593 results about "Bone cement" patented technology

The invention discloses bone cement for orthopedic repair and a preparation method thereof, and relates to the technical field of bone cement. The bone cement for orthopedic repair comprises solid-phase powder and a liquid-phase component, the solid-phase powder comprises the following components in parts by weight: 55-65 parts of composite calcium phosphate, 10-15 parts of bioactive glass, 2-3 parts of a developing agent, 1-2 parts of hydroxyapatite, 8-12 parts of a modified toughening agent and 2-3 parts of nano cellulose fibers; the liquid phase component is prepared from the following components in parts by weight: 40 to 50 parts of a sodium alginate solution, 10 to 20 parts of methacrylated gelatin, 0.5 to 1 part of transglutaminase, 30 to 60 parts of a citric acid buffer solution and 1 to 2 parts of an antibacterial agent. The preparation method comprises the following steps: reacting pentaerythritol with 12-oxododecanoic acid to obtain an intermediate 1, and reacting the intermediate 1 with dopamine to prepare the modified toughening agent. The bone cement for orthopedic repair prepared by the invention has good mechanical, self-repairing and antibacterial properties.

The invention provides a bone cement injection anti-leakage planning method, system and device for spine centrum compression fracture and a computer readable storage medium. The bone cement injection anti-leakage planning method for the spine centrum compression fracture comprises the steps that a spine CT image of a patient is acquired; performing identification and segmentation based on the spine CT image to obtain a fracture centrum CT image of the spine centrum compression fracture part; carrying out three-dimensional reconstruction on the fracture centrum CT image to obtain a fracture centrum three-dimensional model; inputting the three-dimensional model of the fractured vertebral body into a preset bone cement anti-leakage planning model, and outputting a bone cement injection anti-leakage planning scheme; wherein the bone cement injection anti-leakage planning scheme at least comprises the viscosity, the injection amount, the injection position, the injection opportunity and the injection rate of the bone cement. According to the embodiment of the invention, the anti-seepage planning of bone cement injection can be carried out quickly and accurately.

The invention discloses manganese and cerium co-doped modified sodium niobate, which is prepared from Nb2O5, MnO2, CeO2 and sodium hydroxide. The invention further discloses magnesium-based bone cement with the sonodynamic / nano-enzyme antibacterial function and the piezoelectric osteogenesis function. The magnesium-based bone cement is prepared from CaHPO4, NaH2PO4, MgO powder, hydroxyapatite and manganese-cerium co-doped modified sodium niobate. The magnesium-based bone cement with sonodynamic / nano-enzyme antibiosis and piezoelectric osteogenesis provided by the invention has piezoelectric enhanced sonodynamic and nano-enzyme synergistic antibacterial activity and piezoelectric osteogenesis activity, effectively removes bacteria / biological membranes, realizes combination of antibiosis and bone repair under different ultrasonic powers, effectively treats infectious bone defects, and has a good application prospect. The treatment effect of the MPC basal bone repair material is obviously improved.

A bone insert includes a cap having a convex top surface, an elongated stem, and a barrier between the cap and the stem. The stem of the bone insert is inserted into a hole formed in a host bone until the barrier is pressed against the exposed bone. The bone implant can be placed against a small focus contact point on the cap. Liquid cement can be injected into a space volume between the host bone and a bone implant. The cap can be made of a material and / or have surface features that create a strong bond with the cement when the liquid cement cures. The stem can be made of a material and / or have bone ingrowth surface features that create a strong bond with the bone.

The invention provides a diphosphonate with a molecular structure containing a single acryloyloxy group and a single quaternary ammonium cation, the diphosphonate is used as a functional acrylate monomer and a functional acrylate cross-linking agent, and the functional acrylate monomer is expected to be mixed into MMA (Methyl Methacrylate) for a copolymerization reaction to prepare the copolymerization modified PMMA-based bone cement. Meanwhile, the antibacterial and bacteriostatic performance of the PMMA powder, the medical efficiency of the bisphosphonate and the water absorption expansion performance in a medium are improved, the elastic modulus is reduced, the tensile strength is improved, the curing heat effect is low, the biocompatibility is improved, and optimization or improvement of multiple technical indexes of the PMMA-based bone cement is achieved.

The invention provides high-bending-resistance injectable magnesium phosphate bone cement. The high-bending-resistance injectable magnesium phosphate bone cement is prepared from solid-phase powder, reinforcing filler and water, the solid-phase powder comprises the following components in parts by weight: 50-70 parts of magnesium phosphate salt and 30-50 parts of hydrogen phosphate, and the magnesium phosphate salt comprises trimagnesium phosphate; the reinforcing filler comprises a polyurethane modified epoxy resin emulsion; based on the polyurethane modified epoxy resin emulsion with the solid content of 30%-50%, the mass fractions of the solid phase powder, the reinforcing filler and the water in the bone cement are 66-70 wt%, 1-7 wt% and 23-33 wt% respectively. The high-bending-resistance injectable magnesium phosphate bone cement is high in bending strength and suitable for bone defect areas bearing multidirectional loads.

The invention relates to a bone cement injection device for skull repair. The bone cement injection device comprises an outer sheath tube, a separate injection structure and an outer push rod, a pushing channel extending in the axial direction is formed in the outer sheath tube, the tube wall of the outer sheath tube is provided with a first hole group and a second hole group which are symmetrically distributed by 180 degrees in the circumferential direction, and each hole group comprises a plurality of via holes arranged at equal intervals in the axial direction; the two symmetrically-arranged separated injection structures are arranged corresponding to the first hole set and the second hole set respectively, each separated injection structure comprises a separated injection pipe, the separated injection pipe is inserted into the pushing channel, a perfusion channel extending in the axial direction is arranged in the separated injection pipe, the near end of the perfusion channel is through, and the far end of the perfusion channel is closed; the rigid contact pins are arranged at equal intervals in the axial direction of the separate injection pipe and penetrate through the side wall of the separate injection pipe at the same circumferential angle, and the inner end of each contact pin is communicated with the perfusion channel. The repairing block can be effectively filled with bone cement, and the effect after skull repairing is improved.

The invention relates to a method and device for preventing bone cement leakage, electronic equipment and a storage medium, and the method comprises the steps: determining a first operation method according with the illness state information of a current patient and a first material parameter of a postoperative bone from a historical case, and the first operation method comprises a first operation parameter; based on the first operation method, the first material parameters and a preoperative three-dimensional model of a fractured vertebral body of the current patient, simulating the diffusion condition after bone cement is injected into the body according to the first operation method, and obtaining a first prediction form representing the diffusion condition of the bone cement; using an evaluation model to evaluate the first operation method based on the first prediction form to obtain a reference evaluation score; on the basis of the benchmark evaluation score, the first operation parameter is adjusted with the purpose of improving the evaluation score, and the target operation method is obtained. By means of the method, the bone cement leakage risk can be reduced, and bone cement leakage is effectively prevented.

This invention relates to a treatment device suitable for combined operative procedure of vertebroplasty and pediculoplasty. A treatment device includes a cylindrical driver capable of driving a screw into bone, an inner sleeve capable of being inserted into the driver, and a guide pin capable of being inserted into the inner sleeve, and is configured as follows. The screw includes on an outer wall (outer circumference) a thread that can tap into bone or cement, and a through hole that allows the inner sleeve to pass from a head to a tip. The driver can fit onto the head of the screw and when moved along the central axis and be joined to the screw, so as to transmit torque about the central axis to the screw. The inner sleeve includes a notch which protrudes, when the inner sleeve is inserted from the distal end of the driver in a state in which the screw and the driver are joined together, protrudes more proximally than a tip of the screw, preventing removal of the screw.

The invention discloses a screw feeding device which is suitable for a pedicle screw. The screw feeding device comprises an implanting mechanism and a torque applying mechanism which are in transmission connection with a pedicle screw; the torque applying mechanism is configured to be in an engaged state and a disengaged state with the implanting mechanism; when the torque applying mechanism and the implantation mechanism are in a joint state, the torque applying mechanism can transmit torque to the implantation mechanism; and when the torque applying mechanism and the implanting mechanism are in a separated state, the torque applying mechanism is separated from the implanting mechanism, so that the torque is prevented from acting on the implanting mechanism in the exiting process of the torque applying mechanism, and the pedicle screw is prevented from loosening. According to the vertebral pedicle screw, the operation time can be shortened, the operation steps can be simplified, the cooperation among instruments can be optimized, the complex operation of a surgeon on the cooperation of the instruments can be reduced, the vertebral pedicle screw cannot be loosened, and bone cement can be rapidly placed at the same time, so that the possibility of bone cement leakage and embolism can be reduced.

The invention discloses a bone cement propelling device, and relates to the technical field of medical instruments. The two ends of the pipe body structure are a propelling section and a front end respectively, and a hole is formed in the side wall of the front end to form an outlet; and the push rod acts to enable the contents in the pipe body structure to flow out from the outlet. Bone cement can be injected and distributed in a stress concentration area where the end plate is in contact with the fusion cage, a bone grafting area in the middle of the fusion cage is avoided, and therefore the purpose of balancing end plate strengthening and blood supply is achieved. According to the bone cement injection device, the number of bone cement outlets and the injection position can be adjusted through relative rotation of the outer pipe and the inner pipe, and the first injection hole structure and the second injection hole structure are selectively aligned through rotation between the outer pipe and the inner pipe; therefore, at least one outlet or a combination form of two or more outlets can be formed in the tube body structure, the injection position and the injection amount of bone cement can be adjusted according to actual treatment work, and the functions of fixed-point injection and quantitative injection are achieved.

The invention comprises a system for securing an implant to a bone comprising an implant which is affixed to the bone, a grout or bone cement comprising a composition that cures in an exothermic reaction and which is capable of securing the implant to the bone in a cured state, a device which provides access to the grout or bone cement in position on the bone and a tester which measures temperature over time to detect the exothermic reaction so as to determine when the composition reaches cure. The tester comprises a sensor joined to a circuit and to an indicator that emits a signal in response to a current emitted to the circuit by the sensor.

The invention relates to the technical field of orthopedic biomedical treatment, in particular to a proximal humerus fracture intramedullary bone cement supporting rod. The bone fracture plate comprises a bone fracture plate body, a plurality of first connecting holes and a plurality of second connecting holes are formed in one side of the bone fracture plate body in a penetrating mode, and solid bone nails are arranged in the first connecting holes. According to the device, bone cement is injected into a marrow cavity from an injection molding channel and an injection molding opening and then solidified into a rod body, the marrow cavity space is tightly filled, supporting structures are synchronously formed on the inner side and the outer side of the humerus through cooperation of a bone fracture plate and a bone cement supporting rod in the marrow cavity space, and therefore stress generated when arms of a patient move is evenly dispersed on the two sides of the humerus; the fixing stability is remarkably improved, the risk of internal fixation failure such as steel plate displacement and screw cutting is effectively reduced, and the bone cement supporting rods can further prevent displacement of fracture blocks, promote fracture repair, relieve extrusion and friction of surrounding tissue of a filling position, reduce inflammatory response and postoperative pain and improve the rehabilitation comfort of a patient.

The invention relates to the technical field of biological tissue adhesives, in particular to a biological tissue adhesive composition. The biological tissue adhesive composition comprises a powder A, a powder B and a powder C, wherein the powder A is obtained by curing calcium silicate and acidic calcium phosphate in a curing liquid, curing, drying and crushing; powder B: bivalent metal salt; powder C: phosphorylated amino acid; and an aqueous solvent; the biological tissue adhesive is used for bone adhesion and bone repair. According to the biological tissue adhesive composition provided by the invention, a silicate / hydroxyapatite composite material with a bone induction function is synthesized through optimized bone cement reaction, a curing liquid is added to react with phosphorylated amino acid, and a bone adhesive material is obtained through organic and inorganic material coordination reaction; the bone repairing and regenerating capability and the bone bonding capability are good.

The invention discloses a bone filling device and belongs to the technical field of medical instruments.The bone filling device comprises a main body module, a vibration module, a mixing module and a discharging module, the main body module comprises a mounting frame, a vibration tank is fixedly connected to the bottom of the inner wall of the mounting frame, and a filling pipe is connected to the bottom of the vibration tank; a lifting groove is formed in the front end face of the mounting frame, a piston rod is slidably connected into the lifting groove, and the bottom end of the piston rod extends into the vibration tank and is fixedly connected with a pressing plate. By means of the structure, internal vibration and external knocking can be conducted on bone cement, so that the bone cement can be loosened to enable bubbles to float upwards, it is avoided that the bubbles are moved and injected to affect the strength of subsequent prostheses, the bone cement injection quality is improved, and the subsequent fracture risk is reduced.

A device for producing bone cement, comprising a base part which has a container for receiving a monomer liquid, a bottom part with a collection region, and a hollow mandrel with a tip, and a cartridge for receiving a PMMA bone cement powder, wherein the cartridge has a septum which delimits the cartridge toward the outside, wherein the device is designed and configured to form a fluid-conducting connection between the base part and the cartridge by the hollow mandrel piercing the septum so as to transfer a monomer liquid from the collection region into the cartridge.

The invention discloses a bone cement composition and application thereof, and relates to the technical field of bone cement. The bone cement composition comprises a solid phase component and a liquid phase component, wherein the solid phase component comprises 60-75 parts of composite calcium phosphate, 10-20 parts of strontium glass powder, 8-12 parts of a reinforcing agent and 3-7 parts of a solidification reaction regulator; the liquid phase component comprises 20-30 parts of a phosphate buffer solution, 3-8 parts of a sodium citrate solution, 5-15 parts of an anti-inflammatory agent and 1-5 parts of a hyaluronic acid solution. The preparation method comprises the following steps: reacting 1, 10-phenanthrene-2, 9-dicarboxylic acid with 2-aminomethyl furan to obtain an intermediate 1, and reacting the intermediate 1 with poly (ethylene glycol) maleimide to prepare the reinforcing agent. The prepared bone cement composition has good mechanical properties, self-repairing performance and anti-inflammatory performance, and has a good application prospect in the field of bone repairing.

The invention discloses a bone cement composite material with collapse resistance and a preparation method thereof, and belongs to the technical field of biomedical materials. The composite material comprises a solid phase part and a liquid phase part, the liquid phase part and the solid phase part are mixed according to the liquid-solid ratio of 0.35 mL / g to 0.6 mL / g; the solid phase part is composed of calcium sulfate powder and calcium phosphate powder, and the mass ratio of the calcium sulfate powder to the calcium phosphate powder is 85: 15; the liquid phase part is selected from carboxymethyl chitosan or a combination of carboxymethyl chitosan and sodium alginate. The bone cement composite material prepared by the preparation method disclosed by the invention has good biocompatibility; due to a gel network formed by carboxymethyl chitosan and sodium alginate, the compressive strength of the bone cement is remarkably improved, and the collapse resistance and injectable performance are excellent; meanwhile, the bone cement composite material promotes the attachment and proliferation of osteoblasts, and can induce osteogenic differentiation in vitro.

The utility model discloses a pelvic brittle fracture bionic hollow screw manufactured based on the 3D printing technology. The pelvic brittle fracture bionic hollow screw manufactured based on the 3D printing technology comprises a screw body, and the screw body comprises a screw tail, a supporting part and a screw head; a thread, a diversion trench and a microporous structure are arranged on the supporting part; the micropore structure comprises a plurality of point position sets spirally arranged on the supporting part, and the difference between every two adjacent point position sets is one fourth of the circumference. According to the pelvic brittle fracture bionic hollow screw manufactured based on the 3D printing technology, the screw body manufactured through the D printing technology is arranged, a micro-pore structure distributed in a topological configuration mode can be conveniently arranged on the screw body, bone cement can be conveniently spread around the screw body in a more dispersed mode through the micro-pore structure, and therefore the bone cement can be more evenly distributed on the periphery of the screw body. And the micropore structure is beneficial to bone tissue growth, so that the long-term stability of the screw is improved.

Various bone cement guides are disclosed that may connect directly to a fenestrated bone screw or connect to a spinal construct that is coupled to a fenestrated bone screw. In various embodiments, cement guides may include a three-part assembly including a hollow outer sleeve and a hollow inner sleeve with a removable inner rod. In various embodiments, the hollow inner sleeve may be movable between a retracted position and an extended position and in the extended position a distal end of the inner sleeve may splay outward and capture the head portion of a fenestrated bone screw. In other embodiments, a distal end of the outer sleeve may surround and capture tabs of an extended tulip head connector while the inner sleeve couples to an inside surface of the extended tulip head connector.

The utility model discloses a bone cement cannulated screw assembly which comprises a cannulated screw and an injector, the cannulated screw comprises a screw cap and a screw rod constructed to be of a hollow structure, the screw cap and the screw rod are integrally formed, an injection hole is formed in the screw cap, the injection hole is communicated with the hollow structure of the screw rod, threads are arranged on the screw rod, and a plurality of outflow holes are formed in the side face of the screw rod; the injector comprises a partition plate and an injection cylinder, the injection cylinder is detachably connected with the hollow nail, the hollow nail is screwed into the fracture position after the injection cylinder is connected with the hollow nail, an insertion groove is formed in the side wall of the injection cylinder, the partition plate slides in the insertion groove, and after the partition plate slides in the insertion groove in the first direction, the injection cylinder is partitioned to form a stirring groove. The bone cement stirring device has the function of rotating the hollow nail, can stir bone cement in the separated stirring grooves, can directly inject the bone cement into a fracture position, prolongs the solidification time of the bone cement, and improves the operation effect.

The invention provides an extramedullary 3D printing composite intramedullary fixing bone end broach system, and relates to the technical field of medical instruments. Comprising a bone prosthesis and a fixing system, and the fixing system comprises a broach which is arranged at one end of the bone prosthesis and is fixed in a medullary cavity through bone cement; the fixing piece is arranged at the end, close to the broach, of the bone prosthesis and makes contact with the host bone, and the contact face is a 3D printing interface; the preset part is used for replacing the fixing part to make contact with the host bone in the prosthesis mounting operation. According to the fixing system, the broach, the fixing part and the preset part are used in cooperation, bone cement in a medullary cavity is fixed through the broach, and 3D interface fixing is adopted through the fixing part, so that the bone prosthesis has good bone conductivity and mechanical stability in a long term and a short term; and the influence on bone ingrowth caused by the fact that bone cement falls into a 3D contact interface of the fixing piece in a prosthesis installation operation is avoided.

The invention provides a femoral stem prosthesis. The femoral stem prosthesis comprises a femoral stem, an expansion component and a sleeve. The femoral stem is composed of an upper stem body and a replaceable lower stem body, and threads are arranged in the femoral stem. The expansion part is located in the upper handle body and comprises a screw, a rotating disc and a multi-layer pushing structure. The screws are connected with the upper and lower handle bodies through threads; and the turntable is in threaded engagement with the screw and can drive the first pushing part along the first guide rail during rotation. Ratchets are arranged in the rail component and meshed with the pawls of the second pushing part, and an open hole is formed in the side of the second pushing part. And the sleeve is linked with the expansion component through the fifth pushing part, the fourth pushing part and the third pushing part. During implantation, the second pushing part outwards pushes the sleeve to be attached to the wall of the medullary cavity, the internal pushing structure acts successively under the counter-acting force, and finally the first pushing part is separated from the second pushing part. Then bone cement is injected through a sleeve micropore, and the stability of the prosthesis is enhanced. By means of the design, intraoperative adaptation and stable filling are achieved.

The invention discloses copper selenide / tricalcium silicate bone cement. The bone cement comprises a liquid phase component and a solid phase component, the liquid phase component is water, and the solid phase component is tricalcium silicate powder and copper selenide nanoparticles. Compared with the existing tricalcium silicate bone cement, the tricalcium silicate bone cement has the advantages that by introducing a trace amount of copper selenide nanoparticles, not only can the hydration and coagulation time of tricalcium silicate be shortened, but also the porosity and degradation rate of the tricalcium silicate after coagulation and solidification can be reduced, the compressive strength can be improved, the stimulation effect on ALP activity of MC3T3-E1 cells can be enhanced, the survival rate of the MC3T3-E1 cells can be improved, and the application prospect is broad. The immunogenic apoptosis of K7M2-wt cells is promoted, and the tumor growth rate is reduced. Besides, the introduction of the copper selenide nanoparticles can also endow the tricalcium silicate bone cement with the performance of temperature rise under near-infrared light, so that in clinical application, the tricalcium silicate bone cement can be further combined with a near-infrared technology to realize ablation of bone tumors, and a new strategy is provided for treatment of the bone tumors.

The present invention relates to the technical field of medical devices, and proposes a proximal femoral fixation steel plate, comprising a steel plate body and a first screw, wherein the first screw comprises a nail tube, a rotating cylinder and a drill rod, wherein the nail tube penetrates and is slidably arranged in the steel plate body, and the peripheral side of the nail tube is provided with an annular groove and a first through hole that are interconnected; the rotating cylinder is rotatably arranged in the annular groove, and the peripheral side thereof is provided with an interconnected reinforcement groove and a second through hole; the drill rod is fixedly arranged on the rotating cylinder, and its length direction is parallel to the axial direction of the nail tube, and the side away from the axis of the nail tube is spaced from the peripheral side of the rotating cylinder. The present invention arranges a rotating cylinder and a drill rod on the nail tube, and when the nail tube is screwed into the femur, the drill rod can be driven to move along the axial direction of the nail tube, so as to open a line groove for storing bone cement on the inner wall of the femoral borehole, which not only improves the degree of fixation of the first screw and the femur, but also reduces the damage area of ​​the femur to the drill rod.

The invention relates to the technical field of biomedical materials, in particular to a preparation process of novel composite bone cement with biological activity, which comprises the following steps: calcining calcium phosphate in a calcining furnace at 800-1000 DEG C for 3 hours, cooling to 20 DEG C, grinding the calcium phosphate by using a grinding machine until the diameter is less than 100 mu m, and drying to obtain the novel composite bone cement with biological activity. Calcium phosphate micro powder is obtained; by fusing the calcium phosphate, the nano-hydroxyapatite, the bioglass and the collagen, the material has a mechanical support function of an inorganic phase and biological activity of an organic phase, the nano-hydroxyapatite is extremely similar to human bone minerals and can promote osteoblast attachment and growth, and the collagen constructs a bionic microenvironment and accelerates new bone formation, so that the material can be used for treating osteoporosis. The bone repair efficiency is obviously improved.

The utility model discloses a stirrer for EH composite bone cement production, the EH composite bone cement is composed of powder and liquid, mainly composed of inorganic material HA and organic material EAM, the stirrer comprises a shell, the shell is a hollow cylinder, the upper surface of the shell is provided with a feed pipe, the lower end of the feed pipe penetrates through the upper surface of the shell, and the lower end of the feed pipe is connected with the lower end of the shell. A discharging pipe is arranged on the lower surface of the shell, and a valve is arranged in the discharging pipe to control opening and closing. The stirrer for producing the EH composite bone cement is provided with the two symmetrical stirring rods, the driven wheels are arranged on the surfaces of the stirring rods, the driven wheels are of gear structures, the two driven wheels are engaged with the driving wheel, and the driving wheel is of a tooth-missing gear structure, so that in the rotating process of the driving wheel, the stirring rods on the two sides are driven to rotate asynchronously; and the raw materials in the shell are fully stirred.

The invention discloses a preparation method of a gradient pore-forming magnesium-containing calcium phosphate bone repair material, which comprises the following steps: S1, mixing nano-hydroxyapatite with polylactic acid-glycolic acid copolymer (PLGA) powder, adding dichloromethane as a solvent, continuously stirring to form a solution, and freeze-drying to obtain an nHA / PLGA raw material, and carrying out high-temperature fused deposition through a 3D biological printer to prepare the degradable nPLGA stent. S2, weighing the calcium phosphate bone cement powder and the magnesium metal microspheres according to a preset mass ratio, stirring the slurry and homogenizing to obtain calcium phosphate bone cement slurry containing the magnesium metal microspheres; s3, injecting the calcium phosphate bone cement slurry obtained in the step S2 into the nPLGA stent prepared in the step S1 to obtain an MC / nPLGA compound; gradient micropores are generated through hydration reaction of the magnesium microspheres, the gradient micropores and macropores formed by degradation of PLGA form a complementary structure, and the total porosity reaches 68% and is increased by 3.4 times compared with traditional CPC.