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33 results about "Bone volume" patented technology
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BV/TV stands for Bone Volume over Total Volume. It indicates the fraction of a given volume of interest (VOI, i.e. the Total Volume TV) that is occupied by mineralized bone (Bone Volume).
Multi-Directional fasteners or attachment devices for spinal implant elements
InactiveUS6019759AIncreased bone volumeAvoid damageSuture equipmentsInternal osteosythesisMultiple pointSpinal implant
An apparatus, method and system for treating spinal conditions by moving or spatially fixing at least one vertebra relative to another vertebra. The invention includes a link member the ends of which are configured to be secured to adjacent vertebrae and which are offset from a central portion of the link member. The link members can be in the form of a C-shaped or V-shaped rod or plate to form the offset. The offset provides increased bone volume that can be used for grafts or fusion. Attachment structure in the form of bone screws, bolts, or hook members are provided to secure the link members to respective vertebrae or other bones. A plurality of link members can be connected in chain-like fashion to connect multiple points on a plurality of vertebrae or other bones even though those points are nonlinear. In another aspect of the invention, a multi-directional attachment member is provided and may be used with the link members to form a spinal implant or external bone fixation system.
Owner:ROGOZINSKI CHAIM
Systems and methods for treating fractured or diseased bone using expandable bodies
Systems and methods treat fractured or diseased bone by deploying more than a single therapeutic tool into the bone. In one arrangement, the systems and methods deploy an expandable body in association with a bone cement nozzle into the bone, such that both occupy the bone interior at the same time. In another arrangement, the systems and methods deploy multiple expandable bodies, which occupy the bone interior volume simultaneously. Expansion of the bodies form cavity or cavities in cancellous bone in the interior bone volume.
Owner:ORTHOPHOENIX
Systems and methods for treating fractured or diseased bone using expandable bodies
Systems and methods treat fractured or diseased bone by deploying more than a single therapeutic tool into the bone. In one arrangement, the systems and methods deploy an expandable body in association with a bone cement nozzle into the bone, such that both occupy the bone interior at the same time. In another arrangement, the systems and methods deploy multiple expandable bodies, which occupy the bone interior volume simultaneously. Expansion of the bodies form cavity or cavities in cancellous bone in the interior bone volume.
Owner:ORTHOPHOENIX
Methods and systems for evaluating bone lesions
Methods and systems for evaluating bone lesions include accessing a first dataset acquired from a patient with a first imaging modality and a second dataset acquired from the patient with a second imaging modality. A segmentation is performed on the first dataset to identify a subset of the first dataset corresponding to a skeletal structure of the patient and a patient skeletal metric representing a total bone volume of the patient is automatically calculated from the subset of the first dataset. The methods and systems further include detection of at least one lesion in the second dataset, classification of the at least one lesion as a bone or non-bone lesion, automatic calculation of a bone lesion metric based on the classification, and calculation of a lesion burden as a ratio of the bone lesion metric and the patient skeletal metric.
Owner:GENERAL ELECTRIC CO
Dental implant for a jaw with reduced bone volume and improved osseointegration features
ActiveUS20090011384A1Promote osseointegrationReduce volumeDental implantsDentistry preparationsOsseointegrationDental implant
A dental implant has a body with a porous metal portion for engaging bone. The porous metal portion has an outer coronal to apical height and an outer diameter. Both the height and diameter are about 4 mm to about 6 mm. This permits the implant to be placed on a jaw with a reduced bone volume.
Owner:ZIMMER DENTAL INC
Compositions and methods for treating the vertebral column
ActiveUS20100183515A1Increasing bone mineral densityLess susceptiblePowder deliveryPeptide/protein ingredientsBone formationVolumetric Mass Density
The present invention relates to compositions and methods useful for treating structures of the vertebral column, including vertebral bodies. In one embodiment, a method for promoting bone formation in a vertebral body comprising providing a composition comprising a PDGF solution and a biocompatible matrix and applying the composition to at least one vertebral body. Promoting bone formation in a vertebral body, according to some embodiments, can increase bone volume, mass, and / or density leading to an increase in mechanical strength of the vertebral body treated with a composition of the present invention.
Owner:BIOMIMETIC THERAPEUTICS INC
Dental implant for a jaw with reduced bone volume and improved osseointegration features
ActiveUS8562346B2Promote osseointegrationReduce volumeDental implantsDentistry preparationsOsseointegrationDental implant
A dental implant has a body with a porous metal portion for engaging bone. The porous metal portion has an outer coronal to apical height and an outer diameter. Both the height and diameter are about 4 mm to about 6 mm. This permits the implant to be placed on a jaw with a reduced bone volume.
Owner:ZIMMER DENTAL INC
Active part of Sambucus williamsii Hance for reducing risk of bone-related diseases of menopausal women and application thereof
ActiveCN101773490AImprove bone lossHigh densityEther/acetal active ingredientsSkeletal disorderFood additiveGlycerol
The invention discloses an active part of Sambucus williamsii Hance with the effect of reducing bone mass loss after menopause. The active part has definite chemical components and mainly comprises seven compounds: vanillic acid, coniferol, levo erythro form guaiacyl glycerol-beta-O-4'-coniferyl alcohol ether, dextro threo form-1-(4-hydroxy-3-methoxyphenyl)-2-[-4-(3-hydroxypropyl)-2-hydroxyphenoxy]-1,3-propanediol, dextro threo form guaiacyl glycerol-beta-O-4'-coniferyl alcohol ether, coniferyl alcohol dehydrogenase and dihydro-coniferyl alcohol dehydrogenase. The active part can remarkably reduce the bone loss of ovariectomized mice, increase bone density of thighbone and shinbone, increase bone volume, does not increase the weight of uterus, and is a component for safely and effectivelyrelieving and improving various symptoms of the bone-related diseases of the menopausal women. The invention has the advantages of providing the active part of the Sambucus williamsii Hance which canbe used for preparing a medicament, food or a food additive for preventing and treating the bone-related diseases after menopause.
Owner:THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST +1
Application of chickpea sprout extracts in medicines for preventing deficiency of estrogen
InactiveCN102488740AIncrease bone densityIncrease wet weightSkeletal disorderSexual disorderHormone Receptor ModulatorsEstrogen receptor
The invention relates to application of chickpea sprout extracts in medicines for preventing deficiency of estrogen. The chickpea sprout extracts are chickpea sprout isoflavone extracts, are used as estrogen receptor regulator, and are used for preparing medicines and health care products which are used for preventing or treating climacteric syndrome and osteoporosis. Tests show that the chickpea sprout isoflavone extracts can directly act onto the uterus of a patient, can remarkably increase estradiol level in blood serum, have regulating and controlling effects to a hypothalamus-hypophysis- neuroendocrine system, remarkably increase thighbone density and relative bone volume of an SD (Sprague Dawley) rat without the ovary, increase the thickness of bone trabecula, reduce separating degree of the bone trabecula, decrease the quantity of osteoclast, can alleviate bone loss of the thighbone of the rat due to the fact that the ovary of the rat is removed, increase bearing capacity of the thighbone, play an important role in regulating internal secretion conditions of middle-aged and elderly women after menopause, improving menopause symptoms such as hot flash, palpitate, skin dryness and the like and reducing possibility of osteoporosis, and lay a foundation in industrial development of functional factors of chickpeas.
Owner:XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
Method for making a surgical guide for bone harvesting
ActiveCN105848593AReach different depthsImage enhancementImage analysisBiomedical engineeringBone volume
The invention relates to a method for making a surgical guide (1) for performing bone harvesting (O), including: generating a three-dimensional image (20) of at least one portion of a bone of a patient (Pa) where said harvesting is to be performed, said bone defining an outer surface (4); identifying in said three-dimensional image (20) one or more sensitive anatomic structures (21) that must not be involved in said bone harvesting; identifying in said three-dimensional image (20) a volume (30) of bone suitable for being removed in said bone harvesting, said volume excluding said sensitive anatomic structures, and said volume being delimited by a portion (6) of said outer surface (4) of said bone defining a perimeter (31) and by a mantle (38) extending from said perimeter inside said bone, said mantle including, for each point of said perimeter, a segment forming a predetermined angle (a,b) with said portion of outer surface, said angle corresponding to a cutting direction (L1, L2, L3, L4) inside said bone identified in said three-dimensional image;designing said surgical guide (1), said guide defining a guide surface (8) suitable for being rested on said outer surface (4) of said bone, said guide surface comprising a work area (2) delimited by guide walls (5a,5b,5c,5d), said work area having a perimeter (3) corresponding to the perimeter (31) of said portion of surface (6) of said bone identified in said three-dimensional image; angling at least one of said walls with respect to said guide surface (5a,5b,5c,5d), so that said wall includes a face (7a,7b,7c,7d) that constitutes a geometrical extension of a portion of said mantle (38) of said bone volume (30), when said guide is rested on said outer surface of bone, so that said face includes, for each point of said perimeter of work area, a segment forming a predetermined angle with respect to said guide surface.
Owner:GADE SURGERY 2 0 LTD
Application of probiotics and their outer membrane vesicles in the preparation of drugs for the prevention and treatment of osteoporosis
ActiveCN108379297BReduce bone lossIncrease volume fractionBacterial antigen ingredientsSkeletal disorderMicrobiologyBone volume fraction
Owner:湖南鹤螈生物科技有限公司
Application of probiotics and outer membrane vesicles thereof to preparing medicines for preventing and treating osteoporosis
ActiveCN108379297AReduce bone lossIncrease volume fractionSkeletal disorderUnknown materialsMedicineBone volume fraction
The invention discloses application of probiotics or outer membrane vesicles thereof to preparing medicines for preventing and treating osteoporosis. The probiotics is an Akk bacterium. The probioticsor the outer membrane vesicles of the probiotics can be used for increasing the bone volume fractions of distal-end cancellous bones of femurs, increasing the numbers of bone trabeculas and loweringthe separation of the bone trabeculas. The probiotics or the outer membrane vesicles of the probiotics can be used for preparing the medicines, food or healthcare products for preventing and treatingpostmenopausal osteoporosis. The application has the advantage that novel, safe and effective biotherapy directions can be provided to treating the osteoporosis and particularly the postmenopausal osteoporosis by the application.
Owner:湖南鹤螈生物科技有限公司
Methods and systems for evaluating bone lesions
Methods and systems for evaluating bone lesions include accessing a first dataset acquired from a patient with a first imaging modality and a second dataset acquired from the patient with a second imaging modality. A segmentation is performed on the first dataset to identify a subset of the first dataset corresponding to a skeletal structure of the patient and a patient skeletal metric representing a total bone volume of the patient is automatically calculated from the subset of the first dataset. The methods and systems further include detection of at least one lesion in the second dataset, classification of the at least one lesion as a bone or non-bone lesion, automatic calculation of a bone lesion metric based on the classification, and calculation of a lesion burden as a ratio of the bone lesion metric and the patient skeletal metric.
Owner:GENERAL ELECTRIC CO
Application of group of thio-matrine derivative and salts thereof to preparation of anti-osteoporosis medicament
ActiveCN106822118AImprove stabilityImprove bioavailabilityOrganic active ingredientsSkeletal disorderBone TrabeculaeThio-
The invention relates to application of a group of thio-matrine derivative and salts thereof to preparation of an anti-osteoporosis medicament. The structural general formula of the thio-matrine derivative is shown in the description, where X is a sulfur atom, and an R group is selected from a hydrogen atom, an alkyl group, halogen, nitryl and a cyano group. The group of compositions is proven by bioactivity tests to remarkably reduce the bone mass loss of an ovariectomized mouse, represented by increase of the number of bone trabeculae, the bone surface and bone volume ratio, the relative bone volume or bone volume fraction and the number of bone trabecula connections, and remarkably suppress differentiation of RAW264.7 cells and primary monocytes of the mouse to osteoclasts, and thus can be developed into an anti-osteoporosis medicament or used for preparing a reagent for researches on pathological mechanism of osteoporosis and evaluation of the curative effect of the anti-osteoporosis medicament.
Owner:SHANGHAI CHANGHAI HOSPITAL
Compositions and methods for treating the vertebral column
InactiveCN101820895ASurgical adhesivesPeptide/protein ingredientsBone formationVolumetric Mass Density
The present invention relates to compositions and methods useful for treating structures of the vertebral column, including vertebral bodies. In one embodiment, a method for promoting bone formation in a vertebral body comprising providing a composition comprising a PDGF solution and a biocompatible matrix and applying the composition to at least one vertebral body. Promoting bone formation in a vertebral body, according to some embodiments, can increase bone volume, mass, and / or density leading to an increase in mechanical strength of the vertebral body treated with a composition of the present invention.
Owner:BIOMIMETIC THERAPEUTICS INC
Pharmaceutical composition for the treatment of diminution of bone tissue
ActiveUS20160158152A1Lower Level RequirementsInhibits bone turnoverOrganic active ingredientsSkeletal disorderBone tissueMedicine
A method for prevention and / or treatment of diminution of bone tissue using a composition comprising a compound selected from Withaferin A (WFA), Withanolide A, and Withanone. The composition showed enhanced WFA bioavailability in rodents against plain WFA, promotes bone marrow cell differentiation, and increases the percent of bone volume to tissue volume (BV / TV%) by 3 folds as compared to free Withaferin A (WFA).
Owner:COUNCIL OF SCI & IND RES
Compositions and methods for treating the vertebral column
ActiveUS20160000972A1Promotes bone formationPreventing and decreasing likelihoodPowder deliveryPeptide/protein ingredientsMedicineBone formation
Owner:BIOMIMETIC THERAPEUTICS INC
Compositions and methods for treating the vertebral column
ActiveUS9161967B2Promotes bone formationPreventing and decreasing likelihoodPowder deliveryPeptide/protein ingredientsBone formationVolumetric Mass Density
Owner:BIOMIMETIC THERAPEUTICS INC
Parathyroid hormone treatment for enhanced allograft and tissue-engineered reconstruction of bone defects
InactiveUS20090227503A1Enhancing graft-host incorporationHigh strengthPeptide/protein ingredientsMetabolism disorderBone allograftBone defect
Methods of improving an outcome of a bone allograft procedure in a subject suffering from a massive bone defect are described, including providing a bone allograft to the subject and intermittently providing said subject with parathyroid hormone (PTH); where the PTH is provided in an amount effective to enhance in or adjacent to a bone allograft, relative to a patient not provided the PTH, at least one of callus bone volume, callus mineral content, callus bridging, graft stiffness, graft incorporation, and graft resistance to an applied torque.
Owner:UNIVERSITY OF ROCHESTER
Clec11a is a bone growth agent
ActiveUS20180110832A1Increase bone densityHigh strengthPeptide/protein ingredientsSkeletal disorderWhole bodyBone formation
The present disclosure describes the C-type lectin CLEC11a as a bone growth factor. Clec11a-deficient mice showed reduced bone volume and mineralization, while bone resorption remained unchanged. Administration of recombinant Clec11a systemically promoted bone formation in mice at risk for osteoporosis.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
Application of peptide MDP-1 to preparing of anti-osteoporosis medicine
InactiveCN105561291AImprove osteoporosisIncrease in sizePeptide/protein ingredientsSkeletal disorderBone TrabeculaeCytotoxicity
The invention discloses an application of peptide MDP-1 to preparing of anti-osteoporosis medicine. The amino acid sequence of the peptide MDP-1 is shown in SEQ. ID. NO.1. According to the application, an in-vivo experiment shows that by means of the peptide MDP-1, the indexes such as the ratio of the mouse bone volume to the tissue volume, the thickness of bone trabeculaes and the numbers of the bone trabeculaes of an estrogen-deficiency osteoporosis model can be increased, the indexes such as the ratio of the bone surface area to the bone volume and the separation degree of the bone trabeculaes can be decreased, differentiation of osteoclast can be inhibited, and cytotoxicity is avoided; in this way, the peptide MDP-1 can be used for preparing anti-osteoporosis medicine, and particularly the peptide MDP-1 can be used for preparing anti-postmenopausal osteoporosis medicine.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY
Pharmaceutical composition for the treatment of diminution of bone tissue
ActiveUS10596115B2Improve actionHigh densityOrganic active ingredientsCosmetic preparationsBone tissueBone marrow cell
Owner:COUNCIL OF SCI & IND RES
Establishment of zebra fish osteoporosis diagnostic standard
PendingCN114842966AFast imagingEasy to operateMedical simulationClimate change adaptationBone densityPhysiology
The invention discloses an establishment method of zebra fish osteoporosis diagnosis standards and a zebra fish osteoporosis diagnosis system. The method comprises the following steps: constructing a zebra fish osteoporosis model, scanning a zebra fish skull and / or spine by using Micro-CT, counting values of zebra fish bone density and bone volume percentage, calculating Mean + / -SD, calculating a T value through a Mean value and an SD value, judging, and further considering a bone mass loss value of a scanned part according to the bone density and / or bone volume percentage, so as to determine the osteoporosis of the zebra fish. The zebra fish osteoporosis diagnosis standard is obtained. The zebra fish osteoporosis diagnostic standard constructed by the invention can be directly used for evaluating medicines, and provides support for subsequent judgment of the degree of relieving bone loss by medicines. Diagnostic data support is provided for establishment of a zebrafish osteoporosis model, development of osteoporosis drugs and the like.
Owner:SUN YAT SEN UNIV
Application of peptide mdp-1 in the preparation of anti-osteoporosis drugs
InactiveCN105561291BImprove osteoporosisIncrease in sizePeptide/protein ingredientsSkeletal disorderBone TrabeculaeCytotoxicity
Owner:FOURTH MILITARY MEDICAL UNIVERSITY
Method of increasing bone volume
The present invention relates to novel methods of increasing bone volume comprising activating the osteoblastic protein kinase C / intracellular calcium pathways of a subject. This invention further relates to a method of treating or preventing bone disorders wherein activation occurs by the administration of a FP agonist.
Owner:THE PROCTER & GAMBLE COMPANY
Device for predicting femoral head collapse risk and using method and application thereof
PendingCN111839570AUnderstand the conditionReliable medical dataImage enhancementImage analysisRight femoral headDisease course
The invention provides a device for predicting the femoral head collapse risk and a using method and application thereof. The device comprises an image processing unit, an analysis unit, a separationunit, a calculation unit and an output unit. The device can obtain a plurality of data of the femoral head of a case according to the hip joint CT image of the case, wherein the data comprises hardened bone volume, soft tissue volume and total head bone density; the relation between each data and the disease course time of the case is obtained simultaneously, and the femoral head collapse risk ofthe case is calculated according to the total head bone density and the hardened bone volume of the case, thereby providing reliable medical data for clinical treatment of femoral head necrosis.
Owner:BEIJING UNIV OF CHINESE MEDICINE THIRD AFFILIATED HOSPITAL
Application of a group of thiomatrine derivatives and their salts in the preparation of anti-osteoporosis drugs
ActiveCN106822118BImprove stabilityImprove bioavailabilityOrganic active ingredientsSkeletal disorderBone TrabeculaeThio-
The invention relates to application of a group of thio-matrine derivative and salts thereof to preparation of an anti-osteoporosis medicament. The structural general formula of the thio-matrine derivative is shown in the description, where X is a sulfur atom, and an R group is selected from a hydrogen atom, an alkyl group, halogen, nitryl and a cyano group. The group of compositions is proven by bioactivity tests to remarkably reduce the bone mass loss of an ovariectomized mouse, represented by increase of the number of bone trabeculae, the bone surface and bone volume ratio, the relative bone volume or bone volume fraction and the number of bone trabecula connections, and remarkably suppress differentiation of RAW264.7 cells and primary monocytes of the mouse to osteoclasts, and thus can be developed into an anti-osteoporosis medicament or used for preparing a reagent for researches on pathological mechanism of osteoporosis and evaluation of the curative effect of the anti-osteoporosis medicament.
Owner:SHANGHAI CHANGHAI HOSPITAL
Method and device of estimating a dose of ionizing radiation
InactiveUS8766634B2Measurements using electron paramagnetic resonanceDiagnostic recording/measuringMicrowaveCubic Millimeter
A device of estimating a dose of ionizing radiation absorbed in an intra bone volume. The device comprises a static magnetic field source adapted to generate a substantially static magnetic field in a probing space having a volume of less than 2 cubic millimeter (mm3), the probing space being placed in front of a distal end of static magnetic field source, a micro resonator mounted in adjacent to the distal end, and at least one transmission line which feeds the resonator so as to generate an microwave magnetic field at the probing space and to transmit a signal returned from said microwave magnetic field and indicative of radiation induced paramagnetic defects in said probing space so as to allow a spectrometer to compute a dose of ionizing radiation absorbed in a portion of a bone placed in the probing space according to an analysis of the signal. The static magnetic field source being sized and shaped to maneuver the probing space to overlap with an intra bone volume of the bone.
Owner:TECHNION RES & DEV FOUND LTD
Formononetin derivative as well as preparation method and application thereof
The invention relates to the technical field of medicine synthesis, and provides a formononetin derivative as well as a preparation method and application thereof. The invention provides the derivative taking formononetin as a mother nucleus based on natural plant estrogen with anti-osteoporosis activity. The derivative has inhibitory activity on osteoclasts, can promote bone marrow mesenchymal stem cells to be differentiated into osteoblasts, and activates the bone forming ability of the osteoblasts; the expression of osteoblast related genes can be promoted, so that the balance of osteoclast and osteogenesis is improved; the level of bone mineral density in individuals with abnormal bone mineral density can be increased, the bone volume fraction in individuals with abnormal bone volume fraction can be increased, and the ratio of bone surface area to bone volume in individuals with abnormal ratio of bone surface area to bone volume can be adjusted; and the derivative has a wide application prospect in preparation of medicines for preventing or treating diseases or symptoms caused by osteoblast abnormality.
Owner:YUNNAN UNIV
Active part of Sambucus williamsii Hance for reducing risk of bone-related diseases of menopausal women and application thereof
ActiveCN101773490BImprove bone lossHigh densitySkeletal disorderEther/acetal active ingredientsFood additiveGlycerol
Owner:THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST +1
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