156 results about "Healthy tissue" patented technology

The invention discloses a medical image fuzzy boundary segmentation method based on an edge perception Mama network. The method aims at solving the problems that a camouflage pathological structure in a medical image is visually similar to surrounding healthy tissues, so that segmentation is difficult, and clinical deployment is difficult due to secondary calculation complexity of an attention mechanism in a traditional camouflage target detection (COD) method. According to the invention, a boundary guiding module inspired by COD is creatively combined with linear complexity state space modeling, and an E-Mama edge guiding framework is provided. The framework adopts an encoder-edge guide-decoder structure, and accurate boundary description is realized while the computational efficiency is kept. The system comprises five core components: a Mama encoder; an adaptive fusion processing module (AFM); an edge detection module (EDM); an edge guidance module (EGM); the invention relates to a Mama decoder. Experiments show that advanced segmentation precision is realized on a plurality of medical data sets, and meanwhile, the calculation complexity is reduced from O (n2) to O (n), so that clinical deployment becomes possible.

According to the precise diagnosis and treatment integrated platform and method based on the coupling model, the cavitation effect is predicted through numerical simulation, negative feedback adjustment is conducted on microbubble mediated ultrasonic treatment, and precise control over the microbubble mediated ultrasonic treatment is achieved. Acoustic parameters are adjusted in real time, it can be ensured that treatment focuses on a lesion area, damage to surrounding healthy tissue is reduced, and therefore the accuracy and safety of treatment are improved. The platform integrates cavitation detection and an acoustic feedback mechanism, the microbubble cavitation effect can be monitored in real time, and treatment parameters can be automatically adjusted. Negative feedback closed-loop control can ensure a stable cavitation state, tissue damage caused by excessive cavitation is effectively avoided, and the stability and reliability of treatment are improved. The platform simplifies the operation process of controlling acoustic parameters. A doctor can complete the whole process from treatment to monitoring on the same operation interface through the integrated platform, and convenience and efficiency of clinical operation are improved. The platform is not only suitable for tumor treatment, ablation and drug delivery, but also can be applied to multiple treatment fields such as vascular diseases and neuromodulation, and has wide clinical application prospects and market potential.

The invention relates to the technical field of medical care, and particularly discloses an oral cancer perioperative nursing decision method, which comprises the steps of image acquisition, model generation, preoperative evaluation, dynamic nursing, risk evaluation and decision support. According to the scheme, the tumor area is extracted from the three-dimensional image data based on the U-Net model, the tumor area is separated from surrounding healthy tissue, complex tumor forms are automatically processed, higher segmentation precision and robustness are provided, and finally the accurate three-dimensional anatomical model is generated; according to the scheme, the individualized data, the real-time physiological indexes and the treatment progress of the patient are obtained, the intelligent optimization algorithm is used for calculating the priority of each nursing measure, the individualized nursing decision is dynamically generated according to the priority, the most suitable nursing scheme is automatically provided for the patient, and individualized requirements of different patients are better met.

Radiotherapy is the most widely used and effective anti-tumor therapy, however it can damage healthy tissues surrounding the tumor. One approach to reducing damage to healthy tissue involves irradiation at dose rates far exceeding those currently used in clinical contexts reduces radiation-induced toxicities while maintaining an equivalent tumor response. This is known as the FLASH effect. The mechanism responsible for reduced tissue toxicity following FLASH radiotherapy (FLASH-RT) is still undetermined; multiple hypotheses have been suggested by linking the high dose rate to rapid oxygen depletion, immune response, reduction of peroxyl radical lifetime, preservation of normal tissue stem cells, etc. While effective, proton therapy is underutilized, contributing to fewer than 2% of all external beam radiation treatments. To overcome this shortcoming, provided are methods which utilize the highest energy layer and a universal range shifter (URS) to facilitate rapid spot arc therapy (RAPIDSPARC™).

The invention discloses a special-shaped probe multi-point refrigerating system for bronchoscope cryopreservation, and relates to the technical field of medical instruments, the special-shaped probe multi-point refrigerating system mainly comprises a probe, an air pressure sensing execution sleeve and a wireless computer control system, the special-shaped probe on the probe is provided with four dome cylindrical protruding parts, the middle of the special-shaped probe is sunken, and five capillary tubes are arranged in the probe; the five point refrigeration areas correspond to the convex part and the concave part of the special-shaped probe respectively, so that the five point refrigeration areas are independent; an initial pressure value required by pressure reduction and heat absorption of high-pressure gas is calculated, a wireless signal is transmitted by a computer control system, and then the five air pressure sensing execution sleeves release corresponding pressure, so that the temperature of different point positions on the special-shaped probe is different. Meanwhile, the provided multi-point refrigeration system achieves independent adjustment of the temperatures of different point positions in the probe, prevents the probe from touching and frostbite surrounding healthy tissues by mistake, and has a good clinical application prospect.

The invention discloses a magnetic resonance guided focusing microwave brain tumor thermal ablation system and a focusing adjustment method. According to the invention, three-dimensional data of MRI and CT are integrated, microwave frequency suitable for tumor size and depth is selected, and an appropriate antenna and cross polarized antenna phased array is designed. The output power and phase of the antenna are optimized by using a differential evolution algorithm, accurate focusing of microwave energy is realized, the tumor temperature is increased to an ablation level, and meanwhile, the safe temperature of healthy tissues is kept. The system effectively inhibits adverse effects of brain tissues including skull on microwave penetration, and realizes accurate ablation of tumors through combination of a small number of antennas and an iterative algorithm. MRI guidance and real-time temperature monitoring are combined, so that the accuracy and safety of thermal ablation are ensured, the brain tumor is radically treated in a non-invasive manner, and the problem that the medicine cannot penetrate through the blood brain barrier is solved. In addition, the technology can also be used for treating liver cancer, pancreatic cancer, thyroid cancer, breast cancer, kidney cancer, bone cancer, bladder cancer, gallbladder cancer and other diseases.

The invention discloses a radiotherapy device for a radiotherapy department, which belongs to the technical field of radiotherapy and comprises a fixing cover, a fixing frame is fixedly mounted in the fixing cover, a plurality of scanners for scanning a human body are mounted on the lower side of the fixing frame, and an imaging module for image-guided radiotherapy is further fixedly mounted on the fixing frame. A data processing module is fixedly installed on the portion, located on one side of the imaging module, of the fixing frame, the imaging module transmits image information to the data processing module, the image information is recorded through the data processing module, and the data processing module is further connected with a chest movement sensor. The breathing rhythm of a patient can be monitored through the chest movement sensor, the change of a tumor can be observed through cooperation with the scanner and the imaging module, the position of the tumor is determined through the data processing module, radiation can be accurately radiated to a designated position during follow-up tumor treatment, and the treatment efficiency is improved. And damage to surrounding healthy tissues caused by radiation position deviation due to deviation is avoided.

The invention discloses a self-adaptive control system based on a cutting anastomat, and relates to the technical field of medical instrument control, and the system comprises an intelligent hardware module which is used for analyzing a motion control instruction based on an MCU (Microprogrammed Control Unit), receiving a PWM (Pulse Width Modulation) signal by a DC motor driver, and starting a tool bit to advance according to a preset acceleration curve; the TACS module analyzes the tissue state based on sensor data and dynamically adjusts the rotating speed and cutting force of a motor; and the man-machine interaction visualization module is used for carrying out visual and clear graphical and digital presentation, including electric quantity, anastomosis pressure and cutting progress, on the basis of an electronic display screen. The MCU serves as the core, the tool bit is controlled to advance according to the preset curve through PWM signals, it is ensured that the cutting action is accurate and stable, the equipment loss and the tissue damage risk are reduced, the TACS module analyzes the tissue state in real time and dynamically adjusts the motor rotating speed and the cutting force through a sensor, the cutting effect can be ensured for tissue with different hardness and thickness, and the cutting efficiency is improved. Healthy tissues can be protected, and the operation safety and efficiency are improved.

The invention discloses a tumor radiotherapy non-irradiation area protection device, and relates to the cervical cancer radiotherapy protection field, and the tumor radiotherapy non-irradiation area protection device comprises a mounting frame, and the interior of the mounting frame is fixedly connected with a first telescopic driving member. The first moving mechanism and the second moving mechanism can respectively drive the moving frame and the adjusting plate to move back and forth and left and right, so that the through hole is accurately positioned to the radiotherapy position of the cervical cancer patient. The first rotation driving piece can drive the adjusting lead plate to rotate, so that the adjusting holes with proper sizes are aligned with cancer cells. The blocking adjusting mechanism further optimizes protection, and when a gap exists between the adjusting hole and the cancer cells, the driving mechanism drives the transmission ring to rotate, so that the second telescopic driving piece drives the pushing block to push the lead block plate to move, and the gap is filled. Thus, the first lead plate, the second lead plate and the adjusting lead plate act together to ensure that radiotherapy rays irradiate cancer cells only through the adjusting holes, so that the rays are effectively prevented from damaging surrounding healthy tissues, and adverse effects of radiotherapy on patients are reduced.

The invention discloses a hyperspectral imaging-based rice blast early diagnosis method, and relates to the technical field of agricultural disease monitoring, and the specific steps of the method are as follows: S100, obtaining spectral data of rice in a region, S200, constructing a healthy tissue end member spectrum and predicting a lesion tissue end member spectrum, S300, constructing a mixed pixel model, and combining constraint conditions to determine the early diagnosis of rice blast. According to the method, through the mixed pixel model of the time sequence dynamic end members, the fine change of the spectrum can be accurately captured in the early stage of rice blast infection, through continuous time sequence hyperspectral imaging, the real-time spectrum of the rice blast can be accurately captured, and the real-time spectrum of the rice blast can be obtained. And learning dynamic evolution of a lesion end member spectrum by combining an LSTM network, regarding a mixed pixel at each time point as a mixture of a healthy tissue end member spectrum and a gradually evolved lesion tissue end member spectrum, and inverting the state and abundance of the lesion tissue end member spectrum at each time point so as to quantitatively monitor the early development progress of infection.

The invention belongs to the technical field of automatic control, and discloses an intelligent tracking type ray inspection area self-adaptive shielding control system and method. Comprising the steps of collecting a human body three-dimensional image in real time; recognizing and extracting a human body contour region from the human body three-dimensional image; carrying out fine segmentation on the human body contour region to obtain a tissue regions; performing intelligent analysis on each tissue area, and determining an occlusion area in the tissue area; obtaining area space information of each shielding area, and coordinating and controlling each protection component to shield the corresponding shielding area; detecting the movement track of the human body in the examination process in real time, and generating corresponding movement change data for each shielding area; according to the movement change data, the protection assembly corresponding to each shielding area is dynamically controlled; the radiation influence of rays on healthy tissues can be effectively reduced, and the protection safety and the examination efficiency in the ray examination process are improved.

The invention discloses a radioactive medical isotope Ra-223 stably-labeled rare earth nano diagnosis and treatment preparation as well as a preparation method and application thereof. According to the invention, by constructing a dual protection mechanism of the shell layer and the functional biomolecular layer, the Ra-223 is effectively packaged, the recoil nuclei of the Ra-223 are reserved at the tumor part and are prevented from escaping to the surrounding environment of the tumor, the safety of the Ra-223 treatment process can be enhanced, the radioactive energy is ensured to accurately act on the focus, and the treatment effect of the Ra-223 is improved. Meanwhile, the damage risk to healthy tissues is minimized.

The full-automatic meniscus cutter comprises a plasma cutter head, a connecting rod, a rotating shaft, a joint insertion rod, a supporting frame and a control system, the plasma cutter head is connected to the front end of the connecting rod and used for cutting lesion tissue of a meniscus, and the rear end of the connecting rod is connected with the rotating shaft; the rotating shaft is rotationally connected to the rear end of the joint insertion rod and is perpendicular to the joint insertion rod, the front end of the joint insertion rod is used for being inserted into a joint cavity and abutting against a joint capsule, a rotating driver used for driving the rotating shaft to rotate is arranged on the supporting frame, and the connecting rod is of a telescopic rod structure and is provided with a telescopic driver used for driving the connecting rod to stretch out and draw back. The control system is electrically connected with the rotating driver and the telescopic driver and used for commanding and controlling the rotating shaft to rotate and commanding and controlling the plasma tool bit to reciprocate front and back. The meniscus cutter has the advantages that automatic cutting and precise cutting are achieved, operation time is shortened, damage to surrounding healthy tissue is reduced, and monitoring and precise control are achieved.

The present technology can be used to selectively heat one or more diseased regions in the lung while limiting heating of healthy regions and surrounding tissue. This heating provides a therapeutic effect. Selective heating of diseased tissue can be achieved by exposing the lung to an electromagnetic field to cause dielectric or eddy current heating. The present technology is particularly useful for treating emphysema because the diseased regions of emphysema patients have reduced blood flow. The diseased regions will heat up quickly while healthy tissue will be cooled by blood flow. This is particularly effective for treating emphysema because the lung has a small mass and high blood flow. In one described embodiment, the frequency of the electromagnetic radiation is chosen to satisfy certain resonance conditions of the device. In another described embodiment, a coil is used to apply the electromagnetic radiation, the geometric parameters of the coil being chosen so that an electric field maximum is produced in the region to be heated. In another described embodiment, a pair of electromagnetic energy signal applicators are used to apply the electromagnetic radiation, the pair of electromagnetic energy signal applicators being positioned to surround the torso of the patient, one electromagnetic energy signal applicator being positioned cephalad relative to the treatment region and the other electromagnetic energy signal applicator being positioned caudal relative to the treatment region, and the pair of electromagnetic energy signal applicators being shaped to encircle or partially encircle the periphery of the torso.

The utility model belongs to the technical field of medical electroporation treatment, and provides an ablation catheter for adjusting an ablation position, which mainly comprises a pushing sheathing canal, a first cavity channel, a second cavity channel, a first electrode and a second electrode, the ablation electrode is provided with a first end and a second end, and the ablation electrode divides the pushing sheathing canal into a far part and a near part which are relatively independent; the first end of the ablation electrode is connected with the near part of the pushing sheathing canal, and the second end of the ablation electrode is connected with the far part of the pushing sheathing canal; the insulating sleeve is arranged on the outer side of the pushing sheathing canal in a sleeving mode, one end of the insulating sleeve is arranged close to the first end or the second end of the ablation electrode, the insulating sleeve and the pushing sheathing canal can move relatively, and the moving direction is consistent with the axis direction of the pushing sheathing canal; the relative movement occurs between the pushing sheath tube and the insulating sleeve, so that the insulating sleeve wraps the ablation electrode in an insulating manner, and the effective ablation length of the exposure of the ablation electrode is controlled. By controlling the effective ablation length of the ablation electrode, accurate control over the ablation area is achieved, influences on surrounding healthy tissue are avoided, operation is convenient, and practicability is high.

The scalpel comprises a first scalpel handle and a first scalpel head, the first scalpel head is detachably arranged at the front end of the first scalpel handle, a connecting insertion block is arranged at the front end of the first scalpel handle, and a step-shaped clamping groove is formed in the outward end of the connecting insertion block; the tail end of the first tool bit is provided with a connecting groove matched with the stepped clamping groove and the connecting inserting block in appearance, the front end of the first tool bit is provided with an integrally-formed extending part, the extending part is bent outwards, and the width of the end is gradually reduced to form a tip in the outward extending process of the extending part. Blades are arranged on the two side surfaces of the extension part; the extension part which is bent outwards can be suitable for narrow and irregular spaces around wisdom teeth, especially at different tooth position angles, and can be conveniently inserted into a gap between a gingiva and an alveolar bone, so that the connection between the gingiva and a dental crown neck as well as between the gingiva and an alveolar is completely cut and separated, and the end part of the extension part is a sharp end; and accurate puncture and combination of the starting point of the epithelium are facilitated, and damage to healthy tissues is reduced.

The invention relates to a high frequency magnetic induction device (100). The device (100) comprises magnetic nanosuspension (101) and an AMF generator (103). The AMF generator (103) further comprises copper induction coil (104), work head (105), flexible connector (106), power supply (107), chiller (108), display and control unit (109), fiberoptic thermometer sensors (110a &110b), auto-manual toggle switch (111), USB port (112a &112b) and bed support (113). Tumor site enclosed by the magnetic nanosuspension (101) comprising iron oxide magnetic nanoparticles (102) generates heat when exposed to AMF generated by the AMF generator (103). The heat generated does not cause any harm to the healthy tissues. The AMF generator (103) has precise control over thermal doses generated. The high frequency induction device (100) is safe, effective, non-invasive with mild side-effects.

The present application relates to the technical field of vascular interventional treatment instruments, and discloses a system and method for the selective laser ablation of restenosis after the treatment of Budd-Chiari syndrome, comprising a controller, a pulse emission module and a reference element built into a catheter, the system is based on the reference element for periodic self-calibration, collects and processes the associated photoacoustic signals to identify the tissue type, and then realizes the selective ablation of the diseased tissue and the boundary self-stop when the healthy tissue is touched. The present application converts the traditional open-loop energy delivery into a closed-loop self-control process with real-time information interaction capability, so that the ablation operation end can in-situ perceive the tissue boundary and realize autonomous stop, thereby avoiding the problem of damaging the healthy tissue due to uncontrollable energy application, improving the safety of the operation, and having the advantages of high precision, few complications, repeatable treatment and the like.

One or more new indicators are introduced in the process of processing the plan. More specifically, correction factors / metrics referred to herein as key / repair ratio indices are introduced, and / or spatially periodic correction factors / metrics referred to herein as key equal dose values are introduced. By using these indicators, the expected savings of the dose spatial distribution may be better considered in the processing mode, including general spatially segmented radiation therapy (SFRT) and particularly SFRT with ultra-high dose rates. The targets may be covered by extended Bragg peaks according to a treatment plan strategy to optimize and / or homogenize target levels of dose distribution, but still can benefit from SFRT saving effects at healthy tissue levels. Transport techniques include a dynamic focusing technique and a magnetic bundle steering technique. Increasing the dose rate can maximize the peak valley dose distribution of SFRT despite movement of the patient.

Systems and methods of predicting microcalcification activity in a vascular vessel comprising either an artery or a vein, comprising the steps of: (a) measuring patient data comprising one or more of: the existence of and / or quantity of coronary plaques or visible markers of disease in a vascular tissue sample; the existence of and / or quantity of healthy tissue in the vascular tissue sample; one or more features that define an abnormal hemodynamic environment in a vessel; one or more geometric features that are associated with vascular remodeling and which influence hemodynamics in a vessel, and / or one or more material properties that influence vascular hemodynamics; and (b) calculating the microcalcification activity in the vessel as a function of the measurements taken in Step (a).

Various examples of the disclosure pertain to using whole-slide images that depict healthy tissue for a training process for at least one machine-learning algorithm for digital pathology. For instance, an autoencoder neural network can be trained based on the healthy tissue.

Broadly speaking, the present techniques generally relate to a method for processing images of an organ (or part thereof) using a trained machine learning, ML, model in order to more efficiently and accurately provide information on different tissue regions of the organ. Advantageously, the ML model generates an augmented image of the organ showing the different tissue regions, such as diseased tissue regions and healthy tissue regions. This may help a surgeon to decide where to perform a surgical intervention in a way that only diseased tissue is excised.

The present invention relates to the technical field of medical surgical instruments, and specifically relates to a shield surgical robot, which includes a sheath. An annular placement groove is formed on the sheath. An optical fiber endoscope tube is arranged inside the annular placement groove. A placement plate is arranged on one side of the sheath. A protective cleaning component is arranged on the side of the optical fiber endoscope tube close to the placement plate. A water storage chamber is arranged inside the annular placement groove. Jet mechanisms are arranged in an array on the side of the water storage chamber close to the protective cleaning component. A shield electrocautery rotary cutter head is movably arranged on the side of the placement plate far from the inside of the sheath. The present invention has the function of timely cleaning the broken tissues that block the view of the optical fiber endoscope tube. At the same time, during the entire cleaning process, it will not affect the medical staff's real-time observation of the patient's body, and avoids the situation that the medical staff damages healthy tissues when cutting hyperplastic tissues under poor vision conditions.

This invention discloses a multifunctional tumor-targeted cryotherapy nanoplatform and its applications, belonging to the field of nanobiomedicine technology. The multifunctional tumor-targeted cryotherapy nanoplatform of this invention uses two-dimensional Ti3C2 nanomaterials as a carrier, loaded with indocyanine green as a photosensitizer, surface-modified with polydopamine to improve stability, and loaded with gambogeylic acid as an anti-tumor drug and a heat shock protein inhibitor. It is covalently coupled with nucleic acid aptamers that can recognize cell surface-specific proteins. The multifunctional tumor-targeted cryotherapy nanoplatform has small particle size, high dispersion, and good biocompatibility, and exhibits excellent photothermal conversion ability, photodynamic therapy effect, and chemotherapy effect in tumor-targeted therapy. It can effectively induce tumor cell apoptosis under relatively low temperature conditions, significantly reducing the damage of high temperature to surrounding healthy tissues. It also has the ability to specifically recognize tumor lesions, achieving high enrichment at the tumor site and enhancing the therapeutic effect.

The present invention relates to the field of medical therapy of lesions detrimental to a body. The system is capable of treatment with a non-invasive, ionizing kV energy radiation source. Locally focused energy can be used to definitively treat, or as an adjuvant to enhance immune modulators, to eliminate tumors. Distributed external beam entry points produce a significant advantageous dose profile at depth as intersecting beams accumulate in a narrow focus to treat a selected volume. Targeted disease may have enhanced sensitivity to the radiation by taking up an ionizing-radiation, treatment-localizing agent. This increases the effectiveness of an energy dose in the lesion. The pattern of beam output is effectively directed towards a desired location and kV x-rays traveling towards undesired locations, such as healthy tissue, are quenched. Targeting a lesion within the body with volumetrically discrete energy dose deposition can beneficially impact harmful lesions. Aiming the beam at a pathologic target is done while moving an x-ray source mechanically around a patient to distribute surface dose. The purpose of the focused energy deposition is to destroy and disable pathologic physiology, such as malignant masses. More specifically this invention relates to a system, which optimizes delivery of ionizing kV beams to a lesion alone or one containing treatment-localizing agents in higher concentration than the surrounding normal tissues. Thereby an optimal delivery of ionizing radiation becomes more destructive to a mass of abnormal cells upon interaction with the targeted site.

The invention relates to the technical field of vascular interventional therapy instruments, and discloses an excimer laser ablation system and method for restenosis after Budd-Chiari syndrome interventional therapy, the excimer laser ablation system comprises a controller, a pulse transmitting module and a reference element arranged in a catheter, and the system performs periodic self-calibration based on the reference element; according to the method, associated photoacoustic signals are collected and processed to identify tissue types, selective ablation of lesion tissues and boundary self-stop when healthy tissues are touched are further achieved, traditional open-loop energy delivery is converted into a closed-loop self-control process with real-time information interaction capacity, and the method has the advantages of being simple in structure, convenient to operate and high in practicability. The ablation operation tail end can sense the tissue boundary in situ and achieve automatic stopping, so that the problem that healthy tissue is damaged due to uncontrollable energy application is solved, the safety of an operation is improved, and the advantages of being high in precision, few in complication, capable of achieving repeated treatment and the like are achieved.

The invention relates to the technical field of focused ultrasound treatment, in particular to a real-time feedback phased array focused ultrasound treatment system, which comprises the following steps of: 1, fixing integrated equipment of ultrasonic transducers and EIT electrodes which are alternately and annularly arranged on a head, acquiring a three-dimensional image of the head by using imaging technologies such as CT or MRI and the like, and marking the spatial positions of the electrode, the ultrasonic array and the treatment target spot on the image. According to the invention, brain region real-time three-dimensional electrical impedance imaging is used as feedback, the excitation time sequence, intensity and phase of the ultrasonic array are adaptively adjusted, the influence of skull structure difference on ultrasonic focusing can be effectively overcome, the system calculates the phase shift of the ultrasonic array in real time, it is ensured that an ultrasonic beam is accurately focused at a treatment target, and the treatment accuracy is improved. The device is particularly suitable for a patient with a complex skull structure, the treatment accuracy is improved, it is ensured that ultrasonic energy accurately acts on a lesion area, and damage to surrounding healthy tissue is avoided.

This invention discloses an adjustable pressure constant temperature wound irrigation device, belonging to the field of wound irrigation technology. It includes a constant temperature water tank, with a first connecting pipe fixedly connected to the output end of the water tank. A water pump is installed at one end of the first connecting pipe, and a second connecting pipe fixedly connected to the output end of the water pump. A fixed support is fixedly connected to the bottom of the second connecting pipe. A wound adaptor is also included, with the pressure adaptor disposed inside the fixed support for adapting to wounds of different lengths and adjusting the extension length of the water outlet. This invention, by incorporating a wound adaptor and precisely controlling the extension distance of the spray nozzle to match the wound length through motor start / stop, ensures that the irrigation water flow targets and covers the entire wound area, guaranteeing comprehensive and effective irrigation while avoiding irritation of surrounding healthy tissue. It also replaces manual adjustment, improving the accuracy, controllability, and standardization of operation, while reducing patient discomfort and balancing the effectiveness and comfort of the treatment procedure.

The invention relates to the technical field of minimally invasive medical treatment, and discloses an endoscope and an endoscope sheath water jet scalpel treatment system, comprising: an insertion part in which a camera system and a light source are integrated; the tubular endoscope sheath can accommodate the insertion part, the near end of the tubular endoscope sheath is provided with a connecting port communicated with a negative pressure pump, and the far end of the tubular endoscope sheath is a transparent blind end; the adsorption ports are distributed in the circumferential direction of the side wall of the endoscope sheath, and the adsorption ports and the connecting port form a negative pressure channel through an inner cavity of the sheath tube; the water jet scalpel assembly comprises a water inlet pipe which rotatably penetrates through the jaw opening of the insertion part, and a return pipe which is arranged in the inner cavity of the sheathing canal; the far end of the water inlet pipe is provided with a high-pressure water nozzle, and the near end is connected with the water jet system. A focus is accurately positioned under the guidance of a high-definition image, targeted adsorption is realized by utilizing the physical property difference of tissues and forming a dynamic negative pressure field through a spiral adsorption port, and adsorption force is regulated and controlled to enhance pathological tissue capture and inhibit healthy tissue traction, so that the debridement efficiency is improved, the complication occurrence rate is remarkably reduced, and the safety of minimally invasive treatment of a cavity is ensured.

The invention discloses a soluble microneedle patch for skin tumors and a preparation method and application thereof, and belongs to the technical field of soluble microneedles, gel formed by a microneedle matrix which is excellent in biocompatibility and contains disulfide bonds is injected into a microneedle mold, and the soluble microneedle patch is prepared. Then vacuumizing, centrifuging, adding viscous microneedle substrate polyacrylic acid gel, and drying to obtain the specific soluble microneedle patch of which the dissolution rate in a tumor microenvironment is obviously higher than that of normal tissues. The microneedle matrix with disulfide bonds specifically responds to the high reducibility of a tumor microenvironment, the drug is rapidly broken and released, the drug release amount in a normal skin area is reduced, stimulation to healthy tissue is avoided, potential damage to normal tissue is reduced, and more accurate targeted therapy is achieved.