124 results about "Ageing" patented technology

In various embodiments, the disclosure provides compositions, such as polypeptides, polynucleotides, gene editing systems, small molecules, vectors, or host cells, comprising and / or modulating the expression or activity of an immunomodulatory-related protein. In various embodiments, the disclosure also provides for the treatment of aging, senescence, fibrosis, metabolic diseases, cardiovascular diseases, endocrine-related disorders, genetic diseases, cancer, infections, immune diseases, and the like using agents comprising and / or modulating the expression or activity of an immunomodulatory-related protein. Methods of replacing an adaptation of therapy or combinations thereof with hormones, growth factors and / or proteins, as well as methods of identifying the agents.

The present invention provides information comprising at least one GSK-3 activator for use in the prevention and / or treatment of aging and aging-related conditions and diseases by increasing proteasome activity.

The invention belongs to the field of daily chemicals, and provides a composition with a longevity gene activation effect, a product containing the composition and application of the composition, and the composition provided by the invention comprises hexapeptide, chlamydomonas and cornflower extract. The hexapeptide, the chlamydomonas nivalis and the cornflower extract are compounded for use, so that the expression of longevity genes KLOTHO and SIRT1 can be remarkably improved. Once the longevity gene serving as the upstream of a signal regulation pathway is activated, various downstream signal pathways can be regulated, such as inhibition of expression of inflammation-related genes, promotion of DNA repair, telomere homeostasis, gene expression of mitochondrial energy and the like, promotion of synthesis of collagen and the like, and finally, longevity of cells and improvement of skin phenotypes are promoted. The effects of resisting wrinkles, tightening and the like are achieved. Therefore, the composition provided by the invention can activate long-life gene expression and regulate and control multiple signal pathways, has potential effects of improving light aging, tightening and resisting wrinkles and the like, and is an anti-aging composition with great potential.

The invention provides a simulated aging test method for an antifouling coating. The simulated aging test method comprises the following steps: S1, constructing a natural aging performance model of the antifouling coating; s2, constructing an accelerated aging model of the antifouling coating and acquiring an acceleration ratio N of natural aging to accelerated aging; s3, based on an accelerated aging model, acquiring an acceleration period Mi corresponding to a critical threshold R (temporary i) of a copper ion exudation rate, wherein the predicted life Lp (temporary i) of the antifouling coating is equal to Mi * N; and S4, based on a natural aging model, obtaining a predicted copper ion exudation rate R < pre-i > corresponding to the predicted life Lp < pre->, judging whether R < pre-i >-R < critical i > / R < critical i > is less than or equal to 10%, if so, outputting a near threshold R < critical i > and the predicted life Lp < pre-i >, and if not, adjusting the critical threshold of the copper ion exudation rate to R < critical i + 1 > and returning to the step S3. According to the method, the performance failure threshold value of the antifouling coating is taken as a boundary condition, the performance of the antifouling coating is rapidly evaluated, the service life of the antifouling coating is quantitatively predicted, the prediction result is subjected to cooperative cross validation through linkage double models, and the reliability is improved.

Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, or any combination thereof in the central nervous system or ex vivo. Also provided herein are recombinant viruses (e.g., lentiviruses, alphaviruses, vaccinia viruses, adenoviruses, herpes viruses, retroviruses, or AAVs) comprising the engineered nucleic acids (e.g., engineered nucleic acids), engineered cells, compositions comprising the engineered nucleic acids, the recombinant viruses, engineered cells, engineered proteins, chemical agents that are capable of activating expression of OCT4; KLF4; SOX2; or any combination thereof, an engineered protein selected from the group consisting of OCT4; KLF4; SOX2; or any combination thereof, an antibody capable of activating expression of OCT4; KLF4; SOX2; or any combination thereof, and methods of treating a disease (e.g., a neurological disease), preventing a disease (e.g., neurological disease), regulating (e.g., inducing or inducing and then stopping) cellular reprogramming, regulating tissue repair, regulating tissue regeneration, or any combination thereof.

The invention relates to a P91 pipeline aging prediction method, and belongs to the field of P91 pipeline aging prediction. The method comprises the following steps: acquiring a micro-magnetic signal (such as Barkhausen noise) of a P91 pipeline through a micro-magnetic detector, and extracting characteristic parameters related to an aging state; and inputting the parameters into a pre-trained aging grade prediction model, and directly outputting the aging grade (1-5 grade) of the pipeline. The prediction model is constructed based on a machine learning algorithm (such as ReliefF feature selection and a BP neural network), and training data comes from an accelerated aging sample which is simulated through specific heat treatment and has a clear microstructure (represented by EBSD) and macromechanical property correlation. According to the method, rapid, lossless and quantitative prediction of the aging state of the P91 pipeline is realized, and a reliable basis is provided for safety assessment and residual life prediction of the in-service pipeline.

The invention relates to the technical field of rubber materials, and relates to a rubber multi-stress aging life prediction method based on an Eyring model and a PSO algorithm, and the method comprises the steps of multi-stress aging experiment data collection, single degradation track curve modeling, reference condition and acceleration factor definition, Eyring model establishment and parameter identification, and extrapolation of life under natural use conditions. According to the method, the stability of parameter estimation is remarkably improved by introducing a two-stage parameter identification method, a parameter initial value is obtained through individual curve fitting, then a shape parameter alpha and a position parameter gamma are fixed, a rate parameter beta is identified again, and the parameter standard deviation can be reduced; the ratio of the reaction rates is introduced as an acceleration factor for parameter identification instead of directly identifying the reaction rates, so that the dimensional influence and experimental system errors are effectively eliminated, data of different batches of materials under different experimental conditions have comparability, and the engineering applicability of the model is remarkably improved; the PSO algorithm is adopted to carry out global parameter optimization, so that the prediction precision and the calculation efficiency can be effectively improved.

The invention discloses Dong'e donkey-hide gelatin active peptide and application thereof. Relates to the technical field of biology. The invention provides an amino acid sequence and application of the Dong'e donkey-hide gelatin active peptide. The amino acid sequence of the CCA active peptide is YYTSASGDEMVSLK, and the CCA active peptide can significantly up-regulate the I-type collagen gene expression, increase the I-type and III-type collagen content and reduce senescence markers. The peptide fragment can be combined with TGFBR2, especially TGFBR1, gene and protein expression of the TGFBR2 can be up-regulated, downstream targets of a TGF-beta-SMAD pathway can be activated, and the MMPs / TIMPs ratio can be reduced. According to the present invention, the TGF beta-SMAD pathway is activated, the MMPs / TIMPs ratio is reduced, the collagen synthesis is promoted, and the excessive decomposition of the collagen is inhibited, such that the I type collagen content and the III type collagen content are increased, and the aging degree of the photoaging dermal fibroblast is reduced;

The invention discloses a method and a system for predicting the service life of an anti-ultraviolet aging composite insulator, and relates to the technical field of composite insulators. The method comprises the following steps: collecting product information of a to-be-evaluated anti-ultraviolet aging composite insulator, determining the corrected predicted life of the to-be-evaluated anti-ultraviolet aging composite insulator based on the product information, and predicting the service life of the to-be-evaluated anti-ultraviolet aging composite insulator based on the corrected predicted life of the to-be-evaluated anti-ultraviolet aging composite insulator. The method comprises the steps of determining an appearance state comparison value of a to-be-evaluated anti-ultraviolet aging composite insulator, determining a microscopic state comparison value of the to-be-evaluated anti-ultraviolet aging composite insulator, determining a comprehensive state value of the to-be-evaluated anti-ultraviolet aging composite insulator, and determining an actual predicted life of the to-be-evaluated anti-ultraviolet aging composite insulator based on the comprehensive state value. The problems that in the prior art, service life prediction is insufficient in accuracy, influences caused by environmental factors are not fully considered, and the service life prediction is lack of comprehensiveness are solved.

The invention discloses a plant lactobacillus with light aging resistance and an application thereof. The preservation number of the plant lactobacillus cj001 disclosed by the invention is CGMCC (China General Microbiological Culture Collection Center) No.35419. The fermentation supernatant of the plant lactobacillus cj001 shows good anti-aging activity and in-vitro antioxidant activity, and the growth ability of HaCaT cells is promoted. After the combined fermentation product of the plant lactobacillus cj001 and the lactobacillus paracasei Grx701 is subjected to ultraviolet radiation, the proliferation of HaCaT cells can be promoted, the endogenous antioxidant capacity of human skin cells can be enhanced, the photooxidation damage can be effectively relieved, and the combined fermentation product has a wide application value in the field of preparation of products with antioxidant, anti-aging, anti-ultraviolet damage, anti-photoaging and the like.

The ageing of the population is a key issue in the modern societies. The inventors have therefore searched how to determine parameters linked with the biological age of the subject. This has led them to find that characterizing mitochondria in an area of the subject enables to deduce such parameters. For this, the inventors has developed a tool providing with characterizing parameters of a mitochondrion, and notably a morphology parameter of the mitochondrion and an ultrastructure parameter of the mitochondrion. This opens the way of exploiting the characterizing parameters of mitochondria for multiples applications, such as therapy, medicine screening or clinical follow-up for aging related disorders or mitochondrial disorders.

The present invention relates to a peptide having anti-aging activity and a composition for skin regeneration or suppressing skin aging, comprising the peptide as an active ingredient. The peptide according to the present invention, comprising an amino acid sequence of SEQ ID NO: 1, has anti-aging activity and thus can be used as a raw material for a cosmetic product for skin regeneration or suppressing skin aging or as a raw material for a pharmaceutical product for preventing, ameliorating, or treating photoaging.

Compositions, methods, and kits are provided for diagnosing vitreoretinal diseases and age-related pathologies. In particular, aqueous humor biomarkers have been identified that correlate with biological aging and age-related pathologies and morbidity. The use of such biomarkers may allow earlier intervention in treatment of aging-related diseases. In addition, methods of using aqueous humor biomarkers for prognosis, diagnosis, and monitoring treatment of vitreoretinal diseases are also provided.

The invention discloses an SPD life prediction system and method based on aging detection, and relates to the technical field of aging detection. The method comprises the following steps: acquiring a current surge current signal to generate target characteristic data; taking the target feature data as the input of a pre-trained degradation prediction model to obtain the degradation weight of the current surge; calculating a residual life index value of the surge protection device according to the degradation weight and the historical degradation data; and displaying the residual life index value on a display screen. And the degradation influence of each surge on the SPD is evaluated through the pre-training model, so that the residual life of the SPD is dynamically and accurately predicted. Compared with a traditional estimation method based on the number of surges, the method can reflect the damage degree of the SPD more truly, avoids the problem of advanced replacement or delayed replacement caused by inaccurate prediction, improves the scientificity and economy of equipment operation and maintenance, supports visual display, and facilitates operation and maintenance personnel to grasp the state of the equipment in time.

Described herein are compositions and methods for performing plasmapheresis. The compositions and methods for performing plasmapheresis are innovative at least in their application towards the treatment and prevention of aging and conditions associated with aging. Plasmapheresis compositions and methods described herein are directed towards reducing or eliminating conditions associated with aging.

The invention discloses a medicinal and edible composition formula capable of resisting aging and improving sexual function. The invention belongs to the technical field of anti-aging. The medicinal and edible composition formula disclosed by the invention has remarkable anti-aging and sexual function improving effects; cell aging can be effectively delayed, the metabolic capability of a body is enhanced, and an endocrine system is regulated, so that a young state and a good sexual function are kept; according to the formula, natural medicinal and edible food materials are adopted, so that the safety is extremely high, and the side effect is extremely small; the formula is beneficial to improving the psychological state and life quality, enhancing the immunity of the body, improving the resistance of the body and reducing the occurrence of diseases.

Methods for improving quality of life and / or increasing activity in an aging and / or chronically ill mammal via administration of a composition of egg powder protein are provided.

The invention relates to a method and a device for determining and using a diagnostic tool comprising a temperature ageing spectrum, the method (P) comprising a step (E1) of receiving at least one temperature curve relating to a given geographical location, a processing step (E2) comprising a sequence of consecutive substeps (E2A, E2B, E2C, E2D, E2E), implemented iteratively for different values of a characteristic time associated with a type of material, comprising a substep (E2A) of filtering the temperature curve using a first-order filter having the characteristic time as the time constant, a substep (E2B) of applying an ageing law, a substep (E2C) of performing a cumulative calculation over a given sliding time period, a substep (E2D) of extracting a value corresponding to an ageing criterion and a substep (E2E) of associating this extracted value with the characteristic time, wherein the pairs of values obtained at the end of the iterations form a temperature ageing spectrum, and a step (E3) of performing, from at least this spectrum, comparisons in order to carry out a diagnosis.

The present invention relates to a medium composition for in vitro fertilization and / or in vitro culture comprising a compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof, and a method using same. The compound or composition suppresses reactive oxygen species and lipid peroxidation in ovarian granulosa cells to preventing cytotoxicity and mitochondrial dysfunction caused by apoptosis and ferroptosis, leading to an improvement in the quality of aged oocytes, and to increase the developmental rate and blastocyst formation rate of pre-implantation embryos, thereby improving the efficiency of in vitro fertilization. In addition, treatment with the medium composition during the vitrification process of in vitro–fertilized embryos improves re-expansion and survival rates, thereby reducing structural and metabolic damage. Accordingly, the present invention can be advantageously applied to an assisted reproductive technology for treating infertility and subfertility, and in vitro fertilization and / or in vitro culture for improving the propagation efficiency of livestock.

The invention discloses an analysis method of an XLPE thermo-oxidative aging structure evolution and insulating property correlation mechanism based on microscopic parameters. The analysis method comprises the following steps: step 1, constructing a periodic structure model of an oxygen-containing cross-linked XLPE and carrying out geometric optimization; step 2, acquiring XLPE structure models under different thermo-oxidative aging degrees by utilizing de novo molecular dynamics; 3, on the basis of a density functional theory (DFT), calculating microcosmic parameters, related to insulation performance, of XLPE of different structures under different electric field intensities by utilizing Gaussian software; and 4, depicting a'thermal oxidation aging degree-microscopic parameter 'radar map based on the change rule of the microscopic parameters of the XLPE under different thermal oxidation aging degrees, and constructing a structure-function relationship between the microscopic parameters and the different thermal oxidation aging degrees. According to the method, the thermo-oxidative aging process of the XLPE is simulated on the basis of AIMD, differences of microcosmic parameters of the XLPE under different aging degrees are compared, and the structure-function relationship between the thermo-oxidative aging degrees and the microcosmic parameters of the cross-linked XLPE is constructed more accurately.

The application belongs to the technical field of genetic engineering, and particularly relates to a citrate synthase gene AtCS The application relates to the application of a citrate synthase gene in regulating the anti-aging ability of seeds and a method for screening seed anti-aging agents. AtCS The application provides a citrate synthase gene AtCS The nucleotide sequence of the citrate synthase gene is shown as SEQ ID NO. 1. The citrate synthase gene AtCS (referred to as AtCS gene) encodes a citrate synthase located in mitochondria. AtCS The gene plays a key role in regulating the active oxygen homeostasis and anti-aging ability of seeds. AtCS The germination rate of the seed of the gene knockout mutant significantly decreases after aging, membrane lipid peroxidation products accumulate, and the active oxygen scavenging system is damaged. The mutant can be used for screening seed anti-aging agents, and provides a new solution for seed anti-aging.

The utility model discloses an aging auxiliary device for biochar. The aging auxiliary device comprises a treatment box body, a material frame, a temperature control mechanism, a humidity control mechanism and a stirring mechanism, after being opened, the top of the treatment box body is sealed by a box cover; the material frame is detachably installed in the treatment box body, and after charcoal needing to be aged is placed in the material frame, the charcoal is stirred through the stirring mechanism in the material frame; the temperature control mechanism is arranged in the treatment box body and is used for controlling the temperature around the material frame and providing the required temperature for aging; and the humidity control mechanism is arranged in the treatment box body and is used for controlling the humidity around the material frame and providing the required humidity for aging. Compared with the prior art, the aging device has the advantages that the temperature control mechanism and the humidity control mechanism are arranged, so that the temperature and the humidity in the aging environment are accurately adjusted, the aging environment under natural conditions or specific application scenes is simulated, and the aging efficiency is improved while the quality is ensured.

Integrated platforms, systems, and associated processes for measuring lifespan, body size and shape, activity, pathology, pigmentation / color, and multiple in vivo molecular biomarkers using multiple cameras are described. The integrated platform includes a plate and trays supported on the plate. Each tray can hold animals. The integrated platform also includes an imaging module with a first camera and a second camera. The first camera can capture first images associated with movement of the animals and the second camera can capture second images and third images associated with biomarkers of the animals.

Provided herein are methods that use methylation of causal CpG sites to quantify aging and predict whether an intervention will be protective or damaging to the aging process.

The invention discloses a precise positioning method for key decline nodes of aging activity of rice seeds, and belongs to the technical field of agricultural science. The method specifically comprises the following steps: (1) performing continuous different-time-length artificial accelerated aging treatment on rice seeds with the same batch and the same activity level; (2) seed soaking and germination accelerating treatment; (3) indoor normal germination test; (4) measuring seed vigor indexes; (5) statistical comparison; and (6) defining the number of aging days corresponding to the first time when statistical significant decline occurs as the aging activity key decline node of the rice seed. According to the method, by simulating natural aging conditions, the nodes (namely critical points) of key decline of the activity of the rice seeds in the artificial accelerated aging process can be accurately positioned. According to the method, the mutation inflection point of the seed activity under the high-strength aging condition is quantified for the first time, and an accurate and reliable technical standard is provided for seed aging mechanism research, activity early warning and storability evaluation.

Combination therapies comprising oxytocin and gonadotropin releasing hormone are provided. The combinations can be used to treat aging-related neurological diseases or disorders. In addition, downstream effectors of OXT-GnRH combination, including hypothalamic stem / progenitor cells-derived EVs and vesicles containing or loaded with PTMS, can be used to treat aging-related neurological diseases or disorders.

The present invention relates to a Grateloupia turuturu red algae extract and a cosmetic composition comprising thereof. The present invention also relates to a process for preparing a Grateloupia turuturu red algae extract by aqueous hot extraction. The present invention also relates to the use of said Grateloupia turuturu red algae extract as a cosmetic active ingredient, in particular as a slow-ageing agent.

The present invention relates to the field of biotechnology, and the present invention provides a composition, a culture medium, a product and a method for alleviating the aging of mature eggs. The composition comprises SB265610, MTK458 and 8-Br-cGMP. The composition can reduce the level of inflammatory factors and the toxic effect of inflammatory reactions on eggs. At the same time, it can increase the number and activity of mitochondria to provide sufficient energy guarantee for eggs. In addition, the composition can also effectively reduce the level of reactive oxygen species and the damage of oxidative stress to eggs. Through a series of combined effects, the composition significantly reduces the incidence of egg apoptosis and the rate of spindle abnormalities. By using the composition of the present invention, the aging rate of mature eggs is significantly alleviated, and the development rate is increased by nearly 20 times. The present invention provides a new strategy for animal embryo engineering and human assisted reproductive technology and has broad application prospects.

The invention discloses a neural network-driven natural ester aging degree evaluation method and system, and the method comprises the steps: S1, collecting and preprocessing near infrared spectrum data, working condition time sequence data and physicochemical index data of transformer natural ester; S2, constructing a working condition perception convolutional neural network, and extracting working condition time sequence statistical characteristics and spectrum-working condition mixed characteristics; calculating a working condition interference adaptive gating weight and a preliminary aging feature; introducing an aging characteristic consistency constraint function, calculating constrained aging characteristics, and finally extracting natural ester aging characteristics without working condition interference; s3, extracting multi-source preliminary fusion features; constructing a multi-index dynamic coupling attention mechanism, calculating a multi-index coupling feature, and then calculating an overall aging state feature of the natural ester; s4, aging classification features are calculated, and aging grade judgment is completed. The method can solve the problem of inaccurate evaluation of the aging degree of the natural ester caused by transformer load fluctuation and environment temperature change in a traditional method.

The invention relates to a method for evaluating aging and, in particular, for monitoring the condition of an electrical device (1) comprising a fixed insulation system (I) and a liquid and / or gaseous insulating medium (13) in contact with said system (I). In this method, a thermohydraulic aging model (16) is provided, and a simulation of the electrical device (1) is performed. Local temperatures (T1-T5) are calculated for different areas of the electrical device within the simulation, and the quantities of at least one aging product, which forms due to the aging of the fixed insulation system (I) and passes into the insulating medium (13), are calculated for the different areas (8a-8f). Furthermore, the invention relates to a computer program and a computer-readable storage medium.