120 results about "Healthy tissue" patented technology

The invention discloses a medical image fuzzy boundary segmentation method based on an edge perception Mama network. The method aims at solving the problems that a camouflage pathological structure in a medical image is visually similar to surrounding healthy tissues, so that segmentation is difficult, and clinical deployment is difficult due to secondary calculation complexity of an attention mechanism in a traditional camouflage target detection (COD) method. According to the invention, a boundary guiding module inspired by COD is creatively combined with linear complexity state space modeling, and an E-Mama edge guiding framework is provided. The framework adopts an encoder-edge guide-decoder structure, and accurate boundary description is realized while the computational efficiency is kept. The system comprises five core components: a Mama encoder; an adaptive fusion processing module (AFM); an edge detection module (EDM); an edge guidance module (EGM); the invention relates to a Mama decoder. Experiments show that advanced segmentation precision is realized on a plurality of medical data sets, and meanwhile, the calculation complexity is reduced from O (n2) to O (n), so that clinical deployment becomes possible.

Radiotherapy is the most widely used and effective anti-tumor therapy, however it can damage healthy tissues surrounding the tumor. One approach to reducing damage to healthy tissue involves irradiation at dose rates far exceeding those currently used in clinical contexts reduces radiation-induced toxicities while maintaining an equivalent tumor response. This is known as the FLASH effect. The mechanism responsible for reduced tissue toxicity following FLASH radiotherapy (FLASH-RT) is still undetermined; multiple hypotheses have been suggested by linking the high dose rate to rapid oxygen depletion, immune response, reduction of peroxyl radical lifetime, preservation of normal tissue stem cells, etc. While effective, proton therapy is underutilized, contributing to fewer than 2% of all external beam radiation treatments. To overcome this shortcoming, provided are methods which utilize the highest energy layer and a universal range shifter (URS) to facilitate rapid spot arc therapy (RAPIDSPARC™).

The invention discloses a self-adaptive control system based on a cutting anastomat, and relates to the technical field of medical instrument control, and the system comprises an intelligent hardware module which is used for analyzing a motion control instruction based on an MCU (Microprogrammed Control Unit), receiving a PWM (Pulse Width Modulation) signal by a DC motor driver, and starting a tool bit to advance according to a preset acceleration curve; the TACS module analyzes the tissue state based on sensor data and dynamically adjusts the rotating speed and cutting force of a motor; and the man-machine interaction visualization module is used for carrying out visual and clear graphical and digital presentation, including electric quantity, anastomosis pressure and cutting progress, on the basis of an electronic display screen. The MCU serves as the core, the tool bit is controlled to advance according to the preset curve through PWM signals, it is ensured that the cutting action is accurate and stable, the equipment loss and the tissue damage risk are reduced, the TACS module analyzes the tissue state in real time and dynamically adjusts the motor rotating speed and the cutting force through a sensor, the cutting effect can be ensured for tissue with different hardness and thickness, and the cutting efficiency is improved. Healthy tissues can be protected, and the operation safety and efficiency are improved.

The invention discloses a tumor radiotherapy non-irradiation area protection device, and relates to the cervical cancer radiotherapy protection field, and the tumor radiotherapy non-irradiation area protection device comprises a mounting frame, and the interior of the mounting frame is fixedly connected with a first telescopic driving member. The first moving mechanism and the second moving mechanism can respectively drive the moving frame and the adjusting plate to move back and forth and left and right, so that the through hole is accurately positioned to the radiotherapy position of the cervical cancer patient. The first rotation driving piece can drive the adjusting lead plate to rotate, so that the adjusting holes with proper sizes are aligned with cancer cells. The blocking adjusting mechanism further optimizes protection, and when a gap exists between the adjusting hole and the cancer cells, the driving mechanism drives the transmission ring to rotate, so that the second telescopic driving piece drives the pushing block to push the lead block plate to move, and the gap is filled. Thus, the first lead plate, the second lead plate and the adjusting lead plate act together to ensure that radiotherapy rays irradiate cancer cells only through the adjusting holes, so that the rays are effectively prevented from damaging surrounding healthy tissues, and adverse effects of radiotherapy on patients are reduced.

The invention discloses a hyperspectral imaging-based rice blast early diagnosis method, and relates to the technical field of agricultural disease monitoring, and the specific steps of the method are as follows: S100, obtaining spectral data of rice in a region, S200, constructing a healthy tissue end member spectrum and predicting a lesion tissue end member spectrum, S300, constructing a mixed pixel model, and combining constraint conditions to determine the early diagnosis of rice blast. According to the method, through the mixed pixel model of the time sequence dynamic end members, the fine change of the spectrum can be accurately captured in the early stage of rice blast infection, through continuous time sequence hyperspectral imaging, the real-time spectrum of the rice blast can be accurately captured, and the real-time spectrum of the rice blast can be obtained. And learning dynamic evolution of a lesion end member spectrum by combining an LSTM network, regarding a mixed pixel at each time point as a mixture of a healthy tissue end member spectrum and a gradually evolved lesion tissue end member spectrum, and inverting the state and abundance of the lesion tissue end member spectrum at each time point so as to quantitatively monitor the early development progress of infection.

The invention discloses a radioactive medical isotope Ra-223 stably-labeled rare earth nano diagnosis and treatment preparation as well as a preparation method and application thereof. According to the invention, by constructing a dual protection mechanism of the shell layer and the functional biomolecular layer, the Ra-223 is effectively packaged, the recoil nuclei of the Ra-223 are reserved at the tumor part and are prevented from escaping to the surrounding environment of the tumor, the safety of the Ra-223 treatment process can be enhanced, the radioactive energy is ensured to accurately act on the focus, and the treatment effect of the Ra-223 is improved. Meanwhile, the damage risk to healthy tissues is minimized.

The present technology can be used to selectively heat one or more diseased regions in the lung while limiting heating of healthy regions and surrounding tissue. This heating provides a therapeutic effect. Selective heating of diseased tissue can be achieved by exposing the lung to an electromagnetic field to cause dielectric or eddy current heating. The present technology is particularly useful for treating emphysema because the diseased regions of emphysema patients have reduced blood flow. The diseased regions will heat up quickly while healthy tissue will be cooled by blood flow. This is particularly effective for treating emphysema because the lung has a small mass and high blood flow. In one described embodiment, the frequency of the electromagnetic radiation is chosen to satisfy certain resonance conditions of the device. In another described embodiment, a coil is used to apply the electromagnetic radiation, the geometric parameters of the coil being chosen so that an electric field maximum is produced in the region to be heated. In another described embodiment, a pair of electromagnetic energy signal applicators are used to apply the electromagnetic radiation, the pair of electromagnetic energy signal applicators being positioned to surround the torso of the patient, one electromagnetic energy signal applicator being positioned cephalad relative to the treatment region and the other electromagnetic energy signal applicator being positioned caudal relative to the treatment region, and the pair of electromagnetic energy signal applicators being shaped to encircle or partially encircle the periphery of the torso.

The scalpel comprises a first scalpel handle and a first scalpel head, the first scalpel head is detachably arranged at the front end of the first scalpel handle, a connecting insertion block is arranged at the front end of the first scalpel handle, and a step-shaped clamping groove is formed in the outward end of the connecting insertion block; the tail end of the first tool bit is provided with a connecting groove matched with the stepped clamping groove and the connecting inserting block in appearance, the front end of the first tool bit is provided with an integrally-formed extending part, the extending part is bent outwards, and the width of the end is gradually reduced to form a tip in the outward extending process of the extending part. Blades are arranged on the two side surfaces of the extension part; the extension part which is bent outwards can be suitable for narrow and irregular spaces around wisdom teeth, especially at different tooth position angles, and can be conveniently inserted into a gap between a gingiva and an alveolar bone, so that the connection between the gingiva and a dental crown neck as well as between the gingiva and an alveolar is completely cut and separated, and the end part of the extension part is a sharp end; and accurate puncture and combination of the starting point of the epithelium are facilitated, and damage to healthy tissues is reduced.

The invention relates to a high frequency magnetic induction device (100). The device (100) comprises magnetic nanosuspension (101) and an AMF generator (103). The AMF generator (103) further comprises copper induction coil (104), work head (105), flexible connector (106), power supply (107), chiller (108), display and control unit (109), fiberoptic thermometer sensors (110a &110b), auto-manual toggle switch (111), USB port (112a &112b) and bed support (113). Tumor site enclosed by the magnetic nanosuspension (101) comprising iron oxide magnetic nanoparticles (102) generates heat when exposed to AMF generated by the AMF generator (103). The heat generated does not cause any harm to the healthy tissues. The AMF generator (103) has precise control over thermal doses generated. The high frequency induction device (100) is safe, effective, non-invasive with mild side-effects.

The present application relates to the technical field of vascular interventional treatment instruments, and discloses a system and method for the selective laser ablation of restenosis after the treatment of Budd-Chiari syndrome, comprising a controller, a pulse emission module and a reference element built into a catheter, the system is based on the reference element for periodic self-calibration, collects and processes the associated photoacoustic signals to identify the tissue type, and then realizes the selective ablation of the diseased tissue and the boundary self-stop when the healthy tissue is touched. The present application converts the traditional open-loop energy delivery into a closed-loop self-control process with real-time information interaction capability, so that the ablation operation end can in-situ perceive the tissue boundary and realize autonomous stop, thereby avoiding the problem of damaging the healthy tissue due to uncontrollable energy application, improving the safety of the operation, and having the advantages of high precision, few complications, repeatable treatment and the like.

Systems and methods of predicting microcalcification activity in a vascular vessel comprising either an artery or a vein, comprising the steps of: (a) measuring patient data comprising one or more of: the existence of and / or quantity of coronary plaques or visible markers of disease in a vascular tissue sample; the existence of and / or quantity of healthy tissue in the vascular tissue sample; one or more features that define an abnormal hemodynamic environment in a vessel; one or more geometric features that are associated with vascular remodeling and which influence hemodynamics in a vessel, and / or one or more material properties that influence vascular hemodynamics; and (b) calculating the microcalcification activity in the vessel as a function of the measurements taken in Step (a).

Various examples of the disclosure pertain to using whole-slide images that depict healthy tissue for a training process for at least one machine-learning algorithm for digital pathology. For instance, an autoencoder neural network can be trained based on the healthy tissue.

Broadly speaking, the present techniques generally relate to a method for processing images of an organ (or part thereof) using a trained machine learning, ML, model in order to more efficiently and accurately provide information on different tissue regions of the organ. Advantageously, the ML model generates an augmented image of the organ showing the different tissue regions, such as diseased tissue regions and healthy tissue regions. This may help a surgeon to decide where to perform a surgical intervention in a way that only diseased tissue is excised.

This invention discloses a multifunctional tumor-targeted cryotherapy nanoplatform and its applications, belonging to the field of nanobiomedicine technology. The multifunctional tumor-targeted cryotherapy nanoplatform of this invention uses two-dimensional Ti3C2 nanomaterials as a carrier, loaded with indocyanine green as a photosensitizer, surface-modified with polydopamine to improve stability, and loaded with gambogeylic acid as an anti-tumor drug and a heat shock protein inhibitor. It is covalently coupled with nucleic acid aptamers that can recognize cell surface-specific proteins. The multifunctional tumor-targeted cryotherapy nanoplatform has small particle size, high dispersion, and good biocompatibility, and exhibits excellent photothermal conversion ability, photodynamic therapy effect, and chemotherapy effect in tumor-targeted therapy. It can effectively induce tumor cell apoptosis under relatively low temperature conditions, significantly reducing the damage of high temperature to surrounding healthy tissues. It also has the ability to specifically recognize tumor lesions, achieving high enrichment at the tumor site and enhancing the therapeutic effect.

The present invention relates to the field of medical therapy of lesions detrimental to a body. The system is capable of treatment with a non-invasive, ionizing kV energy radiation source. Locally focused energy can be used to definitively treat, or as an adjuvant to enhance immune modulators, to eliminate tumors. Distributed external beam entry points produce a significant advantageous dose profile at depth as intersecting beams accumulate in a narrow focus to treat a selected volume. Targeted disease may have enhanced sensitivity to the radiation by taking up an ionizing-radiation, treatment-localizing agent. This increases the effectiveness of an energy dose in the lesion. The pattern of beam output is effectively directed towards a desired location and kV x-rays traveling towards undesired locations, such as healthy tissue, are quenched. Targeting a lesion within the body with volumetrically discrete energy dose deposition can beneficially impact harmful lesions. Aiming the beam at a pathologic target is done while moving an x-ray source mechanically around a patient to distribute surface dose. The purpose of the focused energy deposition is to destroy and disable pathologic physiology, such as malignant masses. More specifically this invention relates to a system, which optimizes delivery of ionizing kV beams to a lesion alone or one containing treatment-localizing agents in higher concentration than the surrounding normal tissues. Thereby an optimal delivery of ionizing radiation becomes more destructive to a mass of abnormal cells upon interaction with the targeted site.

The invention relates to the technical field of vascular interventional therapy instruments, and discloses an excimer laser ablation system and method for restenosis after Budd-Chiari syndrome interventional therapy, the excimer laser ablation system comprises a controller, a pulse transmitting module and a reference element arranged in a catheter, and the system performs periodic self-calibration based on the reference element; according to the method, associated photoacoustic signals are collected and processed to identify tissue types, selective ablation of lesion tissues and boundary self-stop when healthy tissues are touched are further achieved, traditional open-loop energy delivery is converted into a closed-loop self-control process with real-time information interaction capacity, and the method has the advantages of being simple in structure, convenient to operate and high in practicability. The ablation operation tail end can sense the tissue boundary in situ and achieve automatic stopping, so that the problem that healthy tissue is damaged due to uncontrollable energy application is solved, the safety of an operation is improved, and the advantages of being high in precision, few in complication, capable of achieving repeated treatment and the like are achieved.

The invention relates to the technical field of focused ultrasound treatment, in particular to a real-time feedback phased array focused ultrasound treatment system, which comprises the following steps of: 1, fixing integrated equipment of ultrasonic transducers and EIT electrodes which are alternately and annularly arranged on a head, acquiring a three-dimensional image of the head by using imaging technologies such as CT or MRI and the like, and marking the spatial positions of the electrode, the ultrasonic array and the treatment target spot on the image. According to the invention, brain region real-time three-dimensional electrical impedance imaging is used as feedback, the excitation time sequence, intensity and phase of the ultrasonic array are adaptively adjusted, the influence of skull structure difference on ultrasonic focusing can be effectively overcome, the system calculates the phase shift of the ultrasonic array in real time, it is ensured that an ultrasonic beam is accurately focused at a treatment target, and the treatment accuracy is improved. The device is particularly suitable for a patient with a complex skull structure, the treatment accuracy is improved, it is ensured that ultrasonic energy accurately acts on a lesion area, and damage to surrounding healthy tissue is avoided.

This invention discloses an adjustable pressure constant temperature wound irrigation device, belonging to the field of wound irrigation technology. It includes a constant temperature water tank, with a first connecting pipe fixedly connected to the output end of the water tank. A water pump is installed at one end of the first connecting pipe, and a second connecting pipe fixedly connected to the output end of the water pump. A fixed support is fixedly connected to the bottom of the second connecting pipe. A wound adaptor is also included, with the pressure adaptor disposed inside the fixed support for adapting to wounds of different lengths and adjusting the extension length of the water outlet. This invention, by incorporating a wound adaptor and precisely controlling the extension distance of the spray nozzle to match the wound length through motor start / stop, ensures that the irrigation water flow targets and covers the entire wound area, guaranteeing comprehensive and effective irrigation while avoiding irritation of surrounding healthy tissue. It also replaces manual adjustment, improving the accuracy, controllability, and standardization of operation, while reducing patient discomfort and balancing the effectiveness and comfort of the treatment procedure.

The invention relates to the technical field of minimally invasive medical treatment, and discloses an endoscope and an endoscope sheath water jet scalpel treatment system, comprising: an insertion part in which a camera system and a light source are integrated; the tubular endoscope sheath can accommodate the insertion part, the near end of the tubular endoscope sheath is provided with a connecting port communicated with a negative pressure pump, and the far end of the tubular endoscope sheath is a transparent blind end; the adsorption ports are distributed in the circumferential direction of the side wall of the endoscope sheath, and the adsorption ports and the connecting port form a negative pressure channel through an inner cavity of the sheath tube; the water jet scalpel assembly comprises a water inlet pipe which rotatably penetrates through the jaw opening of the insertion part, and a return pipe which is arranged in the inner cavity of the sheathing canal; the far end of the water inlet pipe is provided with a high-pressure water nozzle, and the near end is connected with the water jet system. A focus is accurately positioned under the guidance of a high-definition image, targeted adsorption is realized by utilizing the physical property difference of tissues and forming a dynamic negative pressure field through a spiral adsorption port, and adsorption force is regulated and controlled to enhance pathological tissue capture and inhibit healthy tissue traction, so that the debridement efficiency is improved, the complication occurrence rate is remarkably reduced, and the safety of minimally invasive treatment of a cavity is ensured.

The invention discloses a soluble microneedle patch for skin tumors and a preparation method and application thereof, and belongs to the technical field of soluble microneedles, gel formed by a microneedle matrix which is excellent in biocompatibility and contains disulfide bonds is injected into a microneedle mold, and the soluble microneedle patch is prepared. Then vacuumizing, centrifuging, adding viscous microneedle substrate polyacrylic acid gel, and drying to obtain the specific soluble microneedle patch of which the dissolution rate in a tumor microenvironment is obviously higher than that of normal tissues. The microneedle matrix with disulfide bonds specifically responds to the high reducibility of a tumor microenvironment, the drug is rapidly broken and released, the drug release amount in a normal skin area is reduced, stimulation to healthy tissue is avoided, potential damage to normal tissue is reduced, and more accurate targeted therapy is achieved.

This application relates to the field of medical devices and discloses a wound cleaning device for orthopedic care. The device includes a cleaning bed; a drainage pipe disposed at the bottom of the cleaning bed; a pump assembly and a reciprocating sliding assembly disposed on the cleaning bed; an arc-shaped cleaning disc disposed within the reciprocating sliding assembly and communicating with the pump assembly; detection components disposed on both sides of the arc-shaped cleaning disc; a drive assembly, a positioning assembly, and a dispensing assembly disposed within the arc-shaped cleaning disc, with the drive assembly connected to the positioning assembly; the dispensing assembly contains multiple arc-shaped baffles, a lifting assembly, and a pulse cleaning assembly; and a conversion assembly disposed within the drive assembly. This cleaning device allows for convenient activation of the corresponding drive assembly to form a medication path based on the wound area, preventing medication from spraying onto surrounding healthy tissue, reducing medication waste, and minimizing patient discomfort.

A method includes receiving one or more radiological images of an anatomy of a patient. The method also includes identifying a boundary of different tissue types in the anatomy of the patient based at least partially upon the one or more radiological images. The method also includes identifying one or more regions within the boundary. The one or more regions include a lung region. The method also includes identifying healthy tissue and COVID-19 tissue in the lung region. The method also includes quantifying an extent of the COVID-19 tissue in the lung region by comparing an amount of the COVID-19 tissue in the lung region to an amount of the healthy tissue in the lung region. The method also includes classifying the extent of the COVID-19 tissue in the lung region into one or more of a plurality of COVID-19 classes.

The invention relates to the technical field of medical image processing and tumor treatment planning, and discloses a tumor ablation assessment method based on clustering and dynamic weight Monte Carlo sampling, and the method comprises the steps: dividing a tumor, i.e., a healthy region, through spatial clustering, optimizing sample distribution in combination with an error feedback mechanism related to a region density compensation factor, and obtaining a tumor ablation result; introducing a momentum enhanced weight updating strategy, correcting sparse region sampling deviation, adaptively balancing historical errors, rapidly judging a sample membership relationship through an ablation ellipsoid model, and synchronously calculating a tumor ablation coverage rate and a healthy tissue damage rate; the tumor ablation coverage rate and the healthy tissue damage rate can be rapidly, stably and accurately calculated synchronously, and a reliable quantitative basis is provided for real-time planning in an operation and accurate evaluation after the operation.

New compositions and methods are described herein operable for delivery of therapeutic agents while mitigating damage to healthy tissues. In one aspect, a conjugate comprises a linker joining a pharmaceutical component and a targeting ligand, wherein the linker is at least one of radiolabile, photolabile, thermolabile, chemically labile, magnetically labile, or acoustolabile for release of the targeting ligand and / or the pharmaceutical component from the conjugate.

The invention provides an energy type robot treatment system and method for AI driving, the system comprises a robot arm, a multi-mode sensor kit and an AI control unit, and an end effector capable of generating treatment energy is installed at the tail end of the robot arm. A trained machine learning model on an AI control unit is used for processing real-time data collected by a multi-mode sensor suite from a treatment part, and the machine learning model is combined with pre-loaded patient data to generate a predictive control signal; the AI-driven control can achieve accurate and selective ablation of cancer tissue while minimizing incidental damage to surrounding healthy tissue, so as to improve the therapeutic effect, by dynamically adjusting the therapeutic parameters and height position parameters of the end effector.

The utility model belongs to the technical field of debridement devices, and particularly relates to a clinical debridement device which comprises a movable body. Arc-shaped groove plates are symmetrically and fixedly installed at the top end of the movable body, a snakelike lamp and a faucet are fixedly installed on one side of the movable body, water collecting grooves are installed at the bottom end of the faucet, the water collecting grooves are symmetrically installed on one sides of the arc-shaped groove plates, and the water collecting grooves are slidably installed at the top end of the movable body. A fixing assembly for fixing a wound of a patient is arranged between the water collecting tanks; by arranging the fixing assembly, when a wound of a patient needs to be cleaned, the problem that when the wound of the patient is cleaned, the wound is prone to unnecessary movement due to water flow impact, the accuracy and efficiency of water flow debridement are reduced, and the debridement effect is reduced is solved, the accuracy and efficiency of debridement are improved, and the debridement efficiency is improved. Potential damage to surrounding healthy tissue is reduced, in addition, wound fixing is beneficial for maintaining cleanliness of a treatment area, and secondary pollution is prevented.

The application relates to the technical field of medical systems, in particular to an AI-assisted precise ablation operation robot, and the technical scheme acquires tissue information on a track, fluctuation characteristics of organs and path track information through a data acquisition terminal, analyzes ablation risks and tissue risks caused by the fluctuation characteristics of the organs on the path track and the tolerance characteristics of the tissue information, and evaluates the track risks by comprehensively analyzing the ablation risks and the tissue risks, so that the ablation path is optimized through multi-modal data fusion and dynamic risk evaluation, the damage risk to surrounding healthy tissues is reduced while ensuring sufficient coverage of a lesion, and the core innovation lies in layered quantification of ablation risks and tissue risks caused by organ fluctuation, so that safer and more precise ablation treatment is realized.

The present invention relates to a non-invasive magneto-acoustic apparatus for healthy tissue healing and cancer regression comprising at least one pulsed ultrasound unit (LIPUS), at least one permanent magnet, at least one module housing, at least one permanent magnets, at least one control system for controlling pulsed ultrasound unit to energize the unit with desired pulse duration, intensity and active / ON time. The invention is to synchronously use the low intensity pulsed ultrasound (LIPUS) and static magnetic field (SMF) to selectively activate cellular activities specific to cartilage, bone, skin leading to accelerated tissue healing, regeneration. The invention apparatus is to inhibit cancer cellular activities specific to cancers of breast, skin, bone leading to enhanced cancer regression, while leaving the healthy cells unaffected using magneto-acoustic apparatus appropriately. The apparatus exhibit no toxicity to healthy cells and can reduce overall treatment time and costs due to accelerated tissue repair and tumor regression.

The utility model discloses interventional equipment. The interventional equipment comprises a needle seat, a needle head and a needle head, the needle body is fixedly arranged on the needle seat; the first channel penetrates through the needle base and the needle body, and the first channel is used for an interventional surgical instrument to penetrate through; the second channel penetrates through the needle base and the needle body, the second channel and the first channel are mutually independent, and the second channel is used for allowing a navigation sensor to penetrate; the two ends of the limiting connector are used for being connected with an interventional surgical instrument and the needle base respectively so as to control the movement amount of the interventional surgical instrument in the interventional direction along the first channel. According to the interventional surgical instrument, the interventional process of the interventional surgical instrument is navigated, the position of the front end of the interventional surgical instrument can be accurately obtained in the interventional process, and surgical operation can be facilitated; and the influence of the front end of the interventional surgical instrument on the navigation sensor and healthy tissues in the surgical process can be reduced.

The application discloses a kind of health multi-phase image guided multi-phase lesion image segmentation methods, this method mainly includes: using healthy multi-phase contrast-enhanced CT training deep learning network, freeze its parameters, then send lesion CT image into trained healthy image network and another network structure consistent with the lesion image network to be trained.Healthy image network acts as normal tissue feature extractor, assist lesion image network training;Wherein, the loss function of healthy image network adopts the combination of Dice loss function and cross-entropy loss function, the loss function of lesion image network includes the mean square error loss function of feature map extracted by healthy image network and lesion image network to lesion image in addition to above-mentioned two loss functions.The application scheme distinguishes healthy tissue and lesion tissue by guiding lesion image network with healthy image, and the segmentation precision of lesion tissue is improved.