86 results about "Bone health" patented technology

The invention belongs to the technical field of microbial fermentation, and particularly relates to lactobacillus rhamnosus capable of maintaining bone health and improving local joint inflammation and a metagen and application of the lactobacillus rhamnosus. According to the invention, the probiotic NKU ML1-2 is subjected to fermentation culture, such that a post-generation product is prepared. Results of embodiments prove that the metagen product can enhance the oxidation resistance of cartilage and osteoblasts and promote the synthesis of anti-inflammatory factors and cartilage matrixes (type II collagen and proteoglycan), and has the potential of relieving oxidative stress and inflammatory response of local joints, relieving joint inflammation and delaying cartilage destruction. The prepared metagen product is high in safety and good in stability, and can be applied to preparation of medicines for preventing and / or treating osteoarthritis; the metagen product can also be used for promoting bone health, enhancing the antioxidant capacity of osteoblasts and / or chondrocytes, promoting osteoblast activity and / or promoting calcium absorption and fixation, and a new solution is provided for joint health management.

The invention belongs to the technical field of biological medicine, and discloses a probiotic agent capable of improving the physiological activity function of vitamin D and maintaining bone health and application of the probiotic agent. The invention provides a probiotic agent composed of bifidobacterium adolescentis and bifidobacterium longum, the probiotic agent can significantly improve the bone mineral density, the bone trabecula thickness, the bone trabecula number, the bone trabecula connectivity and the bone volume fraction of an osteoporosis mouse, and meanwhile, the bone trabecula separation degree of the osteoporosis-removed mouse is significantly reduced; the level of vitamin D metabolites such as 25-hydroxy vitamin D and 1, 25-dihydroxy vitamin D in mouse serum is improved; the content of serum calcium and alkaline phosphatase in serum of mice is reduced, and the level of osteocalcin and type I procollagen amino terminal peptide in the serum is improved. The probiotic agent can relieve bone calcium loss, maintain bone health, repair bone injury, increase osteoblasts and reduce the osteoporosis degree, and can be used for preparing drugs for preventing and / or treating osteoporosis or preparing health care products or food beneficial to improving bone mineral density.

The embodiment of the invention discloses a skeleton health dynamic tracking and intervention method and system based on movement and nutrition. The method comprises the following steps: acquiring gait information, bone metabolite information and bone state measurement parameters of a target user by adopting wearable equipment; processing the gait information, the bone metabolite information and the bone state measurement parameters based on an artificial intelligence (AI) model to obtain bone state prediction parameters; according to the bone state prediction parameter and the health data of the target user, performing bone health state evaluation of the target user to obtain a health state prediction parameter; the health state prediction parameters comprise a bone health state instant evaluation index and bone health dynamic trend data; generating a targeted exercise plan and a diet plan according to the health state prediction parameters; wherein the target motion planning is used for guiding the motion of the target user; the diet planning is used for guiding the diet of the target user.

The invention discloses an alveolar bone noninvasive detection method based on a spatial offset Raman spectrum technology. The method comprises the following steps: S1, selecting a first near-infrared excitation wavelength and a second near-infrared excitation wavelength to form a multi-wavelength tunable excitation light beam; s2, synchronously acquiring a first group of original Raman spectrum signals under a plurality of spatial offset distances; s3, acquiring a second group of original Raman spectrum signals by using an acousto-optic composite modulation Raman enhancement mechanism; s4, inputting the soft tissue optical parameter set into a joint inversion equation; s5, obtaining a deep alveolar bone Raman characteristic spectrum data set; s6, training an alveolar bone tissue health recognition model; and S7, based on the alveolar bone tissue health recognition model, performing health state judgment on the deep alveolar bone Raman characteristic spectrum data set acquired in real time, and generating an alveolar bone health assessment result. The early screening and dynamic monitoring capabilities of alveolar bone diseases are greatly improved, and the clinical working efficiency of doctors and the doctor-seeing experience of patients are remarkably optimized.

The invention discloses a composition for improving bone density and application thereof, and belongs to the technical field of food. According to the invention, the 1, 3-dioleic acid-2-palmitin, the osteopontin and the oligosaccharide are compounded for use, and the components interact to promote mutual absorption and utilization, so that the growth and development of bones in the growth period of infants are improved, the mineral content and the bone mineral density of the bones are increased, the health of the bones is promoted, and the composition is safe and free of side effects. And by optimizing the variety of the oligosaccharide, the compound use of the galactooligosaccharide and the 2 '-fucosyllactose is found to be capable of better improving the growth and development of bones in the growth period of the infants.

The invention provides a composition for promoting bone health and bone formation as well as application and a product thereof, and belongs to the field of foods. The composition disclosed by the invention is prepared from the following components in parts by weight: 1 to 5 parts of osteopontin, 1 to 50 parts of 2 '-fucosyllactose and 0.05 to 50 parts of a calcium source. The composition disclosed by the invention shows a relatively good synergistic effect in promoting calcium absorption, and can be used for improving bone density, preventing and treating osteoporosis and the like.

The invention discloses a lactobacillus rhamnosus capable of improving joint inflammation and promoting bone health, a metagen and application of the lactobacillus rhamnosus, the lactobacillus rhamnosus is lactobacillus rhamnosus BN02, the lactobacillus rhamnosus is preserved in China General Microbiological Culture Collection Center on November 27, 2023, and the preservation number is CGMCC No.29133. The lactobacillus rhamnosus can be used for improving joint inflammation and promoting bone health. The lactobacillus rhamnosus BN02 can reduce the number of gram-negative bacteria in intestinal tracts of arthritis patients, increase the synthesis amount of bone collagen, and is beneficial to promoting absorption of vitamin C by the intestinal tracts, improving joint inflammation and promoting bone health.

The invention belongs to the technical field of biology, and particularly relates to casein phosphopeptides for promoting absorption of calcium, iron and zinc minerals and improving bone health. Casein phosphopeptides containing high-activity peptide fragments are obtained through an optimization process, six mineral elements of calcium, magnesium, copper, iron, zinc and manganese serve as research objects, firstly, mineral utilization of CPP is evaluated through a mineral deficiency rat model, the content of Ca, Mg, Cu, Fe, Zn and Mn in thighbones is increased by 7.12%, 3.56%, 20.76%, 15.84%, 9.94% and 67.12% respectively when the CPP is eaten by 7mg / kg.d; secondly, screening a peptide fragment with calcium absorption promoting activity from the CPP by utilizing a molecular docking technology, and performing functional verification; the invention aims to reveal the action effect of CPP in mineral absorption and utilization from cell and animal levels, and provides a theoretical basis for functional development of CPP.

The invention discloses an orthopedic science popularization recommendation system based on smart health, and belongs to the technical field of smart health. Through the immersive interaction module, the user can check and interact in the virtual environment, the health state of the bone and the influence of movement on the bone are known in real time, through dynamic display of the personalized bone model, the user can more visually understand the bone health of the user, and the user experience is improved. The intelligent recommendation module identifies interest points and health requirements of the user by collecting behavior data of the user in the immersive interaction module, pushes personalized orthopedic knowledge content based on the interest points and the health requirements, and helps the user to obtain targeted health suggestions and popular science knowledge, so that the accuracy and effectiveness of health management are improved, and the user experience is improved. The health awareness and long-term attention of the user are improved by enhancing the sense of participation and the education effect of the user, and the user is ensured to obtain health knowledge most relevant to the own condition by analyzing the behavior data and the health condition of the user and pushing the content matched with the health requirement of the user.

The invention relates to the technical field of medical information, in particular to an osteoporosis risk intelligent early warning method and system based on a big database. The method comprises the following steps: extracting user bone health data in a multi-source health database; evaluating a bone mass state based on the user bone health data; screening osteoporosis risk users in the user bone health data according to the bone mass state; inquiring a medical image of the osteoporosis risk user; extracting a bone mineral density value by using the medical image, and determining a bone mineral density change trend according to the bone mineral density value; detecting the degeneration degree of the bone microstructure by using a medical image; constructing an osteoporosis risk early warning model according to the bone mineral density change trend and the bone microstructure degeneration degree; and inputting the user bone health data into the osteoporosis risk early warning model to generate a risk early warning score. According to the invention, accurate identification and dynamic monitoring of the osteoporosis risk user are realized based on the medical information technology, and the accuracy and response rate of osteoporosis risk early warning are improved.

The invention discloses a composition for promoting skeletal growth and physical development of children and a preparation method, the composition comprises a plurality of nutrient elements and Chinese herbal medicine components, and the components have the effects of promoting skeletal health, enhancing immunity, improving nutrient absorption, regulating metabolism, improving sleep quality, promoting secretion of growth hormone and the like. The healthy growth of bones and the overall development of a body are jointly promoted.

The invention relates to the technical field of osteoporosis patient auxiliary exercise, and discloses an osteoporosis-based self-adaptive patient auxiliary exercise device which comprises a bottom plate, an adjusting mechanism is arranged at the top of the bottom plate, a detection mechanism is arranged outside the adjusting mechanism, a positioning block is fixedly connected to the top of the bottom plate, and the positioning block is fixedly connected to the bottom plate. Two massage mechanisms are arranged outside the positioning block, a training mechanism is arranged at the top of each massage mechanism, and a buffer mechanism is arranged at the top of the positioning block; the massage mechanism comprises a supporting rod, the outer portion of the supporting rod is fixedly connected to the inner wall of the positioning block, and a third electric guide rail is installed in the supporting rod. The connecting rotating rod is driven by the motor to rotate, the connecting block and the massage wheel are driven, the legs of a patient are massaged and stimulated through the surface acting force of the massage wheel, blood circulation and muscle relaxation are promoted, and the leg skeleton health exercise system is matched, so that the leg muscle strength is improved, skeleton generation is stimulated, and the osteoporosis process is slowed down.

The invention discloses bifidobacterium longum subsp.longum capable of improving the physiological activity function of vitamin D and maintaining bone health and application of the bifidobacterium longum subsp.longum, and belongs to the technical field of biological medicine. The bifidobacterium longum subsp. Longum CCFM1448 provided by the invention can obviously improve the total bone mineral density, the bone mineral density of distal femur bone trabecula, the thickness of the bone trabecula, the number of the bone trabecula, the connectivity of the bone trabecula and the bone volume fraction of an osteoporosis mouse, and obviously reduce the separation degree of the bone trabecula of the osteoporosis mouse; the content of a vitamin D metabolite 1, 25-dihydroxy vitamin D in serum of a mouse with osteoporosis is remarkably increased, the content of serum calcium and alkaline phosphatase in the serum of the mouse with osteoporosis is reduced, and the level of osteocalcin and I-type procollagen amino-terminal original peptide in the serum is increased. Therefore, the bifidobacterium longum subsp. Longum CCFM1448 has the effects of relieving bone calcium loss, maintaining bone health, repairing bone injury, increasing osteoblasts and reducing osteoporosis degree.

The invention relates to an application of plant lactobacillus Hi188 in promotion of bone health. The invention provides the application of the plant lactobacillus Hi188 or the afterbiogen thereof or the composition thereof in increasing the bone mineral density, increasing the bone mineral density, promoting the skeletal development, increasing the bone mineral content and / or promoting the tibia growth. Or preparing food for increasing bone mineral density, increasing bone mineral density, promoting skeletal development, increasing bone mineral content and / or promoting tibia growth; wherein the composition comprises: (A) Phytobacterium plantarum Hi188 or a postbiotic thereof, and (B) Bifidobacterium lactis Ca360 or a postbiotic thereof.

The invention discloses application of bifidobacterium longum subsp. Longum i772 in a product for promoting bone health, and belongs to the field of microbial engineering. The effective components of the product for promoting bone health comprise live bifidobacterium longum subsp. Longum i772 and / or inactivated bifidobacterium longum subsp. Longum i772. The product provided by the invention can effectively promote bone health no matter whether the product contains viable bacteria or inactivated bacteria, and experimental data shows that the probiotic agent containing the bifidobacterium longum subsp. Longum i772 can significantly improve the bone density, bone volume fraction and bone trabecula thickness in a female rat osteoporosis model, and has a good application prospect. The bone trabecula spacing in the female rat osteoporosis model is reduced; meanwhile, the strain has an intestinal colonization effect and can continuously play a role in promoting bone health in the intestinal tract, and the trouble of daily medication can be reduced. The food provided by the invention is suitable for promoting bone health and preventing and / or improving osteoporosis.

The application discloses a functional composition for improving bone and joint health, a conditioner and application. The functional composition comprises a first active component and a second active component; the first active component comprises elastin peptide, haematococcus pluvialis and ergothioneine; and the second active component comprises one or more of houttuynia cordata and non-denatured type II collagen. The application realizes the protection effect on joint, cartilage and bone health by scientific matching of the components and synergistically improving the glycosaminoglycan level in chondrocytes and the osteocalcin level in osteoblasts. Meanwhile, the components in the functional composition for improving bone and joint health are natural and have good biocompatibility, and have no obvious side effects, so that the application provides a kind of drug or a substitute for the treatment and prevention of bone diseases.

The application discloses a multi-source bone density data fusion method, system and storage medium, and belongs to the field of medical big data and intelligent diagnosis. The method aims at the systematic deviation between DXA devices of different manufacturers and the high detection uncertainty problem under the primary medical environment. Firstly, the multi-source bone density data and the corresponding physical calibration parameters are projected to a unified measurement space through standardized preprocessing and device-related mapping functions, and the device barriers are eliminated by using distribution alignment constraints. Then, Gaussian uncertainty modeling is performed on the projected data to quantify the influence of specific clinical factors on measurement reliability. Based on the uncertainty propagation mechanism, the multi-source discrete evidence is adaptively compensated and fused by weight, and multi-dimensional features including physiology, medical history and anatomical topology are introduced for joint modeling. Finally, end-to-end optimization is performed through a joint function of fusion uncertainty constraint and task loss, and high-robustness osteoporosis risk intelligent evaluation is realized. The application significantly improves the consistency of cross-device T value prediction and the accuracy of missed diagnosis / misdiagnosis review, and is suitable for multi-center bone density mutual recognition and primary medical bone health intelligent evaluation scene.

The present invention discloses a measurement and judgment method for orthopedic diagnosis, which belongs to the technical field of orthopedic diagnosis and treatment, comprising: collecting magnetic field signals of bone metabolism through a magnetic field sensor array, collecting electrical impedance spectroscopy data through a four-electrode method to form an original data set; filtering and denoising the magnetic field signals and correcting motion artifacts, and then fitting the electrical impedance spectroscopy data with a Cole-Cole model to extract bone density, porosity, and moisture content; calculating bone metabolic current density through a magnetic field-current inversion algorithm, combining electrical impedance characteristics and current characteristics, and generating a bone health index through a dynamic weight distribution mechanism; by combining the magnetic field-current inversion algorithm with Cole-Cole model analysis, multi-dimensional information of bone metabolic activity and bone tissue structure can be simultaneously obtained, thereby effectively overcoming the problem of insufficient information from a single physical field and significantly improving the accuracy of diagnosis.

A method and system for analysis of medical images is presented in the field of analysis of medical images. The method and systems is provided to determine one or more parameters of bones in medical images. The method and system may be characterized as an advancement in analysis of medical images to ascertain bone health and discern pathologies in bone. Specifically, a system and method is disclosed for analysing medical images showing at least a portion of a bone to determine one or more bone parameters for the at least one portion of a bone. Steps taken by the system and method include: determining a region of interest of the medical image; identifying a boundary of at least one of an inner edge and an outer edge of cortical bone of the at least one portion of the bone within the region of interest; identifying at least one boundary of trabecular bone of the at least one portion of the bone within the region of interest; utilising the identified boundaries to determine at least one of the following bone parameters: orientation, bone mineral density, length, width of trabecular structure, for the at least one portion of bone within the region of interest.

The application discloses a composition for improving bone density and application thereof, and belongs to the technical field of food. The composition is prepared by using 1,3-dioleic acid-2-palmitic acid triglyceride, osteonectin and oligosaccharide in combination, and through the interaction between the components, the absorption and utilization of each other are promoted, the growth and development of the bone of an infant in the growth period are improved, the bone mineral content and bone density are improved, the bone health is promoted, and the composition is safe and has no side effect. Through optimization of the types of the oligosaccharide, it is found that the combination of oligogalactose and 2'-fucosyllactose can better improve the growth and development of the bone of the infant in the growth period.

The invention provides a bone evaluation method based on neural network enhancement and finite element analysis. The bone evaluation method comprises the following steps: acquiring an ultrahigh-resolution CT image of a living vertebra; performing domain conversion processing on the CT image by adopting a generative neural network; carrying out resampling and segmentation on the enhanced CT image; constructing a bone trabecula microstructure model in the cancellous bone mask area; assembling the RVE unit and the cortical bone model into a complete vertebral finite element model, and applying a multi-working-condition load to the RVE unit to calculate anisotropic material parameters; and carrying out axial compression finite element analysis on the complete centrum model, and judging the bone health state. According to the method, information of two dimensions of bone mass and bone, especially contribution of a bone trabecula microstructure to bone strength, is comprehensively considered, bone degeneration and fracture high-risk patients can be recognized earlier, and a scientific basis is provided for clinical early intervention.

Described herein are compositions for maintaining and / or improving bone health in a subject (e.g., an aging subject) comprising N 1 - dihydrocaffeoyl-N 10 - caffeoyl spermidine and an additive. Further, described herein are methods for maintaining and / or improving bone health in a subject (e.g., an aging subject). Further, described herein are methods for preventing and / or treating bone disease in a subject (e.g., an aging subject).

The present invention relates to the use of a composition comprising an effective amount of a combination of fesoterodine and / or a derivative thereof and quercetin and / or a derivative for preventing or treating a bone disorder or maintaining bone health in an individual.

The invention discloses a functional composition capable of improving bone and joint health, a conditioner and application. The functional composition comprises a first active component and a second active component, the first active component is prepared from elastin peptide, haematococcus pluvialis and ergothioneine; the second active component is prepared from one or more of herba houttuyniae and non-denatured type II collagen. Through scientific compatibility of all the components, the levels of glycosaminoglycan in chondrocytes and osteocalcin in osteoblasts are synergistically improved, and the protection effect on joint, cartilage and skeleton health is achieved. Meanwhile, a plurality of components in the functional composition capable of improving the health of the bones and the joints are natural in source, good in biocompatibility and free of obvious side effects, and a medicine or an alternative scheme thereof is provided for treatment and prevention of the bone diseases.

The application belongs to the technical field of biology and specifically relates to a casein phosphopeptide for promoting calcium, iron and zinc mineral absorption and improving bone health. The application obtains the casein phosphopeptide containing high-activity peptide segments by optimizing the process, and takes six mineral elements of calcium, magnesium, copper, iron, zinc and manganese as research objects. Firstly, the mineral deficiency rat model is used to evaluate the mineral utilization of the CPP. The consumption of 7mg / kg.d increases the contents of Ca, Mg, Cu, Fe, Zn and Mn in femur by 7.12%, 3.56%, 20.76%, 15.84%, 9.94% and 67.12% respectively. Secondly, the molecular docking technology is used to screen the peptide segments with calcium absorption activity from the CPP and perform function verification. The application aims to reveal the effect of the CPP in the mineral absorption and utilization from the cell and animal levels, and provide a theoretical basis for the functional development.

A system and method are disclosed to estimate bone health wherein a cross-sectional shape of cortical bone is segmented and parameterised and regions of internal bone extracted. Typically, two regions of internal bone structure are extracted and quantified (cortical and trabecular), or three regions of internal bone structure are extracted and quantified (cortical, endocortical and trabecular). Metrics including, but not limited to, absolute volume, relative volume, volumetric bone mineral density (BMD) and areal bone mineral density (BMD) are measured from the extracted regions. The system and method accurately estimate bone health as an incidental finding from standard imaging procedures. It is robust to several imaging acquisition techniques.

This utility model discloses a quantitative dispensing container for formulated milk powder for bone health in middle-aged and elderly people. It includes a mixing tank, a cover plate fixedly installed on the top of the mixing tank, an outer shell fixedly installed on the top of the cover plate, and a mounting plate rotatably connected to the inner top of the outer shell. A discharge pipe is fixedly installed on the left end of the top of the cover plate, and a baffle is sleeved and connected to the outside of the discharge pipe. A rotating component is located at the middle position of the top of the cover plate, and an adjusting component is located on the left end of the top of the cover plate. The discharge component is mounted on the mounting plate. This quantitative dispensing container for formulated milk powder for bone health in middle-aged and elderly people can effectively control the intake through the rotation of the discharge baffle, reducing the risk of insufficient or excessive intake, thereby ensuring the acquisition of appropriate nutrients. Furthermore, the shielding of the lower end of the hopper effectively prevents the milk from contacting air and also effectively prevents accidental powder leakage or splashing.

This invention discloses a composition with bone-health-promoting functions and its applications, belonging to the field of microbial engineering. The composition comprises milk calcium, colostrum basic protein, and Bifidobacterium breve i1088 powder. The composition provided by this invention, which has a synergistic effect between milk calcium, colostrum basic protein, and Bifidobacterium breve i1088 powder, enhances the conversion rate of calcium from the blood to bone through the action of probiotics, thereby improving the actual utilization rate of calcium and effectively promoting bone health. Experimental data show that this composition significantly increases bone mineral density, bone volume fraction, and trabecular thickness in a female rat osteoporosis model, and significantly reduces trabecular spacing in the same model. The composition provided by this invention is suitable for promoting bone health and preventing and / or improving osteoporosis.

The present invention relates to use of a composition comprising an effective amount of a combination of fisetin and / or derivative thereof and quercetin and / or derivative for for use to prevent or treat bone disorders or maintenance of bone health in an individual.

The application provides a composition for promoting bone health and bone formation, and application and products thereof, and belongs to the field of food. The composition of the application is composed of 2'-fucosyllactose, osteopontin and a calcium source, wherein the osteopontin is 1-5 parts, the 2'-fucosyllactose is 1-50 parts and the calcium source is 0.05-50 parts by weight. The composition of the application shows a good synergistic effect in promoting calcium absorption, and can be used for increasing bone density, preventing and treating osteoporosis and the like.