62 results about "Particle therapy" patented technology

The invention relates to the field of medical resource scheduling, in particular to a multi-chamber particle therapy method, system and device, a storage medium and a computer storage medium, and the system comprises an irradiation source which is used for generating a particle beam; the plurality of particle treatment rooms are used for sending beam requests and receiving the particle beams; the beam transport device is used for transmitting the particle beam from the irradiation source to the particle treatment room; and the control device is used for receiving the beam requests of the particle treatment room, calculating the priority for each beam request according to the reserved irradiation time, the tumor type and the patient condition included in each beam request, and controlling the beam transport device to transport the particle beams according to the priorities. According to the method, the utilization efficiency of beam resources can be remarkably improved, the urgency degree and clinical importance of treatment are fully considered, and the demand intensity of different requests for the beam resources can be quantitatively reflected.

The invention relates to the technical field of particle therapy, and provides a vacuum membrane window structure and a processing method.The structure comprises a membrane window flange, a supporting lining net, a non-metal polymer film, a membrane window pressing plate, a first sealing piece and a second sealing piece; the membrane window flange is provided with an annular positioning part; the supporting lining net is arranged on the annular positioning part; the non-metal polymer film is arranged on the side, away from the annular positioning part, of the supporting lining net and plated with a metal layer. The film window pressing plate is arranged on the side, away from the supporting lining net, of the non-metal polymer film. The first sealing piece is arranged between the periphery of the supporting lining net and the non-metal polymer film, and the second sealing piece is arranged between the periphery of the annular positioning part and the periphery of the non-metal polymer film; the non-metal polymer film, the film plating layer and the supporting lining net are tightly attached together, so that the film thickness is greatly reduced, the vacuum performance of a single-layer film is better than that of an existing double-layer structure, energy loss, scattering and neutron yield during beam film penetrating are reduced, and beam quality and treatment precision are improved.

An accelerator capable of efficiently and satisfactorily extracting a beam is provided. A main magnet A101 applies a main magnetic field to a space between a plurality of main magnetic poles M202 arranged to face each other. An RF kicker M204 causes a beam circulating in a main magnetic field region to which the main magnetic field is applied to be displaced to outside of the main magnetic field region. An extraction channel magnetic field to extract the beam is generated. A canceling magnetic field generation device M214 is provided to be closer to an inner peripheral side than an extraction channel M207 and generates a canceling magnetic field with a polarity opposite to that of a disturbance magnetic field produced by an extraction channel.

The present application belongs to the technical field of high-end medical equipment. Disclosed are a multi-room particle therapy room, a radiotherapy system, and a particle accelerator movement method. The multi-room particle therapy room comprises a plurality of treatment rooms. The radiotherapy system comprises the multi-room particle therapy room and a particle accelerator. Each treatment room is provided with a beam window. The particle accelerator can move outside different treatment rooms and is aligned with the beam windows. The particle accelerator directs particle beams into the treatment rooms by means of the beam windows. The particle beams perform radiotherapy by means of therapy heads in the treatment rooms. The radiotherapy system is not provided with a dipole magnet or a quadrupole magnet. The plurality of treatment rooms share one particle accelerator. The particle accelerator is moved to the outside of the treatment room requiring the particle beam, and the particle beam is directed into the treatment room by means of the beam window. When the treatment in the treatment room is completed, the particle accelerator is moved to other treatment rooms requiring the particle beams and performs treatment work, thereby reducing the overall cost of the radiotherapy system and making proton therapy accessible.

This application discloses a multi-angle particle therapy system without a rotating gantry and its use method, relating to the technical field of particle therapy equipment. The system comprises an accelerator, an irradiation system, a control system, a patient support system, and an imaging system. The patient support system includes a holding fixture, a two-dimensional translation system, a rotation system, and a multi-degree-of-freedom mechanical positioning system. The holding fixture is connected to the two-dimensional translation system, which in turn is connected to the rotation system. The two-dimensional translation system controls the relative position of the patient and the rotation center. The rotation system rotates the patient to the angle specified in the treatment plan or cooperates with the imaging system to obtain a three-dimensional image of the patient. The irradiation system irradiates the target tumor area. The system generates a treatment plan by reconstructing a three-dimensional CT image and then performs irradiation at different angles according to the treatment plan. This system can achieve multi-angle irradiation of the patient without the use of a rotating gantry, reducing the manufacturing cycle and cost of the particle therapy system.

The utility model belongs to the technical field of treatment auxiliary equipment, and discloses supporting and positioning equipment for patient treatment and a particle treatment system. The movable mechanism is connected with the bearing component so as to movably adjust the bearing component, and the movable mechanism comprises two groups of multidirectional adjusting mechanisms which are symmetrically connected to two end sides of the bearing component respectively; and the counterweight adjusting assembly is arranged on the movable mechanism. The auxiliary positioning device can effectively replace traditional auxiliary positioning equipment which is complex in structure and high in cost, can achieve multi-angle adjustment on the body position or the target area of the body of a patient, can guarantee the adjustment accuracy in the treatment process, has the outstanding advantages of being compact in structure, small in size, low in manufacturing cost, easy and convenient to maintain and the like, and is suitable for popularization and application. And particularly, a rotary rack and a six-dimensional robot can be replaced on the premise of ensuring the treatment precision in particle treatment.

To implement downsizing of an apparatus and highly accurate beam irradiation. An irradiation nozzle 4 that irradiates a target object Pt with a radiotherapy beam includes: a nozzle base part 42 fixed on a beam axis 40 through which the radiotherapy beam passes; and a nozzle tip part that irradiates the target object with the radiotherapy beam that has passed through the nozzle base part, in which the nozzle tip part is fixed at a first position when the target object is irradiated with the radiotherapy beam and is fixed at a second position when the target object is imaged, and a curved movement path in which the nozzle tip part is movable between the first position and the second position is provided.

The invention discloses a PET imaging device for multi-radiation-field particle therapy, PET equipment and a therapy system. The PET imaging device comprises: an identification unit configured to identify one or more time intervals of each radiation field according to time distribution characteristics of collected single event data, each time interval corresponding to a particle beam delivery state; the coincidence processing unit is configured to perform coincidence processing on the single event data to generate coincidence event data; and the reconstruction unit is configured to perform image reconstruction on the coincidence event data in the identified time interval of each radiation field to obtain a reconstructed image corresponding to each radiation field. Through intelligent identification of time distribution characteristics and a partition reconstruction strategy, the problem of serious aliasing of PET signals in a multi-radiation-field delivery mode is solved, and accurate extraction of independent dose distribution of each radiation field and image reconstruction are realized.

The present disclosure relates to methods of selecting a treatment regimen for a subject having cancer (e.g., prostate cancer) by determining the presence of a mutation in the subject's tumor that makes the subject a candidate for particle therapy. Methods of treating the subject and determining relative dosage are also contemplated herein.

The present disclosure relates to an automated device and methods to produce a highly purified alpha-emitting radioisotope Pb-212 from a pre-filled column of a parent isotope Ra-224 for use in targeted alpha-particle therapy.

1. The name of the design product: dose simulation simulation device. 2. The use of the design product: for simulating beam current signals generated by an accelerator in a particle therapy system. 3. The design features of the design product: in shape. 4. The picture or photo that best indicates the design features: perspective view.

The invention relates to the technical field of malignant tumor treatment equipment, and discloses a scintillator excitation sensitizer system applied to malignant tumor 125 iodine particle treatment. Comprising a three-dimensional modeling module used for obtaining imaging data of tumor tissues and constructing a three-dimensional model; the radiation prediction module is used for calculating radiation dose rate space-time distribution around each radiator based on the 125 iodine particle cylinder radiator model, and forming an overall radiation dose rate space-time distribution prediction model through superposition; the positioning calculation module is used for determining the optimal placement position of the scintillator in the tumor tissue in combination with the three-dimensional model and the radiation dose rate space-time distribution prediction model; and the guiding module is used for generating a scintillator implantation path and guiding the puncture device to accurately implant the scintillator into the optimal implantation position. The optimal positioning of the scintillator in the tumor is realized, and the key problems of low-energy gamma ray energy conversion efficiency and safety are solved.

The application relates to a rotating volume intensity modulated particle therapy optimization system for a superconducting gantry, comprising: a data setting module configured to set optimization input data; an equation construction module configured to construct an augmented Lagrange equation, and replace an original optimization problem into an iterative form combined with an alternating direction multiplier method; an iterative optimization module configured to perform alternating direction multiplier method iterative optimization, and solve corresponding point array weights under the condition of meeting constraint conditions; a threshold pruning module configured to perform threshold pruning on the point array weights, and eliminate non-active points to obtain new point array weights; a condition judgment module configured to judge whether a set convergence condition is reached, and if not, repeat the setting step; and an optimization output module configured to output the point array weights and energy layer dose distribution proportions. The application reduces non-active point irradiation, significantly enhances the sparsity of scanning points in a selected energy segment, and adapts to the rapid energy conversion of the superconducting gantry in a large momentum acceptance energy segment.

The present invention discloses a programmable weak charge generating device, a generating method and related equipment, and relates to the field of particle therapy technology. The device includes: an FPGA control unit, a current source, a programmable current source regulating unit and a feedback unit; the FPGA control unit is electrically connected to the programmable current source regulating unit; the FPGA control unit is electrically connected to the feedback unit; according to a compensation algorithm, the FPGA determines a control signal according to a feedback signal from the feedback unit; the programmable current source regulating unit receives the control signal, regulates the current, and controls the pulse width of the current source. By combining the FPGA control circuit with the compensation method, the accuracy of the weak signal output is greatly improved, and the output accuracy reaches at least 1pC charge. In addition, the circuit design analysis is combined with a mathematical model to flexibly, conveniently, quickly and accurately adaptively compensate for the error of the signal source, thereby achieving precise control of the output charge.

To provide an ion source which enables cooling and gas supply to a discharge chamber to be made compatible with each other by compact configuration, and to provide a circular accelerator and a particle-beam radiation therapy system.SOLUTION: An ion source comprises: a cathode 33; cathode support equipment 35 which supports the cathode 33 and supplies voltage to the cathode; cooling pipes 24, 25 which cool the cathode support equipment 35; and gas supply flow channels 22, 22A, 22B, 22C, 22D which supply gas to a discharge chamber 36. The cooling pipes 24, 25 are arranged on the inner side of the gas supply flow channels 22, 22A, 22B, 22C, 22D.SELECTED DRAWING: Figure 4

As the ion beam is accelerated, the radii of the closed orbits gradually increase, and the centers thereof move in a direction approaching the peripheral edge portion along a predetermined radial direction of the cavity, and upon reversing the direction of movement, move further toward the center of the cavity. The intensity distribution in the orbital plane of the main magnetic field is designed to realize the foregoing feature. Thus, an accelerator is provided that is compact and that enables the energy of an extracted beam to be changed, that enhances the efficiency of beam injection into the accelerator from an external ion source, and that improves a dose rate of the resulting extracted ion beam.

Disclosed herein are conjugates comprising an alpha particle emitter and an anti-cancer agent, compositions comprising the conjugate, kits for radiolabeling with an alpha particle emitter and an anti-cancer agent, and a method of using the conjugate to treat cancer. The alpha-particle emitter and the anti-cancer agent may be unmodified or linked to each other with a chelating agent.

The application discloses a PET imaging device, a PET device and a treatment system for multi-field particle therapy. The PET imaging device comprises: an identification unit configured to identify one or more time intervals of each field according to a time distribution feature of acquired single-event data, each time interval corresponding to a particle beam delivery state; a coincidence processing unit configured to perform coincidence processing on the single-event data to generate coincidence event data; and a reconstruction unit configured to perform image reconstruction on the coincidence event data in the identified time intervals of each field to obtain a corresponding reconstructed image of each field. Through intelligent identification of the time distribution feature and a partition reconstruction strategy, the application solves the problem of serious overlap of PET signals in a multi-field delivery mode, and realizes accurate extraction of independent dose distribution of each field and image reconstruction.

An example particle therapy system can include a synchrocyclotron to generate a particle beam, a scanner to move the particle beam in one or more dimensions relative to an irradiation target, and an energy degrader between the scanner and the irradiation target. The energy degrader can include a plurality of plates that are movable relative to a path of the particle beam and each controllable to move in the path of the particle beam and during movement of the particle beam. An aperture can be between the energy degrader and the irradiation target. The aperture can trim the particle beam before the particle beam reaches the irradiation target.

This invention provides a real-time detection system and method for particle therapy beam irradiation depth. The real-time detection system includes a position-sensitive ionization chamber, a dose ionization chamber, and a data acquisition and processing module. The position-sensitive ionization chamber is located on one side of the patient's target area and on the beam side, and is used to measure the intensity of the radiation field generated near the patient's target area. The dose ionization chamber is located upstream of the isocenter and perpendicular to the beam injection direction, and is used to measure the beam intensity. The data acquisition and processing module is electrically connected to both the position-sensitive ionization chamber and the dose ionization chamber. Compared with existing technologies, this invention can simultaneously monitor the beam intensity and measure the irradiation depth of the ion beam in real time. It can be used for real-time feedback of irradiation depth during proton and carbon ion therapy, protecting the patient's normal organs and reducing the impact of depth uncertainty factors on the treatment effect.

A beam delivery system for particle therapy is provided, which when combined with an appropriate patient positioning system, can effectively replace the large and cumbersome gantry systems traditionally used in particle therapy for example for treatment of cancer or other diseased tissue conditions. The system's modular design enables scalability, making particle therapy more accessible and affordable for a broader range of healthcare facilities and patients.

A rotating capacitor is used in a circular accelerator that accelerates a charged particle beam by feeding a first radio frequency to a DC main magnetic field. The rotating capacitor modulates a frequency of the first radio frequency. The rotating capacitor includes a stator electrode and a rotor electrode used for modulating the frequency of the first radio frequency together with the stator electrode. A vacuum seal performs vacuum sealing around a shaft for rotating the rotor electrode. A bearing that supports the shaft is installed on an atmosphere side.

Described herein are compact particle therapy systems comprising a superconducting cyclotron for proton therapy applications. In some aspects, an electromagnetic beamline incorporating energy selection systems and pencil beam scanning magnets directs particle beams from the cyclotron to a treatment isocenter. A patient positioning device comprising a robotic positioner with six degrees of freedom supports patient alignment, t. The particle system can be ultra compact and able to be installed in existing photon linear accelerator (e.g., radiation therapy) vaults.

An object of the present invention is to speed up an operation of extracting an ion beam from an accelerator. An accelerator 100 includes an upper magnetic pole 8 and a lower magnetic pole 9 sandwiching an ion circulation space 10 in which ions circulate. At least one of the upper magnetic pole 8 and the lower magnetic pole 9 is formed such that a magnetic pole interval between the upper magnetic pole 8 and the lower magnetic pole 9 varies when the ion circulation space 10 is viewed along an ion beam trajectory. That is, a wide interval region 11 having a larger magnetic pole interval than a peripheral region is formed in a region closer to a center point of the ion circulation space 10 than a center point of the ion beam trajectory.

The present application relates to the technical field of particle therapy, and provides a vacuum film window structure and a processing method.The structure comprises a film window flange, a support mesh, a non-metallic polymer film, a film window pressing plate, a first sealing element and a second sealing element.The film window flange is provided with an annular positioning portion.The support mesh is arranged on the annular positioning portion.The non-metallic polymer film is arranged on one side of the support mesh away from the annular positioning portion, and the non-metallic polymer film is plated with a metal layer.The film window pressing plate is arranged on one side of the non-metallic polymer film away from the support mesh.The first sealing element is arranged between the periphery of the support mesh and the non-metallic polymer film, and the second sealing element is arranged between the periphery of the annular positioning portion and the periphery of the non-metallic polymer film.The non-metallic polymer film, the film plating layer and the support mesh are tightly adhered together, so that the film thickness is greatly reduced, the vacuum performance of the single-layer film is better than that of the existing double-layer structure, the energy loss, scattering and neutron yield when the beam passes through the film are reduced, and the beam quality and treatment accuracy are improved.

The utility model discloses a rotary particle treatment head curtain sealing structure, which belongs to the technical field of proton therapy, and comprises a hollow rack and a telescopic particle treatment head, a C-shaped mounting port is arranged on the inner side of the rack, the particle treatment head is rotatably arranged in the mounting port, a C-shaped first track is arranged in the rack, and a second track is arranged in the rack. And a C-shaped second rail is fixedly arranged between the two ends of the first rail. According to the rotary particle treatment head curtain sealing structure, the sliding frame on the first track is matched with the curtain to seal the particle treatment head and the rack, the second track is matched with the first track to enable the sliding frame to move along with rotation of the particle treatment head, and dust on the curtain is cleaned through the dust collection assembly at the second track. Compared with an existing device, the problem that dust falls into and is accumulated in a gap between the particle treatment head and the rack is solved, the stability of the device is improved, and the service life of the device is prolonged.

The invention belongs to the field of particle therapy, and discloses a multi-angle particle therapy system and a control method thereof.The multi-angle particle therapy system comprises a particle beam system, a bearing component, a multi-direction adjusting mechanism, a balance weight adjusting assembly and a control system.On the premise of not depending on a traditional large rotating rack and a six-dimensional robot therapy couch, the multi-angle particle therapy system can achieve multi-angle particle therapy; the multi-angle particle beam irradiation device achieves multi-angle particle beam irradiation on a target area of a patient, guarantees treatment precision, and meanwhile has the outstanding advantages of being compact in structure, small in size, low in manufacturing cost, easy and convenient to maintain and the like.

This application discloses a PET imaging method, electronic device, and storage medium for multi-field particle therapy. The PET imaging method includes: identifying one or more time intervals for each field based on the temporal distribution characteristics of acquired single-event data, with each time interval corresponding to a particle beam delivery state; performing conformation processing on the single-event data to generate conformation event data; and reconstructing images from the conformation event data in the identified time intervals of each field to obtain reconstructed images corresponding to each field. Through intelligent identification of temporal distribution characteristics and a partitioned reconstruction strategy, the method of this application solves the problem of severe aliasing of PET signals in multi-field delivery modes, achieving accurate extraction and image reconstruction of the independent dose distribution of each field.

The present disclosure generally relates to the methods of treating solid tumors using negatively charged particles.

The present invention comprises: a high-frequency kicker (70) that generates an electric field having a component that kicks beams in the horizontal direction; and a magnetic pole that generates a peeler magnetic field region (44) that is a quadrupole magnetic field that is laterally asymmetric as viewed from the beam traveling direction in which the amplitude of the betatron oscillations is increased by the high-frequency kicker (70). The intensity of each frequency component of an electric field applied to the high-frequency kicker (70) is controlled from the relationship between the passage position of particles in the beams under the peeler magnetic field region (44) and the phase advance of the betatron oscillations per turn at the position of the high-frequency kicker (70).