86 results about "Particle therapy" patented technology

The invention relates to the field of medical equipment, and provides a compact multi-chamber proton treatment system based on a shared beam line, and the system comprises a fixed beam transmission line which is used for guiding the movement direction of a proton beam into a vertical direction; the rotating beam transmission line is used for guiding the movement direction of the proton beam into the horizontal direction; one end of the fixed beam transmission line is connected with the proton cyclotron, the other end of the fixed beam transmission line is connected with one end of the rotary beam transmission line, and the other end of the rotary beam transmission line is in butt joint with a plurality of treatment rooms; the rotating beam transmission line rotates around a central axis extending in the vertical direction. According to the invention, the proton beam can be safely, efficiently and accurately transmitted to each treatment room, and a fixed beam transmission system and a rotating rack do not need to be independently arranged for each treatment room, so that the beam control assembly and the system occupied area of the multi-room particle treatment device are minimized, and the number of treated patients can be remarkably increased.

The invention discloses a multi-angle particle therapy system without a rotating rack and a using method thereof, and relates to the technical field of particle therapy equipment, and the treatment system comprises an accelerator, an irradiation system, a control system, a patient supporting system and an imaging system. The patient supporting system comprises a containing and fixing device, a two-dimensional translation system, a rotating system and a multi-degree-of-freedom mechanical positioning system, the containing and fixing device is connected with the two-dimensional translation system, the two-dimensional translation system is connected with the rotating system, and the two-dimensional translation system controls the relative position of a patient and a rotating center; the rotating system rotates a patient to an appointed angle of a treatment plan or cooperates with the imaging system to obtain a three-dimensional image of the patient, and the irradiation system irradiates a tumor target area; the use method comprises the following steps: generating a treatment plan by reconstructing a three-dimensional CT image, and completing irradiation at different angles according to the treatment plan. According to the treatment system, multi-angle irradiation on a patient can be realized under the condition that a rotating rack is not used, and the manufacturing period and cost of the particle treatment system can be reduced.

An acceleration voltage measurement circuit outputs an acceleration voltage signal Vacc as a measurement signal in which an acceleration radiofrequency voltage excited in the accelerating cavity is measured. A low power radiofrequency control system inputs, to the accelerating cavity, as radiofrequency power, control radiofrequency power at a constant frequency included in the range of the resonance frequency of the accelerating cavity. When the phase difference between the acceleration voltage signal Vacc and the control radiofrequency power becomes within the predetermined value, the low power radiofrequency control system inputs, to the accelerating cavity, as radiofrequency power by feedback control, the acceleration radiofrequency power synchronized with the acceleration frequency that is the frequency of the acceleration voltage signal Vacc, and thereafter, when the acceleration frequency reaches an output frequency Fext, stops the input of the acceleration radiofrequency power to the accelerating cavity.

There is provided a circular accelerator that accelerates a beam of charged particles circulating in a magnetic field such that a closed orbit for each energy of the beam is eccentric. The circular accelerator includes a beam extraction port for extracting beams of different energies from the closed orbit, a first bending magnet and a second bending magnet that bend the beam extracted from the beam extraction port, and a control unit that controls magnetic field strengths of the first bending magnet and the second bending magnet in accordance with the energy of the extracted beam. When the energy of the extracted beam is a designed maximum energy of the circular accelerator, the control unit excites both the first bending magnet and the second bending magnet to bend the beam.

The invention provides a pen-shaped beam model construction method and device in a particle treatment planning system, equipment, a medium and a program product, which can be applied to the technical field of radiotherapy. The pen beam model construction method in the particle therapy planning system comprises the following steps: obtaining integral depth dose measurement data, beam spot measurement data and absolute dose measurement data of particle therapy equipment in the particle therapy planning system; respectively constructing an integral depth dose model, a beam spot model and an absolute dose model based on the integral depth dose measurement data, the beam spot measurement data and the absolute dose measurement data, and forming a pen beam model of the particle therapy equipment; performing simulation verification on the pen-shaped beam model, and adjusting corresponding parameters in the pen-shaped beam model according to difference data between simulation data and actual measurement data; and generating at least one quality assurance plan of the adjusted pen-shaped beam model under the condition that the adjusted pen-shaped beam model meets a preset error condition.

The invention relates to the field of medical resource scheduling, in particular to a multi-chamber particle therapy method, system and device, a storage medium and a computer storage medium, and the system comprises an irradiation source which is used for generating a particle beam; the plurality of particle treatment rooms are used for sending beam requests and receiving the particle beams; the beam transport device is used for transmitting the particle beam from the irradiation source to the particle treatment room; and the control device is used for receiving the beam requests of the particle treatment room, calculating the priority for each beam request according to the reserved irradiation time, the tumor type and the patient condition included in each beam request, and controlling the beam transport device to transport the particle beams according to the priorities. According to the method, the utilization efficiency of beam resources can be remarkably improved, the urgency degree and clinical importance of treatment are fully considered, and the demand intensity of different requests for the beam resources can be quantitatively reflected.

The invention relates to the technical field of particle therapy, and provides a vacuum membrane window structure and a processing method.The structure comprises a membrane window flange, a supporting lining net, a non-metal polymer film, a membrane window pressing plate, a first sealing piece and a second sealing piece; the membrane window flange is provided with an annular positioning part; the supporting lining net is arranged on the annular positioning part; the non-metal polymer film is arranged on the side, away from the annular positioning part, of the supporting lining net and plated with a metal layer. The film window pressing plate is arranged on the side, away from the supporting lining net, of the non-metal polymer film. The first sealing piece is arranged between the periphery of the supporting lining net and the non-metal polymer film, and the second sealing piece is arranged between the periphery of the annular positioning part and the periphery of the non-metal polymer film; the non-metal polymer film, the film plating layer and the supporting lining net are tightly attached together, so that the film thickness is greatly reduced, the vacuum performance of a single-layer film is better than that of an existing double-layer structure, energy loss, scattering and neutron yield during beam film penetrating are reduced, and beam quality and treatment precision are improved.

An accelerator capable of efficiently and satisfactorily extracting a beam is provided. A main magnet A101 applies a main magnetic field to a space between a plurality of main magnetic poles M202 arranged to face each other. An RF kicker M204 causes a beam circulating in a main magnetic field region to which the main magnetic field is applied to be displaced to outside of the main magnetic field region. An extraction channel magnetic field to extract the beam is generated. A canceling magnetic field generation device M214 is provided to be closer to an inner peripheral side than an extraction channel M207 and generates a canceling magnetic field with a polarity opposite to that of a disturbance magnetic field produced by an extraction channel.

The present application belongs to the technical field of high-end medical equipment. Disclosed are a multi-room particle therapy room, a radiotherapy system, and a particle accelerator movement method. The multi-room particle therapy room comprises a plurality of treatment rooms. The radiotherapy system comprises the multi-room particle therapy room and a particle accelerator. Each treatment room is provided with a beam window. The particle accelerator can move outside different treatment rooms and is aligned with the beam windows. The particle accelerator directs particle beams into the treatment rooms by means of the beam windows. The particle beams perform radiotherapy by means of therapy heads in the treatment rooms. The radiotherapy system is not provided with a dipole magnet or a quadrupole magnet. The plurality of treatment rooms share one particle accelerator. The particle accelerator is moved to the outside of the treatment room requiring the particle beam, and the particle beam is directed into the treatment room by means of the beam window. When the treatment in the treatment room is completed, the particle accelerator is moved to other treatment rooms requiring the particle beams and performs treatment work, thereby reducing the overall cost of the radiotherapy system and making proton therapy accessible.

The invention discloses a rotary particle treatment head curtain sealing structure, and belongs to the technical field of proton therapy, the rotary particle treatment head curtain sealing structure comprises a hollow rack and a telescopic particle treatment head, the inner side of the rack is provided with a C-shaped mounting port, the particle treatment head is rotatably arranged in the mounting port, the rack is internally provided with a C-shaped first track, and the first track is provided with a second track. And a C-shaped second rail is fixedly arranged between the two ends of the first rail. According to the rotary particle treatment head curtain sealing structure, the sliding frame on the first track is matched with the curtain to seal the particle treatment head and the rack, the second track is matched with the first track to enable the sliding frame to move along with rotation of the particle treatment head, and dust on the curtain is cleaned through the dust collection assembly at the second track. Compared with an existing device, the problem that dust falls into and is accumulated in a gap between the particle treatment head and the rack is solved, the stability of the device is improved, and the service life of the device is prolonged.

This application discloses a multi-angle particle therapy system without a rotating gantry and its use method, relating to the technical field of particle therapy equipment. The system comprises an accelerator, an irradiation system, a control system, a patient support system, and an imaging system. The patient support system includes a holding fixture, a two-dimensional translation system, a rotation system, and a multi-degree-of-freedom mechanical positioning system. The holding fixture is connected to the two-dimensional translation system, which in turn is connected to the rotation system. The two-dimensional translation system controls the relative position of the patient and the rotation center. The rotation system rotates the patient to the angle specified in the treatment plan or cooperates with the imaging system to obtain a three-dimensional image of the patient. The irradiation system irradiates the target tumor area. The system generates a treatment plan by reconstructing a three-dimensional CT image and then performs irradiation at different angles according to the treatment plan. This system can achieve multi-angle irradiation of the patient without the use of a rotating gantry, reducing the manufacturing cycle and cost of the particle therapy system.

The utility model belongs to the technical field of treatment auxiliary equipment, and discloses supporting and positioning equipment for patient treatment and a particle treatment system. The movable mechanism is connected with the bearing component so as to movably adjust the bearing component, and the movable mechanism comprises two groups of multidirectional adjusting mechanisms which are symmetrically connected to two end sides of the bearing component respectively; and the counterweight adjusting assembly is arranged on the movable mechanism. The auxiliary positioning device can effectively replace traditional auxiliary positioning equipment which is complex in structure and high in cost, can achieve multi-angle adjustment on the body position or the target area of the body of a patient, can guarantee the adjustment accuracy in the treatment process, has the outstanding advantages of being compact in structure, small in size, low in manufacturing cost, easy and convenient to maintain and the like, and is suitable for popularization and application. And particularly, a rotary rack and a six-dimensional robot can be replaced on the premise of ensuring the treatment precision in particle treatment.

To implement downsizing of an apparatus and highly accurate beam irradiation. An irradiation nozzle 4 that irradiates a target object Pt with a radiotherapy beam includes: a nozzle base part 42 fixed on a beam axis 40 through which the radiotherapy beam passes; and a nozzle tip part that irradiates the target object with the radiotherapy beam that has passed through the nozzle base part, in which the nozzle tip part is fixed at a first position when the target object is irradiated with the radiotherapy beam and is fixed at a second position when the target object is imaged, and a curved movement path in which the nozzle tip part is movable between the first position and the second position is provided.

The invention discloses a PET imaging device for multi-radiation-field particle therapy, PET equipment and a therapy system. The PET imaging device comprises: an identification unit configured to identify one or more time intervals of each radiation field according to time distribution characteristics of collected single event data, each time interval corresponding to a particle beam delivery state; the coincidence processing unit is configured to perform coincidence processing on the single event data to generate coincidence event data; and the reconstruction unit is configured to perform image reconstruction on the coincidence event data in the identified time interval of each radiation field to obtain a reconstructed image corresponding to each radiation field. Through intelligent identification of time distribution characteristics and a partition reconstruction strategy, the problem of serious aliasing of PET signals in a multi-radiation-field delivery mode is solved, and accurate extraction of independent dose distribution of each radiation field and image reconstruction are realized.

The present disclosure relates to methods of selecting a treatment regimen for a subject having cancer (e.g., prostate cancer) by determining the presence of a mutation in the subject's tumor that makes the subject a candidate for particle therapy. Methods of treating the subject and determining relative dosage are also contemplated herein.

The present disclosure relates to an automated device and methods to produce a highly purified alpha-emitting radioisotope Pb-212 from a pre-filled column of a parent isotope Ra-224 for use in targeted alpha-particle therapy.

1. The name of the design product: dose simulation simulation device. 2. The use of the design product: for simulating beam current signals generated by an accelerator in a particle therapy system. 3. The design features of the design product: in shape. 4. The picture or photo that best indicates the design features: perspective view.

The present application relates to the technical field of tumor radiotherapy and magnetic induction hyperthermia medical devices, and discloses a composite particle magnetic hyperthermia-radiotherapy system implanted via a soft ultrasonic endoscope, comprising a soft ultrasonic endoscope, a puncture needle sliding in a working channel of the soft ultrasonic endoscope, one end of the puncture needle being connected to a particle channel, the particle channel being loaded with composite particles; a propulsion needle pushing the composite particles in the particle channel to the puncture needle; the present application can sequentially implant composite particles, so that it can have magnetic hyperthermia and radiotherapy effects, synergistically enhance sensitivity, and can more efficiently kill diseased tissues and improve treatment effects; and the system is guided by a soft ultrasonic endoscope and intervenes through natural cavities to puncture and implant composite particles in malignant tumors in human cavities such as the digestive tract, thereby broadening the application scenarios of magnetic hyperthermia and radioactive particle therapy; due to the self-temperature-control characteristics of the composite particles, the system does not require a temperature measurement and control device, thereby reducing the complexity of the equipment while ensuring the targeting, safety and efficacy of tumor treatment.

The invention relates to the technical field of malignant tumor treatment equipment, and discloses a scintillator excitation sensitizer system applied to malignant tumor 125 iodine particle treatment. Comprising a three-dimensional modeling module used for obtaining imaging data of tumor tissues and constructing a three-dimensional model; the radiation prediction module is used for calculating radiation dose rate space-time distribution around each radiator based on the 125 iodine particle cylinder radiator model, and forming an overall radiation dose rate space-time distribution prediction model through superposition; the positioning calculation module is used for determining the optimal placement position of the scintillator in the tumor tissue in combination with the three-dimensional model and the radiation dose rate space-time distribution prediction model; and the guiding module is used for generating a scintillator implantation path and guiding the puncture device to accurately implant the scintillator into the optimal implantation position. The optimal positioning of the scintillator in the tumor is realized, and the key problems of low-energy gamma ray energy conversion efficiency and safety are solved.

The application relates to a rotating volume intensity modulated particle therapy optimization system for a superconducting gantry, comprising: a data setting module configured to set optimization input data; an equation construction module configured to construct an augmented Lagrange equation, and replace an original optimization problem into an iterative form combined with an alternating direction multiplier method; an iterative optimization module configured to perform alternating direction multiplier method iterative optimization, and solve corresponding point array weights under the condition of meeting constraint conditions; a threshold pruning module configured to perform threshold pruning on the point array weights, and eliminate non-active points to obtain new point array weights; a condition judgment module configured to judge whether a set convergence condition is reached, and if not, repeat the setting step; and an optimization output module configured to output the point array weights and energy layer dose distribution proportions. The application reduces non-active point irradiation, significantly enhances the sparsity of scanning points in a selected energy segment, and adapts to the rapid energy conversion of the superconducting gantry in a large momentum acceptance energy segment.

The present invention discloses a programmable weak charge generating device, a generating method and related equipment, and relates to the field of particle therapy technology. The device includes: an FPGA control unit, a current source, a programmable current source regulating unit and a feedback unit; the FPGA control unit is electrically connected to the programmable current source regulating unit; the FPGA control unit is electrically connected to the feedback unit; according to a compensation algorithm, the FPGA determines a control signal according to a feedback signal from the feedback unit; the programmable current source regulating unit receives the control signal, regulates the current, and controls the pulse width of the current source. By combining the FPGA control circuit with the compensation method, the accuracy of the weak signal output is greatly improved, and the output accuracy reaches at least 1pC charge. In addition, the circuit design analysis is combined with a mathematical model to flexibly, conveniently, quickly and accurately adaptively compensate for the error of the signal source, thereby achieving precise control of the output charge.

To provide an ion source which enables cooling and gas supply to a discharge chamber to be made compatible with each other by compact configuration, and to provide a circular accelerator and a particle-beam radiation therapy system.SOLUTION: An ion source comprises: a cathode 33; cathode support equipment 35 which supports the cathode 33 and supplies voltage to the cathode; cooling pipes 24, 25 which cool the cathode support equipment 35; and gas supply flow channels 22, 22A, 22B, 22C, 22D which supply gas to a discharge chamber 36. The cooling pipes 24, 25 are arranged on the inner side of the gas supply flow channels 22, 22A, 22B, 22C, 22D.SELECTED DRAWING: Figure 4

As the ion beam is accelerated, the radii of the closed orbits gradually increase, and the centers thereof move in a direction approaching the peripheral edge portion along a predetermined radial direction of the cavity, and upon reversing the direction of movement, move further toward the center of the cavity. The intensity distribution in the orbital plane of the main magnetic field is designed to realize the foregoing feature. Thus, an accelerator is provided that is compact and that enables the energy of an extracted beam to be changed, that enhances the efficiency of beam injection into the accelerator from an external ion source, and that improves a dose rate of the resulting extracted ion beam.

To provide a rotary capacitor which can stabilize frequency modulation while increasing the life of a component.SOLUTION: A rotary capacitor 22 includes: an external conductor 15 covering a stator electrode 32 and a rotor electrode 33; and a bypass capacitor 23 for electrostatically combining the rotor electrode 33 and an external conductor 15 to each other. An electrode pair of the bypass capacitors 23 (an external conductor side electrode 24 and a rotor side electrode 25) are set to extend along the direction of the axis of rotation of the rotor electrode 33 in the outer periphery side of a metal shaft part 35a. Also, at least one of the electrode pair of the bypass capacitor 23 has a cylindrical shape.SELECTED DRAWING: Figure 4

A circular accelerator (30) is a device that applies a static magnetic field that circulates a charged particle beam, a radio frequency acceleration electric field that is frequency-modulated and accelerates the charged particle beam, and a radio frequency disturbance electric field that extracts the charged particle beam, in which a circulation frequency of the charged particle beam circulating inside the circular accelerator (30) or kinetic energy of the charged particle beam is obtained after stopping the radio frequency acceleration electric field, and the radio frequency disturbance electric field is generated according to the obtained circulation frequency or kinetic energy. As a result, an accelerator and a particle therapy apparatus capable of improving beam utilization efficiency as compared with the related art are provided.

Disclosed herein are conjugates comprising an alpha particle emitter and an anti-cancer agent, compositions comprising the conjugate, kits for radiolabeling with an alpha particle emitter and an anti-cancer agent, and a method of using the conjugate to treat cancer. The alpha-particle emitter and the anti-cancer agent may be unmodified or linked to each other with a chelating agent.

The application discloses a PET imaging device, a PET device and a treatment system for multi-field particle therapy. The PET imaging device comprises: an identification unit configured to identify one or more time intervals of each field according to a time distribution feature of acquired single-event data, each time interval corresponding to a particle beam delivery state; a coincidence processing unit configured to perform coincidence processing on the single-event data to generate coincidence event data; and a reconstruction unit configured to perform image reconstruction on the coincidence event data in the identified time intervals of each field to obtain a corresponding reconstructed image of each field. Through intelligent identification of the time distribution feature and a partition reconstruction strategy, the application solves the problem of serious overlap of PET signals in a multi-field delivery mode, and realizes accurate extraction of independent dose distribution of each field and image reconstruction.

A particle therapy device according to the present invention comprises an irradiation unit that irradiates a particle beam at an irradiation target, a rotating gantry that supports the irradiation unit such that the irradiation unit can rotate around the irradiation target, and a magnetic resonance imaging unit that is provided to the rotating gantry and acquires an image of the irradiation target by means of magnetic fields. To acquire a desired cross-sectional image regardless of the rotation of the rotating gantry, the magnetic resonance imaging unit: has a gradient magnetic field generation unit that generates a gradient magnetic field in each of three axial directions; can apply gradient magnetic fields for at least two axes at the same time; and acquires a cross-sectional image for a desired stationary coordinate system by superimposing vectors for the gradient magnetic fields from the gradient magnetic field generation unit for the different axes on the basis of the rotation angle of the rotating gantry.

An example particle therapy system can include a synchrocyclotron to generate a particle beam, a scanner to move the particle beam in one or more dimensions relative to an irradiation target, and an energy degrader between the scanner and the irradiation target. The energy degrader can include a plurality of plates that are movable relative to a path of the particle beam and each controllable to move in the path of the particle beam and during movement of the particle beam. An aperture can be between the energy degrader and the irradiation target. The aperture can trim the particle beam before the particle beam reaches the irradiation target.

This invention provides a real-time detection system and method for particle therapy beam irradiation depth. The real-time detection system includes a position-sensitive ionization chamber, a dose ionization chamber, and a data acquisition and processing module. The position-sensitive ionization chamber is located on one side of the patient's target area and on the beam side, and is used to measure the intensity of the radiation field generated near the patient's target area. The dose ionization chamber is located upstream of the isocenter and perpendicular to the beam injection direction, and is used to measure the beam intensity. The data acquisition and processing module is electrically connected to both the position-sensitive ionization chamber and the dose ionization chamber. Compared with existing technologies, this invention can simultaneously monitor the beam intensity and measure the irradiation depth of the ion beam in real time. It can be used for real-time feedback of irradiation depth during proton and carbon ion therapy, protecting the patient's normal organs and reducing the impact of depth uncertainty factors on the treatment effect.