75 results about "Ageing" patented technology

The present invention provides information comprising at least one GSK-3 activator for use in the prevention and / or treatment of aging and aging-related conditions and diseases by increasing proteasome activity.

The invention provides a simulated aging test method for an antifouling coating. The simulated aging test method comprises the following steps: S1, constructing a natural aging performance model of the antifouling coating; s2, constructing an accelerated aging model of the antifouling coating and acquiring an acceleration ratio N of natural aging to accelerated aging; s3, based on an accelerated aging model, acquiring an acceleration period Mi corresponding to a critical threshold R (temporary i) of a copper ion exudation rate, wherein the predicted life Lp (temporary i) of the antifouling coating is equal to Mi * N; and S4, based on a natural aging model, obtaining a predicted copper ion exudation rate R < pre-i > corresponding to the predicted life Lp < pre->, judging whether R < pre-i >-R < critical i > / R < critical i > is less than or equal to 10%, if so, outputting a near threshold R < critical i > and the predicted life Lp < pre-i >, and if not, adjusting the critical threshold of the copper ion exudation rate to R < critical i + 1 > and returning to the step S3. According to the method, the performance failure threshold value of the antifouling coating is taken as a boundary condition, the performance of the antifouling coating is rapidly evaluated, the service life of the antifouling coating is quantitatively predicted, the prediction result is subjected to cooperative cross validation through linkage double models, and the reliability is improved.

The invention relates to a P91 pipeline aging prediction method, and belongs to the field of P91 pipeline aging prediction. The method comprises the following steps: acquiring a micro-magnetic signal (such as Barkhausen noise) of a P91 pipeline through a micro-magnetic detector, and extracting characteristic parameters related to an aging state; and inputting the parameters into a pre-trained aging grade prediction model, and directly outputting the aging grade (1-5 grade) of the pipeline. The prediction model is constructed based on a machine learning algorithm (such as ReliefF feature selection and a BP neural network), and training data comes from an accelerated aging sample which is simulated through specific heat treatment and has a clear microstructure (represented by EBSD) and macromechanical property correlation. According to the method, rapid, lossless and quantitative prediction of the aging state of the P91 pipeline is realized, and a reliable basis is provided for safety assessment and residual life prediction of the in-service pipeline.

The invention relates to the technical field of rubber materials, and relates to a rubber multi-stress aging life prediction method based on an Eyring model and a PSO algorithm, and the method comprises the steps of multi-stress aging experiment data collection, single degradation track curve modeling, reference condition and acceleration factor definition, Eyring model establishment and parameter identification, and extrapolation of life under natural use conditions. According to the method, the stability of parameter estimation is remarkably improved by introducing a two-stage parameter identification method, a parameter initial value is obtained through individual curve fitting, then a shape parameter alpha and a position parameter gamma are fixed, a rate parameter beta is identified again, and the parameter standard deviation can be reduced; the ratio of the reaction rates is introduced as an acceleration factor for parameter identification instead of directly identifying the reaction rates, so that the dimensional influence and experimental system errors are effectively eliminated, data of different batches of materials under different experimental conditions have comparability, and the engineering applicability of the model is remarkably improved; the PSO algorithm is adopted to carry out global parameter optimization, so that the prediction precision and the calculation efficiency can be effectively improved.

The invention discloses a plant lactobacillus with light aging resistance and an application thereof. The preservation number of the plant lactobacillus cj001 disclosed by the invention is CGMCC (China General Microbiological Culture Collection Center) No.35419. The fermentation supernatant of the plant lactobacillus cj001 shows good anti-aging activity and in-vitro antioxidant activity, and the growth ability of HaCaT cells is promoted. After the combined fermentation product of the plant lactobacillus cj001 and the lactobacillus paracasei Grx701 is subjected to ultraviolet radiation, the proliferation of HaCaT cells can be promoted, the endogenous antioxidant capacity of human skin cells can be enhanced, the photooxidation damage can be effectively relieved, and the combined fermentation product has a wide application value in the field of preparation of products with antioxidant, anti-aging, anti-ultraviolet damage, anti-photoaging and the like.

Described herein are compositions and methods for performing plasmapheresis. The compositions and methods for performing plasmapheresis are innovative at least in their application towards the treatment and prevention of aging and conditions associated with aging. Plasmapheresis compositions and methods described herein are directed towards reducing or eliminating conditions associated with aging.

The present invention relates to a medium composition for in vitro fertilization and / or in vitro culture comprising a compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof, and a method using same. The compound or composition suppresses reactive oxygen species and lipid peroxidation in ovarian granulosa cells to preventing cytotoxicity and mitochondrial dysfunction caused by apoptosis and ferroptosis, leading to an improvement in the quality of aged oocytes, and to increase the developmental rate and blastocyst formation rate of pre-implantation embryos, thereby improving the efficiency of in vitro fertilization. In addition, treatment with the medium composition during the vitrification process of in vitro–fertilized embryos improves re-expansion and survival rates, thereby reducing structural and metabolic damage. Accordingly, the present invention can be advantageously applied to an assisted reproductive technology for treating infertility and subfertility, and in vitro fertilization and / or in vitro culture for improving the propagation efficiency of livestock.

The application belongs to the technical field of genetic engineering, and particularly relates to a citrate synthase gene AtCS The application relates to the application of a citrate synthase gene in regulating the anti-aging ability of seeds and a method for screening seed anti-aging agents. AtCS The application provides a citrate synthase gene AtCS The nucleotide sequence of the citrate synthase gene is shown as SEQ ID NO. 1. The citrate synthase gene AtCS (referred to as AtCS gene) encodes a citrate synthase located in mitochondria. AtCS The gene plays a key role in regulating the active oxygen homeostasis and anti-aging ability of seeds. AtCS The germination rate of the seed of the gene knockout mutant significantly decreases after aging, membrane lipid peroxidation products accumulate, and the active oxygen scavenging system is damaged. The mutant can be used for screening seed anti-aging agents, and provides a new solution for seed anti-aging.

The utility model discloses an aging auxiliary device for biochar. The aging auxiliary device comprises a treatment box body, a material frame, a temperature control mechanism, a humidity control mechanism and a stirring mechanism, after being opened, the top of the treatment box body is sealed by a box cover; the material frame is detachably installed in the treatment box body, and after charcoal needing to be aged is placed in the material frame, the charcoal is stirred through the stirring mechanism in the material frame; the temperature control mechanism is arranged in the treatment box body and is used for controlling the temperature around the material frame and providing the required temperature for aging; and the humidity control mechanism is arranged in the treatment box body and is used for controlling the humidity around the material frame and providing the required humidity for aging. Compared with the prior art, the aging device has the advantages that the temperature control mechanism and the humidity control mechanism are arranged, so that the temperature and the humidity in the aging environment are accurately adjusted, the aging environment under natural conditions or specific application scenes is simulated, and the aging efficiency is improved while the quality is ensured.

Integrated platforms, systems, and associated processes for measuring lifespan, body size and shape, activity, pathology, pigmentation / color, and multiple in vivo molecular biomarkers using multiple cameras are described. The integrated platform includes a plate and trays supported on the plate. Each tray can hold animals. The integrated platform also includes an imaging module with a first camera and a second camera. The first camera can capture first images associated with movement of the animals and the second camera can capture second images and third images associated with biomarkers of the animals.

Provided herein are methods that use methylation of causal CpG sites to quantify aging and predict whether an intervention will be protective or damaging to the aging process.

The invention discloses a precise positioning method for key decline nodes of aging activity of rice seeds, and belongs to the technical field of agricultural science. The method specifically comprises the following steps: (1) performing continuous different-time-length artificial accelerated aging treatment on rice seeds with the same batch and the same activity level; (2) seed soaking and germination accelerating treatment; (3) indoor normal germination test; (4) measuring seed vigor indexes; (5) statistical comparison; and (6) defining the number of aging days corresponding to the first time when statistical significant decline occurs as the aging activity key decline node of the rice seed. According to the method, by simulating natural aging conditions, the nodes (namely critical points) of key decline of the activity of the rice seeds in the artificial accelerated aging process can be accurately positioned. According to the method, the mutation inflection point of the seed activity under the high-strength aging condition is quantified for the first time, and an accurate and reliable technical standard is provided for seed aging mechanism research, activity early warning and storability evaluation.

Combination therapies comprising oxytocin and gonadotropin releasing hormone are provided. The combinations can be used to treat aging-related neurological diseases or disorders. In addition, downstream effectors of OXT-GnRH combination, including hypothalamic stem / progenitor cells-derived EVs and vesicles containing or loaded with PTMS, can be used to treat aging-related neurological diseases or disorders.

The present invention relates to a Grateloupia turuturu red algae extract and a cosmetic composition comprising thereof. The present invention also relates to a process for preparing a Grateloupia turuturu red algae extract by aqueous hot extraction. The present invention also relates to the use of said Grateloupia turuturu red algae extract as a cosmetic active ingredient, in particular as a slow-ageing agent.

The invention discloses a neural network-driven natural ester aging degree evaluation method and system, and the method comprises the steps: S1, collecting and preprocessing near infrared spectrum data, working condition time sequence data and physicochemical index data of transformer natural ester; S2, constructing a working condition perception convolutional neural network, and extracting working condition time sequence statistical characteristics and spectrum-working condition mixed characteristics; calculating a working condition interference adaptive gating weight and a preliminary aging feature; introducing an aging characteristic consistency constraint function, calculating constrained aging characteristics, and finally extracting natural ester aging characteristics without working condition interference; s3, extracting multi-source preliminary fusion features; constructing a multi-index dynamic coupling attention mechanism, calculating a multi-index coupling feature, and then calculating an overall aging state feature of the natural ester; s4, aging classification features are calculated, and aging grade judgment is completed. The method can solve the problem of inaccurate evaluation of the aging degree of the natural ester caused by transformer load fluctuation and environment temperature change in a traditional method.

The invention relates to a method for evaluating aging and, in particular, for monitoring the condition of an electrical device (1) comprising a fixed insulation system (I) and a liquid and / or gaseous insulating medium (13) in contact with said system (I). In this method, a thermohydraulic aging model (16) is provided, and a simulation of the electrical device (1) is performed. Local temperatures (T1-T5) are calculated for different areas of the electrical device within the simulation, and the quantities of at least one aging product, which forms due to the aging of the fixed insulation system (I) and passes into the insulating medium (13), are calculated for the different areas (8a-8f). Furthermore, the invention relates to a computer program and a computer-readable storage medium.

This invention provides the application of *Ackermania guangxiensis* extracellular polysaccharide in the preparation of anti-aging products, belonging to the technical field of microbial polysaccharide pharmaceutical applications. This invention extracts extracellular polysaccharides from *Ackermania guangxiensis* using the TCA precipitation method. Animal experiments show that *Ackermania guangxiensis* extracellular polysaccharide can effectively reduce MDA content in aging model mice while increasing SOD activity; it improves the thinning of the dermal layer, reduction and loosening of collagen fibers, and other signs of aging in model mice, and increases the hydroxyproline content in the skin; furthermore, it can activate the expression of BDNF and TrKB genes in the mouse hippocampus and alleviate problems such as slow movement, cognitive impairment, and memory decline in model mice. Therefore, the *Ackermania guangxiensis* extracellular polysaccharide provided by this invention has good anti-aging and antioxidant activity and can be used to prepare various anti-aging products.

The application discloses a material performance evolution trend prediction method and device and a storage medium, relates to the technical field of material science, and mainly aims at improving the determination efficiency and accuracy of the material performance evolution trend. The method comprises the following steps: in response to a material performance evolution trend prediction signal of a target material in an aging process, obtaining aging environment information of the target material and historical material performance of a previous aging time point corresponding to a current aging time point; taking the current aging time point and a plurality of future aging time points as to-be-predicted time points, inputting the historical material performance and the aging environment information into a preset performance prediction model to gradually perform material performance recursive prediction of each to-be-predicted time point, and sequentially obtaining material performance of each to-be-predicted time point; and determining the material performance evolution trend of the target material in the aging process based on the historical material performance and the material performance of each to-be-predicted time point.

The invention is concerned with the cosmetic use of a composition comprising an extract of Saccharomyces cerevisiae for modulating exosome content, thereby preventing aging and / or senescence, in particular intrinsic and / or extrinsic dermal aging.

The application belongs to the field of agricultural microorganism technology, and particularly relates to a bacillus velezensis with double effects of disease resistance and growth promotion and application thereof. The strain number is BVZX-1. The bacillus velezensis BVZX-1 strain has been preserved in the China General Microbiological Culture Collection Center, the preservation date is November 7, 2025, the preservation address is No. 1, Xili, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC No. 36546. The bacillus velezensis BVZX-1 has effects of disease resistance, growth promotion, seed germination promotion and seed aging delay.

A computer-implemented method for identifying the ageing test conditions for accelerated ageing tests of a product, wherein the method comprises: obtaining at least one parameter of the product; perfo

Provided is a novel pharmaceutical composition for treating or preventing an aging-related disease by utilizing selective removal of a senescent cell. A pharmaceutical composition comprising an anti-integrin α11 (ITGA11) antibody as an active ingredient is administered to a subject.

This invention discloses a method, device, system, and storage medium for predicting the thermo-oxidative aging performance of polyamide, including: acquiring experimental data of polyamide thermo-oxidative aging under various coupled conditions such as oxygen pressure, temperature, and sample thickness, and the corresponding tensile strength retention rate; constructing a modified response prediction closed-form formula based on the diffusion-reaction synergistic mechanism and introducing it as a soft physics constraint into the model; employing a multi-objective joint training strategy to simultaneously minimize data fitting error and physical equation residuals; evaluating and visualizing the performance of the trained model, solving for and outputting the model parameters. Using the technical solution of this invention, PINN driven by the reaction-diffusion synergistic closed-form formula is used to predict the thermo-oxidative aging performance of polyamide under multiple coupled conditions.

The invention provides a biological age prediction correction method and system based on individual differences, relates to the field of artificial intelligence, and solves the technical problems of systematic prediction deviation, missing of individual difference modeling and insufficient clinical interpretability caused by the fact that a biological age prediction model only depends on a time age label and a statistical loss function in the prior art. The method comprises the following steps: acquiring multi-modal physiological data and corresponding time and age of a plurality of healthy individual samples; predicting an initial biological age prediction value of the individual sample based on the physiological data; and based on the time age of the individual sample and the corresponding initial biological age prediction value, fitting to obtain an average biological age prediction function, calculating an aging difference value of the individual sample relative to the same-age group, further constructing a composite loss function, and training the biological age prediction model by minimizing the composite loss function to obtain a biological age prediction result. And obtaining a biological age prediction correction model. The method is used in the biological age prediction correction process.

Described herein are compositions and methods for performing plasmapheresis. The compositions and methods for performing plasmapheresis are innovative at least in their application towards the treatment and prevention of aging and conditions associated with aging. Plasmapheresis compositions and methods described herein are directed towards reducing or eliminating conditions associated with aging.

The present invention relates to a method for preparing an extract of at least one bacterium of the species Staphylococcus epidermidis comprising at least one step of culturing at least one bacterium of the species Staphylococcus epidermidis in the presence of a culture medium comprising i) at least one monosaccharide, ii) at least one peptone of vegetable origin and / or at least one yeast extract, and optionally iii) at least one microelement. The present invention is also directed to an extract of at least one bacterium of the species Staphylococcus epidermidis, preferably an extract of at least one bacterial strain of the species Staphylococcus epidermidis selected from the group consisting of bacteria deposited at the CNCM under the serial numbers I-5688, I-5689, I-5904, I-5691, I-5692, I-5693, I-5694 and I-5695, obtainable, obtained or directly obtained by the abovementioned preparation method. The present invention is further directed to a biomass extract of at least one bacterial strain of the species Staphylococcus epidermidis selected from the group consisting of bacteria deposited at the CNCM under the serial numbers I-5688, I-5689, I-5904, I-5691, I-5692, I-5693, I-5694 and I-5695. The present invention also relates to cosmetic treatment methods and cosmetic uses of said extracts for caring for keratin materials, for preventing and / or treating signs of aging of keratin materials, and as active anti-aging agent.

A method and device for determining the aging degree of a relay protection device, the method comprising: obtaining temperatures of a plurality of relay protection devices; obtaining a plurality of ambient temperatures according to the temperatures of the plurality of relay protection devices and a mapping relationship between the ambient temperature and the temperature of each relay protection device; calculating an average value of the plurality of ambient temperatures to obtain an average ambient temperature; calibrating the temperatures of the plurality of relay protection devices according to the average ambient temperature to obtain nominal device temperatures of the plurality of relay protection devices; judging whether the absolute value of the nominal device temperature of each relay protection device is within a normal range; and determining whether each relay protection device has an aging anomaly according to the judgment result. Through the method and device provided in the embodiments of the present application, the aging degree of the relay protection device can be evaluated online only by relying on the temperature of the relay protection device, and the aging degree monitoring and early troubleshooting of the relay protection device can be realized.

The invention discloses an intelligent aging test system for an FR amplifier, which belongs to the technical field of FR amplifier testing, and comprises a constant temperature control module, a multi-parameter measurement and acquisition module, a data analysis and processing module, a system control interface module and a power supply and load management module, the multi-parameter measuring and collecting module is used for providing a constant and repeatable aging environment for a tested device, the multi-parameter measuring and collecting module is used for monitoring and recording various key performance parameters of the tested device in real time in the aging process, and the data analyzing and processing module is used for processing, analyzing and judging collected data. And the system control interface module is used for coordinating the whole test process. According to the invention, on the basis of performing aging test on the FR amplifier, life prediction can be realized, and hardware root problem analysis can be performed.