630results about "Isotope separation" patented technology

The invention discloses a method for continuously and efficiently adsorbing and separating hydrogen isotopes. The hydrogen isotopes are separated by adopting a multi-tower variable-temperature variable-pressure device operated in a simulated moving bed operation mode. When the device runs, each adsorption tower needs to sequentially execute the following steps: 1, adsorption; 2, replacement; 3, heating; 4, vacuumizing and desorbing; 5, carrying out vacuum purging; 6, pressurizing and cooling; the operation mode of the simulated moving bed is that an adsorption tower is frequently, sequentially and synchronously moved along the gas flowing direction in the tower through all gas input and output ports, so that an adsorbent phase and a gas flowing phase in the tower form countercurrent flow, and the hydrogen isotope adsorption separation efficiency is enhanced. The invention relates to a technological process of cyclic adsorption, replacement, heating, vacuum desorption, pressurization and cooling, continuous and efficient hydrogen and isotope adsorption separation is realized, multi-tower serial adsorption and replacement are adopted in the process, and separation of hydrogen isotopes (such as H2 / D2) is enhanced; and the desorption efficiency of heavy components is improved by adopting a heating and vacuumizing depressurization coupling mode.

The invention relates to the technical field of low-temperature adsorption and isotope separation, in particular to a low-temperature helium isotope adsorption separation system and a low-temperature helium isotope adsorption separation method, and the system comprises a gas distribution and gas recovery module which is used for preparing and mixing helium isotope raw material gas and recovering residual gas after an experiment; the static testing unit is used for testing the performance of the adsorbent under a fixed condition; the dynamic low-temperature adsorption unit is used for helium isotope separation under a continuous flow condition; the low-temperature control module is used for providing a stable low-temperature environment and accurate temperature control; wherein an air inlet pipe and an air outlet pipe of the low-temperature control module are respectively subjected to thermal sedimentation and are respectively connected with a flow controller. According to the scheme, the defects that in the prior art, He resources are seriously short, and existing low-temperature adsorption separation helium isotope examples are few are overcome, reference is provided for low-temperature adsorption separation helium isotope adsorbent screening and system design, development of the He separation and purification technology in China is promoted, and dependence on imported He is reduced.

The invention discloses a composite separation membrane for enriching < 6 > Li isotope and application. The composite separation membrane comprises a functional membrane and at least one supporting membrane; the functional film comprises a plurality of pore channels penetrating through the first surface and the second surface of the functional film, and the pore channel diameter of each pore channel is 0.4-0.7 nm; a lithium ion trapping functional group or a macrocyclic compound and a derivative thereof are modified at an inlet of the first surface of the pore channel. The strength of the lithium isotope separation effect depends on the diameter of a pore channel of the composite separation membrane and functional groups modified at an inlet, does not change along with the migration time and the lithium ion migration proportion, and has long-term continuous stability.

The utility model relates to a gas diffusion cascade device for preparing high-abundance nitrogen-15 isotopes by taking nitrogen as a medium. The gas diffusion cascade device comprises a first gas diffusion cascade, a second gas diffusion cascade, a photocatalysis / electro-catalysis device and a high-speed magnetic suspension gas compressor, the first gas diffusion cascade and the second gas diffusion cascade are ladder cascade and respectively comprise a plurality of gas diffusion separation devices; the photocatalysis / electrocatalysis device is positioned between the first gas diffusion cascade and the second gas diffusion cascade; the high-speed magnetic suspension gas compressor is positioned in front of each gas diffusion and separation device in the nitrogen flowing direction; and obtaining the high-abundance nitrogen-15 isotope prepared by taking nitrogen as a medium from the heavy fraction end of the second gas diffusion cascade. The gas diffusion cascade device is high in separation coefficient, large in flow and high in efficiency, the prepared nitrogen-15 isotope abundance is high, and the gas diffusion cascade device is suitable for industrial application.

The invention relates to the field of heavy water production, and discloses an energy-saving rectification heavy water separation process which comprises the following steps: (1) heating feed water, and carrying out primary rectification; (2) compressing steam at the top of the first-stage rectifying tower, then supplying heat to a first reboiler, performing heat exchange condensation on the compressed steam to form tower top produced liquid for first-stage rectification, enabling one part of the tower top produced liquid to flow back to the first-stage rectifying tower, and discharging the other part of the tower top produced liquid as first-stage rectification distillate; (3) a stripping section base solution of the first-stage rectifying tower flows into a first reboiler, and a part of the stripping section base solution is boiled to form rising steam; the rest part enters a tower kettle and is extracted as heavy water or used as feeding water for next-stage rectification; and (4) carrying out N-stage rectification and purification until the heavy water meets the purity requirement. According to the scheme, the boiling difference between water and heavy water is extremely small, tower top condensation heat is equivalent to a heat source required by a tower kettle, tower top steam is used for providing heat for the tower kettle, latent heat of steam is fully utilized, energy consumption is greatly reduced, and a large number of heat sources can be obtained with a small amount of power consumption.

The invention discloses a preparation method and application of a membrane separation material based on external field enhanced water isotope separation. The preparation method comprises the following steps: firstly, pre-enriching a precursor component containing a polymerizable monomer, a cross-linking agent and a photoinitiator in a confinement pore channel of a nano-porous carrier through an impregnation-encapsulation strategy; and then, through in-situ photo-initiation polymerization, a covalent cross-linked functional polymer network is constructed in the pore channel, and stable packaging of the polymer is realized. In the water isotope separation period, external field conditions are regulated and controlled, the molecular conformation of a polymer chain is accurately controlled, and the separation performance is optimized. According to the invention, by virtue of an external field strengthening technology, the intramolecular / intermolecular interaction is destroyed, and the macromolecular chain is converted from contraction to stretching, so that more functional sites are exposed, and the water isotope separation material designed by the invention has a huge practical application prospect.

Disclosed is a gas separation arrangement for separating and containing various types of gas from a collection chamber based on their different atomic masses. The chamber is connected to an ion diverter via a valve that when open permits the various types of gas to migrate from the collection chamber to an ionizer where the gas is ionized. The ionized gas is accelerated through an ion accelerator and dispensed into an ion deflector. The ion deflector comprises a magnetic field within a channel defined by a pair of split-pole magnets. The trajectory of the ions is based on the mass of the ions, which separates the ions. Multiple collectors are positioned at different locations on an exit side of the ion deflector to receive the different ions traveling along their respective trajectories.

The invention provides a multi-tower series connection method and device for boron isotope separation, and relates to the technical field of isotope separation. According to the multi-tower series connection method for boron isotope separation, four stages of low-temperature rectifying towers which are sequentially connected in series are adopted to achieve low-temperature rectifying separation of boron isotopes at the specific temperature and pressure, tower bottom materials of the previous stage of rectifying tower serve as feeding raw materials of the next stage of rectifying tower, and materials of all stages of rectifying towers are conveyed through pumps; after rectification of the four-stage rectifying tower, a 10BF3 product with abundance greater than 99% can be extracted from the tower bottom of the ultimate rectifying tower; and condensing the gas-phase material at the top of each stage of rectifying tower into liquid through a condenser, extracting the 11BF3 light component, and mixing and collecting the 11BF3 light component through a collecting tank. The method and the device are operated under the normal pressure condition, the boron isotope product can be continuously produced, the energy consumption is low, the production speed is high, the technological operation is simple, no side reaction exists, the product impurity is few, the purity of the boron isotope separated product can be ensured, the cost is low, and the method and the device have good industry prospects.

The invention discloses an ultra-pure gas or isotope separation device based on capillary force driving, and the device comprises a rectification unit which is formed by stacking a plurality of microtubes; the micro-tube rectification unit is arranged in the shell; the diameter of each micropipe is in a range of 0.3 mm-1 mm, and a gas-liquid phase exchange hole is formed in the pipe wall of each micropipe, so that the micropipes provide a liquid phase channel for liquid to flow under the action of capillary force of the micropipes and surface tension of the gas-liquid phase exchange holes in the rectification process of ultra-pure gas or isotope to be rectified; according to the equipment and the system, the rectification unit is small in size and high in heat and mass transfer efficiency, rectification is achieved by horizontally placing the rectification unit, and the requirement for the height space is low.

The invention belongs to the technical field of radioactive isotope separation and purification, and particularly relates to a device for separating and purifying carrier-free lutetium 177. Comprising a mounting rack, a salt transfer assembly arranged in the middle of the front side of the mounting rack, a valve assembly arranged in the middle of the rear side of the mounting rack, a separation and purification column arranged on one side of the salt transfer assembly, a sample injection system arranged on one side of the valve assembly, a fraction assembly arranged above the mounting rack and a waste liquid assembly arranged on one side of the mounting rack, the control terminal is used for controlling the sampling system and the on-off of valves in the valve assembly so as to control the flowing of liquid in the separation and purification device, so that the functions of ytterbium and lutetium separation, lutetium-to-salt concentration and ytterbium-to-salt recovery in the separation and purification device are realized. The problems that in the prior art, an overall device for separating and purifying carrier-free lutetium-177 is large in size and occupied area, the requirement for the automation control degree is high, and the service life of parts is short are solved.

The invention belongs to the technical field of deuterium water treatment, and particularly relates to a preparation method and system of deuterium-depleted water, which is based on combination of an MVR-EDI-air pump and realizes functions through a three-level architecture of pretreatment, gradient separation and deuterium recovery. Comprising a raw water input module, an EDI pure water pretreatment module, a multi-stage MVR evaporation module, a medical water integration module and a deuterium water concentration treatment module, and the raw water input module, the EDI pure water pretreatment module, a primary treatment module, secondary to N-stage treatment modules and the deuterium water concentration treatment module are connected into a whole. By combining filtering purification, low-temperature distillation and a power air energy pump, the production cost is greatly reduced, the deuterium content can be lower than 50 or 30 PPM and further can be lower than 5 PPM, and the water is suitable for medical treatment, aerospace and high-end laboratories; the multi-gradient low-deuterium water production enables deuterium resources to be recycled, and is high in production efficiency, free of wastewater discharge, low in energy consumption and energy-saving.

Disclosed herein are methods and systems for the use of extraction chromatography resins to concentrate Ac from dilute solutions that may contain Th isotopes and / or other isotopes, such as Ra. As disclosed herein, at least some extraction chromatography resins strongly retain trivalent actinides between 4 and 6 M HNO3 that can be recovered in good yields with small volumes of dilute acids. These small volumes of acid eluents result in significant concentration of the solution of the trivalent / certain tetravalent ions, such that they can be further processed without requiring lengthy evaporation steps that are utilized in standard Ac concentration methods.

The invention provides a helium isotope low-temperature adsorption separation system and method, and relates to the technical field of isotope separation. The helium isotope low-temperature adsorption separation system comprises an adsorption column, a low-temperature control unit, an adsorbent regeneration unit, a helium isotope gas outlet control unit, a helium isotope gas inlet and recovery control unit and a system purging replacement unit, the low-temperature control unit comprises a refrigerating machine, a vacuum cover, a first-stage cold screen, a second-stage cold screen, a first-stage anti-radiation screen, a second-stage anti-radiation screen, an air inlet pipe and an air outlet pipe, the first-stage anti-radiation screen is arranged in the vacuum cover, the first-stage cold screen is arranged at an opening of the first-stage anti-radiation screen, and a mounting hole is formed in the first-stage cold screen. The helium isotope low-temperature adsorption separation system provided by the invention has the characteristics of accurate temperature control in a wide temperature area, accurate adsorption pressure control, high rewarming desorption speed, high adsorption efficiency and gas recoverability, is simple in structure and convenient to operate, and has great significance in separation research of helium isotopes.

The invention discloses a dry reboiler for an isotope rectifying tower device. The dry reboiler comprises a porous thin-wall structure and a heating supporting part, wherein the heating supporting part comprises a liquid collecting surface, the porous thin-wall structure is connected with the heating supporting part and located above the liquid collecting surface of the heating supporting part, and the porous thin-wall structure is configured to provide a capillary surface for liquid to flow; liquid on the liquid collecting surface is sucked into the thin wall of the porous thin-wall structure from bottom to top through capillary force, so that gas and liquid flowing in the porous thin-wall structure are subjected to heat and mass transfer; the heating supporting part is provided with a heating rod, the heating supporting part is further configured to transfer heat to the liquid collecting surface of the heating supporting part and the porous thin-wall structure through the heating rod, and the dry type reboiler can reduce the liquid holdup and has the functions of quickly responding to load change, being compact in structure and the like, so that the production requirements of high efficiency, energy conservation and stability are met.

The invention relates to the technical field of isotope separation, and particularly discloses a functionalized ionic liquid as well as a preparation method and application thereof in separation of boron isotopes. The ionic liquid prepared from halogenated ether, a nitrogen-containing compound and fluorine-containing inorganic salt is used as a complexing agent for boron isotope separation. The ionic liquid has good chemical stability and thermal stability and can be kept stable in the long-time separation process of boron isotopes; the ionic liquid has unique selectivity, has different affinity and complexing stability to 10B and 11B, and is convenient to realize accurate separation of 10B and 11B; the boron isotope separation agent also has excellent solubility and flowability, can fully contact and react with boron isotopes, improves the separation efficiency, reduces equipment blockage and energy consumption, and provides convenient conditions for large-scale industrial boron isotope separation; in addition, the ionic liquid has better environmental friendliness, better meets the development requirements of green chemistry, and has huge application potential in the field of boron isotope separation.

Sample introduction system (50) for a spectrometer, comprising: a desolvation chamber (60) configured to obtain or generate sample ions from a solvent matrix and to detach at least a portion of the solvent matrix from the sample ions; a separation chamber (70) downstream of the desolvation chamber (60) and having a separation chamber inlet (72) in fluidic communication with the desolvation chamber (60) to receive the desolvated sample ions along with solvent vapors comprising non-ionized solvent and solvent ions, wherein the separation chamber (70) has electrodes (210, 220) for generating an electric field within the separation chamber (70) that defines a first flow path for sample ions between the separation chamber inlet (72) and a separation chamber outlet (75), but which causes unwanted solvent ions and unwanted non-ionized solvent vapors to be diverted away from the separation chamber outlet (75); and a reaction chamber (80) having an inlet in fluidic communication with the separation chamber outlet (75) to receive the sample ions from the separation chamber (70) and to decompose the received ions into smaller products.

The invention provides a method for separating boron isotopes by using ferroferric oxide / resin microspheres, which comprises the following steps: in a chromatographic column, taking a boric acid-monosodium borate aqueous solution with the pH value of 6-7 as an adsorption solution, and taking a sodium hydroxide aqueous solution with the pH value of 10-11 as a desorption solution to obtain a 10B-rich boric acid aqueous solution; the preparation method of the microspheres comprises the following steps: (1) adding dimethyl sulfoxide to swell polystyrene-divinylbenzene resin microspheres, adding concentrated sulfuric acid to treat until the sulfonation rate is 0.3-0.4 mmol / g, washing with water, treating with an ammonium chloride aqueous solution, washing with water, drying in vacuum, spraying with a ferric chloride-ferrous chloride aqueous solution, evaporating in vacuum to remove part of water, and introducing ammonia-containing nitrogen flow to treat to obtain polystyrene-divinylbenzene resin microspheres; and washing with water, grinding the surface, treating with a sodium hydroxide aqueous solution and washing with water. The method is simple in separation operation, easy to implement and high in efficiency, and has a certain application prospect; the chromatographic column is relatively stable in performance, reproducible and relatively long in service life.

The invention relates to a separation method suitable for At-211 produced by a linear accelerator, which comprises the following steps: performing gradient pressing on bismuth powder and a pore forming agent, and sintering on a porous silicon carbide substrate to form a gradient pore bismuth-silicon carbide composite target material; bombarding the gradient pore bismuth-silicon carbide composite target material through a high-energy particle beam generated by a linear accelerator, and carrying out nuclear reaction on bismuth atoms in the target material to generate At-211; the bombarded target material is pretreated through argon plasma; distilling the pretreated target material under pulse carrier gas to realize volatilization separation of At-211, wherein the carrier gas comprises inert gas, reducing gas and organic acid steam; the distilled gas is subjected to gradient condensation through the micro-channel condenser; and adding an extracting agent into the micro-channel condenser, and dissolving the At-211 in the extracting agent to obtain an At-211 solution. The high-flux separation method of At-211 suitable for linear accelerator production, provided by the invention, is stable, efficient and rapid.

The invention relates to the technical field of tritium extraction and discloses a double-resonance ultrasonic atomizing nozzle, a preparation method and a tritium extraction system.The double-resonance ultrasonic atomizing nozzle comprises a nozzle body and a vibration assembly, the nozzle body is provided with a nozzle opening and a first space for containing liquid metal, and the nozzle opening is communicated with the first space; and the vibration assembly is arranged in the first space, the vibration assembly is provided with at least two vibration ends extending from the first space to the nozzle, each vibration end generates ultrasonic waves through vibration, and every two adjacent vibration ends are arranged in a spaced mode and resonate with each other so that the liquid metal can be atomized. The double-resonance ultrasonic atomizing nozzle solves the technical problem of further strengthening the atomizing effect of lead and lithium liquid drops. According to the double-resonance ultrasonic atomizing nozzle, the atomizing effect of liquid metal can be enhanced, atomized metal liquid drops are more uniform, the dispersion effect of the liquid metal is improved, and the size of the metal liquid drops can be reduced.

The invention provides a high-quality boron isotope separation process and device, the device comprises an exchange rectification system, a complexing system, a complex cracking system and a boron-11 refining system, natural abundance boron trifluoride isotopes are separated through an exchange rectification tower, and cyclic regeneration of boron trifluoride and anisole is realized by adopting the complexing system and the cracking system. A boron-11 refining system is arranged to further improve the abundance of boron-11. According to the method, the industrial continuous production of the high-quality boron trifluoride-10 with the abundance of 99% and the high-quality boron trifluoride-11 with the abundance of 99.9% can be synchronously realized, the process is simple and clear, and the operability is high.

The invention relates to the technical field of hydrogen purification, and discloses a palladium membrane and a preparation method thereof.The method comprises the steps that irradiation treatment is conducted on a palladium-based membrane to obtain the palladium membrane, irradiation ions are adopted to conduct irradiation on at least one surface of the palladium-based membrane in the irradiation treatment, the ion implantation dosage is 1 * 10 < 17 > ions / cm < 2 >-8 * 10 < 17 > ions / cm < 2 >, and the energy of the irradiation ions is 15 keV-2 MeV. The palladium membrane provided by the invention has the advantages of high permeation flux, excellent isotope separation effect, short activation time and stable long-term operation stability.

The invention provides a low-energy-consumption hydrogen isotope separation method and system, and relates to the technical field of hydrogen isotope enrichment. The method comprises the following steps: sequentially carrying out multi-stage rectification on a liquid ammonia raw material to obtain rectified liquid ammonia and a hydrogen isotope compound; the hydrogen isotope compound comprises ND3; a heat source for rectification comprises industrial waste heat. Compared with a conventional method for preparing the isotope from water, the method has the advantages that the liquid ammonia is selected as the raw material based on the reasons of large separation factor, appropriate operation temperature, stable raw material, no corrosion and the like of the liquid ammonia, the hydrogen isotope compound is prepared through multi-stage rectification, and the method is simple to operate, low in investment, high in production capacity, high in product yield and good in economical efficiency.

A mass resolving aperture comprising an aperture body, an open aperture extending through the aperture body from an entry side to an exit side and a scatter recess extending into the entry side of the aperture body and terminating at a recess floor positioned between the entry side and the exit side.

The invention relates to the technical field of metal organic framework materials (MOF) and isotope separation, in particular to a functionalized metal organic framework material for water / heavy water separation and a preparation method and application thereof. The metal organic framework material is a porous crystal material which is formed by coordination self-assembly of metal ions and V-shaped organic ligands and has a periodic network structure; the V-shaped organic ligand is a V-shaped dicarboxylic acid organic ligand modified by an oxygen-containing functional group designed through topological functionalization. According to the metal organic framework material, through topological functional design of a V-shaped organic ligand, a space confinement channel and a high-density oxygen active site are integrated in the same MOF material, and an ideal model system is provided for identification of water isotopes; according to the metal organic framework material, the framework structure flexibility, the pore channel confinement effect and the molecular recognition capability can be synergistically regulated and controlled, so that efficient recognition and separation of water / heavy water are realized.

The invention belongs to the technical field of isotope separation, discloses a device and a method for preparing oxygen 18 and heavy water by using tap water, overcomes the defect of high energy consumption caused by a water rectification method, reduces the production cost, and is suitable for production of nuclear power and civil stable isotope oxygen 18 and heavy water. The device comprises a first large tower, a second large tower, a first tower group, a second tower group, a sixth small tower, a seventh small tower and an eighth small tower which are sequentially connected in series, the first large tower and the second large tower are used for pre-concentrating large-flow tap water entering the towers, and an intermediate material obtained at the bottoms of the towers is conveyed to the first tower group and the second tower group through a pump for moderate concentration; tower bottom concentrate is conveyed to the next-stage rectifying tower to be highly concentrated. According to the method, pre-concentration, primary concentration and concentration enrichment are carried out, intermediate products obtained at the tower bottom converge and enter a next-stage rectifying tower, then high-concentration enrichment is carried out, and finally oxy-18 water and heavy water are obtained.

The invention relates to the technical field of double-temperature water-hydrogen exchange, and provides a double-temperature water-hydrogen exchange device which comprises a first water-hydrogen exchange unit, a second water-hydrogen exchange unit and a gas-liquid separator. Deionized water and deuterium-rich hydrogen react in the first water-hydrogen exchange unit to generate depleted hydrogen and deuterium-rich water, and hydrogen and deuterium-rich water react in the second water-hydrogen exchange unit to generate deuterium-rich hydrogen and depleted water; the gas-liquid separator is provided with a first mixing cavity, a second mixing cavity, a gas collecting cavity, a liquid collecting cavity and a drainage pipeline which are communicated with one another, deuterium-rich water in the first mixing cavity enters the liquid collecting cavity, deuterium-rich hydrogen in the first mixing cavity enters the deuterium-rich hydrogen inlet, the drainage pipeline is used for discharging the deuterium-rich water in the liquid collecting cavity, and deuterium-rich hydrogen in the second mixing cavity enters the gas collecting cavity; and the deuterium-rich water in the second mixing cavity enters the deuterium-rich water inlet. According to the double-temperature water-hydrogen exchange device provided by the embodiment of the invention, the separation effect of deuterium-rich water and deuterium-rich hydrogen can be enhanced, and the production efficiency of the deuterium-rich water is improved.

The invention discloses a system for preparing high-abundance carbon-13 isotope by using carbon tetrafluoride as a medium and a refrigerant, the system comprises a microchannel rectification device, the microchannel rectification device comprises a rectification unit, a reboiler and a condenser, the raw material of the microchannel rectification device is first carbon tetrafluoride with natural abundance, and the second carbon tetrafluoride with natural abundance is a second carbon tetrafluoride with natural abundance; the condenser is configured to condense a component in a gas state in first carbon tetrafluoride to be rectified into liquid, the reboiler is configured to heat the component in the liquid state into gas, and a refrigerant in the condenser is second carbon tetrafluoride. The device adopts a micro-channel rectification mode, so that the height of the rectification tower can be obviously reduced, mass production can be realized, and energy consumption is reduced.

The invention belongs to the field of medical isotope separation and preparation, and particularly relates to a method for separating and purifying < 212 > Pb from a thorium solution, which comprises the following steps: 1) leacheate is introduced into a Pb selective adsorption column to pretreat the Pb selective adsorption column, and then < 232 > Th salt solution and leacheate are introduced in sequence; 2) continuously introducing a desorption solution into the Pb selective adsorption column, enabling the desorption solution passing through the Pb selective adsorption column to flow into the Th selective adsorption column, and collecting the outflowing desorption solution; a desorption solution only containing 212Pb is obtained; according to the method, the 212Pb in the high-concentration thorium solution can be separated and purified at the same time. While < 232 > Th impurity entrainment and pollution in a < 212 > Pb product are remarkably reduced, compared with a single-column process, the separation time is basically not increased. The separated 212Pb product has high radionuclide purity and chemical purity at the same time, and can meet related pharmaceutical requirements.

The invention provides an isotope separation system and an isotope separation method.The isotope separation system comprises a cryogenic temperature and pressure swing adsorption device, the cryogenic temperature and pressure swing adsorption device comprises at least two adsorber units, each adsorber unit comprises a liquid nitrogen container and an adsorber, and in each adsorber unit, the liquid nitrogen container is communicated with the adsorber; the adsorber is soaked in the liquid nitrogen in the liquid nitrogen container; the adsorber comprises a pipe wall, the material of the pipe wall comprises a first material, the constant volume heat capacity Qvh of the unit length of the pipe wall is larger than a first preset value, and the wall thickness D of the pipe wall is 0.5-8 cm; a modified Nusselt criterion # imgabs0 # related to the material and thickness of the tube wall is controlled to be within a predetermined range. The problems of low isotope separation efficiency, poor regeneration effect, high liquid nitrogen consumption and high energy consumption in the prior art are solved, and the cyclic utilization rate of the adsorbent and the heavy component isotope recovery rate are remarkably increased.

An isotope ratio spectrometer is operated for measurement of a sample. First isotope ratios and first signal intensities are measured for a reference in the spectrometer, over a first measurement time period. A first relationship comprising a relationship between the first isotope ratios and the first signal intensities is determined. Sample isotope ratios and sample signal intensities are measured in the spectrometer, over a second measurement time period subsequent to the first measurement time period. Second isotope ratios and second signal intensities for a reference are measured in the spectrometer, over a third measurement time period subsequent to the second measurement time period. A second relationship comprising a relationship between the second isotope ratios and the second signal intensities is determined. A reference isotope ratio is estimated for a time X within the second measurement time period, based on the first relationship and the second relationship.