83 results about "Healthy tissue" patented technology

Radiotherapy is the most widely used and effective anti-tumor therapy, however it can damage healthy tissues surrounding the tumor. One approach to reducing damage to healthy tissue involves irradiation at dose rates far exceeding those currently used in clinical contexts reduces radiation-induced toxicities while maintaining an equivalent tumor response. This is known as the FLASH effect. The mechanism responsible for reduced tissue toxicity following FLASH radiotherapy (FLASH-RT) is still undetermined; multiple hypotheses have been suggested by linking the high dose rate to rapid oxygen depletion, immune response, reduction of peroxyl radical lifetime, preservation of normal tissue stem cells, etc. While effective, proton therapy is underutilized, contributing to fewer than 2% of all external beam radiation treatments. To overcome this shortcoming, provided are methods which utilize the highest energy layer and a universal range shifter (URS) to facilitate rapid spot arc therapy (RAPIDSPARC™).

The invention discloses a self-adaptive control system based on a cutting anastomat, and relates to the technical field of medical instrument control, and the system comprises an intelligent hardware module which is used for analyzing a motion control instruction based on an MCU (Microprogrammed Control Unit), receiving a PWM (Pulse Width Modulation) signal by a DC motor driver, and starting a tool bit to advance according to a preset acceleration curve; the TACS module analyzes the tissue state based on sensor data and dynamically adjusts the rotating speed and cutting force of a motor; and the man-machine interaction visualization module is used for carrying out visual and clear graphical and digital presentation, including electric quantity, anastomosis pressure and cutting progress, on the basis of an electronic display screen. The MCU serves as the core, the tool bit is controlled to advance according to the preset curve through PWM signals, it is ensured that the cutting action is accurate and stable, the equipment loss and the tissue damage risk are reduced, the TACS module analyzes the tissue state in real time and dynamically adjusts the motor rotating speed and the cutting force through a sensor, the cutting effect can be ensured for tissue with different hardness and thickness, and the cutting efficiency is improved. Healthy tissues can be protected, and the operation safety and efficiency are improved.

The invention discloses a tumor radiotherapy non-irradiation area protection device, and relates to the cervical cancer radiotherapy protection field, and the tumor radiotherapy non-irradiation area protection device comprises a mounting frame, and the interior of the mounting frame is fixedly connected with a first telescopic driving member. The first moving mechanism and the second moving mechanism can respectively drive the moving frame and the adjusting plate to move back and forth and left and right, so that the through hole is accurately positioned to the radiotherapy position of the cervical cancer patient. The first rotation driving piece can drive the adjusting lead plate to rotate, so that the adjusting holes with proper sizes are aligned with cancer cells. The blocking adjusting mechanism further optimizes protection, and when a gap exists between the adjusting hole and the cancer cells, the driving mechanism drives the transmission ring to rotate, so that the second telescopic driving piece drives the pushing block to push the lead block plate to move, and the gap is filled. Thus, the first lead plate, the second lead plate and the adjusting lead plate act together to ensure that radiotherapy rays irradiate cancer cells only through the adjusting holes, so that the rays are effectively prevented from damaging surrounding healthy tissues, and adverse effects of radiotherapy on patients are reduced.

The invention discloses a radioactive medical isotope Ra-223 stably-labeled rare earth nano diagnosis and treatment preparation as well as a preparation method and application thereof. According to the invention, by constructing a dual protection mechanism of the shell layer and the functional biomolecular layer, the Ra-223 is effectively packaged, the recoil nuclei of the Ra-223 are reserved at the tumor part and are prevented from escaping to the surrounding environment of the tumor, the safety of the Ra-223 treatment process can be enhanced, the radioactive energy is ensured to accurately act on the focus, and the treatment effect of the Ra-223 is improved. Meanwhile, the damage risk to healthy tissues is minimized.

The scalpel comprises a first scalpel handle and a first scalpel head, the first scalpel head is detachably arranged at the front end of the first scalpel handle, a connecting insertion block is arranged at the front end of the first scalpel handle, and a step-shaped clamping groove is formed in the outward end of the connecting insertion block; the tail end of the first tool bit is provided with a connecting groove matched with the stepped clamping groove and the connecting inserting block in appearance, the front end of the first tool bit is provided with an integrally-formed extending part, the extending part is bent outwards, and the width of the end is gradually reduced to form a tip in the outward extending process of the extending part. Blades are arranged on the two side surfaces of the extension part; the extension part which is bent outwards can be suitable for narrow and irregular spaces around wisdom teeth, especially at different tooth position angles, and can be conveniently inserted into a gap between a gingiva and an alveolar bone, so that the connection between the gingiva and a dental crown neck as well as between the gingiva and an alveolar is completely cut and separated, and the end part of the extension part is a sharp end; and accurate puncture and combination of the starting point of the epithelium are facilitated, and damage to healthy tissues is reduced.

The invention relates to a high frequency magnetic induction device (100). The device (100) comprises magnetic nanosuspension (101) and an AMF generator (103). The AMF generator (103) further comprises copper induction coil (104), work head (105), flexible connector (106), power supply (107), chiller (108), display and control unit (109), fiberoptic thermometer sensors (110a &110b), auto-manual toggle switch (111), USB port (112a &112b) and bed support (113). Tumor site enclosed by the magnetic nanosuspension (101) comprising iron oxide magnetic nanoparticles (102) generates heat when exposed to AMF generated by the AMF generator (103). The heat generated does not cause any harm to the healthy tissues. The AMF generator (103) has precise control over thermal doses generated. The high frequency induction device (100) is safe, effective, non-invasive with mild side-effects.

The present application relates to the technical field of vascular interventional treatment instruments, and discloses a system and method for the selective laser ablation of restenosis after the treatment of Budd-Chiari syndrome, comprising a controller, a pulse emission module and a reference element built into a catheter, the system is based on the reference element for periodic self-calibration, collects and processes the associated photoacoustic signals to identify the tissue type, and then realizes the selective ablation of the diseased tissue and the boundary self-stop when the healthy tissue is touched. The present application converts the traditional open-loop energy delivery into a closed-loop self-control process with real-time information interaction capability, so that the ablation operation end can in-situ perceive the tissue boundary and realize autonomous stop, thereby avoiding the problem of damaging the healthy tissue due to uncontrollable energy application, improving the safety of the operation, and having the advantages of high precision, few complications, repeatable treatment and the like.

Various examples of the disclosure pertain to using whole-slide images that depict healthy tissue for a training process for at least one machine-learning algorithm for digital pathology. For instance, an autoencoder neural network can be trained based on the healthy tissue.

The invention relates to the technical field of vascular interventional therapy instruments, and discloses an excimer laser ablation system and method for restenosis after Budd-Chiari syndrome interventional therapy, the excimer laser ablation system comprises a controller, a pulse transmitting module and a reference element arranged in a catheter, and the system performs periodic self-calibration based on the reference element; according to the method, associated photoacoustic signals are collected and processed to identify tissue types, selective ablation of lesion tissues and boundary self-stop when healthy tissues are touched are further achieved, traditional open-loop energy delivery is converted into a closed-loop self-control process with real-time information interaction capacity, and the method has the advantages of being simple in structure, convenient to operate and high in practicability. The ablation operation tail end can sense the tissue boundary in situ and achieve automatic stopping, so that the problem that healthy tissue is damaged due to uncontrollable energy application is solved, the safety of an operation is improved, and the advantages of being high in precision, few in complication, capable of achieving repeated treatment and the like are achieved.

The invention relates to the technical field of focused ultrasound treatment, in particular to a real-time feedback phased array focused ultrasound treatment system, which comprises the following steps of: 1, fixing integrated equipment of ultrasonic transducers and EIT electrodes which are alternately and annularly arranged on a head, acquiring a three-dimensional image of the head by using imaging technologies such as CT or MRI and the like, and marking the spatial positions of the electrode, the ultrasonic array and the treatment target spot on the image. According to the invention, brain region real-time three-dimensional electrical impedance imaging is used as feedback, the excitation time sequence, intensity and phase of the ultrasonic array are adaptively adjusted, the influence of skull structure difference on ultrasonic focusing can be effectively overcome, the system calculates the phase shift of the ultrasonic array in real time, it is ensured that an ultrasonic beam is accurately focused at a treatment target, and the treatment accuracy is improved. The device is particularly suitable for a patient with a complex skull structure, the treatment accuracy is improved, it is ensured that ultrasonic energy accurately acts on a lesion area, and damage to surrounding healthy tissue is avoided.

This invention discloses an adjustable pressure constant temperature wound irrigation device, belonging to the field of wound irrigation technology. It includes a constant temperature water tank, with a first connecting pipe fixedly connected to the output end of the water tank. A water pump is installed at one end of the first connecting pipe, and a second connecting pipe fixedly connected to the output end of the water pump. A fixed support is fixedly connected to the bottom of the second connecting pipe. A wound adaptor is also included, with the pressure adaptor disposed inside the fixed support for adapting to wounds of different lengths and adjusting the extension length of the water outlet. This invention, by incorporating a wound adaptor and precisely controlling the extension distance of the spray nozzle to match the wound length through motor start / stop, ensures that the irrigation water flow targets and covers the entire wound area, guaranteeing comprehensive and effective irrigation while avoiding irritation of surrounding healthy tissue. It also replaces manual adjustment, improving the accuracy, controllability, and standardization of operation, while reducing patient discomfort and balancing the effectiveness and comfort of the treatment procedure.

The invention discloses a soluble microneedle patch for skin tumors and a preparation method and application thereof, and belongs to the technical field of soluble microneedles, gel formed by a microneedle matrix which is excellent in biocompatibility and contains disulfide bonds is injected into a microneedle mold, and the soluble microneedle patch is prepared. Then vacuumizing, centrifuging, adding viscous microneedle substrate polyacrylic acid gel, and drying to obtain the specific soluble microneedle patch of which the dissolution rate in a tumor microenvironment is obviously higher than that of normal tissues. The microneedle matrix with disulfide bonds specifically responds to the high reducibility of a tumor microenvironment, the drug is rapidly broken and released, the drug release amount in a normal skin area is reduced, stimulation to healthy tissue is avoided, potential damage to normal tissue is reduced, and more accurate targeted therapy is achieved.

This application relates to the field of medical devices and discloses a wound cleaning device for orthopedic care. The device includes a cleaning bed; a drainage pipe disposed at the bottom of the cleaning bed; a pump assembly and a reciprocating sliding assembly disposed on the cleaning bed; an arc-shaped cleaning disc disposed within the reciprocating sliding assembly and communicating with the pump assembly; detection components disposed on both sides of the arc-shaped cleaning disc; a drive assembly, a positioning assembly, and a dispensing assembly disposed within the arc-shaped cleaning disc, with the drive assembly connected to the positioning assembly; the dispensing assembly contains multiple arc-shaped baffles, a lifting assembly, and a pulse cleaning assembly; and a conversion assembly disposed within the drive assembly. This cleaning device allows for convenient activation of the corresponding drive assembly to form a medication path based on the wound area, preventing medication from spraying onto surrounding healthy tissue, reducing medication waste, and minimizing patient discomfort.

A method includes receiving one or more radiological images of an anatomy of a patient. The method also includes identifying a boundary of different tissue types in the anatomy of the patient based at least partially upon the one or more radiological images. The method also includes identifying one or more regions within the boundary. The one or more regions include a lung region. The method also includes identifying healthy tissue and COVID-19 tissue in the lung region. The method also includes quantifying an extent of the COVID-19 tissue in the lung region by comparing an amount of the COVID-19 tissue in the lung region to an amount of the healthy tissue in the lung region. The method also includes classifying the extent of the COVID-19 tissue in the lung region into one or more of a plurality of COVID-19 classes.

The invention relates to the technical field of medical image processing and tumor treatment planning, and discloses a tumor ablation assessment method based on clustering and dynamic weight Monte Carlo sampling, and the method comprises the steps: dividing a tumor, i.e., a healthy region, through spatial clustering, optimizing sample distribution in combination with an error feedback mechanism related to a region density compensation factor, and obtaining a tumor ablation result; introducing a momentum enhanced weight updating strategy, correcting sparse region sampling deviation, adaptively balancing historical errors, rapidly judging a sample membership relationship through an ablation ellipsoid model, and synchronously calculating a tumor ablation coverage rate and a healthy tissue damage rate; the tumor ablation coverage rate and the healthy tissue damage rate can be rapidly, stably and accurately calculated synchronously, and a reliable quantitative basis is provided for real-time planning in an operation and accurate evaluation after the operation.

New compositions and methods are described herein operable for delivery of therapeutic agents while mitigating damage to healthy tissues. In one aspect, a conjugate comprises a linker joining a pharmaceutical component and a targeting ligand, wherein the linker is at least one of radiolabile, photolabile, thermolabile, chemically labile, magnetically labile, or acoustolabile for release of the targeting ligand and / or the pharmaceutical component from the conjugate.

The invention provides an energy type robot treatment system and method for AI driving, the system comprises a robot arm, a multi-mode sensor kit and an AI control unit, and an end effector capable of generating treatment energy is installed at the tail end of the robot arm. A trained machine learning model on an AI control unit is used for processing real-time data collected by a multi-mode sensor suite from a treatment part, and the machine learning model is combined with pre-loaded patient data to generate a predictive control signal; the AI-driven control can achieve accurate and selective ablation of cancer tissue while minimizing incidental damage to surrounding healthy tissue, so as to improve the therapeutic effect, by dynamically adjusting the therapeutic parameters and height position parameters of the end effector.

The application relates to the technical field of medical systems, in particular to an AI-assisted precise ablation operation robot, and the technical scheme acquires tissue information on a track, fluctuation characteristics of organs and path track information through a data acquisition terminal, analyzes ablation risks and tissue risks caused by the fluctuation characteristics of the organs on the path track and the tolerance characteristics of the tissue information, and evaluates the track risks by comprehensively analyzing the ablation risks and the tissue risks, so that the ablation path is optimized through multi-modal data fusion and dynamic risk evaluation, the damage risk to surrounding healthy tissues is reduced while ensuring sufficient coverage of a lesion, and the core innovation lies in layered quantification of ablation risks and tissue risks caused by organ fluctuation, so that safer and more precise ablation treatment is realized.

The present invention relates to a non-invasive magneto-acoustic apparatus for healthy tissue healing and cancer regression comprising at least one pulsed ultrasound unit (LIPUS), at least one permanent magnet, at least one module housing, at least one permanent magnets, at least one control system for controlling pulsed ultrasound unit to energize the unit with desired pulse duration, intensity and active / ON time. The invention is to synchronously use the low intensity pulsed ultrasound (LIPUS) and static magnetic field (SMF) to selectively activate cellular activities specific to cartilage, bone, skin leading to accelerated tissue healing, regeneration. The invention apparatus is to inhibit cancer cellular activities specific to cancers of breast, skin, bone leading to enhanced cancer regression, while leaving the healthy cells unaffected using magneto-acoustic apparatus appropriately. The apparatus exhibit no toxicity to healthy cells and can reduce overall treatment time and costs due to accelerated tissue repair and tumor regression.

The application discloses a kind of health multi-phase image guided multi-phase lesion image segmentation methods, this method mainly includes: using healthy multi-phase contrast-enhanced CT training deep learning network, freeze its parameters, then send lesion CT image into trained healthy image network and another network structure consistent with the lesion image network to be trained.Healthy image network acts as normal tissue feature extractor, assist lesion image network training;Wherein, the loss function of healthy image network adopts the combination of Dice loss function and cross-entropy loss function, the loss function of lesion image network includes the mean square error loss function of feature map extracted by healthy image network and lesion image network to lesion image in addition to above-mentioned two loss functions.The application scheme distinguishes healthy tissue and lesion tissue by guiding lesion image network with healthy image, and the segmentation precision of lesion tissue is improved.

The invention relates to the technical field of medical systems, in particular to an AI-assisted precise ablation surgical robot, and adopts the technical scheme that tissue information on a trajectory, fluctuation characteristics of organs and path trajectory information are acquired through a data acquisition terminal; ablation risks and tissue risks caused by fluctuation characteristics of visceral organs on a path trajectory and tolerance characteristics of tissue information are analyzed, and meanwhile, trajectory risks are evaluated by integrating analysis results of the ablation risks and the tissue risks, so that the method has the advantages that an ablation path is optimized through multi-modal data fusion and dynamic risk evaluation, and the risk assessment efficiency is improved. The risk of injury to surrounding healthy tissues is reduced while full coverage of a focus is ensured, and the core innovation of the system is to quantify ablation danger and tissue danger caused by organ fluctuation in a layered manner, so that safer and more accurate ablation treatment is realized.

The utility model provides a multifunctional sawtooth-shaped ultrasonic debridement working rod. The multifunctional sawtooth-shaped ultrasonic debridement working rod comprises a connecting rod and an ultrasonic transducer. The head part of the connecting rod is provided with a tool bit for cutting tissues, and the tool bit is provided with a blade formed by a plurality of sawteeth; and the ultrasonic transducer is connected with the connecting rod, and can drive the connecting rod to generate ultrasonic vibration during working. The tool bit is provided with a blade formed by a plurality of sawteeth; the saw teeth can enhance the cutting effect on necrotic tissues, and meanwhile excessive damage to healthy tissues is avoided. Meanwhile, the working rod is connected with the ultrasonic transducer, and the ultrasonic transducer can drive the connecting rod to generate ultrasonic vibration when working, so that the tool bit generates ultrasonic vibration to adapt to necrotic tissues of different hardness and types, the cutting effect is further improved, and the application range is further widened.

The dilatation balloon device comprises a catheter, a first balloon body, a protruding structure and a connecting piece, the catheter extends in the front-back direction, a first channel penetrating in the front-back direction is formed in the catheter, the first balloon body is arranged at the front end of the catheter, the front end of the first channel is communicated with the interior of the first balloon body, and the rear end of the first channel is communicated with a pressurizing device. The protruding structures are arranged on the outer surface of the first bag body in a protruding mode and distributed in a long shape extending in the front-back direction, in a projection view perpendicular to the front-back direction, the protruding structures are distributed on the periphery of the first bag body in a non-centrosymmetric mode, and the connecting piece is arranged at the rear end of the catheter and used for communicating the first channel with the pressurizing device. In the invention, the bulge structure can apply pressure to the affected part in a targeted manner, so that the affected part is cracked before other tissues in the bulge process of the first capsule body, and the treatment purpose is achieved. Therefore, the treatment accuracy can be improved, unnecessary tearing of healthy tissues is reduced, the complication risk is reduced, and the minimally invasive treatment requirements of diseases such as benign prostatic hyperplasia are met.

The present application relates to the technical field of medical devices, and provides a continuum mechanical arm structure integrated with laser focusing and ultrasonic feedback functions, comprising a distal continuum module, a proximal continuum module, a first driving tendon and a second driving tendon, the first driving tendon being used for controlling movement of the distal continuum module, and the second driving tendon being used for controlling movement of the proximal continuum module; a pose detection module and a laser optical module are sequentially arranged at the front end of the distal continuum module, the pose detection module is used for acquiring relative pose information of a target lesion, and the laser optical module is used for projecting laser energy to treat the target lesion; an endoscope vision module is arranged on the side wall of the distal continuum module, and the endoscope vision module is used for acquiring image information. The present application not only can improve the flexibility and adaptability of surgery, but also can realize precise treatment, improve treatment effect, avoid damage to surrounding healthy tissues, reduce surgical risk, and meet the requirements of flexibility and accuracy of orthopedic treatment.

The utility model relates to the technical field of medical instruments, in particular to biopsy forceps special for orthopedic surgery robot positioning, which comprise positioning forceps, a positioning plate is mounted on one side of the positioning forceps, a threaded hole is formed in the middle of the positioning plate, a rotating shaft is in threaded connection with the inside of the threaded hole, a sliding column is slidably arranged in the rotating shaft, and the sliding column is connected with the positioning plate. A fixing box is fixedly connected to the bottom end of the rotating shaft, the end, away from the positioning plate, of the sliding column is located in the fixing box, a pair of cutting plates used for cutting pathological tissue is arranged on the side, away from the positioning plate, of the fixing box, and sliding assemblies used for driving the pair of cutting plates to move are arranged at the end, away from the positioning plate, of the sliding column and in the fixing box. The utility model provides a pair of biopsy forceps special for positioning of an orthopedic surgery robot, and aims to solve the problems that when the conventional biopsy forceps are used, healthy tissues are possibly injured by clamping and pulling of a cutting plate, and the tissues cannot be well taken out and the sampling efficiency is influenced because the pedicles of the clamped tissues cannot be cut off in time.

This invention discloses an automated oral medication applicator, relating to the field of oral medication technology. It includes a shell, an internal medication storage box, a connecting cylinder connected to one side of the storage box, a flexible tube threaded onto the inner surface of the connecting cylinder, and a pipe connected to the output end of the flexible tube. An internal conveying component is also included, with its input end connected to the pipe and its output end connected to an output pipe. A conduit is threaded onto the output end of the output pipe. This automated oral medication applicator utilizes a visual system comprised of a miniature camera, a supplemental light, and a display screen to avoid limited visibility within the oral cavity. Even hidden lesions such as those in the throat or behind wisdom teeth can be clearly seen. Users can perform precise positioning under visual guidance. Combined with a flexible and shapeable conduit, this ensures the applicator head accurately reaches the lesion, effectively preventing medication from being applied to healthy tissue due to hand tremors or poor visibility, thereby improving the targeting and effectiveness of drug treatment.

The invention discloses a system for treating oral diseases through a pulsed electric field, according to at least one preset energy output algorithm, at least one target energy packet corresponding to the preset energy output algorithm is generated, and different types of oral lesion tissues can be more flexibly, accurately and selectively treated through the target energy packet; moreover, when the energy of the target energy packet is utilized to ablate pathological cells, extracellular matrixes are not damaged, and protein denaturation is not generated, so that obvious scars or tissue ablation traces are not caused to tissues; at the same time, treatment by non-thermal methods can maintain the collagen structure in the oral cavity, allowing the regeneration of healthy oral mucosa with normative healthy tissues.

The present application relates to the technical field of rectal cancer CTV segmentation, in particular to a rectal cancer CTV segmentation method based on CViL-UNet, comprising the following steps: preprocessing rectal cancer CT image data, converting a 3D CT sequence into a multi-channel 2D input format, removing image noise and intensity non-uniformity, and standardizing the pixel value range to adapt to the CViL-UNet model input. The present application realizes accurate identification of the key areas of CTV primary tumor, subclinical spread area and micro-infiltration focus through local-global feature cooperation and high-frequency detail enhancement, solves the pain points of missing micro-infiltration and misjudging healthy tissue in traditional methods, can process conventional CT images without intestinal preparation, breaks the dependence of traditional methods on ideal image conditions, and the automatic and real-time segmentation process in clinical value eliminates the subjectivity and inefficiency caused by manual intervention, while meeting the dual requirements of millimeter-level precision and rapid deployment for radiotherapy planning.

This invention relates to a method for simulating the distribution of magnetofluid injection based on the coupling of particle tracking and fluid dynamics, belonging to the field of magnetic nanoparticle movement and particle tracking. The method includes: constructing a two-dimensional geometric model containing healthy tissue, abnormal tissue, and an injection syringe, and setting parameters; constructing a fluid model based on Darcy's law, and calculating the fluid velocity and pressure distribution in the interstitial tissue; coupling the fluid velocity, and solving the diffusion-convection-reaction equation using the finite element method to obtain the macroscopic concentration distribution of the magnetofluid after injection; establishing a particle tracking module, setting discrete particles with the same properties as the magnetic nanoparticles; coupling the interstitial fluid velocity, calculating the drag force and gravity acting on the particles according to Newton's second law, and simulating the particle motion to reveal the microscopic trajectory of the magnetic nanoparticles. This method, by coupling the macroscopic concentration field with the microscopic particle motion, can more realistically simulate the distribution behavior of magnetofluid within complex porous biological tissues.

A method for treating a tumor in a subject is provided, the method comprising introducing nanoparticles into the tumor, generating alternating RF magnetic fields microwave electromagnetic waves; measuring temperatures of the tumor and of healthy tissue in close proximity to the tumor; and adjusting one or more properties of the RF magnetic fields and / or microwave electromagnetic waves based on the measured temperatures, such that the combination of the RF magnetic fields and the microwave electromagnetic waves cooperate to heat the tumor region to an ablative temperature without substantially heating the healthy tissue which is in close proximity to the tumor.