Methods and apparatus for the ion mobility based separation and collection of molecules

a technology of ion mobility and method, applied in the field of methods and apparatus for the ion mobility based separation and collection of molecules, can solve the problems of difficult rapid and efficient separation and collection of chiral compounds, time-consuming process, and many drawbacks of traditional enantiomer preparation processes, so as to achieve enhanced separation and collection
US20080173809A1Inactive Publication Date: 2008-07-24EXCELLIMS CORP
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
EXCELLIMS CORP
Publication Date
2008-07-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention describes an apparatus for the separation and collection of components in a sample of interest comprising: an ionization source; an ion mobility separator and an ion collector positioned to receive ions leaving the ion mobility separator. The ion mobility separator having an inlet to supply at least one separating substance which comprises particles which selectively interact with at least one analyte component of interest to certain degree different from the others. The analyte component of interest may be enantiomers, diastereomers, stereoisomers, isomers, etc. The ion collector can be used to conduct analytical, preparative, and semi-preparative separation. In addition, a combined primary electrospray and secondary electrospray ionization source is disclosed to enhance ionization efficiency of interest.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] The present application claims the benefit of and priority to corresponding U.S. Provisional Patent Application No. 60 / 807,031 and 60 / 891,532, filed Jul. 11, 2006 and Feb. 26, 2007 respectively, the entire content of the applications are herein incorporated by referenceBACKGROUND OF THE INVENTION

[0002] Enantiomerically pure compounds are of great interest in the pharmaceutical industry and other fields. The rapid and efficient separation and collection of chiral compounds is difficult since they have the same physical properties. All of their physical properties correspond, except the direction in which they rotate plane-polarized light, i.e. they differ in a specific optical activity. Furthermore, all of their chemical properties correspond, except the reactivity toward other chiral compounds. Note that the term chiral compounds are also often used as a general term that refers to the molecules with a chiral center. Development of both pr...

Claims

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