15 results about "Bone health" patented technology

The application discloses a functional composition for improving bone and joint health, a conditioner and application. The functional composition comprises a first active component and a second active component; the first active component comprises elastin peptide, haematococcus pluvialis and ergothioneine; and the second active component comprises one or more of houttuynia cordata and non-denatured type II collagen. The application realizes the protection effect on joint, cartilage and bone health by scientific matching of the components and synergistically improving the glycosaminoglycan level in chondrocytes and the osteocalcin level in osteoblasts. Meanwhile, the components in the functional composition for improving bone and joint health are natural and have good biocompatibility, and have no obvious side effects, so that the application provides a kind of drug or a substitute for the treatment and prevention of bone diseases.

The present invention relates to the use of a composition comprising an effective amount of a combination of fesoterodine and / or a derivative thereof and quercetin and / or a derivative for preventing or treating a bone disorder or maintaining bone health in an individual.

This utility model discloses a quantitative dispensing container for formulated milk powder for bone health in middle-aged and elderly people. It includes a mixing tank, a cover plate fixedly installed on the top of the mixing tank, an outer shell fixedly installed on the top of the cover plate, and a mounting plate rotatably connected to the inner top of the outer shell. A discharge pipe is fixedly installed on the left end of the top of the cover plate, and a baffle is sleeved and connected to the outside of the discharge pipe. A rotating component is located at the middle position of the top of the cover plate, and an adjusting component is located on the left end of the top of the cover plate. The discharge component is mounted on the mounting plate. This quantitative dispensing container for formulated milk powder for bone health in middle-aged and elderly people can effectively control the intake through the rotation of the discharge baffle, reducing the risk of insufficient or excessive intake, thereby ensuring the acquisition of appropriate nutrients. Furthermore, the shielding of the lower end of the hopper effectively prevents the milk from contacting air and also effectively prevents accidental powder leakage or splashing.

This invention discloses a composition with bone-health-promoting functions and its applications, belonging to the field of microbial engineering. The composition comprises milk calcium, colostrum basic protein, and Bifidobacterium breve i1088 powder. The composition provided by this invention, which has a synergistic effect between milk calcium, colostrum basic protein, and Bifidobacterium breve i1088 powder, enhances the conversion rate of calcium from the blood to bone through the action of probiotics, thereby improving the actual utilization rate of calcium and effectively promoting bone health. Experimental data show that this composition significantly increases bone mineral density, bone volume fraction, and trabecular thickness in a female rat osteoporosis model, and significantly reduces trabecular spacing in the same model. The composition provided by this invention is suitable for promoting bone health and preventing and / or improving osteoporosis.

This application discloses a composition, conditioning agent, and application for protecting bone health. The active ingredients of the composition for protecting bone health include purslane powder, cucumber powder, celery powder, and Solomon's seal powder. This application scientifically combines the four active ingredients to fully leverage their synergistic effects, effectively activating the Runx2 gene and its expression, promoting the production of bone matrix proteins, and significantly intervening in and improving bone discomfort caused by bone matrix protein deficiency. Furthermore, the composition uses naturally derived active ingredients, exhibiting high safety, excellent biocompatibility, and no obvious side effects. The good compatibility between the active ingredients allows for preparation into various dosage forms according to actual needs, making application convenient and with high compliance. Thus, this provides an effective functional active composition for protecting bone health.

This invention discloses a Hu sheep active peptide complex and its application in bone health care. Using healthy Hu sheep bones as raw material, collagen is extracted after defatting and decalcification. This collagen is then enzymatically hydrolyzed with trypsin and alkaline protease, followed by ultrafiltration, desalting, and freeze-drying to obtain Hu sheep bone collagen peptides. These collagen peptides are mixed with pharmaceutical excipients, calcium source compounds, chondroprotective agents, and fat-soluble vitamins. An ethanol-water binder solution containing palmitoyl aspartate diethyl ester and hesperidin-3-O-glucoside is added, and the mixture is granulated, dried, sized, and pressed to obtain the active peptide complex. This complex, through the synergistic effect of its components, can significantly promote osteoblast proliferation and inhibit apoptosis, effectively increasing bone density in osteoporosis model animals. It also exhibits excellent biocompatibility and no cytotoxicity, solving the problems of limited function, insufficient preparation efficiency, and instability of existing single active peptides. This makes it suitable for the development and application of bone health-related nutritional supplements.

The application provides a casein phosphopeptide with the functions of promoting the absorption of calcium, iron, zinc, manganese and magnesium and improving bone health and a preparation method, and belongs to the technical field of casein phosphopeptide and comprises the following steps: S1, taking casein and adding pepsin for first enzymolysis; S2, taking the first enzymolysis solution, adjusting pH and temperature, and adding a compound enzyme for second enzymolysis; S3, after the second enzymolysis solution is inactivated, the casein phosphopeptide is obtained through treatment. The casein phosphopeptide prepared by the application has the following advantages: 1. can effectively complex mineral elements and reduce ion channel competition inhibition; 2. promotes the absorption of calcium, increases the hardness of the skeleton, and promotes the growth and development of the skeleton; 3. promotes the absorption of magnesium, assists calcium deposition, reduces bone loss, prevents osteoporosis, 3. promotes the absorption of iron, prevents iron deficiency anemia, and improves uncomfortable symptoms such as dizziness and fatigue; 4. promotes the absorption of zinc, enhances the activity of immune cells, improves resistance, and improves appetite. 5. promotes the absorption of manganese, activates the development of the skeleton, accelerates energy metabolism, and has antioxidant effect.

This invention discloses a method and system for longitudinal bone mineral density prediction and high-risk window identification, belonging to the field of intelligent bone health assessment technology. Based on a large amount of localized population-based bone mineral density data assets, this invention preprocesses the data to construct a regionally adaptive dual-graph LSTM network for temporal bone mineral density prediction. It quantifies prediction uncertainty and generates confidence intervals using a Bayesian method, employs the PELT algorithm to detect bone mineral density evolution change points, and identifies the critical point of accelerated decline. By integrating prediction results, confidence intervals, and change point locations, a three-dimensional high-risk window is delineated, and personalized intervention plans are output, supporting multi-platform deployment. This invention solves the problems of inapplicability to traditional assessment standards, difficulty in capturing nonlinear changes, and insufficient prediction reliability, significantly improving the accuracy of bone mineral density prediction and the timeliness of clinical intervention. It is suitable for osteoporosis risk screening and primary healthcare management.

The present invention relates to the use of a composition comprising an effective amount of oleuropein and / or its metabolites in combination with fesoterodine and / or derivatives for the prevention or treatment of bone disorders or for the maintenance of bone health in an individual.

A use of a mangosteen shell extract for preparing a composition for improving bone health is provided. The mangosteen shell extract is prepared by performing a two-stage extraction on a fruit shell of mangosteen (Garcinia mangostana) using an enzyme solution at different extraction temperatures sequentially.

The present application belongs to the technical field of microbial fermentation, and particularly relates to Lactobacillus rhamnosus for maintaining bone health and improving local inflammation of joints, postbiotic and application thereof. The present application prepares a postbiotic product by fermenting and culturing probiotic NKU ML1-2. The results of examples prove that the postbiotic drug can enhance the antioxidant capacity of chondrocytes and osteoblasts, promote the synthesis of anti-inflammatory factors and cartilage matrix (type II collagen and proteoglycan), has the potential to reduce local oxidative stress and inflammatory response of joints, relieve joint inflammation, and delay cartilage destruction. The postbiotic drug prepared by the present application has high safety and good stability, and can be applied to the preparation of drugs for preventing and / or treating osteoarthritis; the postbiotic drug can also be used to promote bone health, enhance the antioxidant capacity of osteoblasts and / or chondrocytes, promote osteoblast activity and / or promote calcium absorption and fixation, and provides a new solution for joint health management.

The present application belongs to the field of intelligent medical treatment and digital health technology, and provides a bone health state personalized tracking and risk prompting system, which comprises a data sensing layer, a feature fusion layer, an intelligent decision-making layer and an interactive application layer connected in sequence. The data sensing layer collects PPG signals, motion signals and structured health data of users through intelligent wearable devices. The feature fusion layer extracts western medicine physiological feature sequences, traditional Chinese medicine Zangxiang feature vectors and lifestyle feature vectors. The intelligent decision-making layer adopts a double-track driving mechanism of personal dynamic baseline tracking and traditional Chinese and western medicine fusion feature analysis. Early warning and personalized intervention schemes are distributed in the interactive application layer, forming a closed loop of monitoring, evaluation, prompting, intervention and re-evaluation. The present application realizes long-term, dynamic and non-invasive continuous tracking and prospective risk prompting of bone health state, and solves the pain points of traditional imaging examination, such as staticity, fragmentation and inability to be integrated into daily management.

This invention belongs to the field of nutritional composition technology, specifically relating to a composition, composition formulation, preparation method, application, and product for improving bone health. This invention provides a composition composed of N-acetylglucosamine and 3-O-acetyl-11-keto-β-boswellic acid. The composition and formulation of this invention can promote the differentiation of chondrocyte precursor cells into mature chondrocytes, promote cartilage matrix synthesis, significantly inhibit TNF-α and MMP13 expression, and upregulate COL2A1 expression, with effects superior to single components and traditional combinations. The ingredients are natural and safe, biocompatible, and have no significant toxicity, making them suitable for people with joint noise, joint pain, osteoarthritis, and joint degeneration. Simultaneously, they can improve bone density, promote bone growth and development, and improve bone health. The preparation process is simple and low-cost, and it can be formulated into various dosage forms such as food, health products, and pharmaceuticals, offering flexible applications and combining preventative and therapeutic value.

The objective is to provide information on the use of mangosteen peel extract in the preparation of compositions for maintaining bone health. [Solution] Mangosteen peel extract is obtained by sequentially extracting the fruit peel of mangosteen (Garcinia mangostana) in two stages using an enzyme solution at different extraction temperatures. This two-stage extraction completely releases and retains the active ingredients in the mangosteen peel, increasing the active ingredient content in the extract. As a result, a variety of functions related to bone health can be expected, such as bone strengthening, prevention of joint wear, suppression of bone loss, improvement of bone density, promotion of calcium absorption, alleviation of inflammation in the body, and prevention of inflammation caused by joint wear.