76 results about "Parenchyma" patented technology

The invention discloses an intelligent chest CT image processing system which comprises an image acquisition module, a multi-scale filtering processing module, a frequency domain edge enhancement module, an edge fusion correction module, an enhancement loss design module, a chest CT image segmentation model establishment module and a chest CT image processing module. The invention belongs to the field of image processing, and particularly relates to an intelligent chest CT (computed tomography) image processing system, which is characterized in that differentiated processing is performed in different frequency spectrum sections according to noise characteristics, key points are guided to be reserved, and blood vessel walking is enhanced; through edge fusion correction, adaptive reinforcement of small-range nodules and large-range lesions is considered; the branch A is used for refining the nodule edge and artifact weak contrast, and the branch B is used for strengthening the lung lobe macroscopic consistency; the decoding layer inhibits a learned region, focuses a blood vessel and a lung parenchyma junction through interface focusing; the loss is introduced into boundary smoothing, the overall segmentation contour is optimized, and false positive burr-shaped noise is reduced; and the chest CT image processing accuracy is improved.

The invention discloses an active / inactive pulmonary tuberculosis recognition system based on an improved 3D network, and the system comprises an image feature obtaining module which is used for obtaining pulmonary tuberculosis CT chest image features; the data preprocessing module is used for carrying out data preprocessing on the obtained pulmonary tuberculosis CT chest image features; the image segmentation module is used for segmenting the preprocessed pulmonary tuberculosis CT chest image features to obtain pulmonary parenchyma image features, and an adopted segmentation model is a 3D ResUNet segmentation model; the image classification and recognition module is used for performing prediction and classification on the lung parenchyma image features after image segmentation; wherein the adopted image classification model is a 3D ResUNet50 classification model, and the 3D ResUNet50 classification model is combined with a multi-scale attention module to obtain image output features; then, image output features are processed by adopting grouping convolution and channel shuffling, the types of active and inactive pulmonary tuberculosis are predicted, and confidence scores of the model are generated; the CT image classification accuracy of the model can be improved.

Modular mucosal tissue bioreactors combined with bioartificial mucus provide a high-fidelity, medium-throughput platform for evaluating CF treatments and modeling host-pathogen biology, a stepping stone towards better options for HEMT-nonresponsive patients. Whole lung ex vivo Cystic Fibrosis model system allows for investigation of candidate CF therapies.

The invention provides an interpretable wood identification method and device. The method comprises the following steps: detecting a construction structure of a wood image by using a construction feature detection model; the construction structure comprises a pipe hole, a wood ray and a parenchyma structure, and provides image evidence for an identification result; quantifying the pipe hole, the wood ray and the parenchymal tissue to obtain an IAWA feature code corresponding to the tectonic tissue, and providing anatomical evidence for an identification result; fusing the IAWA feature codes of the plurality of wood images of the same wood to obtain a fused feature vector; and inputting the fusion feature vector into a Bayesian classification model, and performing reasoning and classification by using the Bayesian classification model to obtain a wood classification result. According to the method provided by the invention, while the wood classification result is obtained, the image construction annotation, the feature statistical result and the IAWA feature code can be given, the classification result has the wood interpretability, and the credibility of the classification result in wood research and practical application is improved.

The invention belongs to the technical field of biological medicines, and particularly relates to application of small interfering RNA (Ribonucleic Acid) of a targeted Zyx gene. The invention provides siRNA (small interfering Ribonucleic Acid) of a targeted Zyx gene, and further provides application of the siRNA in prevention and treatment of fibrosis interstitial lung diseases. Experimental data prove that in a mouse bleomycin model, siRNA of a targeted Zyx gene can effectively improve the survival rate of a sick mouse, alveolar wall thickening, lung substantive thickening and inflammatory cell infiltration of a Zyx knock-down group are not obvious, and pathological damage caused by bleomycin is effectively relieved through knock-down of the Zyx gene; collagen fiber deposition of a Zyx knock-down group is reduced, and the transcription level of fibrosis-related genes is obviously reduced.

The invention relates to the technical field of medical informatics, and provides an interstitial lung disease HRCT image analysis method and system based on artificial intelligence. The method comprises the following steps: performing pulmonary parenchyma segmentation processing on an input HRCT image to obtain a pulmonary parenchyma region; performing multi-category lesion segmentation on the pulmonary parenchyma region to obtain a segmentation mask; performing quantitative calculation on lesion distribution characteristics according to the segmentation mask to obtain lesion distribution parameters; and carrying out image mode classification according to the segmentation mask and the lesion distribution parameters to obtain a classification result. According to the method, the efficiency and precision of HRCT image analysis are improved, and the application range of HRCT image analysis is expanded.

The present disclosure relates to an approach, referred to as Regionally Activated Interstitial Drugs (RAID), that does not require viral vectors, but allows for tunable, noninvasive, long-term neuromodulation with small molecules. RAID utilizes noninvasive delivery of an engineered protein enzyme into the brain, which then binds to the brain parenchyma and can locally convert a blood-brain-barrier (BBB)-permeable inert prodrug into an active neuromodulatory drug. As long as the RAID enzyme is present in the parenchyma, localized neuromodulation can be achieved with systemic administration of the BBB-permeable prodrug even in the absence of the opened BBB. Alternatively, gene delivery encoding the RAID enzyme offers prolonged expression and precise spatial control, enabling long-term and adaptable neuromodulation.

The invention provides a kidney ultrasonic image analysis system and method, and the method comprises the steps: extracting the structural features of a kidney parenchyma region from a collected B-mode ultrasonic image sequence, and extracting the blood flow features of a corresponding region from a collected color Doppler blood flow image sequence; determining a blood flow distribution index diagram reflecting kidney blood flow distribution according to the blood flow characteristics, and then performing regional adaptive enhancement on the B-mode ultrasonic image sequence through the blood flow distribution index diagram to generate a B-mode reference image with an enhanced signal-to-noise ratio and a prominent skin medullary boundary; and fusing the B-mode reference image with a peak blood flow distribution diagram generated from the blood flow image sequence to obtain a fusion enhanced image when kidney skin marrow segmentation is performed on the kidney of the target patient. By adopting the scheme of the invention, pixel-level fusion can be carried out on the B-mode ultrasonic image and the color Doppler blood flow image based on the blood flow distribution in the color Doppler blood flow image.

The present application relates to the technical field of lung image marking auxiliary reading, in particular to an auxiliary reading system suitable for lung cryptococcosis patients. The present application firstly acquires continuous CT slice images of the lung, and extracts the foreground connected domain of the lung parenchyma region as the connected domain to be analyzed; further, according to the monotonicity of the width change of the target connected domain, the blood vessel possibility of the target connected domain is acquired; further, according to the monotonicity of the area change of the connected domain to be analyzed at the same position, the possibility of the target connected domain penetrating through the blood vessel is acquired; the degree of the target connected domain being similar to a circle is acquired; finally, according to the degree of being similar to a circle, the blood vessel possibility and the possibility of penetrating through the blood vessel are fused, and the target connected domain is marked. The present application measures the possibility of the target connected domain belonging to the blood vessel from the width change and the area change, and fuses the blood vessel possibility and the possibility of penetrating through the blood vessel by means of the degree of being similar to a circle, so as to accurately mark the connected domain and assist the relevant personnel in reading.

Systems and methods for controlled sympathectomy procedures for neuromodulation are disclosed. A system for controlled micro ablation procedures is disclosed. A guidewire including one or more sensors or electrodes for accessing and recording physiologic information from one or more anatomical sites within the parenchyma of an organ as part of a physiologic monitoring session, a diagnostic test, or a neuromodulation procedure is disclosed. A guidewire including one or more sensors and / or a means for energy delivery, for performing a neuromodulation procedure within a small vessel within a body is disclosed.

This document describes devices for in vivo drug testing in the brain. This document also describes implantable devices for long-term drug delivery to the brain parenchyma, and for access to biomarkers from the parenchyma.

The invention relates to a method and a device for automatically identifying benign and malignant kidney cystic lesions based on magnetic resonance images. The method comprises the following steps: S1, preprocessing and standardizing a T2 weighted image, a diffusion weighted image, an apparent diffusion coefficient image, a T1 weighted image, a skin medullary phase image, a parenchyma phase image and an excretion phase image; s2, respectively training automatic segmentation models corresponding to different images in a targeted manner, and predicting a focus by using the automatic segmentation models; s3, extracting morphological features, first-order features and textural features of the lesions from all the lesions, wherein the morphological features, the first-order features and the textural features comprise features of capsule walls, partitions and nodules of the lesions; screening the extracted features, and constructing a classification model by using the features with good robustness; and S4, preprocessing and standardizing the image of the current patient, respectively inputting the image into each corresponding automatic segmentation model, and operating the segmentation model and the classification model to realize benign and malignant recognition based on image recognition. According to the invention, integrated and automatic benign and malignant accurate diagnosis of kidney cystic lesions is realized.

The present application relates to a kind of implantable fixation device and method for mouse spinal cord administration, the device includes: catheter assembly, which includes sleeve, injection inner tube and locking nut, the catheter assembly is used to carry out fixed-point infusion in spinal cord parenchyma by the bone hole opened on vertebral vertebra;Vertebra fixation assembly, which includes two V-shaped supports for clamping and fixing on the two sides of the outer periphery of vertebra;And bonding reinforcement system, which includes the initial solid seal layer formed by adhesive to realize the sealing between bone hole and catheter assembly and the structural holding adhesive resin layer formed by resin to realize the fixation between vertebra fixation subassembly and vertebra.The present application designs special vertebra fixation assembly: V-shaped support, and is combined with "biological glue preliminary adhesion" and "dental cement overall wrapping", and constructs a multi-level, rigid-flexible combined "sandwich fixation" composite fixation system.

Bioadhesive and biodegradable polymeric nanoparticles can be administered intrathecally, for example, via the cisterna magna, into the spinal column to allow widespread distribution for the treatment of tumors such as leptomeningeal metastases. The nanoparticles rapidly spread to all cerebrospinal fluid (CSF) compartments, including the brain parenchyma and spinal column. The bioadhesive nanoparticles penetrate and are retained for long periods of time, during which time they can continue to release drugs. These nanoparticles can be loaded with different therapeutic, preventive, or diagnostic agents, most preferably DNA repair inhibitors, to enhance the killing of leptomeningeal tumors, such as leptomeningeal metastases, and disseminated tumors, such as medulloblastoma. In a preferred embodiment, patients are treated with a combination of a PARP inhibitor and temozolomide.

The invention provides a pepper pungency degree rapid detection method based on specific parenchyma cell thickness and application, and belongs to the technical field of pepper quality detection. According to the method, the pungency degree can be rapidly calculated by taking the radial thickness of the specific parenchymal cells on the inner side of the peel of the fresh red chili fruit as a morphological marker, measuring the thickness through sampling, vibration slicing and microscopic observation and substituting the thickness into a linear regression equation y = 25.751 x-3078.4, x is the cell thickness [mu] m, and y is a predicted Scovier index SHU. According to the method, the direct correlation between the pungency degree of the pepper and the cell morphology parameters is established for the first time, and the limitations of high cost, long period and sample damage of a traditional high performance liquid chromatography method are broken through, and the bottleneck of poor model universality of a near-infrared analysis method is broken through. The method has the outstanding advantages of being non-destructive, high in efficiency, low in cost, high in precision and the like, is particularly suitable for large-scale rapid screening of processing type pepper breeding populations, and remarkably accelerates the breeding process.

This invention relates to the field of medical image processing technology, specifically to an automatic detection and classification method and system for intracranial hemorrhage based on three-window CT fusion and label-dependent graph neural network, including the following steps: S100, acquiring the original CT slice image of the head to be detected, performing grayscale mapping on the original slice image based on preset brain window, subdural window and bone window respectively, and stacking the three mapped images along the channel dimension to generate a three-channel fused image; This invention greatly enriches the model's global perception ability of multi-level physiological structures such as brain parenchyma, microhematomas and skull lesions through innovative three-window physical mapping and channel fusion; it introduces a hybrid adjacency matrix graph neural network that combines prior knowledge of neuroradiology with data-driven approach, explicitly establishing pathophysiological causal relationships between various hemorrhage subtypes at the model architecture level, effectively eliminating logical contradictions in predictions that violate clinical common sense.

The invention provides a bamboo fiber bundle and parenchyma tissue separation method, and belongs to the technical field of bamboo wood processing. The method comprises the steps that firstly, bamboo blocks are soaked to be in a saturated state, bamboo slices with the thickness of 45-90 microns are cut out along textures, and the bamboo slices are kept wet; then, the wet sheet is tightly attached to a smooth plane and dried at the normal pressure of 80-120 DEG C or the vacuum temperature of 45-70 DEG C, and cracks capable of being used for separation are generated along the texture of the sheet through constraint shrinkage stress; physically stripping the fiber bundle from the thin-walled structure along the crack; finally, respectively wetting, fixing and slowly drying the fiber bundle sheets and the thin-walled tissue sheets to prepare complete fiber bundle sheets and thin-walled tissue sheets; according to the method, the interface directional cracking is induced through controlled drying, efficient and low-damage separation of the bamboo fiber bundles and the parenchyma tissue is achieved, and the problems that in the prior art, long fiber bundles and large-area parenchyma tissue slices cannot be obtained at the same time, the process is complex, and pollution is large are solved. The method is easy and convenient to operate, environmentally friendly and feasible, and the obtained product is high in integrity and suitable for the fields of spinning, composite materials, micromechanics research and the like.

The invention belongs to the technical field of biological medicine, and discloses a brain targeting peptide-nervonic acid conjugate crossing a blood brain barrier and a preparation method and application thereof.The brain targeting peptide and nervonic acid are covalently coupled, so that the targeting property of nervonic acid is improved, the blood brain barrier crossing capacity of nervonic acid is enhanced, and by increasing the accumulation amount of nervonic acid in brain parenchyma, the brain targeting peptide-nervonic acid conjugate crossing the blood brain barrier is obtained. Precise delivery of nervonic acid is achieved, and the brain-targeted peptide-nervonic acid conjugate can be applied to treatment of brain-related diseases.

The invention discloses a pharmaceutical composition for improving or treating ovarian cancer as well as a preparation method and application of the pharmaceutical composition. The invention provides an engineered cell and a new method capable of remarkably enhancing the migration and infiltration capacity of immune cells to an ovarian cancer parenchyma part and relieving tumor immune escape, so that the defect that the immune cells are difficult to effectively infiltrate to the ovarian cancer parenchyma in the prior art is overcome, and the curative effect of ovarian cancer immunotherapy is remarkably improved.

The invention relates to the field of medicine, and discloses a manufacturing method of a 3D printing liver cancer resection operation guide plate, which comprises the following steps: CT data acquisition: performing liver enhanced scanning to obtain multi-stage DICOM format data; a liver resection range is planned and a surgical section is determined by applying 3D visualization software on the basis of a portal vein 4-level branch drainage basin; 3-matic Medial and other engineering software are applied, and the liver surface and parenchyma inner operation guide plate is designed based on the operation section; a 3D printer is used for printing the digital operation guide plate into a physical model for operation positioning and navigation. Traditional liver cancer operation planning is established on the basis of a standard liver segmentation method and is lack of individuation. At present, the problems of complicated operation, low success rate, poor repeatability and the like exist when a liver pedicle blocking method and a dye injection method are mainly applied to surgical path navigation. The invention relates to a manufacturing method of a 3D printing liver cancer resection operation guide plate. Scientific planning and accurate navigation of an operation are realized through a 3D digital technology. Through the technical method, the radical treatment and safety of an operation are improved, and the liver cancer treatment effect is improved.

Described is a method of repairing the parenchyma of the brain. The method comprises implanting a biodegradable porous polymeric matrix block, such as a piece of collagen matrix, to a void in the brain through a tubular device. A medical device for use in the method is also described.

The present disclosure is directed towards devices, methods, and related systems that are minutely-invasively delivered to the brain parenchyma, subdural or subarachnoid space where the devices, methods, and systems directly interface with central nervous system media (i.e., fluid or tissue) enabling detecting, sensing, measuring, stimulating, altering and / or modulating of the media or tissue surfaces.

The invention discloses a Renal scoring method and device for kidney tumors, and belongs to the field of medical image processing. The method comprises the steps that segmentation data are acquired, and the segmentation data comprise data of kidneys, tumors and blood vessels; anatomical analysis is carried out based on the segmentation data, the kidney principal axis, the renal pelvis position and the ureter are determined, and a natural coordinate system of the kidney is established; calculating the maximum diameter of the tumor based on the tumor voxel, and determining an R score according to the maximum diameter of the tumor; constructing a kidney convex hull based on the kidney parenchyma coordinates, and determining an E score based on the proportion of tumor voxels inside and outside the kidney convex hull; taking the ureter as a set system, determining the minimum distance from the tumor voxel to the set system, and determining an N score according to the minimum distance; constructing a natural interface based on the pelvis position, and determining an A score based on the natural interface; detecting polar lines based on the renal door depression, and determining an L score according to the polar lines. The method provided by the invention eliminates the subjective judgment difference of the scorer.

This invention belongs to the field of medical image processing technology, specifically relating to a kidney segmentation method based on key point localization. The method includes the following steps: acquiring medical images of the kidney to be segmented and preprocessing the images; defining a set of anatomical key points specifically for kidney segmentation; predicting the position coordinates of each key point in the key point set using a model; constructing spatial topological relationships between key points based on the predicted key point coordinates and kidney anatomical zoning rules; and dividing the kidney parenchyma into regions according to the spatial topological relationships and kidney anatomical zoning rules, outputting the segmentation results for each kidney segment. This invention achieves efficient and accurate automatic kidney segmentation by precisely detecting anatomical key points and combining them with the anatomical rules of the Graves kidney segment model, outputting segmentation results with anatomical interpretability, and providing reliable technical support for preoperative planning of urological surgeries such as precise nephrectomy.

The present application belongs to the technical field of dehydrating agent, and particularly relates to a dehydration reagent for biological tissue as well as a preparation method and application thereof. The dehydration reagent comprises a dehydrating agent and an infiltrating agent. The dehydrating agent comprises ethanol, and the infiltrating agent comprises glycerol. Through the synergistic dehydration effect of the ethanol-glycerol mixed solution, the short board of lipid loss caused by single ethanol dehydration is made up. The lipid structure such as cell membrane and cell organ membrane is effectively protected in the dehydration process and is no longer excessively extracted, so that the full form of the cell is maintained, and the volume of the whole brain parenchyma remains stable after dehydration, effectively reducing the volume shrinkage of the biological tissue and maintaining the morphological stability.

The present disclosure discusses a devices, systems and methods for transvascular, transvenous and / or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device / component delivery / insertion / implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.

The present invention provides a strain of Ochrobacterium HRKJ-3, a microbial preparation and an application thereof. The Ochrobacterium HRKJ-3 is deposited with CGMCC No. 24350. The strain was deposited in the General Microbiological Center of China Microbiological Culture Collection Administration on January 20, 2022, and the strain deposited with CGMCC No. 24350. The strain can simultaneously carry out heterotrophic nitrification and aerobic denitrification under aerobic conditions, has good application potential in simplifying the denitrification process, saving processing space and cost, and has good application prospects in the treatment of domestic sewage and the denitrification of livestock and poultry breeding sewage with high ammonia nitrogen concentration.

The invention discloses a stone cell high-purity separation method suitable for a pear fruit development stage, which comprises the following steps: selecting fruit pulp tissues of young pear fruits 30 days after a full-bloom stage, performing freezing grinding treatment, and performing low-temperature pretreatment by using 0.5 mM HCl to destroy pectin connection and weaken intercellular adhesive force; then adding pectinase, carrying out selective enzymolysis under a mild condition, and removing parenchyma cell residues attached to the surfaces of the stone cells; washing with 70% ethanol and acetone to remove cell membranes and pigment components so as to improve the purity of the sample; and finally, enriching the high-density stone cell population by utilizing a Percoll density gradient centrifugation technology to obtain the high-purity stone cells which are complete in structure and free of obvious impurities. The method is easy and convenient to operate and high in repeatability, is particularly suitable for research of the lignification starting and expansion stage of the stone cells in the early development stage, provides a new platform for functional research of the high-lignification structural cells of the plants, and has important scientific research value and application and popularization prospects.

A system for detecting an air leak in the lung parenchyma and / or airway may have a heater configured to vaporize at least one fluid into an aerosol. A conduit system may include a conduit portion configured to be received in a user's airway. A motive flow source is connected to the conduit system for inducing a flow of the aerosol into the conduit portion. A controller is configured for operating the heater to generate the aerosol, and for controlling the motive flow source to induce the flow of the aerosol into the conduit portion at a flow rate of a given level. A method for detecting an air leak in the lung parenchyma and / or airway is also provided.