168 results about "Enantiomer" patented technology

The invention belongs to the field of detection and analysis, and relates to a method for separating and detecting enantiomers in (S)-2-amino-3-[2-(tert-butoxy)-2-oxoacetamido] tert-butyl propionate hydrochloride. According to the method, HPLC is adopted for separation and detection, a polysaccharide derivative chiral chromatographic column is selected as a chromatographic column, a mobile phase A is a weak base aqueous solution, and a mobile phase B is acetonitrile and / or methanol. The method is strong in specificity, high in separation degree, high in accuracy, stable, reliable and high in sensitivity, and a simple, accurate, rapid and reliable detection method is provided for control of impurities in a starting material of (S)-2-amino-3-[2-(tert-butoxy)-2-oxoacetamido] tert-butyl propionate hydrochloride.

The invention provides a method for determining the content of penicillamine enantiomers by pre-column derivatization liquid chromatography, namely a method for detecting L-penicillamine in D-penicillamine or a method for detecting D-penicillamine in L-penicillamine, derivatization is carried out under conventional alkaline conditions, a termination reaction is carried out by conventional acid, the derivatization steps are simplified, the detection efficiency is improved, and the detection cost is reduced. According to the method, various interferences of other amino acids and corresponding isomers in the raw materials can be effectively avoided due to the gradient of the mobile phase, the damage to a chromatographic column is well reduced due to the fact that conventional reagents such as phosphoric acid and acetonitrile serve as the mobile phase, and the method is easy to operate, high in sample preparation speed and high in accuracy. The method has the advantages of strong anti-interference capability, good separation effect, high sensitivity, accurate result and good stability, realizes effective separation of penicillamine isomers, has a separation degree of greater than 2, can perform content determination on another main drug while performing impurity detection on one isomer, and has good practicability.

The invention discloses a composite material modified electrode based on a functionalized single-walled carbon nanotube and application thereof, and belongs to the technical field of electrochemistry, the modified electrode comprises a glassy carbon electrode and a functionalized single-walled carbon nanotube-glucose composite material coating coated on the surface of the glassy carbon electrode; the mass ratio of functionalized single-walled carbon nanotubes to glucose in the coating is (0.2-5): 1, and the functionalized single-walled carbon nanotubes comprise at least one of hydroxylated single-walled carbon nanotubes, carboxylated single-walled carbon nanotubes and aminated single-walled carbon nanotubes, preferably hydroxylated single-walled carbon nanotubes. The composite material modified electrode provided by the invention has a large number of active sites, and by effectively utilizing the synergistic effect of the hydroxylated single-walled carbon nanotubes and glucose, the modified electrode shows excellent selective recognition capability on amino acid enantiomers and also shows good stability; and the method has a good application prospect in quantitative analysis of the amino acid enantiomers.

The invention discloses an enhanced Raman scattering substrate for chiral molecule detection and a preparation method, and relates to the technical field of spectral analysis and chiral recognition. Chiral cysteine is induced at the core of the gold nanorod to form a spiral chiral gold-silver alloy layer and then wraps the zirconium-based metal organic framework, the synthesized chiral gold rod (at) MOF material has excellent LPSR effect and chiral electromagnetic field, and the MOF layer on the surface can well adsorb molecules to be detected to enter a plasma hot spot area. The Raman substrate is excellent in SERS performance. According to the composite material, through the dual effects of molecular enrichment and electromagnetic enhancement, enantiomers are distinguished directly through SERS intensity, and labeling or catalytic conversion is not needed.

The invention discloses a dynamic tunable chiral terahertz broadband absorber based on vanadium dioxide, the absorber is formed by periodically arranging M * N absorption units of a multilayer structure in an array, the absorption units are in M * N two-dimensional distribution, and both M and N are positive integers; the absorption unit comprises a metal substrate, a dielectric layer and a resonance layer which are sequentially arranged from bottom to top; the metal substrate and the dielectric layer are rectangular; the resonance layer comprises a J-shaped metal patch, and an inverted-T-shaped vanadium dioxide patch is arranged at one end of the J-shaped metal patch. The terahertz chiral absorber can have a circular dichroism (CD) value larger than 0.8 within the range of 5.36-7.69 THz, the mirror image enantiomer of the terahertz chiral absorber can also achieve a CD spectrum opposite to the mirror image enantiomer, and the terahertz chiral absorber has the advantages of being high in CD, dynamically tunable and simple in structure. In addition, the invention also discloses a preparation method of the dynamic tunable chiral terahertz broadband absorber based on vanadium dioxide.

The invention provides a fullerene pyrrolidine enantiomer mediated cholesteric liquid crystal with circular polarization luminescence property and nonlinear anti-saturated absorption property, and a preparation method and application thereof. The method comprises the following steps: dissolving C60, paraformaldehyde and (R / S)-(+ / -)-alpha-methylbenzylamine in an organic solvent, and carrying out heating reflux reaction to obtain fullerene pyrrolidine enantiomer molecules; dissolving in carbon disulfide to obtain an enantiomer solution; dissolving achiral dye molecules in a solvent to obtain a dye solution; and dropwise adding the enantiomer solution and the dye solution into thermotropic liquid crystal molecules, and drying to obtain the thermotropic liquid crystal. The method is simple, the obtained cholesteric liquid crystal system shows a characteristic fingerprint texture and has a periodic spiral structure, and the doping proportion of chiral molecules is easy to adjust; the composite system has good time stability and is not prone to phase separation; the liquid crystal platform shows good circular polarization luminescence performance and third-order nonlinear optical property, and is a cholesteric liquid crystal platform with an integrated function.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a detection method of an evocamide enantiomer, which comprises the following steps: S1, preparing a test solution; s2, preparing a contrast solution; s3, preparing a system applicable solution; s4, carrying out a system applicability test; s5, testing a test sample and a contrast solution; a chromatographic column is a chiral chromatographic column taking a polysaccharide derivative or a cellulose derivative as a filler, and a mixed solution of n-hexane, isopropanol, trifluoroacetic acid and diethylamine is taken as a mobile phase to detect the Evocadum enantiomer. The method has the characteristics of simplicity in operation, high sensitivity and high accuracy, the chromatographic peaks are high in separation degree, do not interfere with one another, the peak shape is good, the result accuracy is guaranteed, the method can be used for detecting enantiomers in the Evocamide and the Evocamide preparation, the level of the enantiomers of the Evocamide is effectively controlled, and the medication safety is guaranteed.

To provide a simple method for optically resolving a chiral compound, which is expected to be industrially applicable.SOLUTION: A method for optical resolution of a chiral compound includes dissolving a mixture of both enantiomers of the chiral compound in a first solvent to prepare a first solution, stirring the prepared first solution, precipitating a first gel in the stirred first solution, and separating the first solution into the first gel and a first supernatant.SELECTED DRAWING: Figure 1

The invention discloses an enantiomer crystallization resolution method of delta-dodecalactone, which comprises the following steps: hydrolyzing delta-dodecalactone under an alkaline condition for ring opening, acidifying to obtain 5-hydroxylauric acid, adding a dehydroabietylamine solution, dissolving in an alcohol solvent or a solvent system consisting of the alcohol solvent and other solvents, fully reacting, cooling, slowly crystallizing, filtering, washing, and drying to obtain the delta-dodecalactone enantiomer. Filtering, adding ethyl acetate and hydrochloric acid into a filter cake for dissolving, carrying out liquid-liquid extraction and washing an organic phase, and carrying out rotary evaporation concentration on the organic phase to obtain optically enriched delta-dodecalactone; the method is simple to operate and does not depend on expensive special equipment, and the sample loading amount is greatly increased; due to the introduction of dehydroabietylamine, the 5-hydroxylauric acid and the dehydroabietylamine form diastereoisomer salt, and chiral separation is carried out in the crystallization process; the reaction safety is high, and the requirements of green chemistry are met.

An unnatural amino acid, where the unnatural amino acid is a compound with a structure as shown in formula (I) or an enantiomer thereof,where X represents —O—, —S—, —NH— or —CH2—, Y represents —O—, —S—, —C(O)—, —S(O)— or —CH2—, and L represents substituted or unsubstituted C0-C20 linear or branched alkylene, where one or more —CH2— are optionally substituted by one or more of —O—, —S—, —NH—, —C(O)— and —S(O)—, when X represents —O— and Y represents —C(O)—, L does not represent —CH2CH2—, and when L represents a substituent, the substituent is selected from one or more of hydroxyl, sulfhydryl, halogen, nitro, cyano, alkyl, alkenyl, alkynyl, alkoxy, acyl, acylamino, carboxyl, ester, amino, sulfonyl, sulfinyl, cycloalkyl, heterocyclyl, aryl and heteroaryl.

The present invention provides a method for detecting and identifying molecular chirality based on a composite plasmon chiral nanostructure. The present invention constructs a composite plasmon chiral nanostructure using chiral nanofibers and gold nanorods as basic components, and achieves molecular chirality recognition and detection through plasmon chiral optical amplification. The excellent plasmon circular dichroism optical properties of the composite nanostructure can convert the host-guest chiral recognition interaction occurring at the fiber interface into an asymmetric plasmon chiral optical amplification signal. This technology can detect and identify the chiral enantiomers of amino acid molecules in about 1 minute, with a sensitivity of 10 ‑6 mol / L. This structure can also be used for quantitative analysis of molecular enantiomeric excess (ee), with a detection sensitivity of ±0.05. Furthermore, given that the chiral host-guest complexes involved in this technology are primarily based on hydrogen bonding interactions, the chiral fiber host can be used as a universal substrate for the detection of chiral amino acid molecules.

This invention belongs to the field of membrane separation and functional membrane materials technology, and discloses a chiral graphene oxide-based separation membrane, its preparation method, and its application. The membrane is composed of graphene oxide and / or reduced graphene oxide sheets and a single-stranded DNA-single-walled carbon nanotube complex. The single-stranded DNA helically winds around the outer surface of the single-walled carbon nanotubes to form a one-dimensional chiral nanochannel and intercalates between the sheets, forming a three-dimensional chiral channel network connected in the membrane thickness direction. The preparation method includes: heating and decohexing salmon sperm double-stranded DNA in a urea-containing buffer to obtain single-stranded DNA; dispersing single-walled carbon nanotubes and then complexing them with the single-stranded DNA; further mixing with a graphene oxide or reduced graphene oxide dispersion; and vacuum filtration to form the membrane. This membrane exhibits a high separation factor for chiral enantiomers such as L / D-phenylalanine, with an excess value of up to 99.95% for L-phenylalanine enantiomers after multi-stage separation, making it suitable for the efficient separation of chiral drugs and amino acids.

The invention relates to a method for analyzing and detecting a non-azonetin enantiomer, which adopts normal-phase high performance liquid chromatography and takes normal hexane-ethanol-trifluoroacetic acid as a mobile phase to detect the non-azonetin enantiomer, and the specific chromatographic conditions are as follows: a chromatographic column is prepared by covalently bonding amylose-tri (3, 4, 6-trimethyl-1, 3-pentanediol) on the surface of silica gel; 2, 5-dichlorophenyl carbamate is used as a filling agent (IE, 4.6 * 250 mm, 5.0 [mu] m); a mobile phase: n-hexane: ethanol: trifluoroacetic acid = 500: 500: 1 (V / V / V); the flow rate is 1.0 ml / min; the column temperature is 30 DEG C; the sample size is 20 [mu] l; the detection wavelength is 280 nm; the elution gradient is isocratic elution. The invention provides a high performance liquid chromatography method for analyzing the enantiomer of the fiazonetin, the complete separation of the fiazonetin and the enantiomer of the fiazonetin can be realized by adopting the method, and the separation degree of a main component and the enantiomer is greater than 1.5.

The present invention belongs to the field of organic chemical ligands and discloses a nitrogen-nitrogen-phosphorus ligand having a structure of the general formula I or its tautomers, enantiomers, and diastereomers: #imgabs0#R 1 、R 5 R is independently selected from hydrogen, alkyl, alkoxy, cycloalkyl, alkenyl, alkynyl, hydroxyl, aldehyde, carboxyl, ester, halogen, trifluoromethyl, cyano, acyl, amide, amino, nitro, phenyl, benzyl, sulfonyl, sulfonic acid, and mercapto; 2 is selected from one of the following structures: alkyl, alkoxy, cycloalkyl, alkenyl, alkynyl, phenyl, benzyl, phenethyl, naphthylmethyl, -CHPh2, ester, -CH2OBn, or substituted phenyl or benzyl, or R 2 With R 4 connected to form a five-membered ring and an acene ring; the R 3 is selected from hydrogen or alkyl; said R 4 is selected from hydrogen, alkyl, alkoxy, alkenyl, alkynyl, phenyl, benzyl; W is PR2 or P(O)R2, and R is selected from phenyl, naphthyl, cyclohexyl, and substituted phenyl. The present invention also discloses a preparation method and use of nitrogen-nitrogen-phosphorus ligands.

The invention discloses a spiral chiral gold nanorod as well as a preparation method and application thereof, and the method comprises the following steps: (1) sequentially adding hexadecyl trimethyl ammonium bromide, cysteine and p-aminothiophenol into an anisotropic gold nanorod solution, uniformly mixing, and adsorbing; and (2) silver nitrate, chloroauric acid and ascorbic acid are added for a reaction, centrifugal dispersion is performed after the reaction is finished, and the spiral chiral gold nanorod is obtained. Dispersing the spiral chiral gold nanorod in an aqueous solution, adding phenylalanine enantiomer, dropwise adding on a clean glass slide after incubation is finished, and performing surface enhanced Raman spectroscopy test by using a Raman microscope after air drying. According to the invention, the broadband coverage of chiral response from visible light to near ultraviolet region is realized by accurately regulating and controlling the arrangement of interface molecules and the morphology of the nano structure.

The invention belongs to the technical field of analytical chemistry, and particularly relates to a multifunctional chiral selection reagent solution (CSS) and application of the multifunctional chiral selection reagent solution. More specifically, the invention relates to a multifunctional chiral selection reagent solution for chiralMS (chiralMS) analysis, and the solution is prepared from CuCl2, D-Phe, L-Ph-d5 and D-or L-3'and / or 4 'hydroxyl substituted Kelin lactone. According to the present invention, the on-line non-covalent derivatization can be performed on the enantiomers in the complex system sample by using the multifunctional chiral selection reagent solution and by using the post-column injection liquid chromatography-mass spectrometry (post-column injection liquid chromatography-mass spectrometry / MS, PCI-LC-MS / MS) system so as to achieve the qualitative and quantitative analysis of the enantiomers and the rapid screening of the chiral selection reagent (CS).

The application belongs to the technical field of analysis and detection, and discloses a chiral detection platform based on a hydrogel SERS chip and application thereof.The core of the application is that the inherent chiral structure of a hydrogel matrix in a specific hydrogel SERS chip is found and utilized for the first time, so that specific enantiomers of chiral molecules can be directly and highly selectively recognized and detected without any exogenous chiral modifier or complex separation process.When the chip is used for detection with levomeprazole as a model analyte, only levomeprazole can be selectively adsorbed and produce a strong characteristic SERS signal, and the response of the dextrogyratory enantiomer is weak under the optimal conditions of an acid medium with pH 4.The sensor constructed by the method exhibits high sensitivity to levomeprazole, and the detection limit reaches 1.0x10 ‑7 mol / L, excellent selectivity and good anti-biological matrix interference capability, thereby providing a novel, simple and efficient solution for rapid analysis of chiral drugs.

The invention discloses a method for directly preparing a racemic oxidation product from a fennerenone enantiomer through photocatalysis, and belongs to the technical field of organic synthesis.The method comprises the steps that an R-type fennerenone isomer is taken to be placed in a reaction bottle, a photosensitizer containing iridium or ruthenium is added, and a solvent is added at the speed of 0.1 M in the air atmosphere; the method comprises the following steps: dissolving 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2, 8-dimethyl-1, 6-naphthyridine-3-formamide in a solvent, stirring, transferring a mixture into a photoreactor of a blue light LED (Light Emitting Diode) with the wavelength of 455-465 nm, stirring, transferring a mixed solution after the reaction is finished into a round-bottom flask, purifying a volatile solvent to obtain a product 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2, 8-dimethyl-1, 6-naphthyridine-3-formamide, and carrying out chiral HPLC (High Performance Liquid Chromatography) analysis on the product. High temperature, high pressure or a strong oxidant is not needed, and reaction conditions are mild; oxygen in air is oxidized at room temperature, so that energy consumption and pollutant generation are reduced; compared with the traditional oxidation condition, the method does not need to undergo the process of oxidation first and then high-temperature induced racemization, and the racemization product can be directly obtained.

The application discloses a kind of plane chiral [2.2] paracyclophanane monophosphine ligand pEPCP and preparation method and application thereof, it is related to chemical catalysis technical field, and its technical scheme main points are as follows: including racemate or enantiomer, the structural formula-I of the monophosphine ligand pEPCP of the application is as follows: [2.2] paracyclophanane skeleton containing monophosphine ligand pEPCP of the application, with two benzene rings in para position by two ethylene connection unique big steric hindrance, electron-rich rigid skeleton, different types ether substituent group is introduced in structure, change the electron cloud density and steric hindrance of aromatic ring directly connected by phosphine ligand.In addition, ether substituent group can also be used as weak coordination group, participate in adjusting ligand chelate dihedral angle.This makes metal, ligand and substrate form the most suitable coordination environment in catalytic process, so that corresponding catalytic reaction has the advantages such as high reactivity, good enantioselectivity, substrate universal range is wide, especially suitable for transition metal catalyzed asymmetric coupling reaction, with economic practicability and industrial application prospect.

The invention discloses a normal-phase chromatographic analysis and detection method for a tiagonium bromide intermediate and an enantiomer of the tiagonium bromide intermediate, and belongs to the technical field of analytical chemistry. The method comprises the following steps: preparing a system applicability solution, a test solution and a contrast solution; setting liquid chromatography detection conditions, and adopting a normal phase chromatographic column with cellulose-tri (3, 5-dimethyl phenyl carbamate) coated silica gel as a filling agent; finally, the system applicability solution, the test solution and the contrast solution are taken and injected into a liquid chromatograph, and chromatograms are recorded. The detection method can be used for rapidly detecting the content of enantiomer impurities in the tiagradionium bromide intermediate, is high in specificity and separation degree, and can be used for well separating an R-configuration tiagradionium bromide intermediate and an S-configuration enantiomer impurity; the method has the advantages of high sensitivity and good repeatability, and can accurately quantify the content of enantiomer impurities in the tiagradionium bromide intermediate.

The invention discloses a chiral phenol calix [4] aryl porous organic molecular cage material as well as a preparation method and application thereof. A chiral calix [4] arene raceme and an acyl chloride chiral auxiliary agent are used as initial raw materials to react to prepare a pair of diastereoisomers, gram-grade separation is achieved through silica gel column chromatography, then the chiral auxiliary agent is removed respectively, and the single enantiomer chiral phenol calix [4] arene compound with the ee value being 99.9% or above can be obtained. The preparation method comprises the following steps of: synthesizing tetraaldehyde chiral phenol calix [4] arene by introducing an aldehyde group unit on the tetraaldehyde chiral phenol calix [4] arene through Duff reaction, and assembling the tetraaldehyde chiral phenol calix [4] arene serving as a construction element with a polyamino organic synthesizer to prepare the chiral phenol calix [4] arene porous organic cage with a larger cavity. The preparation method of the chiral porous organic cage does not need a catalyst, the preparation process is simple, operation is easy and convenient, expansibility is good, the yield is high, and the prepared chiral molecular cage is large in cavity, large in specific surface area and good in repeatability and can be used for chiral recognition and gas adsorption.

The invention discloses a flavonoid enantiomer compound extracted from Epimedium sagittatum and its preparation method and application. The preparation method comprises the following steps: crushing Epimedium sagittatum to prepare a paste, suspending the paste with water, extracting the paste with petroleum ether, dichloromethane, ethyl acetate and n-butanol respectively to obtain extracts of each part, performing gradient elution separation by silica gel column chromatography, combining similar parts according to the color development results of thin layer chromatography (TLC) to obtain multiple polar segments; chromatographing the target polar segment and performing gradient elution to obtain multiple components, and then combining similar components by thin layer chromatography (TLC) spot plate absorption to obtain multiple sub-components; eluting and purifying the target sub-components, collecting fractions with different retention times, and drying to obtain four compounds respectively. The four compounds have a significant inhibitory effect on the cell viability of human breast cancer MCF-7 cells and have anti-breast cancer activity. The four compounds can be used in the preparation of drugs for treating breast cancer, with huge social and economic benefits.

This application discloses a method for synthesizing chiral cyano-containing full-carbon quaternary cyclic compounds, characterized by the following steps: mixing a solvent, an oxidant, an alkynyl malononitrile compound, a carboxylic acid compound, a palladium salt, and a chiral dinitrogen ligand; reacting the mixture; drying; and separating to obtain the chiral cyano-containing full-carbon quaternary cyclic compound. This method can achieve a palladium-catalyzed tandem reaction of alkynyl malononitrile with a carboxylic acid involving asymmetric acyl oxidative cyclization / acyl migration, yielding cyano-containing full-carbon quaternary cyclic compounds with optical purity in good yields (enantiomer ratios up to 96.5:3.5). This invention features a broad substrate range, readily available raw materials, simple and practical operation, and mild reaction conditions.

According to the invention, a hydrothermal synthesis method is adopted to prepare the chiral enantiomer of the Beta zeolite molecular sieve with optical rotation. The molecular sieve has a chiral pore channel with a single enantiomer structure, shows excellent selectivity and stability in selective adsorption and resolution of chiral molecules, and has great potential application value in the fields of fine chemical engineering, drug separation and the like.

This invention belongs to the field of organic ligand technology, and specifically discloses a phosphoxazolin ligand having the structure shown in general formula I or general formula II, or its tautomers, enantiomers and diastereomers: , R 1 Selected from hydrogen, alkyl, perfluoroalkyl, alkoxy, aryl; R 2 Selected from hydrogen, alkyl, perfluoroalkyl, alkoxy, aryl; R 3 Selected from alkyl, cycloalkyl, alkenyl, and aryl; R 4 Selected from alkyl, cycloalkyl, alkoxy, perfluoroalkyl, aryl, and fluorine atoms; R 5 Selected from hydrogen, alkyl, cycloalkyl, alkoxy, perfluoroalkyl, aryl, and fluorine atoms; R 6 The substituents are selected from hydrogen, alkyl, cycloalkyl, alkoxy, perfluoroalkyl, aryl, and fluorine atoms; n and m are the number of substituents, where n+m≤5. This invention also discloses a method for preparing phosphosoxazoline ligands and their application in catalytic allylation, bicyclization, intermolecular desymmetry, or intramolecular condensation reactions of nitrile derivatives.

Compounds of formula (I) or their pharmaceutically acceptable salts, hydrates, solvates, esters or their optical isomers, racemates, diastereoisomers, enantiomers, tautomers, or a mixture thereof; said compounds exhibits anti-plasmidal activities, in particular for the treatment of malaria diseases.

The present invention relates to cocrystalline forms of 4-[4-[3- chloro-4-[l-(5-fluoro-2-pyridyl)-2-hydroxy-ethoxy]pyrazolo[l,5- a]pyridin-6-yl]-5-methyl-triazol-l-yl]piperidine-l-carbonitrile, R- enantiomer ("Isomer 2"), with gallic acid (I), and to cocrystalline forms of 4-[4-[3-chloro-4-[l-(2-pyridyl)-2- hydroxy-ethoxy]pyrazolo[l,5-a]pyridin-6-yl]-5-methyl-triazol-l- yl]piperidine-l-carbonitrile, R-enantiomer ("Isomer A"), with gallic acid or nicotine amide (II) The compounds are fibroblast growth factor receptor 3 (FGFR3) inhibitors for use in methods of treatment of e.g. cancer. Provided herein are also methods for the preparation of said cocrystalline forms.

The invention belongs to the chemical field of porphyrin and isoporphyrin dimers, discloses a preparation method of a novel chiral macrocyclic dimer, and aims to solve the problems of complex synthesis, poor selectivity and difficulty in introduction of a chiral unit in the prior art. The method comprises the following two steps: at room temperature, reducing a misplaced tetrapyrrole diacylation raw material by sodium borohydride to obtain an intermediate misplaced tetrapyrrole diol I-1; and carrying out condensation, DDQ oxidation and silica gel column chromatography purification on the intermediate and meso-free tetrapyrrole I-2 at room temperature under a dark condition to obtain two target products which are isomers of each other. The product contains a chiral carbon center, is in an asymmetric configuration, can be used for splitting enantiomers, has adjustable spectral properties, is simple and efficient in synthesis steps, provides a new basis for development of chiral optical materials, and expands the application potential in the fields of catalysis, photoelectric materials and the like.

The present invention discloses a chiral heteroleptic nine-coordinate rare earth complex and its preparation method and application, belonging to the field of organic luminescent materials. This chiral rare earth complex consists of three anionic coumarin-derived diketone ligands (Coum) ‑ The chiral bis-oxazoline-derived enantiomerically pure ligands 1R,2R-2,6-bis(4-phenyl-2-oxazoline-2-yl)pyridine (1R,2R-Ph-PyBox) or 1S,2S-2,6-bis(4-phenyl-2-oxazoline-2-yl)pyridine (1S,2S-Ph-PyBox) were self-assembled with rare earth ions in alcohol solution. Thanks to the combination of the excellent photophysical properties of the Coum ligand and the strong chiral induction ability of the chiral Chiral-Ph-PyBox ligand, the two Tb 3+ The enantiomers [Tb(Coum)3(1R,2R‑Ph‑PyBox)](2)and[Tb(Coum)3(1S,2S‑Ph‑PyBox)](5) not only achieve bright and high color purity characteristic green emission (Φ PL =74%), and also obtained a strong excited state CPL activity (|g lum |=0.097‑0.103) and significantly enhanced antenna ligand center absorption behavior (ε 320nm =47820-47940M ‑1 cm ‑1 ). Complexes 2 and 5 have magnetic dipoles 5 D4→ 7 The circular polarization brightness at the F5 transition position (B CPL ) can be as high as 1132.7-1205.8M ‑1 cm ‑1 .

This invention relates to a dual-mode chiral sensing platform, its preparation method, and its application for identifying amino acid enantiomers, belonging to the field of electrochemical sensing technology. The preparation method includes the following steps: preparing an MXene-gold nanoparticle-N-acetyl-L-cysteine ​​chiral solution; preparing an MXene-gold nanoparticle-N-acetyl-L-cysteine / L(D)-amino acid solution; preparing an MXene-gold nanoparticle-N-acetyl-L-cysteine ​​modified electrode; electrochemical chiral recognition of amino acid enantiomers; and temperature-based chiral recognition of amino acid enantiomers. This invention utilizes MXene, a two-dimensional nanomaterial with excellent conductivity and photothermal conversion capabilities, as a carrier to in-situ load gold nanoparticles. N-acetyl-L-cysteine ​​containing a thiol group at the end is captured through Au-S bonds. This chiral material can achieve chiral recognition of amino acid enantiomers through both electrochemical and temperature-based chiral sensing modes.