385 results about "Phosphine" patented technology

The invention discloses a rare-earth metal arylamine group compound as well as preparation method and application thereof. The invention discloses the rare-earth metal arylamine group compound which is characterized in that a general formula of the rare-earth metal arylamine group compound is (2,6-R12PhNH)5LnLi2(THF)2, wherein Ln is a rear-earth metal selected from one of neodymium, samarium, ytterbium or yttrium; R1 is selected from one of hydrogen, methyl or isopropyl. The rare-earth metal arylamine group compound has the advantages that the rare-earth metal arylamine group compound has a definite structure; raw materials used in the preparation method are simple, easily obtained and cheap; the reaction process is simple and easily operated; the rare-earth metal arylamine group compound product is conveniently purified and the yield of the product is high; the rare-earth metal arylamine group compound has a high activity when acting as a single component catalyst to catalyze a hydrogen phosphine reaction of aldehyde or ketone and phosphite ester; the use amount of the catalyst is less; the yield is high; a substrate has wide universality; a new and simple method is provided for synthesis of a-hydroxyphosphonate.

The present application relates to a kind of phosphine oxy group covalent modification composite adsorption material and its preparation method and purposes, the preparation method includes the following steps: (1) mixing dopamine hydrochloride, phosphine-containing substrate, tris-hydroxymethyl aminomethane hydrochloride and sodium hydroxide in solvent, to obtain mixed solution;(2) the mixed solution obtained in step (1) and solid phase material are mixed, then oscillation reaction is carried out, to obtain solid-liquid mixture;(3) the solid-liquid mixture obtained in step (2) is carried out solid-liquid separation, and the solid phase part obtained is sequentially washed and dried, to obtain phosphine oxy group covalent modification composite adsorption material.The phosphine oxy group covalent modification composite adsorption material provided by the present application has excellent adsorption selectivity and material stability, and can be used for the high-selectivity separation and recovery of rare metals indium and gallium.

The invention discloses a crystal compound, a preparation method thereof and application of the crystal compound in X-ray detection, imaging and anti-counterfeiting encryption, and belongs to the technical field of crystals. The molecular formula of the crystal compound is [Cu (totp) (CH3CN) 3] [Cu2I3 (totp) (PN)]. (CH3CN), wherein totp is tris (o-tolyl) phosphine; and PN is diphenyl-2-pyridine phosphine. The crystal compound disclosed by the invention is simple in preparation method, and has the characteristics of large mass attenuation coefficient of X-ray energy, high light yield and low detection limit when being used as a material of an X-ray detector. The compound also has the characteristic of structural transformation in solvents such as methanol, ethanol, acetone, dichloromethane, tetrahydrofuran and the like, and meanwhile, the conversion of luminescence color under the excitation of 365nm ultraviolet light and X rays is accompanied. The material can be applied to the aspects of scintillator materials, room-temperature X-ray radiation indirect detection materials, radiation detection dosimeters, X-ray scintillator medical imaging, anti-counterfeiting encryption and the like.

The application discloses a phosphine ligand modified nitrogen-doped graphene oxide / porous carbon supported metal catalyst and a preparation method and application thereof. The catalyst comprises phosphine ligand modified nitrogen-doped graphene oxide / porous carbon and rhodium supported on the nitrogen-doped graphene oxide / porous carbon; and the molar ratio of rhodium to phosphine is 1:1-100 in terms of elements. The phosphine ligand modified nitrogen-doped graphene oxide / porous carbon supported metal catalyst has better catalytic activity and product selectivity.

The application discloses a method for synthesizing organic acetylide ester through a palladium catalytic reaction and belongs to the field of organic synthesis. The organic acetylide ester is obtained through a cross-coupling reaction in the presence of a palladium catalyst, a phosphine ligand and an alkali, with terminal alkyne and di-tert-butyl dicarbonate as raw materials. The method has the advantages of high reaction yield, wide substrate range, good functional group compatibility, and the advantages of non-toxic and easy-to-obtain carbonyl source, simple operation steps and mild reaction conditions.

The invention relates to a synthesis method of a 3-olefine acid ester compound. The method comprises the following steps: carrying out contact reaction on an organic phosphine ligand, a palladium compound, conjugated olefin, an alcohol compound and carbon monoxide; wherein the structural formula of the organic phosphine ligand is shown in the specification, and in the structural formula, R0 and R1 are respectively selected from hydrogen, alkyl, alkoxy, halogen or halogenated alkyl; and R2 and R3 are respectively selected from hydrogen or alkyl. The method provided by the invention has the advantages of mild conditions, no need of an acid auxiliary agent, high yield and selectivity of the generated 3-olefine acid ester compound, reduction of corrosion to a reactor, and good application prospect, and the speculation is that the electrical property of phosphorus atoms can be regulated and controlled by using the organic phosphine ligand provided by the invention, so that the reaction activity of the palladium-organic phosphine ligand catalyst is regulated and controlled, and the yield and selectivity of the 3-olefine acid ester compound are improved. Therefore, the palladium-organic phosphine ligand catalyst generated by the ligand and a palladium compound in situ can efficiently catalyze the reaction of conjugated olefin, carbon monoxide and alcohol compounds.

The invention discloses a neutral phosphine phenol nickel catalyst based on a tert-butyl structure. The catalyst has a structure shown as a formula (I), wherein R1 and R2 are respectively and independently selected from hydrogen, C1-C20 alkyl, fluorine, chlorine, bromine, iodine, nitryl, hydroxyl, substituted silicon group and C1-C20 substituted alkyl; r3 is independently selected from C1-C20 alkyl, C1-C20 substituted alkyl, phenyl or substituted phenyl, R4 and R5 are independently selected from hydrogen, fluorine, chlorine, bromine, iodine, C1-C20 alkyl, aryl, an oxygen-containing group, a nitrogen-containing group, a sulfur-containing group, a boron-containing group, an aluminum-containing group, a phosphorus-containing group, a silicon-containing group or a tin-containing group; tert-butyl is introduced into para-position and meta-position of a ligand phenol oxygen ring, and a protection barrier is formed by utilizing the steric hindrance effect of the t-butyl, so that decomposition and deactivation of the catalyst under a high-temperature condition are inhibited, the catalyst can stably play a catalytic role in an industrial common medium-high-temperature polymerization environment, and the process adaptation range of the catalyst is widened.

The invention provides a temperature-resistant and salt-resistant polymer viscosity reducer for a drilling fluid and a preparation method of the temperature-resistant and salt-resistant polymer viscosity reducer. The phosphine-containing polymer viscosity reducer can be prepared from a carboxylic acid group-containing monomer, a sulfonic acid group-containing monomer, a phosphine-containing compound and phosphorous acid through a polymerization reaction; the carboxylic acid group-containing monomer is selected from one or more of acrylic acid, methacrylic acid and maleic acid, and the sulfonic acid group-containing monomer is selected from 2-acrylamido-2-methylpropanesulfonic acid or 2-acryloyloxy-2-methylpropanesulfonic acid; the phosphine-containing compound is selected from any one of ethylene diamine tetra (methylene phosphonic acid), 1-hydroxyethylidene-1, 1-diphosphonic acid and amino trimethylene phosphonic acid. The obtained phosphine-containing polymer viscosity reducer with the corresponding structure is good in temperature resistance and salt resistance, salt resistance reaches saturation, and under the conditions of high temperature and salt pollution, the viscosity reducer still has a good viscosity reduction effect and has good temperature resistance and salt resistance; and moreover, reaction raw materials in the preparation are few, the synthesis process is simple, the cost performance is relatively high, and application is facilitated.

The present application relates to the technical field of catalytic hydrogenation reaction, and discloses a preparation method and application of an organic phosphine shell modified nanocatalyst, which comprises the following steps: adding a carbon carrier in an alcohol solvent and ultrasonic dispersion, then adding a chloroplatinic acid containing alcohol solution, and stirring at 0-15 DEG C; subsequently, an organic phosphine containing alcohol solution and a reducing agent are added, and the stirring is continued; finally, rotary evaporation is carried out, and drying is performed to obtain the nanocatalyst; the nanocatalyst is a platinum catalyst with a core-shell structure loaded on the surface of the carbon carrier. By introducing the organic phosphine ligand to the surface of the nanometer platinum particles, the core-shell structure nanoparticles with a flexible organic phosphine ligand modified shell are constructed, the adsorption and desorption strength and configuration of the active site electronic structure, the reaction microenvironment, the reactants and the intermediate state of the reaction interface are regulated, and the selective and efficient hydrogenation of the aromatic hydrocarbon containing nitro or carbon-carbon double bond is realized.

This invention discloses a ruthenium catalyst supported on a phosphine-containing porous organic polymer and its preparation method. The phosphine-containing porous organic polymer serves as both a support and a solid ligand. The phosphine-containing porous organic polymer ligand is a random copolymer, and its structure can be represented by general formula I. The ruthenium catalyst supported on the phosphine-containing porous organic polymer according to this invention has a large specific surface area and contains a hierarchical porous structure, enabling efficient direct preparation of alcohols from olefins via reductive hydroformylation, and is easily recyclable. It exhibits excellent activity and regioselectivity in the direct preparation of alcohols from olefins via reductive hydroformylation, with an alcohol selectivity of nearly 90% and a high ratio of straight-chain alcohols to branched-chain alcohols.

The invention discloses a pre-transition metal compound containing nitrogen and phosphine as well as a preparation method and application of the pre-transition metal compound. The compound has a structure as shown in a formula (1). Wherein R1, R2 and R3 are each independently selected from a group consisting of H, a C1-20 alkyl group, a C1-20 alkoxy group and a halogen; r4 and R5 are each independently selected from a group consisting of H, a C1-4 hydrocarbyl group, a C6-12 aryl group, and a C7-16 aryl group substituted by a C1-4 hydrocarbyl group; mt is a group IVB metal element; m is equal to 1-3; r < 1 >, R < 2 >, R < 3 >, R < 4 > and R < 5 > are respectively and independently hydrogen, alkyl of C < 1-20 > or aryl of C < 6-30 >; e is O or S; x is an atom or group bonded to an Mt element, and X is at least one group selected from the group consisting of C1-10 hydrocarbon groups and halogens; and n is an integer and satisfies the valence of Mt bonding. The catalyst containing the compound has the advantages of high catalytic activity and low cost.

The application discloses a Cu / YPA catalyst, a preparation method and a preparation method of tris(3-hydroxypropyl) phosphine. The catalyst has high activity and good selectivity. The tris(3-hydroxypropyl) phosphine is prepared by adopting a three-step synthesis process. The reaction conditions of each step are mild, the required raw materials are simple, the yield of each step is high, the use of the toxic PH3 is avoided, and the industrial production is easy.

The application belongs to the field of organic synthesis, and discloses a method for preparing chiral 2-(1,3-diarylallyl)malonate by using a Pd / phosphine oxygen bidentate phosphine phenol ligand catalysis, which comprises the following steps: under a protective atmosphere, mixing P, O-bidentate phosphine phenol ligand, a palladium catalyst, N, O-bis(trimethylsilyl)acetamide, a malonate nucleophilic reagent and an allyl acetate electrophilic reagent in dichloromethane, and reacting to obtain chiral 2-(1,3-diarylallyl)malonate product. The system has the advantages of high enantioselectivity, high catalytic efficiency, wide substrate application range and mild conditions.

This invention discloses a chemical preparation method for pharmaceutical-grade dexborneol. The method employs Noyori asymmetric hydrogenation, asymmetric reduction of camphor, and the use of ruthenium as a catalyst. Under the action of phosphine ligands, dexborneol and a small amount of its isomer, isoborneol, are prepared. Then, under the action of trimethylchlorosilane, dexborneol, due to its spatial configuration, can form a silicon-oxygen bond with TMS, while isoborneol cannot. Isoborneol is removed by recrystallization to obtain a silyl ether protected compound of dexborneol. Dexborneol is then prepared under hydrochloric acid conditions and purified by recrystallization to obtain highly purified dexborneol. This route features mild reaction conditions, does not use highly toxic materials, and has a high yield, meeting the requirements for pharmaceutical-grade dexborneol.

The application discloses a kind of synthesis methods of high-purity electronic grade sodium hypophosphite, dilute phosphine gas is passed into to the mixed solution of sodium hypochlorite and sodium hydroxide that has been pre-cooled with sufficient stirring, and sodium hydroxide is added to carry out reaction;After reaction is completed, filtration, concentration, crystallization, separation are carried out, and the obtained product is purified by resin to obtain high-purity electronic grade sodium hypophosphite product.Compared with the traditional "yellow phosphorus-lime-soda" oxidation-reduction method for preparing industrial grade product and then preparing high-purity electronic grade sodium hypophosphite, the product purification difficulty of the application is low, by using 7N grade ultra-high purity phosphine without any metal impurities, the problem that arsenic, silicon, germanium, nickel, chromium and other metal impurities cannot be completely removed by traditional process can be effectively solved.In addition, the application also has the advantages of effectively solving the problem of three wastes, high recycling rate of by-products, high economy and the like.

A method of preparing an ionic liquid includes the following steps. A halogen-containing compound is reacted with a first compound to form a second compound. The halogen-containing compound includes a halohydrocarbon, a sulfonyl halide, or a combination thereof. The first compound includes an amine compound having a tertiary amine group, a phosphine compound, or a combination thereof. The second compound includes a first quaternary ammonium salt, a first quaternary phosphonium salt, or a combination thereof. The second compound and a lithium salt are reacted in a microwave device to form a third compound. The third compound includes a second quaternary ammonium salt, a second quaternary phosphonium salt, or a combination thereof. Anions of the second compound and the third compound are different. A microwave power of the microwave device is 700 watts to 1400 watts.

This application discloses a negative curvature polycyclic aromatic hydrocarbon containing an eight-membered ring, its synthesis method, and its application, belonging to the field of organic synthesis. The synthesis method uses a haloacenaphthene derivative as a starting material. First, a tetrahalogenated key intermediate containing an eight-membered ring is constructed via a titanium tetrachloride-catalyzed cyclization tetramerization reaction. Subsequently, this intermediate undergoes a cyclization coupling reaction with an alkyne compound in the presence of a palladium catalyst, silver salt, and phosphine ligand to generate a negative curvature polycyclic aromatic hydrocarbon containing an eight-membered ring. The synthesis method of this application avoids multi-step precursor synthesis, resulting in a concise process. It allows for the flexible introduction of functional groups such as trifluoromethyl and silyl groups, improving the solubility and processability of the material. The obtained product exhibits a non-planar configuration, a narrow optical band gap, and excellent electron transport properties, making it suitable for applications... n Applications include semiconductors, chiral optoelectronic materials, and nano-carbon materials.

The invention discloses a method for preparing a chiral benzhydrol compound through asymmetric hydrogenation of o-amido benzophenone under catalysis of rhodium. The chiral rhodium catalyst is generated in situ from a metal rhodium salt and a chiral phosphine-phosphoramidite ligand in various solvents. Compared with other methods for synthesizing chiral benzhydrol, the method has the characteristics of cheap catalyst, easiness in preparation of chiral ligand, mild reaction conditions, simplicity and convenience in operation, high yield, high enantioselectivity and the like, and can be applied to large-scale preparation of chiral benzhydrol compounds. The method is also suitable for efficient preparation of the rice plant growth regulation inhibitor (S)-Inabenide, the yield can reach 92%, the enantioselectivity can reach 96%, and the method has good industrial application prospects.

Provided herein are methods composition for treating lung cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of an imidazolate gold compound according to Formula I, or a pharmaceutically acceptable salt, racemate, or enantiomer thereof, wherein Formula I is a gold complex having a structure Au(L)(L′)n, wherein: n is an integer from 1 to 3; L is an imidazolyl-based N-heterocyclic carbene (NHC) ligand; and each L′ is independently selected from an imidazolyl-based NHC ligand, a triaryl phosphine, or a halide.

This invention belongs to the fields of extraction chemistry and chemical engineering, and discloses a multi-component enhanced cyclic lithium extraction system and its application method. The extraction system provided by this invention includes an extractant and a co-extractant; the extractant includes aliphatic hydrocarbon phosphates and acidic phosphine extractants; the co-extractant is Fe(III). This invention employs the separate addition of Fe(III) to both phases to enhance the separation effect of lithium from impurity elements Ca and Na during the extraction process. The lithium extraction method provided solves the problem of maintaining a high concentration of chloride ions in the extraction system to prevent Fe(III) loss. The washing and back-extraction processes have also been optimized, but no additional acid or alkali solutions are used, which improves the system's stability and has broad industrial application prospects.

The application belongs to the technical field of lithium ion batteries, and particularly relates to a silicon-carbon composite material and a preparation method and application thereof. The porous carbon material is contacted with a reaction gas to perform first chemical vapor deposition to obtain a first deposition product, the reaction gas comprising silane, a doping dilution gas and a carrier gas, wherein the doping source gas comprises diborane and / or phosphine; the first deposition product is contacted with a growth gas to perform second chemical vapor deposition to obtain a second deposition product, the second deposition product containing a graphene layer; and the second deposition product is contacted with a carbon source gas and an inert gas to perform third chemical vapor deposition to obtain the silicon-carbon composite material. The silicon-carbon composite material prepared by the application greatly improves the conductivity and structural stability of the material, so that the battery has high rate and long cycle life, and as a negative electrode material of a lithium ion battery, can meet the harsh demands of fast charging and high power output.

The present application relates to the field of basic organic chemistry synthesis, and particularly to a high-yield preparation method of o-terphenyl based on hydrogen participation; comprising the steps of preparing a catalyst mixed solution, preparing a reaction mixed solution, filling micro-pressure hydrogen, heating and hydrogenation coupling reaction, rough extraction through reduced pressure distillation, and recrystallization and drying; a pre-assembly reaction precursor is formed by a bidentate phosphine bidentate phosphine ligand and a supported palladium catalyst, and a coupling reaction occurs with diphenyl under the cooperation of micro-pressure hydrogen and an acidic cocatalyst; the present application does not need to use traditional halogenated aromatic hydrocarbons and organic metal reagents, solves the problems of isomer mixing and difficult separation and halogen residue affecting the performance of downstream optoelectronic materials, realizes the preparation of o-terphenyl, and simplifies the separation and purification process.

The invention discloses a synthesis method of halauxifen-methyl. The halauxifen-methyl is obtained by carrying out Suzuki coupling reaction on 4-amino-6-bromo-3-chloro-5-fluoropyridine carboxylic acid benzyl ester and 4-chloro-2-fluoro-3-methoxyphenylboronic acid, a catalytic system adopted by the Suzuki coupling reaction is a palladium catalyst, a phosphine ligand and a phase transfer catalyst; wherein the phosphine ligand is 4-(anthracene-9-yl)-3-(tert-butyl)-2, 3-dihydrobenzo [d] [1, 3] oxaphosphorus pentadiene, and the phosphine ligand is 4-(anthracene-9-yl)-3-(tert-butyl)-2, 3-dihydrobenzo [d] [1, 3] The molar use amount of the palladium catalyst is 0.1 to 0.5 mol percent of the molar use amount of the 4-amino-6-bromo-3-chloro-5-fluoropyridine benzyl formate. According to the invention, AntPhos is used as a phosphine ligand to form a catalytic system together with the palladium catalyst and the phase transfer catalyst, so that higher reaction yield and product purity can be obtained with very low dosage of the palladium catalyst, the synthesis cost of the halauxifen-methyl can be greatly reduced, the reaction condition is mild, the energy consumption is lower, and the method is suitable for industrial production.

To provide a method for obtaining an optically active hydrogen-phosphine borane compound at high optical purity. Also, to provide a method for obtaining an optically active 2,3-bis(dialkylphosphino)pyrazine derivative at high optical purity. Provided is a method for producing an optically active hydrogen-phosphine borane compound comprising carrying out a decomposition reaction of an optically active phosphine borane compound in the presence of a phase-transfer catalyst using an alkaline aqueous solution and an organic solvent. Also provided is a method for producing an optically active 2,3-bis(dialkylphosphino)pyrazine derivative using the optically active hydrogen-phosphine borane compound obtained.

The application provides a synthesis method of 1-substituted phenanthrene compounds, which comprises the following steps: mixing ortho-substituted aryl diazonium salt with KI, adding a palladium acetate catalyst, adding norbornadiene, adding a base, adding an organic phosphine ligand, adding 2-halobenzoic acid, heating to 80-150 DEG C in an aprotic solvent under a nitrogen atmosphere, and reacting for 2-10 hours to obtain the 1-substituted phenanthrene compounds. The method uses cheap and easily obtained ortho-substituted aryl diazonium salt instead of expensive aryl iodide to prepare 1-substituted phenanthrene compounds, and has the characteristics of easy raw material, mild conditions and simple operation, and is a simple synthesis method of 1-substituted phenanthrene compounds.

This invention discloses a microRNA-responsive 1,2-dioxane-based chemiluminescent compound, its dual-probe system, kit, synthesis method, and applications. The compound's core is an o-acrylate-substituted phenoxyadamantane-1,2-dioxane, with the phenolic hydroxyl group protected by an azide benzyl group. The two-component probe system constructed based on this compound comprises an azide-modified first probe and a phosphine-modified second probe, each complementary to different segments of the target microRNA. Hybridization brings the two probes closer, triggering a Staudinger reaction to remove the protecting group and activate the chemiluminescent signal. This probe system requires no enzyme amplification or nucleic acid extraction, achieves a detection limit of 1.37 fM, and a signal-to-noise ratio as high as 157-fold. It can be successfully used for real-time imaging of endogenous microRNA-21 in live cells, showing broad application prospects in early tumor screening, auxiliary diagnosis, and prognostic assessment.

The application discloses a wear-resistant EVA material and a preparation method thereof, and relates to the technical field of polymer materials. In the preparation of the wear-resistant EVA material, modified nano cellulose is prepared by reacting nano cellulose and a triazole type ultraviolet absorber; modified silicon dioxide is prepared by sequentially reacting silicon dioxide with 4-anilinoethyl triethoxysilane and 4-vinyl aniline; modified ethylene-vinyl acetate copolymer is prepared by sequentially reacting ethylene-vinyl acetate copolymer with allyl phosphine dichloride and eugenol; the modified ethylene-vinyl acetate copolymer, the modified nano cellulose, the modified silicon dioxide, hydrogen-containing silicone oil and chloroplatinic acid are melt-mixed to prepare the wear-resistant EVA material by compression molding. The wear-resistant EVA material prepared by the application has excellent wear resistance, flame retardation and anti-aging performance.

The application discloses a supported chiral phosphine heterogeneous catalyst and a preparation method and application thereof, and relates to the technical field of heterogeneous catalyst preparation. The method comprises the following steps: mixing hollow mesoporous polystyrene nanospheres, chiral phosphine and DCE, stirring, adding FDA, stirring, adding concentrated sulfuric acid dropwise, and reacting to obtain a reactant one; and mixing the reactant one, toluene, tetramethyldisiloxane and tetraisopropyl titanate, and reacting under temperature rise to obtain the supported chiral phosphine heterogeneous catalyst. The application is simple and convenient in a one-pot method, and can efficiently anchor the chiral phosphine and its oxide catalyst to the carrier. The application solves the problems of complicated modification in the existing organic catalyst immobilization process and mass transfer limitation of the prepared catalyst.

Provided is a novel photothermal conversion material. A manganese oxide cluster compound represented by general formula (1). (In general formula (1), L is a tricarboxytriptycene residue, alpha1 is an organic acid residue, beta1 is a solvent selected from the group consisting of water and a polar organic solvent having a dielectric constant of 6-47, P1 is a coordinating molecule selected from the group consisting of a nitrogen-containing heterocyclic compound, an oxygen-containing cyclic compound and a phosphine, or a polymer containing the coordinating molecule, [gamma] 1 is a solvent selected from water and a polar organic solvent having a dielectric constant of 6-47, q is a number of 0 < = m < = 8, and m is a number of 0 < = m < = 10. ).

The application provides a synthesis method of 4-(hydroxymethyl phosphine) 2-carbonyl butyric acid, comprising the following steps: a) mixing acryloyl chloride, a first solvent, a polymerization inhibitor, a catalyst and sodium cyanide, performing a substitution reaction, and obtaining an acryloyl cyanide intermediate after reduced pressure distillation; b) mixing the acryloyl cyanide intermediate obtained in the step a) with hydrochloric acid and a polymerization inhibitor, performing a hydrolysis reaction, and obtaining 2-carbonyl-3-butenoic acid crude product after purification treatment; c) mixing the 2-carbonyl-3-butenoic acid crude product obtained in the step b) with a second solvent and methyl phosphinite, performing an addition reaction, recovering the solvent after water separation and extraction, and obtaining a ketonic acid ester solution; and d) adding hydrochloric acid to the ketonic acid ester solution obtained in the step c) to adjust the pH to be less than or equal to 3, performing a hydrolysis reaction, and obtaining 4-(hydroxymethyl phosphine) 2-carbonyl butyric acid after purification. The synthesis method selects inexpensive acryloyl chloride as a raw material, has mild reaction conditions, is simple to operate, has low production cost, is easy to realize industrialization, and has high yield.