a bromination reaction on the 2-methyl-5-(trifluoromethyl) furan and a bromination reagent to obtain a final product 2-bromomethyl-5-(trifluoromethyl) furan. The raw materials used in the synthesis method are easy to obtain, use of control chemicals is not involved, and industrialization is easy to achieve.

The present invention is to provide a method for producing a peptide containing an N-alkylamino acid, which comprises the following Steps (1) to (3). Step (1): a step of mixing an N-terminal protected amino acid or an N-terminal protected peptide with a carboxylic acid halide or a halogenated alkyl formate; Step (2): a step of mixing an amino acid or a peptide in which the N-terminal and the C-terminal are not protected with a trialkylsilylating agent; and Step (3): a step of mixing the product obtained in Step (1) with the product obtained in Step (2).

The invention provides a silver paste composition and a preparation method and application thereof. The silver paste composition comprises the following components in parts by weight: 80-120 parts of silver-containing filler, 20-40 parts of an organic solvent, 5-15 parts of a non-noble metal auxiliary agent with an atomic number of 24-30, 8-10 parts of a peroxide organic auxiliary agent and 1-5 parts of a rheological agent, the silver-containing filler comprises elemental silver powder and a silver-containing compound, and the weight ratio of the elemental silver powder to the silver-containing compound is (18-20): 1; the elemental silver powder comprises micron-scale silver powder and nano-scale silver powder; the silver-containing compound is selected from one or more of silver carbonate, silver lactate, silver formate, silver citrate and silver oxide. According to the low-temperature pressure sintered silver paste composition, low-temperature and low-pressure sintering of the silver paste composition is achieved by adding nano-scale and micron-scale silver powder, a metal precursor, a non-noble metal auxiliary agent and the like.

The invention belongs to the field of fertilizers, and particularly relates to a foliar fertilizer with high amino acid synthesis efficiency and a preparation method thereof.The preparation method comprises the steps that spermidine is taken to be subjected to formic acid esterification modification, and formic acid esterification spermidine is obtained; the preparation method comprises the following steps: hydrolyzing 2, 4-epibrassinolide to obtain carboxylated brassinolide; under the action of Tween, carboxylated brassinolide and formic acid esterified spermidine are combined to form a fertilizer base full of emulsified liquid drops; and adding other nutrients to obtain the foliar fertilizer. The leaf fertilizer for increasing the amino acid content of rice can increase the content of amino acids, especially lysine, in grains on the premise of increasing the yield of rice, and nitrogen absorption and utilization of the rice grains are improved.

The invention relates to low-temperature lead-free formic acid solder paste and a preparation method and application thereof, and belongs to the technical field of welding materials. The low-temperature lead-free formic acid solder paste is prepared from the following raw materials in percentage by mass: 85-90% of alloy welding powder and 10-15% of scaling powder, the soldering flux comprises the following raw materials in parts by weight: 10-15 parts of an activating agent, 1-5 parts of a rheological agent, 20-30 parts of an organic solvent, 20-30 parts of a paste forming agent, 3-5 parts of a surfactant and 0.1-0.5 part of a corrosion inhibitor, the activating agent is a composition of hydrogenated dimer acid, glycollic acid and ethylenediaminetetraacetic acid, and the organic solvent is a composition of tetrahydrofurfuryl alcohol and cyclohexanol. The paste forming agent is polyethylene glycol. The solder paste is suitable for a low-temperature welding process at the temperature of 120-150 DEG C, welding energy consumption can be reduced, the residual rate after welding is low, follow-up cleaning is not needed, the production environment can be improved, and the production cost can be reduced.

The invention discloses a method for biosynthesizing glyoxylic acid. According to the method, mutants (W86R, N87T, L109G, L110E, A460M, H281V and Q282F) of benzoyl formate decarboxylase (BFD) are used for condensing formaldehyde and carbon dioxide, and glyoxylic acid is generated through a reaction. Therefore, an artificial carbon sequestration way is provided, carbon dioxide can be converted into a two-carbon compound glyoxylic acid, the glyoxylic acid can enter a center for metabolism through a glyceric acid way, and theoretical support and technical basis are provided for construction of an artificial one-carbon cell factory and a new one-carbon resource biotransformation way. Meanwhile, glyoxylic acid is an important precursor for synthesizing glycine, so that a way for synthesizing glycine from carbon dioxide can be constructed based on the reaction of condensing carbon dioxide with formaldehyde, and a foundation is laid for conversion of carbon dioxide into a large amount of amino acid.

The present invention relates to the technical field of the preparation of electrocatalysts, and in particular relates to a bismuth-copper bimetallic composite catalyst, and a preparation method therefor and the use thereof. The catalyst comprises ultra-small copper nanoclusters and bismuth nanosheets, wherein the bismuth nanosheets are of a polycrystalline structure, and the copper nanoclusters are highly dispersed on the bismuth nanosheets; and the number of copper atoms in each copper nanocluster is less than 10. In the present invention, highly-dispersed ultra-small copper nanoclusters are loaded on bismuth nanosheets by means of the thermal decomposition of a metal complex and a subsequent in-situ electroreduction method, the electronic state of bismuth atoms is adjusted, and therefore the carbon dioxide activating capacity of the bismuth-copper bimetallic compound is improved, thereby achieving high-selectivity and high-activity preparation of a formate by means of the electrocatalytic reduction of carbon dioxide, and providing a new path for the efficient conversion of carbon dioxide. The bismuth-copper bimetallic composite catalyst provided by the present invention achieves both a formate selectivity of more than 90% and an ultrahigh activity under conditions of 1.2 A cm-2.

The invention relates to an SNCR (selective non-catalytic reduction) denitration synergist, a denitration composition and a denitration method. The SNCR denitration synergist comprises an organic solvent and alkali metal carboxylate, the mass ratio of the organic solvent to the alkali metal carboxylate is (0.1-1): 1, and the organic solvent is selected from one or more of alcohol, ketone, ether and aldehyde. The alkali metal carboxylate is selected from at least one of formate, acetate, citrate, oxalate, ascorbate and tartrate of alkali metal. According to the SNCR denitration synergist, the denitration efficiency can be remarkably improved in a medium and low temperature interval (600-800 DEG C), ammonia escape is reduced, and secondary pollution is reduced.

A direct electrolysis technology for a natural mineral wet mineralization CO2 capture stock solution belongs to the field of carbon capture and resource utilization, and is characterized in that CO2 is captured through natural mineral wet mineralization to generate a bicarbonate solution, an electrolytic bath is constructed by using a bismuth-based catalyst and a cation exchange membrane to directly electrolyze to generate formate, and the formate is directly electrolyzed to generate the CO2 capture stock solution. Formate and regenerated trapping liquid are separated through a bipolar membrane electrodialysis technology, slag can be converted into a silicon-based building material, and integration of emission reduction, value addition and circulation is achieved. Compared with a traditional amine trapping technology, the method has the advantages that the energy consumption is reduced by 40%-50%, the trapping liquid raw material cost is reduced by 60%-70%, the problems of solvent volatilization and equipment corrosion are avoided, and the method is suitable for distributed carbon trapping and resource conversion in high-emission industries such as steel and chemical engineering.

The invention relates to the field of carbon dioxide capture and utilization, in particular to a method and system for producing formate through synergistic capture and conversion of flue gas carbon dioxide, formate is obtained through electrochemical conversion of carbon-rich capture liquid, capture liquid is generated, the capture liquid directly captures flue gas carbon dioxide, and the carbon-rich capture liquid is obtained again. And the carbon-rich trapping liquid is continuously recycled for electrochemical conversion. The carbon-rich capture liquid electrochemical conversion process and the flue gas carbon dioxide capture process do not need to be alternately carried out step by step, but are synchronously and continuously carried out in the same system, the whole process does not need to pre-treat a small amount of oxygen and trace nitrogen oxide and sulfur oxide gas impurities in the flue gas, and a high-energy-consumption carbon dioxide gas regeneration step is avoided; the method overcomes the defect of low single conversion rate of electrochemical conversion of carbon dioxide gas, realizes collaborative capture and conversion of flue gas carbon dioxide to produce formate, and finally realizes direct conversion and utilization of carbon dioxide from flue gas to a high-value product formate.

The invention discloses an anti-bending data connecting line and a preparation method thereof, and relates to the technical field of data line preparation, polyethylene is coated on the surface of a conductor to form an insulating layer, a braid layer is arranged outside the insulating layer, a shielding layer is arranged outside the braid layer, and modified resin is coated outside the shielding layer to form a protective layer, so that the anti-bending data connecting line is prepared. The modified resin is prepared from the following raw materials: PVC paste resin, modified polyurethane, allyl alcohol glycidyl ether, dioctyl phthalate, trimethylolpropane trimethacrylate, a modified filler and 4, 4 '-diaminodiphenylmethane through banburying, the modified filler takes a carbon nanotube as a hard core, polyborosiloxane is coated as a soft layer, and the soft layer is coated with polyborosiloxane. The polymethyl methacrylate is of a special core-shell structure with a hard shell, when the polymethyl methacrylate is subjected to external force, a shell layer in the modified filler can promote cracks to deflect when reaching a core-shell interface, and the deflection of the cracks increases a crack propagation path, so that energy is absorbed, and the toughness of the modified resin is improved.

The invention discloses a preparation method of MOF (Metal Organic Framework) immobilized bi-enzyme, which is prepared from an organic ligand and zinc metal salt by a mild water-based method, and FDH (Friction Domain Hypoxia) and CA (Carbonic Acid) are immobilized in an embedding manner to form bi-enzyme cascade, so that the distance between enzymes is shortened, and the diffusion of substances in the reaction process is facilitated. The MOF immobilized bi-enzyme is used for enzyme electrocatalysis CO2 reduction, enzyme electrocatalysis NADH regeneration CO2 reduction is carried out on the MOF immobilized bi-enzyme and a PBS solution containing HNQ and NADH in a three-electrode H-type electrolytic tank composed of a cathode chamber, a proton exchange membrane and an anode chamber, the prepared MOF immobilized bi-enzyme is added into the cathode chamber, water is electrolyzed in the anode chamber to generate protons, the protons enter the cathode chamber through the proton exchange membrane, and the protons enter the anode chamber through the proton exchange membrane. Continuous regeneration of NADH is realized through reaction with NAD < + >, and the rate of cascade reaction is increased by combining substrate enrichment and NADH electrocatalytic regeneration. CO2 is efficiently captured by CA so as to enrich a substrate, and CO2 is efficiently reduced into formate in an enzyme electro-catalysis system in combination with electro-catalysis NADH regeneration.

The invention provides a photocuring composition and application thereof. The composition comprises the following components: (a) at least one benzoyl formate compound; (b) at least one ethylenically unsaturated photopolymerizable compound; the benzoyl formate compound is obtained by reacting a compound shown in a general formula (I) with a compound shown in a general formula (II) or a general formula (III), or is obtained by further reacting the compounds shown in the general formula (I), the general formula (II) and the general formula (III) with a compound with an end-capped substituent group for end capping. The sensitivity of the obtained product is not reduced compared with that of existing small molecules, and the hardness of the product is improved under LED curing.

The invention provides a Co (at) CeO2-x heterogeneous catalytic electrode as well as a preparation method and application thereof. The Co-coated CeO2-x heterogeneous catalytic electrode comprises foamed nickel and an electrocatalyst loaded on the surface of the foamed nickel, and the electrocatalyst comprises metal Co particles and CeO2-x with oxygen vacancy. The Co (at) CeO2-x heterogeneous catalytic electrode provided by the invention is prepared only through a process combining a room-temperature electrodeposition method and an air calcination method, has a three-dimensional self-supporting integrated structure, and also has a heterostructure and a porous nanosheet structure, so that more reaction active sites can be exposed, the interface charge transfer capability can be improved, and the catalytic performance can be improved. And the composite material has excellent activity and stability when being used as a cathode and an anode in the application of preparing formate and hydrogen by electrolyzing water under the assistance of glycerol.

The invention discloses a preparation method and application of a mesoporous anti-perovskite structure electrocatalyst for producing formate through electrooxidation of glucose, and belongs to the technical field of catalysts. The preparation method of the catalyst comprises the following steps: (1) dispersing Kit-6, copper nitrate and nickel nitrate in a mixed solution to obtain a solution 1; (2) incubating the solution 1 in a drying oven, and evaporating to dryness to obtain a powder precursor 1; (3) transferring the powder precursor 1 into a muffle furnace, and calcining to obtain a powder precursor 2; (4) adding the powder precursor 2 into sodium hydroxide, etching in a drying oven, washing and drying to obtain a powder precursor 3; and (5) transferring the powder precursor 3 into a tubular furnace, and calcining in an NH3 atmosphere to obtain the mesoporous anti-perovskite structure electrocatalyst. The catalyst prepared by the invention uses non-noble metal, so that the synthesis cost is reduced; the preparation process is simple. The catalyst is applied to production of formate through electrooxidation of glucose, and has the advantages of high catalytic stability, high formate yield and the like.

The invention relates to the technical field of materials, and discloses an antibacterial material containing modified 3-aminofuran-2-methyl formate and a preparation method thereof.The preparation method comprises the steps that modified 3-aminofuran-2-methyl formate, acrylic resin and talcum powder are extruded and granulated in a double-screw extruder, then granules are subjected to compression molding in a press vulcanizer, and the antibacterial material containing modified 3-aminofuran-2-methyl formate is obtained. The antibacterial material containing the modified 3-amino furan-2-methyl formate is obtained. Benzoxazine in the modified 3-aminofuran-2-methyl formate can form a heat-resistant phenolic resin structure at a high temperature, so that the modified 3-aminofuran-2-methyl formate has a relatively good flame-retardant effect; a three-dimensional network structure formed by boron-oxygen bonds contained in the flame retardant has high flame retardance of high oxygen index, low toxicity, low smoke and low calorific value; the carbon nano tube also has a relatively good flame-retardant effect; wherein the ferrocene group and the 3-aminofuran-2-methyl formate in the compound have a relatively good antibacterial effect.

The invention provides a device for extracting cesium from lepidolite and preparing cesium formate by a preparation system of cesium formate, which comprises: an extraction section, which comprises a plurality of first high-speed centrifugal extractors connected in series, and a first extraction inlet of the first high-speed centrifugal extractor of the last stage is introduced with a liquid to be extracted; the to-be-extracted liquid is leached frozen clear liquid of lepidolite, and the frozen clear liquid is alkaline and comprises cesium, rubidium, sodium, potassium and lithium ions; the t-BAMBP is diluted by adopting ESCAID 110 as an extraction agent, the concentration of the extraction agent is 0.4-0.6 mol / L of t-BAMBP, and the O / A ratio in the extraction section is 1: (1.8-2.0); the washing section comprises a plurality of second high-speed centrifugal extractors which are connected in series; the back extraction section comprises a third high-speed centrifugal extractor, and cesium bicarbonate back extraction post-liquid flows out of a first back extraction outlet of the third high-speed centrifugal extractor; the oil removal section is used for removing oil from the cesium bicarbonate back-extraction post-liquid; and the evaporation and concentration section is used for introducing formic acid for neutralization reaction to form a cesium formate solution after oil removal, and then evaporating and concentrating the cesium formate solution to obtain the final cesium formate solution.

The invention relates to a preparation method of 4-hydroxybutyl acrylate, which is characterized in that acrylic acid and tetrahydrofuran are used as raw materials, in the presence of a polymerization inhibitor and a compound catalyst, the 4-hydroxybutyl acrylate is prepared, the compound catalyst comprises concentrated sulfuric acid and metal salt, and the concentrated sulfuric acid and the metal salt are mixed to prepare the 4-hydroxybutyl acrylate. The metal salt is selected from one or more of ferric trichloride, ferric formate, ferric acetate, ferric acrylate, ferric methacrylate, chromium trichloride, chromium acrylate, chromium methacrylate, chromium acetylacetonate, ferric acetylacetonate, chromium picolinate, chromium formate and chromium acetate. According to the method disclosed by the invention, the 4-hydroxybutyl acrylate can be prepared with high selectivity under a mild condition.

Compositions and methods for a hybrid biological and chemical process that captures and converts carbon dioxide and / or other forms of inorganic carbon and / or CI carbon sources including but not limited to carbon monoxide, methane, methanol, formate, or formic acid, and / or mixtures containing CI chemicals including but not limited to various syngas compositions, into organic chemicals including biofuels or other valuable biomass, chemical, industrial, or pharmaceutical products are provided. The present invention, in certain embodiments, fixes inorganic carbon or CI carbon sources into longer carbon chain organic chemicals by utilizing microorganisms capable of performing the oxyhydrogen reaction and the autotrophic fixation of CO2 in one or more steps of the process.

The invention discloses a method for preparing formate through carbonate electroreduction and application of the formate. The method comprises the following steps: 1) assembling a three-electrode system by using an electrode loaded with a tin-based oxygen-containing compound as a working electrode, an Ag / AgCl electrode or Hg / HgO electrode as a reference electrode, a platinum electrode as a counter electrode and a carbonate solution as an electrolyte, and filling the electrolyte into a gas diffusion electrochemical reaction tank; and 2) introducing oxygen-containing gas into the gas diffusion electrochemical reaction tank, electrifying to sequentially carry out local reduction of the tin-based oxygen-containing compound, electroreduction of carbonate and regeneration of the tin-based oxygen-containing compound, and circulating in sequence. The method for preparing formate through carbonate electroreduction has the advantages of being easy to operate, simple in equipment, reliable in principle, low in cost, high in stability and the like, and is suitable for large-scale industrial application.

The invention relates to a chemically modified high-strength high-temperature-resistant polyurethane fiber and a preparation method thereof.The preparation method comprises the following steps that 1, oligomer mixed polyol and diisocyanate are subjected to a full prepolymerization reaction, a solvent is added for full dissolution, and a-NCO-terminated prepolymer polyurethane formate solution is obtained; 2) adding hydroxyalkyl silane and a catalyst into the prepared prepolymer, and fully reacting to obtain a modified prepolymer; (3) carrying out chain extension reaction and chain termination reaction on the prepared modified prepolymer to obtain a polyurethane urea solution; (4) adding an antioxidant, an ultraviolet light absorber, an anti-yellowing agent, a delustering agent and a lubricating and releasing agent into the polyurethane urea solution to prepare a polyurethane spinning solution; and (5) preparing the high-strength high-temperature-resistant polyurethane from the prepared polyurethane spinning solution by virtue of a dry spinning system. According to the invention, a polyurethane molecular chain is subjected to functional chemical modification, so that the product has the characteristics of high temperature resistance and high strength.

The invention belongs to the technical field of electrocatalytic carbon dioxide reduction, and particularly relates to a green and high-activity method for preparing formate through electrocatalytic carbon dioxide reduction. Comprising the following steps: loading a cathode catalyst on cathode carbon paper to obtain a catalytic cathode; loading an anode catalyst on the anode titanium felt to obtain a catalytic anode; constructing a flowing electrolytic tank by utilizing the catalytic cathode and the catalytic anode; carbon dioxide gas is introduced into the gas flow channel, so that the carbon dioxide gas is diffused to the catalytic cathode; an alkaline electrolyte is introduced into the liquid flow channel, so that the alkaline electrolyte flows through the catalytic anode; and voltage is applied to the flowing electrolytic tank for an electrolytic reaction, a product of the catalytic anode is collected, and formate is obtained after concentration and distillation. The method disclosed by the invention can be operated for a long time under the current density of 500-600mA / cm < 2 >, and the formate content in the formate solution can reach about 13%.

The invention discloses a citric acid coordination regulated amino-functionalized palladium-silver alloy catalyst as well as a preparation method and application thereof. Nitrogen-doped carbon is used as a carrier, and the palladium-silver alloy catalyst is constructed through coordination-confinement in-situ reduction of citric acid. According to the preparation method, citric acid is introduced, and synergistic interaction of sub-nano-scale dispersion and efficient interface mass transfer is achieved through dual synergistic regulation and control of the size and the interface; the coordination effect enables the palladium-silver alloy to achieve sub-nano-scale superfine dispersion; as a competitive hydrogen bond acceptor / donor, the polycarboxyl group can effectively break an interface hydrogen bond network and inhibit the formation of a tight gas film from the source. The mechanism ensures that the catalyst is always in full contact with a mixed aqueous solution containing formic acid and formate and hydrogen is quickly released during formic acid dehydrogenation hydrogen production reaction, so that the catalyst has excellent anti-poisoning cycling stability while keeping high intrinsic activity, and the technical problem that high activity and long-term stability are difficult to consider at the same time is solved.

The invention provides a grain boundary defect-enriched cerium dioxide nano catalyst and a preparation method thereof, and the preparation method comprises the following steps: preparing a cerium salt solution with nitrate radicals, reacting to obtain cerium formate and basic cerium carbonate precursor products, and washing, drying and roasting to obtain the grain boundary defect-enriched cerium dioxide nano catalyst. The cerium dioxide nano-catalyst prepared by the method can form an oxygen vacancy defect, promote the adsorption and activation of O2, form peroxy, superoxide and other active oxygen species, and improve the catalytic oxidation activity. According to the method, the covalence of Ce-O bonds is effectively reduced by destroying the periodicity of CeO2 crystal lattices. The reduction of covalence can weaken the constraint strength that surface lattice oxygen atoms are surrounded by Ce atoms and enhance the release reactivity of the surface lattice oxygen atoms essentially, so that the formation of oxygen deficiency is further promoted, the CeO2 adsorption is enhanced, the activity of activating O2 to form active oxygen for oxidation reaction is enhanced, and the oxidation reaction efficiency is improved. Furthermore, the catalyst has good catalytic performance on toxic and harmful substances such as chlorobenzene, sarin toxic agent simulation agents, CO and the like.

The invention discloses a preparation method of 2-oxo-4-phenyl oxazine sulfonyl fluoride, and belongs to the field of organic chemical synthesis. According to the method, in a specific tetrahydrofuran solvent, a cinnamyl (fluorosulfonyl) carbamate compound is used as a substrate and reacts under the action of a catalyst and alkali, and the 2-oxo-4-phenyl oxazine sulfonyl fluoride compound is obtained through the reaction. According to the method, iodobenzene diacetic acid and potassium tert-butoxide which are low in price and easy to obtain are adopted as the catalyst and alkali respectively, the substrate applicability is wide, the raw materials are simple and easy to obtain, the economic cost is low, and the target product can be obtained with the good yield.

This application relates to the field of functional crystalline material preparation and microfluidic application technology, specifically disclosing a method and product for preparing formate crystals using core-shell microcapsules, including the following steps: (1) dissolving a solid alkaline raw material in a formic acid solution to prepare reaction solution a; (2) separately conveying polymer solution A and polymer solution B with phase separation characteristics, and reaction solution a, so that they are mixed at the intersection of microchannels to prepare dispersed phase b, which is then introduced into the assembly zone for phase separation assembly to form core-shell microcapsules; (3) the core-shell microcapsules are crystallized in a continuous temperature-changing crystallization zone to form formate solid; (4) the formate solid is collected, washed and dried sequentially to obtain the target product; (5) the oil layer is continuously extracted and returned to the assembly zone for recycling. The formate crystals prepared in this application not only have a large particle size, but also exhibit good size uniformity and morphological repeatability, and have the advantages of high throughput, green environmental protection, and simple operation.

The present application relates to a kind of preparation method of vicinal diol compound, which comprises the following steps: in non-aqueous solvent, formula (I) compound and reducing agent are reacted under light condition, to obtain the vicinal diol compound shown in formula (II);The reducing agent is formic acid or formate;The wavelength of the light is less than 390nm;Its reaction formula is as follows.The preparation method of the present application does not need transition metal catalyst, also does not need other special catalyst and special additive, and the aldehyde ketone substrate can be reacted with formic acid or formate in solvent by specific wavelength of light, to obtain corresponding vicinal diol compound with high yield, its reaction condition is mild, has wide substrate applicability, and green and environmental protection, simple and practical operation method, provides an effective synthesis strategy for the synthesis of shikimic alcohol compound.

Described herein are methods of synthesizing a P2X3 antagonist wherein the P2X3 antagonist is a methyl (S)-2-((2-(2, 6-difluoro-4-(methylcarbamoyl) phenyl)-7-methylimidazo [1, 2-a] pyridin-3-yl) methyl) morpholine-4-formate (Compound 1), or a pharmaceutically acceptable salt or co-crystal thereof.