113 results about "Type I collagen" patented technology

The invention provides a polyethylene glycol derivative-collagen cartilage repair gel which is characterized by being prepared from the following components in parts by weight: 8 to 12 parts of collagen (namely COL) solution, 0.5 to 2 parts of polydeoxyribonucleotide (namely PDRN), 4 to 8 parts of polyethylene glycol disuccinimide succinate (namely SS-PEG-SS) solution and 0.1 to 0.4 part of tannic acid (namely TA), and particularly discloses a preparation method and application of the polyethylene glycol derivative-collagen cartilage repair gel. In a word, the composite gel and the collagen are subjected to efficient amidation reaction through SS-PEG-SS to form a stable three-dimensional network, so that the structural support of the type I collagen, the tissue repair of PDRN and the anti-inflammatory and anti-oxidation characteristics of tannic acid are successfully integrated; therefore, the composite material has the comprehensive performance of good structural stability, high mechanical strength, good biocompatibility, controllable degradation period, excellent needle passing performance and the like, and shows the wide application prospects of clear repair effect, remarkable component synergistic effect, mature production process, outstanding cost effectiveness and the like.

The invention belongs to the field of daily chemicals, and discloses a PDRN-containing composition with firming and anti-wrinkle effects, and the composition comprises PDRN, saururus chinensis extract, vetiver root oil, rusty rose seed oil and ginseng seed oil. According to the composition provided by the invention, the PDRN, the saururus chinensis extract, the vetiver root oil, the rusty rose seed oil and the ginseng seed oil are compounded for use, and the components are mutually matched and synergistically promoted to obtain a synergistic effect in the aspect of promoting the secretion of type I collagen, so that the composition has remarkable tightening and anti-wrinkle effects. In addition, the composition provided by the invention also has a certain barrier repairing effect, can significantly reduce the TEWL value of skin, is mild and non-irritant, and is suitable for people with sensitive skin.

The present disclosure provides a hydrogel composition for tissue engineering and regenerative medicine, including naturally derived polymers functionalized with furan groups and nanoparticles of poly(lactic-co-glycolic acid)-poly(ethylene glycol) copolymer functionalized with maleimide groups. Covalent crosslinking via a bioorthogonal Diels-Alder click reaction forms a tunable, biocompatible, and biodegradable three-dimensional network. The hydrogel composition mimics the extracellular matrix and offers adjustable mechanical properties, controlled biodegradation, and therapeutic agent delivery for applications such as cartilage regeneration and drug delivery.

The invention relates to a composition for preventing and improving skin aging and a cosmetic containing the same. The composition comprises a red rice extract and PDRN. The composition disclosed by the invention has a synergistic effect on promoting the generation of type I collagen, so that skin aging can be remarkably prevented and / or improved.

The invention belongs to the technical field of biological medicines, and particularly relates to a method for detecting the degradation capacity of human macrophages to liver collagen in vitro. According to the scheme provided by the invention, the content of CTX I, CTX III, C3M or C1M of the liver type I collagen degradation fragment in the macrophage supernatant is detected through Elisa, the degradation capability of the macrophage on the liver collagen can be accurately reflected, and the macrophage with the liver collagen degradation capability is qualified when the CTX I of the macrophage culture supernatant is greater than 100ng / mL.

The invention discloses a fully-protected polypeptide and a preparation method thereof, belongs to the technical field of polypeptide compound synthesis, and particularly relates to fully-protected peptide resin prepared through solid-phase synthesis. Carrying out cutting and unitary cyclization on the full-protection peptide resin to obtain unitary cyclic peptide; carrying out binary cyclization treatment on the unitary cyclic peptide to obtain a bicyclic peptide compound Cyclo (His-Cys-Lys-Gly-His-Cys-Lys-Gly-, and bridging a disulfide bond with Cysamp; the binary cyclization comprises cyclization under the action of iodo methanol and ascorbic acid; or the binary cyclization is cyclized in DMSO (Dimethylsulfoxide). The anti-aging and anti-oxidation bicyclic peptide compound prepared by the preparation method disclosed by the invention has the following beneficial effects of low toxicity, good stability, capability of improving I-type collagen expression, good anti-oxidation effect and good anti-inflammatory effect.

The invention relates to an application of Quercetin (QUE) or a derivative thereof in a medicine for resisting vocal cord fibrosis and a preparation of the Quercetin or the derivative thereof. The quercetin can significantly inhibit abnormal deposition of extracellular matrix (ECM) after vocal cord injury, improve reduction of hyaluronic acid (HA) and elastic fibers (EF), and reduce overexpression of type I collagen (COL1A1) and fibronectin (FN1). Besides, by regulating PI3K / AKT and MAPK signal channels, the quercetin inhibits proliferation and migration of fibroblasts and promotes apoptosis of the fibroblasts, so that vocal cord fibrosis is effectively relieved. The invention also provides an application of a preparation of the quercetin and the derivative thereof combined or not combined with other anti-fibrosis drugs (such as 5-fluorouracil and dexamethasone) in treatment of vocal cord fibrosis, wherein the dosage forms of the preparation comprise an oral preparation, an injection, a spray or a local gel preparation.

This invention relates to a gentle whitening and anti-aging composition for sensitive skin, its preparation method, and its application, belonging to the field of cosmetic technology. The gentle whitening and anti-aging composition includes hibiscus flower extract, Tokyo cherry blossom leaf extract, redwood seed extract, and vitamin C peptides. The Tokyo cherry blossom leaf extract is obtained using a eutectic solvent (DES) combined with enzymatic extraction and resin purification. This invention constructs a multi-level synergistic whitening and anti-aging network using the above components. Efficacy testing verifies that the components in the gentle whitening composition provided by this invention can synergistically enhance the composition's ability to inhibit tyrosinase activity, scavenge DPPH free radicals, and promote type I collagen synthesis, thereby achieving skin brightening and whitening, firming and anti-wrinkle effects, improved elasticity, and reduced fine lines.

This invention provides an organ fibrosis-related micropeptide, OFMP, and its applications. This type of micropeptide, OFMP, is a translational product with endogenous biological activity and stable existence, encoded by an open reading frame (ORF) in a long non-coding RNA. It is the first time that the long non-coding RNA encoding the micropeptide has been found to be significantly related to organ fibrosis and can encode the micropeptide. Synthetic peptides prepared based on the aforementioned OFMP micropeptide show significant inhibitory effects on several key indicators of organ fibrosis, including type I collagen α1 chain gene, α-smooth muscle actin, transforming growth factor β1, and connective tissue growth factor. This indicates that the OFMP micropeptide, the nucleotide sequence (ORF) encoding the micropeptide, and the long non-coding RNA sequence containing the nucleotide sequence have important clinical diagnostic and therapeutic value for organ fibrosis.

The invention belongs to the technical field of food preparation, and particularly relates to a biological information technology guidance-based compound bovine bone collagen peptide beverage, which is prepared from the following raw materials: bovine bone collagen peptide powder, red date polysaccharide, astragalus polysaccharide, calcium carbonate, chondroitin sulfate and sodium hyaluronate. When the compound bovine bone collagen peptide beverage is drunk, bovine bone contains a large amount of collagen, is rich in type I collagen and is richer in amino acid composition, and a large number of research results show that protein is not completely hydrolyzed into amino acid after being ingested, most of the protein is absorbed in a peptide form, and the protein is absorbed in a peptide form. Therefore, the selected bovine bone collagen peptide powder can be better absorbed by the human body. The red dates have the effects of maintaining beauty, keeping young and resisting aging. In addition, astragalus membranaceus and other traditional Chinese medicine extracts are supplemented in the compound bovine bone collagen peptide beverage, so that the functional characteristics of the beverage are enhanced, and the original bad flavor of animal peptide is improved.

This invention discloses a polypeptide with anti-wrinkle and oil-controlling effects, belonging to the field of cosmetic polypeptide technology. The polypeptide is heptapeptide-6, with the amino acid sequence Asn-Asp-Glu-Gly-Leu-Tyr-Leu. At concentrations of 0.001 mg / mL to 0.1 mg / mL, heptapeptide-6 significantly promotes the synthesis of type I collagen and elastin by human skin fibroblasts, exhibiting excellent anti-wrinkle and firming activity. At concentrations of 1 ppm to 50 ppm, it significantly inhibits lipid accumulation in *C. elegans* and lipid expression in zebrafish, with a maximum lipid inhibition rate of 24.38%, and also demonstrates clear oil-controlling activity. This invention's polypeptide has a single structure, overcoming the shortcomings of existing skincare polypeptides with single efficacy and complex formulations. It features stable processing, high safety, and is suitable as a core active ingredient in anti-wrinkle and oil-controlling cosmetics, providing a new avenue for the development and application of multifunctional skincare polypeptides.

The invention discloses a fully-protected polypeptide and a preparation method thereof, belongs to the field of polypeptide synthesis and application, and particularly relates to fully-protected peptide resin prepared through solid-phase synthesis. Carrying out cutting and monocyclization on the full-protection peptide resin to obtain monocyclic peptide; the monocyclic peptide is subjected to binary cyclization treatment to obtain a cyclic peptide compound Cyclo (His-Lys-Cys-Gly-His-Lys-Cys-Gly-, and a disulfide bond is in bridge connection with Cysamp; and the binary cyclization is cyclized under the action of iodine methanol and ascorbic acid. The cyclopeptide compound prepared by the invention has the advantages of low toxicity, good stability, good antioxidant effect and good anti-inflammatory effect, and the expression of type I collagen can be improved. Therefore, the invention has the advantages of low toxicity, good stability, good antioxidant effect and good anti-inflammatory effect, and can improve the expression of the type I collagen.

This invention discloses carboxymethyl sucrose amino acid salts, their preparation, compositions, and applications. The salts are prepared from carboxymethyl sucrose and arginine, or carboxymethyl sucrose and glycine, through a chemical reaction. The resulting salts undergo a series of processes including primary alcohol precipitation, redissolution, secondary alcohol precipitation, redissolution, tertiary alcohol precipitation, soaking, pulverization, filtration, and drying to obtain carboxymethyl sucrose arginine and carboxymethyl sucrose glycine salts. A composition is prepared by mixing these two salts. Both salts and the composition significantly inhibit the activity of matrix metalloproteinase 1 and promote the expression of type I collagen, thus delaying aging by maintaining the stability of collagen morphology and structure in the extracellular matrix. The preparation method of this invention is simple and the process conditions are mild. The product has the advantages of being weakly acidic, gentle on the skin, highly safe, and having good anti-aging effects. It can be widely used in skin care cosmetics and has promising application prospects.

The application belongs to the technical field of biomedical raw materials, and particularly relates to a Yanbian yellow cattle bone-derived type I collagen as well as a preparation method and application thereof. The preparation method comprises the following steps: crushing and layering and screening fat-removed Yanbian yellow cattle bones to obtain Yanbian yellow cattle bone particles, gradiently immersing the Yanbian yellow cattle bone particles in acid to obtain mineral-removed Yanbian yellow cattle bone particles, and then removing impure proteins; using pepsin for enzymolysis to obtain an enzymolysis liquid, and then performing salting-out to obtain a crude extract; and further purifying the obtained crude extract to obtain the Yanbian yellow cattle bone-derived type I collagen. The preparation method effectively removes inorganic salts (hydroxyapatite), fat and non-collagen protein impurities in bone tissues, and the content of the finally obtained type I collagen is greater than or equal to 800 mg / g, and the product has high purity.

The application relates to a recombinant type I collagen and application thereof, which utilizes the characteristics of Pichia pastoris capable of secreting and expressing recombinant proteins, secretes the recombinant type I collagen on the culture medium supernatant, and reduces the difficulty of protein purification. In addition, the integrin site RGD is inserted into the collagen to form a recombinant type I collagen with high stability and high expression. According to the relative proliferation of cells and the relative adhesion experiment of cells, it can be seen that the recombinant type I collagen has the effects of promoting the proliferation of skin fibroblasts, improving the skin, promoting wound healing, promoting the adhesion of fibroblasts in the skin layer and the like. Therefore, the recombinant type I collagen has great potential applications in the fields of skin care and beauty, medical treatment and the like.

The invention relates to the technical field of artificial dermis, in particular to a preparation method and application of artificial dermis based on bionic acellular matrix. The artificial dermis comprises a bionic acellular matrix component A and an auxiliary material component B, wherein the component A comprises type I collagen, type VI collagen, elastin, fibronectin, laminin, mother cell protein and glucan; the component B comprises antibacterial peptide, antibiotics and a high-molecular polymer material; the mass ratio of the component A to the component B is (4-6): (1-4). The preparation method comprises the following steps: respectively preparing procedure mother liquor of the component A and the component B, preparing hydrogel with a double-layer gradient structure through step-by-step crosslinking, and then carrying out freeze drying and sterilization treatment. The artificial dermis disclosed by the invention has good biocompatibility and antibacterial property, can effectively promote wound healing, is suitable for repairing acute and chronic wounds of four limbs, faces and trunk parts, and is particularly suitable for repairing complex wounds with exposed bones, tendons, nerves and blood vessels.

Provided are a high-stability recombinant type I collagen and a use thereof, relating to the technical field of collagens. By means of the directional selection of existing amino acid sequences, potential enzyme cutting sites and unstable sequence fragments are avoided during sequence design, enabling efficient expression in Pichia pastoris; and in addition, after being purified, the recombinant type I collagen still has high stability. The recombinant type I collagen takes into account factors such as related biological active sites and hydrophilicity, has related biological activity while maintaining high stability, and has good practicability.

The invention discloses application of cyclic peptide or salt thereof in cosmetics, and belongs to the technical field of cosmetic peptides, the natural cyclic peptide comprises alanine (Ala), glycine (Gly), proline (Pro), valine (Val) and tyrosine (Tyr), and is a compound with the following formula I. The invention further discloses a preparation method of the natural cyclic peptide. The cyclopeptide compound disclosed by the invention has the effects of promoting generation of type I collagen and elastin, inhibiting generation of matrix metalloproteinase I (MMP-1) under UVA irradiation and preventing collagen degradation, so that the cyclopeptide compound has the effects of resisting wrinkles, tightening skin and the like.

The invention discloses application of gaboxadol or a pharmaceutically acceptable salt thereof in preparation of a medicine for treating liver fibrosis diseases, and belongs to the technical field of biological medicines, and research shows that the compound can influence collagen fiber crosslinking through targeted inhibition of the function of prolyl-4-hydroxylase a1 (prolyl-4-hydroxylase alpha 1, P4ha1), so that the anti-fibrosis effect is achieved. The invention further discloses an application of the gaboxadol or the pharmaceutically acceptable salt thereof in preparation of the medicine for treating the liver fibrosis diseases, and the application of the gaboxadol or the pharmaceutically acceptable salt thereof in preparation of the medicine for treating the liver fibrosis diseases and the application of the gaboxadol or the pharmaceutically acceptable salt thereof in preparation of the medicine for treating the liver fibrosis diseases. In a carbon tetrachloride induced mouse hepatic fibrosis model, the content of hydroxyproline and collagen deposition in I-type collagen molecules of the liver can be remarkably reduced by injecting the gaboxadol hydrochloride into the intraperitoneal cavity, and the hardness of the liver is reduced. A surface plasma resonance experiment proves that the probe has specific binding capacity with P4ha1. Toxicity experiments show that the compound is good in safety under the effective dosage. Therefore, the invention provides a new drug candidate and a theoretical basis for the treatment of hepatic fibrosis.

The invention belongs to the technical field of biological medicines, and discloses a deep sea steroid compound, a preparation method thereof and application of the deep sea steroid compound in preparation of medicines for preventing or treating renal fibrosis. The steroid compound is a class of highly oxidized and modified ergoketone compounds, and in some embodiments, the compound has an unusual malonyl substitution at the C-12 position of an ergoketone skeleton. The steroidal compound disclosed by the invention can achieve the effect of inhibiting renal fibrosis by regulating and controlling expression down-regulation of key fibrosis markers, namely alpha-smooth muscle actin (alpha-SMA) and I-type collagen (COL1A1), and has an inhibiting effect on proliferation of TGF-beta1-induced mouse renal fibroblasts; therefore, the compound has a great application prospect in preparation of drugs for preventing or treating renal fibrosis.

The invention relates to the technical field of cosmetics, in particular to russula vinosa extract and a preparation method and application thereof.The preparation method comprises the steps that dried russula vinosa is smashed, production water is added, heating and stirring are conducted, filtering is conducted, filtrate is reserved, production water is supplemented into filter residues, heating and stirring are continued, filtering is conducted, filtrate is reserved, production water is supplemented into the filter residues again, and the russula vinosa extract is obtained; continuously heating, stirring and extracting, filtering, and retaining filtrate; combining the three filtrates, and carrying out solid-liquid separation to obtain a clear and transparent russula vinosa extracting solution; and concentrating and drying the russula vinosa extracting solution to obtain the russula vinosa extract. The method is simple in process and high in extraction efficiency, meanwhile, the content of type I collagen, type IV collagen and elastin can be remarkably increased on the cellular level by the russula vinosa extract with the concentration of 2 mg / mL, the density of collagenous fibers and elastic fibers can be remarkably increased on human skin explant tissue, and the russula vinosa extract has good anti-wrinkle and firming effects and is suitable for being used as a skin care product. A new raw material choice is provided for preparing the anti-wrinkle and firming cosmetics.

This invention provides a biomimetic periodontal complex multilayer hydrogel tissue engineering scaffold, its preparation method, and its application, relating to the technical field of tissue engineering scaffolds. The biomimetic periodontal complex multilayer hydrogel tissue engineering scaffold comprises, from the inside out, a cementum repair layer, a periodontal ligament repair layer, and an alveolar bone repair layer; the cementum repair layer and the alveolar bone repair layer include a mineralized hydrogel layer; wherein the raw materials for preparing the mineralized hydrogel layer include modified hyaluronic acid, methacrylamide type I collagen, and hydroxyapatite; the alveolar bone repair layer includes a non-mineralized hydrogel layer; wherein the raw materials for preparing the non-mineralized hydrogel layer include modified hyaluronic acid, methacrylamide type I collagen, and fibrin I. This invention precisely matches the mechanical and biological requirements of each layer of the periodontal complex through a three-layer structure, a reversibly hydrazone-regulated viscoelastic gradient, and a differentiated biochemical microenvironment of nHAp / FBN1.

The invention discloses application of a Dow Corning SYLGARD 184 organic silicon elastomer in preparation of a three-dimensional cell culture medium, and belongs to the technical field of biological materials. The matrix is formed by mixing an A-agent prepolymer and a B-agent curing agent of SYLGARD 184 according to the weight ratio of (8-12): 1 and then curing at the temperature of 35-39 DEG C. The method is characterized in that the substrate can support cell attachment without plasma treatment, and surface modification can be carried out through I-type collagen to enhance cell adhesion, so that a unique dual-mode cell microenvironment regulation and control system is formed. The matrix provided by the invention is simple to operate, low in cost and high in batch stability, effectively overcomes the defects of uncertain components, complex hydrogel synthesis treatment and the like of the existing animal-derived matrix, and can be widely applied to three-dimensional cell culture, disease model construction and drug screening platforms.

This invention belongs to the field of cosmetic technology, specifically relating to a moisturizing and anti-wrinkle composition and its application. The moisturizing and anti-wrinkle composition provided by this invention is formulated from Cordyceps sinensis extract, Bifida ferment lysate, Stephania tetrandra extract, Butcher's broom root extract, and complex peptides in a specific ratio. Experiments show that this moisturizing and anti-wrinkle composition can promote the content of type I collagen by up to 162% and scavenge DPPH free radicals by up to 96%, demonstrating significant collagen synthesis-promoting and antioxidant capabilities, thus proving that the composition has good antioxidant and anti-aging effects. Adding this moisturizing and anti-wrinkle composition to an emulsion can significantly improve the TEWL value improvement rate, R0 improvement rate, R2 improvement rate, and wrinkle improvement rate of the emulsion. This indicates that the emulsion can significantly improve the skin barrier's moisturizing and repair capabilities, enhance skin elasticity and firmness, and effectively reduce wrinkles.

The present application relates to the technical field of artificial dermis, and particularly relates to a preparation method and application of artificial dermis based on biomimetic acellular matrix. The artificial dermis comprises a biomimetic acellular matrix component A and an auxiliary component B, wherein the component A comprises type I collagen, type VI collagen, elastin, fibronectin, laminin, matricellular protein and dextran; the component B comprises antibacterial peptide, antibiotic and high molecular polymer material; the mass ratio of the component A to the component B is (4-6):(1-4). The preparation method comprises the steps of respectively preparing A and B component process mother liquor, step-by-step crosslinking to prepare a hydrogel with a double-layer gradient structure, and then freeze-drying and sterilization treatment. The artificial dermis has good biocompatibility and antibacterial performance, can effectively promote wound healing, and is suitable for repairing acute and chronic wounds of limbs, facial parts and trunk parts, and is particularly suitable for repairing complex wounds with exposed bones, tendons, nerves and blood vessels.

The invention belongs to the technical field of cosmetics, and particularly relates to an anti-scalp aging composition and application thereof. The anti-scalp-aging composition is prepared from a rough cap fruit extract and a equisetum arvense extract, and the mass ratio of the rough cap fruit extract to the equisetum arvense extract is (1-9): (8-1). The invention researches the preparation method of the anti-scalp aging composition and the effect of the composition on scalp cells. Experimental results show that the anti-scalp aging composition can synergistically up-regulate the secretion rate of type I collagen and elastin, and has a synergistic anti-oxidation effect.

The invention relates to a collagen inducible injectable polylactic acid microsphere filler as well as a preparation method and application thereof. The preparation method of the collagen induced injectable polylactic acid microsphere filler comprises the following steps: (1) preparing polylactic acid microspheres; (2) preparing polylactic acid microspheres of which the surfaces are grafted with collagen peptide; (3) preparing a composite outer water phase; (4) preparing collagen induced polylactic acid microspheres; and (5) preparing the collagen induced injectable polylactic acid microsphere filler. According to the collagen-induced injectable polylactic acid microsphere filler, fibroblasts can be specifically activated through the collagen peptide grafted on the surfaces of the polylactic acid microspheres, I-type collagen synthesis is promoted, and the collagen regeneration effect is achieved. The agarose and the PLGA in the composite outer water phase form a composite shell on the surface of the microsphere filling agent, so that the supporting stability of the microsphere filling agent is effectively improved, the degradation of a core structure is greatly delayed, long-acting filling is realized, and the subcutaneous degradation time of rats reaches 11 months or above.

The invention provides an embryonic stem cell differentiation technology and application of the embryonic stem cell differentiation technology in screening of unknown risk alternative toxicity of a novel biological breeding product, and Cry1Ab protein is used as a test substance to evaluate the developmental toxicity of the Cry1Ab protein. The EBs are generated through hanging drop culture, and bone differentiation induction substances (beta-glycerophosphate, ascorbic acid and vitamin D3) are added to promote differentiation of the EBs. After bone cell induced differentiation is finished, the differentiation condition of bone cells is observed through alizarin red S dyeing and absorbance value detection, the cell growth condition is observed through cell total protein concentration and alkaline phosphatase activity detection, and then the influence of a test substance on the bone differentiation process is analyzed through the gene expression condition of osteogenic differentiation related markers (Runx2, SPARC and I-type collagen). The invention solves the problem of evaluating the unknown risk of a novel biological breeding product in vitro, creates an embryonic stem cell bone differentiation test technology, and uses the embryonic stem cell bone differentiation test technology as a screening method for the unknown risk alternative toxicity of the novel biological breeding product to be combined with an embryonic stem cell myocardial differentiation experiment for use. And the accuracy of predicating the developmental toxicity of the test substance is improved.

This invention belongs to the field of biological engineering technology, specifically relating to an MXene-based photothermal coupling composite film for bone repair and its preparation method; comprising MXene, type I collagen, and gelatin solution, obtained by sequential bridging and cross-linking with FeCl3 solution; wherein the mass ratio of MXene to type I collagen is (3-9):(1-7), and gelatin accounts for 3.6%-10.4% of the final composite material mass; the preparation method includes: ultrasonically dispersing MXene and mixing it with gelatin solution, then compounding it with type I collagen solution, vacuum filtering and drying to form a matrix film, and finally cross-linking it by impregnation with FeCl3 solution; this film has mechanical properties matching natural bone tissue, good biocompatibility, and high-efficiency photothermal conversion capability under near-infrared light irradiation, and is suitable for bone defect repair and photothermal synergistic therapy.

The invention belongs to the technical field of skin dressings, and particularly relates to a composite hydrogel for promoting wound healing and a preparation method thereof. The composite hydrogel for promoting wound healing comprises the following raw materials in parts by weight: 60-80 parts of a composite core, 3-8 parts of I-type collagen, 8-15 parts of gelatin and 8-15 parts of an inclusion compound, a natural biological base material is adopted as a core carrier, the stability and activity of functional components are improved through a clathrate compound technology, the outer layer accurately removes inflammation stress and provides antibacterial protection through oxidation sensitivity characteristics, the middle layer directionally recruits endogenous stem cells through active peptide to activate the repair potential, and the anti-inflammatory effect is achieved. The composite inner core guides ordered deposition of collagen through a bionic structure to achieve scar repair, and the wound healing quality is remarkably improved.