734 results about "Bone fracture" patented technology

The invention relates to the technical field of model construction, in particular to a method for creating an image recognition model based on clinical disease data integration. The method comprises the following steps: acquiring a medical clinical orthopedic image set; the bone density and the bone form of the medical clinical orthopedic image set are extracted, bone structure division is carried out on the medical clinical orthopedic image set, bone structure division images are generated, and the bone structure division images comprise large bone structure images and small bone structure images; analyzing the bone layer thickness of the big bone structure image and performing physical layer thickness compensation reconstruction on the big bone structure image to generate big bone middle virtual slice data; and performing detail guide reconstruction on the small bone structure image to generate small bone fracture texture reconstruction data. According to the invention, through image resolution enhancement, multi-modal data integration, motion simulation and optimization model training, the accuracy of skeleton image dynamic identification is improved.

The invention relates to the technical field of medical image processing and artificial intelligence, in particular to a multi-part fracture parallel recognition system and method based on a medical image, and the system comprises an image preprocessing module which is used for obtaining an original CT image sequence, carrying out the standardization processing of the original CT image sequence, and outputting a standardized three-dimensional image data body; the basic recognition enhancement module is used for processing the three-dimensional image data body and generating an enhanced feature map; the texture complexity evaluation module is used for processing the three-dimensional image data volume and generating a control signal; the self-adaptive recognition module is used for combining the three-dimensional image data body and the enhanced feature map, responding to the control signal, executing parallel recognition and outputting a parallel recognition result; the diagnosis report generation module is used for summarizing the parallel recognition results and generating a structured fracture diagnosis report, one-time and efficient parallel screening and diagnosis of multi-part fractures are achieved, and the clinical diagnosis efficiency and accuracy are improved.

The invention provides a spine centrum compression fracture recognition method and system based on artificial intelligence, and the method comprises the steps: receiving original spine CT sequence data, and outputting a preprocessed standardized image; inputting the preprocessed image into a three-dimensional U-Net + + network to obtain a centrum segmentation probability graph; outputting the segmented centrum set and the position code thereof; for each segmented centrum, extracting a corresponding area based on a centrum mask, and splicing all features to form a comprehensive feature vector of each centrum; inputting the three-dimensional image block of each vertebral body into an image flow network to extract visual semantic features; and automatically generating a structured PDF report. According to the spine centrum compression fracture recognition method and system based on artificial intelligence, the problem of image quality difference caused by different CT devices and scanning parameters is effectively solved through the multi-scale residual enhancement technology and self-adaptive window level adjustment, and standardized processing of images is achieved.

The invention relates to the field of medical imaging analysis, and discloses a bone trabecula feature construction method and system, and the method comprises the steps: preferentially extracting a fragile region from an obtained vertebral image sequence, and generating an initial feature set representing the stability of a fine-grained structure; performing coherence comparison on the initial feature set in a cross-slice dimension to obtain a composite feature vector capable of reflecting the vulnerability level of the structure; based on the composite feature vector, a connectivity change curve of the bone trabecula in a loading environment is extracted by adopting a multi-layer progressive clustering mode, and candidate bone trabecula units with potential micro-damage trends are marked; classifying the candidate bone trabecula units according to risk gradients, and reconstructing a bone trabecula local topology network with weight levels; and according to the local topology network, identifying high-risk nodes showing an imbalance tendency in a specific mechanical simulation period, and generating a feature construction path finally used for micro-fracture risk prediction. The method has the advantage of improving the micro-fracture risk prediction sensitivity.

Provided herein are devices and methods that represent a dual function approach to tissue engineering and regenerative medicine, particularly for bone fracture or segmental defect healing. The devices include an implantable substrate; a first active composition, and a second active composition that comprises one or more oxygen-modulating compositions. The incorporation of dual bioactive compositions on the substrate offers a versatile platform for manipulating cells and modulating the local tissue oxygen environment at the site of implantation.

The invention belongs to the technical field of biomedical materials and tissue regeneration, and particularly discloses hydrogel with a self-enhanced piezoelectric effect as well as a preparation method and application of the hydrogel. The hydrogel is prepared by taking microphone (MXene), cellulose nanofiber (CNF), tyramine grafted carboxymethyl cellulose (T-CMC) and regenerated silk fibroin (RSF) as main materials through an enzyme crosslinking reaction of horse radish peroxidase (HRP) and hydrogen peroxide (H2O2). The hydrogel has excellent mechanical properties, biocompatibility and safety, and can realize self-enhancement in vivo and generate stable piezoelectric signals. The piezoelectric stimulation can promote proliferation, migration and differentiation of osteogenesis-related cells and regulate and control a bone tissue microenvironment, so that formation and repair of new bones in a bone defect area are remarkably accelerated. The hydrogel can be used as an injectable or moldable bone tissue repair material, and is suitable for bone fracture, bone defect and other bone tissue regeneration scenes.

The invention relates to the technical field of orthopedic biomedical treatment, in particular to a proximal humerus fracture intramedullary bone cement supporting rod. The bone fracture plate comprises a bone fracture plate body, a plurality of first connecting holes and a plurality of second connecting holes are formed in one side of the bone fracture plate body in a penetrating mode, and solid bone nails are arranged in the first connecting holes. According to the device, bone cement is injected into a marrow cavity from an injection molding channel and an injection molding opening and then solidified into a rod body, the marrow cavity space is tightly filled, supporting structures are synchronously formed on the inner side and the outer side of the humerus through cooperation of a bone fracture plate and a bone cement supporting rod in the marrow cavity space, and therefore stress generated when arms of a patient move is evenly dispersed on the two sides of the humerus; the fixing stability is remarkably improved, the risk of internal fixation failure such as steel plate displacement and screw cutting is effectively reduced, and the bone cement supporting rods can further prevent displacement of fracture blocks, promote fracture repair, relieve extrusion and friction of surrounding tissue of a filling position, reduce inflammatory response and postoperative pain and improve the rehabilitation comfort of a patient.

The utility model discloses a bone fracture splint fixing device, and particularly relates to the technical field of medical instruments, the bone fracture splint fixing device comprises a plurality of splint components, the splint components are connected into a ring, each splint component comprises a first splint and a second splint, and a plurality of connecting bands are fixedly connected between the first splint and the second splint. A clamping groove is formed in the first clamping plate, two inserting grooves are formed in the clamping groove, a connecting block is fixedly connected to the side, facing the first clamping plate, of the second clamping plate, and the connecting block is movably inserted into the adjacent inserting grooves. Two fastening belts surround the outer portion of the ring formed by the multiple clamping plate assemblies, the outer portions of the fastening belts are fixedly connected with hook-and-loop fastener loop strips, and the inner sides of the fastening belts are fixedly connected with two hook-and-loop fastener hook face pieces. By adjusting the number of the clamping plate assemblies, the diameter of the formed circular ring can be flexibly adjusted, and therefore personalized adaptation can be carried out according to the body type and the injured part of a wounded person.

The invention relates to the technical field of clinical medicine, and discloses an intertrochanteric fracture postoperative progressive rehabilitation system, which comprises an intertrochanteric fracture comprehensive data acquisition module, a dynamic data monitoring module, a rehabilitation scheme generation module, a rehabilitation execution module, a rehabilitation mode adjustment module, a diet structure adjustment module and a rehabilitation interaction feedback module, the intertrochanteric fracture comprehensive data acquisition module is responsible for acquiring static and semi-dynamic data of a rehabilitation full cycle, the dynamic data monitoring module monitors physiological and motion change data of a patient in daily activities in real time, the rehabilitation scheme generation module generates a personalized stage rehabilitation scheme, and the rehabilitation execution module executes a full-process rehabilitation action. The rehabilitation mode adjusting module is used for adjusting a rehabilitation exercise mode, the diet structure adjusting module is used for optimizing a diet structure, and the rehabilitation interaction feedback module is used for collecting feedback so as to correct the scheme.

A self-contouring plate system for bone fractures comprises a plurality of rigid plate elements connected by ball-and-socket joints. Each plate element includes a ball at one end and a socket at an opposite end for receiving a ball from an adjacent plate element. A single fastener for each plate element serves the dual function of securing the plate to bone and compressing the ball into the socket to lock the joint. The fastener includes bone threads for engaging bone and a head with a lower surface that directly contacts and compresses the ball. The system allows initial flexibility for contouring to complex bone shapes, then locks into position when the fasteners are tightened. The length is adjustable by adding or removing plate elements. Each plate element maintains substantially uniform thickness without protruding elements, and the balls are solid spherical members without through-holes to maximize strength and range of motion.

The invention belongs to the field of biological products, and particularly relates to a bone glue product for preventing and treating osteoporosis and application, the bone glue comprises sheep bone glue (small molecules), pig bone glue (small molecules) and black pig bone glue (small molecules); five animals are beneficial, sheep and pigs are food beneficial to body health, bones are made into bone glue (small molecules) through modern production processes such as an enzyme preparation method and the like, the bone glue (small molecules) is easily dissolved in water and easily absorbed by a human body, can supplement colloid in the bones, is non-toxic and can be eaten for a long time; due to different yin and yang attributes, different types of osteoporosis patients can be prevented and treated; the traditional Chinese medicine also has good prevention and treatment effects on complications, fracture, hairline fracture, arthralgia and other bone diseases caused by osteoporosis; the compound can be applied to preparation of medicines, foods and health-care foods for preventing and treating osteoporosis.

The self-contouring plate system for bone fractures with anti-rotation stop allows a surgeon to bridge a bone fracture, primarily in bones of complex shape where the use of plates or screws is difficult. The self-contouring plate is formed from a series of similar or identical rigid elements, the elements able to bend and rotate with respect to each other. This flexibility is initially helpful as the surgeon contours the device to the shape of the bone. When the desired shape is reached, the elements are locked into place. The length of device is adjusted by adding or removing elements, much like a necklace. Each element of the self-contouring plate includes a ball that extends away from a body, a cavity for receiving the ball of the neighboring plate, and a screw to compress the ball within the cavity.

The invention relates to the technical field of orthopedic surgery, and discloses an orthopedic surgery real-time navigation system based on multi-modal image fusion and artificial intelligence. The multi-modal image fusion module is used for generating a three-dimensional skeleton and soft tissue fusion model for surgical navigation; the artificial intelligence analysis module is used for determining a fracture line, a screw implantation angle and a cutting track; the intraoperative tracking module is used for generating a real-time correction instruction; the verification updating module is used for carrying out rationality verification on the real-time correction instruction; if the inspection is not passed, an alarm mechanism is triggered, instantaneous motion state parameters of the surgical instrument are collected, the instantaneous motion state parameters are compared with the cutting track, and the correction instruction is updated according to the comparison result; and the execution module is used for driving the surgical instrument to execute the surgical operation according to the updating correction instruction. According to the invention, manual operation errors can be effectively reduced.

Disclosed herein are methods of treatment of pain associated with osteoarthritis, pain associated with osteonecrosis, and pain associated with one or more subchondral insufficiency fractures; methods of improving physical function in a human subject with osteoarthritis, osteonecrosis, or one or more subchondral insufficiency fractures; and methods of treating osteoarthritis, or delaying or slowing the progression of osteoarthritis, or relieving a symptom of osteoarthritis, in humans with these diseases, comprising administering a therapeutically effective amount of a composition comprising a glycosylated p75NTR neurotrophin binding protein (NBP)-Fc fusion protein.

The utility model relates to the technical field of surgical instruments, in particular to a locking bone fracture plate which comprises a bone plate body, a plurality of locking holes used for screws to penetrate through are formed in the bone plate body in the length direction, the locking holes are kidney-shaped holes, an inner support and an outer support are arranged in the locking holes and are arranged in a nested mode, and the outer support and the inner support are connected with each other. The outer support can move in the length direction of the locking hole, the inner support can rotate around the width direction of the locking hole, a screw hole is formed in the inner support, a locking groove communicated with the locking hole is formed in the bone plate body, a locking piece abutting against the inner support and the outer support is arranged in the locking groove, and first springs are symmetrically arranged at the two ends of the outer support in the length direction of the outer support. The outer support is arranged in the middle of the locking hole through a first spring. According to the locking bone fracture plate, the angle of the screw hole is adjusted through cooperation of the inner support and the outer support, then the adjusted inner support and the outer support are pre-positioned through the locking piece, the inner support and the outer support are slightly moved through elastic fixing, and self-adaption can be achieved along with bone growth.

The invention relates to the technical field of medical instruments, and discloses an intelligent intervertebral dilator which comprises a transverse center shaft, a plurality of longitudinal shafts perpendicular to the center shaft are clamped on the center shaft side by side, distraction units are slidably connected to the positions, located on the two sides of the center shaft, of the longitudinal shafts respectively, each distraction unit comprises a sliding block, a distraction handle is connected to the lower portion of each sliding block, and the distraction handles are used for being inserted between adjacent vertebral bodies. A driving mechanism is arranged between the sliding block and the longitudinal shaft; the distraction unit located in the middle of the middle shaft is defined as a main distraction device, the other distraction units are defined as auxiliary distraction devices, a pressure sensor and a position sensor are arranged on the main distraction device, and a pressure sensor is arranged on each auxiliary distraction device; the device further comprises a control unit, and the pressure sensor, the position sensor and the driving mechanism are in communication connection with the control unit. The multiple distraction units are arranged to distraction intervertebral spaces synchronously, fracture caused by stress concentration during vertebral body distraction is avoided, pressure borne by the distraction units and the distraction height of the middle of the vertebral body can be monitored in real time, subjective judgment is avoided, and the distraction device is particularly suitable for osteoporosis patients.

The invention discloses an intelligent bone fracture plate integrated with an optical fiber Fabry-Perot sensor and a healing monitoring method. The system comprises an intelligent bone fracture plate module, an in-vitro detection module and a data analysis module. The intelligent bone fracture plate module mainly comprises a bone fracture plate body, a diaphragm type optical fiber Fabry-Perot sensor packaged in a U-shaped groove in the bone fracture plate, and a subcutaneous coupling capsule connected through a leading-out optical fiber. The sensor converts mechanical strain of the bone fracture plate into optical signal change of the Fabry-Perot cavity. The in-vitro detection module is in wireless optical coupling with the subcutaneous coupling capsule through an external read-write equipment head of the in-vitro detection module, probe light is emitted, interference light signals are received and reflected, and the strain of the bone fracture plate is calculated through a spectrum analyzer / detector. And the data analysis module converts the strain data into a key load sharing ratio. By monitoring the trend that the ratio gradually decreases from the postoperation along with time and comparing the trend with a preset clinical threshold value, objective, quantitative, dynamic and non-invasive monitoring of the fracture healing process is achieved.

The auxiliary support comprises a bottom plate, one end in the bottom plate is rotationally connected with a fixed hinge shaft, the two sides of the fixed hinge shaft are hinged to one ends of movable connecting rods respectively, and the other ends of the movable connecting rods are rotationally connected with the two ends of a movable hinge shaft respectively. The middle of the supporting shaft is fixedly connected with a connecting base, one end of the connecting base is fixedly connected with one end of a threaded rod, and the other end of the threaded rod is connected with one end of an inner threaded cylinder in a sleeved mode through a threaded structure. The other end of the internal thread cylinder is rotationally connected with a clamping block, the clamping block is clamped and matched with a clamping groove, and the clamping groove is concavely formed in the middle of the top surface of the bottom plate; sliding openings are formed in the two sides of the bottom plate respectively, adjusting bases are slidably arranged in the sliding openings, one ends of the adjusting bases are hinged to one ends of supporting connecting rods, and the other ends of the supporting connecting rods are hinged to one sides of movable connecting rods respectively.

This application relates to a limiting type internal fixation device for femoral neck fractures, which includes a first fixing plate, a second fixing plate provided on the first fixing plate, positioning screws provided on the first fixing plate, compression screw holes provided on the first fixing plate, and positioning holes provided on the second fixing plate. The second fixing plate is not parallel to the first fixing plate. The positioning screws include a base and a screw body provided on the base. The screw body has telescopic movement in the axial direction and swinging movement in the circumferential direction. The number of positioning screws is two. The limiting type internal fixation device for femoral neck fractures disclosed in this application promotes fracture healing by providing slight sliding in the axial direction and ensures the accuracy of the healing position through micro-displacement and automatic reset in the circumferential direction, so as to avoid excessive shortening of the femoral neck and achieve accurate position healing, thereby obtaining high-quality fracture healing and functional recovery.

The utility model relates to the technical field of medical instruments, and particularly discloses a fracture external fixation splint which comprises a splint body, an external fixation strip and an internal fixation strip. The plate body comprises a fixing plate and a protective pad, the fixing plate is connected with the protective pad through a fastener, one side of the fixing plate away from the protective pad is connected with a retaining ring, an outer fixing strip penetrates through the retaining ring, one side of the retaining ring away from the fixing plate is provided with an inner fixing strip, and the outer fixing strip is connected through a bonding piece A; one ends, close to each other, of the outer fixing strip and the inner fixing strip are connected with first fixing cloth, one ends, close to each other, of the other sides of the outer fixing strip and the inner fixing strip are connected with second fixing cloth, and the first fixing cloth and the second fixing cloth are connected through a bonding piece B; the first fixing cloth and the second fixing cloth are connected through the bonding piece B, the splint can be conveniently fixed to the outer side of the fracture position to play a supporting role, the first fixing cloth and the second fixing cloth are convenient to connect and adjust, use is convenient, and fixation is stable.

The invention relates to the technical field of biology, in particular to application of a GGPS1 activator, a pharmaceutical composition, a kit and a method. The invention relates to bone metabolism regulation and bone regeneration. It is found that improvement of GGPS1 expression / activity can activate TGF-beta / Smad2 / 3 by down-regulating LTBP1, so that human bone marrow mesenchymal stem cells are converted from adipogenesis to osteogenesis, and bone formation and bone defect repair are promoted. The invention provides a drug containing a GGPS1 activator and a controlled release composition for implantation, which are used for osteoporosis, bone mass reduction, delayed fracture healing and the like. The invention also provides an in-vitro screening and evaluation method and a detection kit, and the indexes such as p-Smad2 / 3, alizarin red, oil red O and the like are used for judgment. The invention realizes upstream heavy balance and has the advantages of bone promotion and fat suppression.

The inventors discovered that calcitonin gene-related peptide (CGRP) inhibitors reduce pain caused by bone fracture without impeding healing of the fracture. Accordingly, disclosed herein are methods for treating pain in a subject that has sustained a bone fracture, and the methods comprise administering a therapeutically effective amount of a CGRP inhibitor to the subject.

The application relates to the technical field of big data processing, in particular to a fracture treatment scheme operation scheme simulation system based on big data analysis, which comprises a data preprocessing module, an adversarial network module and a model training and optimization module; a plurality of heterogeneous teacher models are used to pretrain a general large-scale fracture treatment data set, and fracture treatment decision knowledge learned by the plurality of heterogeneous teacher models is transferred to a student model for transfer learning. The application overcomes the contradiction between the small number of comminuted fracture cases (sample sparsity) of a single hospital and the high individualization of medical resources and capabilities (resource difference) by fusing the strategies of generative adversarial network (GAN) sample expansion and heterogeneous teacher model knowledge distillation transfer learning.

The present invention provides pharmaceutical compositions and methods for use in accelerating bone repair and growth and attenuating inflammation-induced osteolysis. In particular, the present invention provides pharmaceutical compositions comprising a peptide comprising the sequence YGFGG for use in treating osteolysis. The present invention further provides pharmaceutical compositions comprising a peptide comprising the sequence YGFGG and CBD for use in accelerating bone repair and / or bone growth in a subject having a bone fracture.

A fixing device for improving fracture stability of an HTO hinge comprises a supporting plate, an attached wing plate, a first locking nail, a second locking nail and a plurality of fixing screws. The wing-attached wing plate is fixed to the supporting plate through a first locking nail, and a second locking nail is driven into the wing-attached wing plate from the rear inner side to the front outer side. The novel fixing device is provided for the outer hinge fracture in the inner side opening wedge-shaped tibia high-position osteotomy, the side wing plate is additionally arranged on the basis of an original supporting plate, the second locking nail which is nailed from the upper portion of the rear inner side to the lower portion of the front outer side is provided for supporting, and therefore the stability of the fracture is improved.

The invention discloses a medical bone fracture plate ultrasonic magnetic ball magneto-rheological composite polishing machine which comprises a polishing groove, a first driving motor for driving the polishing groove to rotate, a polishing disc arranged in the polishing groove and a second driving motor for driving the polishing disc to rotate, a polishing piece is fixed to the bottom of the polishing disc, a permanent magnet is fixed to the polishing disc, and the permanent magnet is fixed to the polishing disc. A plurality of magnetic balls are arranged at the bottom of the polishing groove, magneto-rheological polishing liquid is arranged in the polishing groove, the polishing piece is immersed in the magneto-rheological polishing liquid, and the polishing groove is further connected with an ultrasonic vibrator. The invention further discloses a method for calculating the surface pressure of the polished part. The pressure is calculated through the pressure formed by ultrasonic vibration and the cavitation effect, the hydrodynamic pressure formed on the surface of the workpiece when the magnetorheological polishing fluid flows and the pressure formed on the surface of the workpiece by the gradient magnetic field. The polishing device has the advantage that the polishing efficiency and the polishing effect are remarkably improved.

This invention provides a wire traction assembly for treating phalanx avulsion fractures, relating to the field of biomedical engineering technology. The wire traction assembly for treating phalanx avulsion fractures includes: a sleeve having a first end, a bent portion, and a second end; an insertion hole on the first end and a threading hole on the second end; a Kirschner wire for insertion into the insertion hole; and a tension band wire for attachment to the threading hole. This application achieves reliable wire fixation through direct attachment of the tension band wire to the threading hole, rather than by hanging it on the bent end of the Kirschner wire as in traditional techniques. Because the threading hole is a completely closed structure, the tension band wire cannot slip out of the hole under stress, effectively avoiding the risk of the wire slipping off at the smooth end of the needle in traditional techniques.

The utility model discloses an in-vitro sighting device for femoral trochanter fracture, and relates to the technical field of fracture surgical instruments. Comprising a matching frame, an extension structure, a guide cylinder and a developing needle, the matching frame is U-shaped, the corner of the matching frame is of a right-angle structure, the opening of the matching frame is placed towards one of two sides, a matching hole is formed in a middle plate between two side plates of the matching frame, the extension structure is arranged on the upper side of the matching frame, and the guide cylinder is arranged on the extension structure. The extending structure extends in the direction away from the matching frame, a guide cylinder is arranged on the extending structure and is arranged in the opening direction of the matching frame, a sliding hole is formed in the central axis of the guide cylinder, and a developing needle is slidably connected into the sliding hole of the guide cylinder; through cooperation of the matching frame and the sighting device and the height of the extension structure, the developing needle in the guide cylinder is higher than the front side of the thigh and corresponds to the position of the guide needle to be placed through the sighting device, the position of the guide needle is prompted in a perspective mode, and damage to a patient caused by wrong position and repeated placement of the guide needle is avoided.

The application discloses a kind of elderly hip fracture surgery perioperative adverse event real-time monitoring system and method, it is related to perioperative monitoring technical field.The method includes: real-time acquisition perioperative monitoring data, carries out data pre-processing, and extracts benchmark feature;Identify the decline segment of cerebral oxygen saturation below benchmark feature, jointly assess the decline amplitude and persistence, obtain the weak trend characterization of brain oxygen;Analysis of the relative change characteristics of serum inflammatory markers, form the weak trend characterization of inflammation;Assess the deviation degree of vital signs relative to benchmark, obtain the vital signs fluctuation characterization, and further judge the delirium precursor risk, output risk prompt;Visual display various weak trend characterizations and delirium precursor risk, link label risk trigger information and contribution source.The present application solves the technical problems that the prior art is difficult to extract and identify early weak abnormal trend in perioperative multi-source physiological signals.

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.