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450 results about "Bone cement" patented technology

Bone cements have been used very successfully to anchor artificial joints (hip joints, knee joints, shoulder and elbow joints) for more than half a century. Artificial joints (referred to as prostheses) are anchored with bone cement. The bone cement fills the free space between the prosthesis and the bone and plays the important role of an elastic zone. This is necessary because the human hip is acted on by approximately 10-12 times the body weight and therefore the bone cement must absorb the forces acting on the hips to ensure that the artificial implant remains in place over the long term.

Bone cement for orthopedic repair and preparation method thereof

The invention discloses bone cement for orthopedic repair and a preparation method thereof, and relates to the technical field of bone cement. The bone cement for orthopedic repair comprises solid-phase powder and a liquid-phase component, the solid-phase powder comprises the following components in parts by weight: 55-65 parts of composite calcium phosphate, 10-15 parts of bioactive glass, 2-3 parts of a developing agent, 1-2 parts of hydroxyapatite, 8-12 parts of a modified toughening agent and 2-3 parts of nano cellulose fibers; the liquid phase component is prepared from the following components in parts by weight: 40 to 50 parts of a sodium alginate solution, 10 to 20 parts of methacrylated gelatin, 0.5 to 1 part of transglutaminase, 30 to 60 parts of a citric acid buffer solution and 1 to 2 parts of an antibacterial agent. The preparation method comprises the following steps: reacting pentaerythritol with 12-oxododecanoic acid to obtain an intermediate 1, and reacting the intermediate 1 with dopamine to prepare the modified toughening agent. The bone cement for orthopedic repair prepared by the invention has good mechanical, self-repairing and antibacterial properties.
Owner:HUBEI SHUANGXING PHARMA CO LTD

High-bending-resistance injectable magnesium phosphate bone cement and preparation method thereof

The invention provides high-bending-resistance injectable magnesium phosphate bone cement. The high-bending-resistance injectable magnesium phosphate bone cement is prepared from solid-phase powder, reinforcing filler and water, the solid-phase powder comprises the following components in parts by weight: 50-70 parts of magnesium phosphate salt and 30-50 parts of hydrogen phosphate, and the magnesium phosphate salt comprises trimagnesium phosphate; the reinforcing filler comprises a polyurethane modified epoxy resin emulsion; based on the polyurethane modified epoxy resin emulsion with the solid content of 30%-50%, the mass fractions of the solid phase powder, the reinforcing filler and the water in the bone cement are 66-70 wt%, 1-7 wt% and 23-33 wt% respectively. The high-bending-resistance injectable magnesium phosphate bone cement is high in bending strength and suitable for bone defect areas bearing multidirectional loads.
Owner:WUHAN UNIV OF TECH

Bone cement injection device for skull repair

The invention relates to a bone cement injection device for skull repair. The bone cement injection device comprises an outer sheath tube, a separate injection structure and an outer push rod, a pushing channel extending in the axial direction is formed in the outer sheath tube, the tube wall of the outer sheath tube is provided with a first hole group and a second hole group which are symmetrically distributed by 180 degrees in the circumferential direction, and each hole group comprises a plurality of via holes arranged at equal intervals in the axial direction; the two symmetrically-arranged separated injection structures are arranged corresponding to the first hole set and the second hole set respectively, each separated injection structure comprises a separated injection pipe, the separated injection pipe is inserted into the pushing channel, a perfusion channel extending in the axial direction is arranged in the separated injection pipe, the near end of the perfusion channel is through, and the far end of the perfusion channel is closed; the rigid contact pins are arranged at equal intervals in the axial direction of the separate injection pipe and penetrate through the side wall of the separate injection pipe at the same circumferential angle, and the inner end of each contact pin is communicated with the perfusion channel. The repairing block can be effectively filled with bone cement, and the effect after skull repairing is improved.
Owner:XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI

Treatment device and screw

ActiveUS12484938B2Internal osteosythesisFastenersVertebroplasty procedureVertebral pedicle
This invention relates to a treatment device suitable for combined operative procedure of vertebroplasty and pediculoplasty. A treatment device includes a cylindrical driver capable of driving a screw into bone, an inner sleeve capable of being inserted into the driver, and a guide pin capable of being inserted into the inner sleeve, and is configured as follows. The screw includes on an outer wall (outer circumference) a thread that can tap into bone or cement, and a through hole that allows the inner sleeve to pass from a head to a tip. The driver can fit onto the head of the screw and when moved along the central axis and be joined to the screw, so as to transmit torque about the central axis to the screw. The inner sleeve includes a notch which protrudes, when the inner sleeve is inserted from the distal end of the driver in a state in which the screw and the driver are joined together, protrudes more proximally than a tip of the screw, preventing removal of the screw.
Owner:SPINE CHRONICLE JAPAN CO LTD

Nail feeding device

The invention discloses a screw feeding device which is suitable for a pedicle screw. The screw feeding device comprises an implanting mechanism and a torque applying mechanism which are in transmission connection with a pedicle screw; the torque applying mechanism is configured to be in an engaged state and a disengaged state with the implanting mechanism; when the torque applying mechanism and the implantation mechanism are in a joint state, the torque applying mechanism can transmit torque to the implantation mechanism; and when the torque applying mechanism and the implanting mechanism are in a separated state, the torque applying mechanism is separated from the implanting mechanism, so that the torque is prevented from acting on the implanting mechanism in the exiting process of the torque applying mechanism, and the pedicle screw is prevented from loosening. According to the vertebral pedicle screw, the operation time can be shortened, the operation steps can be simplified, the cooperation among instruments can be optimized, the complex operation of a surgeon on the cooperation of the instruments can be reduced, the vertebral pedicle screw cannot be loosened, and bone cement can be rapidly placed at the same time, so that the possibility of bone cement leakage and embolism can be reduced.
Owner:NINGBO HICREN BIOTECHNOLOGY CO LTD

Intramedullary bone cement supporting rod for proximal humerus fracture

The invention relates to the technical field of orthopedic biomedical treatment, in particular to a proximal humerus fracture intramedullary bone cement supporting rod. The bone fracture plate comprises a bone fracture plate body, a plurality of first connecting holes and a plurality of second connecting holes are formed in one side of the bone fracture plate body in a penetrating mode, and solid bone nails are arranged in the first connecting holes. According to the device, bone cement is injected into a marrow cavity from an injection molding channel and an injection molding opening and then solidified into a rod body, the marrow cavity space is tightly filled, supporting structures are synchronously formed on the inner side and the outer side of the humerus through cooperation of a bone fracture plate and a bone cement supporting rod in the marrow cavity space, and therefore stress generated when arms of a patient move is evenly dispersed on the two sides of the humerus; the fixing stability is remarkably improved, the risk of internal fixation failure such as steel plate displacement and screw cutting is effectively reduced, and the bone cement supporting rods can further prevent displacement of fracture blocks, promote fracture repair, relieve extrusion and friction of surrounding tissue of a filling position, reduce inflammatory response and postoperative pain and improve the rehabilitation comfort of a patient.
Owner:TONGLIAO HOSPITAL

Biological tissue adhesive composition

The invention relates to the technical field of biological tissue adhesives, in particular to a biological tissue adhesive composition. The biological tissue adhesive composition comprises a powder A, a powder B and a powder C, wherein the powder A is obtained by curing calcium silicate and acidic calcium phosphate in a curing liquid, curing, drying and crushing; powder B: bivalent metal salt; powder C: phosphorylated amino acid; and an aqueous solvent; the biological tissue adhesive is used for bone adhesion and bone repair. According to the biological tissue adhesive composition provided by the invention, a silicate / hydroxyapatite composite material with a bone induction function is synthesized through optimized bone cement reaction, a curing liquid is added to react with phosphorylated amino acid, and a bone adhesive material is obtained through organic and inorganic material coordination reaction; the bone repairing and regenerating capability and the bone bonding capability are good.
Owner:HANGZHOU HUIRUISEN BIOTECHNOLOGY CO LTD

Bone cement mixing system with puncture connection

A device for producing bone cement, comprising a base part which has a container for receiving a monomer liquid, a bottom part with a collection region, and a hollow mandrel with a tip, and a cartridge for receiving a PMMA bone cement powder, wherein the cartridge has a septum which delimits the cartridge toward the outside, wherein the device is designed and configured to form a fluid-conducting connection between the base part and the cartridge by the hollow mandrel piercing the septum so as to transfer a monomer liquid from the collection region into the cartridge.
Owner:HERAEUS MEDICAL GMBH

Bone cement composition and application thereof

The invention discloses a bone cement composition and application thereof, and relates to the technical field of bone cement. The bone cement composition comprises a solid phase component and a liquid phase component, wherein the solid phase component comprises 60-75 parts of composite calcium phosphate, 10-20 parts of strontium glass powder, 8-12 parts of a reinforcing agent and 3-7 parts of a solidification reaction regulator; the liquid phase component comprises 20-30 parts of a phosphate buffer solution, 3-8 parts of a sodium citrate solution, 5-15 parts of an anti-inflammatory agent and 1-5 parts of a hyaluronic acid solution. The preparation method comprises the following steps: reacting 1, 10-phenanthrene-2, 9-dicarboxylic acid with 2-aminomethyl furan to obtain an intermediate 1, and reacting the intermediate 1 with poly (ethylene glycol) maleimide to prepare the reinforcing agent. The prepared bone cement composition has good mechanical properties, self-repairing performance and anti-inflammatory performance, and has a good application prospect in the field of bone repairing.
Owner:HUBEI SHUANGXING PHARMA CO LTD

Pelvic brittle fracture bionic hollow screw manufactured based on 3D printing technology

The utility model discloses a pelvic brittle fracture bionic hollow screw manufactured based on the 3D printing technology. The pelvic brittle fracture bionic hollow screw manufactured based on the 3D printing technology comprises a screw body, and the screw body comprises a screw tail, a supporting part and a screw head; a thread, a diversion trench and a microporous structure are arranged on the supporting part; the micropore structure comprises a plurality of point position sets spirally arranged on the supporting part, and the difference between every two adjacent point position sets is one fourth of the circumference. According to the pelvic brittle fracture bionic hollow screw manufactured based on the 3D printing technology, the screw body manufactured through the D printing technology is arranged, a micro-pore structure distributed in a topological configuration mode can be conveniently arranged on the screw body, bone cement can be conveniently spread around the screw body in a more dispersed mode through the micro-pore structure, and therefore the bone cement can be more evenly distributed on the periphery of the screw body. And the micropore structure is beneficial to bone tissue growth, so that the long-term stability of the screw is improved.
Owner:XIAN HONGHUI HOSPITAL

Composite intramedullary fixing bone end broach system for extramedullary 3D printing

The invention provides an extramedullary 3D printing composite intramedullary fixing bone end broach system, and relates to the technical field of medical instruments. Comprising a bone prosthesis and a fixing system, and the fixing system comprises a broach which is arranged at one end of the bone prosthesis and is fixed in a medullary cavity through bone cement; the fixing piece is arranged at the end, close to the broach, of the bone prosthesis and makes contact with the host bone, and the contact face is a 3D printing interface; the preset part is used for replacing the fixing part to make contact with the host bone in the prosthesis mounting operation. According to the fixing system, the broach, the fixing part and the preset part are used in cooperation, bone cement in a medullary cavity is fixed through the broach, and 3D interface fixing is adopted through the fixing part, so that the bone prosthesis has good bone conductivity and mechanical stability in a long term and a short term; and the influence on bone ingrowth caused by the fact that bone cement falls into a 3D contact interface of the fixing piece in a prosthesis installation operation is avoided.
Owner:THE FIRST AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV

Femoral stem prosthesis

The invention provides a femoral stem prosthesis. The femoral stem prosthesis comprises a femoral stem, an expansion component and a sleeve. The femoral stem is composed of an upper stem body and a replaceable lower stem body, and threads are arranged in the femoral stem. The expansion part is located in the upper handle body and comprises a screw, a rotating disc and a multi-layer pushing structure. The screws are connected with the upper and lower handle bodies through threads; and the turntable is in threaded engagement with the screw and can drive the first pushing part along the first guide rail during rotation. Ratchets are arranged in the rail component and meshed with the pawls of the second pushing part, and an open hole is formed in the side of the second pushing part. And the sleeve is linked with the expansion component through the fifth pushing part, the fourth pushing part and the third pushing part. During implantation, the second pushing part outwards pushes the sleeve to be attached to the wall of the medullary cavity, the internal pushing structure acts successively under the counter-acting force, and finally the first pushing part is separated from the second pushing part. Then bone cement is injected through a sleeve micropore, and the stability of the prosthesis is enhanced. By means of the design, intraoperative adaptation and stable filling are achieved.
Owner:BEIJING AKEC MEDICAL +1

Copper selenide / tricalcium silicate bone cement

The invention discloses copper selenide / tricalcium silicate bone cement. The bone cement comprises a liquid phase component and a solid phase component, the liquid phase component is water, and the solid phase component is tricalcium silicate powder and copper selenide nanoparticles. Compared with the existing tricalcium silicate bone cement, the tricalcium silicate bone cement has the advantages that by introducing a trace amount of copper selenide nanoparticles, not only can the hydration and coagulation time of tricalcium silicate be shortened, but also the porosity and degradation rate of the tricalcium silicate after coagulation and solidification can be reduced, the compressive strength can be improved, the stimulation effect on ALP activity of MC3T3-E1 cells can be enhanced, the survival rate of the MC3T3-E1 cells can be improved, and the application prospect is broad. The immunogenic apoptosis of K7M2-wt cells is promoted, and the tumor growth rate is reduced. Besides, the introduction of the copper selenide nanoparticles can also endow the tricalcium silicate bone cement with the performance of temperature rise under near-infrared light, so that in clinical application, the tricalcium silicate bone cement can be further combined with a near-infrared technology to realize ablation of bone tumors, and a new strategy is provided for treatment of the bone tumors.
Owner:THE 940TH HOSPITAL OF THE CHINESE PEOPLES LIBERATION ARMY JOINT LOGISTICS SUPPORT FORCE

Preparation process of novel composite bone cement with biological activity

The invention relates to the technical field of biomedical materials, in particular to a preparation process of novel composite bone cement with biological activity, which comprises the following steps: calcining calcium phosphate in a calcining furnace at 800-1000 DEG C for 3 hours, cooling to 20 DEG C, grinding the calcium phosphate by using a grinding machine until the diameter is less than 100 mu m, and drying to obtain the novel composite bone cement with biological activity. Calcium phosphate micro powder is obtained; by fusing the calcium phosphate, the nano-hydroxyapatite, the bioglass and the collagen, the material has a mechanical support function of an inorganic phase and biological activity of an organic phase, the nano-hydroxyapatite is extremely similar to human bone minerals and can promote osteoblast attachment and growth, and the collagen constructs a bionic microenvironment and accelerates new bone formation, so that the material can be used for treating osteoporosis. The bone repair efficiency is obviously improved.
Owner:SHANDONG KANGSHENG MEDICAL EQUIP CO LTD

Gradient pore-forming magnesium-containing calcium phosphate bone repair material and preparation method thereof

The invention discloses a preparation method of a gradient pore-forming magnesium-containing calcium phosphate bone repair material, which comprises the following steps: S1, mixing nano-hydroxyapatite with polylactic acid-glycolic acid copolymer (PLGA) powder, adding dichloromethane as a solvent, continuously stirring to form a solution, and freeze-drying to obtain an nHA / PLGA raw material, and carrying out high-temperature fused deposition through a 3D biological printer to prepare the degradable nPLGA stent. S2, weighing the calcium phosphate bone cement powder and the magnesium metal microspheres according to a preset mass ratio, stirring the slurry and homogenizing to obtain calcium phosphate bone cement slurry containing the magnesium metal microspheres; s3, injecting the calcium phosphate bone cement slurry obtained in the step S2 into the nPLGA stent prepared in the step S1 to obtain an MC / nPLGA compound; gradient micropores are generated through hydration reaction of the magnesium microspheres, the gradient micropores and macropores formed by degradation of PLGA form a complementary structure, and the total porosity reaches 68% and is increased by 3.4 times compared with traditional CPC.
Owner:GUANGXI MEDICAL UNIVERSITY

Therapeutic instrument

PCT designated stageWO2025169259A1Surgical needlesBone drill guidesSkin incisionBone cement
The present invention provides a therapeutic instrument including a vertebral drilling guide and a bone drilling instrument, the therapeutic instrument being configured as follows. The vertebral drilling guide is a hollow cylindrical shape along a central axis, with a first scoop part opening in a direction perpendicular to the central axis at the leading-end side along the central axis and a second scoop part opening in the opposite direction of the perpendicular direction at the base-end side along the central axis. The bone drilling instrument is rod-shaped, is smoothly curved in the perpendicular direction along a central axis, and when inserted into the vertebral drilling guide along the central axis from the distal end of the second scoop part of the vertebral drilling guide, a leading-end portion thereof protrudes out of an opening in the first scoop part. This makes it possible to provide a safe therapeutic instrument that enables precise drilling of an intended area all the way inside the vertebral body while minimizing skin incision in percutaneous vertebroplasty of fractures and prophylactic reinforcement of the vertebral body with bone cement.
Owner:SPINE CHRONICLE JAPAN CO LTD

Patient-specific finite element model-based vertebroplasty optimization method and related device

The invention discloses a patient-specific finite element model-based vertebroplasty optimization method and a related device. The method comprises the following steps of: constructing a patient-specific three-dimensional spine model according to a vertebral bone structure and a vertebral soft tissue structure; discretizing the patient-specific three-dimensional spine model into tetrahedral finite element grids, endowing each finite element unit with bone material attributes according to pixel values of CT scanning images, and endowing intervertebral disc and ligament soft tissue structures with soft tissue material attributes; determining an optimal bone cement injection path and an optimal bone cement injection amount of the tetrahedral finite element mesh; and simulating the vertebroplasty in the tetrahedral finite element mesh, predicting the stress distribution of the vertebrae, the rigidity of the vertebrae and the stress change of the adjacent vertebrae after the operation, and presenting the simulation result of the simulated vertebroplasty in a three-dimensional visual form. According to the method, personalized optimization and prediction of preoperative simulation of the vertebroplasty are realized by constructing the patient-specific finite element model, and an efficient auxiliary reference operation scheme is provided for an operator.
Owner:HECHI FIRST PEOPLES HOSPITAL

Bone cement monomer equalizer with small structure

The utility model discloses a bone cement monomer equalizer with a small structure, which comprises a shell, an equalizer arranged in the shell, a piston sleeve movably arranged in the equalizer, a liquid outlet hole formed in the center of the bottom of the piston sleeve, and a rubber plug movably clamped in the liquid outlet hole, a breaking and filtering assembly which is provided with an ampoule bottle and is not communicated with the external environment is vertically arranged in the piston sleeve in a communicating mode, four liquid collecting pipes are evenly distributed on the bottom wall of the equalizer, the four liquid collecting pipes are all communicated with the equalizer, pistons are movably arranged in the liquid collecting pipes in a sealed mode, drainage pipes are arranged in the pistons, and the drainage pipes are communicated with the liquid collecting pipes. The drainage tube penetrates through the liquid collecting tube and the shell and then extends outwards, a one-way Luer taper is arranged on the drainage tube, and the flow direction of the one-way Luer taper is from the outside to the drainage tube. The utility model has the advantages that the structure is small and exquisite, the production can be reduced, and the production and the use are convenient.
Owner:JIANGSU LEKAI BIOTECHNOLOGY CO LTD

Bone screw inserters and methods

Bone screw drivers are disclosed that apply torque to a threaded shank of a bone screw assembly and receive a cement delivery device to introduce bone cement through the threaded shank. Also disclosed are driver adapters that couple to a driver in order to facilitate application of torque thereto. The driver adapter can decouple from the driver after implanting a bone screw shank to allow the subsequent use of a cement delivery device in combination with the driver. The devices can be reusable and can employ a number of additional components, including retaining and counter-torque sleeves, driving handles, etc. Further, the devices can allow setup of a bone screw inserter assembly outside a surgical field, such that a completed assembly can be passed to a surgeon or other user for immediate use.
Owner:MEDOS INT SARL

Bone cement monomer dispenser (free quantitative)

ActiveCN309457483SPolymer scienceBone cement
1. The name of this design product: Bone cement monomer dispenser (free quantitative). 2. Purpose of this product design: used for high-precision packaging of bone cement monomers. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.
Owner:JIANGSU LEKAI BIOTECHNOLOGY CO LTD

High-stability durable tibial prosthesis

The utility model relates to the technical field of medical instruments, and discloses a high-stability durable tibial prosthesis which comprises a locking mechanism, the locking mechanism is of a double-layer structure, an anti-rotation mechanism is rotatably arranged on the lower end face of the locking mechanism, a telescopic mechanism is movably arranged on the lower end face of the anti-rotation mechanism, and an implanting mechanism is fixedly arranged on the lower end face of the telescopic mechanism. The locking mechanism comprises a locking hole, a side wing steel plate, a tibial plateau, a bone trabecula porous structure, a locking bone screw, a first suture hole and a second suture hole, the anti-rotation mechanism comprises an anti-rotation block, an anti-rotation groove, a first cylindrical pin and an anti-rotation rod, and the telescopic mechanism comprises a telescopic handle, a second through hole, a second cylindrical pin, an adjusting button and an adjusting shaft. The implanting mechanism comprises an intramedullary nail and a bone cement groove. According to the bone trabecula prosthesis, the retraction mechanism is arranged and can be adjusted according to the requirements of different patients, and the bone trabecula porous structure and the anti-rotation mechanism are arranged, so that the prosthesis can be kept stable.
Owner:TANGSHAN SECOND HOSPITAL

Carbon fiber bone fracture plate device

The invention discloses a carbon fiber bone fracture plate device which comprises a bone fracture plate body made of thermoplastic resin / carbon fiber composite materials, the bone fracture plate body is composed of at least two plates, at least one pair of adjacent plates form a binding face structure, two bone cement containing cavities are arranged at the same time, and when the bone fracture plate device is used or needs to be molded, the binding face structure is made of thermoplastic resin / carbon fiber composite materials. According to the specific angle of the bone, the two adjacent plates rotate along the attaching face to conduct angle adjustment, after adjustment is completed, the clamping device is used for clamping, the first face and the second face are kept to be attached, the two bone cement containing cavities are at least partially in butt joint, namely, the two bone cement containing cavities are communicated, at the moment, bone cement is injected into the two bone cement containing cavities through the injection channel, and the bone cement is injected into the bone cement containing cavities. And after the bone cement is solidified, the bone fracture plate main body becomes a whole, molding is completed, and the problem that an existing bone fracture plate formed by the thermoplastic resin / carbon fiber composite material cannot be molded during use is solved.
Owner:JIANGSU BAIDE MEDICAL INSTR CO LTD

Bone insert augment and offset device

A bone insert includes a cap having a convex top surface, an elongated stem, and a barrier between the cap and the stem. The stem of the bone insert is inserted into a hole formed in a host bone until the barrier is pressed against the exposed bone. The bone implant can be placed against a small focus contact point on the cap. Liquid cement can be injected into a space volume between the host bone and a bone implant. The cap can be made of a material and / or have surface features that create a strong bond with the cement when the liquid cement cures. The stem can be made of a material and / or have bone ingrowth surface features that create a strong bond with the bone.
Owner:TAQ ORTHO LLC

A mold for manufacturing a shoulder joint spacer and a method of manufacturing the same

ActiveCN121221329BUniform applicationGuaranteed support strengthJoint implantsShoulder jointsShoulder joint capsuleSilica gel
The application discloses a mold for manufacturing a shoulder joint spacer and a preparation method thereof, belongs to the technical field of shoulder joint spacer preparation, and solves the problems of uneven distribution of medicine application grooves and the inability to flexibly adjust the size, length and the like according to requirements, and comprises a lower mold box, an upper mold box, an intramedullary bone cement silica gel forming adjusting mold and a ball head forming adjusting mold which are sleeved in the lower mold box and the upper mold box, a pouring gate which is arranged on the lower mold box and the upper mold box, a plugging plug which is arranged in the pouring gate, a first positioning support column and a second positioning support column which are arranged in the lower mold box, a third positioning support column and a fourth positioning support column which are arranged in the upper mold box, and a metal support rod which is arranged on the axial center lines of the intramedullary bone cement silica gel forming adjusting mold and the ball head forming adjusting mold; and the intramedullary bone cement silica gel forming adjusting mold and the ball head forming adjusting mold are uniformly provided with protruding portions.
Owner:SICHUAN HESHUN MEDITECH CO LTD +2

Orthopedic repair bone cement and method of making same

The application discloses a bone cement for orthopedic repair and a preparation method thereof, and relates to the technical field of bone cement.The bone cement for orthopedic repair comprises solid-phase powder and liquid-phase components; the solid-phase powder comprises the following components in parts by weight: 55-65 parts of composite calcium phosphate salt, 10-15 parts of bioactive glass, 2-3 parts of developing agent, 1-2 parts of hydroxyapatite, 8-12 parts of modified toughening agent and 2-3 parts of nanocellulose fiber; and the liquid-phase components comprise the following components in parts by weight: 40-50 parts of sodium alginate solution, 10-20 parts of methacrylated gelatin, 0.5-1 part of transglutaminase, 30-60 parts of citric acid buffer and 1-2 parts of antibacterial agent. The intermediate 1 is obtained by the reaction of pentaerythritol and 12-oxododecanoic acid, and the modified toughening agent is prepared by the reaction of the intermediate 1 and dopamine. The bone cement for orthopedic repair prepared by the application has good mechanical properties, self-repairing performance and antibacterial performance.
Owner:HUBEI SHUANGXING PHARMA CO LTD

Preparation method of photo-thermal response type gold nanorod-bone cement composite material

The invention relates to the technical field of preparation of bone cement, and particularly discloses a preparation method of a photo-thermal response type gold nanorod-bone cement composite material. The method comprises the following steps: synthesizing a gold seed solution; constructing a growth solution; controlling the growth of the nanorod; gradient centrifugal purification; carrying out surface ligand exchange (sulfydryl-PEG); preparing a bone cement composite material; curing and forming; gold nanorods (GNRs) are uniformly embedded into a polymethyl methacrylate (PMMA) bone cement matrix, so that the problems that free nanorods are easy to migrate and poor in bone targeting are solved. The local temperature can be accurately controlled, and damage to surrounding tissues is avoided. According to the invention, immunogen cell death (ICD) can be effectively induced, and anti-tumor immune response can be activated. According to the invention, enough mechanical support can be provided, and the stability after implantation is ensured.
Owner:THE 960TH HOSPITAL OF THE CHINESE PEOPLES LIBERATION ARMY JOINT LOGISTICS SUPPORT FORCE

Preparation method and application of a core-shell composite flexible biomaterial

PendingCN122297794ATissue repairCD31
This invention discloses a method for preparing and applying a shell-core composite flexible biomaterial. The flexible biomaterial consists of an outer PMMA electrospun layer, a middle PTFF or PE layer, and a core PEG hydrogel; both the PMMA electrospun layer and the middle layer are porous. This flexible material is soft and elastic, exhibiting good film-forming and osteogenic induction effects. Animal experiments have confirmed that, compared to traditional bone cement, the flexible composite bone cement-induced biofilm shows an increase in CD31-positive cells (representing angiogenesis) and M2 macrophages (representing tissue repair), exhibiting better film-forming properties. It is a promising composite biomaterial that can be widely applied in the treatment of soft tissue defects, bone defects, and bone infections, achieving better therapeutic effects.
Owner:XIANGYANG CENT HOSPITAL

Bone cement dispersion state prediction method

The invention belongs to the technical field of bone cement dispersion prediction, and discloses a bone cement dispersion state prediction method, which comprises the following steps: S1, acquiring voxel points of a preoperative vertebra image as modeling data to train network parameters of a first convolutional neural network; s2, calculating a first velocity field and a first pressure field of flowing of the bone cement to obtain first training output data and second training output data; s3, calculating a directed distance function value of the flow area grid and outputting an area mark to obtain first training input data and second training input data; s4, training to obtain network parameters of a second convolutional neural network; s5, calculating a target velocity field and a target pressure field of the flowing of the current bone cement to be injected; and S6, calculating the motion track of the current to-be-injected bone cement to obtain the dispersion state of the current to-be-injected bone cement. The bone cement dispersion state prediction accuracy is high, and reliable reference can be provided for bone cement injection in a clinical operation.
Owner:NORTHERN JIANGSU PEOPLES HOSPITAL

Safety mechanism for ultrasonically vibrating surgical tools

An ultrasonically vibrating surgical tool for removing cement (7) in artificial joint revision surgery has an ultrasonic vibration source operationally coupled to a working tip (5) that acts on the cement (7) in the lumen (8) of a bone such as a femur (1). When acting on the cement (7), the tool vibrates at substantially a single resonant frequency. If the working tip (5) comes into contact with a hard material such as the bone wall (6) of the femur (1), additional supplemental vibrations are generated at other frequencies. The tool is equipped with a microphone or other vibration detector to pick up these supplemental vibrations, which may be in the audible or ultrasonic range. If supplemental vibrations are detected at a frequency characteristic of contact between the working tip (5) and bone, the user of the tool is warned and the operation of the tool is interrupted.
Owner:RADLEY SCI LTD

Preparation method of a hip joint bone cement placeholder

Disclosed are a metal inner core, a placeholder and a preparation method for a hip joint bone cement placeholder. By designing the metal inner core including a frame body and a supporting portion inside the hip joint bone cement placeholder, the strength of the placeholder is enhanced; due to the fact that the metal inner core is hollow, the antibiotic bone cement can fill the inner portion of the metal inner core, the content of antibiotics in the placeholder cannot be affected, and infection is effectively controlled; the hollowed-out structure endows the placeholder with lighter weight and stronger structural strength, and meanwhile, the material cost is effectively reduced; and according to the preparation method of the hip joint bone cement placeholder, the size design of the placeholder and the metal inner core is carried out, so that the joint matching degree between the placeholder and the patient is high.
Owner:THE THIRD AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY (GUANGZHOU SEVERE MATERNAL TREATMENT CENTER GUANGZHOU ROUJI HOSPITAL)