1750 results about "Nicotinamide" patented technology

The invention relates to the technical field of biomarkers, in particular to a blood biomarker combination for prediction and auxiliary diagnosis of ovarian reserve hypofunction (DOR), a corresponding detection kit and application of the blood biomarker combination. According to the invention, the content change of the nicotinamide mononucleotide (NMN) and the metabolite combination thereof in serum or plasma is screened for the first time and can be used as a detection index for predicting the ovarian reserve function decline. Based on the biomarker combination, the invention further provides an in-vitro detection kit containing a related standard substance, an internal standard solution and an extracting solution, and a data analysis method combined with a random forest model, so that an individual with a normal ovarian reserve function and an individual with hypofunction can be accurately distinguished. The method is noninvasive, simple, convenient, high in sensitivity and suitable for early recognition and layered screening of clinical ovarian reserve hypofunction.

The invention relates to a barrier repair composition for activating cell energy and application thereof, the composition comprises the following components: nicotinamide, a wheat germ extract, oat beta-glucan and a golden camellia flower extract, the four components synergistically form a full-link barrier repair system of energy supply (nicotinamide)-autophagy cleaning (wheat germ extract)-structure strengthening (beta-glucan)-oxidation defense (camellia nitidissima extract), the limitation that a traditional skin care product singly supplements lipid or resists oxidation is broken through, lipid dynamic balance is rebuilt from the root of cell metabolism, and the skin care product has the advantages that the skin care effect is good; and certain skin smoothing and anti-aging effects are achieved.

The invention relates to the technical field of cosmetics, in particular to an acne-removing composition, lipidosome and a preparation method and application thereof. The acne-removing composition disclosed by the invention is prepared from the following components in parts by weight: 2 to 8 parts of nicotinamide, 1 to 5 parts of cortex magnoliae officinalis extract, 0.15 to 2.01 parts of glycyrrhizic acid, 0.1 to 2 parts of totarol and 0.01 to 0.15 part of hyssopus officinalis extract. The nano-carrier is adopted to wrap and deliver the acne removal composition, so that the solubility of the functional components is increased, the bioavailability of the functional components is improved, meanwhile, the irritation of the functional components is also improved, multi-target co-delivery and multi-mechanism acne removal are realized, and the acne removal composition has a remarkable acne removal effect.

Composition containing Nicotinamide and vitamin B6 are provided. The composition may be an oral nutritional composition, for example a nutritional supplement, an oral nutritional supplement, a food product, a food for special medical purpose (FSMP). The composition can be administered to an individual in need thereof for treating muscle injury, and / or promoting muscle repair, improving skeletal muscle regeneration, maintaining or increasing skeletal muscle function and / or skeletal muscle mass in an individual with muscle injury.

Provided are a whitening and freckle-removing composition, a gel, a preparation method therefor, and a use thereof, relating to the technical field of skin-care products. The whitening and freckle-removing composition comprises tranexamic acid, nicotinamide, 4-butylresorcinol, licorice extract, 3-o-ethyl ascorbic acid, and glutathione. For the whitening composition, by inhibiting the activity of tyrosinase, blocking the transfer of melanin from melanocytes to keratinocytes, and inhibiting the formation and accumulation of melanin by means of multiple mechanisms including oxidation resistance, and by means of the synergistic action of all components, cosmetic benefits of whitening and freckle-removing are achieved. The whitening and freckle-removing gel has a simple preparation method, has a mild and non-sensitizing formula, is safe and non-irritating, and is suitable for large-scale production and application.

The invention belongs to the technical field of health-care food, and provides a composition containing ergothioneine and having sleep-aiding, whitening, anti-aging and anti-inflammatory effects and application thereof. The ergothioneine composition disclosed by the invention is prepared from ergothioneine, collagen peptide, carnosine, nicotinamide, an olive leaf extract and a chamomile extract. The components in the composition are matched for use, the synergistic effect is obvious, the whitening, anti-aging and anti-inflammatory effects are obviously improved, meanwhile, the composition also has a sleep-aiding effect, and the comprehensive performance is excellent.

The invention provides a whitening composition, a whitening product, a preparation method and application. The invention provides application of the milk exosome and nicotinamide in improving the autophagy ability of tranexamic acid activated melanocytes. The whitening composition provided by the invention is prepared from the following components in parts by weight: 1 to 50 parts of milk exosome, 5 to 40 parts of tranexamic acid and 0.5 to 30 parts of nicotinamide. The provided whitening composition is an active composition capable of activating the autophagy function of melanocytes of a human body, melanin synthesis in the melanocytes can be reduced by inducing generation of autophagy-related protein and activating an autophagy system, dullness of the skin is improved, the skin color is brightened through an internal channel, and the product is free of irritation and high in safety.

The invention belongs to the field of cosmetics, and discloses a composition which comprises a pepper fruit extract, epigallocatechin gallyl glucoside, diacetylboldine, a sanguisorba officinalis root extract and nicotinamide. The composition is detected by a DPPH method to have an excellent antioxidant effect. Meanwhile, the invention also discloses a composition capable of resisting thermal stimulation and UV stimulation, which can obviously inhibit the lipofuscin generation level of nematodes after thermal stimulation and UV stimulation by adopting nematode model detection. And after the composition is used together with the withanolaria nipponensis root extract, the composition has a remarkable synergistic effect on inhibition of lipofuscin generation of nematodes subjected to thermal stimulation and ultraviolet light stimulation. The composition provided by the invention has very good anti-wrinkle effects of light aging resistance and thermal aging resistance, and can effectively prevent the generation of color spots.

The invention relates to the technical field of cosmetics, and particularly discloses a composition with after-sun repairing and whitening effects and a preparation method thereof. According to the present invention, various efficient components such as the ergothioneine compound, the acetylchitosamine, the nicotinamide, the sodium hyaluronate, the inositol, the aloe vera extract, the glycerophosphoinositide choline salt, the tetrahydromethylpyrimidine carboxylic acid, the oat beta-glucan compound, the citrus peel extract compound and the skin brightening agent are scientifically matched; according to the present invention, the excellent after-sun repairing and whitening effect is achieved, the comprehensive after-sun skin care is achieved, the skin state can be improved, and the skin health degree can be improved. The application creatively finds that when the glycerophosphoinositide choline salt, the citrus peel extract compound and the skin brightening agent are compounded, the effects of the composition in the aspects of after-sun repairing and whitening can be improved at the same time, and the comprehensive effect is relatively good.

The invention provides anti-aging collagen peptide mask liquid and a preparation method thereof. The mask liquid is prepared from the following components in percentage by mass: 1 to 2 percent of tremella polysaccharide, 3 to 4 percent of herba portulacae extract, 2 to 3 percent of radix gentianae extract, 0.3 to 0.8 percent of nicotinamide, 1.2 to 1.6 percent of alpha-arbutin, 0.2 to 0.6 percent of chrysanthellum indicum extract, 0.7 to 1.5 percent of geranium flower / leaf / stem extract, 0.4 to 0.8 percent of aloe barbadensis extract, 0.7 to 1.3 percent of radix sophorae flavescentis extract, 0.3 to 0.9 percent of herba houttuyniae extract, 1.2 to 1.7 percent of herba centellae extract and the balance of water. The traditional Chinese medicine composition is prepared from the following raw materials in percentage by weight: 0.2 to 0.6 percent of fructus hippophae extract, 0.02 to 0.06 percent of peony root bark extract, 0.06 to 0.09 percent of scutellaria baicalensis root extract, 0.04 to 0.08 percent of rosemary extract, 0.01 to 0.04 percent of pearl powder and the like. The mask liquid prepared by the invention has an anti-aging effect.

A composition comprising:a) nicotinamide riboside andb) a urolithin which is a compound of formula (I) or a salt thereof:wherein:A, B, C and D are each independently selected from H and OH;W, X and Y are each independently selected from H and OH; andZ is selected from H and OH.The compositions are useful as medicaments, for example for treating muscle-related pathological conditions, neurodegenerative diseases, and / or mitochondrial diseases and as dietary supplements, functional foods and beverages, and specialised nutrition or medical foods.

Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes

The invention discloses an anti-aging face cream suitable for sensitive skin and a preparation method of the anti-aging face cream. The anti-aging face cream comprises 1-10 wt% of a supramolecular eutectic compound, 10-30 wt% of an auxiliary material and the balance of deionized water, the supramolecular eutectic compound comprises an anti-aging component, a supramolecular eutectic agent and Neosol-Aqulio, wherein the supramolecular eutectic agent is used for forming a supramolecular eutectic with the anti-aging component, and the Neosol-Aqulio is dispersed in the supramolecular eutectic; wherein the anti-aging component comprises oleuropein and hydroxytyrosol, and the supramolecular eutectic agent is nicotinamide, or a mixture of capryloyl glycine and betaine. Neosol-Aqulio, a supramolecular eutectic agent and an anti-aging component are utilized to form a supramolecular eutectic, so that active component delivery is facilitated, efficient transdermal absorption is realized, permeability, stability and mildness of the anti-aging active component are improved, the problem of sensitive skin cuticle permeation is solved, irritation of a traditional penetration enhancer is avoided, and the penetration enhancer is suitable for clinical application. The double effects of efficient permeation and mild anti-aging are realized.

The invention relates to the technical field of whitening essence, and discloses whitening essence suitable for sensitive skin and a preparation method thereof.The whitening essence suitable for sensitive skin is prepared from, by mass, 2%-3% of prinsepia utilis royle oil, 1%-2% of portulaca oleracea extract, 1.5% of camellia yunnanensis flower extract, 0.5% of panax notoginseng root extract, 3% or less of nicotinamide, 1% or less of 1, 2-propylene glycol and the balance deionized water. 1%-1.5% of 1, 2-hexanediol, 0.1%-0.3% of sodium hyaluronate and 60%-70% of deionized water. According to the whitening essence suitable for the sensitive skin and the preparation method of the whitening essence, through the synergistic combination of prinsepia utilis royle oil (barrier repair), purslane (anti-inflammatory), camellia japonica (tyrosinase inhibition) and pseudo-ginseng (microcirculation improvement), melanogenesis is inhibited through multiple channels, the sensitive skin is relieved synchronously, nicotinamide (3%) is compounded with the prinsepia utilis royle oil, and the skin whitening effect is achieved. The synergism of whitening and barrier repair is enhanced through a dual mechanism of promoting ceramide synthesis and inhibiting melanin transport, and the problems that a traditional whitening agent has different degrees of irritation, allergy phenomena such as skin redness, swelling and pain are easily caused by improper use, and a skin intolerance phenomenon exists are solved.

The invention relates to the technical field of cosmetics, in particular to moisturizing and anti-aging nanoemulsion, a preparation method thereof and moisturizing essence. The moisturizing and anti-aging nanoemulsion comprises the following raw materials in percentage by mass: 90-99% of an anti-aging component and 1-10% of a moisturizing component, and the anti-aging component comprises the following raw materials in percentage by mass: 1-20% of a glycosylglycerol solution, 0.5-3% of nicotinamide adenine dinucleotide, 0.1-5% of sodium coramate and the balance of a solvent; the moisturizing component comprises ceramide lipidosome. The raw materials in the moisturizing and anti-aging nanoemulsion synergistically exert effects, the moisturizing and anti-aging effects of the moisturizing and anti-aging nanoemulsion are improved, meanwhile, the stability and applicability of the moisturizing and anti-aging nanoemulsion are enhanced, and the moisturizing and anti-aging nanoemulsion is mild and non-irritant to skin and safe to use. The preparation method of the moisturizing anti-aging nanoemulsion is simple in process, high in production efficiency and beneficial to industrial production. The moisturizing essence has more remarkable moisturizing and anti-aging effects by adding the moisturizing and anti-aging nanoemulsion, and is safe to use.

The invention belongs to the field of nano preparations, and discloses a preparation method of nano microspheres coated with a nicotinamide mononucleotide shell membrane structure, which comprises the following steps: coating NMN in a pregel formed by chitosan and sodium tripolyphosphate, heating and stirring, adjusting the pH value to separate out chitosan-coated nano microspheres, drying to remove moisture on the surfaces of the nano microspheres, and drying to obtain the nano microspheres coated with the nicotinamide mononucleotide shell membrane structure. Then selecting a water phase and an oil phase in a proper proportion, preparing a chitosan / sodium alginate composite nano-microsphere with sodium alginate as an outer membrane by adopting an emulsion cross-linking method, and washing and drying to obtain the NMN nano-microsphere with a core-shell structure. According to the invention, NMN is coated in the nano-microsphere which is composed of two materials and has a nuclear membrane structure, so that the stability of NMN in a natural environment can be improved, hydrolysis of NMN by gastric acid and gastrointestinal tract enzyme in a drug delivery process can be prevented, the bioavailability of NMN is improved, and a drug sustained release effect is achieved.

Certain C. glutamicum strains overexpress genes coding for enzymes having the function of aspartate-semialdehyde dehydrogenase, aspartate aminotransferase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, diaminopimelate decarboxylase, aspartatokinase and diaminopimelate dehydrogenase. The C. glutamicum strains also express NAD(P)(+) transhydrogenase subunit alpha PntA and NAD(P)(+) transhydrogenase subunit beta PntB of Corynebacterium urealyticum. A method is developed for the fermentative production of L-lysine using such C. glutamicum strains.

The present invention relates to a method of increasing nicotinamide mononucleotide (NMN) and / or nicotinamide adenine dinucleotide (NAD +) in the intestinal tract of a subject, the present invention relates to a method for treating a subject by administering to the subject a combination of at least one Bifidobacterium sp. Capable of growing on a sialylated HMO and having a functional de novo nicotinamide adenine dinucleotide (nad operon (nadC, nadD, and nadE) and at least one fucosylated oligosaccharide.

The invention discloses a whitening nano-emulsion and a preparation method thereof, and relates to the technical field of cosmetics and skin care products. The whitening nano-emulsion is prepared from the following components in percentage by weight: 2.0 to 10.0 percent of an emulsifying agent, 4.0 to 10.0 percent of an emollient, 3.0 to 8.0 percent of glycerol, 3.0 to 8.0 percent of butanediol, 0.5 to 3.0 percent of nicotinamide, 1.0 to 3.0 percent of a Soulixian extract, 0.5 to 3.0 percent of ascorbyl tetraisopalmitate, 0.3 to 3.0 percent of hydrogenated lecithin, 0.1 to 2.0 percent of hydroxyethyl piperazine ethanesulfonic acid, 0.1 to 1.0 percent of SymSitive1609, 0.03 to 0.5 percent of a mulberry root extract, 0.03 to 1.0 percent of cerium oxide and the balance of water. The toothpaste is prepared from the following components in percentage by weight: 0.05 to 0.5 percent of tocopheryl acetate, 0.03 to 0.3 percent of stearyl glycyrrhetinic acid ester, 0.01 to 0.1 percent of poly gamma-sodium glutamate, 0.03 to 0.2 percent of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.2 to 1.0 percent of preservative, 0.01 to 0.1 percent of aromatic and the balance of water, wherein the total The prepared whitening nano-emulsion can solve the problems of excessive addition, difficult absorption and instability of active ingredients of cosmetics, can inhibit DPPH free radical activity, hydroxyl free radical activity and tyrosinase activity through the synergistic effect of all the components, achieves the effects of resisting oxidation, whitening, removing freckles, brightening skin and the like, and does not cause damage to the skin.

The invention discloses a glabridin-nicotinamide eutectic crystal and a preparation method and application thereof, and belongs to the technical field of eutectic crystals, the eutectic crystal comprises nicotinamide and glabridin molecules, the molecular formula of nicotinamide-glabridin is C26H26N2O5, and the molar ratio of nicotinamide to glabridin is 1: 1. According to the invention, the cocrystal is used as a raw material, complete characterization is carried out on the cocrystal to prove that the cocrystal has certain physical and chemical stability, the stability of nicotinamide is improved after the cocrystal is prepared, and no irritant substance nicotinic acid is generated in cosmetics in a cocrystal stability experiment. And the eutectic crystal is generally neutral, mild, non-irritant, natural and suitable for cosmetics or health care products.

The preparation method comprises the following preparation steps: firstly, crushing dried plumeria rubra petals, soaking the crushed plumeria rubra petals in distilled water, decocting the crushed plumeria rubra petals twice, combining filtrate, and concentrating the filtrate to obtain a plumeria rubra extracting solution; the plumeria rubra extracting solution and a rhodococcus strain are subjected to two-stage seed solution culture, then are mixed with a fermentation culture medium in a specific proportion, and are fermented under proper conditions to generate plumeria rubra fermentation liquor containing 3-cyanopyridine hydratase. Then, the fermentation liquor is subjected to biological catalysis to convert nicotinonitrile into nicotinamide, and through the steps of decoloration, filtration, concentration and the like, the plumeria rubra extract containing nicotinamide is finally obtained.

The invention provides anti-aging moisturizing essence and a preparation method thereof, and belongs to the technical field of cosmetics. The essence is prepared from a plant extract, sodium pyrrolidone carboxylate, hexapeptide, nicotinamide mononucleotide, vitamin B5, galactose yeast fermentation product filtrate, b-glucan, sodium hyaluronate, glycerol, tranexamic acid, blue copper peptide, arbutin, nicotinamide, vitrin, a bifidus yeast fermentation product, a bifidus yeast fermentation lysate and the like. Wherein the plant extract is prepared by mixing rosemary, frankincense resin, tea flowers, sandalwood and jasmine flowers through ultrasonic extraction, comprehensive skin care is achieved from multiple angles of anti-aging, whitening, moisturizing and repairing, the overall health of the skin is guaranteed, and the skin care cream is suitable for various skin types.

The invention relates to the technical field of biology, in particular to a recombinant strain for producing nicotinamide mononucleotide and application of the recombinant strain. According to the method, accumulation of the NMN is improved through metabolic flux redirection and gene knockout, a synthesis path of the NMN is successfully established in escherichia coli, and further, the yield of the NMN is effectively improved and reaches 7.0 g / L by optimizing a transport system of NAM-NMN and a PRPP synthesis path. The invention also optimizes the production process of the NMN, realizes the highest yield of the NMN of 28.5 g / L in a fed-batch fermentation system, and obviously improves the yield compared with the traditional batch fermentation.

The invention belongs to the technical field of bioengineering, and particularly relates to a polyphosphate kinase mutant and application thereof in synthesis of beta-nicotinamide mononucleotide, and the polyphosphate kinase mutant is obtained by single-point or multi-point mutation of 99th, 186th, 190th and 204th amino acids of polyphosphatase with an amino acid sequence shown as SEQ ID NO.1. The invention also relates to a preparation method of the polyphosphate kinase mutant, and the application of the polyphosphate kinase mutant in synthesis of beta-nicotinamide mononucleotide in synthesis of beta-nicotinamide mononucleotide in synthesis of beta-nicotinamide mononucleotide in synthesis of beta-nicotinamide mononucleotide. Polyphosphokinase derived from Lampropedia Hyalina DSM 16112 is subjected to molecular modification to obtain multiple mutants, the enzyme activity of the mutants is improved by 1.5-14 times compared with that of wild type polyphosphokinase, the preference of the mutants to AMP is improved by 1.08-4.88 times compared with that of the wild type polyphosphokinase, and an ATP regeneration system constructed by the mutants can remarkably reduce the use amount of enzyme and reduce the fermentation capacity and cost; the reaction time can be greatly shortened, the influence of AMP on the enzyme activity is reduced, the requirements of large-scale industrial production of NMN prepared by adopting a biological enzyme method can be met, and the method has a wide application prospect.

The invention belongs to the technical field of stem cell biological preparations, and particularly relates to an anti-aging compound preparation based on stem cells and application of the anti-aging compound preparation in delaying skin aging. The composition is composed of an inner water phase, a middle oil phase and an outer water phase, wherein the inner water phase is prepared from the following components: stem cell exosomes, hyaluronic acid, nicotinamide ribose, trehalose, mannitol, glycine and a citric acid buffer solution; the medium oil phase is prepared from the following components: medium chain triglyceride, shea butter, vitamin E succinate, PEG (Polyethylene Glycol) modified ceramide NP and cholesterol succinic acid monoester; the external water phase is prepared from the following components: polydatin, cellulose nanocrystals and an emulsifying agent. On the basis of a W / O / W emulsion system, a multi-layer anti-aging mechanism is constructed by utilizing a three-dimensional delivery framework of an inner water phase, an oil phase and an outer water phase and space-time synergy of active ingredients, the exosome permeation efficiency is improved through microneedle introduction, and the anti-oxidation and barrier repair effects are achieved by using multiple ingredients.

The invention relates to the technical field of daily chemicals, and particularly discloses a scalp oil control composition for preventing alopecia seborrhoeica as well as a preparation method and application of the scalp oil control composition. The scalp oil control composition is prepared from the following main components: nicotinamide, capryloyl glycine, piralinone ethanolamine salt, betaine salicylic acid, lemon peel extract, white willow bark extract and rice fermentation filtrate. All the components have a synergistic effect, and the effects of controlling oil, protecting hair and preventing alopecia seborrhoeica are achieved. The preparation method disclosed by the invention is simple and convenient, and the obtained product is high in bioavailability of active ingredients, good in hair care effect and low in irritation, has the effects of caring hair, strengthening hair roots, regulating scalp micro-ecology and preventing seborrheic alopecia, and can be widely applied to related washing and care products for preventing seborrheic alopecia.

The invention discloses a xanthophyll-nicotinamide eutectic crystal and a preparation method and application thereof, the eutectic crystal is formed by xanthophyll and nicotinamide according to the molar ratio of 1: 1 through intermolecular interaction of hydrogen bonds, Van der Waals force and the like, and the molecular formula is C46H62N2O3. According to the invention, xanthophyll and nicotinamide are combined through a co-crystal technology, a novel co-crystal with good water solubility and high bioavailability is formed, and the solubility and absorption efficiency of xanthophyll are significantly improved.

The invention relates to the related technical field of daily chemical skin care products, in particular to a water aqua solution for scalp care and a preparation method thereof.The water aqua solution is prepared by mixing multiple raw materials in sequence, and the multiple raw materials comprise, by concentration, 0.005% of mixed cytokines, 0.005% of auxiliary agents and the balance water. The addition amount of the vitamin B12 is 0.00006%; the addition amount of allantoin is 0.2%; the addition amount of nicotinamide is 0.7%; the adding amount of the chamomile extracting solution is 5%; the adding amount of the aloe extracting solution is 5%; the addition amount of the ginkgo biloba extract is 5%; the addition amount of the lucid ganoderma extracting solution is 5%; the addition amount of the polyol preservative is 1%; the total percentage is 100%; according to the application, the mixed cell factors, the vitamin B12, the allantoin, the nicotinamide, the chamomile extracting solution, the aloe, the gingko, the lucid ganoderma, the polyol preservative and the water are mixed, so that the scalp absorption efficiency is improved, the safety of the product can be improved, and the maintenance effect is more obvious; the problems that an existing aqueous solution for skin curing is low in component action efficiency and insufficient in adaptability and safety are solved.

The invention relates to the technical field of purification of nicotinamide ribose, in particular to a purification device and method for nicotinamide ribose, the purification device comprises a purification assembly, a filtering assembly is fixedly mounted at the lower end of the purification assembly, an adjusting assembly is fixedly mounted on the purification assembly, and the purification assembly comprises a purification barrel. A nicotinamide ribose feeding hole is fixedly formed in the purification barrel, a methanol feeding hole is fixedly formed in the upper end of the purification barrel, a motor is fixedly mounted at the upper end of the purification barrel, a stirring rod is fixedly mounted at the output end of the motor, and stirring blades are fixedly mounted on the stirring rod; the invention aims to cool and crystallize nicotinamide ribose through the purification assembly, drive the piston block I by independently pushing and pulling the piston rod I through the adjusting assembly, adjust the size of the feed opening I, change the cold air transmission rate and make the purification reaction more sufficient, and then filter nicotinamide ribose crystals through the filter assembly.

The invention relates to a nicotinamide ribose phosphate transferase mutant, a genetically engineered bacterium and application of the nicotinamide ribose phosphate transferase mutant and the genetically engineered bacterium. Compared with a wild enzyme strain NMN, the production capacity of a mutant enzyme strain is greatly improved. The saccharomyces cerevisiae genetically engineered bacterium capable of stably inheriting and efficiently synthesizing the NMN is obtained, and safe, efficient and green synthesis of the NMN is achieved.