215 results about "Ageing" patented technology

In various embodiments, the disclosure provides compositions, such as polypeptides, polynucleotides, gene editing systems, small molecules, vectors, or host cells, comprising and / or modulating the expression or activity of an immunomodulatory-related protein. In various embodiments, the disclosure also provides for the treatment of aging, senescence, fibrosis, metabolic diseases, cardiovascular diseases, endocrine-related disorders, genetic diseases, cancer, infections, immune diseases, and the like using agents comprising and / or modulating the expression or activity of an immunomodulatory-related protein. Methods of replacing an adaptation of therapy or combinations thereof with hormones, growth factors and / or proteins, as well as methods of identifying the agents.

The invention discloses an aging test method, particularly relates to the field of aging tests, and solves the problem that an aging test result is inaccurate due to the fact that a current shutdown circuit breaker aging test method excessively depends on previous data, and the aging test method specifically comprises the following steps: selecting a fixed number of shutdown circuit breaker screen model machines as test samples; constructing a first test environment and a second test environment of the test sample; performing a hygrothermal aging test on the test sample based on the test parameters of the test environment to obtain a hygrothermal aging normal signal or a hygrothermal aging abnormal signal corresponding to the test sample; performing an ultraviolet aging test on the test sample based on the test parameters of the test environment to obtain an ultraviolet aging normal signal or an ultraviolet aging abnormal signal corresponding to the test sample; the aging test result of the test sample is judged based on the test passing rate. The aging test result of the shutdown circuit breaker screen model machine is accurately analyzed.

The present invention provides information comprising at least one GSK-3 activator for use in the prevention and / or treatment of aging and aging-related conditions and diseases by increasing proteasome activity.

In various embodiments, the disclosure provides compositions, such as polypeptides, polynucleotides, gene editing systems, small molecules, vectors, or host cells, comprising and / or modulating the expression or activity of an immunomodulatory-related protein. In various embodiments, the disclosure also provides methods of treating aging, senescence, fibrosis, autoimmunity, cancer, infection, and / or immune disease using agents comprising and / or modulating the expression or activity of an immunomodulatory-related protein, as well as methods of identifying the agents.

The invention belongs to the field of daily chemicals, and provides a composition with a longevity gene activation effect, a product containing the composition and application of the composition, and the composition provided by the invention comprises hexapeptide, chlamydomonas and cornflower extract. The hexapeptide, the chlamydomonas nivalis and the cornflower extract are compounded for use, so that the expression of longevity genes KLOTHO and SIRT1 can be remarkably improved. Once the longevity gene serving as the upstream of a signal regulation pathway is activated, various downstream signal pathways can be regulated, such as inhibition of expression of inflammation-related genes, promotion of DNA repair, telomere homeostasis, gene expression of mitochondrial energy and the like, promotion of synthesis of collagen and the like, and finally, longevity of cells and improvement of skin phenotypes are promoted. The effects of resisting wrinkles, tightening and the like are achieved. Therefore, the composition provided by the invention can activate long-life gene expression and regulate and control multiple signal pathways, has potential effects of improving light aging, tightening and resisting wrinkles and the like, and is an anti-aging composition with great potential.

The disclosure provides a system for generating a multi-component aging index for an individual companion animal comprising digital biomarkers, biological biomarkers and subjective assessment methods to predict phenotypic age and phenotypic age acceleration / deceleration (phenotypic age above or below chronological age) in dogs and cats. The disclosure also provides a method for decelerating phenotypic aging of a companion animal in need thereof. The method comprises determining an index according to an aspect of the disclosure and providing personalized health, diet and nutrition measures to the companion animal according to the index for that companion animal. The method can also be considered to be a method of ameliorating accelerated aging in the animal. In some embodiments, the personalized health measure comprises a diet that decelerates phenotypic aging and / or ameliorates accelerated phenotypic aging.

Aging in an individual refers to the temporal change, mostly decline, in the body's ability to meet physiological demands. Biological age (BA) is a biomarker of chronological aging, and can be used to stratify populations to predict certain age related chronic diseases. BA can be predicted from biomedical features such as brain MRI, retina or facial images, but the inherent heterogeneity in the aging process limits the usefulness of BA predicted from individual body systems. The methods disclosed herein teach a multi-modal Transformer-based architecture with cross-attention which was able to combine facial, tongue and retina images to estimate BA. The model was trained using facial, tongue and retina images from 11, 223 healthy subjects, and demonstrated that using a fusion of the three image modalities achieved the most accurate BA predictions. The approach was validated on a test population of 2,840 individuals with six chronic diseases, and obtained significant difference between chronological age (CA) and BA (AgeDiff) than that of healthy subjects. AgeDiff has the potential to be utilized as a standalonfe biomarker, or conjunctively alongside other known factors for risk stratification and progression prediction of chronic diseases. The results therefore highlight the feasibility of using multi-modal images to estimate and interrogate the aging process.

The invention provides a simulated aging test method for an antifouling coating. The simulated aging test method comprises the following steps: S1, constructing a natural aging performance model of the antifouling coating; s2, constructing an accelerated aging model of the antifouling coating and acquiring an acceleration ratio N of natural aging to accelerated aging; s3, based on an accelerated aging model, acquiring an acceleration period Mi corresponding to a critical threshold R (temporary i) of a copper ion exudation rate, wherein the predicted life Lp (temporary i) of the antifouling coating is equal to Mi * N; and S4, based on a natural aging model, obtaining a predicted copper ion exudation rate R < pre-i > corresponding to the predicted life Lp < pre->, judging whether R < pre-i >-R < critical i > / R < critical i > is less than or equal to 10%, if so, outputting a near threshold R < critical i > and the predicted life Lp < pre-i >, and if not, adjusting the critical threshold of the copper ion exudation rate to R < critical i + 1 > and returning to the step S3. According to the method, the performance failure threshold value of the antifouling coating is taken as a boundary condition, the performance of the antifouling coating is rapidly evaluated, the service life of the antifouling coating is quantitatively predicted, the prediction result is subjected to cooperative cross validation through linkage double models, and the reliability is improved.

The present invention relates to a peptide having anti-aging activity and a composition for skin regeneration or suppressing skin aging, comprising the peptide as an active ingredient. The peptide according to the present invention, comprising an amino acid sequence of SEQ ID NO: 1, has anti-aging activity and can thus be used as a raw material for a cosmetic product for skin regeneration or suppressing skin aging, or as a raw material for a pharmaceutical product for preventing, ameliorating, or treating photoaging.

Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, or any combination thereof in the central nervous system or ex vivo. Also provided herein are recombinant viruses (e.g., lentiviruses, alphaviruses, vaccinia viruses, adenoviruses, herpes viruses, retroviruses, or AAVs) comprising the engineered nucleic acids (e.g., engineered nucleic acids), engineered cells, compositions comprising the engineered nucleic acids, the recombinant viruses, engineered cells, engineered proteins, chemical agents that are capable of activating expression of OCT4; KLF4; SOX2; or any combination thereof, an engineered protein selected from the group consisting of OCT4; KLF4; SOX2; or any combination thereof, an antibody capable of activating expression of OCT4; KLF4; SOX2; or any combination thereof, and methods of treating a disease (e.g., a neurological disease), preventing a disease (e.g., neurological disease), regulating (e.g., inducing or inducing and then stopping) cellular reprogramming, regulating tissue repair, regulating tissue regeneration, or any combination thereof.

The invention relates to a P91 pipeline aging prediction method, and belongs to the field of P91 pipeline aging prediction. The method comprises the following steps: acquiring a micro-magnetic signal (such as Barkhausen noise) of a P91 pipeline through a micro-magnetic detector, and extracting characteristic parameters related to an aging state; and inputting the parameters into a pre-trained aging grade prediction model, and directly outputting the aging grade (1-5 grade) of the pipeline. The prediction model is constructed based on a machine learning algorithm (such as ReliefF feature selection and a BP neural network), and training data comes from an accelerated aging sample which is simulated through specific heat treatment and has a clear microstructure (represented by EBSD) and macromechanical property correlation. According to the method, rapid, lossless and quantitative prediction of the aging state of the P91 pipeline is realized, and a reliable basis is provided for safety assessment and residual life prediction of the in-service pipeline.

The invention relates to the technical field of rubber materials, and relates to a rubber multi-stress aging life prediction method based on an Eyring model and a PSO algorithm, and the method comprises the steps of multi-stress aging experiment data collection, single degradation track curve modeling, reference condition and acceleration factor definition, Eyring model establishment and parameter identification, and extrapolation of life under natural use conditions. According to the method, the stability of parameter estimation is remarkably improved by introducing a two-stage parameter identification method, a parameter initial value is obtained through individual curve fitting, then a shape parameter alpha and a position parameter gamma are fixed, a rate parameter beta is identified again, and the parameter standard deviation can be reduced; the ratio of the reaction rates is introduced as an acceleration factor for parameter identification instead of directly identifying the reaction rates, so that the dimensional influence and experimental system errors are effectively eliminated, data of different batches of materials under different experimental conditions have comparability, and the engineering applicability of the model is remarkably improved; the PSO algorithm is adopted to carry out global parameter optimization, so that the prediction precision and the calculation efficiency can be effectively improved.

The invention discloses Dong'e donkey-hide gelatin active peptide and application thereof. Relates to the technical field of biology. The invention provides an amino acid sequence and application of the Dong'e donkey-hide gelatin active peptide. The amino acid sequence of the CCA active peptide is YYTSASGDEMVSLK, and the CCA active peptide can significantly up-regulate the I-type collagen gene expression, increase the I-type and III-type collagen content and reduce senescence markers. The peptide fragment can be combined with TGFBR2, especially TGFBR1, gene and protein expression of the TGFBR2 can be up-regulated, downstream targets of a TGF-beta-SMAD pathway can be activated, and the MMPs / TIMPs ratio can be reduced. According to the present invention, the TGF beta-SMAD pathway is activated, the MMPs / TIMPs ratio is reduced, the collagen synthesis is promoted, and the excessive decomposition of the collagen is inhibited, such that the I type collagen content and the III type collagen content are increased, and the aging degree of the photoaging dermal fibroblast is reduced;

The invention discloses a method and a system for predicting the service life of an anti-ultraviolet aging composite insulator, and relates to the technical field of composite insulators. The method comprises the following steps: collecting product information of a to-be-evaluated anti-ultraviolet aging composite insulator, determining the corrected predicted life of the to-be-evaluated anti-ultraviolet aging composite insulator based on the product information, and predicting the service life of the to-be-evaluated anti-ultraviolet aging composite insulator based on the corrected predicted life of the to-be-evaluated anti-ultraviolet aging composite insulator. The method comprises the steps of determining an appearance state comparison value of a to-be-evaluated anti-ultraviolet aging composite insulator, determining a microscopic state comparison value of the to-be-evaluated anti-ultraviolet aging composite insulator, determining a comprehensive state value of the to-be-evaluated anti-ultraviolet aging composite insulator, and determining an actual predicted life of the to-be-evaluated anti-ultraviolet aging composite insulator based on the comprehensive state value. The problems that in the prior art, service life prediction is insufficient in accuracy, influences caused by environmental factors are not fully considered, and the service life prediction is lack of comprehensiveness are solved.

The invention discloses a plant lactobacillus with light aging resistance and an application thereof. The preservation number of the plant lactobacillus cj001 disclosed by the invention is CGMCC (China General Microbiological Culture Collection Center) No.35419. The fermentation supernatant of the plant lactobacillus cj001 shows good anti-aging activity and in-vitro antioxidant activity, and the growth ability of HaCaT cells is promoted. After the combined fermentation product of the plant lactobacillus cj001 and the lactobacillus paracasei Grx701 is subjected to ultraviolet radiation, the proliferation of HaCaT cells can be promoted, the endogenous antioxidant capacity of human skin cells can be enhanced, the photooxidation damage can be effectively relieved, and the combined fermentation product has a wide application value in the field of preparation of products with antioxidant, anti-aging, anti-ultraviolet damage, anti-photoaging and the like.

The ageing of the population is a key issue in the modern societies. The inventors have therefore searched how to determine parameters linked with the biological age of the subject. This has led them to find that characterizing mitochondria in an area of the subject enables to deduce such parameters. For this, the inventors has developed a tool providing with characterizing parameters of a mitochondrion, and notably a morphology parameter of the mitochondrion and an ultrastructure parameter of the mitochondrion. This opens the way of exploiting the characterizing parameters of mitochondria for multiples applications, such as therapy, medicine screening or clinical follow-up for aging related disorders or mitochondrial disorders.

The present invention relates to a peptide having anti-aging activity and a composition for skin regeneration or suppressing skin aging, comprising the peptide as an active ingredient. The peptide according to the present invention, comprising an amino acid sequence of SEQ ID NO: 1, has anti-aging activity and thus can be used as a raw material for a cosmetic product for skin regeneration or suppressing skin aging or as a raw material for a pharmaceutical product for preventing, ameliorating, or treating photoaging.

Compositions, methods, and kits are provided for diagnosing vitreoretinal diseases and age-related pathologies. In particular, aqueous humor biomarkers have been identified that correlate with biological aging and age-related pathologies and morbidity. The use of such biomarkers may allow earlier intervention in treatment of aging-related diseases. In addition, methods of using aqueous humor biomarkers for prognosis, diagnosis, and monitoring treatment of vitreoretinal diseases are also provided.

The present invention relates to a peptide having anti-aging activity; and a composition for skin regeneration or suppressing skin aging, the composition comprising the peptide as an active ingredient. The peptide, comprising an amino acid sequence of SEQ ID NO: 1, according to the present invention has anti-aging activity and can thus be used as a raw material for a cosmetic product for skin regeneration or suppressing skin aging, or as material for a pharmaceutical product for preventing, ameliorating, or treating photoaging.

The present invention relates to a peptide having anti-aging activity and a composition for skin regeneration or suppressing skin aging, comprising the peptide as an active ingredient. The peptide according to the present invention, comprising an amino acid sequence of SEQ ID NO: 1, has anti-aging activity and thus can be used as a raw material for a cosmetic product for skin regeneration or suppressing skin aging or as a raw material for a pharmaceutical product for preventing, ameliorating, or treating photoaging.

The invention discloses an SPD life prediction system and method based on aging detection, and relates to the technical field of aging detection. The method comprises the following steps: acquiring a current surge current signal to generate target characteristic data; taking the target feature data as the input of a pre-trained degradation prediction model to obtain the degradation weight of the current surge; calculating a residual life index value of the surge protection device according to the degradation weight and the historical degradation data; and displaying the residual life index value on a display screen. And the degradation influence of each surge on the SPD is evaluated through the pre-training model, so that the residual life of the SPD is dynamically and accurately predicted. Compared with a traditional estimation method based on the number of surges, the method can reflect the damage degree of the SPD more truly, avoids the problem of advanced replacement or delayed replacement caused by inaccurate prediction, improves the scientificity and economy of equipment operation and maintenance, supports visual display, and facilitates operation and maintenance personnel to grasp the state of the equipment in time.

Described herein are compositions and methods for performing plasmapheresis. The compositions and methods for performing plasmapheresis are innovative at least in their application towards the treatment and prevention of aging and conditions associated with aging. Plasmapheresis compositions and methods described herein are directed towards reducing or eliminating conditions associated with aging.

The utility model discloses an anti-aging test mechanism for a pesticide packing barrel, and relates to the technical field of anti-aging tests, the anti-aging test mechanism comprises an experiment box body, the right side of the experiment box body is provided with a constant temperature device, and the experiment box body is internally provided with a double-rotation mechanism used for preventing a single pesticide packing barrel from being blown by wind for a long time to accelerate aging. The double-rotation mechanism comprises a rotation unit which is arranged in the experiment box body and comprises a rotation shaft rotatably installed in the experiment box body, the top of the experiment box body is fixedly provided with a driving motor, and the outer ring of the rotation shaft is fixedly provided with two rotation discs; the rotating unit is arranged, the driving motor operates to drive a rotating shaft to rotate, the rotating shaft rotates to drive two rotating discs to rotate, and the rotating discs drive pesticide packaging barrels mounted in the circular holes through the adaptive clamping unit to rotate, so that each pesticide packaging barrel sequentially passes through a constant-temperature air outlet hole in the right side of the inner cavity of the experiment box body; therefore, rapid aging of a single pesticide packaging barrel is avoided.

The invention discloses a medicinal and edible composition formula capable of resisting aging and improving sexual function. The invention belongs to the technical field of anti-aging. The medicinal and edible composition formula disclosed by the invention has remarkable anti-aging and sexual function improving effects; cell aging can be effectively delayed, the metabolic capability of a body is enhanced, and an endocrine system is regulated, so that a young state and a good sexual function are kept; according to the formula, natural medicinal and edible food materials are adopted, so that the safety is extremely high, and the side effect is extremely small; the formula is beneficial to improving the psychological state and life quality, enhancing the immunity of the body, improving the resistance of the body and reducing the occurrence of diseases.

Methods for improving quality of life and / or increasing activity in an aging and / or chronically ill mammal via administration of a composition of egg powder protein are provided.

The invention relates to a method and a device for determining and using a diagnostic tool comprising a temperature ageing spectrum, the method (P) comprising a step (E1) of receiving at least one temperature curve relating to a given geographical location, a processing step (E2) comprising a sequence of consecutive substeps (E2A, E2B, E2C, E2D, E2E), implemented iteratively for different values of a characteristic time associated with a type of material, comprising a substep (E2A) of filtering the temperature curve using a first-order filter having the characteristic time as the time constant, a substep (E2B) of applying an ageing law, a substep (E2C) of performing a cumulative calculation over a given sliding time period, a substep (E2D) of extracting a value corresponding to an ageing criterion and a substep (E2E) of associating this extracted value with the characteristic time, wherein the pairs of values obtained at the end of the iterations form a temperature ageing spectrum, and a step (E3) of performing, from at least this spectrum, comparisons in order to carry out a diagnosis.

The present invention relates to a medium composition for in vitro fertilization and / or in vitro culture comprising a compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof, and a method using same. The compound or composition suppresses reactive oxygen species and lipid peroxidation in ovarian granulosa cells to preventing cytotoxicity and mitochondrial dysfunction caused by apoptosis and ferroptosis, leading to an improvement in the quality of aged oocytes, and to increase the developmental rate and blastocyst formation rate of pre-implantation embryos, thereby improving the efficiency of in vitro fertilization. In addition, treatment with the medium composition during the vitrification process of in vitro–fertilized embryos improves re-expansion and survival rates, thereby reducing structural and metabolic damage. Accordingly, the present invention can be advantageously applied to an assisted reproductive technology for treating infertility and subfertility, and in vitro fertilization and / or in vitro culture for improving the propagation efficiency of livestock.

The present disclosure relates to a novel peptide for senescence treatment and a use thereof. Specifically, the peptide according to the present disclosure has a binding force with p53 superior to FOXO4 and inhibits the intracellular interaction between p53 and FOXO4, thereby enabling p53 to be released outside the nucleus and moved to mitochondria, inducing apoptosis of aged cells, and selectively inducing apoptosis of aged cells in skin cells.

The invention discloses an analysis method of an XLPE thermo-oxidative aging structure evolution and insulating property correlation mechanism based on microscopic parameters. The analysis method comprises the following steps: step 1, constructing a periodic structure model of an oxygen-containing cross-linked XLPE and carrying out geometric optimization; step 2, acquiring XLPE structure models under different thermo-oxidative aging degrees by utilizing de novo molecular dynamics; 3, on the basis of a density functional theory (DFT), calculating microcosmic parameters, related to insulation performance, of XLPE of different structures under different electric field intensities by utilizing Gaussian software; and 4, depicting a'thermal oxidation aging degree-microscopic parameter 'radar map based on the change rule of the microscopic parameters of the XLPE under different thermal oxidation aging degrees, and constructing a structure-function relationship between the microscopic parameters and the different thermal oxidation aging degrees. According to the method, the thermo-oxidative aging process of the XLPE is simulated on the basis of AIMD, differences of microcosmic parameters of the XLPE under different aging degrees are compared, and the structure-function relationship between the thermo-oxidative aging degrees and the microcosmic parameters of the cross-linked XLPE is constructed more accurately.

The application belongs to the technical field of genetic engineering, and particularly relates to a citrate synthase gene AtCS The application relates to the application of a citrate synthase gene in regulating the anti-aging ability of seeds and a method for screening seed anti-aging agents. AtCS The application provides a citrate synthase gene AtCS The nucleotide sequence of the citrate synthase gene is shown as SEQ ID NO. 1. The citrate synthase gene AtCS (referred to as AtCS gene) encodes a citrate synthase located in mitochondria. AtCS The gene plays a key role in regulating the active oxygen homeostasis and anti-aging ability of seeds. AtCS The germination rate of the seed of the gene knockout mutant significantly decreases after aging, membrane lipid peroxidation products accumulate, and the active oxygen scavenging system is damaged. The mutant can be used for screening seed anti-aging agents, and provides a new solution for seed anti-aging.